EPN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.82188081
2central nervous system myelination (GO:0022010)5.82188081
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.96101511
4neuron cell-cell adhesion (GO:0007158)4.68508078
5locomotory exploration behavior (GO:0035641)4.28250861
6myelination (GO:0042552)3.85200178
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.84799243
8axon ensheathment (GO:0008366)3.81008224
9ensheathment of neurons (GO:0007272)3.81008224
10sodium ion export (GO:0071436)3.73877887
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71957977
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.60581287
13vocalization behavior (GO:0071625)3.57163197
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.50602218
15presynaptic membrane organization (GO:0097090)3.47252879
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45475672
17presynaptic membrane assembly (GO:0097105)3.43224148
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.42353573
19L-amino acid import (GO:0043092)3.37839369
20negative regulation of protein localization to cell surface (GO:2000009)3.37734568
21neuronal action potential propagation (GO:0019227)3.37681789
22neuron recognition (GO:0008038)3.36059492
23negative regulation of neurotransmitter transport (GO:0051589)3.34095671
24cell communication by electrical coupling (GO:0010644)3.29422624
25cerebellar granule cell differentiation (GO:0021707)3.29125462
26long-chain fatty acid biosynthetic process (GO:0042759)3.28372837
27synaptic vesicle maturation (GO:0016188)3.27927878
28dendritic spine morphogenesis (GO:0060997)3.27302956
29layer formation in cerebral cortex (GO:0021819)3.20191582
30synaptic vesicle exocytosis (GO:0016079)3.16353836
31axonal fasciculation (GO:0007413)3.15917968
32glutamate receptor signaling pathway (GO:0007215)3.15178375
33exploration behavior (GO:0035640)3.13365883
34transmission of nerve impulse (GO:0019226)3.12965941
35synaptic transmission, glutamatergic (GO:0035249)3.11231361
36positive regulation of synapse maturation (GO:0090129)3.08684991
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07354713
38negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.06130870
39protein localization to synapse (GO:0035418)3.06108305
40potassium ion homeostasis (GO:0055075)3.04721833
41regulation of synaptic vesicle exocytosis (GO:2000300)3.04432208
42regulation of glutamate receptor signaling pathway (GO:1900449)3.03852925
43regulation of neuronal synaptic plasticity (GO:0048168)3.03584406
44neurotransmitter secretion (GO:0007269)3.03063801
45glutamate secretion (GO:0014047)3.02850637
46potassium ion import (GO:0010107)3.02842953
47glycerophospholipid catabolic process (GO:0046475)3.01543168
48peripheral nervous system axon ensheathment (GO:0032292)3.00414011
49myelination in peripheral nervous system (GO:0022011)3.00414011
50regulation of dendritic spine morphogenesis (GO:0061001)2.99918959
51negative regulation of neurotransmitter secretion (GO:0046929)2.98530821
52neuron-neuron synaptic transmission (GO:0007270)2.95259828
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94592574
54adult walking behavior (GO:0007628)2.93351463
55apical protein localization (GO:0045176)2.91980084
56dendrite morphogenesis (GO:0048813)2.89618308
57amino acid import (GO:0043090)2.88998356
58eye photoreceptor cell differentiation (GO:0001754)2.87777977
59photoreceptor cell differentiation (GO:0046530)2.87777977
60peptidyl-tyrosine autophosphorylation (GO:0038083)2.84134524
61regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83132066
62cell communication involved in cardiac conduction (GO:0086065)2.81972344
63postsynaptic membrane organization (GO:0001941)2.80442286
64neurotransmitter-gated ion channel clustering (GO:0072578)2.80126179
65cerebral cortex radially oriented cell migration (GO:0021799)2.79711250
66fatty acid elongation (GO:0030497)2.78461889
67regulation of synaptic vesicle transport (GO:1902803)2.78330786
68long-term synaptic potentiation (GO:0060291)2.76808463
69positive regulation of neurological system process (GO:0031646)2.76373898
70oligodendrocyte differentiation (GO:0048709)2.75375465
71asymmetric protein localization (GO:0008105)2.73785357
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72690810
73regulation of synapse maturation (GO:0090128)2.67731858
74cellular sodium ion homeostasis (GO:0006883)2.67707526
75neuronal ion channel clustering (GO:0045161)2.66971419
76neuromuscular process controlling balance (GO:0050885)2.65714809
77negative regulation of axon extension (GO:0030517)2.65528914
78establishment of mitochondrion localization (GO:0051654)2.65491247
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.63997333
80dendritic spine organization (GO:0097061)2.63315311
81gamma-aminobutyric acid signaling pathway (GO:0007214)2.62528871
82negative regulation of axonogenesis (GO:0050771)2.61675415
83regulation of synaptic transmission, glutamatergic (GO:0051966)2.60080324
84righting reflex (GO:0060013)2.59862093
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.59145265
86cerebellar Purkinje cell layer development (GO:0021680)2.58306972
87innervation (GO:0060384)2.56648543
88membrane assembly (GO:0071709)2.55844898
89regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55664641
90regulation of synaptic plasticity (GO:0048167)2.55257151
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.54973249
92regulation of collateral sprouting (GO:0048670)2.54935784
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54410070
94membrane hyperpolarization (GO:0060081)2.54405703
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53876078
96long-term memory (GO:0007616)2.53607869
97positive regulation of synapse assembly (GO:0051965)2.53020180
98response to redox state (GO:0051775)2.52134178
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.51636279
100glycine transport (GO:0015816)2.51503775
101auditory behavior (GO:0031223)2.51202488
102positive regulation of membrane potential (GO:0045838)2.50167541
103astrocyte development (GO:0014002)2.48425290
104regulation of synapse structural plasticity (GO:0051823)2.47064562
105neuron remodeling (GO:0016322)2.46494605
106negative regulation of hormone metabolic process (GO:0032351)2.45931267
107negative regulation of hormone biosynthetic process (GO:0032353)2.45931267
108regulation of dendritic spine development (GO:0060998)2.45931258
109myelin maintenance (GO:0043217)2.45707842
110neurotransmitter transport (GO:0006836)2.45573504
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.44635428
112cellular potassium ion homeostasis (GO:0030007)2.44623752
113neurotransmitter uptake (GO:0001504)2.44060975
114response to auditory stimulus (GO:0010996)2.43935957
115regulation of postsynaptic membrane potential (GO:0060078)2.43341963
116cell migration in hindbrain (GO:0021535)2.42816031
117mechanosensory behavior (GO:0007638)2.42302200
118positive regulation of dendritic spine development (GO:0060999)2.42012803
119gamma-aminobutyric acid transport (GO:0015812)2.41634860
120synapse organization (GO:0050808)2.41577665
121synaptic vesicle endocytosis (GO:0048488)2.41076254
122positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.40741403
123regulation of cell communication by electrical coupling (GO:0010649)2.39596278
124dermatan sulfate biosynthetic process (GO:0030208)2.37910071
125regulation of neurotransmitter levels (GO:0001505)2.35979474
126positive regulation of dendrite development (GO:1900006)2.32753463
127synapse assembly (GO:0007416)2.32063474
128regulation of axon extension involved in axon guidance (GO:0048841)2.29686425
129regulation of voltage-gated calcium channel activity (GO:1901385)2.27938719
130regulation of respiratory system process (GO:0044065)2.27485442
131negative regulation of catenin import into nucleus (GO:0035414)2.25484063
132acidic amino acid transport (GO:0015800)2.24854445
133regulation of cardiac muscle cell contraction (GO:0086004)2.24825771
134dermatan sulfate metabolic process (GO:0030205)2.22771047
135negative regulation of cytosolic calcium ion concentration (GO:0051481)2.22096901
136regulation of synapse organization (GO:0050807)2.21447748
137regulation of synapse assembly (GO:0051963)2.19760647
138axon extension (GO:0048675)2.17758225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.45481879
2GBX2_23144817_ChIP-Seq_PC3_Human3.16594767
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61978151
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61946800
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55937590
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48210014
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48210014
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.28320344
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19597580
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17919218
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15508681
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14949831
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13681758
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.11566537
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06463302
16* AR_21572438_ChIP-Seq_LNCaP_Human2.04072222
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.03844488
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01886839
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.95318780
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90796740
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86096059
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.84492966
23DROSHA_22980978_ChIP-Seq_HELA_Human1.76518404
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.75871877
25REST_21632747_ChIP-Seq_MESCs_Mouse1.73480667
26* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73466140
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.72620053
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69265188
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65012388
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58371969
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.53547293
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53510683
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52169882
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50550223
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49654690
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49369063
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47366641
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46267368
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45955159
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43045656
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.42064183
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42038347
43* REST_18959480_ChIP-ChIP_MESCs_Mouse1.38859861
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37770725
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36014125
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.35854641
47TAF15_26573619_Chip-Seq_HEK293_Human1.34635702
48* STAT3_23295773_ChIP-Seq_U87_Human1.34090440
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32420447
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.32184489
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31185088
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.30647096
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29550390
54KDM2B_26808549_Chip-Seq_K562_Human1.29531424
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27219394
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27203301
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26238230
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26015149
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.25668065
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24565027
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24206109
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24200580
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24117943
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23502219
65RNF2_27304074_Chip-Seq_NSC_Mouse1.22797950
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21594373
67P300_19829295_ChIP-Seq_ESCs_Human1.21004921
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20992398
69* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20332723
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19679499
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.19449677
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.19313406
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.19190650
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17400042
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.16970183
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16949184
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.16378084
78ZNF274_21170338_ChIP-Seq_K562_Hela1.16225220
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15987740
80VDR_22108803_ChIP-Seq_LS180_Human1.15608902
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.15318884
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.13195775
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11533332
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11526085
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.10874630
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10862312
87CTCF_27219007_Chip-Seq_Bcells_Human1.10373687
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10113884
89AHR_22903824_ChIP-Seq_MCF-7_Human1.09876507
90ER_23166858_ChIP-Seq_MCF-7_Human1.08130398
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07949837
92* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07695927
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06699287
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06607941
95* FUS_26573619_Chip-Seq_HEK293_Human1.06171506
96TP53_16413492_ChIP-PET_HCT116_Human1.05683143
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05344774
98* AR_25329375_ChIP-Seq_VCAP_Human1.05111766
99* TP53_23651856_ChIP-Seq_MEFs_Mouse1.04911289
100* TCF4_23295773_ChIP-Seq_U87_Human1.04273780
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.02984770
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02269525
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.02087741
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01769174
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01403671
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01112087
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00993984
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00993984
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00825352
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00191097
111* AR_19668381_ChIP-Seq_PC3_Human0.99448020
112* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98366866
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97477249
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96074972
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.95846512
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95366984
117LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94952284
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94704436
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.93876870
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93484529
121* RUNX2_22187159_ChIP-Seq_PCA_Human0.92927208
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92726810
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.92351591
124TP63_17297297_ChIP-ChIP_HaCaT_Human0.91251800
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90357607
126* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88705053
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88647491
128RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87038103
129* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87024231
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86031559
131SOX9_26525672_Chip-Seq_HEART_Mouse0.84962119
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82175633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.40978158
2MP0003880_abnormal_central_pattern4.07136097
3MP0004270_analgesia3.23192502
4MP0003635_abnormal_synaptic_transmissio2.90297154
5MP0005423_abnormal_somatic_nervous2.40692429
6MP0001486_abnormal_startle_reflex2.35875254
7MP0002063_abnormal_learning/memory/cond2.33662788
8MP0004885_abnormal_endolymph2.30105189
9MP0002064_seizures2.29225770
10MP0002272_abnormal_nervous_system2.25158730
11MP0009745_abnormal_behavioral_response2.23547436
12MP0000920_abnormal_myelination2.23392319
13MP0000778_abnormal_nervous_system2.18618604
14MP0003329_amyloid_beta_deposits2.11105356
15MP0002734_abnormal_mechanical_nocicepti2.06971460
16MP0001529_abnormal_vocalization2.01605769
17MP0009046_muscle_twitch2.01280204
18MP0002572_abnormal_emotion/affect_behav2.00094310
19MP0002822_catalepsy1.88707865
20MP0003950_abnormal_plasma_membrane1.86662271
21MP0001968_abnormal_touch/_nociception1.76672228
22MP0002653_abnormal_ependyma_morphology1.70015935
23MP0000566_synostosis1.69544849
24MP0004742_abnormal_vestibular_system1.68707911
25MP0001440_abnormal_grooming_behavior1.61564906
26MP0000955_abnormal_spinal_cord1.57688337
27MP0001905_abnormal_dopamine_level1.55087908
28MP0002067_abnormal_sensory_capabilities1.54405109
29MP0002184_abnormal_innervation1.53585526
30MP0002736_abnormal_nociception_after1.52954133
31MP0005171_absent_coat_pigmentation1.52904997
32MP0002733_abnormal_thermal_nociception1.52589919
33MP0001970_abnormal_pain_threshold1.48799210
34MP0004145_abnormal_muscle_electrophysio1.48055056
35MP0003634_abnormal_glial_cell1.44304223
36MP0002882_abnormal_neuron_morphology1.44134065
37MP0003632_abnormal_nervous_system1.42086798
38MP0003136_yellow_coat_color1.39410320
39MP0005646_abnormal_pituitary_gland1.37396408
40MP0005386_behavior/neurological_phenoty1.34726917
41MP0004924_abnormal_behavior1.34726917
42MP0008569_lethality_at_weaning1.34701462
43MP0005623_abnormal_meninges_morphology1.34556721
44MP0003705_abnormal_hypodermis_morpholog1.34250777
45MP0003690_abnormal_glial_cell1.33797360
46MP0004858_abnormal_nervous_system1.29061019
47MP0002735_abnormal_chemical_nociception1.28789858
48MP0001485_abnormal_pinna_reflex1.27999366
49MP0002066_abnormal_motor_capabilities/c1.26850889
50MP0010030_abnormal_orbit_morphology1.25357294
51MP0000462_abnormal_digestive_system1.24076528
52MP0002102_abnormal_ear_morphology1.24059406
53MP0004142_abnormal_muscle_tone1.22873004
54MP0002557_abnormal_social/conspecific_i1.22488769
55MP0002152_abnormal_brain_morphology1.18766755
56MP0001501_abnormal_sleep_pattern1.18467136
57MP0001502_abnormal_circadian_rhythm1.16366924
58MP0004185_abnormal_adipocyte_glucose1.14609226
59MP0001299_abnormal_eye_distance/1.14516581
60MP0004133_heterotaxia1.12985896
61MP0003631_nervous_system_phenotype1.11147283
62MP0003879_abnormal_hair_cell1.11073553
63MP0000049_abnormal_middle_ear1.09758330
64MP0002229_neurodegeneration1.09492956
65MP0002752_abnormal_somatic_nervous1.06983888
66MP0005551_abnormal_eye_electrophysiolog1.04736680
67MP0004272_abnormal_basement_membrane1.04149729
68MP0003937_abnormal_limbs/digits/tail_de1.03540457
69MP0001177_atelectasis1.03349103
70MP0001958_emphysema1.02569481
71MP0002249_abnormal_larynx_morphology1.02008182
72MP0001963_abnormal_hearing_physiology1.00995182
73MP0004811_abnormal_neuron_physiology1.00811182
74MP0005503_abnormal_tendon_morphology0.99443689
75MP0003861_abnormal_nervous_system0.98864831
76MP0003942_abnormal_urinary_system0.98623561
77MP0000534_abnormal_ureter_morphology0.98086865
78MP0001984_abnormal_olfaction0.97961264
79MP0005451_abnormal_body_composition0.96580387
80MP0000631_abnormal_neuroendocrine_gland0.96103136
81MP0010678_abnormal_skin_adnexa0.95792988
82MP0009780_abnormal_chondrocyte_physiolo0.92956546
83MP0000751_myopathy0.92750447
84MP0006276_abnormal_autonomic_nervous0.91447798
85MP0010368_abnormal_lymphatic_system0.90615460
86MP0003122_maternal_imprinting0.90366286
87MP0009250_abnormal_appendicular_skeleto0.89596141
88MP0003941_abnormal_skin_development0.88222334
89MP0003633_abnormal_nervous_system0.88144297
90MP0005275_abnormal_skin_tensile0.87676804
91MP0003938_abnormal_ear_development0.86601196
92MP0005409_darkened_coat_color0.86404605
93MP0005645_abnormal_hypothalamus_physiol0.83223876
94MP0003787_abnormal_imprinting0.83049576
95MP0002116_abnormal_craniofacial_bone0.82705857
96MP0004215_abnormal_myocardial_fiber0.81355699
97MP0002089_abnormal_postnatal_growth/wei0.80381569
98MP0006072_abnormal_retinal_apoptosis0.79867278
99MP0004134_abnormal_chest_morphology0.79593698
100MP0000428_abnormal_craniofacial_morphol0.79475680
101MP0000026_abnormal_inner_ear0.79037748
102MP0004085_abnormal_heartbeat0.78924653
103MP0005410_abnormal_fertilization0.76954352
104MP0002909_abnormal_adrenal_gland0.76936059
105MP0008438_abnormal_cutaneous_collagen0.76317596
106MP0000579_abnormal_nail_morphology0.75514099
107MP0003755_abnormal_palate_morphology0.75162825
108MP0005257_abnormal_intraocular_pressure0.74713762
109MP0000383_abnormal_hair_follicle0.74541588
110MP0000013_abnormal_adipose_tissue0.74105807
111MP0003385_abnormal_body_wall0.73531883
112MP0003137_abnormal_impulse_conducting0.73353207
113MP0009384_cardiac_valve_regurgitation0.73290115
114MP0000749_muscle_degeneration0.73103193
115MP0009379_abnormal_foot_pigmentation0.73080343
116MP0001346_abnormal_lacrimal_gland0.70992582
117MP0000762_abnormal_tongue_morphology0.70462589
118MP0000003_abnormal_adipose_tissue0.69619722
119MP0002108_abnormal_muscle_morphology0.69030211
120MP0003123_paternal_imprinting0.69020812
121MP0004036_abnormal_muscle_relaxation0.68971512
122MP0005195_abnormal_posterior_eye0.67005796
123MP0000467_abnormal_esophagus_morphology0.66127355
124MP0003718_maternal_effect0.65721418
125MP0008260_abnormal_autophagy0.65408655
126MP0002233_abnormal_nose_morphology0.64192072

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.52865906
2Focal motor seizures (HP:0011153)4.22560269
3Neurofibrillary tangles (HP:0002185)4.15745770
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.07376049
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.07376049
6Abnormality of the corticospinal tract (HP:0002492)3.66846102
7Cerebral inclusion bodies (HP:0100314)3.42928916
8Termporal pattern (HP:0011008)3.22797604
9Insidious onset (HP:0003587)3.22797604
10Peripheral hypomyelination (HP:0007182)3.22341369
11Action tremor (HP:0002345)3.19399372
12Focal seizures (HP:0007359)3.13739849
13Supranuclear gaze palsy (HP:0000605)3.06354420
14Ankle clonus (HP:0011448)3.01332620
15Dysmetria (HP:0001310)2.97619544
16Shallow orbits (HP:0000586)2.80281165
17Aplasia involving bones of the upper limbs (HP:0009823)2.72809665
18Aplasia of the phalanges of the hand (HP:0009802)2.72809665
19Aplasia involving bones of the extremities (HP:0009825)2.72809665
20Intention tremor (HP:0002080)2.71234366
21Spastic gait (HP:0002064)2.65687932
22Atonic seizures (HP:0010819)2.65162436
23Onion bulb formation (HP:0003383)2.62797780
24Bronchomalacia (HP:0002780)2.59970365
25Progressive cerebellar ataxia (HP:0002073)2.58886473
26Coronal craniosynostosis (HP:0004440)2.58412023
27Broad-based gait (HP:0002136)2.43813530
28Epileptic encephalopathy (HP:0200134)2.40348724
29Dysdiadochokinesis (HP:0002075)2.35920729
30Lower limb muscle weakness (HP:0007340)2.33622100
31Abnormal auditory evoked potentials (HP:0006958)2.32588185
32Cerebral hypomyelination (HP:0006808)2.30285659
33Scanning speech (HP:0002168)2.29288322
34Megalencephaly (HP:0001355)2.28023749
35Sleep apnea (HP:0010535)2.26836770
36Thickened helices (HP:0000391)2.24276353
37Insomnia (HP:0100785)2.24184890
38Retinal dysplasia (HP:0007973)2.23917207
39Sensory axonal neuropathy (HP:0003390)2.22251783
40Visual hallucinations (HP:0002367)2.21425859
41Absent speech (HP:0001344)2.20197625
42Oligodactyly (hands) (HP:0001180)2.19958244
43Morphological abnormality of the inner ear (HP:0011390)2.19547608
44Turricephaly (HP:0000262)2.17220408
45Fetal akinesia sequence (HP:0001989)2.14217200
46Bundle branch block (HP:0011710)2.11921569
47Hyperacusis (HP:0010780)2.10220699
48Urinary bladder sphincter dysfunction (HP:0002839)2.08503094
49Gaze-evoked nystagmus (HP:0000640)2.04048258
50Urinary urgency (HP:0000012)2.03947525
51Alacrima (HP:0000522)2.02753806
52Hammertoe (HP:0001765)2.01815341
53Excessive salivation (HP:0003781)2.00370418
54Drooling (HP:0002307)2.00370418
55Broad metatarsal (HP:0001783)1.99390875
56Hyperventilation (HP:0002883)1.98368210
57Cutaneous finger syndactyly (HP:0010554)1.97304674
58Absent septum pellucidum (HP:0001331)1.93981594
59Impaired vibration sensation in the lower limbs (HP:0002166)1.93897968
60Generalized tonic-clonic seizures (HP:0002069)1.92791368
61Humeroradial synostosis (HP:0003041)1.92610685
62Synostosis involving the elbow (HP:0003938)1.92610685
63Hypoplastic pelvis (HP:0008839)1.90407376
64Diplopia (HP:0000651)1.90345550
65Abnormality of binocular vision (HP:0011514)1.90345550
66Abnormality of the aortic arch (HP:0012303)1.89942467
67Hemiparesis (HP:0001269)1.86339145
68Split foot (HP:0001839)1.85101331
69Adrenal hypoplasia (HP:0000835)1.83929874
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83015645
71Male infertility (HP:0003251)1.81582496
72Anosmia (HP:0000458)1.81055753
73Febrile seizures (HP:0002373)1.80319550
74Ulnar claw (HP:0001178)1.79793994
75Clonus (HP:0002169)1.78545403
76Pheochromocytoma (HP:0002666)1.78432433
77Segmental peripheral demyelination/remyelination (HP:0003481)1.77490217
78Overriding aorta (HP:0002623)1.77286574
79Cutaneous syndactyly (HP:0012725)1.74167766
80Epileptiform EEG discharges (HP:0011182)1.73885163
81Hypoplasia of the iris (HP:0007676)1.73692860
82Aqueductal stenosis (HP:0002410)1.73130072
83Abnormal eating behavior (HP:0100738)1.72892577
84Dialeptic seizures (HP:0011146)1.72795690
85Esophageal atresia (HP:0002032)1.72332124
86Abnormality of the lower motor neuron (HP:0002366)1.71571929
87Abnormality of the labia minora (HP:0012880)1.71552101
88Elfin facies (HP:0004428)1.71173702
89Chin dimple (HP:0010751)1.70692988
90Mutism (HP:0002300)1.70254444
91Laryngomalacia (HP:0001601)1.70024951
92Absence seizures (HP:0002121)1.68325479
93Generalized myoclonic seizures (HP:0002123)1.67151943
94CNS hypomyelination (HP:0003429)1.65719718
95Amblyopia (HP:0000646)1.65271675
96Hyporeflexia of lower limbs (HP:0002600)1.65180436
97Morphological abnormality of the pyramidal tract (HP:0002062)1.65039411
98Steppage gait (HP:0003376)1.64764333
99Renovascular hypertension (HP:0100817)1.64145307
100Neonatal short-limb short stature (HP:0008921)1.63780564
101Truncal ataxia (HP:0002078)1.63674515
102Bladder diverticulum (HP:0000015)1.63307664
103Abnormality of the middle phalanges of the toes (HP:0010183)1.63237443
104Obstructive sleep apnea (HP:0002870)1.62846374
105Limb dystonia (HP:0002451)1.62765267
106EEG with generalized epileptiform discharges (HP:0011198)1.62511964
107Decreased lacrimation (HP:0000633)1.62023207
108Arterial tortuosity (HP:0005116)1.61902746
109Abnormality of the septum pellucidum (HP:0007375)1.61375055
110Muscle fiber splitting (HP:0003555)1.60830487
111Increased circulating renin level (HP:0000848)1.60386658
112Distal upper limb amyotrophy (HP:0007149)1.59466940
113Upper limb amyotrophy (HP:0009129)1.59466940
114Torticollis (HP:0000473)1.58837998
115Decreased motor nerve conduction velocity (HP:0003431)1.58701821
116Postural instability (HP:0002172)1.58483228
117Bowel incontinence (HP:0002607)1.57589181
118Hand muscle atrophy (HP:0009130)1.57351402
119Anxiety (HP:0000739)1.56848642
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.56620290
121Anomalous pulmonary venous return (HP:0010772)1.56131055
122Tracheomalacia (HP:0002779)1.55999716
123Relative macrocephaly (HP:0004482)1.55835638
124Septo-optic dysplasia (HP:0100842)1.55060411
125Distal sensory impairment (HP:0002936)1.54180629
126Hypsarrhythmia (HP:0002521)1.53739750
127Akinesia (HP:0002304)1.53685878
128Parakeratosis (HP:0001036)1.53483273
129Bowel diverticulosis (HP:0005222)1.53152371
130Cupped ear (HP:0000378)1.52545110
131Depression (HP:0000716)1.52126576
132Rapidly progressive (HP:0003678)1.52091507
133Poor eye contact (HP:0000817)1.51827701
134Hypoventilation (HP:0002791)1.49741913
135Heart block (HP:0012722)1.49528748
136Abnormal atrioventricular conduction (HP:0005150)1.48435003
137Bell-shaped thorax (HP:0001591)1.48104194
138Vertebral arch anomaly (HP:0008438)1.48038127
139Neoplasm of the heart (HP:0100544)1.47336081
140Partial duplication of thumb phalanx (HP:0009944)1.46690092
141Syncope (HP:0001279)1.45115286
142Abnormality of the diencephalon (HP:0010662)1.45034255
143Gait imbalance (HP:0002141)1.44586044
144Genetic anticipation (HP:0003743)1.44084196
145Protrusio acetabuli (HP:0003179)1.42516880
146Arnold-Chiari malformation (HP:0002308)1.42464592
147Annular pancreas (HP:0001734)1.41667527
148Prolonged QT interval (HP:0001657)1.39559073
149Flat cornea (HP:0007720)1.39497042
150Abnormality of the pulmonary veins (HP:0011718)1.39127020
151Impaired social interactions (HP:0000735)1.37517078
152Abnormal social behavior (HP:0012433)1.37517078
153Stridor (HP:0010307)1.37396546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.24579060
2KSR23.21745560
3STK392.86368336
4MAP3K92.75559179
5NTRK32.55447883
6PAK62.46671941
7RIPK12.32264355
8OXSR12.20206625
9LATS22.17470896
10PRKD32.15815540
11TYRO32.15317922
12CASK2.13703354
13MAP3K42.09655835
14MARK12.08190273
15PNCK1.79722335
16NTRK11.72349855
17PRPF4B1.72278608
18MAPKAPK51.70122214
19KSR11.63178489
20MAP3K21.63072807
21LATS11.58446534
22NTRK21.53068314
23ERBB41.49380788
24BCR1.49041538
25MAPK131.34583836
26EPHA21.26795723
27MET1.24884502
28LMTK21.21662483
29PKN11.20860675
30EEF2K1.19644532
31MAP2K71.19306720
32PAK31.18840052
33EPHB11.18782987
34MINK11.16301729
35DMPK1.14059355
36DYRK21.12572848
37CDK51.11580651
38ARAF1.11539653
39MAP3K61.11110382
40SGK2231.11103837
41SGK4941.11103837
42WNK11.10994581
43PHKG11.08325039
44PHKG21.08325039
45MUSK1.07644545
46FGFR21.06955853
47UHMK11.06198212
48CAMK11.06153553
49WNK41.05963624
50TNIK1.02799651
51SGK21.01732328
52MARK21.01360136
53MAPK151.00439347
54STK380.99512952
55CSNK1G20.98846229
56CAMK2A0.98661282
57RAF10.98407483
58TAOK10.98150859
59ROCK20.98115095
60MAP2K40.96213469
61MAP3K130.95487990
62CAMK2B0.93354136
63RET0.92219132
64CSNK1A1L0.92211403
65TRIB30.90224489
66CAMKK10.88856629
67NEK60.88398935
68PIK3CA0.87636143
69CSNK1G30.87044934
70SGK30.86258079
71LIMK10.85749092
72DAPK20.85059578
73PLK20.84274368
74EPHB20.82903377
75FGR0.82716650
76STK38L0.81669317
77CDK150.80494465
78CAMK2D0.79326633
79CDK140.79203691
80CDK180.78188440
81CAMK40.77482556
82SIK10.77046933
83PRKCH0.75026771
84MAP3K70.74957347
85PINK10.72678278
86PDGFRA0.71701138
87CDK190.71387509
88MOS0.71150591
89TIE10.70673561
90ICK0.70665188
91CSNK1G10.70241456
92BMPR20.69348800
93PDGFRB0.68267432
94PTK2B0.67790165
95CDK11A0.67163829
96STK110.64619307
97BRAF0.63677607
98DDR20.63620156
99CAMK1G0.63458082
100MTOR0.62965735
101AKT30.61715935
102MAP2K10.60371087
103GRK50.60209272
104PRKD20.59454856
105DYRK1A0.57518363
106CAMK2G0.56185197
107FER0.54959879
108PRKCZ0.54763415
109MAPK120.54172337
110PAK20.53462545
111BRSK10.53053493
112FES0.52512983
113ERBB20.51278360
114RPS6KA20.50678624
115FGFR10.50440865
116MAP3K10.49031140
117PRKCE0.48972011
118MYLK0.48617076
119* RPS6KA30.48017339
120ROCK10.47222522
121TTN0.46211846
122PRKD10.45119171
123MST1R0.44647245
124SIK20.44334291
125MELK0.43800640
126PRKCG0.43681255
127SGK10.43534159
128MAPK100.43078200
129PRKAA10.42858024
130PTK20.42528184
131CAMK1D0.42517771

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.64410395
2Glutamatergic synapse_Homo sapiens_hsa047242.41383573
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21922578
4GABAergic synapse_Homo sapiens_hsa047272.12882590
5Circadian entrainment_Homo sapiens_hsa047132.06902374
6Long-term depression_Homo sapiens_hsa047302.03363364
7Long-term potentiation_Homo sapiens_hsa047202.00523497
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91916843
9Synaptic vesicle cycle_Homo sapiens_hsa047211.90654600
10Axon guidance_Homo sapiens_hsa043601.88903214
11Morphine addiction_Homo sapiens_hsa050321.85800176
12Salivary secretion_Homo sapiens_hsa049701.79364195
13Serotonergic synapse_Homo sapiens_hsa047261.78762936
14Dopaminergic synapse_Homo sapiens_hsa047281.74064599
15Amphetamine addiction_Homo sapiens_hsa050311.72597325
16Olfactory transduction_Homo sapiens_hsa047401.70556472
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69274282
18Cholinergic synapse_Homo sapiens_hsa047251.58628915
19Dorso-ventral axis formation_Homo sapiens_hsa043201.55767631
20Gastric acid secretion_Homo sapiens_hsa049711.54855250
21Vitamin B6 metabolism_Homo sapiens_hsa007501.54574980
22Ether lipid metabolism_Homo sapiens_hsa005651.54398289
23GnRH signaling pathway_Homo sapiens_hsa049121.52513476
24Gap junction_Homo sapiens_hsa045401.51287373
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46256157
26Oxytocin signaling pathway_Homo sapiens_hsa049211.45206432
27Taste transduction_Homo sapiens_hsa047421.43736259
28Cocaine addiction_Homo sapiens_hsa050301.42083340
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39415792
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38107717
31Renin secretion_Homo sapiens_hsa049241.34376808
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33575684
33Renal cell carcinoma_Homo sapiens_hsa052111.32058795
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30251336
35Insulin secretion_Homo sapiens_hsa049111.29205201
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.21187727
37ErbB signaling pathway_Homo sapiens_hsa040121.20843020
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19107513
39Ovarian steroidogenesis_Homo sapiens_hsa049131.18843190
40Choline metabolism in cancer_Homo sapiens_hsa052311.18745602
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.18291100
42cAMP signaling pathway_Homo sapiens_hsa040241.16662800
43Tight junction_Homo sapiens_hsa045301.13353169
44Glioma_Homo sapiens_hsa052141.12446075
45Calcium signaling pathway_Homo sapiens_hsa040201.11374066
46Steroid biosynthesis_Homo sapiens_hsa001001.09264380
47Estrogen signaling pathway_Homo sapiens_hsa049151.09214845
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08660709
49Oocyte meiosis_Homo sapiens_hsa041141.08003169
50Melanogenesis_Homo sapiens_hsa049161.06795550
51Bile secretion_Homo sapiens_hsa049761.05777505
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00449123
53Ras signaling pathway_Homo sapiens_hsa040140.99169516
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98026385
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97743259
56Hedgehog signaling pathway_Homo sapiens_hsa043400.97589929
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97402457
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97249310
59Dilated cardiomyopathy_Homo sapiens_hsa054140.95383849
60Fatty acid elongation_Homo sapiens_hsa000620.94462488
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91768260
62Hippo signaling pathway_Homo sapiens_hsa043900.90450983
63Cardiac muscle contraction_Homo sapiens_hsa042600.89095027
64Histidine metabolism_Homo sapiens_hsa003400.88915952
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87688807
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87314798
67Sphingolipid metabolism_Homo sapiens_hsa006000.86690426
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.86497023
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85988591
70Adherens junction_Homo sapiens_hsa045200.84821776
71Phototransduction_Homo sapiens_hsa047440.83396539
72Arginine and proline metabolism_Homo sapiens_hsa003300.81235567
73Collecting duct acid secretion_Homo sapiens_hsa049660.80227004
74Nitrogen metabolism_Homo sapiens_hsa009100.79759867
75Circadian rhythm_Homo sapiens_hsa047100.79370777
76beta-Alanine metabolism_Homo sapiens_hsa004100.77753985
77MAPK signaling pathway_Homo sapiens_hsa040100.76616863
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76052615
79Wnt signaling pathway_Homo sapiens_hsa043100.75322089
80VEGF signaling pathway_Homo sapiens_hsa043700.74465576
81Pancreatic secretion_Homo sapiens_hsa049720.74413147
82Rap1 signaling pathway_Homo sapiens_hsa040150.74024454
83Notch signaling pathway_Homo sapiens_hsa043300.72968017
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.71924594
85Glucagon signaling pathway_Homo sapiens_hsa049220.70587271
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69575289
87Type II diabetes mellitus_Homo sapiens_hsa049300.68580413
88AMPK signaling pathway_Homo sapiens_hsa041520.66720266
89Vibrio cholerae infection_Homo sapiens_hsa051100.66016852
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65838092
91Mineral absorption_Homo sapiens_hsa049780.65790409
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65392804
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64968149
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64769372
95TGF-beta signaling pathway_Homo sapiens_hsa043500.63457467
96Protein digestion and absorption_Homo sapiens_hsa049740.61662827
97* Endocytosis_Homo sapiens_hsa041440.61354884
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61129484
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60883066
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57902093
101Linoleic acid metabolism_Homo sapiens_hsa005910.57815490
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57510784
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56963497
104Lysine degradation_Homo sapiens_hsa003100.56800448
105Basal cell carcinoma_Homo sapiens_hsa052170.55146332
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55125408
107Prion diseases_Homo sapiens_hsa050200.54531327
108Melanoma_Homo sapiens_hsa052180.54476522
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53694855
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.52908662
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52845151
112Focal adhesion_Homo sapiens_hsa045100.51665149
113Insulin signaling pathway_Homo sapiens_hsa049100.50997208
114Thyroid hormone synthesis_Homo sapiens_hsa049180.50357760
115ECM-receptor interaction_Homo sapiens_hsa045120.50057019
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49939982
117Alcoholism_Homo sapiens_hsa050340.49884076
118MicroRNAs in cancer_Homo sapiens_hsa052060.49220040
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48311403
120Proteoglycans in cancer_Homo sapiens_hsa052050.47016551
121Inositol phosphate metabolism_Homo sapiens_hsa005620.46914183
122Endometrial cancer_Homo sapiens_hsa052130.45722077
123Colorectal cancer_Homo sapiens_hsa052100.45425504
124Fatty acid biosynthesis_Homo sapiens_hsa000610.43093197

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