EPHB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.12411510
2fatty acid elongation (GO:0030497)6.91262797
3myelination (GO:0042552)5.98067267
4axon ensheathment (GO:0008366)5.94550617
5ensheathment of neurons (GO:0007272)5.94550617
6postsynaptic membrane organization (GO:0001941)5.90166695
7nucleobase catabolic process (GO:0046113)5.50870601
8long-chain fatty acid biosynthetic process (GO:0042759)5.49301280
9L-amino acid import (GO:0043092)4.77856954
10cholesterol biosynthetic process (GO:0006695)4.74055584
11neurotransmitter-gated ion channel clustering (GO:0072578)4.60213009
12negative regulation of neurotransmitter transport (GO:0051589)4.42974617
13establishment of mitochondrion localization (GO:0051654)4.42587825
14negative regulation of neurotransmitter secretion (GO:0046929)4.41693305
15myelin maintenance (GO:0043217)4.32750130
16negative regulation of protein localization to cell surface (GO:2000009)4.31188149
17regulation of collateral sprouting (GO:0048670)4.25405157
18sterol biosynthetic process (GO:0016126)4.16831567
19presynaptic membrane organization (GO:0097090)4.16279152
20response to methylmercury (GO:0051597)4.15276992
21neuron cell-cell adhesion (GO:0007158)4.12781452
22glycerophospholipid catabolic process (GO:0046475)3.95807592
23presynaptic membrane assembly (GO:0097105)3.95118624
24vocalization behavior (GO:0071625)3.92497600
25oligodendrocyte differentiation (GO:0048709)3.86847215
26response to auditory stimulus (GO:0010996)3.86780821
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.86370048
28photoreceptor cell differentiation (GO:0046530)3.82136275
29eye photoreceptor cell differentiation (GO:0001754)3.82136275
30isoprenoid biosynthetic process (GO:0008299)3.76511297
31transmission of nerve impulse (GO:0019226)3.75107402
32amino acid import (GO:0043090)3.67316822
33nonmotile primary cilium assembly (GO:0035058)3.64683361
34substantia nigra development (GO:0021762)3.60545546
35olfactory bulb development (GO:0021772)3.57982151
36cerebral cortex radially oriented cell migration (GO:0021799)3.54527271
37long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.54083027
38apical protein localization (GO:0045176)3.50780347
39synapse assembly (GO:0007416)3.49128206
40regulation of short-term neuronal synaptic plasticity (GO:0048172)3.48316839
41* positive regulation of synapse assembly (GO:0051965)3.45409053
42neuronal action potential propagation (GO:0019227)3.45255651
43* central nervous system projection neuron axonogenesis (GO:0021952)3.43113696
44adult walking behavior (GO:0007628)3.41455316
45neuronal ion channel clustering (GO:0045161)3.41262203
46negative regulation of oligodendrocyte differentiation (GO:0048715)3.39327584
47regulation of synaptic vesicle exocytosis (GO:2000300)3.39248093
48astrocyte development (GO:0014002)3.37448057
49behavioral response to nicotine (GO:0035095)3.36955422
50asymmetric protein localization (GO:0008105)3.35874279
51negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.35263178
52negative regulation of axonogenesis (GO:0050771)3.33985196
53neuron recognition (GO:0008038)3.33092783
54long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.32763062
55synaptic vesicle endocytosis (GO:0048488)3.32539042
56establishment of nucleus localization (GO:0040023)3.32179099
57limb bud formation (GO:0060174)3.31621946
58import into cell (GO:0098657)3.30292873
59* retinal ganglion cell axon guidance (GO:0031290)3.30097177
60cell migration in hindbrain (GO:0021535)3.29575515
61synaptic transmission, glutamatergic (GO:0035249)3.29365862
62neuronal stem cell maintenance (GO:0097150)3.28896501
63positive regulation of oligodendrocyte differentiation (GO:0048714)3.28869653
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.27813910
65myelination in peripheral nervous system (GO:0022011)3.26071745
66peripheral nervous system axon ensheathment (GO:0032292)3.26071745
67membrane tubulation (GO:0097320)3.25552792
68exploration behavior (GO:0035640)3.24698551
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20477031
70neuron remodeling (GO:0016322)3.20170414
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19869226
72negative regulation of axon extension (GO:0030517)3.19491774
73axon extension (GO:0048675)3.14651652
74axon extension involved in axon guidance (GO:0048846)3.14554362
75neuron projection extension involved in neuron projection guidance (GO:1902284)3.14554362
76negative regulation of axon guidance (GO:1902668)3.13842322
77regulation of synapse structural plasticity (GO:0051823)3.13791738
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.13725671
79amyloid precursor protein metabolic process (GO:0042982)3.13354085
80response to redox state (GO:0051775)3.12496980
81positive regulation of mitochondrial fission (GO:0090141)3.12262534
82forebrain neuron differentiation (GO:0021879)3.10816396
83creatine metabolic process (GO:0006600)3.09972968
84spinal cord development (GO:0021510)3.08994353
85axonal fasciculation (GO:0007413)3.08543459
86peptidyl-tyrosine autophosphorylation (GO:0038083)3.07965412
87* dendritic spine morphogenesis (GO:0060997)3.07657159
88fatty-acyl-CoA biosynthetic process (GO:0046949)3.01580127
89regulation of synaptic vesicle transport (GO:1902803)3.00466031
90neurofilament cytoskeleton organization (GO:0060052)2.98239108
91synapse organization (GO:0050808)2.96710478
92cerebral cortex neuron differentiation (GO:0021895)2.95941974
93response to lipoprotein particle (GO:0055094)2.94465759
94hippocampus development (GO:0021766)2.92514922
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90702896
96neurotransmitter uptake (GO:0001504)2.90624560
97dendrite morphogenesis (GO:0048813)2.88889028
98calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.88018021
99regulation of respiratory system process (GO:0044065)2.86696786
100cerebellar granule cell differentiation (GO:0021707)2.85791629
101acidic amino acid transport (GO:0015800)2.85560216
102nerve growth factor signaling pathway (GO:0038180)2.85296761
103dendrite development (GO:0016358)2.85038103
104protein palmitoylation (GO:0018345)2.84155265
105neuron-neuron synaptic transmission (GO:0007270)2.84067990
106magnesium ion transport (GO:0015693)2.84008498
107neuron migration (GO:0001764)2.82260144
108fatty-acyl-CoA metabolic process (GO:0035337)2.80237131
109* central nervous system neuron axonogenesis (GO:0021955)2.79742574
110regulation of axon guidance (GO:1902667)2.78194200
111protein polyglutamylation (GO:0018095)2.76940617
112regulation of oligodendrocyte differentiation (GO:0048713)2.76864979
113neuron projection extension (GO:1990138)2.76093070
114glutamate secretion (GO:0014047)2.75625006
115startle response (GO:0001964)2.75277029
116glycosphingolipid biosynthetic process (GO:0006688)2.72201869
117positive regulation of action potential (GO:0045760)2.71640941
118neuromuscular synaptic transmission (GO:0007274)2.71556251
119epithelial cilium movement (GO:0003351)2.70859270
120positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.70104486
121* regulation of synapse assembly (GO:0051963)2.69615783
122neurotransmitter secretion (GO:0007269)2.68975172
123ionotropic glutamate receptor signaling pathway (GO:0035235)2.68947373
124spinal cord association neuron differentiation (GO:0021527)2.68807573
125cilium movement (GO:0003341)2.67020057
126locomotory exploration behavior (GO:0035641)2.66021862
127axon development (GO:0061564)2.65726677
128very long-chain fatty acid metabolic process (GO:0000038)2.65279446
129auditory behavior (GO:0031223)2.63838614
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63706281
131mitochondrion transport along microtubule (GO:0047497)2.63706281
132neural nucleus development (GO:0048857)2.60154885
133peripheral nervous system development (GO:0007422)2.59402163
134cellular response to epinephrine stimulus (GO:0071872)2.57096785
135substrate-independent telencephalic tangential migration (GO:0021826)2.55304950
136substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.55304950
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55014918
138gamma-aminobutyric acid signaling pathway (GO:0007214)2.54157096
139synaptic vesicle maturation (GO:0016188)2.53354506
140glutamate receptor signaling pathway (GO:0007215)2.52658210
141mechanosensory behavior (GO:0007638)2.52071940
142regulation of lipoprotein metabolic process (GO:0050746)2.49557481
143lateral sprouting from an epithelium (GO:0060601)2.48887922
144positive regulation of neurological system process (GO:0031646)2.48362774
145C4-dicarboxylate transport (GO:0015740)2.48028393
146regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47741675
147cellular response to catecholamine stimulus (GO:0071870)2.44294878
148cellular response to monoamine stimulus (GO:0071868)2.44294878
149organ growth (GO:0035265)2.43697175
150gamma-aminobutyric acid transport (GO:0015812)2.41894191
151glial cell differentiation (GO:0010001)2.41868100
152adult locomotory behavior (GO:0008344)2.41172606
153protein localization to synapse (GO:0035418)2.40194142
154acyl-CoA biosynthetic process (GO:0071616)2.39903359
155thioester biosynthetic process (GO:0035384)2.39903359
156mating behavior (GO:0007617)2.39176908
157negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38927478
158regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.38681032
159layer formation in cerebral cortex (GO:0021819)2.38528057
160synaptic vesicle exocytosis (GO:0016079)2.37900228
161axon ensheathment in central nervous system (GO:0032291)10.2794981
162central nervous system myelination (GO:0022010)10.2794981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.30445866
2GBX2_23144817_ChIP-Seq_PC3_Human3.43048898
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72172358
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65719700
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64367621
6IGF1R_20145208_ChIP-Seq_DFB_Human2.48305954
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.45275134
8* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.31709119
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31004186
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31004186
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29777295
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29648942
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23919338
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20376851
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18230784
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.17955050
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14577140
18* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14396618
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14073233
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.11525201
21TAF15_26573619_Chip-Seq_HEK293_Human2.11206809
22AR_21572438_ChIP-Seq_LNCaP_Human2.08849205
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07825708
24ZNF274_21170338_ChIP-Seq_K562_Hela2.02725070
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.02273159
26DROSHA_22980978_ChIP-Seq_HELA_Human1.98873741
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92340915
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88968430
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.85778331
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78701725
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75026853
32* REST_21632747_ChIP-Seq_MESCs_Mouse1.66802968
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65744770
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.64068658
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63996366
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63241365
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61637198
38ER_23166858_ChIP-Seq_MCF-7_Human1.60927866
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58293489
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56414955
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55181721
42* SMAD3_21741376_ChIP-Seq_EPCs_Human1.55049546
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53276104
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44093610
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41800539
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40512709
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39555006
48VDR_22108803_ChIP-Seq_LS180_Human1.37902004
49P300_19829295_ChIP-Seq_ESCs_Human1.36706383
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35493817
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.35234304
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.33691176
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32864321
54* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29904269
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25709468
56* AR_25329375_ChIP-Seq_VCAP_Human1.24830946
57IRF1_19129219_ChIP-ChIP_H3396_Human1.24659486
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23503104
59FUS_26573619_Chip-Seq_HEK293_Human1.23307406
60* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22709059
61RNF2_27304074_Chip-Seq_NSC_Mouse1.22033433
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21408988
63STAT3_23295773_ChIP-Seq_U87_Human1.21062648
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20873257
65* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20216310
66EWS_26573619_Chip-Seq_HEK293_Human1.20021907
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18734741
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18139425
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17363144
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17340150
71* SMAD4_21799915_ChIP-Seq_A2780_Human1.16570119
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.15352465
73* RING1B_27294783_Chip-Seq_NPCs_Mouse1.14475956
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14203702
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11273612
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11140573
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11068136
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10048071
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09879215
80JUN_21703547_ChIP-Seq_K562_Human1.09049377
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07629766
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07118814
83* AR_19668381_ChIP-Seq_PC3_Human1.07082463
84CBP_20019798_ChIP-Seq_JUKART_Human1.06072869
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06072869
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.05032099
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.04916433
88* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04160438
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03956954
90* TCF4_23295773_ChIP-Seq_U87_Human1.03914857
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.03900279
92* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03771741
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.03622423
94AHR_22903824_ChIP-Seq_MCF-7_Human1.02756883
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.02560347
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.01436768
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00570539
98* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99655001
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99018721
100TP53_16413492_ChIP-PET_HCT116_Human0.98646668
101SOX9_26525672_Chip-Seq_HEART_Mouse0.97977340
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97910693
103ERG_21242973_ChIP-ChIP_JURKAT_Human0.97791939
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97188177
105* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97000150
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96687017
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96619546
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96619546
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96403803
110NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96403803
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.96048871
112LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95625639
113NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94631861
114TAL1_26923725_Chip-Seq_HPCs_Mouse0.94455992
115* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94321244
116* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94073160
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93673728
118SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93281806
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92151538
120P300_18555785_Chip-Seq_ESCs_Mouse0.89396787
121GATA1_26923725_Chip-Seq_HPCs_Mouse0.88164299
122* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87406431
123E2F1_18555785_Chip-Seq_ESCs_Mouse0.87001744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.42015581
2MP0000920_abnormal_myelination4.28272240
3MP0004270_analgesia3.39074043
4MP0004859_abnormal_synaptic_plasticity3.22005309
5MP0001486_abnormal_startle_reflex2.92779621
6MP0001529_abnormal_vocalization2.87273933
7MP0005423_abnormal_somatic_nervous2.79395256
8MP0003122_maternal_imprinting2.77977349
9MP0002272_abnormal_nervous_system2.62543611
10MP0003690_abnormal_glial_cell2.60181281
11MP0004742_abnormal_vestibular_system2.58564395
12MP0003635_abnormal_synaptic_transmissio2.54258725
13MP0002064_seizures2.52400617
14MP0002653_abnormal_ependyma_morphology2.51376005
15MP0004885_abnormal_endolymph2.50868390
16* MP0000778_abnormal_nervous_system2.46166958
17MP0003329_amyloid_beta_deposits2.45375461
18MP0001485_abnormal_pinna_reflex2.37470751
19MP0009745_abnormal_behavioral_response2.33342521
20MP0001905_abnormal_dopamine_level2.20213459
21MP0003136_yellow_coat_color2.16705084
22MP0009046_muscle_twitch2.15257873
23MP0005171_absent_coat_pigmentation2.15115770
24MP0005409_darkened_coat_color2.14783820
25MP0003950_abnormal_plasma_membrane2.13344587
26MP0003121_genomic_imprinting2.11196993
27MP0003787_abnormal_imprinting2.09522961
28MP0004142_abnormal_muscle_tone2.05817473
29MP0002063_abnormal_learning/memory/cond2.03631637
30MP0003634_abnormal_glial_cell1.99352835
31MP0002734_abnormal_mechanical_nocicepti1.98998392
32MP0002572_abnormal_emotion/affect_behav1.95156425
33MP0005499_abnormal_olfactory_system1.79787815
34MP0005394_taste/olfaction_phenotype1.79787815
35MP0002638_abnormal_pupillary_reflex1.72991790
36MP0001440_abnormal_grooming_behavior1.68287427
37MP0003632_abnormal_nervous_system1.67145446
38MP0008877_abnormal_DNA_methylation1.62329568
39MP0002229_neurodegeneration1.62293656
40MP0000955_abnormal_spinal_cord1.59684422
41* MP0002882_abnormal_neuron_morphology1.54447960
42MP0002067_abnormal_sensory_capabilities1.52590461
43MP0005386_behavior/neurological_phenoty1.50390476
44MP0004924_abnormal_behavior1.50390476
45MP0002822_catalepsy1.46725524
46MP0008569_lethality_at_weaning1.45729259
47MP0000462_abnormal_digestive_system1.45152637
48MP0004134_abnormal_chest_morphology1.45114643
49MP0005551_abnormal_eye_electrophysiolog1.45006524
50MP0001970_abnormal_pain_threshold1.44052029
51MP0001968_abnormal_touch/_nociception1.41911840
52MP0002066_abnormal_motor_capabilities/c1.40587245
53MP0008789_abnormal_olfactory_epithelium1.38429553
54MP0003631_nervous_system_phenotype1.37731339
55MP0005410_abnormal_fertilization1.37029168
56MP0002733_abnormal_thermal_nociception1.36018003
57MP0001963_abnormal_hearing_physiology1.35824448
58MP0002751_abnormal_autonomic_nervous1.34942489
59MP0003011_delayed_dark_adaptation1.29557148
60MP0002184_abnormal_innervation1.25595650
61MP0006292_abnormal_olfactory_placode1.24296143
62* MP0002752_abnormal_somatic_nervous1.23657951
63MP0003890_abnormal_embryonic-extraembry1.23492613
64MP0000566_synostosis1.22848659
65MP0010678_abnormal_skin_adnexa1.22591465
66MP0003633_abnormal_nervous_system1.22139060
67MP0005623_abnormal_meninges_morphology1.19567562
68MP0001299_abnormal_eye_distance/1.19322012
69MP0002735_abnormal_chemical_nociception1.17402298
70MP0002557_abnormal_social/conspecific_i1.17102682
71MP0000569_abnormal_digit_pigmentation1.16480278
72MP0005187_abnormal_penis_morphology1.16047792
73MP0000604_amyloidosis1.11828217
74* MP0002152_abnormal_brain_morphology1.09880131
75MP0004145_abnormal_muscle_electrophysio1.07720131
76MP0003938_abnormal_ear_development1.07629007
77MP0000383_abnormal_hair_follicle1.07452802
78MP0001177_atelectasis1.06080514
79MP0000026_abnormal_inner_ear1.05574987
80MP0004043_abnormal_pH_regulation1.04080786
81MP0000049_abnormal_middle_ear1.01997541
82MP0004858_abnormal_nervous_system1.01614494
83MP0001502_abnormal_circadian_rhythm1.01611308
84MP0002736_abnormal_nociception_after1.01595372
85MP0006276_abnormal_autonomic_nervous1.00713828
86MP0004381_abnormal_hair_follicle0.99473257
87MP0002909_abnormal_adrenal_gland0.98835437
88MP0001986_abnormal_taste_sensitivity0.98346327
89MP0002928_abnormal_bile_duct0.94549876
90MP0003137_abnormal_impulse_conducting0.94524493
91* MP0005195_abnormal_posterior_eye0.93956366
92MP0005645_abnormal_hypothalamus_physiol0.93769531
93MP0004811_abnormal_neuron_physiology0.93538063
94MP0000631_abnormal_neuroendocrine_gland0.89410365
95MP0001346_abnormal_lacrimal_gland0.89327798
96MP0006072_abnormal_retinal_apoptosis0.88750265
97MP0002102_abnormal_ear_morphology0.87753314
98MP0000647_abnormal_sebaceous_gland0.84469176
99MP0003221_abnormal_cardiomyocyte_apopto0.82578299
100MP0001501_abnormal_sleep_pattern0.81964016
101MP0005646_abnormal_pituitary_gland0.80875251
102MP0002069_abnormal_eating/drinking_beha0.80450840
103MP0001293_anophthalmia0.80351673
104MP0000747_muscle_weakness0.79328215
105* MP0005391_vision/eye_phenotype0.78901191
106MP0005253_abnormal_eye_physiology0.78857086
107MP0005451_abnormal_body_composition0.78247964
108MP0005167_abnormal_blood-brain_barrier0.76868767
109MP0001188_hyperpigmentation0.76602085
110MP0008260_abnormal_autophagy0.76601985
111MP0005248_abnormal_Harderian_gland0.76000159
112MP0003119_abnormal_digestive_system0.75818844
113MP0000762_abnormal_tongue_morphology0.74694239
114MP0003937_abnormal_limbs/digits/tail_de0.74305736
115MP0001984_abnormal_olfaction0.73388104
116MP0002090_abnormal_vision0.71959823
117MP0003878_abnormal_ear_physiology0.71616587
118MP0005377_hearing/vestibular/ear_phenot0.71616587
119MP0002938_white_spotting0.71484904
120* MP0003861_abnormal_nervous_system0.70864918
121MP0002295_abnormal_pulmonary_circulatio0.70378521
122MP0004133_heterotaxia0.68757877
123MP0000579_abnormal_nail_morphology0.68494687
124MP0002233_abnormal_nose_morphology0.68430410
125MP0004147_increased_porphyrin_level0.66120320
126MP0009780_abnormal_chondrocyte_physiolo0.66002847
127MP0009250_abnormal_appendicular_skeleto0.65672708
128MP0001919_abnormal_reproductive_system0.65475681
129MP0002081_perinatal_lethality0.65315421
130MP0004185_abnormal_adipocyte_glucose0.62761003
131MP0004085_abnormal_heartbeat0.61680959
132MP0000751_myopathy0.60357646

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.36366704
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.36366704
3Neurofibrillary tangles (HP:0002185)5.86142466
4Abnormality of the corticospinal tract (HP:0002492)5.08756014
5Parakeratosis (HP:0001036)4.44590170
6Polyphagia (HP:0002591)4.27283371
7Cerebral inclusion bodies (HP:0100314)4.25856887
8Sensory axonal neuropathy (HP:0003390)4.25018046
9Peripheral hypomyelination (HP:0007182)4.16301201
10Myokymia (HP:0002411)3.85956716
11Supranuclear gaze palsy (HP:0000605)3.84200004
12Gait imbalance (HP:0002141)3.78500131
13Spastic gait (HP:0002064)3.70456452
14Termporal pattern (HP:0011008)3.65468146
15Insidious onset (HP:0003587)3.65468146
16Drooling (HP:0002307)3.49935603
17Onion bulb formation (HP:0003383)3.37208176
18Cortical dysplasia (HP:0002539)3.34119553
19Excessive salivation (HP:0003781)3.29244702
20Focal motor seizures (HP:0011153)3.27819920
21Congenital primary aphakia (HP:0007707)3.25249334
22True hermaphroditism (HP:0010459)3.23429050
23Intention tremor (HP:0002080)3.22917878
24Ankle clonus (HP:0011448)3.21785703
25Medial flaring of the eyebrow (HP:0010747)3.20417507
26Dysmetria (HP:0001310)3.20198003
27Alacrima (HP:0000522)3.16047179
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.13034777
29Abnormality of glycolysis (HP:0004366)3.09293419
30Increased serum pyruvate (HP:0003542)3.09293419
31Nephrogenic diabetes insipidus (HP:0009806)3.07192001
32Cerebral hypomyelination (HP:0006808)3.02616928
33Oligodactyly (hands) (HP:0001180)3.00796536
34Amyotrophic lateral sclerosis (HP:0007354)2.97118395
35Abnormal eating behavior (HP:0100738)2.93007943
36Scanning speech (HP:0002168)2.92159409
37Retinal dysplasia (HP:0007973)2.86104840
38Febrile seizures (HP:0002373)2.84906401
39Abnormal auditory evoked potentials (HP:0006958)2.76376106
40Specific learning disability (HP:0001328)2.75538186
41Megalencephaly (HP:0001355)2.74757686
42Lissencephaly (HP:0001339)2.72335999
43Leukodystrophy (HP:0002415)2.63545419
44Genital tract atresia (HP:0001827)2.62674190
45Aplasia involving bones of the upper limbs (HP:0009823)2.61439707
46Aplasia of the phalanges of the hand (HP:0009802)2.61439707
47Aplasia involving bones of the extremities (HP:0009825)2.61439707
48Pancreatic fibrosis (HP:0100732)2.59425621
49Akinesia (HP:0002304)2.57094697
50Anteriorly placed anus (HP:0001545)2.53790571
51Slow saccadic eye movements (HP:0000514)2.53393434
52Agitation (HP:0000713)2.52022443
53Decreased lacrimation (HP:0000633)2.51472520
54Hypoplastic pelvis (HP:0008839)2.51075887
55Focal seizures (HP:0007359)2.50402163
56Action tremor (HP:0002345)2.50063772
57Aplasia/Hypoplasia of the brainstem (HP:0007362)2.47404869
58Hypoplasia of the brainstem (HP:0002365)2.47404869
59Nephronophthisis (HP:0000090)2.46206168
60Pachygyria (HP:0001302)2.46080366
61Absent septum pellucidum (HP:0001331)2.44308967
62Thickened helices (HP:0000391)2.44240754
63Coronal craniosynostosis (HP:0004440)2.43436792
64Abnormality of the labia minora (HP:0012880)2.42976914
65Abnormality of the lower motor neuron (HP:0002366)2.42522942
66Genetic anticipation (HP:0003743)2.42469437
67Abnormal ciliary motility (HP:0012262)2.42102346
68Clumsiness (HP:0002312)2.42081867
69Lower limb muscle weakness (HP:0007340)2.41544320
70Pancreatic cysts (HP:0001737)2.40215141
71Impaired vibration sensation in the lower limbs (HP:0002166)2.38774626
72Poor coordination (HP:0002370)2.36482455
73Increased circulating renin level (HP:0000848)2.32488425
74Hemiplegia (HP:0002301)2.30604576
75Absent speech (HP:0001344)2.27804746
76Generalized tonic-clonic seizures (HP:0002069)2.27233958
77Absence seizures (HP:0002121)2.25860267
78Congenital ichthyosiform erythroderma (HP:0007431)2.24633943
79Abnormality of midbrain morphology (HP:0002418)2.24109064
80Molar tooth sign on MRI (HP:0002419)2.24109064
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22508208
82Intestinal atresia (HP:0011100)2.21917355
83Epileptic encephalopathy (HP:0200134)2.21264316
84Morphological abnormality of the inner ear (HP:0011390)2.21124055
85Broad-based gait (HP:0002136)2.18995178
86Broad foot (HP:0001769)2.18907275
87Partial agenesis of the corpus callosum (HP:0001338)2.18747551
88Urinary urgency (HP:0000012)2.18460534
89Synostosis involving the elbow (HP:0003938)2.17268651
90Humeroradial synostosis (HP:0003041)2.17268651
91Failure to thrive in infancy (HP:0001531)2.16576396
92Oligodactyly (HP:0012165)2.16141504
93Abnormality of the septum pellucidum (HP:0007375)2.14093051
94Cerebral hemorrhage (HP:0001342)2.10992184
95Split foot (HP:0001839)2.10955927
96Cupped ear (HP:0000378)2.10908393
97Optic nerve hypoplasia (HP:0000609)2.09285898
98Anomalous pulmonary venous return (HP:0010772)2.08711120
99Atonic seizures (HP:0010819)2.08218394
100Pheochromocytoma (HP:0002666)2.07928901
101Supernumerary spleens (HP:0009799)2.07182050
102Morphological abnormality of the pyramidal tract (HP:0002062)2.06829489
103Premature skin wrinkling (HP:0100678)2.05818084
104Segmental peripheral demyelination/remyelination (HP:0003481)2.05687025
105Abnormality of the middle phalanges of the toes (HP:0010183)2.01327873
106Dysdiadochokinesis (HP:0002075)2.01123520
107Hyperglycinemia (HP:0002154)2.01065174
108Spastic tetraplegia (HP:0002510)2.00772470
109Amblyopia (HP:0000646)1.98796117
110Hypoplasia of the iris (HP:0007676)1.97653506
111Clonus (HP:0002169)1.97186139
112Metabolic alkalosis (HP:0200114)1.96872992
113Hypsarrhythmia (HP:0002521)1.95716444
114Sclerocornea (HP:0000647)1.95249498
115Spastic paraparesis (HP:0002313)1.95200468
116Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94958587
117Abnormality of salivation (HP:0100755)1.94520909
118Progressive cerebellar ataxia (HP:0002073)1.93673954
119Abnormality of the renal medulla (HP:0100957)1.92267945
120Epileptiform EEG discharges (HP:0011182)1.91438381
121Postaxial hand polydactyly (HP:0001162)1.91343908
122Bowel incontinence (HP:0002607)1.90851385
123Hypoplasia of the corpus callosum (HP:0002079)1.90031568
124Stridor (HP:0010307)1.89554121
125Abnormal respiratory motile cilium morphology (HP:0005938)1.89119656
126Abnormal respiratory epithelium morphology (HP:0012253)1.89119656
127Anencephaly (HP:0002323)1.88657745
128Steppage gait (HP:0003376)1.88550893
129Septo-optic dysplasia (HP:0100842)1.87572415
130EEG with generalized epileptiform discharges (HP:0011198)1.87372492
131CNS hypomyelination (HP:0003429)1.86060754
132Generalized myoclonic seizures (HP:0002123)1.83597347
133Decreased motor nerve conduction velocity (HP:0003431)1.83195622
134Myelomeningocele (HP:0002475)1.83021984
135Type II lissencephaly (HP:0007260)1.82617699
136Narrow forehead (HP:0000341)1.82399695
137Aplasia/Hypoplasia of the lens (HP:0008063)1.82376306
138Esophageal atresia (HP:0002032)1.81553235
139Vitreoretinal degeneration (HP:0000655)1.81242794
140Hemiparesis (HP:0001269)1.81018003
141White forelock (HP:0002211)1.80101716
142Spastic tetraparesis (HP:0001285)1.80037673
143Inability to walk (HP:0002540)1.79287904
144Foot dorsiflexor weakness (HP:0009027)1.79221365
145Anophthalmia (HP:0000528)1.78374478
146Hammertoe (HP:0001765)1.78052883
147Sleep apnea (HP:0010535)1.77625719
148Progressive inability to walk (HP:0002505)1.77491765
149Abnormal large intestine physiology (HP:0012700)1.77451132
150Hyperventilation (HP:0002883)1.77433435
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.77292201
152Abnormality of the pulmonary veins (HP:0011718)1.77122386
153Hypophosphatemic rickets (HP:0004912)1.76529908
154Abnormal hair whorl (HP:0010721)1.76461770
155Mixed hearing impairment (HP:0000410)1.75747136
156Infantile muscular hypotonia (HP:0008947)1.75026711
157Exotropia (HP:0000577)1.74745515
158Esotropia (HP:0000565)1.74151283
159Urinary bladder sphincter dysfunction (HP:0002839)1.73814079
160Dialeptic seizures (HP:0011146)1.73724313
161Abnormal respiratory motile cilium physiology (HP:0012261)1.72695901
162Polymicrogyria (HP:0002126)1.72068103
163Neuroendocrine neoplasm (HP:0100634)1.71158659
164Micropenis (HP:0000054)1.70921520
165Poor speech (HP:0002465)1.70647549
166Occipital encephalocele (HP:0002085)1.70539306
167Chronic hepatic failure (HP:0100626)1.70426038
168Hypomagnesemia (HP:0002917)1.70215251
169Limb dystonia (HP:0002451)1.69956396
170Vaginal atresia (HP:0000148)1.69865591
171Gastrointestinal atresia (HP:0002589)1.69848294
172Urinary incontinence (HP:0000020)1.69789081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.47889503
2OXSR14.02132242
3EPHA33.12033503
4TNIK2.87505206
5MARK12.76644294
6BCR2.56066499
7PKN12.55015470
8CDK192.31261241
9WNK42.29930142
10PNCK2.25076554
11FGFR22.24949997
12EPHA42.23396459
13UHMK12.13890296
14MAPKAPK52.02714595
15CASK1.90810217
16SIK21.82290787
17TYRO31.80567958
18PBK1.74521186
19WNK11.63403541
20DYRK31.59013939
21NTRK11.57335166
22MAP2K41.56434915
23PRPF4B1.56430119
24LIMK11.56413452
25PAK61.54438730
26NTRK21.54156303
27CSNK1G31.53766521
28DYRK21.51015135
29CSNK1A1L1.49912716
30MAPK131.48164290
31TRIM281.47535498
32CAMK2B1.43371628
33ROCK21.37421885
34SGK2231.35233432
35SGK4941.35233432
36MET1.34834396
37NEK61.32848119
38CSNK1G21.32710134
39ERBB31.30457163
40SGK21.26717584
41DYRK1B1.26424720
42NTRK31.23212853
43CSNK1G11.20839747
44FGR1.20613050
45ICK1.19883704
46CDK51.15344709
47PAK31.14035456
48CAMK2D1.13298967
49PHKG11.12824320
50PHKG21.12824320
51CLK11.11107024
52MAP4K21.10340707
53MARK21.08454278
54MST41.05671373
55MAP3K91.05067028
56CDK140.98375715
57CAMK2A0.97335612
58IRAK20.94401395
59MAP3K40.92720987
60CDK150.91588339
61TESK20.91485138
62FES0.90051026
63CDK180.89568329
64CAMKK20.89068817
65FRK0.87984123
66MINK10.82832073
67CDK11A0.82799867
68EPHB20.82664816
69MUSK0.82504039
70INSRR0.79205763
71CAMK2G0.78833348
72CAMK1G0.78007860
73BCKDK0.77621438
74CAMK40.77276174
75SRPK10.73944756
76PRKCE0.73435373
77ERBB20.73268767
78TNK20.72796924
79PRKCQ0.71296646
80RPS6KA40.69503049
81PRKD10.68482634
82FYN0.65985471
83CAMKK10.65825968
84PRKCZ0.64180838
85MAP2K70.62951490
86STK110.60157724
87BMPR1B0.60069136
88GRK70.58514417
89PDPK10.57531266
90TAOK30.55806195
91DYRK1A0.55667200
92SGK30.55479425
93PRKG10.53714454
94DAPK20.52045716
95CSNK1D0.52020447
96CAMK10.50191241
97ERBB40.49263757
98GSK3A0.48218704
99MAP3K60.47616483
100DDR20.47403666
101PRKACB0.46595972
102PLK20.46038548
103MAP3K50.45576524
104KSR20.43706682
105SIK30.42576269
106CSNK1A10.41317186
107MAPK150.41167579
108WNK30.40502330
109SGK10.39956805
110PRKD30.39667544
111DMPK0.39149289
112CAMK1D0.38714952
113PRKACA0.38312308
114ROCK10.38178463
115PRKCH0.36507433
116PRKCG0.35899890
117PINK10.35528699
118PDGFRB0.35395376
119MKNK10.35062910
120ADRBK20.33791728
121ADRBK10.33709946
122MAPK90.33025139
123CSNK1E0.32169686
124KSR10.31807886
125RPS6KA20.31190412
126IRAK10.31181514
127MAP3K20.31151949
128ARAF0.30448133
129PRKAA10.30200210
130RPS6KA30.29291176
131PDK10.28968074
132MAPK100.28761992
133INSR0.28509830
134PRKDC0.27501557
135CDK30.27240403
136RPS6KA50.25627360
137TSSK60.25565176
138YES10.24696397

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.40970412
2Steroid biosynthesis_Homo sapiens_hsa001004.45912400
3Fatty acid elongation_Homo sapiens_hsa000623.71447493
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.60557925
5Ether lipid metabolism_Homo sapiens_hsa005652.71772368
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30732831
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20268288
8* Axon guidance_Homo sapiens_hsa043602.00825759
9Glutamatergic synapse_Homo sapiens_hsa047241.96065645
10GABAergic synapse_Homo sapiens_hsa047271.89576630
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81049811
12Nicotine addiction_Homo sapiens_hsa050331.77002377
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66656707
14Serotonergic synapse_Homo sapiens_hsa047261.61333747
15Morphine addiction_Homo sapiens_hsa050321.58104389
16Butanoate metabolism_Homo sapiens_hsa006501.57508509
17Oxidative phosphorylation_Homo sapiens_hsa001901.51814387
18Long-term depression_Homo sapiens_hsa047301.41268270
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38482848
20Sulfur metabolism_Homo sapiens_hsa009201.37469134
21Circadian entrainment_Homo sapiens_hsa047131.36496618
22Sphingolipid metabolism_Homo sapiens_hsa006001.28435386
23Dopaminergic synapse_Homo sapiens_hsa047281.18919863
24Synaptic vesicle cycle_Homo sapiens_hsa047211.18797054
25Cholinergic synapse_Homo sapiens_hsa047251.18546190
26Cocaine addiction_Homo sapiens_hsa050301.18280480
27Linoleic acid metabolism_Homo sapiens_hsa005911.15556333
28Renal cell carcinoma_Homo sapiens_hsa052111.15474462
29Alzheimers disease_Homo sapiens_hsa050101.14955840
30Vitamin B6 metabolism_Homo sapiens_hsa007501.13864999
31Parkinsons disease_Homo sapiens_hsa050121.11011477
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08203895
33Salivary secretion_Homo sapiens_hsa049701.05673391
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01596921
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99424295
36Cardiac muscle contraction_Homo sapiens_hsa042600.99062675
37Collecting duct acid secretion_Homo sapiens_hsa049660.98146352
38Gastric acid secretion_Homo sapiens_hsa049710.97359385
39Nitrogen metabolism_Homo sapiens_hsa009100.96356138
40Basal cell carcinoma_Homo sapiens_hsa052170.94944494
41Regulation of autophagy_Homo sapiens_hsa041400.93690290
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92370356
43Sphingolipid signaling pathway_Homo sapiens_hsa040710.91775060
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91693003
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91563569
46Olfactory transduction_Homo sapiens_hsa047400.90207532
47Amphetamine addiction_Homo sapiens_hsa050310.88876655
48Long-term potentiation_Homo sapiens_hsa047200.88268361
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.86153565
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85968544
51Notch signaling pathway_Homo sapiens_hsa043300.85144625
52Renin secretion_Homo sapiens_hsa049240.84977847
53Phototransduction_Homo sapiens_hsa047440.84954773
54Tight junction_Homo sapiens_hsa045300.84868642
55Protein export_Homo sapiens_hsa030600.83594857
56Gap junction_Homo sapiens_hsa045400.82553485
57Taste transduction_Homo sapiens_hsa047420.81900698
58Vibrio cholerae infection_Homo sapiens_hsa051100.81900370
59Ras signaling pathway_Homo sapiens_hsa040140.80738477
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80721919
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79483978
62Histidine metabolism_Homo sapiens_hsa003400.77724156
63Estrogen signaling pathway_Homo sapiens_hsa049150.76308469
64ErbB signaling pathway_Homo sapiens_hsa040120.76282946
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.76047441
66Dorso-ventral axis formation_Homo sapiens_hsa043200.72948722
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71517366
68Oxytocin signaling pathway_Homo sapiens_hsa049210.70655309
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70004314
70Hippo signaling pathway_Homo sapiens_hsa043900.69845688
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69373850
72Ovarian steroidogenesis_Homo sapiens_hsa049130.69056174
73Fatty acid metabolism_Homo sapiens_hsa012120.66972066
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65615938
75Calcium signaling pathway_Homo sapiens_hsa040200.61829378
76cAMP signaling pathway_Homo sapiens_hsa040240.61822369
77Insulin secretion_Homo sapiens_hsa049110.60547114
78Type II diabetes mellitus_Homo sapiens_hsa049300.60420059
79Choline metabolism in cancer_Homo sapiens_hsa052310.59741820
80Endocytosis_Homo sapiens_hsa041440.58396607
81Propanoate metabolism_Homo sapiens_hsa006400.58309695
82Fatty acid biosynthesis_Homo sapiens_hsa000610.57941046
83Arginine and proline metabolism_Homo sapiens_hsa003300.57037471
84Pancreatic secretion_Homo sapiens_hsa049720.56992907
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.56332440
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.56159300
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55484428
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51881902
89Hedgehog signaling pathway_Homo sapiens_hsa043400.51722449
90Circadian rhythm_Homo sapiens_hsa047100.51195348
91GnRH signaling pathway_Homo sapiens_hsa049120.51121720
92Melanogenesis_Homo sapiens_hsa049160.50359943
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49756926
94Huntingtons disease_Homo sapiens_hsa050160.49417595
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48555593
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47736059
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46492373
98Oocyte meiosis_Homo sapiens_hsa041140.46151515
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45277075
100Rheumatoid arthritis_Homo sapiens_hsa053230.44411585
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42751599
102beta-Alanine metabolism_Homo sapiens_hsa004100.42688454
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41941381
104MAPK signaling pathway_Homo sapiens_hsa040100.41916910
105Phagosome_Homo sapiens_hsa041450.41795901
106Colorectal cancer_Homo sapiens_hsa052100.41681960
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40600048
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40473717
109Prion diseases_Homo sapiens_hsa050200.39543081
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39490133
111Peroxisome_Homo sapiens_hsa041460.38367305
112Dilated cardiomyopathy_Homo sapiens_hsa054140.38257080
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37624598
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36827805
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36631694
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36401799
117Arachidonic acid metabolism_Homo sapiens_hsa005900.35957319
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35692422
119Thyroid hormone synthesis_Homo sapiens_hsa049180.34760501
120Alcoholism_Homo sapiens_hsa050340.34259506
121Wnt signaling pathway_Homo sapiens_hsa043100.34070858
122Rap1 signaling pathway_Homo sapiens_hsa040150.33443824
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33336418
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32600637
125Bile secretion_Homo sapiens_hsa049760.32597047

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