EPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)8.29621993
2nuclear pore organization (GO:0006999)7.20580325
3pore complex assembly (GO:0046931)6.13083110
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.16858387
5L-phenylalanine catabolic process (GO:0006559)5.16858387
6mitotic sister chromatid cohesion (GO:0007064)4.63742456
7L-phenylalanine metabolic process (GO:0006558)4.59724255
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.59724255
9DNA unwinding involved in DNA replication (GO:0006268)4.39659601
10fatty acid elongation (GO:0030497)4.29778572
11aromatic amino acid family catabolic process (GO:0009074)4.01861902
12sister chromatid segregation (GO:0000819)3.93907459
13dicarboxylic acid biosynthetic process (GO:0043650)3.93243649
14regulation of centriole replication (GO:0046599)3.92398029
15heterochromatin organization (GO:0070828)3.92381486
16alpha-linolenic acid metabolic process (GO:0036109)3.84975330
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.84787210
18pre-miRNA processing (GO:0031054)3.74279303
19mitotic chromosome condensation (GO:0007076)3.71867629
20cholesterol biosynthetic process (GO:0006695)3.71011794
21paraxial mesoderm development (GO:0048339)3.70605747
22bile acid biosynthetic process (GO:0006699)3.65868472
23regulation of translational fidelity (GO:0006450)3.61627834
24glutamate metabolic process (GO:0006536)3.60840785
25high-density lipoprotein particle remodeling (GO:0034375)3.50443874
26regulation of centrosome duplication (GO:0010824)3.49143095
27pyrimidine nucleobase catabolic process (GO:0006208)3.43728342
28DNA replication checkpoint (GO:0000076)3.38327657
29regulation of RNA export from nucleus (GO:0046831)3.35779436
30intestinal cholesterol absorption (GO:0030299)3.35480417
31COPII vesicle coating (GO:0048208)3.34439567
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33739840
33regulation of centrosome cycle (GO:0046605)3.33592814
34regulation of translational termination (GO:0006449)3.32942712
35DNA duplex unwinding (GO:0032508)3.31764588
36sterol biosynthetic process (GO:0016126)3.29008651
37gamma-aminobutyric acid transport (GO:0015812)3.28473889
38coenzyme catabolic process (GO:0009109)3.28438783
39long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.28389368
40cellular ketone body metabolic process (GO:0046950)3.26447108
41regulation of fibrinolysis (GO:0051917)3.24385895
42nucleobase catabolic process (GO:0046113)3.23026504
43kynurenine metabolic process (GO:0070189)3.22181077
44negative regulation of fibrinolysis (GO:0051918)3.22166370
45mitotic sister chromatid segregation (GO:0000070)3.20554719
46fatty-acyl-CoA biosynthetic process (GO:0046949)3.19864413
47neuron cell-cell adhesion (GO:0007158)3.19599775
48bile acid metabolic process (GO:0008206)3.19420504
49ribosome assembly (GO:0042255)3.19172346
50DNA geometric change (GO:0032392)3.18576543
51urea metabolic process (GO:0019627)3.17997834
52urea cycle (GO:0000050)3.17997834
53plasma lipoprotein particle remodeling (GO:0034369)3.17317069
54protein-lipid complex remodeling (GO:0034368)3.17317069
55macromolecular complex remodeling (GO:0034367)3.17317069
56positive regulation of cell cycle checkpoint (GO:1901978)3.16341583
57protein localization to chromosome, centromeric region (GO:0071459)3.15291558
58regulation of cholesterol esterification (GO:0010872)3.13895327
59Golgi transport vesicle coating (GO:0048200)3.12270982
60COPI coating of Golgi vesicle (GO:0048205)3.12270982
61DNA strand elongation involved in DNA replication (GO:0006271)3.10991596
62indole-containing compound catabolic process (GO:0042436)3.08572079
63indolalkylamine catabolic process (GO:0046218)3.08572079
64tryptophan catabolic process (GO:0006569)3.08572079
65mitotic nuclear envelope disassembly (GO:0007077)3.08530739
66cellular protein complex localization (GO:0034629)3.07877084
67protein localization to kinetochore (GO:0034501)3.07466347
68tyrosine metabolic process (GO:0006570)3.07266050
69glyoxylate metabolic process (GO:0046487)3.05554957
70protein complex localization (GO:0031503)3.04492516
71cysteine metabolic process (GO:0006534)3.04277375
72protein carboxylation (GO:0018214)3.04030223
73peptidyl-glutamic acid carboxylation (GO:0017187)3.04030223
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.03420360
75bundle of His cell to Purkinje myocyte communication (GO:0086069)3.02829971
76nuclear envelope disassembly (GO:0051081)3.01499799
77membrane disassembly (GO:0030397)3.01499799
78reverse cholesterol transport (GO:0043691)3.01374256
79long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.01210163
80cholesterol efflux (GO:0033344)3.01162085
81glutamate secretion (GO:0014047)2.99305896
82DNA strand elongation (GO:0022616)2.99096575
83regulation of protein activation cascade (GO:2000257)2.97606513
84mitotic metaphase plate congression (GO:0007080)2.92399535
85fatty-acyl-CoA metabolic process (GO:0035337)2.90831900
86tryptophan metabolic process (GO:0006568)2.90492209
87vocalization behavior (GO:0071625)2.90462404
88intestinal absorption (GO:0050892)2.90225501
89glutamine metabolic process (GO:0006541)2.89792533
90DNA replication initiation (GO:0006270)2.88538832
91very long-chain fatty acid metabolic process (GO:0000038)2.86336770
92DNA topological change (GO:0006265)2.84966259
93regulation of nucleobase-containing compound transport (GO:0032239)2.84122206
94complement activation, alternative pathway (GO:0006957)2.84113805
95ketone body metabolic process (GO:1902224)2.84076013
96aromatic amino acid family metabolic process (GO:0009072)2.83924567
97regulation of triglyceride catabolic process (GO:0010896)2.81881774
98desmosome organization (GO:0002934)2.79960112
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79872096
100establishment of integrated proviral latency (GO:0075713)2.78325960
101very-low-density lipoprotein particle assembly (GO:0034379)2.77210533
102regulation of complement activation (GO:0030449)2.76004069
103nitrogen cycle metabolic process (GO:0071941)2.75846383
104triglyceride homeostasis (GO:0070328)2.75269988
105acylglycerol homeostasis (GO:0055090)2.75269988
106regulation of sister chromatid cohesion (GO:0007063)2.75257254
107sulfur amino acid catabolic process (GO:0000098)2.72196116
108bile acid and bile salt transport (GO:0015721)2.72153281
109double-strand break repair via nonhomologous end joining (GO:0006303)2.72010769
110non-recombinational repair (GO:0000726)2.72010769
111thioester biosynthetic process (GO:0035384)2.70009272
112acyl-CoA biosynthetic process (GO:0071616)2.70009272
113embryonic foregut morphogenesis (GO:0048617)2.68978498
114presynaptic membrane assembly (GO:0097105)2.68934056
115negative regulation of keratinocyte proliferation (GO:0010839)2.68645083
116notochord development (GO:0030903)2.68638466
117negative regulation of cholesterol transport (GO:0032375)2.68201422
118negative regulation of sterol transport (GO:0032372)2.68201422
119negative regulation of protein activation cascade (GO:2000258)2.68188172
120proline biosynthetic process (GO:0006561)2.67491877
121protein export from nucleus (GO:0006611)2.67334560
122negative regulation of DNA repair (GO:0045738)2.67237529
123drug catabolic process (GO:0042737)2.66900992
124DNA conformation change (GO:0071103)2.66731146
125folic acid-containing compound biosynthetic process (GO:0009396)2.66405033
126nucleobase biosynthetic process (GO:0046112)2.65175552
127telomere maintenance via semi-conservative replication (GO:0032201)2.64518153
128alpha-amino acid catabolic process (GO:1901606)2.63281678
129positive regulation of chromosome segregation (GO:0051984)2.63166829
130neurotransmitter secretion (GO:0007269)2.62975018
131synaptic vesicle maturation (GO:0016188)2.62608891
132neuronal action potential propagation (GO:0019227)2.61943280
133dicarboxylic acid catabolic process (GO:0043649)2.61689336
134IMP biosynthetic process (GO:0006188)2.60982222
135chromosome condensation (GO:0030261)2.60483632
136serine family amino acid catabolic process (GO:0009071)2.59906179
137acetyl-CoA metabolic process (GO:0006084)2.59590608
138neurotransmitter-gated ion channel clustering (GO:0072578)2.59488174
139regulation of mitotic spindle organization (GO:0060236)2.58475156
140glycine transport (GO:0015816)2.58442456
141plasma lipoprotein particle clearance (GO:0034381)2.56622198
142positive regulation of amino acid transport (GO:0051957)2.54884020
143homocysteine metabolic process (GO:0050667)2.53910197
144NLS-bearing protein import into nucleus (GO:0006607)2.53802439
145chromatin assembly (GO:0031497)2.53721465
146hemidesmosome assembly (GO:0031581)2.51726467
147neuron recognition (GO:0008038)2.51521496
148regulation of DNA endoreduplication (GO:0032875)2.51260940
149presynaptic membrane organization (GO:0097090)2.50817858
150regulation of bile acid biosynthetic process (GO:0070857)2.50043909
151response to methylmercury (GO:0051597)2.49941211
152gap junction assembly (GO:0016264)2.49885414
153phospholipid efflux (GO:0033700)2.49237053
154chromatin remodeling at centromere (GO:0031055)2.48951387
155cellular glucuronidation (GO:0052695)2.48753963
156low-density lipoprotein particle remodeling (GO:0034374)2.47141645
157stress granule assembly (GO:0034063)2.47093638
158heme transport (GO:0015886)2.46773577
159apical protein localization (GO:0045176)2.46649000
160acyl-CoA metabolic process (GO:0006637)2.46636028
161thioester metabolic process (GO:0035383)2.46636028
162cellular amino acid catabolic process (GO:0009063)2.44955351
163plasma lipoprotein particle assembly (GO:0034377)2.44038358
164positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43266228
165axon ensheathment in central nervous system (GO:0032291)2.42821634
166central nervous system myelination (GO:0022010)2.42821634
167peroxisome fission (GO:0016559)2.42360830
168mitotic recombination (GO:0006312)2.41874290
169embryonic process involved in female pregnancy (GO:0060136)2.41506109
170DNA synthesis involved in DNA repair (GO:0000731)2.40886653
171metaphase plate congression (GO:0051310)2.40628557
172IMP metabolic process (GO:0046040)2.39385404
173regulation of chromosome segregation (GO:0051983)2.37859982
174negative regulation of mRNA metabolic process (GO:1903312)2.37617914
175telomere maintenance via recombination (GO:0000722)2.37017249
176nucleotide-sugar biosynthetic process (GO:0009226)2.35533228
177mRNA transport (GO:0051028)2.33285489
178cytoplasmic mRNA processing body assembly (GO:0033962)2.31958558
179nuclear envelope organization (GO:0006998)2.31923502
180purine nucleobase biosynthetic process (GO:0009113)2.31539982
181negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.31163631
182somatic diversification of immune receptors via somatic mutation (GO:0002566)2.30600402
183somatic hypermutation of immunoglobulin genes (GO:0016446)2.30600402
184regulation of translational elongation (GO:0006448)2.29943424
185negative regulation of mRNA processing (GO:0050686)2.28238936
186nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.27602140
187hippo signaling (GO:0035329)2.24814560
188vesicle coating (GO:0006901)2.23337843
189spliceosomal tri-snRNP complex assembly (GO:0000244)2.22584442
190UDP-N-acetylglucosamine metabolic process (GO:0006047)2.22258793
191positive regulation of dendritic spine morphogenesis (GO:0061003)2.21953239
192peptidyl-lysine dimethylation (GO:0018027)2.21742619
193protein-DNA complex disassembly (GO:0032986)2.21675867
194nucleosome disassembly (GO:0006337)2.21675867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.52431240
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.63255757
3AR_21909140_ChIP-Seq_LNCAP_Human4.16695228
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.78818098
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75265181
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.55150637
7GBX2_23144817_ChIP-Seq_PC3_Human3.52498779
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.50105782
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.69136193
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.65107956
11EZH2_22144423_ChIP-Seq_EOC_Human2.62106494
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61873949
13TAF15_26573619_Chip-Seq_HEK293_Human2.61472973
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.46825644
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.39020251
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.38873867
17PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.19683084
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10026864
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.09940562
20ESR1_15608294_ChIP-ChIP_MCF-7_Human2.03124620
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02622062
22* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01919987
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00732889
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99747078
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96404868
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96403842
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95913275
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.95077155
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94495571
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92459687
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91312463
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.88240441
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.84355416
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82174105
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82024897
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.81284917
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80483574
38AR_21572438_ChIP-Seq_LNCaP_Human1.78863219
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76911408
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74861821
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74099870
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73610539
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73295433
44ZNF263_19887448_ChIP-Seq_K562_Human1.72903720
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70064996
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69104214
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66984914
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65958755
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64598316
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64160495
51SMAD4_21799915_ChIP-Seq_A2780_Human1.63927016
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60432091
53* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59464000
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59067100
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59067100
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59052309
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58785760
58P300_19829295_ChIP-Seq_ESCs_Human1.58234978
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57695763
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.57245777
61REST_21632747_ChIP-Seq_MESCs_Mouse1.56347367
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.55282946
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53277778
64CLOCK_20551151_ChIP-Seq_293T_Human1.52962757
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.52711234
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52310350
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51042363
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50848156
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50262598
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.49008139
71FUS_26573619_Chip-Seq_HEK293_Human1.48951598
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48312678
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46283503
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45916050
75ZNF274_21170338_ChIP-Seq_K562_Hela1.45386046
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43681634
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42701055
78STAT3_23295773_ChIP-Seq_U87_Human1.41293938
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.39605732
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38639076
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.35770053
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34699973
83ELK1_19687146_ChIP-ChIP_HELA_Human1.31533397
84HTT_18923047_ChIP-ChIP_STHdh_Human1.30679453
85DROSHA_22980978_ChIP-Seq_HELA_Human1.29329155
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28532378
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28432002
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.28395390
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28301422
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27700890
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27601055
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27055965
93VDR_22108803_ChIP-Seq_LS180_Human1.27008548
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26985231
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25698685
96CHD1_26751641_Chip-Seq_LNCaP_Human1.24349202
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.23874404
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.23358431
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.22443258
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21414454
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21414454
102AHR_22903824_ChIP-Seq_MCF-7_Human1.21128806
103AR_25329375_ChIP-Seq_VCAP_Human1.20874295
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20023983
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19877836
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19690171
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18959715
108GATA6_25053715_ChIP-Seq_YYC3_Human1.18942841
109ER_23166858_ChIP-Seq_MCF-7_Human1.18816116
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.17915906
111GATA1_22025678_ChIP-Seq_K562_Human1.17915071
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17289941
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16525340
114SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15085326
115BCAT_22108803_ChIP-Seq_LS180_Human1.14974889
116TCF4_23295773_ChIP-Seq_U87_Human1.14913804
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14154519
118CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14010830
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.11277259
120TP53_18474530_ChIP-ChIP_U2OS_Human1.11254615
121SOX17_20123909_ChIP-Seq_XEN_Mouse1.10990463
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10338026
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09843113
124FOXA2_19822575_ChIP-Seq_HepG2_Human1.09456470
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09017455
126MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08795570
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07845886
128RUNX2_22187159_ChIP-Seq_PCA_Human1.06916497
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06617772
130TP53_16413492_ChIP-PET_HCT116_Human1.05098912
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04603842
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03174674
133* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02951196
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02022954
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01914414
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.01590215
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01123239
138NANOG_21062744_ChIP-ChIP_HESCs_Human1.00701350
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00504097
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00359927
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00267477
142NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99154699
143* DCP1A_22483619_ChIP-Seq_HELA_Human0.98967053
144JUN_21703547_ChIP-Seq_K562_Human0.98724812
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98702643
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98692874
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97514360
148CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96313115
149EP300_21415370_ChIP-Seq_HL-1_Mouse0.96256247
150SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96162428
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95285935
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.95127979
153FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94930939
154RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94901895
155TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94708415
156AR_19668381_ChIP-Seq_PC3_Human0.94692978
157* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94563009
158KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93448267
159FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93264821
160TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92827895
161CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92542849
162NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92117010
163STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92076216
164ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92024546
165BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91768229
166CBX2_27304074_Chip-Seq_ESCs_Mouse0.91581571
167TTF2_22483619_ChIP-Seq_HELA_Human0.90876385
168CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90326725
169TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90018977
170TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89795648
171E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89674149
172* KDM5A_27292631_Chip-Seq_BREAST_Human0.89445494
173FOXO3_23340844_ChIP-Seq_DLD1_Human0.89070435
174* XRN2_22483619_ChIP-Seq_HELA_Human0.88622464
175CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88271702
176SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86862316
177SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86862316
178TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86197490
179THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85093178
180NANOG_16153702_ChIP-ChIP_HESCs_Human0.84785588
181E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84520006
182DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84382404
183RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83608097
184HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82457903
185ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80406745
186FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78640771
187HNF4A_19822575_ChIP-Seq_HepG2_Human0.78045789
188YAP1_20516196_ChIP-Seq_MESCs_Mouse0.77097462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.99564295
2MP0005360_urolithiasis4.73004480
3MP0008057_abnormal_DNA_replication4.54744219
4MP0005085_abnormal_gallbladder_physiolo4.06721378
5MP0005365_abnormal_bile_salt3.34200583
6MP0004957_abnormal_blastocyst_morpholog3.01750644
7MP0004270_analgesia3.01358491
8MP0008875_abnormal_xenobiotic_pharmacok3.00207107
9MP0003123_paternal_imprinting2.92286654
10MP0003890_abnormal_embryonic-extraembry2.89825703
11MP0010094_abnormal_chromosome_stability2.85863946
12MP0004859_abnormal_synaptic_plasticity2.84793719
13MP0010352_gastrointestinal_tract_polyps2.82397643
14MP0003941_abnormal_skin_development2.70396520
15MP0003111_abnormal_nucleus_morphology2.68460831
16MP0003693_abnormal_embryo_hatching2.56977646
17MP0002822_catalepsy2.51944387
18MP0003880_abnormal_central_pattern2.41093802
19MP0004264_abnormal_extraembryonic_tissu2.40026584
20MP0001968_abnormal_touch/_nociception2.21825099
21MP0003252_abnormal_bile_duct2.19341193
22MP0010329_abnormal_lipoprotein_level2.14812930
23MP0003635_abnormal_synaptic_transmissio2.11928579
24MP0003806_abnormal_nucleotide_metabolis2.11338344
25MP0002735_abnormal_chemical_nociception2.08884543
26MP0003329_amyloid_beta_deposits2.08658320
27MP0003077_abnormal_cell_cycle2.07385576
28MP0009745_abnormal_behavioral_response2.01006577
29MP0002734_abnormal_mechanical_nocicepti2.00713475
30MP0002736_abnormal_nociception_after1.98121334
31MP0008932_abnormal_embryonic_tissue1.95828134
32MP0001666_abnormal_nutrient_absorption1.91398471
33MP0001730_embryonic_growth_arrest1.89137447
34MP0002009_preneoplasia1.87115401
35MP0009672_abnormal_birth_weight1.86010559
36MP0005409_darkened_coat_color1.83986076
37MP0002063_abnormal_learning/memory/cond1.80155755
38MP0005083_abnormal_biliary_tract1.78747572
39MP0002064_seizures1.78185991
40MP0008058_abnormal_DNA_repair1.70228127
41MP0002572_abnormal_emotion/affect_behav1.70112940
42MP0002272_abnormal_nervous_system1.69966958
43MP0002796_impaired_skin_barrier1.69469878
44MP0005076_abnormal_cell_differentiation1.65805906
45MP0009780_abnormal_chondrocyte_physiolo1.60688560
46MP0005380_embryogenesis_phenotype1.60115210
47MP0001672_abnormal_embryogenesis/_devel1.60115210
48MP0001486_abnormal_startle_reflex1.59171117
49MP0005332_abnormal_amino_acid1.57908355
50MP0009046_muscle_twitch1.57581337
51MP0010678_abnormal_skin_adnexa1.56188482
52MP0010307_abnormal_tumor_latency1.55050428
53MP0001697_abnormal_embryo_size1.49257574
54MP0002084_abnormal_developmental_patter1.49098657
55MP0002697_abnormal_eye_size1.48720927
56MP0003984_embryonic_growth_retardation1.48547124
57MP0000350_abnormal_cell_proliferation1.48144666
58MP0003195_calcinosis1.45575136
59MP0002733_abnormal_thermal_nociception1.45098308
60MP0002088_abnormal_embryonic_growth/wei1.44006163
61MP0003705_abnormal_hypodermis_morpholog1.43649189
62MP0001440_abnormal_grooming_behavior1.38041904
63MP0000778_abnormal_nervous_system1.38034135
64MP0003937_abnormal_limbs/digits/tail_de1.37371184
65MP0002086_abnormal_extraembryonic_tissu1.36049057
66MP0004197_abnormal_fetal_growth/weight/1.34901283
67MP0003868_abnormal_feces_composition1.33743913
68MP0002118_abnormal_lipid_homeostasis1.32409595
69MP0008007_abnormal_cellular_replicative1.30480680
70MP0000920_abnormal_myelination1.30172735
71MP0009697_abnormal_copulation1.29658648
72MP0003718_maternal_effect1.27994285
73MP0000013_abnormal_adipose_tissue1.27501269
74MP0005386_behavior/neurological_phenoty1.25545335
75MP0004924_abnormal_behavior1.25545335
76MP0002080_prenatal_lethality1.25170576
77MP0002085_abnormal_embryonic_tissue1.25031713
78MP0001529_abnormal_vocalization1.24164422
79MP0009384_cardiac_valve_regurgitation1.23212189
80MP0000604_amyloidosis1.23182596
81MP0005501_abnormal_skin_physiology1.22620360
82MP0006276_abnormal_autonomic_nervous1.22447960
83MP0001970_abnormal_pain_threshold1.21060836
84MP0002098_abnormal_vibrissa_morphology1.20833239
85MP0003690_abnormal_glial_cell1.20770148
86MP0004885_abnormal_endolymph1.18563025
87MP0002067_abnormal_sensory_capabilities1.18168081
88MP0004185_abnormal_adipocyte_glucose1.17401345
89MP0009840_abnormal_foam_cell1.16838844
90MP0005187_abnormal_penis_morphology1.15971466
91MP0009703_decreased_birth_body1.15306903
92MP0003566_abnormal_cell_adhesion1.14914129
93MP0004233_abnormal_muscle_weight1.13925457
94MP0001299_abnormal_eye_distance/1.13608032
95MP0001188_hyperpigmentation1.08808838
96MP0002184_abnormal_innervation1.08457649
97MP0000627_abnormal_mammary_gland1.08034253
98MP0000955_abnormal_spinal_cord1.07863044
99MP0002877_abnormal_melanocyte_morpholog1.07625393
100MP0005646_abnormal_pituitary_gland1.07323066
101MP0001293_anophthalmia1.06892038
102MP0001286_abnormal_eye_development1.06183774
103MP0000537_abnormal_urethra_morphology1.06094845
104MP0000428_abnormal_craniofacial_morphol1.05665427
105MP0002876_abnormal_thyroid_physiology1.04282851
106MP0004142_abnormal_muscle_tone1.03955358
107MP0000383_abnormal_hair_follicle1.02797689
108MP0003121_genomic_imprinting1.01434360
109MP0003632_abnormal_nervous_system1.01254820
110MP0001501_abnormal_sleep_pattern1.00192199
111MP0003315_abnormal_perineum_morphology0.99025184
112MP0002557_abnormal_social/conspecific_i0.97585627
113MP0002092_abnormal_eye_morphology0.97360990
114MP0001216_abnormal_epidermal_layer0.97256314
115MP0001177_atelectasis0.96439939
116MP0000377_abnormal_hair_follicle0.95564504
117MP0005423_abnormal_somatic_nervous0.95448814
118MP0000647_abnormal_sebaceous_gland0.93815550
119MP0000462_abnormal_digestive_system0.93651793
120MP0004043_abnormal_pH_regulation0.93501509
121MP0000762_abnormal_tongue_morphology0.93501118
122MP0003631_nervous_system_phenotype0.91822888
123MP0001915_intracranial_hemorrhage0.91090649
124MP0003950_abnormal_plasma_membrane0.90647680
125MP0002066_abnormal_motor_capabilities/c0.90313224
126MP0002111_abnormal_tail_morphology0.90243116
127MP0005408_hypopigmentation0.90044687
128MP0003633_abnormal_nervous_system0.89494383
129MP0004782_abnormal_surfactant_physiolog0.89441110
130MP0010234_abnormal_vibrissa_follicle0.89144427
131MP0004811_abnormal_neuron_physiology0.88141379
132MP0003861_abnormal_nervous_system0.87737297
133MP0001849_ear_inflammation0.87038476
134MP0000467_abnormal_esophagus_morphology0.86714810
135MP0002229_neurodegeneration0.86296026
136MP0001661_extended_life_span0.85092426
137MP0003634_abnormal_glial_cell0.84955563
138MP0004019_abnormal_vitamin_homeostasis0.84804320
139MP0000609_abnormal_liver_physiology0.84276371
140MP0005451_abnormal_body_composition0.83519662
141MP0002090_abnormal_vision0.83427843
142MP0002882_abnormal_neuron_morphology0.82104265
143MP0003943_abnormal_hepatobiliary_system0.81953243
144MP0002233_abnormal_nose_morphology0.81106063
145MP0000579_abnormal_nail_morphology0.80880919
146MP0009053_abnormal_anal_canal0.80151852
147MP0003786_premature_aging0.79027196
148MP0002396_abnormal_hematopoietic_system0.78775965
149MP0003567_abnormal_fetal_cardiomyocyte0.78343988
150MP0005171_absent_coat_pigmentation0.77265512
151MP0003935_abnormal_craniofacial_develop0.75705332
152MP0000432_abnormal_head_morphology0.73591612
153MP0004742_abnormal_vestibular_system0.73491530
154MP0005448_abnormal_energy_balance0.71918934
155MP0001485_abnormal_pinna_reflex0.71679083
156MP0004272_abnormal_basement_membrane0.71594998
157MP0002069_abnormal_eating/drinking_beha0.70278812
158MP0002909_abnormal_adrenal_gland0.69870827
159MP0003453_abnormal_keratinocyte_physiol0.69653271
160MP0005621_abnormal_cell_physiology0.69365784
161MP0002078_abnormal_glucose_homeostasis0.68489077
162MP0005384_cellular_phenotype0.66869481
163MP0001963_abnormal_hearing_physiology0.66187741
164MP0003115_abnormal_respiratory_system0.66068454
165MP0000427_abnormal_hair_cycle0.66051501
166MP0002081_perinatal_lethality0.64884330
167MP0005584_abnormal_enzyme/coenzyme_acti0.63826696
168MP0002152_abnormal_brain_morphology0.63594130
169MP0001905_abnormal_dopamine_level0.63434860
170MP0008569_lethality_at_weaning0.63301607
171MP0000313_abnormal_cell_death0.62042275
172MP0003385_abnormal_body_wall0.61549865
173MP0000566_synostosis0.60808491
174MP0004858_abnormal_nervous_system0.60433183
175MP0005551_abnormal_eye_electrophysiolog0.59492698
176MP0001664_abnormal_digestion0.59492382
177MP0002837_dystrophic_cardiac_calcinosis0.58819544
178MP0008874_decreased_physiological_sensi0.57706474
179MP0003122_maternal_imprinting0.57620598
180MP0005535_abnormal_body_temperature0.56819287
181MP0005084_abnormal_gallbladder_morpholo0.56584456

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.11564705
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.72957553
3Hypobetalipoproteinemia (HP:0003563)4.59777569
4Chromsome breakage (HP:0040012)4.55941835
5Deep venous thrombosis (HP:0002625)4.48418987
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.26001903
7Xanthomatosis (HP:0000991)4.15849938
8Prolonged partial thromboplastin time (HP:0003645)3.78626448
9Insidious onset (HP:0003587)3.74031760
10Termporal pattern (HP:0011008)3.74031760
11Conjugated hyperbilirubinemia (HP:0002908)3.72841336
12Epidermoid cyst (HP:0200040)3.66592589
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.63332519
14Focal motor seizures (HP:0011153)3.48042193
15Hypolipoproteinemia (HP:0010981)3.19349924
16Hyperlipoproteinemia (HP:0010980)3.16615386
17Abnormality of the corticospinal tract (HP:0002492)3.12971526
18Myokymia (HP:0002411)3.08138106
19Fat malabsorption (HP:0002630)2.99923854
20Degeneration of the lateral corticospinal tracts (HP:0002314)2.94253399
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.94253399
22Papillary thyroid carcinoma (HP:0002895)2.93550063
23Abnormality of methionine metabolism (HP:0010901)2.91913623
24Neurofibrillary tangles (HP:0002185)2.87141718
25Asymmetry of the thorax (HP:0001555)2.86153419
26Atonic seizures (HP:0010819)2.84847999
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.78905092
28Abnormality of sulfur amino acid metabolism (HP:0004339)2.76331275
29Acanthocytosis (HP:0001927)2.76148691
30Cerebral inclusion bodies (HP:0100314)2.74651932
31Nephroblastoma (Wilms tumor) (HP:0002667)2.72680719
32Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72209202
33Focal seizures (HP:0007359)2.70767733
34Hyperventilation (HP:0002883)2.69083790
35Ankyloglossia (HP:0010296)2.67589622
36Hyperglycinemia (HP:0002154)2.64418233
37Cortical dysplasia (HP:0002539)2.63935792
38Embryonal renal neoplasm (HP:0011794)2.60523030
39Hypophosphatemic rickets (HP:0004912)2.59504050
40Right ventricular cardiomyopathy (HP:0011663)2.54762760
41Increased nuchal translucency (HP:0010880)2.50389968
42Epileptic encephalopathy (HP:0200134)2.47264967
43Abnormality of chromosome stability (HP:0003220)2.46947754
44Complement deficiency (HP:0004431)2.46921439
45Abnormality of the common coagulation pathway (HP:0010990)2.44157193
46Missing ribs (HP:0000921)2.43126269
47Selective tooth agenesis (HP:0001592)2.42691349
48Hypoalphalipoproteinemia (HP:0003233)2.39266989
49Action tremor (HP:0002345)2.37606348
50Scanning speech (HP:0002168)2.37120541
51Abnormality of the preputium (HP:0100587)2.36774533
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33203671
53Skin nodule (HP:0200036)2.33137560
54Overlapping toe (HP:0001845)2.32077294
55Abnormal foot bone ossification (HP:0010675)2.28997491
56Meckel diverticulum (HP:0002245)2.27571597
57Hepatoblastoma (HP:0002884)2.27232545
58Ketosis (HP:0001946)2.21892660
59Curly hair (HP:0002212)2.21478766
60Deviation of the thumb (HP:0009603)2.20313168
61Sensory axonal neuropathy (HP:0003390)2.19730790
62Abnormality of glycolysis (HP:0004366)2.18721873
63Increased serum pyruvate (HP:0003542)2.18721873
64Abnormality of the intrinsic pathway (HP:0010989)2.17396944
65Abnormality of serine family amino acid metabolism (HP:0010894)2.17304295
66Abnormality of glycine metabolism (HP:0010895)2.17304295
67Gastrointestinal carcinoma (HP:0002672)2.16958095
68Malignant gastrointestinal tract tumors (HP:0006749)2.16958095
69Pheochromocytoma (HP:0002666)2.16414077
70Progressive external ophthalmoplegia (HP:0000590)2.16132671
71Blue irides (HP:0000635)2.14761752
72Cholecystitis (HP:0001082)2.14336783
73Abnormal gallbladder physiology (HP:0012438)2.14336783
74Spastic gait (HP:0002064)2.12848225
75Abnormality of the ileum (HP:0001549)2.12522398
76Flat acetabular roof (HP:0003180)2.12470835
77Deep philtrum (HP:0002002)2.12003903
78Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.09566941
79Absence seizures (HP:0002121)2.07930618
80Impaired vibration sensation in the lower limbs (HP:0002166)2.07518456
81Megaloblastic anemia (HP:0001889)2.06939522
82Birth length less than 3rd percentile (HP:0003561)2.06807872
83Thyroid carcinoma (HP:0002890)2.05236475
84Dialeptic seizures (HP:0011146)2.04956744
85Hyperammonemia (HP:0001987)2.02796121
86Septate vagina (HP:0001153)2.02739344
87Excessive salivation (HP:0003781)2.02668269
88Drooling (HP:0002307)2.02668269
89Heterotopia (HP:0002282)2.02329150
90Rhabdomyosarcoma (HP:0002859)2.01621032
91Proximal placement of thumb (HP:0009623)2.01571372
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.01270062
93Leiomyosarcoma (HP:0100243)2.01099734
94Uterine leiomyosarcoma (HP:0002891)2.01099734
95Pili torti (HP:0003777)1.99818418
96Papilledema (HP:0001085)1.99098352
97Parakeratosis (HP:0001036)1.97884868
98Dysmetria (HP:0001310)1.96816002
99Abnormal tarsal ossification (HP:0008369)1.95529790
100Abnormal gallbladder morphology (HP:0012437)1.95193929
101Abnormality of vitamin metabolism (HP:0100508)1.94763553
102Ankle clonus (HP:0011448)1.94104556
10311 pairs of ribs (HP:0000878)1.93778893
104Epileptiform EEG discharges (HP:0011182)1.93098660
105Medulloblastoma (HP:0002885)1.92828858
106Hypoglycemic seizures (HP:0002173)1.92550518
107Generalized tonic-clonic seizures (HP:0002069)1.92298575
108Absent eyebrow (HP:0002223)1.92218200
109Morphological abnormality of the pyramidal tract (HP:0002062)1.92114320
110Hypoglycemic coma (HP:0001325)1.92027475
111Pancreatic islet-cell hyperplasia (HP:0004510)1.91934503
112Hyperbilirubinemia (HP:0002904)1.91538564
113EEG with generalized epileptiform discharges (HP:0011198)1.90701422
114Hypsarrhythmia (HP:0002521)1.89494215
115Urinary urgency (HP:0000012)1.89123166
116Supranuclear gaze palsy (HP:0000605)1.88945379
117Hammertoe (HP:0001765)1.88601632
118Abnormality of oral frenula (HP:0000190)1.88107299
119Abnormal social behavior (HP:0012433)1.87942837
120Impaired social interactions (HP:0000735)1.87942837
121Urinary bladder sphincter dysfunction (HP:0002839)1.87475257
122Hyperglycemia (HP:0003074)1.87220401
123Clonus (HP:0002169)1.86566754
124Volvulus (HP:0002580)1.86556411
125Sandal gap (HP:0001852)1.86521970
126Microvesicular hepatic steatosis (HP:0001414)1.84736813
127Glioma (HP:0009733)1.84501867
128Absent eyelashes (HP:0000561)1.84470885
129Breast carcinoma (HP:0003002)1.84121936
130Dysdiadochokinesis (HP:0002075)1.83899668
131Spastic tetraplegia (HP:0002510)1.83116036
132Torticollis (HP:0000473)1.82160309
133Truncal ataxia (HP:0002078)1.81688816
134Spastic paraparesis (HP:0002313)1.80894840
135Febrile seizures (HP:0002373)1.80461896
136Subacute progressive viral hepatitis (HP:0006572)1.79903368
137Aplasia involving bones of the extremities (HP:0009825)1.79373792
138Aplasia involving bones of the upper limbs (HP:0009823)1.79373792
139Aplasia of the phalanges of the hand (HP:0009802)1.79373792
140Dysmetric saccades (HP:0000641)1.79162544
141Enlarged kidneys (HP:0000105)1.79136605
142Embryonal neoplasm (HP:0002898)1.78834529
143Akinesia (HP:0002304)1.78760122
144Anal stenosis (HP:0002025)1.78653120
145Back pain (HP:0003418)1.78107918
146Status epilepticus (HP:0002133)1.78084022
147Confusion (HP:0001289)1.77731504
148Small epiphyses (HP:0010585)1.77555806
149Ulnar claw (HP:0001178)1.77101675
150Hyperinsulinemic hypoglycemia (HP:0000825)1.76495809
151Relative macrocephaly (HP:0004482)1.76073273
152Steatorrhea (HP:0002570)1.76039667
153Advanced eruption of teeth (HP:0006288)1.75990296
154Transitional cell carcinoma of the bladder (HP:0006740)1.75346249
155Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75196152
156Absent radius (HP:0003974)1.73933547
157Abnormality of the gastric mucosa (HP:0004295)1.73928671
158Intention tremor (HP:0002080)1.73757345
159Paraplegia (HP:0010550)1.73624539
160Abnormality of the salivary glands (HP:0010286)1.73402643
161Biliary tract neoplasm (HP:0100574)1.73204845
162Abnormality of the astrocytes (HP:0100707)1.71793096
163Astrocytoma (HP:0009592)1.71793096
164Fair hair (HP:0002286)1.71702208
165Broad alveolar ridges (HP:0000187)1.71540386
166Generalized myoclonic seizures (HP:0002123)1.70629304
167Uterine neoplasm (HP:0010784)1.70544650
168Abnormality of nail color (HP:0100643)1.69723372
169Abnormality of the carotid arteries (HP:0005344)1.69053247
170Microglossia (HP:0000171)1.68903420
171Short chin (HP:0000331)1.68159178
172Cafe-au-lait spot (HP:0000957)1.67401374
173Ependymoma (HP:0002888)1.67164277
174Diastasis recti (HP:0001540)1.65840388
175High anterior hairline (HP:0009890)1.65826682
176Abnormal lung lobation (HP:0002101)1.65787101
177Multiple enchondromatosis (HP:0005701)1.65468858
178Abnormal cartilage morphology (HP:0002763)1.61596665
179Choanal atresia (HP:0000453)1.61137658
180Skull defect (HP:0001362)1.60660043
181Capillary hemangiomas (HP:0005306)1.60547689
182Bladder neoplasm (HP:0009725)1.60014981
183Bladder carcinoma (HP:0002862)1.60014981
184Gastroesophageal reflux (HP:0002020)1.58437941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.69513531
2TSSK63.14794956
3CDC73.10700574
4EPHA43.01852731
5MARK12.88317603
6NTRK32.68999604
7STK392.63986205
8TTK2.61078410
9CDK122.58876566
10INSRR2.39989418
11PBK2.38908814
12SCYL22.37750501
13ERBB42.36411404
14NEK12.34222565
15EIF2AK12.26892342
16MAP3K42.21952035
17NTRK12.10198488
18SRPK12.08578938
19EEF2K2.05023708
20FRK2.04474986
21EIF2AK32.02017386
22MAP3K21.96423049
23OXSR11.85606453
24BRSK21.83713643
25MAP2K41.82492079
26MAP3K101.82445967
27CAMK1D1.81600958
28TAF11.75664927
29MAP3K91.75468757
30BRD41.72834654
31LATS21.72543216
32MAP2K71.71748153
33LATS11.68865878
34WEE11.66325821
35DAPK21.66294667
36PLK41.65050232
37CAMK1G1.64948529
38AKT31.64535166
39MINK11.63265865
40BCR1.61589907
41ZAK1.59682494
42FGFR21.59120964
43PNCK1.57683744
44TNIK1.56668604
45NUAK11.49191978
46MET1.47229544
47PLK21.45893223
48KSR21.45562419
49MAPK131.41000835
50PAK31.40604032
51ICK1.40413533
52PAK61.38926453
53MKNK11.35543473
54MST1R1.35338436
55IRAK21.33972370
56PLK31.32197894
57SMG11.31224708
58MKNK21.29253655
59STK31.28730372
60RPS6KB21.24313694
61FER1.23293285
62MST41.21440125
63WNK41.21000691
64LIMK11.19918849
65NTRK21.19214326
66UHMK11.18767228
67SGK2231.17775623
68SGK4941.17775623
69CAMK2B1.17139088
70CDK51.12394875
71BUB11.12089029
72KSR11.10522346
73FGFR41.10029976
74RET1.09898725
75CAMKK21.07521033
76CAMK2A1.04727118
77CHEK21.00779687
78CAMKK11.00606394
79EPHB10.98469296
80ALK0.97491280
81BRSK10.97072055
82TYRO30.94096965
83ERBB30.92679274
84CSNK1G20.91145343
85PRKCG0.90940913
86CDK70.89199156
87EIF2AK20.85082785
88CAMK2D0.84034339
89PRKCE0.83586241
90PLK10.83369909
91STK38L0.82806130
92PIK3CG0.81263866
93CHEK10.80678655
94ATR0.80508819
95PKN10.79967898
96MAP2K10.78490798
97SGK20.77607648
98ATM0.77249541
99PIK3CA0.76175797
100DDR20.74167645
101MAP3K120.73777298
102ACVR1B0.73469559
103NEK20.73293897
104CDK60.72261997
105CDK140.71427169
106CAMK2G0.71321283
107IRAK10.68923343
108WNK10.67951811
109AURKB0.67014100
110SGK10.64425022
111CDK180.64166243
112PRPF4B0.64109044
113GRK50.63783335
114FGFR30.63736879
115MAPKAPK50.63620812
116BRAF0.63588637
117CDK150.62809440
118EPHA30.62471352
119CSNK1G30.61439037
120PTK20.60953540
121CDK10.60951006
122DYRK20.59945800
123YES10.59634938
124STK240.58963428
125MTOR0.58502890
126FGR0.57722032
127CSNK1G10.56869593
128NEK60.56711387
129SGK30.53840665
130STK110.53608628
131CDK20.53581976
132PDPK10.52872218
133PRKCZ0.51521067
134PKN20.51271802
135PRKD30.50799725
136CSNK1A1L0.50293946
137WNK30.50035357
138RPS6KB10.49674600
139CSNK1E0.49085783
140ROCK20.48305190
141CDK11A0.48144251
142FGFR10.47338571
143LMTK20.47184392
144RPS6KA40.46072052
145ERBB20.44293943
146PAK40.42961576
147RPS6KA30.42419641
148AKT20.41867647
149FYN0.40681793
150PRKDC0.40385264
151PRKCB0.40319002
152TAOK30.39639047
153PRKG10.39222345
154CDK190.38519467
155EPHA20.37722939
156CSNK1A10.37463264
157MELK0.37381456
158RIPK10.36834020
159BCKDK0.35772207
160CSNK1D0.35691299
161PDGFRA0.35637443
162CDK40.34460177
163IRAK30.32582331
164GSK3B0.32006515
165MAPK100.31588855
166MAPK140.31539533
167SIK10.31406811
168MAP3K80.31014275
169CLK10.30925962

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.24915775
2Nitrogen metabolism_Homo sapiens_hsa009103.09626185
3Steroid biosynthesis_Homo sapiens_hsa001002.71626150
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57809007
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57131401
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53830509
7Butanoate metabolism_Homo sapiens_hsa006502.49388383
8Arginine biosynthesis_Homo sapiens_hsa002202.42641755
9DNA replication_Homo sapiens_hsa030302.41376178
10Mismatch repair_Homo sapiens_hsa034302.23962792
11Non-homologous end-joining_Homo sapiens_hsa034502.18559974
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17047072
13Sulfur metabolism_Homo sapiens_hsa009202.15381408
14Cell cycle_Homo sapiens_hsa041102.14032066
15Fatty acid elongation_Homo sapiens_hsa000622.02323453
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96664737
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91314164
18RNA transport_Homo sapiens_hsa030131.90185637
19One carbon pool by folate_Homo sapiens_hsa006701.88621726
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88137270
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.85511381
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81214215
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80223820
24Tryptophan metabolism_Homo sapiens_hsa003801.79768716
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73921576
26mRNA surveillance pathway_Homo sapiens_hsa030151.72965874
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68562756
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60887007
29Bile secretion_Homo sapiens_hsa049761.58627514
30Fatty acid metabolism_Homo sapiens_hsa012121.58270691
31Thyroid cancer_Homo sapiens_hsa052161.54637995
32Histidine metabolism_Homo sapiens_hsa003401.54233171
33Nicotine addiction_Homo sapiens_hsa050331.52358436
34Fat digestion and absorption_Homo sapiens_hsa049751.50177188
35Fatty acid degradation_Homo sapiens_hsa000711.49171465
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46362784
37Complement and coagulation cascades_Homo sapiens_hsa046101.45709950
38Vitamin B6 metabolism_Homo sapiens_hsa007501.41518830
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40914686
40Nucleotide excision repair_Homo sapiens_hsa034201.37883854
41Propanoate metabolism_Homo sapiens_hsa006401.37792579
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32788779
43PPAR signaling pathway_Homo sapiens_hsa033201.30207715
44Spliceosome_Homo sapiens_hsa030401.29515672
45Peroxisome_Homo sapiens_hsa041461.28328026
46GABAergic synapse_Homo sapiens_hsa047271.24815859
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.19156496
48Adherens junction_Homo sapiens_hsa045201.15684172
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.15085732
50beta-Alanine metabolism_Homo sapiens_hsa004101.14378067
51Glutamatergic synapse_Homo sapiens_hsa047241.13972195
52Retinol metabolism_Homo sapiens_hsa008301.11910576
53Fanconi anemia pathway_Homo sapiens_hsa034601.10231478
54Pyruvate metabolism_Homo sapiens_hsa006201.08714870
55Chemical carcinogenesis_Homo sapiens_hsa052041.06202193
56Synaptic vesicle cycle_Homo sapiens_hsa047211.05746377
57Central carbon metabolism in cancer_Homo sapiens_hsa052301.04520828
58Phenylalanine metabolism_Homo sapiens_hsa003601.02966077
59Tyrosine metabolism_Homo sapiens_hsa003501.02537433
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02212390
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01242546
62MicroRNAs in cancer_Homo sapiens_hsa052060.97282961
63Hippo signaling pathway_Homo sapiens_hsa043900.95994605
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95440822
65Oocyte meiosis_Homo sapiens_hsa041140.94819376
66Starch and sucrose metabolism_Homo sapiens_hsa005000.94393500
67Vitamin digestion and absorption_Homo sapiens_hsa049770.93845277
68N-Glycan biosynthesis_Homo sapiens_hsa005100.93692148
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88627667
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88447022
71Basal transcription factors_Homo sapiens_hsa030220.84377794
72Selenocompound metabolism_Homo sapiens_hsa004500.83178629
73Amphetamine addiction_Homo sapiens_hsa050310.82720250
74Fatty acid biosynthesis_Homo sapiens_hsa000610.82613898
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.81005747
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80159980
77Caffeine metabolism_Homo sapiens_hsa002320.79993058
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78587771
79Circadian entrainment_Homo sapiens_hsa047130.78515663
80ABC transporters_Homo sapiens_hsa020100.77451601
81Long-term potentiation_Homo sapiens_hsa047200.77303031
82Dopaminergic synapse_Homo sapiens_hsa047280.76064841
83Cocaine addiction_Homo sapiens_hsa050300.75917441
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75498463
85Long-term depression_Homo sapiens_hsa047300.74692484
86Insulin secretion_Homo sapiens_hsa049110.73736574
87RNA degradation_Homo sapiens_hsa030180.73445801
88Glycerolipid metabolism_Homo sapiens_hsa005610.73343098
89Endometrial cancer_Homo sapiens_hsa052130.72697280
90Base excision repair_Homo sapiens_hsa034100.72263631
91Small cell lung cancer_Homo sapiens_hsa052220.69590835
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.69402350
93Chronic myeloid leukemia_Homo sapiens_hsa052200.69102055
94Morphine addiction_Homo sapiens_hsa050320.69057673
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69013611
96Axon guidance_Homo sapiens_hsa043600.68026831
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67732686
98Serotonergic synapse_Homo sapiens_hsa047260.67568215
99Prostate cancer_Homo sapiens_hsa052150.67048778
100TGF-beta signaling pathway_Homo sapiens_hsa043500.63490319
101* Ether lipid metabolism_Homo sapiens_hsa005650.63018672
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62602651
103Homologous recombination_Homo sapiens_hsa034400.62479547
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62164290
105p53 signaling pathway_Homo sapiens_hsa041150.60163772
106Arginine and proline metabolism_Homo sapiens_hsa003300.59553111
107Colorectal cancer_Homo sapiens_hsa052100.59304612
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59191478
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.58881570
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58661194
111* Glycerophospholipid metabolism_Homo sapiens_hsa005640.58315629
112Glioma_Homo sapiens_hsa052140.58295044
113Wnt signaling pathway_Homo sapiens_hsa043100.57603149
114Renin secretion_Homo sapiens_hsa049240.57428371
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57291302
116Inositol phosphate metabolism_Homo sapiens_hsa005620.56684271
117Vibrio cholerae infection_Homo sapiens_hsa051100.55246634
118Cholinergic synapse_Homo sapiens_hsa047250.55225508
119Tight junction_Homo sapiens_hsa045300.54813569
120Non-small cell lung cancer_Homo sapiens_hsa052230.54668443
121Carbon metabolism_Homo sapiens_hsa012000.54645630
122Proteoglycans in cancer_Homo sapiens_hsa052050.53352056
123Salivary secretion_Homo sapiens_hsa049700.53258362
124Taste transduction_Homo sapiens_hsa047420.52938745
125Biosynthesis of amino acids_Homo sapiens_hsa012300.51931481
126Linoleic acid metabolism_Homo sapiens_hsa005910.51239071
127Alcoholism_Homo sapiens_hsa050340.50781796
128Viral carcinogenesis_Homo sapiens_hsa052030.50585688
129Olfactory transduction_Homo sapiens_hsa047400.50056333
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50055755
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49641756
132Thyroid hormone synthesis_Homo sapiens_hsa049180.49533734
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49071739
134Renin-angiotensin system_Homo sapiens_hsa046140.48906662
135Pancreatic cancer_Homo sapiens_hsa052120.48320518
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48183588
137Bladder cancer_Homo sapiens_hsa052190.47955814
138Insulin signaling pathway_Homo sapiens_hsa049100.45325779
139AMPK signaling pathway_Homo sapiens_hsa041520.44681414
140Ovarian steroidogenesis_Homo sapiens_hsa049130.44067571
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43290139
142Prion diseases_Homo sapiens_hsa050200.41918237
143Renal cell carcinoma_Homo sapiens_hsa052110.41020369
144Galactose metabolism_Homo sapiens_hsa000520.39408444
145Type II diabetes mellitus_Homo sapiens_hsa049300.38191068
146Sphingolipid metabolism_Homo sapiens_hsa006000.35527900
147Lysine degradation_Homo sapiens_hsa003100.35325372
148* Metabolic pathways_Homo sapiens_hsa011000.34547807
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32952552
150ErbB signaling pathway_Homo sapiens_hsa040120.32693535
151Gap junction_Homo sapiens_hsa045400.32132501
152Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31273045
153Glucagon signaling pathway_Homo sapiens_hsa049220.31179673
154Mineral absorption_Homo sapiens_hsa049780.31159936
155Protein export_Homo sapiens_hsa030600.30867749

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