EPHX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.54753531
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.50910517
3L-phenylalanine catabolic process (GO:0006559)6.50910517
4L-phenylalanine metabolic process (GO:0006558)6.27153180
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.27153180
6ethanol metabolic process (GO:0006067)5.98034841
7aromatic amino acid family catabolic process (GO:0009074)5.94236395
8primary alcohol catabolic process (GO:0034310)5.77835802
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.73371097
10alpha-linolenic acid metabolic process (GO:0036109)5.44363896
11indole-containing compound catabolic process (GO:0042436)5.44055346
12indolalkylamine catabolic process (GO:0046218)5.44055346
13tryptophan catabolic process (GO:0006569)5.44055346
14bile acid biosynthetic process (GO:0006699)5.43284261
15negative regulation of fibrinolysis (GO:0051918)5.41605395
16kynurenine metabolic process (GO:0070189)5.38488506
17omega-hydroxylase P450 pathway (GO:0097267)5.35330903
18sulfur amino acid catabolic process (GO:0000098)5.20606794
19regulation of fibrinolysis (GO:0051917)5.15784585
20high-density lipoprotein particle remodeling (GO:0034375)5.15118104
21peptidyl-glutamic acid carboxylation (GO:0017187)5.14668933
22protein carboxylation (GO:0018214)5.14668933
23glyoxylate metabolic process (GO:0046487)5.12545538
24tryptophan metabolic process (GO:0006568)5.09564167
25regulation of protein activation cascade (GO:2000257)5.06053685
26urea metabolic process (GO:0019627)5.02475109
27urea cycle (GO:0000050)5.02475109
28complement activation, alternative pathway (GO:0006957)4.99984548
29cysteine metabolic process (GO:0006534)4.92081013
30daunorubicin metabolic process (GO:0044597)4.89006903
31polyketide metabolic process (GO:0030638)4.89006903
32doxorubicin metabolic process (GO:0044598)4.89006903
33cellular glucuronidation (GO:0052695)4.80994598
34regulation of complement activation (GO:0030449)4.79908507
35response to nitrosative stress (GO:0051409)4.72678113
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.68286116
37nitrogen cycle metabolic process (GO:0071941)4.60236335
38bile acid metabolic process (GO:0008206)4.55985466
39reverse cholesterol transport (GO:0043691)4.55646930
40regulation of cholesterol esterification (GO:0010872)4.54620194
41glucuronate metabolic process (GO:0019585)4.41688263
42uronic acid metabolic process (GO:0006063)4.41688263
43xenobiotic catabolic process (GO:0042178)4.40582053
44regulation of triglyceride catabolic process (GO:0010896)4.38661757
45benzene-containing compound metabolic process (GO:0042537)4.36873491
46phospholipid efflux (GO:0033700)4.34286529
47protein-lipid complex remodeling (GO:0034368)4.34171598
48macromolecular complex remodeling (GO:0034367)4.34171598
49plasma lipoprotein particle remodeling (GO:0034369)4.34171598
50serine family amino acid catabolic process (GO:0009071)4.31451957
51aminoglycoside antibiotic metabolic process (GO:0030647)4.31001244
52aromatic amino acid family metabolic process (GO:0009072)4.28837059
53homocysteine metabolic process (GO:0050667)4.26352653
54amino-acid betaine metabolic process (GO:0006577)4.25186984
55regulation of apoptotic cell clearance (GO:2000425)4.23634453
56tyrosine metabolic process (GO:0006570)4.21564657
57drug metabolic process (GO:0017144)4.17718227
58plasma lipoprotein particle clearance (GO:0034381)4.16894955
59negative regulation of sterol transport (GO:0032372)4.16772936
60negative regulation of cholesterol transport (GO:0032375)4.16772936
61ethanol oxidation (GO:0006069)4.15420726
62acylglycerol homeostasis (GO:0055090)4.13166547
63triglyceride homeostasis (GO:0070328)4.13166547
64lysine catabolic process (GO:0006554)4.12426505
65lysine metabolic process (GO:0006553)4.12426505
66blood coagulation, intrinsic pathway (GO:0007597)4.08261706
67alpha-amino acid catabolic process (GO:1901606)3.98127564
68cholesterol efflux (GO:0033344)3.97137457
69fibrinolysis (GO:0042730)3.94518419
70bile acid and bile salt transport (GO:0015721)3.90412201
71coenzyme catabolic process (GO:0009109)3.81946754
72negative regulation of blood coagulation (GO:0030195)3.79344823
73negative regulation of hemostasis (GO:1900047)3.79344823
74regulation of cholesterol homeostasis (GO:2000188)3.78571257
75epoxygenase P450 pathway (GO:0019373)3.77254589
76cellular ketone body metabolic process (GO:0046950)3.76633091
77aldehyde catabolic process (GO:0046185)3.76053309
78indolalkylamine metabolic process (GO:0006586)3.75840636
79primary alcohol metabolic process (GO:0034308)3.71512299
80cellular amino acid catabolic process (GO:0009063)3.71429195
81axonemal dynein complex assembly (GO:0070286)3.70718680
82cellular biogenic amine catabolic process (GO:0042402)3.70080295
83amine catabolic process (GO:0009310)3.70080295
84negative regulation of lipase activity (GO:0060192)3.67160818
85cellular modified amino acid catabolic process (GO:0042219)3.66567975
86glutamate metabolic process (GO:0006536)3.65074414
87plasma lipoprotein particle assembly (GO:0034377)3.64091171
88regulation of humoral immune response (GO:0002920)3.62988873
89positive regulation of lipid catabolic process (GO:0050996)3.62169408
90imidazole-containing compound metabolic process (GO:0052803)3.60766669
91glycine metabolic process (GO:0006544)3.60008982
92low-density lipoprotein particle remodeling (GO:0034374)3.59757894
93phospholipid homeostasis (GO:0055091)3.57337610
94drug catabolic process (GO:0042737)3.55528265
95serine family amino acid metabolic process (GO:0009069)3.55110377
96positive regulation of fatty acid beta-oxidation (GO:0032000)3.54182071
97dicarboxylic acid biosynthetic process (GO:0043650)3.51086028
98complement activation, classical pathway (GO:0006958)3.51006382
99regulation of plasminogen activation (GO:0010755)3.49202128
100complement activation (GO:0006956)3.49118993
101regulation of cholesterol biosynthetic process (GO:0045540)3.49049335
102progesterone metabolic process (GO:0042448)3.47753896
103negative regulation of coagulation (GO:0050819)3.47476631
104arginine metabolic process (GO:0006525)3.47275728
105positive regulation of lipoprotein lipase activity (GO:0051006)3.46376420
106positive regulation of triglyceride lipase activity (GO:0061365)3.46376420
107cholesterol homeostasis (GO:0042632)3.46157465
108opsonization (GO:0008228)3.45278226
109phenylpropanoid metabolic process (GO:0009698)3.44240039
110negative regulation of protein activation cascade (GO:2000258)3.42972458
111intestinal cholesterol absorption (GO:0030299)3.42955228
112very-low-density lipoprotein particle assembly (GO:0034379)3.42498240
113sterol homeostasis (GO:0055092)3.40886779
114cofactor catabolic process (GO:0051187)3.39800392
115protein activation cascade (GO:0072376)3.39395992
116acute-phase response (GO:0006953)3.38834678
117regulation of bile acid biosynthetic process (GO:0070857)3.38371269
118protein-lipid complex assembly (GO:0065005)3.36785244
119regulation of cholesterol metabolic process (GO:0090181)3.36608276
120positive regulation of hemostasis (GO:1900048)3.36350656
121positive regulation of blood coagulation (GO:0030194)3.36350656
122negative regulation of wound healing (GO:0061045)3.36292846
123lipoprotein metabolic process (GO:0042157)3.35777995
124flavonoid metabolic process (GO:0009812)3.32688889
125positive regulation of fatty acid biosynthetic process (GO:0045723)3.20481229
126negative regulation of lipid transport (GO:0032369)3.19272617
127positive regulation of coagulation (GO:0050820)3.16489173
128response to mercury ion (GO:0046689)3.15709762
129negative regulation of humoral immune response (GO:0002921)3.13689748
130negative regulation of fatty acid biosynthetic process (GO:0045717)3.09475276
131oxidative demethylation (GO:0070989)3.08217446
132positive regulation of extracellular matrix organization (GO:1903055)3.06343252
133negative regulation of complement activation (GO:0045916)2.95719646
134xenobiotic metabolic process (GO:0006805)2.91899942
135carnitine metabolic process (GO:0009437)2.91009034
136low-density lipoprotein particle clearance (GO:0034383)2.89836756
137fat-soluble vitamin biosynthetic process (GO:0042362)2.89509479
138androgen biosynthetic process (GO:0006702)2.88296573
139C21-steroid hormone metabolic process (GO:0008207)2.81964953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.20697401
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.25319440
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.73816799
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.65803806
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89830933
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.43879590
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.95940165
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.67825300
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.95156526
10* CLOCK_20551151_ChIP-Seq_293T_Human2.38693040
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35431038
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31530462
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.18964153
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11479295
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1616955
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.88680708
17* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.86708022
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71144239
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63475344
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58365895
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53787409
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.50300812
23SMC4_20622854_ChIP-Seq_HELA_Human1.44454238
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.43165957
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41790255
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38801437
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.38588189
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32427990
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31122840
30* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30644372
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.28585646
32ZNF263_19887448_ChIP-Seq_K562_Human1.25587389
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24386492
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.23906355
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22464365
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21324666
37* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20681462
38* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20681462
39KDM2B_26808549_Chip-Seq_K562_Human1.19040436
40* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18825280
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17550289
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.16864936
43DROSHA_22980978_ChIP-Seq_HELA_Human1.15159222
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13962036
45NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13098457
46CREB1_26743006_Chip-Seq_LNCaP_Human1.11444895
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10906155
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.10765637
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09295176
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08256720
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08077502
52GATA1_22025678_ChIP-Seq_K562_Human1.07643640
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07173796
54SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06620016
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05390425
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04634320
57* CTCF_27219007_Chip-Seq_Bcells_Human1.03294940
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02122213
59* P68_20966046_ChIP-Seq_HELA_Human1.00240016
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99893340
61GATA4_25053715_ChIP-Seq_YYC3_Human0.99778085
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97480732
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97020669
64FOXO3_23340844_ChIP-Seq_DLD1_Human0.96322248
65* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95348585
66SA1_27219007_Chip-Seq_ERYTHROID_Human0.94694496
67SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93887520
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92512677
69SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92469562
70RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92078285
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91574564
72P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91189884
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90739468
74TP63_22573176_ChIP-Seq_HFKS_Human0.90329359
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90174977
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88327446
77SOX2_20726797_ChIP-Seq_SW620_Human0.87887430
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87204350
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86792889
80HTT_18923047_ChIP-ChIP_STHdh_Human0.86562799
81CDX2_20551321_ChIP-Seq_CACO-2_Human0.86395331
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.86061026
83ESR1_20079471_ChIP-ChIP_T-47D_Human0.85901116
84TET1_21451524_ChIP-Seq_MESCs_Mouse0.85849613
85* ELF1_20517297_ChIP-Seq_JURKAT_Human0.82874456
86ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82830806
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82136775
88TCF7_22412390_ChIP-Seq_EML_Mouse0.80610688
89LXR_22292898_ChIP-Seq_THP-1_Human0.78855048
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.78488158
91CJUN_26792858_Chip-Seq_BT549_Human0.77817947
92* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73539059
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72989483
94SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72389171
95RACK7_27058665_Chip-Seq_MCF-7_Human0.70419321
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.69058902
97P63_26484246_Chip-Seq_KERATINOCYTES_Human0.66854715
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65501691
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65411437
100GATA3_24758297_ChIP-Seq_MCF-7_Human0.63152841
101* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62958611
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62821105
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62537723
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.61183063
105GATA6_25053715_ChIP-Seq_YYC3_Human0.61131433
106* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.60657149
107EGR1_19032775_ChIP-ChIP_M12_Human0.60148898
108* TBX20_22080862_ChIP-Seq_HEART_Mouse0.60079957
109* TBX20_22328084_ChIP-Seq_HEART_Mouse0.60079957
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.59769605
111* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.59582661
112* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58581256
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.58005842
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57565131
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.57524034
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56246100
117GATA2_19941826_ChIP-Seq_K562_Human0.55581256
118BCAT_22108803_ChIP-Seq_LS180_Human0.54847045
119ELK3_25401928_ChIP-Seq_HUVEC_Human0.54707618
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.54526302
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.53986543
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.53864957
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.53864957
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.53507943
125RARA_24833708_ChIP-Seq_LIVER_Mouse0.53249608
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.52956893
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52778236
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.52397129
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51390753
130TP63_23658742_ChIP-Seq_EP156T_Human0.50809412
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.50475525
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.50183473
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.49876991
134GATA1_19941826_ChIP-Seq_K562_Human0.49829749
135CEBPB_22108803_ChIP-Seq_LS180_Human0.49735668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.52800815
2MP0005360_urolithiasis6.66472316
3MP0005085_abnormal_gallbladder_physiolo5.66258654
4MP0005365_abnormal_bile_salt5.56392239
5MP0008875_abnormal_xenobiotic_pharmacok5.03193592
6MP0003806_abnormal_nucleotide_metabolis3.85035461
7MP0003252_abnormal_bile_duct3.76803073
8MP0010329_abnormal_lipoprotein_level3.29306922
9MP0009840_abnormal_foam_cell3.19509507
10MP0005083_abnormal_biliary_tract2.76307192
11MP0005332_abnormal_amino_acid2.43924201
12MP0003195_calcinosis2.38916177
13MP0001666_abnormal_nutrient_absorption2.36427954
14MP0003191_abnormal_cellular_cholesterol2.31788863
15MP0003705_abnormal_hypodermis_morpholog2.28368538
16MP0002138_abnormal_hepatobiliary_system2.00407365
17MP0000609_abnormal_liver_physiology2.00093593
18MP0004019_abnormal_vitamin_homeostasis1.92604132
19MP0002118_abnormal_lipid_homeostasis1.91008190
20MP0005319_abnormal_enzyme/_coenzyme1.72122452
21MP0009780_abnormal_chondrocyte_physiolo1.67381613
22MP0008438_abnormal_cutaneous_collagen1.60698131
23MP0002254_reproductive_system_inflammat1.56882137
24MP0010368_abnormal_lymphatic_system1.48828848
25MP0003868_abnormal_feces_composition1.48308539
26MP0003186_abnormal_redox_activity1.47846512
27MP0002132_abnormal_respiratory_system1.39660755
28MP0005584_abnormal_enzyme/coenzyme_acti1.39232634
29MP0001764_abnormal_homeostasis1.29483026
30MP0009643_abnormal_urine_homeostasis1.27576529
31MP0002909_abnormal_adrenal_gland1.26578987
32MP0005375_adipose_tissue_phenotype1.19544055
33MP0003879_abnormal_hair_cell1.18826468
34MP0004858_abnormal_nervous_system1.17449062
35MP0003011_delayed_dark_adaptation1.12726331
36MP0009764_decreased_sensitivity_to1.10983392
37MP0000598_abnormal_liver_morphology1.10114864
38MP0000604_amyloidosis1.07265815
39MP0005275_abnormal_skin_tensile1.07018870
40MP0009697_abnormal_copulation1.06052434
41MP0004185_abnormal_adipocyte_glucose1.05113511
42MP0005451_abnormal_body_composition1.04912882
43MP0000566_synostosis1.04412738
44MP0009384_cardiac_valve_regurgitation1.03199070
45MP0003656_abnormal_erythrocyte_physiolo1.03066127
46MP0009763_increased_sensitivity_to1.02802867
47MP0005647_abnormal_sex_gland0.99862743
48MP0009053_abnormal_anal_canal0.99672988
49MP0005408_hypopigmentation0.99390456
50MP0002249_abnormal_larynx_morphology0.97223551
51MP0000751_myopathy0.87698681
52MP0001915_intracranial_hemorrhage0.87669196
53MP0005409_darkened_coat_color0.87471584
54MP0008469_abnormal_protein_level0.85369104
55MP0002060_abnormal_skin_morphology0.83754841
56MP0010234_abnormal_vibrissa_follicle0.81436514
57MP0002295_abnormal_pulmonary_circulatio0.80748437
58MP0000858_altered_metastatic_potential0.79946017
59MP0003300_gastrointestinal_ulcer0.79809993
60MP0005023_abnormal_wound_healing0.79325302
61MP0003724_increased_susceptibility_to0.79226263
62MP0003690_abnormal_glial_cell0.78620648
63MP0005165_increased_susceptibility_to0.77039465
64MP0005636_abnormal_mineral_homeostasis0.76751335
65MP0003279_aneurysm0.76029783
66MP0008004_abnormal_stomach_pH0.75653480
67MP0005084_abnormal_gallbladder_morpholo0.75635637
68MP0009642_abnormal_blood_homeostasis0.75630917
69MP0000003_abnormal_adipose_tissue0.74480737
70MP0005623_abnormal_meninges_morphology0.74176879
71MP0001756_abnormal_urination0.73878556
72MP0004130_abnormal_muscle_cell0.72656634
73MP0005670_abnormal_white_adipose0.71997885
74MP0005376_homeostasis/metabolism_phenot0.71828066
75MP0001849_ear_inflammation0.71567350
76MP0003091_abnormal_cell_migration0.70114962
77MP0003453_abnormal_keratinocyte_physiol0.69985598
78MP0006138_congestive_heart_failure0.69622497
79MP0009765_abnormal_xenobiotic_induced0.67999641
80MP0003172_abnormal_lysosome_physiology0.67682867
81MP0003329_amyloid_beta_deposits0.67454562
82MP0003436_decreased_susceptibility_to0.66813379
83MP0002168_other_aberrant_phenotype0.66811208
84MP0000678_abnormal_parathyroid_gland0.65737002
85MP0002896_abnormal_bone_mineralization0.65633593
86MP0002971_abnormal_brown_adipose0.64998924
87MP0005220_abnormal_exocrine_pancreas0.64705821
88MP0002136_abnormal_kidney_physiology0.62565158
89MP0005076_abnormal_cell_differentiation0.61500436
90MP0005164_abnormal_response_to0.61366532
91MP0003959_abnormal_lean_body0.61356225
92MP0002970_abnormal_white_adipose0.60730647
93MP0005334_abnormal_fat_pad0.60681517
94MP0002928_abnormal_bile_duct0.60271956
95MP0005257_abnormal_intraocular_pressure0.59627091
96MP0002078_abnormal_glucose_homeostasis0.58792519
97MP0000343_altered_response_to0.57993990
98MP0003566_abnormal_cell_adhesion0.57089507
99MP0008874_decreased_physiological_sensi0.55848230
100MP0004782_abnormal_surfactant_physiolog0.55131769
101MP0006082_CNS_inflammation0.55047290
102MP0003075_altered_response_to0.54746906
103MP0004883_abnormal_blood_vessel0.54086185
104MP0005464_abnormal_platelet_physiology0.53190309
105MP0002796_impaired_skin_barrier0.53176669
106MP0005166_decreased_susceptibility_to0.52966776
107MP0001243_abnormal_dermal_layer0.52129612
108MP0000639_abnormal_adrenal_gland0.51909829
109MP0005248_abnormal_Harderian_gland0.51629941
110MP0000249_abnormal_blood_vessel0.50680042
111MP0005395_other_phenotype0.50339487
112MP0005058_abnormal_lysosome_morphology0.48757195
113MP0002876_abnormal_thyroid_physiology0.47674230
114MP0002090_abnormal_vision0.47423432
115MP0001661_extended_life_span0.46020269
116MP0004947_skin_inflammation0.45789369
117MP0004272_abnormal_basement_membrane0.45425943
118MP0005266_abnormal_metabolism0.45302948
119MP0009115_abnormal_fat_cell0.44640520
120MP0001958_emphysema0.44066152
121MP0001533_abnormal_skeleton_physiology0.42454235
122MP0005666_abnormal_adipose_tissue0.42154247
123MP0005535_abnormal_body_temperature0.41982171
124MP0003638_abnormal_response/metabolism_0.40527063
125MP0005503_abnormal_tendon_morphology0.40352922
126MP0005448_abnormal_energy_balance0.40047452
127MP0001881_abnormal_mammary_gland0.39527210
128MP0008873_increased_physiological_sensi0.38915916
129MP0002135_abnormal_kidney_morphology0.38430873

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.34287528
2Intrahepatic cholestasis (HP:0001406)6.69904342
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.53854643
4Xanthomatosis (HP:0000991)6.15485963
5* Abnormality of monocarboxylic acid metabolism (HP:0010996)5.93683233
6Prolonged partial thromboplastin time (HP:0003645)5.82216654
7Hypobetalipoproteinemia (HP:0003563)5.77136897
8Complement deficiency (HP:0004431)5.31634879
9Hyperlipoproteinemia (HP:0010980)5.15690265
10Hypolipoproteinemia (HP:0010981)4.53419144
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.50655932
12Epidermoid cyst (HP:0200040)4.35451447
13Joint hemorrhage (HP:0005261)4.30773829
14Abnormality of the common coagulation pathway (HP:0010990)4.21935604
15Hyperammonemia (HP:0001987)4.16488969
16Hypoalphalipoproteinemia (HP:0003233)4.16426271
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14815253
18Abnormality of complement system (HP:0005339)4.03076201
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.02077652
20Abnormal respiratory epithelium morphology (HP:0012253)3.75561660
21Abnormal respiratory motile cilium morphology (HP:0005938)3.75561660
22Ketosis (HP:0001946)3.75281455
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.75076756
24Hyperglycinemia (HP:0002154)3.71344234
25Abnormal respiratory motile cilium physiology (HP:0012261)3.70028910
26* Fat malabsorption (HP:0002630)3.63357776
27Abnormality of methionine metabolism (HP:0010901)3.62207284
28Abnormality of the intrinsic pathway (HP:0010989)3.58899986
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.55649357
30Abnormal ciliary motility (HP:0012262)3.55319111
31Rhinitis (HP:0012384)3.53450711
32Hypoglycemic coma (HP:0001325)3.53393690
33Hyperglycinuria (HP:0003108)3.50844182
34Absent/shortened dynein arms (HP:0200106)3.48064593
35Dynein arm defect of respiratory motile cilia (HP:0012255)3.48064593
36Myocardial infarction (HP:0001658)3.47660780
37Abnormality of glycine metabolism (HP:0010895)3.45243355
38Abnormality of serine family amino acid metabolism (HP:0010894)3.45243355
39Hypercholesterolemia (HP:0003124)3.40267026
40Conjugated hyperbilirubinemia (HP:0002908)3.18698128
41Abnormality of fatty-acid metabolism (HP:0004359)3.12242826
42Abnormality of pyrimidine metabolism (HP:0004353)3.08012704
43Systemic lupus erythematosus (HP:0002725)3.02377087
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.96629015
45Hepatocellular carcinoma (HP:0001402)2.94164420
46Nasal polyposis (HP:0100582)2.89287438
47Chronic bronchitis (HP:0004469)2.88708428
48Mitral stenosis (HP:0001718)2.87186548
49Hyperbilirubinemia (HP:0002904)2.86552701
50Skin nodule (HP:0200036)2.78820015
51Abnormality of the nasal mucosa (HP:0000433)2.77030523
52Abnormality of nucleobase metabolism (HP:0010932)2.73974320
53Vascular calcification (HP:0004934)2.73737322
54Ketoacidosis (HP:0001993)2.72655898
55Cardiovascular calcification (HP:0011915)2.67342012
56Delayed CNS myelination (HP:0002188)2.63047121
57Esophageal varix (HP:0002040)2.61563143
58Spastic diplegia (HP:0001264)2.60255965
59Purpura (HP:0000979)2.59082768
60Abnormality of purine metabolism (HP:0004352)2.56955128
61Spontaneous abortion (HP:0005268)2.56291430
62* Steatorrhea (HP:0002570)2.56124679
63Abnormality of serum amino acid levels (HP:0003112)2.51377133
64Glomerulonephritis (HP:0000099)2.49643455
65Amyloidosis (HP:0011034)2.38894209
66Vertebral compression fractures (HP:0002953)2.36704117
67Metabolic acidosis (HP:0001942)2.36269230
68Recurrent gram-negative bacterial infections (HP:0005420)2.33264851
69Neonatal onset (HP:0003623)2.32092065
70Mucopolysacchariduria (HP:0008155)2.30923314
71Urinary glycosaminoglycan excretion (HP:0003541)2.30923314
72Bronchiectasis (HP:0002110)2.30838220
73Gout (HP:0001997)2.29952148
74Abnormal gallbladder morphology (HP:0012437)2.29850854
75Neurofibrillary tangles (HP:0002185)2.29695156
76Abnormal gallbladder physiology (HP:0012438)2.28899291
77Cholecystitis (HP:0001082)2.28899291
78Cholelithiasis (HP:0001081)2.27170774
79Hypochromic microcytic anemia (HP:0004840)2.26374740
80Nephritis (HP:0000123)2.26078742
81Hemorrhage of the eye (HP:0011885)2.25343780
82Malnutrition (HP:0004395)2.24322954
83Abnormal cartilage morphology (HP:0002763)2.23961538
84Peritonitis (HP:0002586)2.19288025
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18303480
86Abnormality of polysaccharide metabolism (HP:0011012)2.18303480
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18303480
88Dicarboxylic aciduria (HP:0003215)2.16448507
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16448507
90Hydroxyprolinuria (HP:0003080)2.12391497
91Abnormality of proline metabolism (HP:0010907)2.12391497
92Lethargy (HP:0001254)2.12092963
93Sensorimotor neuropathy (HP:0007141)2.10756691
94Gingival bleeding (HP:0000225)2.08821908
95Cerebral inclusion bodies (HP:0100314)2.08318020
96Acanthocytosis (HP:0001927)2.06018639
97Hypoglycemic seizures (HP:0002173)2.03414779
98Protrusio acetabuli (HP:0003179)2.03309140
99Irritability (HP:0000737)2.02388198
100Menorrhagia (HP:0000132)1.99448158
101Polycythemia (HP:0001901)1.97850747
102Obstructive sleep apnea (HP:0002870)1.96513616
103Pancreatitis (HP:0001733)1.95130003
104Opisthotonus (HP:0002179)1.93477746
105Atelectasis (HP:0100750)1.92361877
106Dysostosis multiplex (HP:0000943)1.91590520
107Thrombophlebitis (HP:0004418)1.89085135
108Abnormality of iron homeostasis (HP:0011031)1.87955953
109Abnormality of the gallbladder (HP:0005264)1.87669593
110Abnormality of transition element cation homeostasis (HP:0011030)1.86767158
111Hypophosphatemic rickets (HP:0004912)1.83070158
112Nuclear cataract (HP:0100018)1.83035849
113Distal lower limb muscle weakness (HP:0009053)1.82799007
114Abnormal enzyme/coenzyme activity (HP:0012379)1.82243858
115Atrioventricular block (HP:0001678)1.82123570
116Late onset (HP:0003584)1.81437586
117Flat acetabular roof (HP:0003180)1.80659177
118Turricephaly (HP:0000262)1.79377344
119* Rickets (HP:0002748)1.78701590
120Back pain (HP:0003418)1.78683881
121Cervical subluxation (HP:0003308)1.78384433
122Generalized aminoaciduria (HP:0002909)1.78074275
123Abnormality of carpal bone ossification (HP:0006257)1.77386968
124Abnormality of the Achilles tendon (HP:0005109)1.76626959
125Vomiting (HP:0002013)1.76316424
126Stroke (HP:0001297)1.76245942
127Increased mean platelet volume (HP:0011877)1.76241083
128Male infertility (HP:0003251)1.73970472
129Right ventricular cardiomyopathy (HP:0011663)1.73149965
130Infertility (HP:0000789)1.73019804
131Ectopia lentis (HP:0001083)1.71774990
132Achilles tendon contracture (HP:0001771)1.70438914
133Hypertriglyceridemia (HP:0002155)1.70325054
134Premature rupture of membranes (HP:0001788)1.68932665
135Abnormality of glycolipid metabolism (HP:0010969)1.68387317
136Abnormality of liposaccharide metabolism (HP:0010968)1.68387317
137Abnormality of glycosphingolipid metabolism (HP:0004343)1.68387317
138Elevated alkaline phosphatase (HP:0003155)1.68307158
139Recurrent otitis media (HP:0000403)1.66669232
140Polygenic inheritance (HP:0010982)1.64437412
141Short nail (HP:0001799)1.63889735
142Interstitial pulmonary disease (HP:0006530)1.62761038
143Increased serum ferritin (HP:0003281)1.62752547
144Neonatal hypoglycemia (HP:0001998)1.60436566
145Renal salt wasting (HP:0000127)1.58510113
146Acanthosis nigricans (HP:0000956)1.58107550
147Vascular tortuosity (HP:0004948)1.54517451
148Upper limb amyotrophy (HP:0009129)1.53405070
149Distal upper limb amyotrophy (HP:0007149)1.53405070
150Osteomalacia (HP:0002749)1.53064036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.56140366
2ERN14.46093510
3FGFR44.04707986
4SIK14.00205102
5TRIB32.76121858
6ICK2.71624409
7SMG12.40413668
8PKN22.33311477
9ERBB42.26835243
10EEF2K2.19342846
11PRPF4B2.10629105
12MST1R2.10406463
13LATS12.02299128
14IRAK31.94275977
15TESK11.85838712
16PRKD31.78816756
17EPHA31.73579608
18FRK1.73522277
19RIPK11.73487474
20MAPKAPK31.73237738
21EPHB11.66107559
22MAP3K31.64100428
23PTK61.63492829
24INSRR1.57102726
25NEK91.56557655
26KDR1.50105633
27TAOK31.50050973
28EPHB21.49775450
29TYK21.49771983
30TBK11.45167688
31MAP2K31.44611485
32JAK11.41682409
33TGFBR21.36284804
34PIK3CG1.30343546
35TTN1.23655397
36FGFR21.22816581
37MAP2K41.21884378
38CDC42BPA1.20052906
39MAP3K141.17313759
40EPHA21.16842199
41LMTK21.16143036
42MAPK111.11151833
43FLT31.11111286
44PDGFRA1.10880970
45CDK121.05366983
46ABL21.05282636
47AKT31.02995821
48MARK21.02786539
49NTRK11.02224802
50DYRK1B1.02120033
51STK381.01673106
52PAK41.01532729
53ARAF1.00926668
54PTK20.99827581
55FER0.99406229
56TIE10.98159450
57CDK60.98000234
58MET0.97854980
59JAK20.97139299
60PAK30.95925567
61FGFR30.91133728
62IKBKE0.89483346
63MAPK150.89161595
64CAMK1G0.87274047
65MAP3K70.87112410
66MAP2K10.85891812
67DDR20.85776388
68LRRK20.85191240
69BMX0.83312797
70MAP3K130.82865441
71PRKD20.80071839
72ERBB20.78894039
73DAPK20.77099830
74MAP3K60.74756599
75CSK0.74484638
76MAP3K110.71167923
77STK38L0.71028948
78MYLK0.70053810
79GSK3A0.69026994
80KSR20.68657300
81LATS20.68565191
82TAOK10.67146928
83MAP3K20.66984617
84CAMKK10.65285236
85MAPK120.63332345
86PRKAA20.61801521
87GRK60.60952339
88RET0.60199860
89PDK20.59903334
90RPS6KA40.59766687
91PIM20.59275529
92CHUK0.59005828
93PRKCZ0.58890380
94FGFR10.58279568
95PDK10.57597546
96MAP2K20.55334497
97ZAP700.54440092
98PAK20.54095132
99RPS6KA20.53047383
100CAMK1D0.52855070
101MTOR0.52771479
102HIPK20.51376598
103IGF1R0.51207939
104MAPK40.49399786
105MAP3K100.48559748
106CAMK2G0.47504783
107MAP2K60.46524724
108IKBKB0.45815394
109JAK30.45464199
110PRKAA10.45017736
111PDK30.44770189
112PDK40.44770189
113SCYL20.44294791
114PRKCH0.42945069
115PRKD10.42347075
116PINK10.41505258
117AKT20.41315387
118PDPK10.41014079
119NLK0.40996705
120PBK0.40804497
121SGK30.40648642
122MAPK70.40506930
123MAP3K10.39647186
124PDGFRB0.39583816
125EGFR0.39398289
126TRPM70.39138158
127PIK3CA0.38299225
128PRKACG0.38248341
129STK30.38112699
130ABL10.37939824
131TAOK20.37773924
132CDK90.36902400
133NEK60.35291770
134SRC0.33230703
135LIMK10.31182666
136ILK0.29700835
137NTRK30.27851761
138MELK0.26386365

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32671150
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.58248951
3Nitrogen metabolism_Homo sapiens_hsa009103.32896786
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.03477317
5Arginine biosynthesis_Homo sapiens_hsa002202.78795718
6Complement and coagulation cascades_Homo sapiens_hsa046102.75379228
7Tryptophan metabolism_Homo sapiens_hsa003802.63493121
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.62015842
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.59686557
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58409063
11Fatty acid degradation_Homo sapiens_hsa000712.51070731
12* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.34267943
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33728227
14* Chemical carcinogenesis_Homo sapiens_hsa052042.29790477
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27408161
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24322449
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.11118304
18Peroxisome_Homo sapiens_hsa041461.95040310
19Butanoate metabolism_Homo sapiens_hsa006501.93556227
20Caffeine metabolism_Homo sapiens_hsa002321.93489056
21PPAR signaling pathway_Homo sapiens_hsa033201.92918600
22Histidine metabolism_Homo sapiens_hsa003401.86155800
23Retinol metabolism_Homo sapiens_hsa008301.81402837
24Fatty acid metabolism_Homo sapiens_hsa012121.80894261
25Propanoate metabolism_Homo sapiens_hsa006401.77360465
26Staphylococcus aureus infection_Homo sapiens_hsa051501.75878193
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.68901333
28beta-Alanine metabolism_Homo sapiens_hsa004101.66750653
29Phenylalanine metabolism_Homo sapiens_hsa003601.54051719
30Sulfur metabolism_Homo sapiens_hsa009201.51332961
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49287368
32Tyrosine metabolism_Homo sapiens_hsa003501.46635270
33* Bile secretion_Homo sapiens_hsa049761.43913412
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42347072
35Selenocompound metabolism_Homo sapiens_hsa004501.41369890
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39267964
37Starch and sucrose metabolism_Homo sapiens_hsa005001.39194718
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32948456
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25644878
40Pyruvate metabolism_Homo sapiens_hsa006201.23564889
41ABC transporters_Homo sapiens_hsa020101.17880199
42Fatty acid elongation_Homo sapiens_hsa000621.14755768
43Fat digestion and absorption_Homo sapiens_hsa049751.12675428
44Steroid biosynthesis_Homo sapiens_hsa001001.10609584
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.08840461
46Sulfur relay system_Homo sapiens_hsa041221.02097487
47Glutathione metabolism_Homo sapiens_hsa004801.00498913
48Carbon metabolism_Homo sapiens_hsa012001.00319158
49Biosynthesis of amino acids_Homo sapiens_hsa012300.99240312
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98956195
51Folate biosynthesis_Homo sapiens_hsa007900.97904074
52Other glycan degradation_Homo sapiens_hsa005110.97340132
53Arachidonic acid metabolism_Homo sapiens_hsa005900.85756344
54Arginine and proline metabolism_Homo sapiens_hsa003300.85244927
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84588806
56Vitamin digestion and absorption_Homo sapiens_hsa049770.84039928
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82158165
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.81559742
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80281768
60Vitamin B6 metabolism_Homo sapiens_hsa007500.77392532
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.70546791
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69094593
63Lysine degradation_Homo sapiens_hsa003100.68662080
64Glycerolipid metabolism_Homo sapiens_hsa005610.64196849
65Fatty acid biosynthesis_Homo sapiens_hsa000610.59399076
66Pentose phosphate pathway_Homo sapiens_hsa000300.52645736
67Prion diseases_Homo sapiens_hsa050200.51931278
68One carbon pool by folate_Homo sapiens_hsa006700.41863441
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40574717
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.37773290
71Insulin resistance_Homo sapiens_hsa049310.34855954
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33670184
73Metabolic pathways_Homo sapiens_hsa011000.32062161
74Sphingolipid metabolism_Homo sapiens_hsa006000.29479873
75Galactose metabolism_Homo sapiens_hsa000520.27131827
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23757818
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17263055
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15824812
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.11747936
80Amoebiasis_Homo sapiens_hsa051460.10726179
81Fructose and mannose metabolism_Homo sapiens_hsa000510.09454524
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09074586
83Bladder cancer_Homo sapiens_hsa052190.07960437
84Linoleic acid metabolism_Homo sapiens_hsa005910.07940858
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.07265599
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06329905
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05225509
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.05217151
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05214493
90Notch signaling pathway_Homo sapiens_hsa043300.04487820
91ECM-receptor interaction_Homo sapiens_hsa045120.03586717
92AMPK signaling pathway_Homo sapiens_hsa041520.02494720
93Malaria_Homo sapiens_hsa051440.01775451
94Glucagon signaling pathway_Homo sapiens_hsa049220.01753036
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01585663
96Tight junction_Homo sapiens_hsa045300.01213137
97Vibrio cholerae infection_Homo sapiens_hsa051100.00898443
98Renin-angiotensin system_Homo sapiens_hsa04614-0.1431100
99Proteoglycans in cancer_Homo sapiens_hsa05205-0.1392480
100Focal adhesion_Homo sapiens_hsa04510-0.1346899
101Protein digestion and absorption_Homo sapiens_hsa04974-0.1126297
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1119605
103Mineral absorption_Homo sapiens_hsa04978-0.1117057
104Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1061695
105Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0938636
106Insulin signaling pathway_Homo sapiens_hsa04910-0.0858501
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0829382
108Lysosome_Homo sapiens_hsa04142-0.0679727
109African trypanosomiasis_Homo sapiens_hsa05143-0.0509619
110Hepatitis C_Homo sapiens_hsa05160-0.0336562
111Circadian rhythm_Homo sapiens_hsa04710-0.0274581
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0049983
113Pertussis_Homo sapiens_hsa05133-0.0003978

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