EPHA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)8.28845110
2regulation of posttranscriptional gene silencing (GO:0060147)8.28845110
3regulation of gene silencing by miRNA (GO:0060964)8.28845110
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.71291107
5L-phenylalanine catabolic process (GO:0006559)6.71291107
6L-phenylalanine metabolic process (GO:0006558)6.50613711
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.50613711
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.32820947
9aromatic amino acid family catabolic process (GO:0009074)6.01212028
10L-serine metabolic process (GO:0006563)5.93712120
11L-alpha-amino acid transmembrane transport (GO:1902475)5.71413038
12pre-miRNA processing (GO:0031054)5.58212671
13kynurenine metabolic process (GO:0070189)5.46647553
14indole-containing compound catabolic process (GO:0042436)5.45128276
15indolalkylamine catabolic process (GO:0046218)5.45128276
16tryptophan catabolic process (GO:0006569)5.45128276
17high-density lipoprotein particle remodeling (GO:0034375)5.44831677
18urea cycle (GO:0000050)5.39512924
19urea metabolic process (GO:0019627)5.39512924
20negative regulation of fibrinolysis (GO:0051918)5.20909857
21bile acid biosynthetic process (GO:0006699)5.20654367
22glyoxylate metabolic process (GO:0046487)5.16927723
23tryptophan metabolic process (GO:0006568)5.14979533
24cysteine metabolic process (GO:0006534)5.11308226
25alpha-linolenic acid metabolic process (GO:0036109)5.07532607
26peptidyl-glutamic acid carboxylation (GO:0017187)5.04926608
27protein carboxylation (GO:0018214)5.04926608
28sulfur amino acid catabolic process (GO:0000098)5.03092516
29phospholipid efflux (GO:0033700)4.99273815
30regulation of cell fate specification (GO:0042659)4.96548259
31regulation of cholesterol esterification (GO:0010872)4.96391529
32regulation of triglyceride catabolic process (GO:0010896)4.93462907
33regulation of fibrinolysis (GO:0051917)4.92645548
34positive regulation of SMAD protein import into nucleus (GO:0060391)4.92579916
35nitrogen cycle metabolic process (GO:0071941)4.90573099
36reverse cholesterol transport (GO:0043691)4.86138295
37regulation of protein activation cascade (GO:2000257)4.85132609
38complement activation, alternative pathway (GO:0006957)4.79733438
39establishment of integrated proviral latency (GO:0075713)4.77128979
40homocysteine metabolic process (GO:0050667)4.71509178
41negative regulation of sterol transport (GO:0032372)4.70237288
42negative regulation of cholesterol transport (GO:0032375)4.70237288
43regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.68081539
44protein-lipid complex remodeling (GO:0034368)4.63421193
45macromolecular complex remodeling (GO:0034367)4.63421193
46plasma lipoprotein particle remodeling (GO:0034369)4.63421193
47serine family amino acid catabolic process (GO:0009071)4.62820062
48protein complex localization (GO:0031503)4.56576399
49bile acid metabolic process (GO:0008206)4.54037520
50regulation of complement activation (GO:0030449)4.53393131
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.49003451
52heterochromatin organization (GO:0070828)4.41957318
53acylglycerol homeostasis (GO:0055090)4.41286201
54triglyceride homeostasis (GO:0070328)4.41286201
55intestinal cholesterol absorption (GO:0030299)4.39711300
56amino-acid betaine metabolic process (GO:0006577)4.36546514
57aromatic amino acid family metabolic process (GO:0009072)4.34379550
58cholesterol efflux (GO:0033344)4.29845051
59cellular glucuronidation (GO:0052695)4.28433708
60lysine metabolic process (GO:0006553)4.28143794
61lysine catabolic process (GO:0006554)4.28143794
62plasma lipoprotein particle clearance (GO:0034381)4.26493494
63regulation of gene silencing (GO:0060968)4.24598330
64paraxial mesoderm development (GO:0048339)4.24023199
65tyrosine metabolic process (GO:0006570)4.21208309
66plasma lipoprotein particle assembly (GO:0034377)4.20074506
67bile acid and bile salt transport (GO:0015721)4.17658397
68glycine metabolic process (GO:0006544)4.13464241
69imidazole-containing compound metabolic process (GO:0052803)4.12697053
70positive regulation of triglyceride lipase activity (GO:0061365)4.10434333
71positive regulation of lipoprotein lipase activity (GO:0051006)4.10434333
72drug catabolic process (GO:0042737)4.09815382
73alpha-amino acid catabolic process (GO:1901606)4.09751310
74regulation of cholesterol homeostasis (GO:2000188)4.07675240
75fibrinolysis (GO:0042730)4.00933380
76negative regulation of gene silencing (GO:0060969)3.99226918
77regulation of histone H3-K9 methylation (GO:0051570)3.94558772
78negative regulation of translation, ncRNA-mediated (GO:0040033)3.93607720
79regulation of translation, ncRNA-mediated (GO:0045974)3.93607720
80negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.93607720
81cholesterol homeostasis (GO:0042632)3.91791543
82serine family amino acid metabolic process (GO:0009069)3.90660830
83regulation of bile acid biosynthetic process (GO:0070857)3.87984879
84glutamate metabolic process (GO:0006536)3.87161194
85sterol homeostasis (GO:0055092)3.86496593
86regulation of helicase activity (GO:0051095)3.84857637
87bundle of His cell to Purkinje myocyte communication (GO:0086069)3.83535083
88lipoprotein metabolic process (GO:0042157)3.82500912
89very-low-density lipoprotein particle assembly (GO:0034379)3.81927371
90uronic acid metabolic process (GO:0006063)3.81723101
91glucuronate metabolic process (GO:0019585)3.81723101
92lung-associated mesenchyme development (GO:0060484)3.81534415
93protein-lipid complex assembly (GO:0065005)3.81115928
94nuclear pore complex assembly (GO:0051292)3.81072549
95protein localization to kinetochore (GO:0034501)3.80743126
96positive regulation of lipid catabolic process (GO:0050996)3.79354882
97benzene-containing compound metabolic process (GO:0042537)3.78761060
98ethanol oxidation (GO:0006069)3.77249975
99serine family amino acid biosynthetic process (GO:0009070)3.76849743
100indolalkylamine metabolic process (GO:0006586)3.76792717
101cellular amino acid catabolic process (GO:0009063)3.76397236
102cellular modified amino acid catabolic process (GO:0042219)3.75596533
103flavonoid metabolic process (GO:0009812)3.72581867
104amine catabolic process (GO:0009310)3.71809068
105cellular biogenic amine catabolic process (GO:0042402)3.71809068
106positive regulation of catenin import into nucleus (GO:0035413)3.70069352
107phospholipid homeostasis (GO:0055091)3.68376063
108regulation of chromatin silencing (GO:0031935)3.66847410
109arginine metabolic process (GO:0006525)3.66029995
110cellular ketone body metabolic process (GO:0046950)3.65535331
111negative regulation of lipase activity (GO:0060192)3.63851821
112plasma lipoprotein particle organization (GO:0071827)3.60958925
113response to nitrosative stress (GO:0051409)3.60755881
114establishment of apical/basal cell polarity (GO:0035089)3.59870645
115dicarboxylic acid biosynthetic process (GO:0043650)3.59123968
116aldehyde catabolic process (GO:0046185)3.54590898
117negative regulation of cell fate specification (GO:0009996)3.54582218
118DNA replication-dependent nucleosome assembly (GO:0006335)3.54081367
119DNA replication-dependent nucleosome organization (GO:0034723)3.54081367
120intestinal absorption (GO:0050892)3.53918548
121low-density lipoprotein particle remodeling (GO:0034374)3.52388445
122regulation of SMAD protein import into nucleus (GO:0060390)3.51041784
123regulation of cell fate commitment (GO:0010453)3.48561293
124coenzyme catabolic process (GO:0009109)3.47827898
125establishment of viral latency (GO:0019043)3.47690764
126dorsal/ventral axis specification (GO:0009950)3.46778356
127protein-lipid complex subunit organization (GO:0071825)3.42151724
128IMP biosynthetic process (GO:0006188)3.41547165
129single strand break repair (GO:0000012)3.41376672
130nuclear pore organization (GO:0006999)3.40983698
131drug metabolic process (GO:0017144)3.40081479
132positive regulation of fatty acid beta-oxidation (GO:0032000)3.36651119
133acute-phase response (GO:0006953)3.35350955
134cell fate commitment involved in formation of primary germ layer (GO:0060795)3.34509640
135blood coagulation, intrinsic pathway (GO:0007597)3.34098759
136protein activation cascade (GO:0072376)3.33580256
137negative regulation of telomerase activity (GO:0051974)3.33162047
138positive regulation of triglyceride metabolic process (GO:0090208)3.32683012
139gap junction assembly (GO:0016264)3.32355780
140complement activation (GO:0006956)3.32312721
141negative regulation of cell fate commitment (GO:0010454)3.28798454
142somatic hypermutation of immunoglobulin genes (GO:0016446)3.28717194
143somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28717194
144glomerular visceral epithelial cell development (GO:0072015)3.26820097
145histone arginine methylation (GO:0034969)3.25362709
146cellular protein complex localization (GO:0034629)3.23002683
147regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22966867
148regulation of mitotic spindle checkpoint (GO:1903504)3.22966867
149IMP metabolic process (GO:0046040)3.19568651
150telomere maintenance via telomerase (GO:0007004)3.16256424
151DNA unwinding involved in DNA replication (GO:0006268)3.16111354
152chromatin remodeling at centromere (GO:0031055)3.14287523
153negative regulation of histone methylation (GO:0031061)3.13987372
154regulation of nuclear cell cycle DNA replication (GO:0033262)3.10307036
155nucleobase biosynthetic process (GO:0046112)3.10254176
156DNA strand elongation involved in DNA replication (GO:0006271)3.09263021
157anterior/posterior axis specification, embryo (GO:0008595)3.08417963
158regulation of telomere maintenance via telomerase (GO:0032210)3.08225010
159convergent extension (GO:0060026)3.02550469
160establishment of monopolar cell polarity (GO:0061162)2.96448676
161establishment or maintenance of monopolar cell polarity (GO:0061339)2.96448676
162regulation of stem cell maintenance (GO:2000036)2.96115592
163negative regulation of mitotic sister chromatid separation (GO:2000816)2.95131654
164negative regulation of sister chromatid segregation (GO:0033046)2.95131654
165negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95131654
166negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95131654
167negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95131654
168nodal signaling pathway (GO:0038092)2.93277081
169DNA strand elongation (GO:0022616)2.91994706
170DNA replication checkpoint (GO:0000076)2.91873370
171negative regulation of chromosome segregation (GO:0051985)2.91756283
172CENP-A containing nucleosome assembly (GO:0034080)2.91093118
173negative regulation of androgen receptor signaling pathway (GO:0060766)2.88518684
174purine nucleobase biosynthetic process (GO:0009113)2.85713505
175negative regulation of DNA-dependent DNA replication (GO:2000104)2.82826747
176notochord development (GO:0030903)2.82558713
177histone exchange (GO:0043486)2.82336817
178chromatin assembly (GO:0031497)2.79742982
179glomerular epithelial cell development (GO:0072310)2.77613138
180regulation of translational fidelity (GO:0006450)2.74748442
181glutamine metabolic process (GO:0006541)2.73368587
182DNA replication-independent nucleosome assembly (GO:0006336)2.73342698
183DNA replication-independent nucleosome organization (GO:0034724)2.73342698
184ribosome assembly (GO:0042255)2.72685118
185nucleotide-sugar biosynthetic process (GO:0009226)2.72525145
186ncRNA catabolic process (GO:0034661)2.71465934
187RNA-dependent DNA replication (GO:0006278)2.70863812
188regulation of chromosome segregation (GO:0051983)2.70631000
189regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.70300886
190basic amino acid transport (GO:0015802)2.67626055
191protein localization to chromosome, centromeric region (GO:0071459)2.67246780
192planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67106930
193DNA damage response, detection of DNA damage (GO:0042769)2.66322721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.41115591
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.23625220
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.45929020
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.83717647
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.68344187
6TP63_17297297_ChIP-ChIP_HaCaT_Human5.09225105
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47451091
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.40689405
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.27258382
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.55677219
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.55677219
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.55677219
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.48715179
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.48683756
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.06094196
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84703333
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80308912
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78791769
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67838622
20NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.60680274
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60413389
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.33773931
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32376160
24* NANOG_16153702_ChIP-ChIP_HESCs_Human2.23801624
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.22062869
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18922557
27CLOCK_20551151_ChIP-Seq_293T_Human2.15475875
28* SOX2_16153702_ChIP-ChIP_HESCs_Human2.10625085
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.08680060
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08196318
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04728928
32* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.03152593
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01157059
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2812109
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99308216
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98179306
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95611692
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.93039035
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88311287
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84531860
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81571324
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.76265107
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74924917
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73113855
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71157513
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.69579731
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68938739
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68744529
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67318842
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61579938
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.60840407
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58590863
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55820147
54GATA4_25053715_ChIP-Seq_YYC3_Human1.47240283
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.46694387
56* FOXA2_19822575_ChIP-Seq_HepG2_Human1.46249885
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43302671
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41747562
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41612303
60ZNF263_19887448_ChIP-Seq_K562_Human1.40821213
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.38916399
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36219523
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35584920
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29195043
65GATA1_22025678_ChIP-Seq_K562_Human1.29124788
66* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28343337
67FOXP3_21729870_ChIP-Seq_TREG_Human1.27229917
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27067355
69CDX2_20551321_ChIP-Seq_CACO-2_Human1.26389451
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.25061241
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24640677
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24129962
73* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.23093128
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.22806037
75* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22090562
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19428560
77GATA6_25053715_ChIP-Seq_YYC3_Human1.18897471
78* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17822440
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17252439
80* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16871992
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.16830717
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16625475
83KAP1_27257070_Chip-Seq_ESCs_Mouse1.16576985
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15602493
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14681066
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14470548
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14146082
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12104274
89* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12009980
90XRN2_22483619_ChIP-Seq_HELA_Human1.10075792
91TRIM28_21343339_ChIP-Seq_HEK293_Human1.09701981
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09670129
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09429807
94* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08622204
95* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06623315
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06015475
97GABP_17652178_ChIP-ChIP_JURKAT_Human1.05026575
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04897508
99TTF2_22483619_ChIP-Seq_HELA_Human1.04644597
100IRF1_19129219_ChIP-ChIP_H3396_Human1.03777584
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02943247
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02856736
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02359705
104POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02173014
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01689158
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01524136
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01501242
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01458881
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01188848
110SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01140335
111RACK7_27058665_Chip-Seq_MCF-7_Human1.01001503
112RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00329036
113MYC_18940864_ChIP-ChIP_HL60_Human0.99760197
114* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99293451
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98311567
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98230064
117ETS1_20019798_ChIP-Seq_JURKAT_Human0.98154067
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97897950
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97525442
120CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97296728
121PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96642868
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96034503
123ELK1_19687146_ChIP-ChIP_HELA_Human0.94571809
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94471736
125CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93455164
126DCP1A_22483619_ChIP-Seq_HELA_Human0.93410664
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92925706
128* SOX2_20726797_ChIP-Seq_SW620_Human0.92476656
129YY1_21170310_ChIP-Seq_MESCs_Mouse0.91649000
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90995156
131CHD1_26751641_Chip-Seq_LNCaP_Human0.90981650
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90572360
133* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90428499
134* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90204696
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89012871
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88730314
137ATF3_27146783_Chip-Seq_COLON_Human0.88647627
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88083155
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86489976
140* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85331759
141LXR_22292898_ChIP-Seq_THP-1_Human0.83228069
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81676303
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81676303
144* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81554260
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.81430308
146ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80676558
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79726239
148HTT_18923047_ChIP-ChIP_STHdh_Human0.79527742
149* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77175767
150IRF8_22096565_ChIP-ChIP_GC-B_Human0.76821052
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.76657280
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72087988
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71013481
154CEBPB_22108803_ChIP-Seq_LS180_Human0.70389265
155* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69118729
156BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68620703
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.67799023
158AR_21909140_ChIP-Seq_LNCAP_Human0.67201493
159AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64056453
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.62792291
161RARA_24833708_ChIP-Seq_LIVER_Mouse0.62620953
162FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60321164
163SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59056304
164RUNX1_27514584_Chip-Seq_MCF-7_Human0.58884631
165* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.58205610
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56995070
167* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.55956135
168EGR1_19032775_ChIP-ChIP_M12_Human0.55943486
169RARB_24833708_ChIP-Seq_LIVER_Mouse0.54599120
170SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.54395437
171* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.53584973
172NRF2_20460467_ChIP-Seq_MEFs_Mouse0.53564641
173NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.53564641
174ELK3_25401928_ChIP-Seq_HUVEC_Human0.52397891
175TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.52304247
176* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.52284547
177BCOR_27268052_Chip-Seq_Bcells_Human0.51814200
178CREB1_26743006_Chip-Seq_LNCaP_Human0.51443728
179KAP1_22055183_ChIP-Seq_ESCs_Mouse0.51279701
180TP63_23658742_ChIP-Seq_EP156T_Human0.51137435
181SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.50839308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.26965212
2MP0005360_urolithiasis7.23577122
3MP0005085_abnormal_gallbladder_physiolo5.66050621
4MP0005365_abnormal_bile_salt5.13087734
5MP0008875_abnormal_xenobiotic_pharmacok4.46992425
6MP0003693_abnormal_embryo_hatching3.82857866
7MP0003806_abnormal_nucleotide_metabolis3.70020044
8MP0003252_abnormal_bile_duct3.67691665
9MP0010329_abnormal_lipoprotein_level3.27888678
10MP0004957_abnormal_blastocyst_morpholog3.25256117
11MP0009840_abnormal_foam_cell3.22654504
12MP0001666_abnormal_nutrient_absorption3.04225357
13MP0008877_abnormal_DNA_methylation2.75478491
14MP0005083_abnormal_biliary_tract2.67628181
15MP0003890_abnormal_embryonic-extraembry2.57115446
16MP0003705_abnormal_hypodermis_morpholog2.51538490
17MP0003111_abnormal_nucleus_morphology2.47728804
18MP0003191_abnormal_cellular_cholesterol2.41878882
19MP0010094_abnormal_chromosome_stability2.39746389
20MP0005332_abnormal_amino_acid2.37216538
21MP0003878_abnormal_ear_physiology2.31681533
22MP0005377_hearing/vestibular/ear_phenot2.31681533
23MP0008057_abnormal_DNA_replication2.30967129
24MP0002796_impaired_skin_barrier2.22676810
25MP0004019_abnormal_vitamin_homeostasis2.20401485
26MP0008058_abnormal_DNA_repair2.18582516
27MP0010234_abnormal_vibrissa_follicle2.05893149
28MP0003195_calcinosis1.98484028
29MP0001293_anophthalmia1.92735610
30MP0000609_abnormal_liver_physiology1.91448962
31MP0001730_embryonic_growth_arrest1.86874279
32MP0008932_abnormal_embryonic_tissue1.86010110
33MP0003077_abnormal_cell_cycle1.75502674
34MP0002118_abnormal_lipid_homeostasis1.74575185
35MP0002138_abnormal_hepatobiliary_system1.71475569
36MP0000579_abnormal_nail_morphology1.66289273
37MP0003119_abnormal_digestive_system1.65691442
38MP0003937_abnormal_limbs/digits/tail_de1.63553315
39MP0006292_abnormal_olfactory_placode1.60163309
40MP0005319_abnormal_enzyme/_coenzyme1.58576141
41MP0004133_heterotaxia1.58246106
42MP0003567_abnormal_fetal_cardiomyocyte1.56026488
43MP0003136_yellow_coat_color1.46870744
44MP0002085_abnormal_embryonic_tissue1.46475393
45MP0009703_decreased_birth_body1.45608963
46MP0002697_abnormal_eye_size1.43973316
47MP0001188_hyperpigmentation1.43490591
48MP0009053_abnormal_anal_canal1.42611952
49MP0005275_abnormal_skin_tensile1.39372176
50MP0001672_abnormal_embryogenesis/_devel1.38931177
51MP0005380_embryogenesis_phenotype1.38931177
52MP0002084_abnormal_developmental_patter1.38454167
53MP0000678_abnormal_parathyroid_gland1.37991866
54MP0005451_abnormal_body_composition1.37407256
55MP0003868_abnormal_feces_composition1.34652253
56MP0002098_abnormal_vibrissa_morphology1.30437099
57MP0003787_abnormal_imprinting1.30016029
58MP0003123_paternal_imprinting1.27321129
59MP0005501_abnormal_skin_physiology1.27286928
60* MP0002111_abnormal_tail_morphology1.25375379
61MP0009643_abnormal_urine_homeostasis1.19959807
62MP0003984_embryonic_growth_retardation1.19417779
63MP0002060_abnormal_skin_morphology1.19295157
64MP0001697_abnormal_embryo_size1.17520871
65MP0002088_abnormal_embryonic_growth/wei1.16679855
66MP0000350_abnormal_cell_proliferation1.16469046
67MP0004197_abnormal_fetal_growth/weight/1.16415967
68MP0003186_abnormal_redox_activity1.16160062
69MP0001764_abnormal_homeostasis1.16052389
70MP0009697_abnormal_copulation1.14431466
71MP0001485_abnormal_pinna_reflex1.14173286
72MP0005584_abnormal_enzyme/coenzyme_acti1.11060534
73MP0003453_abnormal_keratinocyte_physiol1.09530814
74MP0003011_delayed_dark_adaptation1.08594486
75MP0000598_abnormal_liver_morphology1.06988568
76MP0002080_prenatal_lethality1.05932663
77MP0002938_white_spotting1.02033910
78MP0004264_abnormal_extraembryonic_tissu1.02032815
79MP0001216_abnormal_epidermal_layer0.99273459
80MP0001286_abnormal_eye_development0.97471765
81MP0002086_abnormal_extraembryonic_tissu0.95982823
82MP0010368_abnormal_lymphatic_system0.94671252
83MP0000432_abnormal_head_morphology0.94413816
84MP0002089_abnormal_postnatal_growth/wei0.89082356
85MP0010678_abnormal_skin_adnexa0.88916174
86MP0000377_abnormal_hair_follicle0.88891188
87MP0000427_abnormal_hair_cycle0.88684375
88MP0006035_abnormal_mitochondrial_morpho0.88559157
89MP0004947_skin_inflammation0.88183531
90MP0009764_decreased_sensitivity_to0.88005522
91MP0003941_abnormal_skin_development0.87236053
92MP0003121_genomic_imprinting0.86181277
93MP0010307_abnormal_tumor_latency0.86174141
94MP0008007_abnormal_cellular_replicative0.86021507
95MP0000647_abnormal_sebaceous_gland0.85435768
96MP0000049_abnormal_middle_ear0.83662441
97MP0009763_increased_sensitivity_to0.82896248
98MP0003566_abnormal_cell_adhesion0.81995455
99MP0000467_abnormal_esophagus_morphology0.81858947
100MP0005408_hypopigmentation0.81241240
101MP0000428_abnormal_craniofacial_morphol0.80241683
102MP0002233_abnormal_nose_morphology0.77839766
103MP0005647_abnormal_sex_gland0.76343848
104MP0005023_abnormal_wound_healing0.75414867
105MP0001243_abnormal_dermal_layer0.74696426
106MP0003656_abnormal_erythrocyte_physiolo0.73864155
107MP0000604_amyloidosis0.72403986
108MP0005636_abnormal_mineral_homeostasis0.72146110
109MP0008469_abnormal_protein_level0.71626969
110MP0005410_abnormal_fertilization0.71017377
111MP0000627_abnormal_mammary_gland0.70946626
112* MP0002254_reproductive_system_inflammat0.70895576
113MP0003861_abnormal_nervous_system0.70838464
114MP0000490_abnormal_crypts_of0.70038587
115MP0000383_abnormal_hair_follicle0.69949834
116MP0000313_abnormal_cell_death0.69241425
117MP0009642_abnormal_blood_homeostasis0.68018227
118MP0005084_abnormal_gallbladder_morpholo0.67985695
119MP0005076_abnormal_cell_differentiation0.67962784
120MP0000470_abnormal_stomach_morphology0.67209400
121MP0004233_abnormal_muscle_weight0.66497409
122MP0009384_cardiac_valve_regurgitation0.65202087
123MP0005248_abnormal_Harderian_gland0.64208439
124MP0009765_abnormal_xenobiotic_induced0.64120425
125MP0010771_integument_phenotype0.64106811
126MP0009931_abnormal_skin_appearance0.62971640
127MP0004381_abnormal_hair_follicle0.61254581
128MP0010352_gastrointestinal_tract_polyps0.61167983
129MP0002136_abnormal_kidney_physiology0.61073360
130MP0005376_homeostasis/metabolism_phenot0.59652025
131MP0001756_abnormal_urination0.58827033
132MP0003436_decreased_susceptibility_to0.58795530
133MP0000566_synostosis0.58641359
134MP0002971_abnormal_brown_adipose0.56472286
135MP0005220_abnormal_exocrine_pancreas0.56171935
136MP0010030_abnormal_orbit_morphology0.54155858
137MP0004782_abnormal_surfactant_physiolog0.52153076
138MP0003718_maternal_effect0.51762477
139MP0001849_ear_inflammation0.50972907
140MP0005266_abnormal_metabolism0.50906386
141MP0005395_other_phenotype0.50865695
142MP0009672_abnormal_birth_weight0.50715801
143MP0003300_gastrointestinal_ulcer0.49561349
144MP0000367_abnormal_coat/_hair0.47887871
145MP0001191_abnormal_skin_condition0.47824518
146MP0005334_abnormal_fat_pad0.46920616
147MP0000537_abnormal_urethra_morphology0.45647657
148MP0002078_abnormal_glucose_homeostasis0.45285020
149MP0000538_abnormal_urinary_bladder0.45009938
150MP0005666_abnormal_adipose_tissue0.42688677
151MP0000762_abnormal_tongue_morphology0.42140761
152MP0003724_increased_susceptibility_to0.42020745
153MP0004185_abnormal_adipocyte_glucose0.41315139
154MP0001881_abnormal_mammary_gland0.41125870
155MP0005448_abnormal_energy_balance0.41052652
156MP0005670_abnormal_white_adipose0.41005004
157MP0001853_heart_inflammation0.40047382
158MP0001661_extended_life_span0.39888740

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.95963079
2Deep venous thrombosis (HP:0002625)6.78925450
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.73336319
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.37807288
5Hypobetalipoproteinemia (HP:0003563)6.34811902
6Xanthomatosis (HP:0000991)6.08639840
7Prolonged partial thromboplastin time (HP:0003645)5.71772196
8Hypolipoproteinemia (HP:0010981)4.80718591
9Hyperlipoproteinemia (HP:0010980)4.77083802
10Complement deficiency (HP:0004431)4.61917090
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.61459636
12Epidermoid cyst (HP:0200040)4.44303276
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.28899175
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.16406335
15Abnormality of the common coagulation pathway (HP:0010990)4.15086278
16Hyperammonemia (HP:0001987)4.14839132
17Hypoalphalipoproteinemia (HP:0003233)4.14018027
18Fat malabsorption (HP:0002630)4.12696590
19Colon cancer (HP:0003003)4.10930573
20Joint hemorrhage (HP:0005261)4.07016327
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.93183254
22Hyperglycinuria (HP:0003108)3.75986933
23Abnormality of methionine metabolism (HP:0010901)3.74057533
24Abnormality of pyrimidine metabolism (HP:0004353)3.69519431
25Abnormality of complement system (HP:0005339)3.61932484
26Hyperglycinemia (HP:0002154)3.61054251
27Hypercholesterolemia (HP:0003124)3.59282176
28Abnormality of glycine metabolism (HP:0010895)3.55200537
29Abnormality of serine family amino acid metabolism (HP:0010894)3.55200537
30Ketosis (HP:0001946)3.53660120
31Conjugated hyperbilirubinemia (HP:0002908)3.49468973
32Selective tooth agenesis (HP:0001592)3.49402899
33Abnormality of the labia minora (HP:0012880)3.46297419
34Hypoglycemic coma (HP:0001325)3.45600375
35Choanal stenosis (HP:0000452)3.35036731
36Abnormality of the intrinsic pathway (HP:0010989)3.32730533
37Hepatoblastoma (HP:0002884)3.32090509
38Ependymoma (HP:0002888)3.29836258
39Septo-optic dysplasia (HP:0100842)3.29071678
40Nephroblastoma (Wilms tumor) (HP:0002667)3.22652392
41Bilateral microphthalmos (HP:0007633)3.20435438
42Malnutrition (HP:0004395)3.14654490
43Right ventricular cardiomyopathy (HP:0011663)3.09888501
44Abnormality of nucleobase metabolism (HP:0010932)3.05151719
45Myocardial infarction (HP:0001658)2.99106326
46Embryonal renal neoplasm (HP:0011794)2.98075041
47Chronic bronchitis (HP:0004469)2.97576507
48Hyperbilirubinemia (HP:0002904)2.94904086
49Vascular calcification (HP:0004934)2.93746439
50Absent eyelashes (HP:0000561)2.92516314
51Steatorrhea (HP:0002570)2.91674935
52Hepatocellular carcinoma (HP:0001402)2.85335319
53Abnormality of fatty-acid metabolism (HP:0004359)2.82162320
54Abnormality of purine metabolism (HP:0004352)2.72967863
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.72111389
56Delayed CNS myelination (HP:0002188)2.71963323
57Esophageal varix (HP:0002040)2.68663112
58Acanthocytosis (HP:0001927)2.66777024
59Cardiovascular calcification (HP:0011915)2.65955034
60Pancreatic islet-cell hyperplasia (HP:0004510)2.62796766
61Spastic diplegia (HP:0001264)2.61093939
62Abnormality of the salivary glands (HP:0010286)2.59119625
63Abnormality of the lacrimal duct (HP:0011481)2.55820902
64Neoplasm of the adrenal cortex (HP:0100641)2.55751982
65Abnormal lung lobation (HP:0002101)2.54387748
66Spontaneous abortion (HP:0005268)2.53827302
67Hyperinsulinemic hypoglycemia (HP:0000825)2.51657663
68Systemic lupus erythematosus (HP:0002725)2.50380914
69Birth length less than 3rd percentile (HP:0003561)2.50271734
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48638296
71Absent eyebrow (HP:0002223)2.47635389
72Homocystinuria (HP:0002156)2.44763143
73Abnormality of homocysteine metabolism (HP:0010919)2.44763143
74Hydroxyprolinuria (HP:0003080)2.44423284
75Abnormality of proline metabolism (HP:0010907)2.44423284
76Ketoacidosis (HP:0001993)2.43734082
77Skin nodule (HP:0200036)2.43376990
78Abnormality of serum amino acid levels (HP:0003112)2.43098742
79Malignant gastrointestinal tract tumors (HP:0006749)2.42208641
80Gastrointestinal carcinoma (HP:0002672)2.42208641
81Multiple enchondromatosis (HP:0005701)2.41148384
82Metabolic acidosis (HP:0001942)2.40941044
83Gout (HP:0001997)2.40322658
84Chromsome breakage (HP:0040012)2.39795105
85Bronchomalacia (HP:0002780)2.35125182
86Breast carcinoma (HP:0003002)2.31684378
87Myelomeningocele (HP:0002475)2.30461707
88Absent hair (HP:0002298)2.29405854
89Clitoromegaly (HP:0000057)2.27555815
90Alopecia of scalp (HP:0002293)2.25623071
91Hypochromic microcytic anemia (HP:0004840)2.25332856
92Biliary tract neoplasm (HP:0100574)2.24884644
93Hemorrhage of the eye (HP:0011885)2.24043423
94Facial cleft (HP:0002006)2.23482215
95Abnormal gallbladder morphology (HP:0012437)2.22669362
96Neonatal onset (HP:0003623)2.22440746
97Cholelithiasis (HP:0001081)2.21596380
98Uterine neoplasm (HP:0010784)2.20707509
99Meckel diverticulum (HP:0002245)2.20320475
100Oral leukoplakia (HP:0002745)2.19230331
101Woolly hair (HP:0002224)2.18056605
102Bifid tongue (HP:0010297)2.17646115
103Stenosis of the external auditory canal (HP:0000402)2.16591344
104Fragile nails (HP:0001808)2.14697908
105Amyloidosis (HP:0011034)2.13804820
106Pendular nystagmus (HP:0012043)2.13398706
107Aplasia/Hypoplasia of the sternum (HP:0006714)2.11870593
108Skull defect (HP:0001362)2.11316499
109Maternal diabetes (HP:0009800)2.11247913
110Glomerulonephritis (HP:0000099)2.10692460
111Rhabdomyosarcoma (HP:0002859)2.10625125
112Lethargy (HP:0001254)2.10179189
113Hypoplastic female external genitalia (HP:0012815)2.10030104
114Sparse eyelashes (HP:0000653)2.09754116
115Late onset (HP:0003584)2.09378867
116Rickets (HP:0002748)2.08927499
117Abnormality of the ileum (HP:0001549)2.08695032
118Hypoglycemic seizures (HP:0002173)2.08631086
119Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06874511
120Dicarboxylic aciduria (HP:0003215)2.06874511
121Cholecystitis (HP:0001082)2.06628962
122Abnormal gallbladder physiology (HP:0012438)2.06628962
123Abnormality of the preputium (HP:0100587)2.06546192
124Abnormality of the nasolacrimal system (HP:0000614)2.06513576
125Pancreatitis (HP:0001733)2.05858496
126Pterygium (HP:0001059)2.03149715
127Short hallux (HP:0010109)2.02535763
128Increased mean platelet volume (HP:0011877)2.02505811
129Abnormality of endocrine pancreas physiology (HP:0012093)2.01131599
130Abnormality of the pancreatic islet cells (HP:0006476)2.01131599
131Abnormal cartilage morphology (HP:0002763)2.01081225
132Labial hypoplasia (HP:0000066)2.00945016
133Plantar hyperkeratosis (HP:0007556)1.99949956
134Impulsivity (HP:0100710)1.99170997
135Carpal bone hypoplasia (HP:0001498)1.99028082
136Mitral stenosis (HP:0001718)1.98611732
137Abnormality of transition element cation homeostasis (HP:0011030)1.98406482
138Esophageal atresia (HP:0002032)1.98271049
139Symptomatic seizures (HP:0011145)1.97438279
140Irritability (HP:0000737)1.96522206
141Breast aplasia (HP:0100783)1.95361761
142Absent radius (HP:0003974)1.94794878
143Abnormality of the clitoris (HP:0000056)1.94178694
144Abnormality of iron homeostasis (HP:0011031)1.92399846
145Scrotal hypoplasia (HP:0000046)1.92371099
146Poikilocytosis (HP:0004447)1.92222078
147Gingival bleeding (HP:0000225)1.91950333
148Vaginal fistula (HP:0004320)1.91692698
149Recurrent gram-negative bacterial infections (HP:0005420)1.90299355
150Ileus (HP:0002595)1.89728514
151Embryonal neoplasm (HP:0002898)1.89529650
152Menorrhagia (HP:0000132)1.89147129
153Cellular immunodeficiency (HP:0005374)1.87985591
154Abnormality of the septum pellucidum (HP:0007375)1.87911617
155Neoplasm of the colon (HP:0100273)1.87787347
156Nephritis (HP:0000123)1.87078790
157Abnormal hair laboratory examination (HP:0003328)1.86934134
158Pili torti (HP:0003777)1.86022739
159Reticulocytosis (HP:0001923)1.84863507
160Aplasia/Hypoplasia of the hallux (HP:0008362)1.84004709
161Hypophosphatemic rickets (HP:0004912)1.83831069
162Proximal tubulopathy (HP:0000114)1.83113083
163Abnormality of chromosome stability (HP:0003220)1.82941648
164Palmoplantar hyperkeratosis (HP:0000972)1.82671240
165Aplasia/Hypoplasia of the breasts (HP:0010311)1.81942962
166Onycholysis (HP:0001806)1.81625630
167Cleft eyelid (HP:0000625)1.81461932
168Back pain (HP:0003418)1.81385453
169Generalized aminoaciduria (HP:0002909)1.81196890
170Absent forearm bone (HP:0003953)1.80440177
171Aplasia involving forearm bones (HP:0009822)1.80440177
172Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80286572
173Abnormality of the gallbladder (HP:0005264)1.78996756
174Absent septum pellucidum (HP:0001331)1.77857786
175Thrombophlebitis (HP:0004418)1.77560842
176Cutaneous syndactyly (HP:0012725)1.77332907
177Partial duplication of thumb phalanx (HP:0009944)1.76806112
178Humeroradial synostosis (HP:0003041)1.76765187
179Synostosis involving the elbow (HP:0003938)1.76765187
180Hypotrichosis (HP:0001006)1.76635379
181Hypoplasia of the pons (HP:0012110)1.76613509
182Palmar hyperkeratosis (HP:0010765)1.76093345
183Coronal craniosynostosis (HP:0004440)1.76025923
184Glioma (HP:0009733)1.71657009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.49604336
2BCKDK4.46977182
3EPHA23.67810409
4SIK13.53847780
5FGFR43.49877847
6CDC73.43392908
7TAF13.21769790
8MST1R3.10834589
9VRK23.09388704
10LATS13.05330530
11SMG12.99096951
12ZAK2.95056326
13TSSK62.72405978
14TNIK2.61507995
15BUB12.41108578
16ERBB42.38294301
17SRPK12.32246804
18PKN22.28183207
19MAP3K32.27926587
20FRK2.21780928
21PTK62.13896213
22MKNK22.02993628
23TRIB31.96991499
24PLK31.95492537
25CDK191.86895244
26MKNK11.80304435
27MAP3K91.61750482
28MET1.61687433
29MAP3K101.60217610
30NME11.59278355
31TYK21.57711846
32RIPK11.53255876
33FLT31.52821466
34TAOK31.51958493
35OXSR11.48894824
36PIK3CG1.48177220
37MAP2K31.46965122
38MAP3K111.43437825
39INSRR1.43204565
40CDK61.41426083
41VRK11.41094790
42STK38L1.37470354
43FER1.35568248
44PASK1.35342287
45LATS21.34351846
46EPHB21.32517976
47STK241.31050256
48DYRK21.30824383
49PTK21.28428735
50EPHB11.27401778
51MAP2K21.27125222
52ERBB21.26929590
53PLK11.26721874
54PBK1.25496624
55PLK41.24405960
56CAMK1G1.23600111
57FGFR21.22998021
58MAPK111.19897002
59NEK91.17233794
60MAP3K21.10187113
61WNK31.09691137
62RPS6KB21.05060682
63GRK61.04506594
64DYRK31.03331856
65ABL21.00976980
66BRSK20.99777407
67CHEK20.99494832
68KDR0.98702010
69NEK20.98200631
70EPHA30.96245567
71MAP2K40.93979094
72MAP3K70.90589858
73BMX0.89936909
74STK100.89678564
75ATR0.89173653
76FGFR10.89153737
77ALK0.88431853
78TTN0.88138618
79DYRK1B0.87178235
80MAPKAPK30.87013067
81CSNK1G10.85718310
82EIF2AK20.85348673
83CDK70.84101612
84JAK20.80997593
85TRIM280.79357781
86BRD40.79121127
87STK40.77245394
88TBK10.75288620
89CHEK10.74102627
90MAP3K80.73825921
91MTOR0.73537210
92JAK10.73072026
93LRRK20.72791709
94STK30.72321449
95PRKAA20.72059325
96DAPK20.72000737
97ATM0.71752705
98PAK40.70294760
99MAP2K60.70030163
100ACVR1B0.69694437
101TAOK10.69560267
102PRKCI0.67572593
103AURKB0.64542312
104GSK3A0.64195990
105MAPK150.63727953
106STK160.63332395
107MST40.63322697
108PDGFRA0.61420514
109MAP3K140.59369405
110TGFBR20.59092213
111PIM10.59068973
112MAP2K10.59008517
113WEE10.58429742
114RPS6KA40.58017190
115EIF2AK30.57514428
116FGFR30.56294907
117TGFBR10.56253210
118CDK40.53726966
119NUAK10.53256550
120CSNK1E0.52986285
121CSK0.50981329
122EEF2K0.48063585
123DAPK10.47666491
124CDK10.47414822
125CDK20.47391710
126GRK10.47337322
127DMPK0.46931586
128NEK10.46931378
129MAP3K10.46672875
130CDK120.46601467
131PAK20.45472687
132MAPK40.44777450
133TAOK20.43570854
134CAMK1D0.43226709
135STK390.41939144
136PRKDC0.41868080
137PRKG20.41284871
138PRKCZ0.40326497
139DDR20.38676801
140CASK0.38517912
141YES10.37870013
142CHUK0.35373440
143NLK0.34536011
144PRKACG0.33916299
145MAP3K50.33314294
146TYRO30.33046318
147MELK0.32463507
148CSNK2A10.31529580
149NEK60.30993298
150MUSK0.30949180
151CSNK2A20.30898916
152CSNK1D0.30660177
153TLK10.30628976
154CSNK1A10.30332509
155BMPR1B0.29957027
156EGFR0.29291737
157TESK10.29145362
158TIE10.28272391
159IRAK30.25851337
160AKT20.25604143
161IGF1R0.25434598
162RPS6KA10.25148434
163ICK0.25138207
164CAMK2G0.25115666
165TRPM70.23394715
166TTK0.21451197

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.09857863
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.53604476
3Nitrogen metabolism_Homo sapiens_hsa009103.42617804
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18822929
5Arginine biosynthesis_Homo sapiens_hsa002202.95829449
6DNA replication_Homo sapiens_hsa030302.76034645
7Mismatch repair_Homo sapiens_hsa034302.63307432
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59298478
9Tryptophan metabolism_Homo sapiens_hsa003802.59270662
10Complement and coagulation cascades_Homo sapiens_hsa046102.57876043
11Non-homologous end-joining_Homo sapiens_hsa034502.40809463
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39885379
13Fatty acid degradation_Homo sapiens_hsa000712.38977431
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38019661
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34622716
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34280087
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.28277646
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19364545
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13339308
20Histidine metabolism_Homo sapiens_hsa003402.10552870
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06471882
22Chemical carcinogenesis_Homo sapiens_hsa052042.05174020
23Caffeine metabolism_Homo sapiens_hsa002321.98565776
24Base excision repair_Homo sapiens_hsa034101.97909195
25Peroxisome_Homo sapiens_hsa041461.89782218
26RNA transport_Homo sapiens_hsa030131.89420771
27Fat digestion and absorption_Homo sapiens_hsa049751.89358862
28PPAR signaling pathway_Homo sapiens_hsa033201.89209185
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.84533894
30Spliceosome_Homo sapiens_hsa030401.82677995
31Butanoate metabolism_Homo sapiens_hsa006501.82646857
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.78616216
33Retinol metabolism_Homo sapiens_hsa008301.78112675
34Phenylalanine metabolism_Homo sapiens_hsa003601.69983208
35RNA polymerase_Homo sapiens_hsa030201.69845603
36Staphylococcus aureus infection_Homo sapiens_hsa051501.68686616
37beta-Alanine metabolism_Homo sapiens_hsa004101.68597218
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67068742
39Selenocompound metabolism_Homo sapiens_hsa004501.67014343
40Propanoate metabolism_Homo sapiens_hsa006401.64412181
41Homologous recombination_Homo sapiens_hsa034401.63416992
42Fatty acid metabolism_Homo sapiens_hsa012121.61988500
43Bile secretion_Homo sapiens_hsa049761.59486933
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53604913
45Starch and sucrose metabolism_Homo sapiens_hsa005001.49622592
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47468956
47Tyrosine metabolism_Homo sapiens_hsa003501.42566122
48Sulfur metabolism_Homo sapiens_hsa009201.42474213
49Proteasome_Homo sapiens_hsa030501.41598709
50mRNA surveillance pathway_Homo sapiens_hsa030151.35387979
51Basal transcription factors_Homo sapiens_hsa030221.34517289
52Folate biosynthesis_Homo sapiens_hsa007901.33455784
53Cell cycle_Homo sapiens_hsa041101.32659530
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.31380005
55Vitamin digestion and absorption_Homo sapiens_hsa049771.31269526
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.27599471
57Pyruvate metabolism_Homo sapiens_hsa006201.27575846
58ABC transporters_Homo sapiens_hsa020101.25890700
59Biosynthesis of amino acids_Homo sapiens_hsa012301.22023039
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19830366
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16827995
62Steroid biosynthesis_Homo sapiens_hsa001001.15722367
63Fatty acid elongation_Homo sapiens_hsa000621.13809720
64Carbon metabolism_Homo sapiens_hsa012001.09893047
65RNA degradation_Homo sapiens_hsa030181.04467482
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.01276501
67Fanconi anemia pathway_Homo sapiens_hsa034601.01067031
68Arginine and proline metabolism_Homo sapiens_hsa003300.99738696
69Nucleotide excision repair_Homo sapiens_hsa034200.92777680
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91436959
71Glutathione metabolism_Homo sapiens_hsa004800.90577856
72One carbon pool by folate_Homo sapiens_hsa006700.90097627
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89396881
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88557428
75Hippo signaling pathway_Homo sapiens_hsa043900.87289669
76Lysine degradation_Homo sapiens_hsa003100.86963909
77Sulfur relay system_Homo sapiens_hsa041220.86232237
78Wnt signaling pathway_Homo sapiens_hsa043100.83436876
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83419278
80Ribosome_Homo sapiens_hsa030100.82326340
81Pyrimidine metabolism_Homo sapiens_hsa002400.80468771
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78920983
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77849882
84Glycerolipid metabolism_Homo sapiens_hsa005610.72711541
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63856000
86Pentose phosphate pathway_Homo sapiens_hsa000300.62362031
87Ether lipid metabolism_Homo sapiens_hsa005650.58852454
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57127016
89Purine metabolism_Homo sapiens_hsa002300.55102163
90Systemic lupus erythematosus_Homo sapiens_hsa053220.54818203
91p53 signaling pathway_Homo sapiens_hsa041150.54671179
92Vitamin B6 metabolism_Homo sapiens_hsa007500.54035460
93Galactose metabolism_Homo sapiens_hsa000520.52147974
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47364194
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46674385
96Fatty acid biosynthesis_Homo sapiens_hsa000610.45659733
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40442141
98Linoleic acid metabolism_Homo sapiens_hsa005910.38912518
99Fructose and mannose metabolism_Homo sapiens_hsa000510.38534996
100Metabolic pathways_Homo sapiens_hsa011000.37785289
101Insulin resistance_Homo sapiens_hsa049310.32901081
102Renin-angiotensin system_Homo sapiens_hsa046140.32043784
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30959855
104Mineral absorption_Homo sapiens_hsa049780.25158558
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.23014966
106Prion diseases_Homo sapiens_hsa050200.22881943
107Bladder cancer_Homo sapiens_hsa052190.15854652
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.14452603
109Protein digestion and absorption_Homo sapiens_hsa049740.11693140
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04232524
111Glucagon signaling pathway_Homo sapiens_hsa049220.03801016
112AMPK signaling pathway_Homo sapiens_hsa041520.01919544
113Arachidonic acid metabolism_Homo sapiens_hsa005900.01741198
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.01738207
115Hepatitis C_Homo sapiens_hsa051600.00068949
116Adherens junction_Homo sapiens_hsa045200.00010776
117TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1382723
118Tight junction_Homo sapiens_hsa04530-0.1333226
119Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1314782
120Legionellosis_Homo sapiens_hsa05134-0.1203185
121Pertussis_Homo sapiens_hsa05133-0.1107451
122Thyroid cancer_Homo sapiens_hsa05216-0.1103294
123ECM-receptor interaction_Homo sapiens_hsa04512-0.0962586
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0940155
125Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0566777
126Amoebiasis_Homo sapiens_hsa05146-0.0325614
127Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0314595
128Basal cell carcinoma_Homo sapiens_hsa05217-0.0225086
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0131991

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