EPOR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme biosynthetic process (GO:0006783)9.87832682
2oxygen transport (GO:0015671)9.24123933
3porphyrin-containing compound biosynthetic process (GO:0006779)9.15883609
4tetrapyrrole biosynthetic process (GO:0033014)8.14840630
5heme metabolic process (GO:0042168)8.01208934
6negative regulation of erythrocyte differentiation (GO:0045647)7.52517837
7porphyrin-containing compound metabolic process (GO:0006778)7.42842178
8erythrocyte maturation (GO:0043249)6.86657559
9erythrocyte development (GO:0048821)5.56278059
10megakaryocyte development (GO:0035855)5.32018197
11DNA deamination (GO:0045006)5.24910733
12ribosomal small subunit assembly (GO:0000028)5.20296443
13tetrapyrrole metabolic process (GO:0033013)4.82501164
14DNA strand elongation involved in DNA replication (GO:0006271)4.82307770
15DNA replication initiation (GO:0006270)4.80874876
16pigment biosynthetic process (GO:0046148)4.78403894
17telomere maintenance via semi-conservative replication (GO:0032201)4.78286528
18one-carbon compound transport (GO:0019755)4.73874516
19viral transcription (GO:0019083)4.68981815
20DNA strand elongation (GO:0022616)4.57307490
21neutrophil activation involved in immune response (GO:0002283)4.53987607
22translational termination (GO:0006415)4.50995557
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.43857025
24positive regulation of granulocyte differentiation (GO:0030854)4.20032566
25translational elongation (GO:0006414)4.13075513
26regulation of response to osmotic stress (GO:0047484)4.09557827
27pigment metabolic process (GO:0042440)4.08217244
28erythrocyte differentiation (GO:0030218)4.05755415
29DNA replication checkpoint (GO:0000076)4.04424499
30definitive hemopoiesis (GO:0060216)4.00874529
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.96392319
32embryonic hemopoiesis (GO:0035162)3.95571102
33cellular response to thyroid hormone stimulus (GO:0097067)3.95259083
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90978770
35protein autoprocessing (GO:0016540)3.88480590
36telomere maintenance via recombination (GO:0000722)3.87840230
37folic acid-containing compound biosynthetic process (GO:0009396)3.83432182
38CENP-A containing nucleosome assembly (GO:0034080)3.81349627
39cotranslational protein targeting to membrane (GO:0006613)3.81025293
40protein targeting to ER (GO:0045047)3.80639792
41response to lead ion (GO:0010288)3.78518159
42DNA unwinding involved in DNA replication (GO:0006268)3.76138289
43response to arsenic-containing substance (GO:0046685)3.66942973
44ribosomal small subunit biogenesis (GO:0042274)3.65174345
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64847989
46response to thyroid hormone (GO:0097066)3.62124952
47myeloid cell development (GO:0061515)3.61806822
48protein localization to endoplasmic reticulum (GO:0070972)3.61197399
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58774158
50chromatin remodeling at centromere (GO:0031055)3.58452727
51translational initiation (GO:0006413)3.56461343
52cellular response to arsenic-containing substance (GO:0071243)3.55968857
53deoxyribonucleotide biosynthetic process (GO:0009263)3.55657121
54proteasome assembly (GO:0043248)3.54843646
55regulation of platelet aggregation (GO:0090330)3.54800491
56deoxyribose phosphate biosynthetic process (GO:0046385)3.52767520
572-deoxyribonucleotide biosynthetic process (GO:0009265)3.52767520
58cellular protein complex disassembly (GO:0043624)3.52046607
59hemoglobin metabolic process (GO:0020027)3.49186569
60viral life cycle (GO:0019058)3.48459599
61gas transport (GO:0015669)3.47569878
62mitotic recombination (GO:0006312)3.45644906
63maturation of SSU-rRNA (GO:0030490)3.43380777
64response to methylmercury (GO:0051597)3.41920799
65DNA replication-independent nucleosome organization (GO:0034724)3.40801222
66DNA replication-independent nucleosome assembly (GO:0006336)3.40801222
67granulocyte differentiation (GO:0030851)3.39484749
68leukocyte migration involved in inflammatory response (GO:0002523)3.33178293
69protein localization to chromosome, centromeric region (GO:0071459)3.32365486
70hydrogen peroxide catabolic process (GO:0042744)3.31729146
71telomere maintenance via telomere lengthening (GO:0010833)3.30502823
72regulation of mast cell degranulation (GO:0043304)3.28250558
73protein localization to kinetochore (GO:0034501)3.21229850
74glycine transport (GO:0015816)3.18603707
75DNA replication-dependent nucleosome assembly (GO:0006335)3.18326353
76DNA replication-dependent nucleosome organization (GO:0034723)3.18326353
77iron ion import (GO:0097286)3.16785252
78pseudouridine synthesis (GO:0001522)3.15617648
79kinetochore organization (GO:0051383)3.15463703
80positive regulation of megakaryocyte differentiation (GO:0045654)3.15293997
81neutrophil activation (GO:0042119)3.13894353
82response to insecticide (GO:0017085)3.13088461
83iron-sulfur cluster assembly (GO:0016226)3.11660936
84metallo-sulfur cluster assembly (GO:0031163)3.11660936
85regulation of erythrocyte differentiation (GO:0045646)3.11616135
86protein complex disassembly (GO:0043241)3.11358655
87folic acid metabolic process (GO:0046655)3.07992904
88nucleotide-excision repair, DNA gap filling (GO:0006297)3.07036760
89formation of translation preinitiation complex (GO:0001731)3.05645103
90purine-containing compound salvage (GO:0043101)3.03885965
91IMP biosynthetic process (GO:0006188)3.03139261
92regulation of mast cell activation involved in immune response (GO:0033006)3.00362377
93platelet formation (GO:0030220)2.99863848
94translation (GO:0006412)2.99184298
95kinetochore assembly (GO:0051382)2.98627572
96regulation of integrin-mediated signaling pathway (GO:2001044)2.97905952
97macromolecular complex disassembly (GO:0032984)2.93255138
98platelet aggregation (GO:0070527)2.92539258
99modulation by virus of host process (GO:0019054)2.92250708
100lysine metabolic process (GO:0006553)2.92185066
101lysine catabolic process (GO:0006554)2.92185066
102mitotic sister chromatid segregation (GO:0000070)2.92137370
103positive regulation of insulin receptor signaling pathway (GO:0046628)2.91849086
104gonadal mesoderm development (GO:0007506)2.91831792
105granulocyte activation (GO:0036230)2.91518816
106cofactor biosynthetic process (GO:0051188)2.90995921
107mitotic nuclear envelope disassembly (GO:0007077)2.90491958
108negative regulation of RNA splicing (GO:0033119)2.88121654
109ribosomal large subunit biogenesis (GO:0042273)2.87000849
110protein-cofactor linkage (GO:0018065)2.86703907
111thrombin receptor signaling pathway (GO:0070493)2.86337269
112histone exchange (GO:0043486)2.86057454
113ribonucleoprotein complex biogenesis (GO:0022613)2.84158209
114innate immune response in mucosa (GO:0002227)2.82343171
115negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81575875
116pteridine-containing compound biosynthetic process (GO:0042559)2.81509024
117nuclear-transcribed mRNA catabolic process (GO:0000956)2.80284990
118potassium ion export (GO:0071435)2.75442574
119spliceosomal snRNP assembly (GO:0000387)2.71394095
120positive regulation of bone remodeling (GO:0046852)2.70180898
121positive regulation of bone resorption (GO:0045780)2.70180898
122RNA catabolic process (GO:0006401)2.68740724
123oxidative phosphorylation (GO:0006119)2.67707731
124nuclear envelope disassembly (GO:0051081)2.67534367
125membrane disassembly (GO:0030397)2.67534367
126chromatin assembly or disassembly (GO:0006333)2.67031850
127positive regulation of erythrocyte differentiation (GO:0045648)2.64782332
128mesodermal cell differentiation (GO:0048333)2.57039158
129bicarbonate transport (GO:0015701)2.55579386
130antibacterial humoral response (GO:0019731)2.55464758
131leukocyte degranulation (GO:0043299)2.52722798
132negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.51938728
133disruption of cells of other organism (GO:0044364)2.51855330
134killing of cells of other organism (GO:0031640)2.51855330
135viral protein processing (GO:0019082)2.51597413
136negative regulation of viral entry into host cell (GO:0046597)2.51588668
137deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.51003834
138negative regulation of focal adhesion assembly (GO:0051895)2.49471869
139negative regulation of cell junction assembly (GO:1901889)2.49471869
140negative regulation of adherens junction organization (GO:1903392)2.49471869
141protein targeting to plasma membrane (GO:0072661)2.48953525
142defense response to fungus (GO:0050832)2.48873070
143pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.48535880
144regulation of granulocyte differentiation (GO:0030852)2.47789185
145negative regulation of DNA-templated transcription, elongation (GO:0032785)2.46877279
146regulation of platelet activation (GO:0010543)2.45949864
147positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.45110157
148regulation of myeloid leukocyte mediated immunity (GO:0002886)2.44560030
149regulation of leukocyte degranulation (GO:0043300)2.44293834
150positive regulation of fibroblast migration (GO:0010763)2.44147166
151N-acetylneuraminate metabolic process (GO:0006054)2.43349016
1523-UTR-mediated mRNA stabilization (GO:0070935)2.43312368
153cellular response to virus (GO:0098586)2.41162359
154adenosine receptor signaling pathway (GO:0001973)2.40375596
155negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.40364188
156regulation of amyloid precursor protein catabolic process (GO:1902991)2.39561136
157mucosal immune response (GO:0002385)2.38249933
158negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.37761796
159endothelium development (GO:0003158)2.37718900
160hemopoiesis (GO:0030097)2.37502245
161regulation of memory T cell differentiation (GO:0043380)2.35375953
162poly(A)+ mRNA export from nucleus (GO:0016973)2.34735796
163regulation of mast cell activation (GO:0033003)2.34670061
164hepatocyte apoptotic process (GO:0097284)2.32076835
165protein maturation by protein folding (GO:0022417)2.31371159
166blood coagulation, intrinsic pathway (GO:0007597)2.30692048
167proline biosynthetic process (GO:0006561)2.30385499
168antimicrobial humoral response (GO:0019730)2.28749321
169protoporphyrinogen IX metabolic process (GO:0046501)12.0539848
170protoporphyrinogen IX biosynthetic process (GO:0006782)11.7187604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.89670450
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.62484038
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.65500906
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.44977255
5GATA1_22025678_ChIP-Seq_K562_Human3.31620795
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25068560
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67122208
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66994320
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62810969
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55563431
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.55415446
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.51120690
13TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.47623678
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.42100192
15SCL_19346495_ChIP-Seq_HPC-7_Human2.31334042
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30633477
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28140995
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26075174
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24092340
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23515371
21* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20354737
22* GATA1_19941827_ChIP-Seq_MEL_Mouse2.14700550
23XRN2_22483619_ChIP-Seq_HELA_Human2.09112965
24GATA1_22383799_ChIP-Seq_G1ME_Mouse2.08306106
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03826049
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01575058
27VDR_23849224_ChIP-Seq_CD4+_Human1.99128003
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98177268
29GATA1_19941826_ChIP-Seq_K562_Human1.96945886
30NCOR1_26117541_ChIP-Seq_K562_Human1.94213038
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93801975
32SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.93485210
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92731305
34MYC_22102868_ChIP-Seq_BL_Human1.85826049
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.84300135
36DCP1A_22483619_ChIP-Seq_HELA_Human1.80670661
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77949514
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77715525
39KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.76852073
40AR_21909140_ChIP-Seq_LNCAP_Human1.76490374
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76066665
42FOXP3_21729870_ChIP-Seq_TREG_Human1.75485102
43GABP_19822575_ChIP-Seq_HepG2_Human1.74706248
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.71072282
45* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68928680
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62686753
47* ELK3_25401928_ChIP-Seq_HUVEC_Human1.62559987
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61671193
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.59163703
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56954314
51VDR_21846776_ChIP-Seq_THP-1_Human1.56751104
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.55787712
53* MAF_26560356_Chip-Seq_TH1_Human1.53333260
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52816021
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51894559
56* TCF7_22412390_ChIP-Seq_EML_Mouse1.50815252
57* UTX_26944678_Chip-Seq_JUKART_Human1.50534835
58CIITA_25753668_ChIP-Seq_RAJI_Human1.48696407
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47752091
60* TTF2_22483619_ChIP-Seq_HELA_Human1.47485147
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43023458
62SPI1_23127762_ChIP-Seq_K562_Human1.40281776
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38867005
64* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38618848
65* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38343486
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38174000
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.36820281
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35685131
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35549887
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35215685
71LXR_22292898_ChIP-Seq_THP-1_Human1.32038473
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31242188
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30306730
74VDR_24763502_ChIP-Seq_THP-1_Human1.28973620
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27974352
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27829674
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26822097
78KDM5A_27292631_Chip-Seq_BREAST_Human1.26561001
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26192305
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25760063
81P68_20966046_ChIP-Seq_HELA_Human1.25563369
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25023686
83BCOR_27268052_Chip-Seq_Bcells_Human1.24651700
84BCL6_27268052_Chip-Seq_Bcells_Human1.24192496
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23760768
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21557068
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20871745
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20534441
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18304672
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17123257
91ELK1_19687146_ChIP-ChIP_HELA_Human1.17068201
92RXR_22158963_ChIP-Seq_LIVER_Mouse1.16906279
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16564433
94MAF_26560356_Chip-Seq_TH2_Human1.16079389
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15642202
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15016127
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12789611
98* KDM2B_26808549_Chip-Seq_DND41_Human1.12197278
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11874831
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10915268
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10789986
102ZNF263_19887448_ChIP-Seq_K562_Human1.10564124
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07891348
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07321526
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06767348
106GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06636937
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05872380
108CTCF_21964334_Chip-Seq_Bcells_Human1.05474081
109* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04040840
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03070073
111TFEB_21752829_ChIP-Seq_HELA_Human1.02992543
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01882211
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01795200
114* MYB_26560356_Chip-Seq_TH1_Human1.01759528
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01071747
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00682065
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99493537
118SPI1_20517297_ChIP-Seq_HL60_Human0.98899541
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98577605
120GATA2_19941826_ChIP-Seq_K562_Human0.98551438
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98156800
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98156333
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.97945730
124* RACK7_27058665_Chip-Seq_MCF-7_Human0.97114608
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97010854
126ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96816320
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96190099
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95852838
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94415003
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93154717
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92861782
132YY1_22570637_ChIP-Seq_MALME-3M_Human0.92161092
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.91805734
134LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90504539
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.89147644
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.88885925
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85144161
138SPI1_23547873_ChIP-Seq_NB4_Human0.84490798
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84417597
140CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84212396
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84203153
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83374204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo9.64519664
2MP0004147_increased_porphyrin_level9.21208762
3MP0006054_spinal_hemorrhage4.55357694
4MP0005397_hematopoietic_system_phenotyp3.56453658
5MP0001545_abnormal_hematopoietic_system3.56453658
6MP0003111_abnormal_nucleus_morphology3.54284614
7MP0003693_abnormal_embryo_hatching3.16525120
8MP0010094_abnormal_chromosome_stability3.11821331
9MP0003303_peritoneal_inflammation2.92337319
10MP0004957_abnormal_blastocyst_morpholog2.69657994
11MP0002396_abnormal_hematopoietic_system2.68757405
12MP0003077_abnormal_cell_cycle2.61659569
13MP0008057_abnormal_DNA_replication2.54281488
14MP0003806_abnormal_nucleotide_metabolis2.38585981
15MP0002132_abnormal_respiratory_system2.13610419
16MP0006036_abnormal_mitochondrial_physio2.10404835
17MP0005636_abnormal_mineral_homeostasis2.08268739
18MP0005058_abnormal_lysosome_morphology2.04214820
19MP0009278_abnormal_bone_marrow2.01709135
20MP0008995_early_reproductive_senescence2.00175276
21MP0008058_abnormal_DNA_repair1.97872142
22MP0003172_abnormal_lysosome_physiology1.92609536
23MP0005083_abnormal_biliary_tract1.89746904
24MP0000490_abnormal_crypts_of1.87512095
25MP0003186_abnormal_redox_activity1.74665044
26MP0008007_abnormal_cellular_replicative1.74587750
27MP0008260_abnormal_autophagy1.60307520
28MP0008004_abnormal_stomach_pH1.53514588
29MP0009333_abnormal_splenocyte_physiolog1.49291685
30* MP0002398_abnormal_bone_marrow1.40552180
31MP0005377_hearing/vestibular/ear_phenot1.39328476
32MP0003878_abnormal_ear_physiology1.39328476
33MP0002877_abnormal_melanocyte_morpholog1.36182209
34MP0000313_abnormal_cell_death1.26085697
35MP0003436_decreased_susceptibility_to1.24786475
36MP0000350_abnormal_cell_proliferation1.24262843
37* MP0002722_abnormal_immune_system1.23825444
38MP0004808_abnormal_hematopoietic_stem1.22717912
39* MP0000689_abnormal_spleen_morphology1.22334915
40MP0008932_abnormal_embryonic_tissue1.20913302
41MP0000343_altered_response_to1.18731052
42MP0008872_abnormal_physiological_respon1.17725827
43MP0002139_abnormal_hepatobiliary_system1.17568209
44MP0003879_abnormal_hair_cell1.12637575
45MP0005464_abnormal_platelet_physiology1.12029039
46MP0003566_abnormal_cell_adhesion1.11160251
47* MP0002429_abnormal_blood_cell1.10151290
48MP0001730_embryonic_growth_arrest1.06985449
49MP0002019_abnormal_tumor_incidence1.03733661
50MP0005451_abnormal_body_composition1.03403355
51MP0003300_gastrointestinal_ulcer1.00378206
52MP0005220_abnormal_exocrine_pancreas0.99656412
53MP0006035_abnormal_mitochondrial_morpho0.98522906
54MP0000685_abnormal_immune_system0.96366026
55MP0010307_abnormal_tumor_latency0.95035755
56* MP0002080_prenatal_lethality0.94462592
57MP0003724_increased_susceptibility_to0.91383782
58MP0009931_abnormal_skin_appearance0.90682636
59MP0002419_abnormal_innate_immunity0.89248778
60MP0000703_abnormal_thymus_morphology0.88333115
61MP0000015_abnormal_ear_pigmentation0.85662929
62MP0000358_abnormal_cell_content/0.83452063
63MP0001661_extended_life_span0.83105743
64MP0003786_premature_aging0.82483638
65MP0005000_abnormal_immune_tolerance0.82405934
66MP0001529_abnormal_vocalization0.81276220
67MP0005671_abnormal_response_to0.80163560
68MP0003866_abnormal_defecation0.79700283
69* MP0004215_abnormal_myocardial_fiber0.79369531
70MP0001697_abnormal_embryo_size0.78100887
71MP0008770_decreased_survivor_rate0.77581234
72MP0009785_altered_susceptibility_to0.77095077
73MP0003195_calcinosis0.76657857
74MP0000749_muscle_degeneration0.76154891
75MP0000465_gastrointestinal_hemorrhage0.72998295
76MP0009697_abnormal_copulation0.72069414
77MP0005084_abnormal_gallbladder_morpholo0.71793866
78MP0009764_decreased_sensitivity_to0.71550841
79MP0002420_abnormal_adaptive_immunity0.71506967
80MP0001764_abnormal_homeostasis0.71387506
81MP0001819_abnormal_immune_cell0.70768139
82MP0001853_heart_inflammation0.68286976
83MP0003123_paternal_imprinting0.67181377
84MP0005501_abnormal_skin_physiology0.67010442
85MP0002166_altered_tumor_susceptibility0.66734588
86* MP0000598_abnormal_liver_morphology0.66517766
87MP0001845_abnormal_inflammatory_respons0.65590388
88MP0000716_abnormal_immune_system0.65352149
89MP0003045_fibrosis0.65268895
90MP0004947_skin_inflammation0.65051650
91MP0003943_abnormal_hepatobiliary_system0.65034886
92MP0009379_abnormal_foot_pigmentation0.64908506
93MP0005584_abnormal_enzyme/coenzyme_acti0.64824093
94MP0010352_gastrointestinal_tract_polyps0.64599735
95MP0005075_abnormal_melanosome_morpholog0.64052569
96MP0001756_abnormal_urination0.63959094
97* MP0002086_abnormal_extraembryonic_tissu0.63925956
98* MP0009763_increased_sensitivity_to0.63805230
99MP0005319_abnormal_enzyme/_coenzyme0.63744282
100MP0009840_abnormal_foam_cell0.63743507
101MP0001915_intracranial_hemorrhage0.63742640
102MP0002095_abnormal_skin_pigmentation0.63223492
103* MP0000609_abnormal_liver_physiology0.63042327
104MP0005167_abnormal_blood-brain_barrier0.62077355
105MP0008469_abnormal_protein_level0.61963057
106MP0010329_abnormal_lipoprotein_level0.61606935
107MP0003191_abnormal_cellular_cholesterol0.61187349
108MP0002138_abnormal_hepatobiliary_system0.60523700
109MP0005647_abnormal_sex_gland0.60512921
110MP0005085_abnormal_gallbladder_physiolo0.60319297
111MP0001851_eye_inflammation0.60208100
112MP0003763_abnormal_thymus_physiology0.60161603
113MP0002723_abnormal_immune_serum0.60016932
114MP0001243_abnormal_dermal_layer0.59661854
115MP0005266_abnormal_metabolism0.59175750
116MP0009642_abnormal_blood_homeostasis0.59095135
117MP0004510_myositis0.58781145
118MP0002118_abnormal_lipid_homeostasis0.58270878
119MP0001663_abnormal_digestive_system0.57451132
120MP0005380_embryogenesis_phenotype0.55409126
121MP0001672_abnormal_embryogenesis/_devel0.55409126
122MP0003638_abnormal_response/metabolism_0.55387711
123MP0003984_embryonic_growth_retardation0.54683738
124MP0005384_cellular_phenotype0.54209400
125MP0003828_pulmonary_edema0.53630970
126MP0001533_abnormal_skeleton_physiology0.53294317
127MP0005535_abnormal_body_temperature0.52156710
128MP0002088_abnormal_embryonic_growth/wei0.51822084
129MP0005076_abnormal_cell_differentiation0.51136498
130MP0002405_respiratory_system_inflammati0.50013689
131MP0003718_maternal_effect0.49568762
132MP0005621_abnormal_cell_physiology0.48100450
133MP0004043_abnormal_pH_regulation0.46006390
134MP0003567_abnormal_fetal_cardiomyocyte0.45440423
135MP0008873_increased_physiological_sensi0.44796570
136MP0009643_abnormal_urine_homeostasis0.43861860
137MP0008789_abnormal_olfactory_epithelium0.43298242
138MP0002102_abnormal_ear_morphology0.43284569
139MP0001873_stomach_inflammation0.42775196
140MP0005174_abnormal_tail_pigmentation0.42572800
141MP0000477_abnormal_intestine_morphology0.40614460
142MP0002970_abnormal_white_adipose0.39789324
143MP0005394_taste/olfaction_phenotype0.39690032
144MP0005499_abnormal_olfactory_system0.39690032
145MP0005025_abnormal_response_to0.39345281
146MP0010368_abnormal_lymphatic_system0.39239173
147MP0000858_altered_metastatic_potential0.38705195
148MP0009765_abnormal_xenobiotic_induced0.37786584

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)8.83294735
2Abnormal number of erythroid precursors (HP:0012131)8.56310788
3Abnormality of cells of the erythroid lineage (HP:0012130)8.08248066
4Reticulocytosis (HP:0001923)7.37207614
5Acanthocytosis (HP:0001927)7.20559048
6Abnormality of reticulocytes (HP:0004312)5.95606895
7Abnormal hemoglobin (HP:0011902)5.21070563
8Hyperbilirubinemia (HP:0002904)5.05829703
9Diaphragmatic weakness (HP:0009113)4.76061219
10Increased mean platelet volume (HP:0011877)4.75934671
11Abnormal platelet volume (HP:0011876)4.68052940
12Petechiae (HP:0000967)4.45439564
13Increased serum ferritin (HP:0003281)4.42573520
14Menorrhagia (HP:0000132)4.39982062
15Birth length less than 3rd percentile (HP:0003561)4.21593969
16Paralysis (HP:0003470)4.17349112
17Pallor (HP:0000980)4.11521655
18Cholelithiasis (HP:0001081)4.03869107
19Polycythemia (HP:0001901)3.87318307
20Abnormality of iron homeostasis (HP:0011031)3.86857368
21Hypochromic microcytic anemia (HP:0004840)3.65083248
22Insomnia (HP:0100785)3.64372816
23Abnormality of transition element cation homeostasis (HP:0011030)3.54617861
24Abnormal gallbladder morphology (HP:0012437)3.54169831
25Prolonged bleeding time (HP:0003010)3.48389515
26Reticulocytopenia (HP:0001896)3.43872283
27Macrocytic anemia (HP:0001972)3.39457862
28Cutaneous photosensitivity (HP:0000992)3.30335091
29Gingival bleeding (HP:0000225)3.29219675
30Short middle phalanx of the 5th finger (HP:0004220)3.25975393
31Aplastic anemia (HP:0001915)3.17301555
32Microcytic anemia (HP:0001935)3.00886393
33Ileus (HP:0002595)3.00065850
34Cholecystitis (HP:0001082)2.98172776
35Abnormal gallbladder physiology (HP:0012438)2.98172776
36Nonimmune hydrops fetalis (HP:0001790)2.72592242
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71738144
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71738144
39Nausea (HP:0002018)2.70141812
40Osteomalacia (HP:0002749)2.65940878
41Hypochromic anemia (HP:0001931)2.63860811
42Spontaneous hematomas (HP:0007420)2.52587973
43Toxemia of pregnancy (HP:0100603)2.48699732
44Abnormality of the gallbladder (HP:0005264)2.48651909
45Oral leukoplakia (HP:0002745)2.41977641
46Hepatosplenomegaly (HP:0001433)2.37454996
47Hepatocellular carcinoma (HP:0001402)2.29762466
48Hepatocellular necrosis (HP:0001404)2.27521280
49Optic neuritis (HP:0100653)2.24123092
50Retrobulbar optic neuritis (HP:0100654)2.24123092
51Gastrointestinal infarctions (HP:0005244)2.21429298
52Anorexia (HP:0002039)2.20668620
53Abnormal platelet function (HP:0011869)2.20502136
54Impaired platelet aggregation (HP:0003540)2.20502136
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19451722
56Increased serum lactate (HP:0002151)2.19407384
57Hyponatremia (HP:0002902)2.19151631
58Pancreatic islet-cell hyperplasia (HP:0004510)2.13818763
59Orchitis (HP:0100796)2.12590518
60Myositis (HP:0100614)2.12371199
61Breast hypoplasia (HP:0003187)2.10654813
62Mitochondrial inheritance (HP:0001427)2.10253265
63Hyperlipoproteinemia (HP:0010980)2.06975810
64Hepatic necrosis (HP:0002605)2.06588731
65Arterial thrombosis (HP:0004420)2.06366828
66Muscle fibrillation (HP:0010546)2.04426080
67Abnormal mitochondria in muscle tissue (HP:0008316)2.03326870
68Microretrognathia (HP:0000308)2.02762038
69Brushfield spots (HP:0001088)2.01721319
70Abnormality of the pancreatic islet cells (HP:0006476)2.00172848
71Abnormality of endocrine pancreas physiology (HP:0012093)2.00172848
72* Abnormality of the heme biosynthetic pathway (HP:0010472)13.2690689
73Hypertensive crisis (HP:0100735)1.99899253
74Bruising susceptibility (HP:0000978)1.99362157
75Acute necrotizing encephalopathy (HP:0006965)1.99219613
76Severe visual impairment (HP:0001141)1.98471270
77Abnormality of macrophages (HP:0004311)1.98448461
78Tetraparesis (HP:0002273)1.98416602
79Increased CSF lactate (HP:0002490)1.98084759
80Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.97322881
81Stomatitis (HP:0010280)1.96802611
82Hypoplasia of the pons (HP:0012110)1.96345200
83Keratoconjunctivitis sicca (HP:0001097)1.93893088
84Delusions (HP:0000746)1.93243442
85Abnormality of sodium homeostasis (HP:0010931)1.91555381
86Ventricular fibrillation (HP:0001663)1.90804144
87Orthostatic hypotension (HP:0001278)1.90666205
88Dysautonomia (HP:0002459)1.90213325
893-Methylglutaconic aciduria (HP:0003535)1.89275904
90Abnormality of the pons (HP:0007361)1.88140641
91Broad palm (HP:0001169)1.87418312
92Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86681367
93Myelodysplasia (HP:0002863)1.86384572
94Cerebral palsy (HP:0100021)1.86324911
95Hemorrhage of the eye (HP:0011885)1.86281509
96Recurrent abscess formation (HP:0002722)1.84987489
97Hyperthyroidism (HP:0000836)1.84275897
98Basal cell carcinoma (HP:0002671)1.84244334
99* Epistaxis (HP:0000421)1.84233252
100Keratoconjunctivitis (HP:0001096)1.83257606
101Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.81110119
102Albinism (HP:0001022)1.80133141
103Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77170903
104Hypertriglyceridemia (HP:0002155)1.77079576
105Increased intramyocellular lipid droplets (HP:0012240)1.76673111
106Episodic fever (HP:0001954)1.74695444
107Duodenal stenosis (HP:0100867)1.73660552
108Small intestinal stenosis (HP:0012848)1.73660552
109Multiple enchondromatosis (HP:0005701)1.73625788
110Purpura (HP:0000979)1.72716160
111Lactic acidosis (HP:0003128)1.72451377
112Abnormal spermatogenesis (HP:0008669)1.70963127
113Visual hallucinations (HP:0002367)1.70931152
114Tongue fasciculations (HP:0001308)1.70455469
115Myocardial infarction (HP:0001658)1.69448865
116Pustule (HP:0200039)1.68959894
117Gastrointestinal dysmotility (HP:0002579)1.67855376
118Increased muscle lipid content (HP:0009058)1.67062331
119Pancytopenia (HP:0001876)1.66109541
120Selective tooth agenesis (HP:0001592)1.65479978
121Generalized hyperpigmentation (HP:0007440)1.65380570
122Encephalitis (HP:0002383)1.64219206
123Acute encephalopathy (HP:0006846)1.62329239
124Exertional dyspnea (HP:0002875)1.60671312
125Type I transferrin isoform profile (HP:0003642)1.60604526
126Cerebral hypomyelination (HP:0006808)1.59912249
127Global brain atrophy (HP:0002283)1.59570733
128Hypophosphatemic rickets (HP:0004912)1.59356412
129Short 5th finger (HP:0009237)1.58859877
130Abnormality of the fingertips (HP:0001211)1.58482238
131Hypopigmented skin patches (HP:0001053)1.57632242
132Cerebellar dysplasia (HP:0007033)1.57359974
133Paresthesia (HP:0003401)1.57288301
134Irregular epiphyses (HP:0010582)1.56793065
135Eczematoid dermatitis (HP:0000976)1.56767937
136Cortical visual impairment (HP:0100704)1.56766916
137Splenomegaly (HP:0001744)1.56513043
138Abnormality of lateral ventricle (HP:0030047)1.55883501
139Abnormality of dental color (HP:0011073)1.55344559
140Chronic obstructive pulmonary disease (HP:0006510)1.54596894
141Obstructive lung disease (HP:0006536)1.54596894
142Recurrent bacterial skin infections (HP:0005406)1.54532147
143Lipid accumulation in hepatocytes (HP:0006561)1.53939035
144Azoospermia (HP:0000027)1.53477483
145Increased hepatocellular lipid droplets (HP:0006565)1.53352870
146Reduced antithrombin III activity (HP:0001976)1.53347652
147Acute hepatic failure (HP:0006554)1.52730136
148Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.52501776
149Cafe-au-lait spot (HP:0000957)1.51922518
150Onycholysis (HP:0001806)1.50426975
151Joint swelling (HP:0001386)1.50414696
152Progressive muscle weakness (HP:0003323)1.48853820
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.48598301
154Abnormality of the preputium (HP:0100587)1.48393103
155* Thrombophlebitis (HP:0004418)1.47148086
156Hypoparathyroidism (HP:0000829)1.44858911
157Osteomyelitis (HP:0002754)1.44416193
158Homocystinuria (HP:0002156)1.43804985
159Abnormality of homocysteine metabolism (HP:0010919)1.43804985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.43953689
2NME24.21290014
3PRPF4B4.06306089
4CDC73.53865990
5BUB13.10688717
6KDR3.07660625
7WEE12.91259269
8BMX2.89142818
9VRK12.65022247
10SCYL22.55390606
11STK162.53954288
12RIPK42.48678961
13MST42.41877162
14DYRK32.26763987
15TLK12.20138981
16NEK22.19924022
17BRSK12.12770579
18ACVR1B2.01696168
19ZAP701.91903212
20MAP3K31.81837880
21MAP3K111.76777366
22BRSK21.74694236
23NEK11.72852225
24EEF2K1.72592868
25PIM21.71882458
26MAP3K101.71349425
27PTK2B1.70649114
28CDK191.65403957
29STK101.64207103
30HIPK21.52332779
31STK41.48236173
32MAP2K61.45985229
33SIK11.39319719
34MAP3K11.36524904
35MAPKAPK51.33806814
36ERN11.33244428
37TRPM71.28570084
38SRPK11.28013377
39ATR1.25879950
40BTK1.25795564
41MAP3K81.23999099
42AURKA1.23463890
43PLK11.23343628
44AURKB1.21265912
45MAP4K11.15607125
46SIK31.14476695
47TGFBR21.12378542
48MAP2K31.11820751
49TTK1.11060309
50SMG11.10739805
51MAPK111.09942595
52MATK1.07215377
53LRRK21.06022429
54CDK41.04458472
55CCNB11.03438211
56CDK71.02446314
57RPS6KA41.02127198
58MARK31.01115578
59FES1.00764898
60TYK20.99587825
61TEC0.96949627
62MAP3K50.96266277
63PIM10.94416982
64EIF2AK30.93637234
65NME10.92411942
66RPS6KB20.91257371
67CDK80.90005979
68CHEK20.88458740
69IRAK40.86636384
70ABL20.86104042
71EPHB10.86024056
72FLT30.83446732
73HCK0.81010975
74TIE10.80597776
75PKN20.78958635
76MAPKAPK30.78219299
77MAP2K10.77946843
78TSSK60.77634497
79TAOK10.76536952
80CHEK10.75514070
81FGR0.74764802
82DAPK10.74217925
83TGFBR10.73567679
84PDPK10.73272826
85ATM0.70980622
86RAF10.66731244
87TNIK0.66659956
88PRKD20.65758206
89GRK50.63484780
90EPHA30.63315261
91MARK20.63205923
92DAPK20.61878741
93SYK0.61583340
94TRIB30.61568741
95BRAF0.61035734
96SIK20.60374553
97CLK10.60261126
98RPS6KA50.59645159
99GRK60.59608787
100CSNK2A10.59319167
101CSNK2A20.57911147
102PDK10.55375671
103TESK20.55122320
104PAK40.53938487
105IRAK10.53844967
106IKBKE0.52993516
107TAOK20.52890318
108CDK120.51995134
109* LYN0.51066609
110IKBKB0.49620784
111ILK0.49044999
112MKNK10.48689060
113RPS6KA20.48501916
114JAK30.48484440
115EIF2AK20.48166129
116CDK20.47766589
117BCKDK0.47045995
118ICK0.46055931
119ZAK0.45453597
120PBK0.44232442
121VRK20.42940202
122TBK10.42554124
123BLK0.40643259
124STK30.39924981
125RET0.39697944
126WNK10.39682104
127MAPKAPK20.39251282
128MAP3K60.39133921
129PRKAA20.38988765
130PAK10.38772759
131IRAK20.38576261
132MAPK120.37995600
133MUSK0.37397660
134FRK0.36925550
135PLK30.36454035
136CDK10.35185679
137CDK11A0.33509870
138RPS6KA60.33167683
139TAOK30.32687158
140RPS6KC10.32281144
141RPS6KL10.32281144
142CDK60.32202446
143TNK20.31780074
144PRKDC0.31641742
145AKT10.31073560
146PRKACG0.30688649
147KIT0.30211645
148MAP2K40.30063364
149MAP3K70.29907501
150AKT20.29540136
151PLK40.27153791

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.85773585
2DNA replication_Homo sapiens_hsa030305.62795005
3Ribosome_Homo sapiens_hsa030104.35190216
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.01948126
5Mismatch repair_Homo sapiens_hsa034303.51194859
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.74354453
7Spliceosome_Homo sapiens_hsa030402.65714368
8Base excision repair_Homo sapiens_hsa034102.64899649
9Nucleotide excision repair_Homo sapiens_hsa034202.61764286
10Pyrimidine metabolism_Homo sapiens_hsa002402.54151105
11Proteasome_Homo sapiens_hsa030502.48763696
12Collecting duct acid secretion_Homo sapiens_hsa049662.43969242
13Cell cycle_Homo sapiens_hsa041102.39987480
14Homologous recombination_Homo sapiens_hsa034402.35560829
15One carbon pool by folate_Homo sapiens_hsa006702.31593074
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.29358009
17RNA polymerase_Homo sapiens_hsa030202.28966862
18Systemic lupus erythematosus_Homo sapiens_hsa053222.19147973
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16927780
20Sulfur relay system_Homo sapiens_hsa041222.15547241
21Regulation of autophagy_Homo sapiens_hsa041401.99609863
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98004404
23RNA transport_Homo sapiens_hsa030131.95304034
24Non-homologous end-joining_Homo sapiens_hsa034501.76598066
25Nitrogen metabolism_Homo sapiens_hsa009101.73955064
26Parkinsons disease_Homo sapiens_hsa050121.72584736
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.66126658
28Fanconi anemia pathway_Homo sapiens_hsa034601.58956345
29Vitamin B6 metabolism_Homo sapiens_hsa007501.52868070
30Pancreatic cancer_Homo sapiens_hsa052121.45366522
31p53 signaling pathway_Homo sapiens_hsa041151.42571038
32RNA degradation_Homo sapiens_hsa030181.41143512
33African trypanosomiasis_Homo sapiens_hsa051431.40418646
34Fatty acid elongation_Homo sapiens_hsa000621.34389163
35Oxidative phosphorylation_Homo sapiens_hsa001901.32291904
36Purine metabolism_Homo sapiens_hsa002301.28930173
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27714742
38Folate biosynthesis_Homo sapiens_hsa007901.26160742
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25083652
40Huntingtons disease_Homo sapiens_hsa050161.24403436
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.23384312
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.17613264
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12750745
44Selenocompound metabolism_Homo sapiens_hsa004501.11126084
45mTOR signaling pathway_Homo sapiens_hsa041501.09963510
46Alcoholism_Homo sapiens_hsa050341.04024503
47Other glycan degradation_Homo sapiens_hsa005111.02556070
48Pentose phosphate pathway_Homo sapiens_hsa000301.01965809
49Osteoclast differentiation_Homo sapiens_hsa043801.01616937
50Basal transcription factors_Homo sapiens_hsa030221.01437090
51Fructose and mannose metabolism_Homo sapiens_hsa000511.00167550
52ABC transporters_Homo sapiens_hsa020100.96254403
53B cell receptor signaling pathway_Homo sapiens_hsa046620.96141218
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93483864
55Endocytosis_Homo sapiens_hsa041440.91856542
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88629809
57* Jak-STAT signaling pathway_Homo sapiens_hsa046300.87976162
58Herpes simplex infection_Homo sapiens_hsa051680.84588060
59Alzheimers disease_Homo sapiens_hsa050100.83346218
60Lysosome_Homo sapiens_hsa041420.82608515
61Type II diabetes mellitus_Homo sapiens_hsa049300.82209649
62Caffeine metabolism_Homo sapiens_hsa002320.78261918
63Insulin signaling pathway_Homo sapiens_hsa049100.78157916
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77082823
65Protein export_Homo sapiens_hsa030600.76830745
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.75693455
67Viral carcinogenesis_Homo sapiens_hsa052030.75185036
68Glutathione metabolism_Homo sapiens_hsa004800.74576046
69Biosynthesis of amino acids_Homo sapiens_hsa012300.74386042
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73107536
71HIF-1 signaling pathway_Homo sapiens_hsa040660.72853042
72mRNA surveillance pathway_Homo sapiens_hsa030150.72525193
73Pyruvate metabolism_Homo sapiens_hsa006200.68819723
74Endometrial cancer_Homo sapiens_hsa052130.67603760
75FoxO signaling pathway_Homo sapiens_hsa040680.66578496
76Carbon metabolism_Homo sapiens_hsa012000.64730027
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64675822
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64476808
79Bladder cancer_Homo sapiens_hsa052190.63258469
80Shigellosis_Homo sapiens_hsa051310.63129356
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62304143
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61968607
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61913698
84Sphingolipid metabolism_Homo sapiens_hsa006000.61049576
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61006209
86VEGF signaling pathway_Homo sapiens_hsa043700.60540717
87N-Glycan biosynthesis_Homo sapiens_hsa005100.60009711
88Arachidonic acid metabolism_Homo sapiens_hsa005900.59813318
89Oocyte meiosis_Homo sapiens_hsa041140.59635704
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58881971
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58179084
92Epstein-Barr virus infection_Homo sapiens_hsa051690.58027663
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56842465
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54145507
95Renal cell carcinoma_Homo sapiens_hsa052110.54098997
96Inositol phosphate metabolism_Homo sapiens_hsa005620.53999442
97Notch signaling pathway_Homo sapiens_hsa043300.53825644
98Metabolic pathways_Homo sapiens_hsa011000.53067172
99Hepatitis C_Homo sapiens_hsa051600.51997499
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50509195
101Fatty acid metabolism_Homo sapiens_hsa012120.49408407
102Apoptosis_Homo sapiens_hsa042100.48873163
103Small cell lung cancer_Homo sapiens_hsa052220.48750424
104Chemokine signaling pathway_Homo sapiens_hsa040620.47393786
105Leishmaniasis_Homo sapiens_hsa051400.47032668
106Insulin resistance_Homo sapiens_hsa049310.46074094
107Prolactin signaling pathway_Homo sapiens_hsa049170.45068632
108Malaria_Homo sapiens_hsa051440.44999139
109* Hematopoietic cell lineage_Homo sapiens_hsa046400.44478542
110Thyroid cancer_Homo sapiens_hsa052160.43940258
111Prostate cancer_Homo sapiens_hsa052150.43777208
112Synaptic vesicle cycle_Homo sapiens_hsa047210.43281843
113Antigen processing and presentation_Homo sapiens_hsa046120.41617192
114Chronic myeloid leukemia_Homo sapiens_hsa052200.39330556
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35677377
116Melanoma_Homo sapiens_hsa052180.35220727
117Tuberculosis_Homo sapiens_hsa051520.33695776
118Non-small cell lung cancer_Homo sapiens_hsa052230.33655244
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.33000122
120Hepatitis B_Homo sapiens_hsa051610.32649382
121HTLV-I infection_Homo sapiens_hsa051660.31709764
122Measles_Homo sapiens_hsa051620.31640973
123Legionellosis_Homo sapiens_hsa051340.29717589
124Cardiac muscle contraction_Homo sapiens_hsa042600.28754766
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28592694
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27756043
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.26868905
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22431454
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19382137
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15880329
131Acute myeloid leukemia_Homo sapiens_hsa052210.14901084
132Peroxisome_Homo sapiens_hsa041460.12709234
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.11748841
134beta-Alanine metabolism_Homo sapiens_hsa004100.11026712
135Fatty acid degradation_Homo sapiens_hsa000710.09943524
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.09277942
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06619231
138Arginine and proline metabolism_Homo sapiens_hsa003300.04507197
139Platelet activation_Homo sapiens_hsa046110.04311720
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.03705483
141Galactose metabolism_Homo sapiens_hsa000520.03285833
142Influenza A_Homo sapiens_hsa051640.02124577
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.01446197
144AMPK signaling pathway_Homo sapiens_hsa041520.00791148
145Propanoate metabolism_Homo sapiens_hsa00640-0.0355018
146Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0137999
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770-0.0021147

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