EPHA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.49264547
2protein localization to synapse (GO:0035418)5.31106579
3G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.21862831
4positive regulation of synapse maturation (GO:0090129)5.19764381
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.16007293
6vocalization behavior (GO:0071625)5.09623486
7gamma-aminobutyric acid signaling pathway (GO:0007214)5.07987161
8glutamate receptor signaling pathway (GO:0007215)5.05450708
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.83970592
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74342278
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.74062507
12negative regulation of cytosolic calcium ion concentration (GO:0051481)4.71857966
13regulation of synapse structural plasticity (GO:0051823)4.68483674
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.50107834
15innervation (GO:0060384)4.48155291
16glutamate secretion (GO:0014047)4.36024197
17synaptic transmission, glutamatergic (GO:0035249)4.27654976
18regulation of glutamate receptor signaling pathway (GO:1900449)4.27435508
19neuron cell-cell adhesion (GO:0007158)4.26861897
20limb bud formation (GO:0060174)4.23333543
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21947243
22regulation of synapse maturation (GO:0090128)4.21140272
23neuron recognition (GO:0008038)4.16733285
24synaptic vesicle endocytosis (GO:0048488)4.15539831
25neuron-neuron synaptic transmission (GO:0007270)4.14805037
26positive regulation of dendritic spine morphogenesis (GO:0061003)4.11621931
27detection of light stimulus involved in visual perception (GO:0050908)4.09884325
28detection of light stimulus involved in sensory perception (GO:0050962)4.09884325
29axonal fasciculation (GO:0007413)4.04145756
30behavioral defense response (GO:0002209)4.01838951
31behavioral fear response (GO:0001662)4.01838951
32pyrimidine nucleobase catabolic process (GO:0006208)4.00518648
33inner ear receptor cell development (GO:0060119)3.98203937
34lateral sprouting from an epithelium (GO:0060601)3.97038572
35synaptic vesicle maturation (GO:0016188)3.92266486
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89008924
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.88458485
38long-term synaptic potentiation (GO:0060291)3.85212821
39neurotransmitter-gated ion channel clustering (GO:0072578)3.82805891
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.82622166
41long term synaptic depression (GO:0060292)3.81846486
42regulation of synaptic vesicle exocytosis (GO:2000300)3.72657883
43exploration behavior (GO:0035640)3.69767332
44membrane depolarization during action potential (GO:0086010)3.64167928
45cell communication by electrical coupling (GO:0010644)3.62454010
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61641177
47cochlea development (GO:0090102)3.60847785
48cellular potassium ion homeostasis (GO:0030007)3.60761456
49response to histamine (GO:0034776)3.59623713
50neuron fate determination (GO:0048664)3.59533352
51regulation of neuronal synaptic plasticity (GO:0048168)3.57000905
52fear response (GO:0042596)3.56020114
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.54061604
54regulation of synaptic plasticity (GO:0048167)3.52628940
55regulation of postsynaptic membrane potential (GO:0060078)3.50668009
56sodium ion export (GO:0071436)3.50112352
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49646594
58response to pheromone (GO:0019236)3.48580288
59establishment of nucleus localization (GO:0040023)3.47646835
60regulation of synaptic vesicle transport (GO:1902803)3.46963481
61olfactory bulb development (GO:0021772)3.46686411
62cerebral cortex radially oriented cell migration (GO:0021799)3.46283598
63dendrite morphogenesis (GO:0048813)3.42252217
64transmission of nerve impulse (GO:0019226)3.38773195
65calcium ion import (GO:0070509)3.37560467
66central nervous system projection neuron axonogenesis (GO:0021952)3.35461540
67striatum development (GO:0021756)3.34704032
68regulation of dendritic spine morphogenesis (GO:0061001)3.32675991
69startle response (GO:0001964)3.31471400
70presynaptic membrane assembly (GO:0097105)3.31199345
71long-term memory (GO:0007616)3.29460845
72appendage development (GO:0048736)3.29391374
73limb development (GO:0060173)3.29391374
74regulation of vesicle fusion (GO:0031338)3.27512623
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25130589
76regulation of timing of cell differentiation (GO:0048505)3.24128409
77regulation of development, heterochronic (GO:0040034)3.24006639
78learning (GO:0007612)3.23763967
79postsynaptic membrane organization (GO:0001941)3.22808048
80synapse assembly (GO:0007416)3.20701750
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.19994668
82relaxation of smooth muscle (GO:0044557)3.18552410
83cellular sodium ion homeostasis (GO:0006883)3.15665635
84spinal cord association neuron differentiation (GO:0021527)3.15534354
85neurotransmitter secretion (GO:0007269)3.15306106
86locomotory exploration behavior (GO:0035641)3.14596832
87membrane depolarization (GO:0051899)3.12529173
88positive regulation of dendritic spine development (GO:0060999)3.11658830
89positive regulation of membrane potential (GO:0045838)3.09205550
90nucleobase catabolic process (GO:0046113)3.09003787
91synaptic transmission (GO:0007268)3.06626964
92establishment of synaptic vesicle localization (GO:0097480)3.05241099
93synaptic vesicle transport (GO:0048489)3.05241099
94tongue development (GO:0043586)3.03722384
95retinal cone cell development (GO:0046549)3.02392904
96regulation of neurotransmitter secretion (GO:0046928)3.00144509
97potassium ion homeostasis (GO:0055075)2.98873411
98cell proliferation in forebrain (GO:0021846)2.98339209
99artery development (GO:0060840)2.98296149
100regulation of synapse organization (GO:0050807)2.97461787
101regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.97211204
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97106048
103positive regulation of potassium ion transmembrane transport (GO:1901381)2.96040046
104presynaptic membrane organization (GO:0097090)2.95878567
105cerebellar Purkinje cell differentiation (GO:0021702)2.94360009
106midbrain development (GO:0030901)2.93391784
107central nervous system neuron axonogenesis (GO:0021955)2.93310632
108negative regulation of axon guidance (GO:1902668)2.92299366
109membrane hyperpolarization (GO:0060081)2.91899795
110* retinal ganglion cell axon guidance (GO:0031290)2.91157684
111axon extension involved in axon guidance (GO:0048846)2.90513258
112neuron projection extension involved in neuron projection guidance (GO:1902284)2.90513258
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90508786
114negative regulation of translation, ncRNA-mediated (GO:0040033)2.90508786
115regulation of translation, ncRNA-mediated (GO:0045974)2.90508786
116associative learning (GO:0008306)2.89974101
117atrial cardiac muscle cell action potential (GO:0086014)2.89948325
118intraciliary transport (GO:0042073)2.89736384
119retinal rod cell development (GO:0046548)2.89118795
120otic vesicle formation (GO:0030916)2.88767663
121regulation of non-canonical Wnt signaling pathway (GO:2000050)2.88362821
122dendrite development (GO:0016358)2.88342331
123positive regulation of cardiac muscle cell differentiation (GO:2000727)2.86266475
124behavioral response to ethanol (GO:0048149)2.85207880
125thalamus development (GO:0021794)2.85036420
126dendritic spine morphogenesis (GO:0060997)2.84757752
127bone trabecula formation (GO:0060346)2.83742052
128regulation of female receptivity (GO:0045924)2.83060056
129phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.82656876
130positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80149617
131regulation of collateral sprouting (GO:0048670)2.76089682
132somite development (GO:0061053)2.75727705
133spinal cord development (GO:0021510)2.74551797
134dorsal/ventral axis specification (GO:0009950)2.72880097
135lung-associated mesenchyme development (GO:0060484)2.72444340
136cardiac chamber formation (GO:0003207)2.69759753
137negative regulation of astrocyte differentiation (GO:0048712)2.69503706
138prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.68911980
139positive regulation of embryonic development (GO:0040019)2.67610093
140cell migration in hindbrain (GO:0021535)2.64937890
141negative regulation of dendrite development (GO:2000171)2.63841674
142positive regulation of gastrulation (GO:2000543)2.60916339
143regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60249998
144layer formation in cerebral cortex (GO:0021819)2.60083101
145neuronal stem cell maintenance (GO:0097150)2.56051605
146dentate gyrus development (GO:0021542)2.55689083
147cell differentiation in spinal cord (GO:0021515)2.54209833
148regulation of growth hormone secretion (GO:0060123)2.50953525
149regulation of axon guidance (GO:1902667)2.50456299
150hippocampus development (GO:0021766)2.50310166
151kidney morphogenesis (GO:0060993)2.49968958
152specification of organ identity (GO:0010092)2.48892759
153heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.48470830
154apical protein localization (GO:0045176)2.47516375
155cerebral cortex development (GO:0021987)2.45608443
156positive regulation of cardiac muscle tissue development (GO:0055025)2.45243487
157positive regulation of neuroblast proliferation (GO:0002052)2.44725957
158cranial nerve morphogenesis (GO:0021602)2.42712953
159pre-miRNA processing (GO:0031054)2.41706227
160cornea development in camera-type eye (GO:0061303)2.40147947
161cardiac ventricle formation (GO:0003211)2.39994889
162neuron migration (GO:0001764)2.37002694
163hindbrain development (GO:0030902)2.36016909
164camera-type eye morphogenesis (GO:0048593)2.35331476
165paraxial mesoderm development (GO:0048339)2.34943350
166regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.34320765
167negative regulation of axon extension involved in axon guidance (GO:0048843)2.33467866
168cerebral cortex cell migration (GO:0021795)2.33327630
169gastrulation with mouth forming second (GO:0001702)2.31024275
170negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.29264496
171forebrain neuron differentiation (GO:0021879)2.29148812
172embryonic foregut morphogenesis (GO:0048617)2.28430314
173nonmotile primary cilium assembly (GO:0035058)2.27748309
174embryonic digestive tract morphogenesis (GO:0048557)2.27453912
175negative regulation of axon extension (GO:0030517)2.27341012
176cell surface receptor signaling pathway involved in heart development (GO:0061311)2.25618503
177radial glial cell differentiation (GO:0060019)2.24296536
178regulation of cardioblast differentiation (GO:0051890)2.23389090
179negative regulation of glial cell differentiation (GO:0045686)2.21653762
180negative regulation of oligodendrocyte differentiation (GO:0048715)2.20735279
181* ephrin receptor signaling pathway (GO:0048013)2.19377576
182positive regulation of synapse assembly (GO:0051965)2.19004446
183positive regulation of cardiac muscle tissue growth (GO:0055023)2.18588857
184smoothened signaling pathway (GO:0007224)2.18560937
185positive regulation of cardiac muscle cell proliferation (GO:0060045)2.17966160
186retina layer formation (GO:0010842)2.17916806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86715577
2GBX2_23144817_ChIP-Seq_PC3_Human4.24746256
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.95356506
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11604981
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07923665
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05293403
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.85975618
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77043036
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.73381413
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64346157
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64000098
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.61850301
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61242873
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61242873
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60699727
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.45419277
17REST_21632747_ChIP-Seq_MESCs_Mouse2.42631192
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32006903
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31703349
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.27149795
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26873114
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26262600
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.24877272
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22673150
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13384570
26DROSHA_22980978_ChIP-Seq_HELA_Human2.12905197
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11675966
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11244113
29POU5F1_16153702_ChIP-ChIP_HESCs_Human2.11074952
30TP63_19390658_ChIP-ChIP_HaCaT_Human2.10533596
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10356983
32AR_21572438_ChIP-Seq_LNCaP_Human2.09785657
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.95376995
34* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93294051
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91715213
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86889692
37SMAD4_21799915_ChIP-Seq_A2780_Human1.85969094
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.85835611
39* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82690414
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81552998
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79241613
42* FUS_26573619_Chip-Seq_HEK293_Human1.76446803
43* REST_18959480_ChIP-ChIP_MESCs_Mouse1.75066246
44* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73901997
45* P300_19829295_ChIP-Seq_ESCs_Human1.70361430
46* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69109968
47TAF15_26573619_Chip-Seq_HEK293_Human1.68807448
48* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59459189
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.57996672
50E2F7_22180533_ChIP-Seq_HELA_Human1.57638237
51AR_25329375_ChIP-Seq_VCAP_Human1.52378155
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.51230866
53IGF1R_20145208_ChIP-Seq_DFB_Human1.50513982
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49233253
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.48300091
56* RNF2_27304074_Chip-Seq_NSC_Mouse1.45708516
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42361593
58VDR_22108803_ChIP-Seq_LS180_Human1.41598591
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41592317
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40634971
61* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39155869
62* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38837570
63* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37616436
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.37546816
65* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33773723
66ZNF274_21170338_ChIP-Seq_K562_Hela1.32931656
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.32181943
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32160738
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31504423
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31174197
71STAT3_23295773_ChIP-Seq_U87_Human1.31005061
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30089053
73* ISL1_27105846_Chip-Seq_CPCs_Mouse1.29745141
74* AR_19668381_ChIP-Seq_PC3_Human1.28374903
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27502815
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26843797
77* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26710366
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24868761
79* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22080453
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.21805179
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21671269
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21671269
83* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21281799
84BCAT_22108803_ChIP-Seq_LS180_Human1.19947353
85* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19893757
86* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19142231
87* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18589737
88* TCF4_23295773_ChIP-Seq_U87_Human1.18095068
89* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17642565
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16973329
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16657862
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15332997
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14503259
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.13794263
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.13722889
96* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13017746
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12560399
98TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11464533
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11024633
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09439846
101* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08631060
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08378954
103* SOX9_26525672_Chip-Seq_HEART_Mouse1.07938356
104JUN_21703547_ChIP-Seq_K562_Human1.07758938
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07114109
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06762338
107* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06668082
108RUNX2_22187159_ChIP-Seq_PCA_Human1.06457605
109ER_23166858_ChIP-Seq_MCF-7_Human1.06244043
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05934998
111* EWS_26573619_Chip-Seq_HEK293_Human1.05706434
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05254823
113ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04655285
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.03489991
115WT1_19549856_ChIP-ChIP_CCG9911_Human1.03291799
116* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02900175
117AHR_22903824_ChIP-Seq_MCF-7_Human1.02228875
118* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01936918
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.01125237
120* NANOG_16153702_ChIP-ChIP_HESCs_Human1.01112521
121TP53_18474530_ChIP-ChIP_U2OS_Human1.00912420
122* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00626204
123* TP53_20018659_ChIP-ChIP_R1E_Mouse0.98562072
124* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96824975
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96337362
126CBP_20019798_ChIP-Seq_JUKART_Human0.95715986
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95715986
128IRF1_19129219_ChIP-ChIP_H3396_Human0.95370954
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.94135314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.62415057
2MP0003880_abnormal_central_pattern4.88950309
3MP0000566_synostosis4.86209391
4MP0003635_abnormal_synaptic_transmissio3.69718504
5MP0010030_abnormal_orbit_morphology3.37384258
6MP0002063_abnormal_learning/memory/cond3.24314041
7MP0009745_abnormal_behavioral_response3.06034544
8MP0005551_abnormal_eye_electrophysiolog2.76609775
9MP0001968_abnormal_touch/_nociception2.68219274
10MP0002064_seizures2.67703165
11MP0002572_abnormal_emotion/affect_behav2.60511853
12MP0000537_abnormal_urethra_morphology2.59423566
13MP0001486_abnormal_startle_reflex2.53013338
14MP0004270_analgesia2.51030972
15MP0002938_white_spotting2.49485866
16MP0002736_abnormal_nociception_after2.44959278
17MP0001984_abnormal_olfaction2.43321090
18MP0002272_abnormal_nervous_system2.34315650
19MP0001502_abnormal_circadian_rhythm2.25908251
20MP0002735_abnormal_chemical_nociception2.22831704
21MP0003937_abnormal_limbs/digits/tail_de2.17983049
22MP0009046_muscle_twitch2.02025579
23MP0001501_abnormal_sleep_pattern2.01893806
24MP0001440_abnormal_grooming_behavior2.00049380
25MP0009053_abnormal_anal_canal1.95567761
26MP0002734_abnormal_mechanical_nocicepti1.91643277
27MP0000778_abnormal_nervous_system1.88303790
28MP0001293_anophthalmia1.87882134
29MP0008057_abnormal_DNA_replication1.86696528
30MP0002184_abnormal_innervation1.84525851
31MP0006292_abnormal_olfactory_placode1.82985858
32MP0002067_abnormal_sensory_capabilities1.82625986
33MP0002090_abnormal_vision1.77348775
34MP0002233_abnormal_nose_morphology1.73254031
35MP0003136_yellow_coat_color1.72075438
36MP0006276_abnormal_autonomic_nervous1.71123990
37MP0006072_abnormal_retinal_apoptosis1.70442199
38MP0005423_abnormal_somatic_nervous1.68066604
39MP0003787_abnormal_imprinting1.63141264
40MP0001188_hyperpigmentation1.62679180
41MP0001346_abnormal_lacrimal_gland1.60345264
42MP0000049_abnormal_middle_ear1.59035561
43MP0003137_abnormal_impulse_conducting1.58535700
44MP0005248_abnormal_Harderian_gland1.57770021
45MP0002697_abnormal_eye_size1.57162432
46MP0004145_abnormal_muscle_electrophysio1.55941716
47MP0000579_abnormal_nail_morphology1.55344119
48MP0002557_abnormal_social/conspecific_i1.54668462
49MP0004233_abnormal_muscle_weight1.51359467
50MP0002822_catalepsy1.50180605
51MP0005187_abnormal_penis_morphology1.49500308
52MP0003122_maternal_imprinting1.49257863
53MP0004215_abnormal_myocardial_fiber1.48213708
54MP0001970_abnormal_pain_threshold1.47930251
55MP0000428_abnormal_craniofacial_morphol1.47528371
56MP0003385_abnormal_body_wall1.47191782
57MP0002102_abnormal_ear_morphology1.45689561
58* MP0002882_abnormal_neuron_morphology1.45170555
59MP0000955_abnormal_spinal_cord1.41908636
60MP0000631_abnormal_neuroendocrine_gland1.41571636
61MP0005646_abnormal_pituitary_gland1.41150534
62MP0000751_myopathy1.40979056
63MP0005367_renal/urinary_system_phenotyp1.40951528
64MP0000516_abnormal_urinary_system1.40951528
65MP0000534_abnormal_ureter_morphology1.38906145
66MP0001286_abnormal_eye_development1.37844040
67MP0002249_abnormal_larynx_morphology1.37825312
68MP0001529_abnormal_vocalization1.37819392
69MP0003890_abnormal_embryonic-extraembry1.37234864
70MP0002733_abnormal_thermal_nociception1.35215418
71MP0003942_abnormal_urinary_system1.35072203
72MP0008569_lethality_at_weaning1.35068991
73MP0005386_behavior/neurological_phenoty1.33144223
74MP0004924_abnormal_behavior1.33144223
75MP0003755_abnormal_palate_morphology1.30538080
76MP0002909_abnormal_adrenal_gland1.30484468
77MP0004811_abnormal_neuron_physiology1.29390653
78MP0003879_abnormal_hair_cell1.23327284
79MP0002752_abnormal_somatic_nervous1.18969659
80MP0005195_abnormal_posterior_eye1.18473435
81MP0003567_abnormal_fetal_cardiomyocyte1.18116220
82MP0002066_abnormal_motor_capabilities/c1.16737835
83MP0002092_abnormal_eye_morphology1.15501419
84MP0005171_absent_coat_pigmentation1.14782251
85* MP0002152_abnormal_brain_morphology1.13809821
86MP0005253_abnormal_eye_physiology1.13557011
87MP0010386_abnormal_urinary_bladder1.11947765
88MP0003935_abnormal_craniofacial_develop1.10649881
89MP0005391_vision/eye_phenotype1.09635927
90MP0005394_taste/olfaction_phenotype1.08861325
91MP0005499_abnormal_olfactory_system1.08861325
92MP0009250_abnormal_appendicular_skeleto1.08809661
93MP0002111_abnormal_tail_morphology1.08223775
94MP0001177_atelectasis1.06876735
95MP0002876_abnormal_thyroid_physiology1.06335175
96MP0004085_abnormal_heartbeat1.01671360
97MP0002638_abnormal_pupillary_reflex1.00604679
98MP0004858_abnormal_nervous_system0.97934400
99MP0001963_abnormal_hearing_physiology0.97563929
100MP0002084_abnormal_developmental_patter0.96530481
101MP0003329_amyloid_beta_deposits0.96515319
102MP0002234_abnormal_pharynx_morphology0.95008705
103MP0002116_abnormal_craniofacial_bone0.94856952
104MP0003315_abnormal_perineum_morphology0.94638999
105MP0001905_abnormal_dopamine_level0.94145657
106MP0002069_abnormal_eating/drinking_beha0.94046629
107MP0002282_abnormal_trachea_morphology0.93344811
108MP0003121_genomic_imprinting0.92189760
109MP0002229_neurodegeneration0.91674105
110MP0003283_abnormal_digestive_organ0.90145781
111MP0005409_darkened_coat_color0.89419317
112MP0003950_abnormal_plasma_membrane0.88789807
113MP0000026_abnormal_inner_ear0.87693594
114MP0002081_perinatal_lethality0.87603646
115MP0000462_abnormal_digestive_system0.86604285
116MP0010094_abnormal_chromosome_stability0.86493971
117MP0002653_abnormal_ependyma_morphology0.85696544
118MP0003123_paternal_imprinting0.85202740
119MP0003633_abnormal_nervous_system0.84741777
120MP0002085_abnormal_embryonic_tissue0.84069342
121MP0004142_abnormal_muscle_tone0.83432701
122MP0005595_abnormal_vascular_smooth0.82762175
123* MP0003861_abnormal_nervous_system0.82428197
124MP0000383_abnormal_hair_follicle0.82301989
125MP0002109_abnormal_limb_morphology0.81414644
126MP0008789_abnormal_olfactory_epithelium0.80157725
127MP0002332_abnormal_exercise_endurance0.79568931
128MP0004133_heterotaxia0.79243574
129MP0009703_decreased_birth_body0.79107627
130MP0009780_abnormal_chondrocyte_physiolo0.78107450
131MP0002932_abnormal_joint_morphology0.78071523
132MP0000432_abnormal_head_morphology0.77630562
133MP0002751_abnormal_autonomic_nervous0.77496288
134MP0003938_abnormal_ear_development0.74566340
135MP0004782_abnormal_surfactant_physiolog0.72833644
136MP0003631_nervous_system_phenotype0.70072893
137MP0004742_abnormal_vestibular_system0.68114739
138MP0003119_abnormal_digestive_system0.65768525
139MP0004885_abnormal_endolymph0.64255198
140MP0001324_abnormal_eye_pigmentation0.63557244
141MP0005620_abnormal_muscle_contractility0.60959209
142MP0003634_abnormal_glial_cell0.60474853
143MP0001299_abnormal_eye_distance/0.60423951
144MP0010770_preweaning_lethality0.60417799
145MP0002082_postnatal_lethality0.60417799
146MP0010769_abnormal_survival0.59559271

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.74440385
2Congenital stationary night blindness (HP:0007642)6.43706826
3Epileptic encephalopathy (HP:0200134)5.79031521
4Febrile seizures (HP:0002373)5.54916031
5Central scotoma (HP:0000603)4.57731293
6Myokymia (HP:0002411)4.49403027
7Focal seizures (HP:0007359)4.24842051
8Visual hallucinations (HP:0002367)4.24277850
9Progressive cerebellar ataxia (HP:0002073)4.08504492
10Severe visual impairment (HP:0001141)4.05811941
11Absence seizures (HP:0002121)3.90347447
12Abnormality of macular pigmentation (HP:0008002)3.76385270
13Hyperventilation (HP:0002883)3.67612064
14Atonic seizures (HP:0010819)3.60260932
15Septo-optic dysplasia (HP:0100842)3.59140309
16Dialeptic seizures (HP:0011146)3.59012766
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.58564737
18Short 4th metacarpal (HP:0010044)3.58564737
19Excessive salivation (HP:0003781)3.21330023
20Drooling (HP:0002307)3.21330023
21Cutaneous finger syndactyly (HP:0010554)3.20511313
22Intestinal atresia (HP:0011100)3.17076427
23Abnormality of the labia minora (HP:0012880)3.12601419
24Scanning speech (HP:0002168)3.10456090
25Abnormality of the lower motor neuron (HP:0002366)3.07825418
26Vitreoretinal degeneration (HP:0000655)3.01303619
27Volvulus (HP:0002580)2.95732910
28Genetic anticipation (HP:0003743)2.94445490
29Protruding tongue (HP:0010808)2.93948303
30Abnormality of the 4th metacarpal (HP:0010012)2.93174002
31Generalized tonic-clonic seizures (HP:0002069)2.86892168
32Hypoplasia of the fovea (HP:0007750)2.78714737
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.78714737
34Broad-based gait (HP:0002136)2.78556067
35Cutaneous syndactyly (HP:0012725)2.76828080
36Abnormal rod and cone electroretinograms (HP:0008323)2.69845438
37Scotoma (HP:0000575)2.69329891
38Hepatoblastoma (HP:0002884)2.68993222
39Oligodactyly (HP:0012165)2.67083090
40Dysdiadochokinesis (HP:0002075)2.64708314
41Oligodactyly (hands) (HP:0001180)2.63323320
42Renal hypoplasia (HP:0000089)2.63249064
43Partial duplication of thumb phalanx (HP:0009944)2.61916358
44Esophageal atresia (HP:0002032)2.59084936
45Epileptiform EEG discharges (HP:0011182)2.57369634
46Preaxial foot polydactyly (HP:0001841)2.57004512
47Gastrointestinal atresia (HP:0002589)2.55943996
48Dysmetria (HP:0001310)2.50792684
49Hemiparesis (HP:0001269)2.46950561
50Impaired smooth pursuit (HP:0007772)2.46416142
51Aqueductal stenosis (HP:0002410)2.43285645
52Midline defect of the nose (HP:0004122)2.42304449
53Split foot (HP:0001839)2.40034848
54Abnormality of the fovea (HP:0000493)2.35564179
55Abnormal lung lobation (HP:0002101)2.35088838
56High anterior hairline (HP:0009890)2.34139371
57Gaze-evoked nystagmus (HP:0000640)2.31876223
58Amblyopia (HP:0000646)2.31316016
59Abnormality of the aortic arch (HP:0012303)2.29699309
60Medulloblastoma (HP:0002885)2.26771936
61Retinal dysplasia (HP:0007973)2.25970892
62Gait imbalance (HP:0002141)2.25647570
63Decreased circulating renin level (HP:0003351)2.24837987
64Partial duplication of the phalanx of hand (HP:0009999)2.24149408
65Absent speech (HP:0001344)2.18979908
66Optic nerve hypoplasia (HP:0000609)2.18966140
67Truncal ataxia (HP:0002078)2.17984907
68Trigonocephaly (HP:0000243)2.17114417
69Myelomeningocele (HP:0002475)2.14975419
70Nephronophthisis (HP:0000090)2.13020528
71Prolonged QT interval (HP:0001657)2.12447221
72Medial flaring of the eyebrow (HP:0010747)2.12335979
73Depression (HP:0000716)2.12236565
74Action tremor (HP:0002345)2.12158393
75Double outlet right ventricle (HP:0001719)2.11160875
76Congenital malformation of the right heart (HP:0011723)2.11160875
77Bifid tongue (HP:0010297)2.10302133
78Ventricular fibrillation (HP:0001663)2.10029954
79Preaxial hand polydactyly (HP:0001177)2.09727385
80Abnormality of cochlea (HP:0000375)2.09450176
81EEG with generalized epileptiform discharges (HP:0011198)2.09142011
82Albinism (HP:0001022)2.07870678
83Decreased central vision (HP:0007663)2.06618141
84Congenital primary aphakia (HP:0007707)2.05206540
85Abnormality of salivation (HP:0100755)2.02817743
86Growth hormone deficiency (HP:0000824)2.01056926
87Cupped ear (HP:0000378)2.00778416
88Abnormality of ocular smooth pursuit (HP:0000617)1.99242685
89Abnormality of the phalanges of the hallux (HP:0010057)1.98764537
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.98535247
91Renal dysplasia (HP:0000110)1.98469466
92Chronic hepatic failure (HP:0100626)1.98000644
93Colon cancer (HP:0003003)1.96903216
94Duplication of thumb phalanx (HP:0009942)1.96444326
95Blue irides (HP:0000635)1.96385607
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95788784
97Nephrogenic diabetes insipidus (HP:0009806)1.94061427
98Abnormality of the antihelix (HP:0009738)1.93962529
99Impaired vibration sensation in the lower limbs (HP:0002166)1.93481311
100Alacrima (HP:0000522)1.91673273
101Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.91124718
102Aplasia involving bones of the upper limbs (HP:0009823)1.90592184
103Aplasia of the phalanges of the hand (HP:0009802)1.90592184
104Aplasia involving bones of the extremities (HP:0009825)1.90592184
105Truncus arteriosus (HP:0001660)1.90407204
106Triphalangeal thumb (HP:0001199)1.90014125
107Megalencephaly (HP:0001355)1.89599100
108Incomplete penetrance (HP:0003829)1.89540895
109Abnormality of midbrain morphology (HP:0002418)1.88026825
110Molar tooth sign on MRI (HP:0002419)1.88026825
111Morphological abnormality of the inner ear (HP:0011390)1.87896959
112Omphalocele (HP:0001539)1.86254866
113Absent septum pellucidum (HP:0001331)1.85380071
114Anencephaly (HP:0002323)1.85096215
115Fetal akinesia sequence (HP:0001989)1.84557780
116Anxiety (HP:0000739)1.83487621
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.81961141
118Coronal craniosynostosis (HP:0004440)1.81267197
119Broad thumb (HP:0011304)1.80771396
120Labial hypoplasia (HP:0000066)1.80144119
121Absent eyebrow (HP:0002223)1.78755336
122Abnormality of the middle phalanges of the toes (HP:0010183)1.78568767
123Absent radius (HP:0003974)1.77881336
124Primary atrial arrhythmia (HP:0001692)1.77370963
125Abnormal EKG (HP:0003115)1.77027588
126Hypoventilation (HP:0002791)1.76903538
127Supranuclear gaze palsy (HP:0000605)1.76880847
128Bilateral microphthalmos (HP:0007633)1.76480662
129Postaxial hand polydactyly (HP:0001162)1.76414880
130Hypsarrhythmia (HP:0002521)1.76298098
131Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76096731
132Astrocytoma (HP:0009592)1.75795780
133Abnormality of the astrocytes (HP:0100707)1.75795780
134Pancreatic fibrosis (HP:0100732)1.75231068
135Abnormality of the septum pellucidum (HP:0007375)1.75209948
136Urinary bladder sphincter dysfunction (HP:0002839)1.74843689
137Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.74638188
138Atrial fibrillation (HP:0005110)1.74007225
139Intellectual disability, moderate (HP:0002342)1.73707593
140Ectopic kidney (HP:0000086)1.73595164
141Increased nuchal translucency (HP:0010880)1.73488641
142Keratoconus (HP:0000563)1.72990228
143Increased corneal curvature (HP:0100692)1.72990228
144Abnormality of the ischium (HP:0003174)1.72629645
145Absent forearm bone (HP:0003953)1.72521587
146Aplasia involving forearm bones (HP:0009822)1.72521587
147Mutism (HP:0002300)1.71879287
148Hemivertebrae (HP:0002937)1.71790882
149Postaxial foot polydactyly (HP:0001830)1.71753965
150Rhabdomyosarcoma (HP:0002859)1.71489243
151Chorioretinal coloboma (HP:0000567)1.70684135
152Unsteady gait (HP:0002317)1.70340444
153Generalized myoclonic seizures (HP:0002123)1.69489046
154Micropenis (HP:0000054)1.69393052
155Poor coordination (HP:0002370)1.69333420
156Abnormality of the pubic bones (HP:0003172)1.69037749
157Pancreatic cysts (HP:0001737)1.68682145
158Aplasia/Hypoplasia of the macula (HP:0008059)1.67030348
159Decreased lacrimation (HP:0000633)1.66194598
160Widely spaced teeth (HP:0000687)1.65850360
161Abnormality of the renal medulla (HP:0100957)1.65764750
162Generalized hypopigmentation (HP:0007513)1.65023010
163Syncope (HP:0001279)1.64908583
164Narrow nasal bridge (HP:0000446)1.64817587
165Autism (HP:0000717)1.64691672
166True hermaphroditism (HP:0010459)1.64547969
167Narrow forehead (HP:0000341)1.64101466
168Broad finger (HP:0001500)1.64096197
169Neoplasm of striated muscle (HP:0009728)1.64054935
170Facial hemangioma (HP:0000329)1.63943445
171Thickened helices (HP:0000391)1.63808104
172Hypoplastic female external genitalia (HP:0012815)1.63629038
173Open mouth (HP:0000194)1.63450665
174Supraventricular tachycardia (HP:0004755)1.63295760
175Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63098789
176Genital tract atresia (HP:0001827)1.63098067
177Supernumerary spleens (HP:0009799)1.63042413
178Hydroureter (HP:0000072)1.63002464
179Hyperkalemia (HP:0002153)1.62919607
180Maternal diabetes (HP:0009800)1.62840425
181Anophthalmia (HP:0000528)1.62656374
182Vaginal atresia (HP:0000148)1.61584291
183Congenital sensorineural hearing impairment (HP:0008527)1.60532194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.85494044
2NTRK34.92986994
3FGFR22.90154850
4CASK2.76325104
5TNIK2.64811966
6PRPF4B2.61471195
7MAP2K72.37372585
8MARK12.27015339
9PAK62.25942977
10KSR12.24963257
11MAP3K42.24205072
12SRPK12.13968548
13MINK12.12653838
14EPHB22.00832569
15RIPK41.92861242
16MAP3K91.87942737
17PLK21.87265671
18STK161.77530508
19CAMK1G1.73008597
20NTRK21.72995598
21TRIM281.61725899
22PLK41.59280711
23MARK21.58481751
24MAP3K101.57835174
25TAOK21.56325130
26MKNK11.55919636
27KSR21.55744993
28CLK11.55531916
29MAP4K21.54345666
30BMPR1B1.53123652
31DYRK1A1.52608227
32DYRK21.48724584
33CDC71.48645268
34DAPK21.44836546
35WEE11.41475400
36MAP3K71.41386897
37SIK31.39634326
38MAPK131.37036143
39CAMK2B1.36358181
40DAPK11.32127768
41TAF11.30887013
42CAMK11.29203687
43EPHA31.27933279
44PRKCG1.27694397
45CAMK2A1.24954369
46CDK51.19684445
47PTK2B1.19325133
48BMPR21.16336515
49ACVR1B1.13631272
50STK381.12491248
51MAP2K41.10979743
52CDK81.09377197
53FES1.09359165
54VRK11.07380324
55AKT31.06753617
56PKN21.06096041
57INSRR1.04923799
58PHKG21.04681778
59PHKG11.04681778
60FRK1.03546483
61STK38L1.02424669
62OBSCN1.01630702
63FGFR11.00247675
64CSNK1G10.99633648
65ERBB30.99104830
66CSNK1G20.98677465
67CDK30.98111175
68TGFBR10.97269008
69TNK20.96794493
70SIK20.95364223
71CAMK1D0.95224420
72CSNK1A1L0.93682861
73CSNK1G30.92643108
74MAP3K130.90871311
75GRK50.89419738
76LATS10.88823682
77RAF10.87920281
78CDK180.86580147
79PRKD30.86270571
80CAMKK10.82061864
81CAMKK20.80416930
82CDK150.79026283
83NME10.77657283
84CAMK2D0.76147005
85DYRK30.74956477
86CDK140.74466310
87SGK20.73900970
88PRKCE0.73521167
89CCNB10.71651036
90ARAF0.71407172
91MAP3K20.71376734
92MAP3K120.70075636
93SGK2230.70006303
94SGK4940.70006303
95SGK10.69121775
96FER0.68774361
97CDK11A0.68370790
98ATR0.65571912
99PAK30.65168335
100MKNK20.64203828
101ATM0.64094379
102CHEK20.63595843
103BUB10.62642389
104TYRO30.61895022
105WNK30.61534642
106CDK190.59465041
107BRSK20.59042688
108TTK0.58222293
109BCR0.55827084
110CAMK40.55269495
111PNCK0.53733815
112PLK10.53378924
113NUAK10.52750586
114UHMK10.51318528
115PLK30.50032865
116DMPK0.49420242
117PRKDC0.49089864
118LATS20.48740486
119PRKG10.48483017
120CDK120.47231893
121LMTK20.47150392
122FLT30.47099629
123FGR0.46787982
124DDR20.46628724
125NTRK10.46600229
126MAPK100.46544100
127PRKACA0.46324541
128RPS6KA30.46074652
129CDC42BPA0.45906657
130CSNK1E0.45480440
131PKN10.44918958
132ZAK0.44305077
133GRK10.44158883
134PASK0.43106925
135NEK10.42943789
136PRKAA20.42648417
137STK110.41876653
138BRD40.41569786
139CSNK1D0.41436250
140PRKACB0.41303079
141CAMK2G0.41042594
142GRK70.40981660
143PRKCA0.40940940
144CHEK10.40283828
145BRAF0.39943221
146CDK10.39334908
147FYN0.39193546
148ADRBK20.38862262
149PRKCZ0.38665947
150NEK60.38450544
151SGK30.37620120
152MAPK150.37585486
153AURKB0.36635250
154PIK3CA0.35828096
155CDK20.34521959
156GSK3B0.34404995

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.23917968
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.30633653
3Circadian entrainment_Homo sapiens_hsa047133.12353333
4GABAergic synapse_Homo sapiens_hsa047273.10805427
5Synaptic vesicle cycle_Homo sapiens_hsa047212.93047174
6Morphine addiction_Homo sapiens_hsa050322.88208408
7Glutamatergic synapse_Homo sapiens_hsa047242.66563723
8Long-term potentiation_Homo sapiens_hsa047202.62338855
9Amphetamine addiction_Homo sapiens_hsa050312.42144987
10Olfactory transduction_Homo sapiens_hsa047402.34786313
11Salivary secretion_Homo sapiens_hsa049702.14114490
12Insulin secretion_Homo sapiens_hsa049112.09271924
13Dopaminergic synapse_Homo sapiens_hsa047282.07023848
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.05794998
15Fanconi anemia pathway_Homo sapiens_hsa034601.99969263
16Renin secretion_Homo sapiens_hsa049241.99882645
17Calcium signaling pathway_Homo sapiens_hsa040201.95854379
18Oxytocin signaling pathway_Homo sapiens_hsa049211.94867107
19Serotonergic synapse_Homo sapiens_hsa047261.93428135
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91310380
21Mismatch repair_Homo sapiens_hsa034301.90745510
22Non-homologous end-joining_Homo sapiens_hsa034501.90114391
23Cholinergic synapse_Homo sapiens_hsa047251.89341930
24Taste transduction_Homo sapiens_hsa047421.85970679
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84337372
26Long-term depression_Homo sapiens_hsa047301.74396730
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68165526
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63238494
29Steroid biosynthesis_Homo sapiens_hsa001001.63166322
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61011210
31cAMP signaling pathway_Homo sapiens_hsa040241.52916013
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52040125
33TGF-beta signaling pathway_Homo sapiens_hsa043501.45198164
34Collecting duct acid secretion_Homo sapiens_hsa049661.42228799
35Homologous recombination_Homo sapiens_hsa034401.41988789
36Cardiac muscle contraction_Homo sapiens_hsa042601.41577894
37Cell cycle_Homo sapiens_hsa041101.38596777
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33884363
39Gastric acid secretion_Homo sapiens_hsa049711.32929222
40Cocaine addiction_Homo sapiens_hsa050301.32531455
41DNA replication_Homo sapiens_hsa030301.31833733
42Spliceosome_Homo sapiens_hsa030401.31180691
43GnRH signaling pathway_Homo sapiens_hsa049121.29234974
44Propanoate metabolism_Homo sapiens_hsa006401.26578532
45* Axon guidance_Homo sapiens_hsa043601.25837395
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25192486
47Basal transcription factors_Homo sapiens_hsa030221.23826726
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22609426
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21169981
50Dilated cardiomyopathy_Homo sapiens_hsa054141.21079402
51Gap junction_Homo sapiens_hsa045401.20882245
52Circadian rhythm_Homo sapiens_hsa047101.18249672
53Phototransduction_Homo sapiens_hsa047441.16736302
54mRNA surveillance pathway_Homo sapiens_hsa030151.12006259
55Protein export_Homo sapiens_hsa030601.11801678
56Base excision repair_Homo sapiens_hsa034101.10659042
57Vascular smooth muscle contraction_Homo sapiens_hsa042701.07057549
58Lysine degradation_Homo sapiens_hsa003101.05632969
59RNA transport_Homo sapiens_hsa030131.05312657
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00125628
61RNA degradation_Homo sapiens_hsa030180.99053268
62RNA polymerase_Homo sapiens_hsa030200.98427003
63Nucleotide excision repair_Homo sapiens_hsa034200.96192533
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95496502
65Vibrio cholerae infection_Homo sapiens_hsa051100.94647127
66Type II diabetes mellitus_Homo sapiens_hsa049300.94091610
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93216080
68Melanogenesis_Homo sapiens_hsa049160.89719634
69Parkinsons disease_Homo sapiens_hsa050120.89093398
70Tight junction_Homo sapiens_hsa045300.88809663
71Huntingtons disease_Homo sapiens_hsa050160.87885454
72Butanoate metabolism_Homo sapiens_hsa006500.85531308
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84668235
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77226628
75Glioma_Homo sapiens_hsa052140.76154103
76Oxidative phosphorylation_Homo sapiens_hsa001900.75374374
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75274409
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73975007
79Estrogen signaling pathway_Homo sapiens_hsa049150.73672427
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73308081
81Pancreatic secretion_Homo sapiens_hsa049720.72900078
82MicroRNAs in cancer_Homo sapiens_hsa052060.72002945
83Protein digestion and absorption_Homo sapiens_hsa049740.69216380
84Oocyte meiosis_Homo sapiens_hsa041140.68579660
85Choline metabolism in cancer_Homo sapiens_hsa052310.67575427
86ErbB signaling pathway_Homo sapiens_hsa040120.67372021
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66983879
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66967229
89MAPK signaling pathway_Homo sapiens_hsa040100.65838268
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63169352
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62824164
92Pathways in cancer_Homo sapiens_hsa052000.61989443
93Wnt signaling pathway_Homo sapiens_hsa043100.61156598
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.60562048
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60523136
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.59209566
97Nitrogen metabolism_Homo sapiens_hsa009100.54597491
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54448207
99Thyroid hormone synthesis_Homo sapiens_hsa049180.54226073
100Rap1 signaling pathway_Homo sapiens_hsa040150.53818971
101Alcoholism_Homo sapiens_hsa050340.52861607
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52743699
103Glucagon signaling pathway_Homo sapiens_hsa049220.52091792
104Pyruvate metabolism_Homo sapiens_hsa006200.51046885
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49735745
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49029121
107Prostate cancer_Homo sapiens_hsa052150.48687250
108Ras signaling pathway_Homo sapiens_hsa040140.47966063
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47340284
110Inositol phosphate metabolism_Homo sapiens_hsa005620.46848694
111Ribosome_Homo sapiens_hsa030100.46182219
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45367519
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45302345
114Notch signaling pathway_Homo sapiens_hsa043300.45141871
115Purine metabolism_Homo sapiens_hsa002300.43732986
116Alzheimers disease_Homo sapiens_hsa050100.43697150
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43630573
118Mineral absorption_Homo sapiens_hsa049780.43597072
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43352342
120ECM-receptor interaction_Homo sapiens_hsa045120.42515912
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41008655
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.40001925
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39817429
124African trypanosomiasis_Homo sapiens_hsa051430.37451356
125Adherens junction_Homo sapiens_hsa045200.35537616
126Melanoma_Homo sapiens_hsa052180.33844443
127VEGF signaling pathway_Homo sapiens_hsa043700.33241379
128Ovarian steroidogenesis_Homo sapiens_hsa049130.28176994
129Fructose and mannose metabolism_Homo sapiens_hsa000510.27119283
130Colorectal cancer_Homo sapiens_hsa052100.27077872
131Endometrial cancer_Homo sapiens_hsa052130.26374404
132Hedgehog signaling pathway_Homo sapiens_hsa043400.25919606
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23754872
134Dorso-ventral axis formation_Homo sapiens_hsa043200.23002969
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19440414
136Hippo signaling pathway_Homo sapiens_hsa043900.18376953
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18155378
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18115270
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16389242
140mTOR signaling pathway_Homo sapiens_hsa041500.15846656
141Renal cell carcinoma_Homo sapiens_hsa052110.15811828
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.13841251
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13482923
144Non-small cell lung cancer_Homo sapiens_hsa052230.13092529
145Rheumatoid arthritis_Homo sapiens_hsa053230.12493173
146Basal cell carcinoma_Homo sapiens_hsa052170.12313361

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