EPM2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)8.02867998
2response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.28735544
3actin filament-based movement (GO:0030048)5.72114483
4response to inactivity (GO:0014854)5.58163560
5response to muscle activity (GO:0014850)5.37350577
6regulation of actin filament-based movement (GO:1903115)5.08654033
7skeletal muscle fiber development (GO:0048741)4.97689719
8cardiac myofibril assembly (GO:0055003)4.87488567
9myotube cell development (GO:0014904)4.79910695
10muscle contraction (GO:0006936)4.60796019
11neuronal action potential propagation (GO:0019227)4.57572264
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.50260302
13sarcoplasmic reticulum calcium ion transport (GO:0070296)4.49827335
14cardiac muscle hypertrophy (GO:0003300)4.34858314
15skeletal muscle adaptation (GO:0043501)4.27499324
16muscle fiber development (GO:0048747)4.25159559
17striated muscle hypertrophy (GO:0014897)4.18795934
18muscle system process (GO:0003012)4.16480605
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.16129699
20actomyosin structure organization (GO:0031032)4.14637754
21synaptic vesicle maturation (GO:0016188)4.05947304
22regulation of striated muscle contraction (GO:0006942)3.89885131
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89603501
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88670530
25locomotory exploration behavior (GO:0035641)3.82698937
26regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.80867751
27* glucan biosynthetic process (GO:0009250)3.79347903
28* glycogen biosynthetic process (GO:0005978)3.79347903
29synaptic vesicle exocytosis (GO:0016079)3.77606222
30vocalization behavior (GO:0071625)3.76098863
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.73826456
32muscle hypertrophy (GO:0014896)3.71990283
33skeletal muscle tissue development (GO:0007519)3.70835826
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.66116571
35adult heart development (GO:0007512)3.63690990
36glutamate secretion (GO:0014047)3.62848297
37regulation of sequestering of triglyceride (GO:0010889)3.61178926
38heart contraction (GO:0060047)3.58603950
39heart process (GO:0003015)3.58603950
40negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.57540799
41negative regulation of calcium ion transmembrane transport (GO:1903170)3.57540799
42regulation of synaptic vesicle exocytosis (GO:2000300)3.55513026
43cellular polysaccharide catabolic process (GO:0044247)3.54448159
44regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.53824893
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.50738041
46striated muscle adaptation (GO:0014888)3.49227788
47regulation of cell communication by electrical coupling (GO:0010649)3.48473011
48ubiquinone biosynthetic process (GO:0006744)3.46741102
492-oxoglutarate metabolic process (GO:0006103)3.44312345
50regulation of glutamate receptor signaling pathway (GO:1900449)3.41369435
51regulation of skeletal muscle contraction (GO:0014819)3.40705774
52NADH metabolic process (GO:0006734)3.37520080
53actin-myosin filament sliding (GO:0033275)3.37290031
54muscle filament sliding (GO:0030049)3.37290031
55muscle tissue morphogenesis (GO:0060415)3.37123459
56muscle cell cellular homeostasis (GO:0046716)3.34958708
57regulation of synaptic vesicle transport (GO:1902803)3.33460200
58striated muscle cell development (GO:0055002)3.32412212
59plasma membrane repair (GO:0001778)3.32265970
60cardiac muscle cell development (GO:0055013)3.31261206
61regulation of synapse structural plasticity (GO:0051823)3.27640101
62cardiac muscle tissue morphogenesis (GO:0055008)3.25895074
63succinate metabolic process (GO:0006105)3.25484096
64polysaccharide catabolic process (GO:0000272)3.23855820
65relaxation of muscle (GO:0090075)3.22277743
66neurotransmitter secretion (GO:0007269)3.21815781
67synaptic vesicle docking involved in exocytosis (GO:0016081)3.21776228
68response to activity (GO:0014823)3.20341754
69activation of protein kinase A activity (GO:0034199)3.17875958
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17589081
71protein localization to synapse (GO:0035418)3.16494488
72response to caffeine (GO:0031000)3.16299843
73carnitine shuttle (GO:0006853)3.15546353
74regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.15180862
75ionotropic glutamate receptor signaling pathway (GO:0035235)3.14518002
76gamma-aminobutyric acid transport (GO:0015812)3.14364887
77membrane depolarization during action potential (GO:0086010)3.13940673
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12481697
79muscle structure development (GO:0061061)3.12205452
80detection of calcium ion (GO:0005513)3.11422226
81skeletal muscle contraction (GO:0003009)3.10538503
82regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.09937101
83negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09825393
84muscle organ development (GO:0007517)3.09006577
85neuron cell-cell adhesion (GO:0007158)3.08949959
86regulation of membrane repolarization (GO:0060306)3.07620881
87carnitine transmembrane transport (GO:1902603)3.06939828
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05816267
89regulation of calcium ion transmembrane transporter activity (GO:1901019)3.05671494
90regulation of calcium ion transmembrane transport (GO:1903169)3.05671494
91negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.04805529
92ubiquinone metabolic process (GO:0006743)3.04492749
93mitochondrial genome maintenance (GO:0000002)3.03124336
94regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.01602530
95skeletal muscle tissue regeneration (GO:0043403)3.00798209
96relaxation of cardiac muscle (GO:0055119)2.98844320
97cardiac cell development (GO:0055006)2.97531539
98regulation of neuronal synaptic plasticity (GO:0048168)2.96887837
99proline transport (GO:0015824)2.96745564
100regulation of ATPase activity (GO:0043462)2.96213551
101regulation of ATP catabolic process (GO:1903289)2.96213551
102regulation of skeletal muscle cell differentiation (GO:2001014)2.93532588
103* glycogen metabolic process (GO:0005977)2.92818343
104positive regulation of myoblast differentiation (GO:0045663)2.92391548
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.91038504
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.90937738
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90541995
108regulation of sarcomere organization (GO:0060297)2.90304579
109negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.89846142
110cellular potassium ion homeostasis (GO:0030007)2.89773260
111glutamate receptor signaling pathway (GO:0007215)2.88817444
112cardiac muscle adaptation (GO:0014887)2.86520797
113cardiac muscle hypertrophy in response to stress (GO:0014898)2.86520797
114muscle hypertrophy in response to stress (GO:0003299)2.86520797
115aspartate family amino acid catabolic process (GO:0009068)2.86325729
116exploration behavior (GO:0035640)2.85856316
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85549979
118striated muscle contraction (GO:0006941)2.85120759
119regulation of the force of heart contraction (GO:0002026)2.84536373
120neuron-neuron synaptic transmission (GO:0007270)2.84276455
121negative regulation of potassium ion transmembrane transport (GO:1901380)2.83817120
122cell communication by electrical coupling (GO:0010644)2.82555701
123regulation of acyl-CoA biosynthetic process (GO:0050812)2.82083496
124layer formation in cerebral cortex (GO:0021819)2.81196764
125potassium ion import (GO:0010107)2.81086700
126synaptic transmission, glutamatergic (GO:0035249)2.79366122
127fatty acid transmembrane transport (GO:1902001)2.78578289
128actin-mediated cell contraction (GO:0070252)2.78043253
129regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77345619
130neurotransmitter-gated ion channel clustering (GO:0072578)2.74409822
131long-term memory (GO:0007616)2.72424063
132neurotransmitter transport (GO:0006836)2.71971594
133regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68542703
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.66713748
135cell communication involved in cardiac conduction (GO:0086065)2.65291455
136glycogen catabolic process (GO:0005980)2.65044887
137neuromuscular process controlling posture (GO:0050884)2.65025704
138sarcomere organization (GO:0045214)2.62949095
139cardiac muscle contraction (GO:0060048)2.62454029
140myofibril assembly (GO:0030239)2.60832271
141dendritic spine morphogenesis (GO:0060997)2.57659997
142regulation of dendritic spine morphogenesis (GO:0061001)2.57650188
143regulation of cation channel activity (GO:2001257)2.57244009
144regulation of postsynaptic membrane potential (GO:0060078)2.56940611
145glycine transport (GO:0015816)2.56883521
146creatine metabolic process (GO:0006600)2.56681750
147membrane depolarization (GO:0051899)2.55486415
148neuromuscular synaptic transmission (GO:0007274)2.55219963
149neuron recognition (GO:0008038)2.54416598
150regulation of ion transmembrane transporter activity (GO:0032412)2.54391161
151transmission of nerve impulse (GO:0019226)2.53978950
152regulation of coenzyme metabolic process (GO:0051196)2.53277745
153regulation of cofactor metabolic process (GO:0051193)2.53277745
154vesicle transport along microtubule (GO:0047496)2.52935100
155regulation of neurotransmitter levels (GO:0001505)2.52192832
156gamma-aminobutyric acid signaling pathway (GO:0007214)2.49343403
157positive regulation of potassium ion transport (GO:0043268)2.48100558
158positive regulation of cation channel activity (GO:2001259)2.47891236
159sodium ion export (GO:0071436)2.46865111
160regulation of transmembrane transporter activity (GO:0022898)2.46520991
161glucan catabolic process (GO:0009251)2.46047497
162behavioral response to cocaine (GO:0048148)2.44487736
163tricarboxylic acid cycle (GO:0006099)2.44052487
164regulation of sodium ion transmembrane transporter activity (GO:2000649)2.43848420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91274843
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.84933783
3IGF1R_20145208_ChIP-Seq_DFB_Human3.56294206
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84851386
5GBX2_23144817_ChIP-Seq_PC3_Human2.82225203
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68363337
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66866581
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49902129
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36206897
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36206897
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.29837491
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29196369
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24210236
14DROSHA_22980978_ChIP-Seq_HELA_Human2.19756032
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18489560
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16533409
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.16049472
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.14459608
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13130407
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.10840651
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04994346
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.02681327
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01517782
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98817921
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93333387
26AR_21572438_ChIP-Seq_LNCaP_Human1.91304972
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.88095419
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82086990
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81653140
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.76649824
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.75289084
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65814242
33FUS_26573619_Chip-Seq_HEK293_Human1.65494508
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64249779
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56907899
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55939113
37ZNF274_21170338_ChIP-Seq_K562_Hela1.54015818
38TAF15_26573619_Chip-Seq_HEK293_Human1.52298985
39* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51219859
40SMAD4_21799915_ChIP-Seq_A2780_Human1.49427205
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47032990
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46230884
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44731436
44* EZH2_27294783_Chip-Seq_NPCs_Mouse1.44643663
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41003559
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.36652058
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36436176
48NANOG_19829295_ChIP-Seq_ESCs_Human1.35889248
49SOX2_19829295_ChIP-Seq_ESCs_Human1.35889248
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35760644
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34818939
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33146468
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.32682656
54* CRX_20693478_ChIP-Seq_RETINA_Mouse1.32316265
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31971563
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.31318393
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29708500
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29574071
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29004308
60* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27830596
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27818085
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.27196327
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26305346
64* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25515621
65* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24751234
66* CBP_20019798_ChIP-Seq_JUKART_Human1.24751234
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24485891
68* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22340406
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20757934
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20676444
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19991104
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19666444
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18864824
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18420453
75* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18168186
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.17376952
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16976420
78MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16173015
79* AR_25329375_ChIP-Seq_VCAP_Human1.14565312
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13529478
81* SMAD3_21741376_ChIP-Seq_EPCs_Human1.13443311
82P53_22387025_ChIP-Seq_ESCs_Mouse1.12405192
83* STAT3_23295773_ChIP-Seq_U87_Human1.11866133
84* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11577168
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11479267
86P300_19829295_ChIP-Seq_ESCs_Human1.11368063
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.10834675
88TBX20_22080862_ChIP-Seq_HEART_Mouse1.10834675
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10741237
90GATA1_22025678_ChIP-Seq_K562_Human1.10466612
91* AR_19668381_ChIP-Seq_PC3_Human1.09758307
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09432388
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.08781052
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08611469
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07583631
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06510648
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05793820
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04826634
99* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03768422
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03158522
101* CBX2_27304074_Chip-Seq_ESCs_Mouse1.02816345
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02543615
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01940697
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.01654438
105* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01551796
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01335055
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.01030633
108P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99748651
109* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99676912
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.99267788
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99228932
112BCAT_22108803_ChIP-Seq_LS180_Human0.99007994
113CTCF_27219007_Chip-Seq_Bcells_Human0.98915083
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.98476148
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98450108
116TP53_22573176_ChIP-Seq_HFKS_Human0.98309783
117* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97748588
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97457061
119SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97185232
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96753964
121* TCF4_23295773_ChIP-Seq_U87_Human0.96288868
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.95931881
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95836347
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95836347
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95693907
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95546325
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.95429472
128RNF2_27304074_Chip-Seq_NSC_Mouse0.94698167
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.94206023
130* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94005556
131AHR_22903824_ChIP-Seq_MCF-7_Human0.93741765
132IRF8_22096565_ChIP-ChIP_GC-B_Human0.93403521
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92949022
134AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91340579
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91233893
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91109627
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.90500580
138* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89417393
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88721624
140* ER_23166858_ChIP-Seq_MCF-7_Human0.88161185
141CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88041225
142* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86946455
143OCT4_20526341_ChIP-Seq_ESCs_Human0.86432262
144* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85320288
145* KDM2B_26808549_Chip-Seq_K562_Human0.85253210
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84387040
147VDR_22108803_ChIP-Seq_LS180_Human0.83888429
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83137728
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.81437437
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.81177757
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80887711
152* FLI1_21867929_ChIP-Seq_TH2_Mouse0.79875033
153RUNX2_22187159_ChIP-Seq_PCA_Human0.79839572
154KLF4_19829295_ChIP-Seq_ESCs_Human0.79749324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.57622335
2MP0002837_dystrophic_cardiac_calcinosis3.66635557
3MP0004145_abnormal_muscle_electrophysio3.65365631
4MP0003646_muscle_fatigue3.58652060
5MP0004270_analgesia3.27697493
6MP0000751_myopathy3.26759505
7MP0003880_abnormal_central_pattern3.15229786
8MP0003635_abnormal_synaptic_transmissio2.94906683
9MP0000749_muscle_degeneration2.67460442
10MP0009745_abnormal_behavioral_response2.48624078
11MP0004036_abnormal_muscle_relaxation2.45738440
12MP0002822_catalepsy2.42131134
13MP0004130_abnormal_muscle_cell2.32613437
14* MP0002064_seizures2.31928915
15* MP0002063_abnormal_learning/memory/cond2.26728908
16* MP0009046_muscle_twitch2.25200136
17MP0001968_abnormal_touch/_nociception2.05725391
18MP0002734_abnormal_mechanical_nocicepti2.03083222
19* MP0002272_abnormal_nervous_system1.99717006
20* MP0000747_muscle_weakness1.97236377
21MP0004215_abnormal_myocardial_fiber1.89062041
22MP0002572_abnormal_emotion/affect_behav1.86221956
23MP0000372_irregular_coat_pigmentation1.84156169
24MP0005620_abnormal_muscle_contractility1.83282318
25MP0001440_abnormal_grooming_behavior1.81310381
26* MP0001486_abnormal_startle_reflex1.79183439
27MP0002106_abnormal_muscle_physiology1.77502564
28MP0002735_abnormal_chemical_nociception1.74648019
29MP0001501_abnormal_sleep_pattern1.71823676
30MP0005451_abnormal_body_composition1.66059481
31MP0002909_abnormal_adrenal_gland1.65737572
32MP0009780_abnormal_chondrocyte_physiolo1.65123216
33MP0004084_abnormal_cardiac_muscle1.64681453
34MP0002269_muscular_atrophy1.59884738
35MP0000759_abnormal_skeletal_muscle1.59438696
36MP0002067_abnormal_sensory_capabilities1.58422335
37MP0004087_abnormal_muscle_fiber1.57891221
38MP0004147_increased_porphyrin_level1.57414120
39MP0002736_abnormal_nociception_after1.57104004
40MP0005266_abnormal_metabolism1.55675374
41MP0008569_lethality_at_weaning1.50733786
42MP0004233_abnormal_muscle_weight1.50245806
43MP0005423_abnormal_somatic_nervous1.48910175
44MP0005369_muscle_phenotype1.47588442
45MP0003329_amyloid_beta_deposits1.46676478
46MP0002733_abnormal_thermal_nociception1.44596269
47MP0004858_abnormal_nervous_system1.43409591
48MP0001970_abnormal_pain_threshold1.42829568
49MP0004484_altered_response_of1.41445729
50MP0004924_abnormal_behavior1.40277761
51MP0005386_behavior/neurological_phenoty1.40277761
52MP0005330_cardiomyopathy1.38974197
53MP0000013_abnormal_adipose_tissue1.34393205
54MP0002127_abnormal_cardiovascular_syste1.33748079
55MP0004043_abnormal_pH_regulation1.32784107
56MP0000733_abnormal_muscle_development1.31257045
57MP0008877_abnormal_DNA_methylation1.28261249
58MP0010630_abnormal_cardiac_muscle1.25869214
59MP0005646_abnormal_pituitary_gland1.24142911
60MP0004085_abnormal_heartbeat1.22610113
61MP0003137_abnormal_impulse_conducting1.22148679
62MP0004142_abnormal_muscle_tone1.20491867
63MP0004885_abnormal_endolymph1.20349938
64MP0001661_extended_life_span1.19753053
65MP0006276_abnormal_autonomic_nervous1.18918674
66MP0002972_abnormal_cardiac_muscle1.18046100
67* MP0002066_abnormal_motor_capabilities/c1.17684701
68MP0005535_abnormal_body_temperature1.16053117
69MP0003879_abnormal_hair_cell1.15696277
70MP0003950_abnormal_plasma_membrane1.14010806
71MP0002184_abnormal_innervation1.13134981
72MP0002557_abnormal_social/conspecific_i1.12466698
73MP0000750_abnormal_muscle_regeneration1.10845452
74MP0005670_abnormal_white_adipose1.10751927
75MP0003633_abnormal_nervous_system1.09926907
76MP0000955_abnormal_spinal_cord1.07983245
77MP0004510_myositis1.06616449
78MP0001984_abnormal_olfaction1.03688375
79* MP0004811_abnormal_neuron_physiology1.03190821
80MP0002876_abnormal_thyroid_physiology1.02159944
81MP0006036_abnormal_mitochondrial_physio1.01731657
82MP0002332_abnormal_exercise_endurance1.00885880
83MP0003690_abnormal_glial_cell0.99788912
84* MP0002882_abnormal_neuron_morphology0.98744481
85* MP0002229_neurodegeneration0.94766513
86MP0000778_abnormal_nervous_system0.93061193
87MP0001529_abnormal_vocalization0.89728480
88MP0005551_abnormal_eye_electrophysiolog0.88698641
89MP0005167_abnormal_blood-brain_barrier0.87158519
90MP0004185_abnormal_adipocyte_glucose0.84140747
91MP0001502_abnormal_circadian_rhythm0.83573772
92MP0001905_abnormal_dopamine_level0.83566539
93MP0008775_abnormal_heart_ventricle0.83154617
94MP0003631_nervous_system_phenotype0.82982646
95MP0008874_decreased_physiological_sensi0.82517008
96MP0002078_abnormal_glucose_homeostasis0.81280832
97MP0002638_abnormal_pupillary_reflex0.79679704
98MP0002971_abnormal_brown_adipose0.78203472
99MP0000920_abnormal_myelination0.77932862
100MP0006138_congestive_heart_failure0.77818690
101MP0005666_abnormal_adipose_tissue0.77461295
102MP0002069_abnormal_eating/drinking_beha0.76162608
103MP0003195_calcinosis0.76017821
104MP0005085_abnormal_gallbladder_physiolo0.75024759
105MP0006035_abnormal_mitochondrial_morpho0.73678331
106MP0008961_abnormal_basal_metabolism0.72986460
107MP0003656_abnormal_erythrocyte_physiolo0.72524112
108MP0001544_abnormal_cardiovascular_syste0.72379068
109MP0005385_cardiovascular_system_phenoty0.72379068
110MP0005645_abnormal_hypothalamus_physiol0.72317507
111MP0002108_abnormal_muscle_morphology0.70915391
112MP0002090_abnormal_vision0.70882418
113MP0000230_abnormal_systemic_arterial0.68476740
114MP0003045_fibrosis0.67765314
115MP0003221_abnormal_cardiomyocyte_apopto0.67346586
116MP0002234_abnormal_pharynx_morphology0.66684952
117MP0003634_abnormal_glial_cell0.65925772
118MP0005253_abnormal_eye_physiology0.65087907
119MP0003787_abnormal_imprinting0.64550732
120MP0000003_abnormal_adipose_tissue0.62331310
121MP0001986_abnormal_taste_sensitivity0.61438610
122MP0005187_abnormal_penis_morphology0.60973346
123MP0004134_abnormal_chest_morphology0.59438444
124MP0001299_abnormal_eye_distance/0.57836212
125MP0005375_adipose_tissue_phenotype0.55514773
126MP0003828_pulmonary_edema0.54100069
127MP0005171_absent_coat_pigmentation0.54016410
128MP0008872_abnormal_physiological_respon0.53661598
129MP0005332_abnormal_amino_acid0.53599901
130MP0000631_abnormal_neuroendocrine_gland0.46160058
131MP0002102_abnormal_ear_morphology0.46020557

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.11990011
2Exercise-induced muscle cramps (HP:0003710)5.17668566
3Muscle hypertrophy of the lower extremities (HP:0008968)4.97095509
4Calf muscle hypertrophy (HP:0008981)4.64807651
5Muscle fiber inclusion bodies (HP:0100299)4.62723492
6* Focal motor seizures (HP:0011153)4.60595067
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.35071742
8Myokymia (HP:0002411)4.18164510
9Nemaline bodies (HP:0003798)3.92658883
10Myoglobinuria (HP:0002913)3.80308409
11Centrally nucleated skeletal muscle fibers (HP:0003687)3.68784824
12Difficulty running (HP:0009046)3.68129689
13Muscle fiber splitting (HP:0003555)3.56444222
14Sudden death (HP:0001699)3.54640613
15Hyporeflexia of lower limbs (HP:0002600)3.54543851
16Myotonia (HP:0002486)3.53467094
17* Focal seizures (HP:0007359)3.38932798
18Abnormality of the calf musculature (HP:0001430)3.36321397
19Atonic seizures (HP:0010819)3.32764824
20Distal arthrogryposis (HP:0005684)3.30278544
21Type 1 muscle fiber predominance (HP:0003803)3.29838887
22* Visual hallucinations (HP:0002367)3.21983595
23EMG: myopathic abnormalities (HP:0003458)3.16896781
24Calcaneovalgus deformity (HP:0001848)3.14224254
25Muscle stiffness (HP:0003552)3.10974711
26Myopathic facies (HP:0002058)3.03045782
27Bundle branch block (HP:0011710)2.99762888
28Abnormal finger flexion creases (HP:0006143)2.97773248
29Distal lower limb muscle weakness (HP:0009053)2.87937550
30Febrile seizures (HP:0002373)2.82966601
31Deformed tarsal bones (HP:0008119)2.79960102
32* Generalized tonic-clonic seizures (HP:0002069)2.76271899
33Round ear (HP:0100830)2.74495076
34* Absence seizures (HP:0002121)2.69359014
35Generalized muscle weakness (HP:0003324)2.66217498
36Rhabdomyolysis (HP:0003201)2.66110830
37Malignant hyperthermia (HP:0002047)2.62969748
38Action tremor (HP:0002345)2.61316711
39Epileptic encephalopathy (HP:0200134)2.60698013
40Dilated cardiomyopathy (HP:0001644)2.60036802
41Pheochromocytoma (HP:0002666)2.56259192
42Ventricular fibrillation (HP:0001663)2.54504286
43Broad-based gait (HP:0002136)2.53575768
44Impaired vibration sensation in the lower limbs (HP:0002166)2.52470232
45* Dialeptic seizures (HP:0011146)2.50192201
46Ankle clonus (HP:0011448)2.50143216
47Increased variability in muscle fiber diameter (HP:0003557)2.46003199
48Lipoatrophy (HP:0100578)2.44974636
49Poor eye contact (HP:0000817)2.43108132
50Syncope (HP:0001279)2.40656117
51Asymmetric septal hypertrophy (HP:0001670)2.40654037
52Progressive cerebellar ataxia (HP:0002073)2.39728523
53Heart block (HP:0012722)2.36613113
54Abnormal social behavior (HP:0012433)2.36248608
55Impaired social interactions (HP:0000735)2.36248608
56Urinary bladder sphincter dysfunction (HP:0002839)2.34303369
57Supranuclear gaze palsy (HP:0000605)2.32747691
58Abnormality of the left ventricular outflow tract (HP:0011103)2.29174082
59Subaortic stenosis (HP:0001682)2.29174082
60Dysdiadochokinesis (HP:0002075)2.28503090
61Abnormality of skeletal muscle fiber size (HP:0012084)2.27902035
62Anxiety (HP:0000739)2.27712299
63Muscular dystrophy (HP:0003560)2.27568293
64Neuroendocrine neoplasm (HP:0100634)2.24001465
65Urinary urgency (HP:0000012)2.23672990
66Dysmetric saccades (HP:0000641)2.23296497
67Prolonged QT interval (HP:0001657)2.23185345
68Gowers sign (HP:0003391)2.22785298
69Dysmetria (HP:0001310)2.21890870
70Difficulty climbing stairs (HP:0003551)2.21865768
71Atrioventricular block (HP:0001678)2.20605091
72Hyperkalemia (HP:0002153)2.18936325
73Depression (HP:0000716)2.18852819
74Fetal akinesia sequence (HP:0001989)2.17049906
75Postural instability (HP:0002172)2.16894733
76Ventricular arrhythmia (HP:0004308)2.16054155
77Abnormal atrioventricular conduction (HP:0005150)2.16005396
78Weak cry (HP:0001612)2.14994083
79Rimmed vacuoles (HP:0003805)2.13495300
80Increased intramyocellular lipid droplets (HP:0012240)2.12698071
81Hyperventilation (HP:0002883)2.12301546
82Increased connective tissue (HP:0009025)2.11116284
83Ulnar deviation of the wrist (HP:0003049)2.10566283
84Ketoacidosis (HP:0001993)2.08194350
85Gout (HP:0001997)2.07105680
86Atrial fibrillation (HP:0005110)2.06700157
87Oligomenorrhea (HP:0000876)2.06215753
88EMG: neuropathic changes (HP:0003445)2.04717345
89Scapular winging (HP:0003691)2.03083613
90Shoulder girdle muscle weakness (HP:0003547)2.02432260
91Abnormal EKG (HP:0003115)2.00458834
92Primary atrial arrhythmia (HP:0001692)1.99194664
93Neck muscle weakness (HP:0000467)1.99176210
94Bulbar palsy (HP:0001283)1.97863484
95Exercise intolerance (HP:0003546)1.97003087
96Gaze-evoked nystagmus (HP:0000640)1.96579502
97Fatigable weakness (HP:0003473)1.96378687
98Abnormality of the neuromuscular junction (HP:0003398)1.96378687
99Absent phalangeal crease (HP:0006109)1.96223970
100Type 2 muscle fiber atrophy (HP:0003554)1.95496997
101Increased muscle lipid content (HP:0009058)1.94164145
102Ventricular tachycardia (HP:0004756)1.94017231
103Central scotoma (HP:0000603)1.92072615
104Limb-girdle muscle atrophy (HP:0003797)1.90501376
105Cerebral inclusion bodies (HP:0100314)1.87164725
106Frequent falls (HP:0002359)1.86204907
107Areflexia of lower limbs (HP:0002522)1.86120635
108Lower limb muscle weakness (HP:0007340)1.85425978
109Left ventricular hypertrophy (HP:0001712)1.84969407
110Abnormality of the corticospinal tract (HP:0002492)1.84708080
111Insidious onset (HP:0003587)1.84676655
112Termporal pattern (HP:0011008)1.84676655
113Abnormality of the shoulder girdle musculature (HP:0001435)1.83750483
114Supraventricular tachycardia (HP:0004755)1.83702379
115Lower limb amyotrophy (HP:0007210)1.83433843
116Proximal amyotrophy (HP:0007126)1.83341467
117Waddling gait (HP:0002515)1.83189377
118Progressive inability to walk (HP:0002505)1.83184471
119Hip contracture (HP:0003273)1.82419525
120Neurofibrillary tangles (HP:0002185)1.82099071
121Acute necrotizing encephalopathy (HP:0006965)1.81151043
122Spastic gait (HP:0002064)1.80777224
123Insulin-resistant diabetes mellitus (HP:0000831)1.79226861
124Abnormal mitochondria in muscle tissue (HP:0008316)1.77974599
125Abnormality of the musculature of the pelvis (HP:0001469)1.77417472
126Abnormality of the hip-girdle musculature (HP:0001445)1.77417472
127Abnormality of the foot musculature (HP:0001436)1.77112171
128Supraventricular arrhythmia (HP:0005115)1.76894428
129Resting tremor (HP:0002322)1.76633768
130Facial diplegia (HP:0001349)1.76542283
131Nonprogressive disorder (HP:0003680)1.76175156
132Ragged-red muscle fibers (HP:0003200)1.73325630
133Slender build (HP:0001533)1.72294433
134Distal lower limb amyotrophy (HP:0008944)1.71086631
135Mildly elevated creatine phosphokinase (HP:0008180)1.66592462
136Long clavicles (HP:0000890)1.66445331
137Mitochondrial inheritance (HP:0001427)1.63101414
138Respiratory insufficiency due to muscle weakness (HP:0002747)1.60874171
139Progressive macrocephaly (HP:0004481)1.59892867
140Muscle fiber atrophy (HP:0100295)1.59737031
141Progressive muscle weakness (HP:0003323)1.58198054
142Palpitations (HP:0001962)1.56026455
143Acute encephalopathy (HP:0006846)1.55407494
144Type II lissencephaly (HP:0007260)1.52619749
145Increased CSF lactate (HP:0002490)1.50163374
146Steppage gait (HP:0003376)1.49794374
147Foot dorsiflexor weakness (HP:0009027)1.48316837
148Abnormality of the calcaneus (HP:0008364)1.47916050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.36343931
2OBSCN3.32258440
3PHKG13.27033156
4PHKG23.27033156
5EPHA43.04592961
6MAP3K93.01196197
7MAP3K42.51907081
8MAP2K42.50943551
9TTN2.25828180
10PINK12.22022614
11MARK12.14756503
12KSR22.12801457
13PAK62.06408343
14NME11.89086573
15MAP2K71.86553563
16MINK11.78283556
17DAPK21.72389592
18PDK31.62058756
19PDK41.62058756
20MAP2K31.51915559
21FRK1.49163053
22NTRK11.42579174
23GRK51.41868431
24NTRK21.34144755
25RIPK41.32154467
26PRKD31.30623123
27NEK11.25773115
28ARAF1.23539968
29STK381.22265846
30LATS21.21994580
31MAPKAPK31.21457152
32CAMKK11.20701850
33TRPM71.17825587
34NUAK11.16404054
35MAP3K71.15440940
36KSR11.14838198
37DMPK1.14591406
38CASK1.14005054
39LMTK21.13780589
40CDK51.10993320
41ERBB31.05860623
42MAP3K21.01852791
43VRK21.01089728
44MAP3K121.00847520
45MAPK120.98150230
46PDK20.97849522
47SGK2230.97418931
48SGK4940.97418931
49CAMK2A0.96102489
50TIE10.94762874
51PRKCG0.90015528
52RET0.89559291
53PIK3CA0.88029450
54PLK20.86222248
55PRPF4B0.85919554
56MUSK0.84293263
57MAP3K130.84142817
58PAK30.84087253
59PRKCH0.83220044
60CCNB10.82621919
61INSRR0.79306735
62SGK20.78785820
63OXSR10.78563306
64BCKDK0.77292482
65PDPK10.76671791
66MAPKAPK50.76612016
67TRIB30.76072284
68CAMK40.75983656
69PNCK0.75899006
70PDK10.75667450
71GRK70.75600852
72PIK3CG0.75199504
73CAMK10.74454649
74CAMKK20.74408733
75STK110.73963490
76CAMK2G0.72042873
77SGK10.71565374
78SGK30.71472315
79PRKAA10.69777764
80CAMK2D0.68379820
81MAPK130.68297908
82SIK20.67761972
83TNIK0.66227670
84CAMK1G0.66039086
85MAP3K60.65688129
86MAP3K10.65217008
87RAF10.64640327
88CDK190.62016980
89PKN10.61696717
90MAPK110.61603714
91WNK10.60529030
92TGFBR20.59515270
93UHMK10.58458807
94FES0.57919012
95CAMK2B0.57360700
96PRKG10.55991696
97ADRBK20.55638845
98TYRO30.55026153
99CSNK1G20.53521088
100MARK20.53484680
101RPS6KA30.53067468
102MAPK40.52796112
103GRK10.52245455
104BMPR20.51956146
105PRKAA20.51413764
106AKT30.51159748
107MAP2K10.49976036
108MAP4K20.49527836
109PTK2B0.48246548
110BMPR1B0.48070183
111STK390.47172837
112RPS6KB10.46805684
113WNK30.46782549
114DYRK30.46708710
115TAOK10.46305927
116MAPK70.45985560
117CSNK1G10.45961550
118SYK0.45948172
119PRKACA0.45383375
120MAP2K60.45114922
121PRKCE0.45061608
122DYRK1A0.44947180
123CDC42BPA0.44559903
124CSNK1G30.44382857
125NLK0.44136525
126DYRK1B0.43801462
127TNK20.42747352
128VRK10.42296093
129DAPK10.41993015
130ZAK0.41797633
131MOS0.36694003
132STK38L0.33983439
133LIMK10.33861506
134CSNK1D0.32661140
135PRKCQ0.31498271
136ROCK10.31346415
137PRKACB0.31128585
138DYRK20.29365120
139EEF2K0.28998274
140CSNK1A1L0.28029145
141TAF10.27828560
142PRKACG0.25024099
143AKT20.23234812
144WNK40.23228348
145MAPK100.20803995

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.49699993
2Synaptic vesicle cycle_Homo sapiens_hsa047212.27974675
3GABAergic synapse_Homo sapiens_hsa047272.17169181
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07033048
5Circadian entrainment_Homo sapiens_hsa047132.01231809
6Olfactory transduction_Homo sapiens_hsa047401.93030848
7Cardiac muscle contraction_Homo sapiens_hsa042601.92478497
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90718605
9Long-term potentiation_Homo sapiens_hsa047201.90176126
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88226194
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.85680704
12Nitrogen metabolism_Homo sapiens_hsa009101.84043882
13Morphine addiction_Homo sapiens_hsa050321.84012415
14Glutamatergic synapse_Homo sapiens_hsa047241.81966009
15Insulin secretion_Homo sapiens_hsa049111.76694907
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69505691
17Amphetamine addiction_Homo sapiens_hsa050311.65773183
18Oxytocin signaling pathway_Homo sapiens_hsa049211.60014257
19Salivary secretion_Homo sapiens_hsa049701.59899915
20Gastric acid secretion_Homo sapiens_hsa049711.58140748
21Arginine and proline metabolism_Homo sapiens_hsa003301.57589920
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55626702
23Dilated cardiomyopathy_Homo sapiens_hsa054141.52383121
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50476161
25Calcium signaling pathway_Homo sapiens_hsa040201.50290951
26Dopaminergic synapse_Homo sapiens_hsa047281.48896564
27Cholinergic synapse_Homo sapiens_hsa047251.46469701
28Butanoate metabolism_Homo sapiens_hsa006501.46308111
29Renin secretion_Homo sapiens_hsa049241.44802889
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39896291
31Taste transduction_Homo sapiens_hsa047421.37024614
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29520196
33Propanoate metabolism_Homo sapiens_hsa006401.29367201
34Arginine biosynthesis_Homo sapiens_hsa002201.27572263
35Peroxisome_Homo sapiens_hsa041461.25258657
36Long-term depression_Homo sapiens_hsa047301.24561456
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21341111
38Serotonergic synapse_Homo sapiens_hsa047261.20308350
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19650022
40Type II diabetes mellitus_Homo sapiens_hsa049301.19507327
41GnRH signaling pathway_Homo sapiens_hsa049121.17347618
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14648716
43Regulation of autophagy_Homo sapiens_hsa041401.11310602
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11016861
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09460780
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09183360
47Oxidative phosphorylation_Homo sapiens_hsa001901.05579989
48Glucagon signaling pathway_Homo sapiens_hsa049221.04577156
49Alzheimers disease_Homo sapiens_hsa050101.03601776
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03525907
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03145220
52Collecting duct acid secretion_Homo sapiens_hsa049661.02792781
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.01463830
54cAMP signaling pathway_Homo sapiens_hsa040240.99023120
55Tryptophan metabolism_Homo sapiens_hsa003800.97667110
56Cocaine addiction_Homo sapiens_hsa050300.95950211
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92426126
58Parkinsons disease_Homo sapiens_hsa050120.91780849
59Circadian rhythm_Homo sapiens_hsa047100.88982531
60Gap junction_Homo sapiens_hsa045400.88792295
61Pentose phosphate pathway_Homo sapiens_hsa000300.88365599
62Sulfur relay system_Homo sapiens_hsa041220.87693562
63Insulin signaling pathway_Homo sapiens_hsa049100.86466087
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86029204
65Fatty acid degradation_Homo sapiens_hsa000710.82570592
66Bile secretion_Homo sapiens_hsa049760.82392492
67Fatty acid metabolism_Homo sapiens_hsa012120.82318531
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81713074
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80607455
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80154204
71Phototransduction_Homo sapiens_hsa047440.78668812
72Dorso-ventral axis formation_Homo sapiens_hsa043200.77672442
73Estrogen signaling pathway_Homo sapiens_hsa049150.75720786
74Pyruvate metabolism_Homo sapiens_hsa006200.73266682
75Carbon metabolism_Homo sapiens_hsa012000.72422433
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72371459
77Starch and sucrose metabolism_Homo sapiens_hsa005000.69096257
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67572138
79Pancreatic secretion_Homo sapiens_hsa049720.67528319
80Melanogenesis_Homo sapiens_hsa049160.65742020
81Glioma_Homo sapiens_hsa052140.64119921
82RNA degradation_Homo sapiens_hsa030180.63693794
83Purine metabolism_Homo sapiens_hsa002300.62799614
84Insulin resistance_Homo sapiens_hsa049310.62698450
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62627740
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.61551329
87ErbB signaling pathway_Homo sapiens_hsa040120.61325096
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60801718
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60233034
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60188038
91Linoleic acid metabolism_Homo sapiens_hsa005910.58657609
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57869061
93Phenylalanine metabolism_Homo sapiens_hsa003600.57175003
94Primary immunodeficiency_Homo sapiens_hsa053400.56803295
95PPAR signaling pathway_Homo sapiens_hsa033200.54804122
96Fatty acid biosynthesis_Homo sapiens_hsa000610.54164483
97Axon guidance_Homo sapiens_hsa043600.54067293
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.53735030
99AMPK signaling pathway_Homo sapiens_hsa041520.53579120
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.52462747
101Ovarian steroidogenesis_Homo sapiens_hsa049130.52306011
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49387816
103mTOR signaling pathway_Homo sapiens_hsa041500.48606142
104MAPK signaling pathway_Homo sapiens_hsa040100.48201468
105Caffeine metabolism_Homo sapiens_hsa002320.46328337
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45627744
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45188578
108Vitamin B6 metabolism_Homo sapiens_hsa007500.44831722
109Thyroid hormone synthesis_Homo sapiens_hsa049180.44782801
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.44756727
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.44600254
112Choline metabolism in cancer_Homo sapiens_hsa052310.43808579
113Lysine degradation_Homo sapiens_hsa003100.43237868
114Fatty acid elongation_Homo sapiens_hsa000620.42706245
115Huntingtons disease_Homo sapiens_hsa050160.42408023
116beta-Alanine metabolism_Homo sapiens_hsa004100.42034978
117Vibrio cholerae infection_Homo sapiens_hsa051100.41986155
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41217164
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40814733
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40348360
121FoxO signaling pathway_Homo sapiens_hsa040680.40152132
122Viral myocarditis_Homo sapiens_hsa054160.38309087
123RNA polymerase_Homo sapiens_hsa030200.34686265
124Metabolic pathways_Homo sapiens_hsa011000.33255197
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30067299
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29468000
127Tyrosine metabolism_Homo sapiens_hsa003500.23380153
128ABC transporters_Homo sapiens_hsa020100.23349450

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