EPB41L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)5.81698656
2rhodopsin mediated signaling pathway (GO:0016056)5.63875012
3retinal cone cell development (GO:0046549)4.52089490
4photoreceptor cell maintenance (GO:0045494)3.89624088
5photoreceptor cell development (GO:0042461)3.86524806
6eye photoreceptor cell development (GO:0042462)3.67491411
7paraxial mesoderm development (GO:0048339)3.60757233
8retinal rod cell development (GO:0046548)3.59804592
9positive regulation of SMAD protein import into nucleus (GO:0060391)3.57023387
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.52355375
11phototransduction (GO:0007602)3.47632574
12phototransduction, visible light (GO:0007603)3.44520400
13protein heterotrimerization (GO:0070208)3.42867880
14adherens junction assembly (GO:0034333)3.40962429
15apoptotic cell clearance (GO:0043277)3.40604701
16microglial cell activation (GO:0001774)3.36053789
17regulation of SMAD protein import into nucleus (GO:0060390)3.27725211
18cell-substrate adherens junction assembly (GO:0007045)3.26157114
19focal adhesion assembly (GO:0048041)3.26157114
20detection of light stimulus (GO:0009583)3.22695347
21detection of visible light (GO:0009584)3.21172827
22chondrocyte proliferation (GO:0035988)3.20997559
23negative regulation of granulocyte differentiation (GO:0030853)3.18861065
24cell adhesion mediated by integrin (GO:0033627)3.17810593
25detection of light stimulus involved in sensory perception (GO:0050962)3.15520171
26detection of light stimulus involved in visual perception (GO:0050908)3.15520171
27nuclear pore complex assembly (GO:0051292)3.14840726
28collagen fibril organization (GO:0030199)3.14230850
29adaptation of signaling pathway (GO:0023058)2.96653496
30cytoplasmic mRNA processing body assembly (GO:0033962)2.94346774
31visual perception (GO:0007601)2.92513582
32barbed-end actin filament capping (GO:0051016)2.91375042
33* cortical actin cytoskeleton organization (GO:0030866)2.90503455
34basement membrane organization (GO:0071711)2.89496796
35photoreceptor cell differentiation (GO:0046530)2.87424184
36eye photoreceptor cell differentiation (GO:0001754)2.87424184
37cell-substrate junction assembly (GO:0007044)2.87335070
38sensory perception of light stimulus (GO:0050953)2.86782413
39negative regulation of fatty acid transport (GO:2000192)2.85864233
40notochord development (GO:0030903)2.81948785
41NLS-bearing protein import into nucleus (GO:0006607)2.81337989
42retina development in camera-type eye (GO:0060041)2.77540233
43skin morphogenesis (GO:0043589)2.76878173
44ruffle organization (GO:0031529)2.74380991
45regulation of interferon-beta biosynthetic process (GO:0045357)2.74283653
46negative regulation of smooth muscle cell migration (GO:0014912)2.71535868
47endothelial cell morphogenesis (GO:0001886)2.69824979
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.69028874
49stress fiber assembly (GO:0043149)2.68786660
50positive regulation of guanylate cyclase activity (GO:0031284)2.68155149
51regulation of mitotic spindle organization (GO:0060236)2.68066907
52keratan sulfate catabolic process (GO:0042340)2.65302600
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65278385
54positive regulation by organism of defense response of other organism involved in symbiotic interact2.65278385
55modulation by symbiont of host immune response (GO:0052553)2.65278385
56positive regulation by symbiont of host defense response (GO:0052509)2.65278385
57modulation by symbiont of host defense response (GO:0052031)2.65278385
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65278385
59regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.64415074
60protein retention in ER lumen (GO:0006621)2.64041529
61substrate adhesion-dependent cell spreading (GO:0034446)2.63494964
62macrophage activation involved in immune response (GO:0002281)2.63274048
63endodermal cell differentiation (GO:0035987)2.62536359
64planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61651083
65cellular response to light stimulus (GO:0071482)2.60873929
66retina vasculature morphogenesis in camera-type eye (GO:0061299)2.60869324
67regulation of apoptotic cell clearance (GO:2000425)2.60743793
68negative regulation of chondrocyte differentiation (GO:0032331)2.60547403
69germ cell migration (GO:0008354)2.60437748
70hippo signaling (GO:0035329)2.60232948
71mitotic chromosome condensation (GO:0007076)2.58849656
72regulation of chemokine-mediated signaling pathway (GO:0070099)2.57553000
73negative regulation of Rho protein signal transduction (GO:0035024)2.56234449
74regulation of early endosome to late endosome transport (GO:2000641)2.54375550
75nuclear pore organization (GO:0006999)2.53355478
76regulation of macrophage chemotaxis (GO:0010758)2.51817214
77positive regulation of osteoblast proliferation (GO:0033690)2.51326679
78vascular endothelial growth factor signaling pathway (GO:0038084)2.51089135
79adhesion of symbiont to host (GO:0044406)2.50633176
80mannose metabolic process (GO:0006013)2.49569374
81peripheral nervous system axon ensheathment (GO:0032292)2.49310902
82myelination in peripheral nervous system (GO:0022011)2.49310902
83regulation of nucleobase-containing compound transport (GO:0032239)2.47035855
84insulin-like growth factor receptor signaling pathway (GO:0048009)2.44183875
85sodium ion export (GO:0071436)2.44032926
86peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.43144973
87amino acid import (GO:0043090)2.42804064
88positive regulation of endothelial cell apoptotic process (GO:2000353)2.42119898
89* cortical cytoskeleton organization (GO:0030865)2.41621127
90synaptic vesicle docking involved in exocytosis (GO:0016081)2.41587939
91COPI coating of Golgi vesicle (GO:0048205)2.41198082
92Golgi transport vesicle coating (GO:0048200)2.41198082
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.39887001
94phagocytosis, engulfment (GO:0006911)2.39647683
95fibroblast migration (GO:0010761)2.39351365
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.38851866
97response to fluid shear stress (GO:0034405)2.38410488
98epithelial cell-cell adhesion (GO:0090136)2.38052627
99DNA unwinding involved in DNA replication (GO:0006268)2.37909943
100regulation of glucose import in response to insulin stimulus (GO:2001273)2.37885507
101glomerular filtration (GO:0003094)2.37882139
102response to lipoprotein particle (GO:0055094)2.37840602
103axon extension involved in axon guidance (GO:0048846)2.37141850
104neuron projection extension involved in neuron projection guidance (GO:1902284)2.37141850
105mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.37109032
106platelet-derived growth factor receptor signaling pathway (GO:0048008)2.36367966
107collagen metabolic process (GO:0032963)2.36036831
108activated T cell proliferation (GO:0050798)2.35296726
109regulation of transforming growth factor beta2 production (GO:0032909)2.35241324
110protein localization to endosome (GO:0036010)2.35163097
111renal filtration (GO:0097205)2.34465590
112regulation of clathrin-mediated endocytosis (GO:2000369)2.33712609
113protein localization to cell surface (GO:0034394)2.33089047
114response to laminar fluid shear stress (GO:0034616)2.32908006
115kidney mesenchyme development (GO:0072074)2.32837910
116negative regulation of catenin import into nucleus (GO:0035414)2.32360145
117cell volume homeostasis (GO:0006884)2.32074296
118positive regulation of macrophage cytokine production (GO:0060907)2.31795791
119monocyte differentiation (GO:0030224)2.31739852
120multicellular organismal macromolecule metabolic process (GO:0044259)2.31565847
121blood vessel endothelial cell migration (GO:0043534)2.31475092
122detection of external stimulus (GO:0009581)2.30860290
123positive regulation of extracellular matrix organization (GO:1903055)2.30152203
124mitotic cytokinesis (GO:0000281)2.29857534
125collagen catabolic process (GO:0030574)2.29759865
126negative regulation of vascular permeability (GO:0043116)2.29176603
127cellular hyperosmotic response (GO:0071474)2.28637339
128regulation of RNA export from nucleus (GO:0046831)2.28569532
129white fat cell differentiation (GO:0050872)2.26522824
130semaphorin-plexin signaling pathway (GO:0071526)2.26491479
131regulation of guanylate cyclase activity (GO:0031282)2.25853378
132cell migration involved in heart development (GO:0060973)2.25791186
133substrate-dependent cell migration (GO:0006929)2.24771920
134convergent extension (GO:0060026)2.24033148
135negative regulation of cartilage development (GO:0061037)2.22914421
136outer ear morphogenesis (GO:0042473)2.22714198
137cell communication by electrical coupling (GO:0010644)2.22106881
138detection of abiotic stimulus (GO:0009582)2.21449290
139regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21409952
140cell migration involved in sprouting angiogenesis (GO:0002042)2.20882912
141glomerular visceral epithelial cell development (GO:0072015)2.20180671
142low-density lipoprotein particle clearance (GO:0034383)2.19867005
143L-amino acid import (GO:0043092)2.19177554
144positive regulation of glucose transport (GO:0010828)2.19004894
145pathway-restricted SMAD protein phosphorylation (GO:0060389)2.18697420
146glial cell migration (GO:0008347)2.17837175
147regulation of extracellular matrix disassembly (GO:0010715)2.15857596
148metanephric mesenchyme development (GO:0072075)2.14996458
149extracellular matrix assembly (GO:0085029)2.14629336
150multicellular organismal metabolic process (GO:0044236)2.14601132
151cochlea morphogenesis (GO:0090103)2.12311502
152glomerular basement membrane development (GO:0032836)2.12180163
153regulation of catenin import into nucleus (GO:0035412)2.11965675
154cell proliferation involved in metanephros development (GO:0072203)2.11586904
155cellular response to interferon-alpha (GO:0035457)2.10965186
156cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.10758487
157cytoskeleton-dependent cytokinesis (GO:0061640)2.10708829
158regulation of protein polyubiquitination (GO:1902914)2.09933802
159positive regulation of glucose import (GO:0046326)2.09404372
160embryonic retina morphogenesis in camera-type eye (GO:0060059)2.08863109
161cell morphogenesis involved in neuron differentiation (GO:0048667)2.08790525
162pore complex assembly (GO:0046931)2.08538969
163protein targeting to plasma membrane (GO:0072661)2.08424265
164positive regulation of catenin import into nucleus (GO:0035413)2.08322232
165mitotic sister chromatid cohesion (GO:0007064)2.07812841
166cardiac myofibril assembly (GO:0055003)2.07801156
167embryonic camera-type eye morphogenesis (GO:0048596)2.07346546
168cellular protein complex localization (GO:0034629)2.07094443
169anterior/posterior axis specification, embryo (GO:0008595)2.06890991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74775109
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.68903555
3E2F7_22180533_ChIP-Seq_HELA_Human3.08019406
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.85076130
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.75999975
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.62253075
7AR_21909140_ChIP-Seq_LNCAP_Human2.58727243
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33622471
9* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.19438481
10CLOCK_20551151_ChIP-Seq_293T_Human2.19021863
11* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.12017220
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.08942930
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03071813
14* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97804552
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92113075
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89178165
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88993474
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.88883570
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82198372
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79766330
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74812753
22KDM2B_26808549_Chip-Seq_DND41_Human1.74500009
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.74137284
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73251253
25TP53_16413492_ChIP-PET_HCT116_Human1.70428355
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69716214
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69563650
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68825844
29CJUN_26792858_Chip-Seq_BT549_Human1.65223256
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.62751436
31DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.62286502
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60898162
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57525473
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.56616059
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55613185
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.55076729
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54636879
38* FOXA2_19822575_ChIP-Seq_HepG2_Human1.53961420
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53432352
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.52559131
41KDM2B_26808549_Chip-Seq_K562_Human1.50216432
42BRD4_25478319_ChIP-Seq_HGPS_Human1.50174478
43* EP300_21415370_ChIP-Seq_HL-1_Mouse1.49618273
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49491497
45RUNX_20019798_ChIP-Seq_JUKART_Human1.48825952
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48655811
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.48209073
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46672776
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46423853
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45957930
51VDR_24787735_ChIP-Seq_THP-1_Human1.45230989
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44731954
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44114501
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.44044062
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.43833160
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43783032
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42699717
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42699717
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.42514533
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.41802435
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41326229
62TCF7_22412390_ChIP-Seq_EML_Mouse1.40700492
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.40628160
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.39885542
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39652454
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39396685
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39396685
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39396685
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36715702
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.35056677
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34649464
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34477418
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34451329
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34264389
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33170212
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33144540
77FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.32330543
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32305275
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32250758
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31906088
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30722626
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30458808
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30400255
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.28308224
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.28308224
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.27540856
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25062640
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24546805
89DROSHA_22980978_ChIP-Seq_HELA_Human1.23940595
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23478615
91TCF4_18268006_ChIP-ChIP_LS174T_Human1.23010195
92SPI1_23127762_ChIP-Seq_K562_Human1.22281170
93* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19562967
94* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.19199610
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19185224
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18460502
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16095790
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15878797
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15701543
100TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14889238
101EED_16625203_ChIP-ChIP_MESCs_Mouse1.13667959
102AHR_22903824_ChIP-Seq_MCF-7_Human1.13270362
103* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12798483
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12359190
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.11744474
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.08865455
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07830070
108ZNF263_19887448_ChIP-Seq_K562_Human1.07280138
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06531416
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05742660
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.04787462
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04317903
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.03612592
114VDR_21846776_ChIP-Seq_THP-1_Human1.03493856
115* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01796940
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01649968
117LXR_22292898_ChIP-Seq_THP-1_Human1.01526941
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01210782
119SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00861354
120RUNX1_27514584_Chip-Seq_MCF-7_Human1.00547195
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99611512
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.98766687
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98035296
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97484758
125LXR_22158963_ChIP-Seq_LIVER_Mouse0.96618967
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96499408
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96442103
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96160737
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.95828296
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95478171
131MYC_22102868_ChIP-Seq_BL_Human0.94676258
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94607965
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.93915972
134TP53_22127205_ChIP-Seq_IMR90_Human0.93533618
135TP53_23651856_ChIP-Seq_MEFs_Mouse0.92909181
136VDR_24763502_ChIP-Seq_THP-1_Human0.92800430
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92400085
138RACK7_27058665_Chip-Seq_MCF-7_Human0.92357857
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92237336
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90788302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.90308549
2MP0003011_delayed_dark_adaptation4.05419103
3MP0005551_abnormal_eye_electrophysiolog3.83248875
4MP0003705_abnormal_hypodermis_morpholog3.06446829
5MP0003950_abnormal_plasma_membrane2.77524546
6MP0005253_abnormal_eye_physiology2.65075737
7MP0004272_abnormal_basement_membrane2.51852835
8MP0005275_abnormal_skin_tensile2.51292664
9MP0005623_abnormal_meninges_morphology2.51033525
10MP0004185_abnormal_adipocyte_glucose2.44511293
11MP0003045_fibrosis2.42820894
12MP0005257_abnormal_intraocular_pressure2.33134806
13MP0003279_aneurysm2.25861071
14MP0006072_abnormal_retinal_apoptosis2.19170388
15MP0005503_abnormal_tendon_morphology2.16601962
16MP0000751_myopathy2.07080523
17MP0005076_abnormal_cell_differentiation2.06644574
18MP0005666_abnormal_adipose_tissue2.02234366
19MP0002877_abnormal_melanocyte_morpholog2.01361465
20MP0002090_abnormal_vision1.99307724
21MP0005195_abnormal_posterior_eye1.99089516
22MP0005670_abnormal_white_adipose1.99070140
23MP0000733_abnormal_muscle_development1.91477679
24MP0003566_abnormal_cell_adhesion1.89247175
25MP0001324_abnormal_eye_pigmentation1.75903795
26MP0009780_abnormal_chondrocyte_physiolo1.74365877
27MP0003172_abnormal_lysosome_physiology1.73566610
28MP0005391_vision/eye_phenotype1.73078186
29MP0001958_emphysema1.68395642
30MP0009384_cardiac_valve_regurgitation1.66984548
31MP0003091_abnormal_cell_migration1.64042127
32MP0000569_abnormal_digit_pigmentation1.62663494
33MP0005375_adipose_tissue_phenotype1.61749203
34MP0010352_gastrointestinal_tract_polyps1.59397939
35MP0002653_abnormal_ependyma_morphology1.56385242
36MP0005409_darkened_coat_color1.55797232
37MP0003941_abnormal_skin_development1.46932554
38MP0001915_intracranial_hemorrhage1.44746772
39MP0005023_abnormal_wound_healing1.44204822
40MP0003690_abnormal_glial_cell1.40277386
41MP0000767_abnormal_smooth_muscle1.37877899
42MP0003303_peritoneal_inflammation1.33788968
43MP0006138_congestive_heart_failure1.28116246
44MP0002168_other_aberrant_phenotype1.26915621
45MP0000003_abnormal_adipose_tissue1.25953739
46MP0002108_abnormal_muscle_morphology1.23564717
47MP0005197_abnormal_uvea_morphology1.22304095
48MP0003300_gastrointestinal_ulcer1.21732755
49MP0004233_abnormal_muscle_weight1.21664966
50MP0009278_abnormal_bone_marrow1.21637573
51MP0000762_abnormal_tongue_morphology1.21370769
52MP0004134_abnormal_chest_morphology1.19281135
53MP0003191_abnormal_cellular_cholesterol1.17344585
54MP0002089_abnormal_postnatal_growth/wei1.14870210
55MP0001730_embryonic_growth_arrest1.14352897
56MP0003385_abnormal_body_wall1.13610982
57MP0002697_abnormal_eye_size1.12363536
58MP0003329_amyloid_beta_deposits1.12062038
59MP0009250_abnormal_appendicular_skeleto1.10371367
60MP0001299_abnormal_eye_distance/1.08629512
61MP0005508_abnormal_skeleton_morphology1.08136358
62MP0001879_abnormal_lymphatic_vessel1.07907631
63MP0004858_abnormal_nervous_system1.07393722
64MP0003634_abnormal_glial_cell1.06957507
65MP0009672_abnormal_birth_weight1.05065179
66MP0000759_abnormal_skeletal_muscle1.04834458
67MP0005058_abnormal_lysosome_morphology1.04721536
68MP0004130_abnormal_muscle_cell1.04112731
69MP0002998_abnormal_bone_remodeling1.03619838
70MP0003942_abnormal_urinary_system1.03040386
71MP0000747_muscle_weakness1.02715355
72MP0006082_CNS_inflammation1.02437830
73MP0002295_abnormal_pulmonary_circulatio0.99928958
74MP0001614_abnormal_blood_vessel0.99357885
75MP0002925_abnormal_cardiovascular_devel0.99221555
76MP0003868_abnormal_feces_composition0.98058434
77MP0000462_abnormal_digestive_system0.95208995
78MP0002269_muscular_atrophy0.92844584
79MP0000920_abnormal_myelination0.90792623
80MP0002971_abnormal_brown_adipose0.90555772
81MP0010368_abnormal_lymphatic_system0.89332676
82MP0003111_abnormal_nucleus_morphology0.88465280
83MP0000013_abnormal_adipose_tissue0.88230893
84MP0002092_abnormal_eye_morphology0.87498021
85MP0009053_abnormal_anal_canal0.87050894
86MP0000534_abnormal_ureter_morphology0.86388249
87MP0005595_abnormal_vascular_smooth0.85856729
88MP0004859_abnormal_synaptic_plasticity0.84975242
89MP0003283_abnormal_digestive_organ0.84935324
90MP0000750_abnormal_muscle_regeneration0.84187926
91MP0002114_abnormal_axial_skeleton0.84118213
92MP0001851_eye_inflammation0.83796617
93MP0002896_abnormal_bone_mineralization0.83450488
94MP0005380_embryogenesis_phenotype0.81916539
95MP0001672_abnormal_embryogenesis/_devel0.81916539
96MP0001533_abnormal_skeleton_physiology0.81703715
97MP0000428_abnormal_craniofacial_morphol0.81573117
98MP0002085_abnormal_embryonic_tissue0.81054782
99MP0010307_abnormal_tumor_latency0.80544012
100MP0003828_pulmonary_edema0.80251497
101MP0004270_analgesia0.80155487
102MP0002084_abnormal_developmental_patter0.80061013
103MP0002086_abnormal_extraembryonic_tissu0.79836572
104MP0003984_embryonic_growth_retardation0.78948720
105MP0003448_altered_tumor_morphology0.78353642
106MP0000350_abnormal_cell_proliferation0.78352150
107MP0003115_abnormal_respiratory_system0.77089253
108MP0005193_abnormal_anterior_eye0.77063107
109MP0005621_abnormal_cell_physiology0.76791783
110MP0002229_neurodegeneration0.75731303
111MP0010030_abnormal_orbit_morphology0.75675928
112MP0002128_abnormal_blood_circulation0.75428668
113MP0002282_abnormal_trachea_morphology0.74798317
114MP0003937_abnormal_limbs/digits/tail_de0.74362455
115MP0000163_abnormal_cartilage_morphology0.74201121
116MP0000749_muscle_degeneration0.74131712
117MP0005167_abnormal_blood-brain_barrier0.73864002
118MP0010630_abnormal_cardiac_muscle0.73266055
119MP0002088_abnormal_embryonic_growth/wei0.73232716
120MP0005390_skeleton_phenotype0.72668218
121MP0001177_atelectasis0.72255909
122MP0004087_abnormal_muscle_fiber0.72231238
123MP0002396_abnormal_hematopoietic_system0.69981772
124MP0006054_spinal_hemorrhage0.69862485
125MP0008932_abnormal_embryonic_tissue0.69801439
126MP0004036_abnormal_muscle_relaxation0.69790114
127MP0001348_abnormal_lacrimal_gland0.69074112
128MP0009115_abnormal_fat_cell0.68858195
129MP0002116_abnormal_craniofacial_bone0.68704213
130MP0002060_abnormal_skin_morphology0.68215491
131MP0000343_altered_response_to0.68023155
132MP0001661_extended_life_span0.67645856
133MP0004084_abnormal_cardiac_muscle0.67372274
134MP0002115_abnormal_skeleton_extremities0.65986391
135MP0000432_abnormal_head_morphology0.65833712
136MP0001849_ear_inflammation0.64276916
137MP0004197_abnormal_fetal_growth/weight/0.62433569
138MP0005171_absent_coat_pigmentation0.60422908
139MP0002166_altered_tumor_susceptibility0.59081946
140MP0003935_abnormal_craniofacial_develop0.58470209
141MP0000266_abnormal_heart_morphology0.57556735
142MP0002933_joint_inflammation0.57274266
143MP0004808_abnormal_hematopoietic_stem0.57251524

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.04281526
2Bony spicule pigmentary retinopathy (HP:0007737)5.60602677
3Pigmentary retinal degeneration (HP:0001146)5.13922402
4Chorioretinal atrophy (HP:0000533)5.05875246
5Abnormal rod and cone electroretinograms (HP:0008323)4.42254110
6Cerebral aneurysm (HP:0004944)4.38937641
7Absent rod-and cone-mediated responses on ERG (HP:0007688)4.33961677
8Pendular nystagmus (HP:0012043)4.11952964
9Abolished electroretinogram (ERG) (HP:0000550)3.86716990
10Protrusio acetabuli (HP:0003179)3.86290264
11Scotoma (HP:0000575)3.84518774
12Aortic aneurysm (HP:0004942)3.82205637
13Central scotoma (HP:0000603)3.74958299
14Dyschromatopsia (HP:0007641)3.71010571
15Premature rupture of membranes (HP:0001788)3.66371416
16Aortic dissection (HP:0002647)3.51515534
17Arterial tortuosity (HP:0005116)3.33380835
18Vascular tortuosity (HP:0004948)3.27131486
19Vitreoretinal degeneration (HP:0000655)3.23684373
20Abnormality of macular pigmentation (HP:0008002)3.08106210
21Increased corneal curvature (HP:0100692)3.02458043
22Keratoconus (HP:0000563)3.02458043
23Attenuation of retinal blood vessels (HP:0007843)2.92894936
24Subcapsular cataract (HP:0000523)2.89946874
25Shallow orbits (HP:0000586)2.88683347
26Mitral valve prolapse (HP:0001634)2.88362009
27Retinal atrophy (HP:0001105)2.85766761
28Ankle contracture (HP:0006466)2.82674214
29Macular degeneration (HP:0000608)2.79157319
30Posterior subcapsular cataract (HP:0007787)2.77437273
31Urethral obstruction (HP:0000796)2.75032047
32Neonatal short-limb short stature (HP:0008921)2.70954606
33Bladder diverticulum (HP:0000015)2.69115745
34Type II diabetes mellitus (HP:0005978)2.63841408
35Soft skin (HP:0000977)2.63571012
36Choroideremia (HP:0001139)2.63461223
37Hematochezia (HP:0002573)2.55941014
38Cone-rod dystrophy (HP:0000548)2.54092947
39Complement deficiency (HP:0004431)2.53332049
40Dilatation of the ascending aorta (HP:0005111)2.49901861
41Abnormality of complement system (HP:0005339)2.44836796
42Atrophic scars (HP:0001075)2.43677311
43Striae distensae (HP:0001065)2.40735731
44Segmental peripheral demyelination/remyelination (HP:0003481)2.39825552
45Photophobia (HP:0000613)2.39552629
46Type 1 muscle fiber predominance (HP:0003803)2.34566331
47Genu recurvatum (HP:0002816)2.29844756
48Vertebral compression fractures (HP:0002953)2.26643874
49Decreased central vision (HP:0007663)2.25535616
50Overgrowth (HP:0001548)2.23225716
51Disproportionate tall stature (HP:0001519)2.21062827
52Renal duplication (HP:0000075)2.19455909
53Ulnar claw (HP:0001178)2.18954993
54Coronal craniosynostosis (HP:0004440)2.18658040
55Insomnia (HP:0100785)2.16471625
56Increased variability in muscle fiber diameter (HP:0003557)2.14320833
57Turricephaly (HP:0000262)2.13911853
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.12096861
59Osteolytic defects of the hand bones (HP:0009699)2.12096861
60Progressive visual loss (HP:0000529)2.11694538
61Renovascular hypertension (HP:0100817)2.08300399
62Spondylolisthesis (HP:0003302)2.05817955
63Broad metatarsal (HP:0001783)2.05391755
64Systemic lupus erythematosus (HP:0002725)2.03964047
65Round ear (HP:0100830)2.03071986
66Aneurysm (HP:0002617)2.02121510
67Constricted visual fields (HP:0001133)1.99552753
68Wide anterior fontanel (HP:0000260)1.98434947
69Vertebral arch anomaly (HP:0008438)1.98387444
70Blue sclerae (HP:0000592)1.97315741
71Asymmetry of the thorax (HP:0001555)1.95991005
72Mitral regurgitation (HP:0001653)1.95930714
73Camptodactyly of toe (HP:0001836)1.95701822
74Syringomyelia (HP:0003396)1.95008994
75Spinal cord lesions (HP:0100561)1.95008994
76Scapular winging (HP:0003691)1.94375205
77Abnormality of the acetabulum (HP:0003170)1.92813087
78Peritonitis (HP:0002586)1.91514699
79Aplasia involving bones of the upper limbs (HP:0009823)1.91082716
80Aplasia of the phalanges of the hand (HP:0009802)1.91082716
81Aplasia involving bones of the extremities (HP:0009825)1.91082716
82Termporal pattern (HP:0011008)1.88746742
83Insidious onset (HP:0003587)1.88746742
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.87319308
85Abnormality of skeletal muscle fiber size (HP:0012084)1.87225670
86Bronchomalacia (HP:0002780)1.86968436
87Joint laxity (HP:0001388)1.85475186
88Macroorchidism (HP:0000053)1.82897799
89Abnormal ossification of hand bones (HP:0005921)1.82865585
90Arnold-Chiari malformation (HP:0002308)1.82584707
91Biconcave vertebral bodies (HP:0004586)1.81371804
92Mild short stature (HP:0003502)1.79473966
93Deep venous thrombosis (HP:0002625)1.78577234
94Bowel diverticulosis (HP:0005222)1.78548289
95Increased cerebral lipofuscin (HP:0011813)1.78491984
96Abnormality of the calcaneus (HP:0008364)1.78355171
97Abnormal delivery (HP:0001787)1.77813980
98Abnormality of carpal bone ossification (HP:0006257)1.77178851
99Obstructive sleep apnea (HP:0002870)1.75589506
100Flat cornea (HP:0007720)1.74923810
101Thin ribs (HP:0000883)1.74856600
102Mitral stenosis (HP:0001718)1.74478241
103Wormian bones (HP:0002645)1.74232219
104Overriding aorta (HP:0002623)1.73557145
105Increased nuchal translucency (HP:0010880)1.72843624
106Hammertoe (HP:0001765)1.72839474
107Neurofibrillary tangles (HP:0002185)1.72725141
108Premature skin wrinkling (HP:0100678)1.70668533
109Relative macrocephaly (HP:0004482)1.70460980
110Calcaneovalgus deformity (HP:0001848)1.70067137
111Ectopia lentis (HP:0001083)1.69443724
112Follicular hyperkeratosis (HP:0007502)1.68934914
113Distal upper limb amyotrophy (HP:0007149)1.68133207
114Upper limb amyotrophy (HP:0009129)1.68133207
115Hypoplastic ischia (HP:0003175)1.67786135
116Back pain (HP:0003418)1.67559347
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.66791180
118Ulnar bowing (HP:0003031)1.66024180
119Spinal rigidity (HP:0003306)1.65943873
120Dislocated radial head (HP:0003083)1.65898985
121Severe visual impairment (HP:0001141)1.65750874
122Elfin facies (HP:0004428)1.65585879
123Breech presentation (HP:0001623)1.65476368
124Abnormality of the peritoneum (HP:0002585)1.65158978
125Limited elbow extension (HP:0001377)1.65004489
126Protruding ear (HP:0000411)1.64744465
127Scanning speech (HP:0002168)1.64532434
128Rhizomelia (HP:0008905)1.63636591
129Abnormality of dentin (HP:0010299)1.61669128
130Abnormality of liposaccharide metabolism (HP:0010968)1.61513877
131Abnormality of glycosphingolipid metabolism (HP:0004343)1.61513877
132Abnormality of glycolipid metabolism (HP:0010969)1.61513877
133Broad palm (HP:0001169)1.61501820
134Narrow palate (HP:0000189)1.60701266
135Ankyloglossia (HP:0010296)1.60462013
136Lower limb amyotrophy (HP:0007210)1.60439705
137Retinitis pigmentosa (HP:0000510)1.60428326
138Hand muscle atrophy (HP:0009130)1.60030100
139Mildly elevated creatine phosphokinase (HP:0008180)1.59472554
140Coxa vara (HP:0002812)1.59414220
141Small epiphyses (HP:0010585)1.59326441
142Broad thumb (HP:0011304)1.59211255
143Polar cataract (HP:0010696)1.58731816
144Broad ribs (HP:0000885)1.58554720
145Deviation of the hallux (HP:0010051)1.58301316
146Hallux valgus (HP:0001822)1.57670154
147Decreased electroretinogram (ERG) amplitude (HP:0000654)1.57155061
148Increased connective tissue (HP:0009025)1.54837399
149Fragile skin (HP:0001030)1.54256971
150Increased CSF protein (HP:0002922)1.52693727
151Cervical subluxation (HP:0003308)1.52556145
152Hyperextensible skin (HP:0000974)1.52140438
153Hypoplasia of the iris (HP:0007676)1.50633486
154Action tremor (HP:0002345)1.50626405
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.49998978
156Disinhibition (HP:0000734)1.48622346
157Glomerulonephritis (HP:0000099)1.47142934
158Absent frontal sinuses (HP:0002688)1.46401122
159Broad long bones (HP:0005622)1.46239764
160Hyperacusis (HP:0010780)1.44116633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.06756563
2CAMK1D3.96425807
3CAMK1G3.53949507
4CDK123.23205819
5TRIB32.67692165
6TYRO32.65027820
7ICK2.51222291
8LATS12.32175562
9NTRK12.31012860
10FGFR42.22274554
11DDR22.18154557
12SIK12.10095571
13MAP3K102.09877991
14EPHB11.95967381
15GRK11.89266248
16SMG11.86158424
17PDGFRA1.80519037
18TTN1.74122257
19PAK21.68232042
20PAK41.68033909
21PKN21.67287708
22EEF2K1.65989220
23CSF1R1.65040020
24PDGFRB1.57767277
25PDK21.54907541
26RIPK11.54408777
27MYLK1.53973817
28DMPK1.36927222
29STK31.26843809
30MTOR1.26223918
31PTK61.22096673
32STK101.21587391
33ERBB41.21238412
34PRKD31.20555782
35KSR21.19838154
36RPS6KA41.18644949
37SIK21.14681908
38PRPF4B1.14396434
39TIE11.12683521
40FES1.11485565
41CSK1.08862908
42CDK61.08288291
43CDC42BPA1.08266591
44MST1R1.07758066
45MAPK71.02428369
46ERN11.00405046
47WNK10.99189427
48CDC70.98624185
49MAPK150.96801768
50MAP3K90.96392600
51MAP3K130.95462355
52IRAK20.95130454
53NEK90.94119647
54JAK10.92744803
55MOS0.91605768
56CDK90.90556401
57PBK0.88097158
58PTK2B0.85942669
59ROCK20.83042875
60NEK20.81828719
61MAPK120.81263395
62BMX0.76466678
63RET0.76309564
64MET0.76043545
65PTK20.74917919
66CDK150.73189349
67BRD40.72196975
68CDK11A0.69508888
69ERBB20.69081668
70PRKAA20.68247457
71STK38L0.68197181
72PRKD10.68027529
73FGFR20.67830005
74CDK180.65781241
75PAK60.65722716
76GSK3A0.64905544
77ARAF0.63361444
78SCYL20.61524712
79MELK0.61156417
80* INSR0.59928697
81MARK20.59510758
82LATS20.59433399
83HCK0.58965046
84AKT20.58548858
85CHUK0.58499602
86CHEK10.56500386
87MAP3K80.53945703
88SGK30.53622205
89TYK20.53478166
90ROCK10.52597288
91BRSK10.52208577
92MARK30.51500753
93TSSK60.50992132
94LRRK20.50630296
95FGFR30.50316696
96MKNK10.49785565
97CDK70.49770081
98CDK140.48627485
99PRKG20.48289490
100STK380.48128090
101NTRK30.48052506
102TRPM70.47967611
103TBK10.47967586
104ALK0.47600302
105TTK0.47101571
106UHMK10.47063217
107CAMK40.46934933
108PRKCH0.46720634
109NUAK10.46706452
110BRAF0.46701525
111PIK3CA0.46642626
112CDK40.46266730
113FGFR10.46122065
114SRC0.45676801
115CLK10.43880716
116EGFR0.43608997
117CAMK2B0.42870687
118AKT30.42245180
119EPHB20.42036925
120CAMK2G0.40740273
121MAPKAPK20.39980481
122CDK20.39650847
123PAK30.39642068
124PRKD20.39641370
125* CDK10.39605688
126IGF1R0.39587635
127CSNK1E0.38696135
128PNCK0.38075560
129CSNK1D0.38008433
130MAP3K60.37592243
131FGR0.36699519
132GRK70.36479580
133LMTK20.36085706
134EPHA20.35941380
135EPHA40.35426089
136FER0.35228115
137GSK3B0.35057868
138MAPK10.34866114
139ITK0.32328597
140MAPK100.30987260
141PDK10.30766757
142FYN0.30578169
143PLK20.29832461
144PDPK10.29765837

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.73426977
2ECM-receptor interaction_Homo sapiens_hsa045122.06759801
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81201487
4Adherens junction_Homo sapiens_hsa045201.80595680
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.80120405
6Focal adhesion_Homo sapiens_hsa045101.72485687
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71558817
8Complement and coagulation cascades_Homo sapiens_hsa046101.63143942
9Osteoclast differentiation_Homo sapiens_hsa043801.42970111
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40484226
11Chronic myeloid leukemia_Homo sapiens_hsa052201.39392857
12Viral myocarditis_Homo sapiens_hsa054161.39184798
13Small cell lung cancer_Homo sapiens_hsa052221.39154785
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38339230
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38167751
16Long-term potentiation_Homo sapiens_hsa047201.33451558
17Proteoglycans in cancer_Homo sapiens_hsa052051.29715736
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.27602414
19Gap junction_Homo sapiens_hsa045401.26236772
20Thyroid hormone synthesis_Homo sapiens_hsa049181.24928244
21Pancreatic cancer_Homo sapiens_hsa052121.22944131
22Renal cell carcinoma_Homo sapiens_hsa052111.22781231
23Amoebiasis_Homo sapiens_hsa051461.22139503
24TGF-beta signaling pathway_Homo sapiens_hsa043501.20505762
25Fatty acid biosynthesis_Homo sapiens_hsa000611.18350045
26B cell receptor signaling pathway_Homo sapiens_hsa046621.17772981
27Notch signaling pathway_Homo sapiens_hsa043301.17419592
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17178031
29MicroRNAs in cancer_Homo sapiens_hsa052061.16946644
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12532655
31Thyroid cancer_Homo sapiens_hsa052161.12188097
32Platelet activation_Homo sapiens_hsa046111.12068182
33Toxoplasmosis_Homo sapiens_hsa051451.11848984
34Hippo signaling pathway_Homo sapiens_hsa043901.07826959
35Other glycan degradation_Homo sapiens_hsa005111.05879358
36mTOR signaling pathway_Homo sapiens_hsa041501.05817864
37Bile secretion_Homo sapiens_hsa049761.05405461
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04907817
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.04643071
40Colorectal cancer_Homo sapiens_hsa052101.04594289
41Dilated cardiomyopathy_Homo sapiens_hsa054141.03478964
42Vitamin B6 metabolism_Homo sapiens_hsa007501.03464369
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03006399
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02013181
45PPAR signaling pathway_Homo sapiens_hsa033201.00633834
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00129784
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99026499
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97934327
49Glioma_Homo sapiens_hsa052140.96144668
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96014540
51Lysosome_Homo sapiens_hsa041420.95615262
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95587056
53Melanogenesis_Homo sapiens_hsa049160.92976232
54Staphylococcus aureus infection_Homo sapiens_hsa051500.92233983
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92115064
56Nitrogen metabolism_Homo sapiens_hsa009100.91850282
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91033328
58Dorso-ventral axis formation_Homo sapiens_hsa043200.90905693
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90784470
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90342075
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.89577515
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89192633
63Protein digestion and absorption_Homo sapiens_hsa049740.88764569
64GnRH signaling pathway_Homo sapiens_hsa049120.88694105
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87498637
66Pathways in cancer_Homo sapiens_hsa052000.86403805
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85777739
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85619197
69Prion diseases_Homo sapiens_hsa050200.85090274
70Rap1 signaling pathway_Homo sapiens_hsa040150.85086061
71Insulin signaling pathway_Homo sapiens_hsa049100.84802668
72Malaria_Homo sapiens_hsa051440.84620007
73ErbB signaling pathway_Homo sapiens_hsa040120.84470327
74Bladder cancer_Homo sapiens_hsa052190.83786364
75Endocytosis_Homo sapiens_hsa041440.83030947
76Chemokine signaling pathway_Homo sapiens_hsa040620.82994702
77Prostate cancer_Homo sapiens_hsa052150.82386853
78Arginine biosynthesis_Homo sapiens_hsa002200.81127214
79Axon guidance_Homo sapiens_hsa043600.80693142
80Biosynthesis of amino acids_Homo sapiens_hsa012300.79114176
81Leishmaniasis_Homo sapiens_hsa051400.78996500
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.78721408
83Gastric acid secretion_Homo sapiens_hsa049710.78157012
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77358668
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76618443
86Cell cycle_Homo sapiens_hsa041100.76591338
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75499721
88Renin secretion_Homo sapiens_hsa049240.75482434
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.75209279
90Estrogen signaling pathway_Homo sapiens_hsa049150.74825297
91Glucagon signaling pathway_Homo sapiens_hsa049220.73659553
92* Tight junction_Homo sapiens_hsa045300.73493263
93Lysine degradation_Homo sapiens_hsa003100.73249652
94VEGF signaling pathway_Homo sapiens_hsa043700.72229959
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71673820
96TNF signaling pathway_Homo sapiens_hsa046680.71217446
97Arginine and proline metabolism_Homo sapiens_hsa003300.70637670
98HTLV-I infection_Homo sapiens_hsa051660.70409911
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69873484
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69577543
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.69253604
102HIF-1 signaling pathway_Homo sapiens_hsa040660.69024992
103Histidine metabolism_Homo sapiens_hsa003400.68426063
104Choline metabolism in cancer_Homo sapiens_hsa052310.68090203
105Basal cell carcinoma_Homo sapiens_hsa052170.67909138
106AMPK signaling pathway_Homo sapiens_hsa041520.67907947
107Insulin resistance_Homo sapiens_hsa049310.67354789
108Hedgehog signaling pathway_Homo sapiens_hsa043400.67326840
109Renin-angiotensin system_Homo sapiens_hsa046140.67317759
110Cholinergic synapse_Homo sapiens_hsa047250.66641000
111Inositol phosphate metabolism_Homo sapiens_hsa005620.66525391
112Endometrial cancer_Homo sapiens_hsa052130.65986710
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65830667
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.64661978
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.64651488
116Salmonella infection_Homo sapiens_hsa051320.62875796
117Ras signaling pathway_Homo sapiens_hsa040140.62397200
118Tuberculosis_Homo sapiens_hsa051520.62344663
119Hepatitis B_Homo sapiens_hsa051610.62110303
120Non-small cell lung cancer_Homo sapiens_hsa052230.62042582
121Melanoma_Homo sapiens_hsa052180.60697670
122mRNA surveillance pathway_Homo sapiens_hsa030150.60527238
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60299963
124Oocyte meiosis_Homo sapiens_hsa041140.57662015
125Pertussis_Homo sapiens_hsa051330.57499034
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57085581
127Shigellosis_Homo sapiens_hsa051310.56030676
128Wnt signaling pathway_Homo sapiens_hsa043100.55872696
129Ether lipid metabolism_Homo sapiens_hsa005650.55441395
130Oxytocin signaling pathway_Homo sapiens_hsa049210.55421978
131Viral carcinogenesis_Homo sapiens_hsa052030.55419722
132MAPK signaling pathway_Homo sapiens_hsa040100.55400218
133cAMP signaling pathway_Homo sapiens_hsa040240.55254789
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55007169
135Galactose metabolism_Homo sapiens_hsa000520.54367743
136Type II diabetes mellitus_Homo sapiens_hsa049300.53897772
137Acute myeloid leukemia_Homo sapiens_hsa052210.53566561
138Apoptosis_Homo sapiens_hsa042100.53430322
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52044452
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.50149338

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