ENTPD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.16592625
2dermatan sulfate biosynthetic process (GO:0030208)5.52058087
3chondroitin sulfate catabolic process (GO:0030207)5.41479257
4dermatan sulfate metabolic process (GO:0030205)5.35278793
5proline metabolic process (GO:0006560)5.08246824
6proline biosynthetic process (GO:0006561)4.91142193
7blood vessel maturation (GO:0001955)4.87058466
8peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.66152186
9homocysteine metabolic process (GO:0050667)4.59466758
10peripheral nervous system axon ensheathment (GO:0032292)4.46759790
11myelination in peripheral nervous system (GO:0022011)4.46759790
12negative regulation of complement activation (GO:0045916)4.19689895
13very-low-density lipoprotein particle assembly (GO:0034379)4.18432306
14alanine transport (GO:0032328)4.18412512
15low-density lipoprotein particle remodeling (GO:0034374)4.00368985
16plasma lipoprotein particle assembly (GO:0034377)3.98266575
17bundle of His cell to Purkinje myocyte communication (GO:0086069)3.97320361
18cellular response to cadmium ion (GO:0071276)3.89144038
19protein retention in ER lumen (GO:0006621)3.80464095
20extracellular fibril organization (GO:0043206)3.79907838
21cellular response to nitric oxide (GO:0071732)3.76191084
22L-serine transport (GO:0015825)3.74802800
23peptidyl-tyrosine autophosphorylation (GO:0038083)3.73477651
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.70025122
25lung epithelium development (GO:0060428)3.67950299
26regulation of bile acid biosynthetic process (GO:0070857)3.66779265
27COPI coating of Golgi vesicle (GO:0048205)3.64667672
28Golgi transport vesicle coating (GO:0048200)3.64667672
29protein carboxylation (GO:0018214)3.64163538
30peptidyl-glutamic acid carboxylation (GO:0017187)3.64163538
31branching involved in mammary gland duct morphogenesis (GO:0060444)3.63118904
32intestinal absorption (GO:0050892)3.63099259
33regulation of cholesterol metabolic process (GO:0090181)3.63086408
34regulation of extracellular matrix disassembly (GO:0010715)3.62167023
35intestinal cholesterol absorption (GO:0030299)3.58614024
36protein-lipid complex assembly (GO:0065005)3.57090363
37hemidesmosome assembly (GO:0031581)3.55472351
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.53907998
39glial cell proliferation (GO:0014009)3.53541825
40negative regulation of protein activation cascade (GO:2000258)3.53192859
41sulfur compound catabolic process (GO:0044273)3.50418145
42cellular response to cholesterol (GO:0071397)3.48444602
43glucose 6-phosphate metabolic process (GO:0051156)3.44550798
44positive regulation of synapse maturation (GO:0090129)3.44207860
45keratan sulfate catabolic process (GO:0042340)3.42075698
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.39244940
47positive regulation of cellular amide metabolic process (GO:0034250)3.35388115
48activation of Rac GTPase activity (GO:0032863)3.33902932
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.33841979
50regulation of cholesterol esterification (GO:0010872)3.31808241
51cytoskeletal anchoring at plasma membrane (GO:0007016)3.30868369
52positive regulation of triglyceride biosynthetic process (GO:0010867)3.30161814
53regulation of water loss via skin (GO:0033561)3.25961087
54C4-dicarboxylate transport (GO:0015740)3.24565940
55cell-cell junction maintenance (GO:0045217)3.24081773
56glutamine family amino acid biosynthetic process (GO:0009084)3.23410286
57negative regulation of astrocyte differentiation (GO:0048712)3.23091953
58semaphorin-plexin signaling pathway (GO:0071526)3.19380467
59regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.19210489
60regulation of fatty acid beta-oxidation (GO:0031998)3.18206289
61negative regulation of fatty acid transport (GO:2000192)3.18002758
62multicellular organismal water homeostasis (GO:0050891)3.17179303
63chondroitin sulfate biosynthetic process (GO:0030206)3.16528204
64epithelial cell-cell adhesion (GO:0090136)3.14316682
65serine transport (GO:0032329)3.13690647
66negative regulation of sodium ion transport (GO:0010766)3.11082057
674-hydroxyproline metabolic process (GO:0019471)3.10103105
68positive regulation of fatty acid beta-oxidation (GO:0032000)3.09708110
69positive regulation of cellular amine metabolic process (GO:0033240)3.08713941
70regulation of apoptotic cell clearance (GO:2000425)3.08040665
71positive regulation of glycogen biosynthetic process (GO:0045725)3.07517969
72endothelial cell chemotaxis (GO:0035767)3.06327513
73cellular response to reactive nitrogen species (GO:1902170)3.06292453
74biotin metabolic process (GO:0006768)3.05836155
75cellular response to sterol (GO:0036315)3.05260509
76protein heterotrimerization (GO:0070208)3.05245425
77negative regulation of cardiac muscle tissue growth (GO:0055022)3.04237229
78negative regulation of heart growth (GO:0061117)3.04237229
79cellular sodium ion homeostasis (GO:0006883)3.04028883
80fibril organization (GO:0097435)2.96544137
81maintenance of gastrointestinal epithelium (GO:0030277)2.96380867
82phosphate ion homeostasis (GO:0055062)2.95901629
83trivalent inorganic anion homeostasis (GO:0072506)2.95901629
84negative regulation of cell size (GO:0045792)2.94584048
85sodium ion export (GO:0071436)2.93232773
86myelin maintenance (GO:0043217)2.92906257
87plasma lipoprotein particle organization (GO:0071827)2.91906797
88positive regulation of hormone metabolic process (GO:0032352)2.89601482
89negative regulation of fibrinolysis (GO:0051918)2.88752871
90receptor catabolic process (GO:0032801)2.88140621
91cGMP-mediated signaling (GO:0019934)2.87814311
92high-density lipoprotein particle remodeling (GO:0034375)2.87554405
93reverse cholesterol transport (GO:0043691)2.86711404
94basement membrane organization (GO:0071711)2.86422448
95embryonic retina morphogenesis in camera-type eye (GO:0060059)2.83847813
96sulfur amino acid catabolic process (GO:0000098)2.83681996
97positive regulation of fatty acid oxidation (GO:0046321)2.83255549
98cellular zinc ion homeostasis (GO:0006882)2.82912369
99regulation of triglyceride biosynthetic process (GO:0010866)2.81733328
100diacylglycerol metabolic process (GO:0046339)2.80313194
101GDP-mannose metabolic process (GO:0019673)2.79867987
102positive regulation of extracellular matrix organization (GO:1903055)2.78707786
103ovulation cycle (GO:0042698)2.77354355
104protein-lipid complex subunit organization (GO:0071825)2.75893093
105cholesterol efflux (GO:0033344)2.74492664
106phospholipid efflux (GO:0033700)2.73989487
107positive regulation of steroid biosynthetic process (GO:0010893)2.73609707
108negative regulation of stress fiber assembly (GO:0051497)2.73527978
109endocardial cushion morphogenesis (GO:0003203)2.73401551
110positive regulation of Cdc42 GTPase activity (GO:0043089)2.72236096
111glomerular basement membrane development (GO:0032836)2.71516742
112establishment of skin barrier (GO:0061436)2.70713095
113dicarboxylic acid biosynthetic process (GO:0043650)2.69997573
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.69686354
115response to nitric oxide (GO:0071731)2.69365845
116regulation of cholesterol biosynthetic process (GO:0045540)2.68170788
117positive regulation of glycogen metabolic process (GO:0070875)2.67797262
118regulation of beta-amyloid formation (GO:1902003)2.67728001
119negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.66148534
120hormone catabolic process (GO:0042447)2.64458664
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64361724
122cell communication by electrical coupling (GO:0010644)2.63425596
123renal absorption (GO:0070293)2.63104456
124focal adhesion assembly (GO:0048041)2.63002985
125cell-substrate adherens junction assembly (GO:0007045)2.63002985
126amino acid import (GO:0043090)2.62502418
127cholesterol catabolic process (GO:0006707)2.60976125
128sterol catabolic process (GO:0016127)2.60976125
129NADH metabolic process (GO:0006734)2.60680669
130cellular potassium ion homeostasis (GO:0030007)2.59699736
131glutamate metabolic process (GO:0006536)2.59256612
132L-phenylalanine metabolic process (GO:0006558)2.59063605
133erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.59063605
134response to gravity (GO:0009629)2.57576232
135cell-substrate junction assembly (GO:0007044)2.56868607
136water homeostasis (GO:0030104)2.56866966
137negative regulation of humoral immune response (GO:0002921)2.56713198
138adherens junction assembly (GO:0034333)2.54050307
139renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.53664352
140plasma lipoprotein particle remodeling (GO:0034369)2.53443409
141protein-lipid complex remodeling (GO:0034368)2.53443409
142macromolecular complex remodeling (GO:0034367)2.53443409
143regulation of extracellular matrix organization (GO:1903053)2.53393526
144insulin-like growth factor receptor signaling pathway (GO:0048009)2.53168910
145regulation of complement activation (GO:0030449)2.52374713
146cell junction maintenance (GO:0034331)2.51543023
147low-density lipoprotein particle clearance (GO:0034383)2.51475558
148glycosaminoglycan catabolic process (GO:0006027)2.50980064
149cellular response to epidermal growth factor stimulus (GO:0071364)2.50913351
150vitamin transmembrane transport (GO:0035461)2.50020428
151positive regulation of triglyceride metabolic process (GO:0090208)2.48994866
152negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.47094025
153L-amino acid import (GO:0043092)2.47053308
154regulation of plasminogen activation (GO:0010755)2.44319300
155fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.44197680
156positive regulation of lipid catabolic process (GO:0050996)2.43544359
157regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.43485959
158alpha-linolenic acid metabolic process (GO:0036109)2.43296548
159fructose metabolic process (GO:0006000)2.42909457
160regulation of synapse maturation (GO:0090128)2.42288498
161epithelial structure maintenance (GO:0010669)2.41105301
162apoptotic process involved in morphogenesis (GO:0060561)2.41035906
163extracellular matrix assembly (GO:0085029)2.39194270
164aminoglycan catabolic process (GO:0006026)2.38619768
165potassium ion import (GO:0010107)2.38523576
166glomerulus development (GO:0032835)2.37501891
167bone trabecula formation (GO:0060346)2.37217575
168retina vasculature morphogenesis in camera-type eye (GO:0061299)2.36308521
169positive regulation of fatty acid metabolic process (GO:0045923)2.36225119
170response to leptin (GO:0044321)2.36139500
171regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35918050
172negative regulation of response to reactive oxygen species (GO:1901032)2.35517363
173complement activation, alternative pathway (GO:0006957)2.33726058
174cellular modified amino acid catabolic process (GO:0042219)2.33499002
175regulation of protein activation cascade (GO:2000257)2.31983530
176regulation of phospholipid biosynthetic process (GO:0071071)2.30037921
177regulation of cholesterol homeostasis (GO:2000188)2.28783360
178daunorubicin metabolic process (GO:0044597)2.28223025
179polyketide metabolic process (GO:0030638)2.28223025
180doxorubicin metabolic process (GO:0044598)2.28223025
181regulation of astrocyte differentiation (GO:0048710)2.28199367
182positive regulation of steroid metabolic process (GO:0045940)2.27141068
183regulation of fatty acid oxidation (GO:0046320)2.26908338
184cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.26566663
185ventricular cardiac muscle cell action potential (GO:0086005)2.24477919
186barbed-end actin filament capping (GO:0051016)2.24031278
187regulation of amyloid precursor protein catabolic process (GO:1902991)2.23377074
188collagen fibril organization (GO:0030199)2.23267341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.57019341
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.55263208
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.84678574
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60731890
5AR_21572438_ChIP-Seq_LNCaP_Human2.54543121
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.46329921
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39226237
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.37344932
9CLOCK_20551151_ChIP-Seq_293T_Human2.35765372
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35059791
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31533795
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.26373440
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23749967
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.14044183
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.06801435
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.05825643
17RUNX1_27514584_Chip-Seq_MCF-7_Human2.01700891
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01355185
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93532393
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91677642
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91677642
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91669965
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89924742
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89794223
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85198387
26* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84727272
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82939536
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76253750
29* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74721268
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.71853263
31DROSHA_22980978_ChIP-Seq_HELA_Human1.70888809
32TCF7_22412390_ChIP-Seq_EML_Mouse1.70292585
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69831194
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.69315949
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68695467
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.66915066
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.66302852
38CREB1_26743006_Chip-Seq_LNCaP_Human1.63936213
39SMC4_20622854_ChIP-Seq_HELA_Human1.62837014
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61918786
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60584665
42P68_20966046_ChIP-Seq_HELA_Human1.57532401
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56780955
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56189944
45CJUN_26792858_Chip-Seq_BT549_Human1.54800848
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53824731
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52396363
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52131555
49* RNF2_27304074_Chip-Seq_ESCs_Mouse1.50078022
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49504655
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49181277
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48567834
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.48103205
54GATA1_22025678_ChIP-Seq_K562_Human1.47429688
55GATA6_25053715_ChIP-Seq_YYC3_Human1.47379679
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47177696
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47086222
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46753307
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.43990905
60* TET1_21451524_ChIP-Seq_MESCs_Mouse1.43129276
61ATF3_27146783_Chip-Seq_COLON_Human1.42701666
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.39501584
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39166914
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38200191
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.38159863
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.36561995
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36506928
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.34557073
69MYC_22102868_ChIP-Seq_BL_Human1.31660821
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30876198
71KDM2B_26808549_Chip-Seq_DND41_Human1.30206598
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30058138
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29592290
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27982693
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25511479
76* CTCF_27219007_Chip-Seq_Bcells_Human1.25425258
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24461215
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.24415262
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.24203078
80BCAT_22108803_ChIP-Seq_LS180_Human1.23358607
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23099647
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22818262
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.22032659
84* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21755156
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.21720280
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21038414
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20988085
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20833997
89VDR_21846776_ChIP-Seq_THP-1_Human1.20776412
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20557497
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16805349
92ZNF263_19887448_ChIP-Seq_K562_Human1.15895958
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15033683
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10171519
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10171519
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09801316
97TP53_22127205_ChIP-Seq_IMR90_Human1.09567490
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08550668
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07086052
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.06984051
101BCOR_27268052_Chip-Seq_Bcells_Human1.06898479
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.06711751
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06299073
104TP53_16413492_ChIP-PET_HCT116_Human1.06124365
105TBX20_22328084_ChIP-Seq_HEART_Mouse1.05533855
106TBX20_22080862_ChIP-Seq_HEART_Mouse1.05533855
107TP53_18474530_ChIP-ChIP_U2OS_Human1.03756507
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03416232
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03348520
110* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02909260
111IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02017792
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02006028
113SOX2_20726797_ChIP-Seq_SW620_Human1.01826581
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01402839
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.01138537
116GATA3_24758297_ChIP-Seq_MCF-7_Human1.00844383
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00600678
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00309721
119GATA4_25053715_ChIP-Seq_YYC3_Human0.99449534
120TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98617273
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98368534
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98194553
123JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98145378
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97728434
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97128967
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96941052
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96553818
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.96153015
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96138886
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95437977
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95159613
132STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95086735
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93412600
134RARA_24833708_ChIP-Seq_LIVER_Mouse0.93127661
135SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92417713
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91625034
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91581600
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91573123
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.91516328
140AHR_22903824_ChIP-Seq_MCF-7_Human0.90518025
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90378759
142RXR_22108803_ChIP-Seq_LS180_Human0.89249505
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87157877
144SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86711786
145LXR_22292898_ChIP-Seq_THP-1_Human0.86324363
146* KLF5_25053715_ChIP-Seq_YYC3_Human0.85879387
147GBX2_23144817_ChIP-Seq_PC3_Human0.85416776
148TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85347015
149TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84462854
150* RACK7_27058665_Chip-Seq_MCF-7_Human0.83335769
151WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82614976
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81878887
153* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80960674
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.79605761
155* KDM2B_26808549_Chip-Seq_K562_Human0.79568498
156TP63_22573176_ChIP-Seq_HFKS_Human0.79011102
157* FOXA2_19822575_ChIP-Seq_HepG2_Human0.78705169
158EZH2_22144423_ChIP-Seq_EOC_Human0.77671061
159* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76762579
160JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76115573
161DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75755256
162JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75167198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.26333541
2MP0005503_abnormal_tendon_morphology5.56296787
3MP0010234_abnormal_vibrissa_follicle5.53599730
4MP0005275_abnormal_skin_tensile4.57817326
5MP0004264_abnormal_extraembryonic_tissu3.74165183
6MP0002254_reproductive_system_inflammat3.02476601
7MP0005409_darkened_coat_color2.86097531
8MP0003123_paternal_imprinting2.83277502
9MP0000751_myopathy2.80829754
10MP0001666_abnormal_nutrient_absorption2.77150768
11MP0003183_abnormal_peptide_metabolism2.67758386
12MP0001958_emphysema2.58670089
13MP0003279_aneurysm2.50822289
14MP0005451_abnormal_body_composition2.49876978
15MP0004272_abnormal_basement_membrane2.45535300
16MP0002098_abnormal_vibrissa_morphology2.35401164
17MP0009840_abnormal_foam_cell2.31746582
18MP0003690_abnormal_glial_cell2.23268636
19MP0003878_abnormal_ear_physiology2.23039082
20MP0005377_hearing/vestibular/ear_phenot2.23039082
21MP0004858_abnormal_nervous_system2.18381457
22MP0006054_spinal_hemorrhage2.15341019
23MP0005076_abnormal_cell_differentiation2.15324069
24MP0002108_abnormal_muscle_morphology2.09359371
25MP0009384_cardiac_valve_regurgitation2.04958913
26MP0000579_abnormal_nail_morphology2.04806445
27MP0005083_abnormal_biliary_tract2.01713421
28MP0005058_abnormal_lysosome_morphology2.00931973
29MP0009780_abnormal_chondrocyte_physiolo1.96195127
30MP0000678_abnormal_parathyroid_gland1.82978613
31MP0005257_abnormal_intraocular_pressure1.78756306
32MP0005508_abnormal_skeleton_morphology1.77235438
33MP0003329_amyloid_beta_deposits1.75297366
34MP0001849_ear_inflammation1.72703076
35MP0005332_abnormal_amino_acid1.70955238
36MP0003075_altered_response_to1.70647529
37MP0002060_abnormal_skin_morphology1.69420675
38MP0003011_delayed_dark_adaptation1.68470355
39MP0005501_abnormal_skin_physiology1.67927476
40MP0010678_abnormal_skin_adnexa1.64703120
41MP0003879_abnormal_hair_cell1.63024937
42MP0003453_abnormal_keratinocyte_physiol1.61962377
43MP0005670_abnormal_white_adipose1.58646220
44MP0003191_abnormal_cellular_cholesterol1.57061412
45MP0002653_abnormal_ependyma_morphology1.57016104
46MP0005165_increased_susceptibility_to1.54890178
47MP0005085_abnormal_gallbladder_physiolo1.54271321
48MP0000749_muscle_degeneration1.50282904
49MP0003172_abnormal_lysosome_physiology1.49800033
50MP0000467_abnormal_esophagus_morphology1.49520963
51MP0000750_abnormal_muscle_regeneration1.49099398
52MP0002127_abnormal_cardiovascular_syste1.48168172
53MP0004185_abnormal_adipocyte_glucose1.47742783
54MP0002295_abnormal_pulmonary_circulatio1.46514781
55MP0003705_abnormal_hypodermis_morpholog1.44446932
56MP0004381_abnormal_hair_follicle1.43863058
57MP0003122_maternal_imprinting1.40324691
58MP0001348_abnormal_lacrimal_gland1.38353936
59MP0003646_muscle_fatigue1.37012611
60MP0005646_abnormal_pituitary_gland1.34741099
61MP0004130_abnormal_muscle_cell1.33421452
62MP0001765_abnormal_ion_homeostasis1.33314888
63MP0002249_abnormal_larynx_morphology1.29078008
64MP0000013_abnormal_adipose_tissue1.28092640
65MP0005595_abnormal_vascular_smooth1.27450810
66MP0001216_abnormal_epidermal_layer1.24521238
67MP0004270_analgesia1.24421265
68MP0004885_abnormal_endolymph1.24378820
69MP0004782_abnormal_surfactant_physiolog1.24304193
70MP0002837_dystrophic_cardiac_calcinosis1.22907150
71MP0000383_abnormal_hair_follicle1.22334465
72MP0003136_yellow_coat_color1.19815807
73MP0004215_abnormal_myocardial_fiber1.19098854
74MP0000377_abnormal_hair_follicle1.17938805
75MP0003566_abnormal_cell_adhesion1.17497777
76MP0010368_abnormal_lymphatic_system1.15589168
77MP0000762_abnormal_tongue_morphology1.10275308
78MP0008260_abnormal_autophagy1.08382426
79MP0004036_abnormal_muscle_relaxation1.07721758
80MP0005365_abnormal_bile_salt1.07652286
81MP0002089_abnormal_postnatal_growth/wei1.07484057
82MP0001664_abnormal_digestion1.05244016
83MP0003868_abnormal_feces_composition1.05010036
84MP0000049_abnormal_middle_ear1.04674198
85MP0003634_abnormal_glial_cell1.03613242
86MP0010329_abnormal_lipoprotein_level1.03505403
87MP0005360_urolithiasis1.01889850
88MP0002972_abnormal_cardiac_muscle1.00268698
89MP0000627_abnormal_mammary_gland1.00107440
90MP0008875_abnormal_xenobiotic_pharmacok0.99544079
91MP0001661_extended_life_span0.99064215
92MP0000604_amyloidosis0.97988454
93MP0005167_abnormal_blood-brain_barrier0.97682909
94MP0003252_abnormal_bile_duct0.96758665
95MP0009643_abnormal_urine_homeostasis0.95975975
96MP0005620_abnormal_muscle_contractility0.94178789
97MP0000609_abnormal_liver_physiology0.93627675
98MP0003115_abnormal_respiratory_system0.91773500
99MP0003950_abnormal_plasma_membrane0.90564536
100MP0005330_cardiomyopathy0.90323201
101MP0005666_abnormal_adipose_tissue0.88722285
102MP0002090_abnormal_vision0.87565256
103MP0002896_abnormal_bone_mineralization0.86782867
104MP0000537_abnormal_urethra_morphology0.86106976
105MP0008569_lethality_at_weaning0.85786078
106MP0002822_catalepsy0.85623477
107MP0005636_abnormal_mineral_homeostasis0.84748117
108MP0006138_congestive_heart_failure0.84369697
109MP0009931_abnormal_skin_appearance0.83648345
110MP0000566_synostosis0.83091035
111MP0005369_muscle_phenotype0.82685121
112MP0000534_abnormal_ureter_morphology0.82636936
113MP0003942_abnormal_urinary_system0.82003881
114MP0000477_abnormal_intestine_morphology0.81663372
115MP0003941_abnormal_skin_development0.81365770
116MP0003045_fibrosis0.80933228
117MP0000343_altered_response_to0.80906423
118MP0003137_abnormal_impulse_conducting0.80891720
119MP0010771_integument_phenotype0.80349354
120MP0004019_abnormal_vitamin_homeostasis0.79763438
121MP0003283_abnormal_digestive_organ0.79741951
122MP0000767_abnormal_smooth_muscle0.79121490
123MP0005220_abnormal_exocrine_pancreas0.78687025
124MP0003866_abnormal_defecation0.78617650
125MP0001544_abnormal_cardiovascular_syste0.77794990
126MP0005385_cardiovascular_system_phenoty0.77794990
127MP0005084_abnormal_gallbladder_morpholo0.75665426
128MP0005390_skeleton_phenotype0.75561287
129MP0001984_abnormal_olfaction0.74896802
130MP0001542_abnormal_bone_strength0.74607287
131MP0000428_abnormal_craniofacial_morphol0.74233461
132MP0001853_heart_inflammation0.73743573
133MP0002166_altered_tumor_susceptibility0.73213041
134MP0002909_abnormal_adrenal_gland0.72717661
135MP0000163_abnormal_cartilage_morphology0.72593786
136MP0001299_abnormal_eye_distance/0.72456741
137MP0000003_abnormal_adipose_tissue0.71473107
138MP0002115_abnormal_skeleton_extremities0.70984871
139MP0001346_abnormal_lacrimal_gland0.70868754
140MP0004084_abnormal_cardiac_muscle0.70746051
141MP0004043_abnormal_pH_regulation0.69102507
142MP0004233_abnormal_muscle_weight0.67807132
143MP0005375_adipose_tissue_phenotype0.67677333
144MP0002118_abnormal_lipid_homeostasis0.66767689
145MP0005023_abnormal_wound_healing0.66566856
146MP0003633_abnormal_nervous_system0.66069945
147MP0005164_abnormal_response_to0.66048392
148MP0003943_abnormal_hepatobiliary_system0.65370119
149MP0004087_abnormal_muscle_fiber0.65086802
150MP0002139_abnormal_hepatobiliary_system0.64625013
151MP0005379_endocrine/exocrine_gland_phen0.64106326
152MP0000462_abnormal_digestive_system0.64051485
153MP0000647_abnormal_sebaceous_gland0.63847999
154MP0001243_abnormal_dermal_layer0.63460417
155MP0005408_hypopigmentation0.63290399
156MP0010352_gastrointestinal_tract_polyps0.62073573
157MP0002796_impaired_skin_barrier0.61972065
158MP0000230_abnormal_systemic_arterial0.61351353
159MP0001756_abnormal_urination0.61145569
160MP0009672_abnormal_birth_weight0.60670883
161MP0003638_abnormal_response/metabolism_0.60488950
162MP0001881_abnormal_mammary_gland0.59674874
163MP0000858_altered_metastatic_potential0.58278521
164MP0003315_abnormal_perineum_morphology0.57835856
165MP0002970_abnormal_white_adipose0.54832188
166MP0000538_abnormal_urinary_bladder0.54322793
167MP0002078_abnormal_glucose_homeostasis0.53949282

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)5.74371777
2Deep venous thrombosis (HP:0002625)5.53535839
3Protrusio acetabuli (HP:0003179)4.70636084
4Ankle contracture (HP:0006466)4.57997810
5Amyloidosis (HP:0011034)4.41268880
6Premature rupture of membranes (HP:0001788)4.38217559
7Flat acetabular roof (HP:0003180)4.23876096
8Abnormality of the axillary hair (HP:0100134)4.02019983
9Abnormality of secondary sexual hair (HP:0009888)4.02019983
10Mesangial abnormality (HP:0001966)3.95755088
11Hemorrhage of the eye (HP:0011885)3.91461675
12Neonatal short-limb short stature (HP:0008921)3.85662990
13Aplasia involving bones of the upper limbs (HP:0009823)3.82062299
14Aplasia of the phalanges of the hand (HP:0009802)3.82062299
15Aplasia involving bones of the extremities (HP:0009825)3.82062299
16Thin bony cortex (HP:0002753)3.58515416
17Pili torti (HP:0003777)3.55046488
18Aortic dissection (HP:0002647)3.29794403
19Prolonged partial thromboplastin time (HP:0003645)3.28326654
20Cervical subluxation (HP:0003308)3.18944745
21Advanced eruption of teeth (HP:0006288)3.08372030
22Pulmonary artery stenosis (HP:0004415)3.00908302
23Megalencephaly (HP:0001355)3.00790133
24Neurofibrillary tangles (HP:0002185)2.93161306
25Bronchomalacia (HP:0002780)2.91629650
26Humeroradial synostosis (HP:0003041)2.91343465
27Synostosis involving the elbow (HP:0003938)2.91343465
28Asymmetry of the thorax (HP:0001555)2.89944294
29Follicular hyperkeratosis (HP:0007502)2.88158863
30Hyperglycinuria (HP:0003108)2.86253961
31Abnormality of carpal bone ossification (HP:0006257)2.85155169
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.81437302
33Abnormal tarsal ossification (HP:0008369)2.79258084
34Abnormality of molar (HP:0011077)2.77637734
35Abnormality of molar morphology (HP:0011070)2.77637734
36Exercise-induced myalgia (HP:0003738)2.74101622
37Joint hemorrhage (HP:0005261)2.73749101
38Abnormality of the dental pulp (HP:0006479)2.73597253
39Soft skin (HP:0000977)2.71737904
40Increased connective tissue (HP:0009025)2.69602926
41Abnormal hair laboratory examination (HP:0003328)2.68540455
42Hyperacusis (HP:0010780)2.66497844
43Obstructive sleep apnea (HP:0002870)2.65564044
44Bladder diverticulum (HP:0000015)2.64433731
45Shallow orbits (HP:0000586)2.64282181
46Hypercholesterolemia (HP:0003124)2.62853883
47Back pain (HP:0003418)2.60882822
48Type 1 muscle fiber predominance (HP:0003803)2.60558677
49Hypoalphalipoproteinemia (HP:0003233)2.57840550
50Tarsal synostosis (HP:0008368)2.54337876
51Ketoacidosis (HP:0001993)2.54303821
52Short hallux (HP:0010109)2.49389836
53Vertebral compression fractures (HP:0002953)2.46463936
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.45449035
55Hypoglycemic coma (HP:0001325)2.44911287
56Abnormality of serine family amino acid metabolism (HP:0010894)2.44146161
57Abnormality of glycine metabolism (HP:0010895)2.44146161
58Facial shape deformation (HP:0011334)2.43430498
59Potter facies (HP:0002009)2.43430498
60Abnormality of permanent molar morphology (HP:0011071)2.43312376
61Abnormality of the dental root (HP:0006486)2.43312376
62Taurodontia (HP:0000679)2.43312376
63Septate vagina (HP:0001153)2.41539459
64Wrist flexion contracture (HP:0001239)2.39413741
65Abnormal ossification of hand bones (HP:0005921)2.34618001
66Synostosis involving bones of the feet (HP:0009140)2.33439715
67Synostosis involving bones of the lower limbs (HP:0009138)2.33439715
68Narrow nasal bridge (HP:0000446)2.32236310
69Onycholysis (HP:0001806)2.31972420
70Biconcave vertebral bodies (HP:0004586)2.30265853
71Right ventricular cardiomyopathy (HP:0011663)2.29739284
72Hemiplegia (HP:0002301)2.29242877
73Pterygium (HP:0001059)2.28707911
74Xanthomatosis (HP:0000991)2.28696741
75Muscle fiber splitting (HP:0003555)2.28202797
76Asymmetric septal hypertrophy (HP:0001670)2.28006264
77Abnormal hand bone ossification (HP:0010660)2.27354603
78Aplasia/Hypoplasia of the hallux (HP:0008362)2.26939219
79Abdominal distention (HP:0003270)2.26354392
80Glomerulonephritis (HP:0000099)2.26130728
81Atrophic scars (HP:0001075)2.24172955
82Hypobetalipoproteinemia (HP:0003563)2.24031330
83Vascular calcification (HP:0004934)2.23496715
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23037499
85Absent hair (HP:0002298)2.22731563
86Abnormality of the gastric mucosa (HP:0004295)2.22523091
87Complement deficiency (HP:0004431)2.21782181
88J-shaped sella turcica (HP:0002680)2.20977311
89Menorrhagia (HP:0000132)2.19972135
90Delayed epiphyseal ossification (HP:0002663)2.16211192
91Spinal rigidity (HP:0003306)2.16170027
92Mildly elevated creatine phosphokinase (HP:0008180)2.15633526
93Germ cell neoplasia (HP:0100728)2.15393739
94Increased variability in muscle fiber diameter (HP:0003557)2.12183587
95Cerebral inclusion bodies (HP:0100314)2.11947483
96Hydroxyprolinuria (HP:0003080)2.11615496
97Abnormality of proline metabolism (HP:0010907)2.11615496
98Cerebral aneurysm (HP:0004944)2.10872354
99Broad face (HP:0000283)2.10239491
100Abnormality of nail color (HP:0100643)2.10045236
101Abnormality of the common coagulation pathway (HP:0010990)2.08669458
102Neonatal death (HP:0003811)2.08372762
103Systemic lupus erythematosus (HP:0002725)2.07742889
104Hyperinsulinemic hypoglycemia (HP:0000825)2.06244452
105Wide cranial sutures (HP:0010537)2.06189955
106Widely patent fontanelles and sutures (HP:0004492)2.03864205
107Enlarged penis (HP:0000040)2.01577498
108Lymphangioma (HP:0100764)2.01134440
109Aortic aneurysm (HP:0004942)2.00982212
110Milia (HP:0001056)1.99098769
111Premature skin wrinkling (HP:0100678)1.98384930
112Hyperparathyroidism (HP:0000843)1.97948370
113Small epiphyses (HP:0010585)1.97928693
114Ileus (HP:0002595)1.96943835
115Plantar hyperkeratosis (HP:0007556)1.95993649
116Akinesia (HP:0002304)1.93583070
117Hypoglycemic seizures (HP:0002173)1.89991211
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88816701
119Hyperextensible skin (HP:0000974)1.88560901
120Pigmentary retinal degeneration (HP:0001146)1.85724988
121Upper limb amyotrophy (HP:0009129)1.84549778
122Distal upper limb amyotrophy (HP:0007149)1.84549778
123Dysmetric saccades (HP:0000641)1.84290700
124Alopecia of scalp (HP:0002293)1.83330942
125Adactyly (HP:0009776)1.83293413
126Abnormality of complement system (HP:0005339)1.82391967
127Progressive visual loss (HP:0000529)1.81744078
128Gout (HP:0001997)1.81086853
129Abnormality of the middle phalanges of the toes (HP:0010183)1.80550713
130Hypophosphatemia (HP:0002148)1.80411011
131Hyperlipoproteinemia (HP:0010980)1.80022316
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79997721
133Bulbar palsy (HP:0001283)1.78851717
134Hypoplastic left heart (HP:0004383)1.78757068
135Aortic regurgitation (HP:0001659)1.77999802
136Acanthosis nigricans (HP:0000956)1.77868941
137Clumsiness (HP:0002312)1.77817610
138Dilatation of the ascending aorta (HP:0005111)1.77063530
139Testicular atrophy (HP:0000029)1.76482325
140Generalized amyotrophy (HP:0003700)1.76080076
141Hyperglycinemia (HP:0002154)1.76032301
142Intrahepatic cholestasis (HP:0001406)1.75275821
143Mucopolysacchariduria (HP:0008155)1.74504732
144Urinary glycosaminoglycan excretion (HP:0003541)1.74504732
145Ketosis (HP:0001946)1.74370958
146Axonal loss (HP:0003447)1.74252116
147Cardiovascular calcification (HP:0011915)1.74079855
148Stridor (HP:0010307)1.73673819
149Abnormality of the Achilles tendon (HP:0005109)1.72973367
150Amelogenesis imperfecta (HP:0000705)1.72925875
151Bifid scrotum (HP:0000048)1.72348696
152Myotonia (HP:0002486)1.71979259
153Fragile skin (HP:0001030)1.71954030
154Broad ribs (HP:0000885)1.71055313
155Abnormality of the vitreous humor (HP:0004327)1.70839592
156Glomerulosclerosis (HP:0000096)1.70764026
157Abnormal foot bone ossification (HP:0010675)1.70034058
158Epiphyseal dysplasia (HP:0002656)1.69956789
159Lip pit (HP:0100267)1.69066976
160Stroke (HP:0001297)1.68963774
161Abnormal glucose tolerance (HP:0001952)1.68656385
162Flattened epiphyses (HP:0003071)1.68542813
163Diaphragmatic weakness (HP:0009113)1.68457654
164Hypotrichosis (HP:0001006)1.68271509
165Bell-shaped thorax (HP:0001591)1.68230012
166Protuberant abdomen (HP:0001538)1.67940575
167Turricephaly (HP:0000262)1.67923476
168Distal lower limb muscle weakness (HP:0009053)1.67079152
169Hypoplasia of dental enamel (HP:0006297)1.66939667
170Abnormality of polysaccharide metabolism (HP:0011012)1.66872290
171Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66872290
172Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66872290
173Focal segmental glomerulosclerosis (HP:0000097)1.65665441
174Abnormality of the nasal septum (HP:0000419)1.65262721
175Curly hair (HP:0002212)1.64199062
176Segmental peripheral demyelination/remyelination (HP:0003481)1.62249193
177Myopathic facies (HP:0002058)1.61825001
178Sparse lateral eyebrow (HP:0005338)1.61495493
179Insomnia (HP:0100785)1.60782317
180Progressive sensorineural hearing impairment (HP:0000408)1.60736100
181Skin nodule (HP:0200036)1.60506873
182Natal tooth (HP:0000695)1.60497045
183Hypotension (HP:0002615)1.58997902
184Growth hormone excess (HP:0000845)1.58104242
185Micronodular cirrhosis (HP:0001413)1.57731712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.18768891
2LMTK24.94542535
3INSRR4.25657079
4PHKG13.98797400
5PHKG23.98797400
6PRKD32.89738740
7PKN22.83618369
8SIK12.72794505
9TRIB32.61199972
10ERN12.48489731
11SMG12.38415177
12ICK2.33211040
13EPHA42.28901566
14EEF2K2.28558562
15MUSK2.24680296
16BCKDK2.18010527
17CDK122.07826218
18TTN1.92482724
19DDR21.91873565
20CAMK1D1.87943743
21PDGFRA1.73584811
22PINK11.66210046
23MYLK1.65590869
24LATS11.64566203
25TGFBR21.64530980
26PRKD21.61426834
27FGFR31.50496115
28TNIK1.47728135
29CAMK1G1.44344176
30NTRK21.39830299
31STK38L1.36768373
32TAOK11.36610090
33STK241.23586425
34MAP3K21.22676956
35PTK61.17072465
36IRAK31.16693044
37RPS6KB21.16474157
38SIK21.15658967
39RIPK11.13989977
40DMPK1.13380823
41CDC42BPA1.08694419
42MAPK121.06611196
43AKT31.05928807
44NME21.05872370
45ROCK11.05397393
46PDK41.05130714
47PDK31.05130714
48PAK41.04474961
49PDK21.03532477
50MAP2K21.03006811
51MAP3K71.02922836
52FER1.02824159
53PRKG21.02072940
54TESK10.99812008
55RET0.97274954
56MTOR0.96366006
57STK380.95754744
58PRKCI0.95683602
59WNK40.95631222
60BMX0.93951877
61MST40.93261954
62ERBB20.91481909
63MST1R0.91066347
64PRKCH0.91037397
65EIF2AK10.90008345
66MARK20.88436686
67TIE10.87543242
68PDPK10.87498760
69CSK0.80067186
70MET0.78872548
71NEK60.78588158
72PAK30.78484133
73MAP2K60.77848370
74PRKD10.75959923
75PRKAA20.75299489
76SGK20.74637178
77NTRK10.74376626
78SGK4940.73939034
79SGK2230.73939034
80TNK20.73562551
81PRKCE0.72589864
82SGK30.72368955
83EPHB10.72306712
84TRPM70.70161516
85NME10.69898768
86ROCK20.69480536
87DYRK1B0.69014133
88CASK0.67770231
89LATS20.65311194
90NTRK30.63682805
91EPHA30.60504669
92FGFR20.58984119
93PRKAA10.58660083
94MAP3K130.58453094
95MATK0.57834563
96MAPK110.57531581
97MAP3K10.57101623
98RPS6KA20.56925735
99MAP2K10.55313018
100CDK70.55273722
101EPHB20.53618533
102ILK0.52901616
103MAPK130.52210525
104MAP3K60.50776381
105PIK3CA0.50568021
106CAMKK10.50071595
107MAP3K90.49462410
108KSR20.48920968
109PRPF4B0.48517607
110OBSCN0.48440549
111PDGFRB0.46353953
112TYRO30.45886487
113HIPK20.45813688
114MAPK150.43641972
115IRAK10.42981377
116FGFR10.42938603
117SIK30.42713017
118LRRK20.41905487
119IGF1R0.41659962
120MAPK70.41418119
121MAP3K30.40903826
122PDK10.40851028
123NLK0.40743061
124CHUK0.40682689
125WNK10.39906212
126FGR0.39695664
127FGFR40.39140934
128CAMK2G0.38860877
129PAK20.38821982
130MAPKAPK20.37768531
131GRK60.37448538
132PRKACA0.36293238
133PRKACG0.35783725
134AKT20.35643199
135MAP3K100.34928332
136SRC0.34245762
137STK390.34128157
138TAOK30.33464725
139MAPKAPK30.33375637
140PTK20.32956639
141PIK3CG0.32143639
142CAMK2D0.31893606
143CSF1R0.31879033
144ARAF0.30932283
145PRKCA0.30825593
146PRKACB0.30771581
147ADRBK10.30191669
148FRK0.29838627
149CAMK2B0.29134954
150NUAK10.28688565
151MAPK80.28634421
152RPS6KB10.28493118
153TESK20.28327493

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.35610263
2Fatty acid biosynthesis_Homo sapiens_hsa000613.85966205
3Fatty acid degradation_Homo sapiens_hsa000713.06891468
4Fatty acid metabolism_Homo sapiens_hsa012122.76629021
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.63728146
6PPAR signaling pathway_Homo sapiens_hsa033202.34667734
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03515326
8Phenylalanine metabolism_Homo sapiens_hsa003601.95145756
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94810734
10Propanoate metabolism_Homo sapiens_hsa006401.90770689
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71400968
12ECM-receptor interaction_Homo sapiens_hsa045121.68639905
13Protein digestion and absorption_Homo sapiens_hsa049741.66530415
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.66410797
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54043140
16Vitamin digestion and absorption_Homo sapiens_hsa049771.45480733
17Sulfur metabolism_Homo sapiens_hsa009201.44627292
18Steroid biosynthesis_Homo sapiens_hsa001001.40980207
19Notch signaling pathway_Homo sapiens_hsa043301.40919047
20Complement and coagulation cascades_Homo sapiens_hsa046101.30447287
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29643448
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23788101
23Bile secretion_Homo sapiens_hsa049761.23211543
24Insulin signaling pathway_Homo sapiens_hsa049101.20501074
25Mineral absorption_Homo sapiens_hsa049781.17529530
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15967466
27Butanoate metabolism_Homo sapiens_hsa006501.12876998
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12475045
29AMPK signaling pathway_Homo sapiens_hsa041521.12297019
30Sulfur relay system_Homo sapiens_hsa041221.11086934
31Peroxisome_Homo sapiens_hsa041461.10468859
32Caffeine metabolism_Homo sapiens_hsa002321.10417257
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09956281
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09703721
35VEGF signaling pathway_Homo sapiens_hsa043701.09631149
36Glycerolipid metabolism_Homo sapiens_hsa005611.08848827
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.08708679
38Fatty acid elongation_Homo sapiens_hsa000621.08545191
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.08074191
40Dilated cardiomyopathy_Homo sapiens_hsa054141.07938437
41Arginine and proline metabolism_Homo sapiens_hsa003301.07541741
42beta-Alanine metabolism_Homo sapiens_hsa004101.06883890
43Tryptophan metabolism_Homo sapiens_hsa003801.04741881
44Endometrial cancer_Homo sapiens_hsa052131.04097656
45ErbB signaling pathway_Homo sapiens_hsa040120.99374601
46Fructose and mannose metabolism_Homo sapiens_hsa000510.98755050
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98686588
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97123533
49Estrogen signaling pathway_Homo sapiens_hsa049150.95958890
50Other glycan degradation_Homo sapiens_hsa005110.93882253
51Circadian rhythm_Homo sapiens_hsa047100.93273067
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93185029
53Chemical carcinogenesis_Homo sapiens_hsa052040.92553543
54Arginine biosynthesis_Homo sapiens_hsa002200.92384097
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92243740
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91330142
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90288891
58Dorso-ventral axis formation_Homo sapiens_hsa043200.88061550
59N-Glycan biosynthesis_Homo sapiens_hsa005100.87764422
60Starch and sucrose metabolism_Homo sapiens_hsa005000.85121899
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84902499
62Vibrio cholerae infection_Homo sapiens_hsa051100.82530125
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82519237
64Tyrosine metabolism_Homo sapiens_hsa003500.81933681
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80275802
66Glutathione metabolism_Homo sapiens_hsa004800.80213585
67Focal adhesion_Homo sapiens_hsa045100.79671116
68Insulin resistance_Homo sapiens_hsa049310.79270863
69Tight junction_Homo sapiens_hsa045300.79051869
70Non-small cell lung cancer_Homo sapiens_hsa052230.78948541
71Carbon metabolism_Homo sapiens_hsa012000.78653062
72ABC transporters_Homo sapiens_hsa020100.78287808
73Insulin secretion_Homo sapiens_hsa049110.77711030
74Bladder cancer_Homo sapiens_hsa052190.77633018
75Malaria_Homo sapiens_hsa051440.77129991
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76854146
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76846418
78Fat digestion and absorption_Homo sapiens_hsa049750.76282564
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76229106
80GnRH signaling pathway_Homo sapiens_hsa049120.74989189
81Pancreatic secretion_Homo sapiens_hsa049720.74589305
82mTOR signaling pathway_Homo sapiens_hsa041500.74430618
83Gastric acid secretion_Homo sapiens_hsa049710.74234336
84Pyruvate metabolism_Homo sapiens_hsa006200.73210173
85Choline metabolism in cancer_Homo sapiens_hsa052310.73139512
86Salivary secretion_Homo sapiens_hsa049700.72581505
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72402894
88Chronic myeloid leukemia_Homo sapiens_hsa052200.72053250
89Prion diseases_Homo sapiens_hsa050200.71776509
90Lysine degradation_Homo sapiens_hsa003100.69393785
91Thyroid hormone synthesis_Homo sapiens_hsa049180.68470728
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.68286086
93Basal cell carcinoma_Homo sapiens_hsa052170.67548827
94Galactose metabolism_Homo sapiens_hsa000520.67414996
95Histidine metabolism_Homo sapiens_hsa003400.67385329
96Lysosome_Homo sapiens_hsa041420.66822764
97Inositol phosphate metabolism_Homo sapiens_hsa005620.66506082
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66199361
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65593867
100Renin-angiotensin system_Homo sapiens_hsa046140.64460334
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63945391
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63010658
103Biosynthesis of amino acids_Homo sapiens_hsa012300.62777193
104Hepatitis C_Homo sapiens_hsa051600.61607493
105Thyroid cancer_Homo sapiens_hsa052160.58581691
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58571456
107Acute myeloid leukemia_Homo sapiens_hsa052210.58250347
108Arachidonic acid metabolism_Homo sapiens_hsa005900.57180185
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55882446
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55743483
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55303224
112Glioma_Homo sapiens_hsa052140.55144939
113Cardiac muscle contraction_Homo sapiens_hsa042600.54882025
114Renin secretion_Homo sapiens_hsa049240.54669961
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54202296
116Vitamin B6 metabolism_Homo sapiens_hsa007500.53719548
117Adherens junction_Homo sapiens_hsa045200.52320767
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51881950
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51290173
120Sphingolipid metabolism_Homo sapiens_hsa006000.51060888
121Axon guidance_Homo sapiens_hsa043600.50362048
122Hedgehog signaling pathway_Homo sapiens_hsa043400.50122941
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50114672
124Proteoglycans in cancer_Homo sapiens_hsa052050.50015664
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.49264794
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.48221593
127TGF-beta signaling pathway_Homo sapiens_hsa043500.48048675
128Amoebiasis_Homo sapiens_hsa051460.46808340
129Glucagon signaling pathway_Homo sapiens_hsa049220.46429559
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.46107095
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.44903890
132Cocaine addiction_Homo sapiens_hsa050300.44571606
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44017681
134GABAergic synapse_Homo sapiens_hsa047270.43435000
135HIF-1 signaling pathway_Homo sapiens_hsa040660.43255759
136Melanogenesis_Homo sapiens_hsa049160.43202344
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.42910795
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42184365
139Pentose phosphate pathway_Homo sapiens_hsa000300.42086097
140Pancreatic cancer_Homo sapiens_hsa052120.41430704
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.41326428
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40797177
143Prolactin signaling pathway_Homo sapiens_hsa049170.40430779
144Calcium signaling pathway_Homo sapiens_hsa040200.40286830
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.39500404
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.39250698
147cAMP signaling pathway_Homo sapiens_hsa040240.38701169

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