ENOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)7.86926660
2daunorubicin metabolic process (GO:0044597)7.86926660
3polyketide metabolic process (GO:0030638)7.86926660
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.09400253
5aminoglycoside antibiotic metabolic process (GO:0030647)4.92704105
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.91719555
7cytidine metabolic process (GO:0046087)4.86205068
8cytidine catabolic process (GO:0006216)4.86205068
9cytidine deamination (GO:0009972)4.86205068
10interferon-gamma production (GO:0032609)4.65427472
11maintenance of protein location in nucleus (GO:0051457)4.23918321
12somite rostral/caudal axis specification (GO:0032525)4.20482551
13regulation of MHC class I biosynthetic process (GO:0045343)4.03239113
14muscle organ morphogenesis (GO:0048644)4.02576242
15chromatin remodeling at centromere (GO:0031055)3.92040937
16chaperone-mediated protein transport (GO:0072321)3.89724693
17protein neddylation (GO:0045116)3.89562399
18CENP-A containing nucleosome assembly (GO:0034080)3.85530945
19regulation of mammary gland epithelial cell proliferation (GO:0033599)3.84076644
20coenzyme catabolic process (GO:0009109)3.83380182
21behavioral response to ethanol (GO:0048149)3.83343836
22negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.83128252
23natural killer cell mediated immunity (GO:0002228)3.82462254
24natural killer cell mediated cytotoxicity (GO:0042267)3.82462254
25valine metabolic process (GO:0006573)3.79652494
26positive regulation of defense response to virus by host (GO:0002230)3.72856539
27T-helper 1 type immune response (GO:0042088)3.72822183
28kinetochore assembly (GO:0051382)3.61732536
29substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.61015823
30substrate-independent telencephalic tangential migration (GO:0021826)3.61015823
31protein complex biogenesis (GO:0070271)3.59898032
32negative regulation of cell cycle G2/M phase transition (GO:1902750)3.59611984
33positive regulation of gamma-delta T cell activation (GO:0046645)3.57809673
34kinetochore organization (GO:0051383)3.57207540
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.56403720
36NADH dehydrogenase complex assembly (GO:0010257)3.56403720
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56403720
38mitochondrial respiratory chain complex assembly (GO:0033108)3.55585402
39water-soluble vitamin biosynthetic process (GO:0042364)3.52450726
40negative regulation of epidermis development (GO:0045683)3.51943318
41rRNA transcription (GO:0009303)3.49960382
42centriole replication (GO:0007099)3.49257579
43pyrimidine ribonucleoside catabolic process (GO:0046133)3.46720393
44natural killer cell differentiation (GO:0001779)3.45969569
45cellular modified amino acid catabolic process (GO:0042219)3.40721578
46ganglion development (GO:0061548)3.40151102
47positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.37604760
48positive regulation of natural killer cell differentiation (GO:0032825)3.37338512
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36611803
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36611803
51proteasome assembly (GO:0043248)3.35789345
52NIK/NF-kappaB signaling (GO:0038061)3.35259600
53regulation of apoptotic process involved in morphogenesis (GO:1902337)3.34782530
54immunoglobulin mediated immune response (GO:0016064)3.31861076
55antigen processing and presentation of endogenous antigen (GO:0019883)3.30530386
56hormone catabolic process (GO:0042447)3.30429645
57intraciliary transport (GO:0042073)3.30178251
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28587333
59B cell mediated immunity (GO:0019724)3.27302031
60negative regulation of DNA-dependent DNA replication (GO:2000104)3.24624779
61membrane protein intracellular domain proteolysis (GO:0031293)3.21460253
62positive regulation of growth hormone secretion (GO:0060124)3.20667415
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19780322
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17337383
65metaphase plate congression (GO:0051310)3.16621821
66quinone metabolic process (GO:1901661)3.16156225
67primary alcohol catabolic process (GO:0034310)3.14081022
68base-excision repair, AP site formation (GO:0006285)3.14066563
69positive regulation of protein deacetylation (GO:0090312)3.13224410
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12865691
71negative regulation of interleukin-2 production (GO:0032703)3.12610016
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09639801
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09254002
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08768933
75DNA damage response, detection of DNA damage (GO:0042769)3.07429596
76regulation of DNA endoreduplication (GO:0032875)3.03497274
77striatum development (GO:0021756)3.02881783
78protein heterotetramerization (GO:0051290)3.01645442
79regulation of necroptotic process (GO:0060544)3.00356897
80positive regulation of B cell differentiation (GO:0045579)3.00156819
81inner mitochondrial membrane organization (GO:0007007)2.99775857
82resolution of meiotic recombination intermediates (GO:0000712)2.99434111
83regulation of response to osmotic stress (GO:0047484)2.99231136
84mitotic metaphase plate congression (GO:0007080)2.98419921
85natural killer cell activation (GO:0030101)2.98365797
86regulation of growth hormone secretion (GO:0060123)2.97758674
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97730293
88response to muramyl dipeptide (GO:0032495)2.96595774
89histone exchange (GO:0043486)2.96221922
90regulation of defense response to virus by host (GO:0050691)2.96151188
91positive regulation of histone deacetylation (GO:0031065)2.95098069
92pyrimidine nucleobase catabolic process (GO:0006208)2.93876865
93DNA replication-independent nucleosome assembly (GO:0006336)2.93192302
94DNA replication-independent nucleosome organization (GO:0034724)2.93192302
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92802628
96nucleoside transmembrane transport (GO:1901642)2.92507864
97response to dietary excess (GO:0002021)2.91954646
98histone H4-K8 acetylation (GO:0043982)2.90298434
99histone H4-K5 acetylation (GO:0043981)2.90298434
100behavioral response to nicotine (GO:0035095)2.88492415
101neutrophil activation involved in immune response (GO:0002283)2.87221645
102cofactor catabolic process (GO:0051187)2.86819099
103positive regulation of tissue remodeling (GO:0034105)2.86755353
104protein K6-linked ubiquitination (GO:0085020)2.86396751
105regulation of nuclear cell cycle DNA replication (GO:0033262)2.86255759
106response to peptidoglycan (GO:0032494)2.85790300
107negative regulation of ligase activity (GO:0051352)2.81555457
108negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81555457
109establishment of endothelial barrier (GO:0061028)2.81435975
110intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.81133234
111replication fork processing (GO:0031297)2.78939519
112spindle checkpoint (GO:0031577)2.78504860
113protein targeting to mitochondrion (GO:0006626)2.77976532
114phenol-containing compound catabolic process (GO:0019336)2.77832974
115hepatocyte apoptotic process (GO:0097284)2.77404797
116energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76515175
117ATP synthesis coupled proton transport (GO:0015986)2.76515175
118positive regulation of interleukin-17 production (GO:0032740)2.76162096
119regulation of RIG-I signaling pathway (GO:0039535)2.75646604
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75211516
121transepithelial transport (GO:0070633)2.74717452
122protein K11-linked ubiquitination (GO:0070979)2.74031662
123icosanoid secretion (GO:0032309)2.71341648
124arachidonic acid secretion (GO:0050482)2.71341648
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.70998536
126negative regulation of sister chromatid segregation (GO:0033046)2.70998536
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70998536
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70998536
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70998536
130epoxygenase P450 pathway (GO:0019373)2.70851947
131signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70084326
132signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70084326
133signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70084326
134protein localization to kinetochore (GO:0034501)2.69996353
135positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.69493163
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69341004
137positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69225038
138regulation of interleukin-2 biosynthetic process (GO:0045076)2.67861027
139regulation of gamma-delta T cell activation (GO:0046643)2.67292558
140mitotic spindle assembly checkpoint (GO:0007094)2.66968236
141cellular response to type I interferon (GO:0071357)2.66911655
142type I interferon signaling pathway (GO:0060337)2.66911655
143ubiquinone biosynthetic process (GO:0006744)2.66661471
144magnesium ion transport (GO:0015693)2.66510510
145regulation of dendritic cell antigen processing and presentation (GO:0002604)2.65777337
146regulation of interferon-gamma biosynthetic process (GO:0045072)2.65538160
147synapsis (GO:0007129)2.65472318
148regulation of cellular amino acid metabolic process (GO:0006521)2.65295547
149mitotic spindle checkpoint (GO:0071174)2.64625102
150histone H4-K12 acetylation (GO:0043983)2.64481292
151respiratory electron transport chain (GO:0022904)2.64313940
152signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64150444
153intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64150444
154ubiquinone metabolic process (GO:0006743)2.64095310
155spindle assembly checkpoint (GO:0071173)2.64092789
156positive regulation of alpha-beta T cell proliferation (GO:0046641)2.63820694
157positive regulation of protein import into nucleus, translocation (GO:0033160)2.63719285
158attachment of spindle microtubules to kinetochore (GO:0008608)2.63637631
159rRNA modification (GO:0000154)2.63215279
160response to type I interferon (GO:0034340)2.62980046
161positive regulation of humoral immune response (GO:0002922)2.62516673
162myeloid dendritic cell differentiation (GO:0043011)2.62512208
163DNA double-strand break processing (GO:0000729)2.62429113
164negative regulation of necroptotic process (GO:0060546)2.62129255
165dendritic cell differentiation (GO:0097028)2.61904378
166regulation of gamma-delta T cell differentiation (GO:0045586)2.61802150
167sulfur amino acid catabolic process (GO:0000098)2.61540193
168regulation of cilium movement (GO:0003352)2.61446729
169negative regulation of chromosome segregation (GO:0051985)2.60725865
170regulation of centriole replication (GO:0046599)2.60665700
171electron transport chain (GO:0022900)2.60284733
172regulation of hypersensitivity (GO:0002883)2.59687300
173negative regulation of catecholamine secretion (GO:0033604)2.59168774
174signal transduction involved in cell cycle checkpoint (GO:0072395)2.58603237
175regulation of interleukin-17 production (GO:0032660)2.58109171
176regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.57697365
177regulation of mitotic spindle checkpoint (GO:1903504)2.57697365
178ribonucleoprotein complex disassembly (GO:0032988)2.57010552
179negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.56791691
180lymphocyte mediated immunity (GO:0002449)2.56631098
181intracellular protein transmembrane import (GO:0044743)2.56626675
182DNA ligation (GO:0006266)2.56619520
183hydrogen peroxide biosynthetic process (GO:0050665)2.56462570
184primitive streak formation (GO:0090009)2.56278220
185T cell differentiation involved in immune response (GO:0002292)2.55941487
186alpha-beta T cell differentiation involved in immune response (GO:0002293)2.55941487
187alpha-beta T cell activation involved in immune response (GO:0002287)2.55941487
188signal transduction involved in DNA damage checkpoint (GO:0072422)2.55164237
189signal transduction involved in DNA integrity checkpoint (GO:0072401)2.55164237
190regulation of alpha-beta T cell proliferation (GO:0046640)2.54322061
191tachykinin receptor signaling pathway (GO:0007217)2.54311182
192regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54251022
193single strand break repair (GO:0000012)2.54111292
194organelle disassembly (GO:1903008)2.53534719
195ectoderm development (GO:0007398)2.53006252
196positive regulation of ligase activity (GO:0051351)2.52053664
197neural tube formation (GO:0001841)2.50518068
198sensory perception of smell (GO:0007608)2.48558407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.13372990
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.06240538
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.75042770
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.75042770
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.75042770
6EZH2_22144423_ChIP-Seq_EOC_Human4.73484469
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09470753
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.62711492
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.47652035
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.33078978
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.23886275
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22477265
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18906820
14IRF8_21731497_ChIP-ChIP_J774_Mouse3.11257820
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.98335582
16GATA1_22025678_ChIP-Seq_K562_Human2.93451532
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.88403967
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.84422218
19SCL_19346495_ChIP-Seq_HPC-7_Human2.73360356
20VDR_22108803_ChIP-Seq_LS180_Human2.72878953
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63341495
22ELK1_19687146_ChIP-ChIP_HELA_Human2.61901611
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45823169
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42139181
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.40198290
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28999185
27E2F7_22180533_ChIP-Seq_HELA_Human2.28465632
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24755313
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23394272
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19241619
31* FUS_26573619_Chip-Seq_HEK293_Human2.18827002
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14560655
33* ETS1_20019798_ChIP-Seq_JURKAT_Human2.10392613
34NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.05363439
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02992229
36ZNF274_21170338_ChIP-Seq_K562_Hela2.01921032
37* EWS_26573619_Chip-Seq_HEK293_Human2.01429877
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.96537887
39IRF1_19129219_ChIP-ChIP_H3396_Human1.96309003
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94359472
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92258131
42VDR_23849224_ChIP-Seq_CD4+_Human1.91826176
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91386749
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77421455
45TAF15_26573619_Chip-Seq_HEK293_Human1.77291816
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76126261
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75978864
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75564870
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74739502
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74042809
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.73470223
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73003568
53* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70931430
54SPI1_23547873_ChIP-Seq_NB4_Human1.70443068
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70245665
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69388508
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.69160073
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68478277
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68104672
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67800116
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.64807545
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63996365
63P300_19829295_ChIP-Seq_ESCs_Human1.62695188
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59315924
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58839473
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57535944
67FOXP3_21729870_ChIP-Seq_TREG_Human1.57521868
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.56200089
69ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.55331476
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54588241
71MYC_18940864_ChIP-ChIP_HL60_Human1.54277202
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.53543225
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.52872793
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.52599615
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51526507
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50900478
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46638065
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.45051290
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44973712
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41774458
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40384551
82MYB_26560356_Chip-Seq_TH2_Human1.39373640
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37476129
84IGF1R_20145208_ChIP-Seq_DFB_Human1.37357874
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36809628
86TCF7_22412390_ChIP-Seq_EML_Mouse1.35958691
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.35708060
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35494568
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35287796
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33168369
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31543287
92RNF2_27304074_Chip-Seq_NSC_Mouse1.30682417
93GBX2_23144817_ChIP-Seq_PC3_Human1.30167396
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29931198
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29091180
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28067337
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27811696
98TP53_22573176_ChIP-Seq_HFKS_Human1.27273007
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25895017
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25595145
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24457751
102MAF_26560356_Chip-Seq_TH1_Human1.24324586
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23171024
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22346594
105E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21879507
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.21230876
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20720408
108RUNX_20019798_ChIP-Seq_JUKART_Human1.20276577
109MYB_26560356_Chip-Seq_TH1_Human1.19879912
110LXR_22158963_ChIP-Seq_LIVER_Mouse1.19471098
111GABP_19822575_ChIP-Seq_HepG2_Human1.19271915
112FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18525137
113NOTCH1_21737748_ChIP-Seq_TLL_Human1.17892066
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17449286
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16466617
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16069924
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14236484
118* TTF2_22483619_ChIP-Seq_HELA_Human1.13970862
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13503151
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12376373
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12281131
122E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11932864
123SOX2_16153702_ChIP-ChIP_HESCs_Human1.10823732
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10815876
125DCP1A_22483619_ChIP-Seq_HELA_Human1.10472509
126* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10000543
127THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09937969
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09511293
129STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09382879
130SPI1_23127762_ChIP-Seq_K562_Human1.07938301
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07715820
132MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07076320
133GATA2_21666600_ChIP-Seq_HMVEC_Human1.06133984
134PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04780436
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03556126
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02974252
137CBP_20019798_ChIP-Seq_JUKART_Human1.02974252
138EZH2_27294783_Chip-Seq_NPCs_Mouse1.02801492
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02396687
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01660104
141FOXO3_23340844_ChIP-Seq_DLD1_Human1.01382850
142SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00597764
143NFE2_27457419_Chip-Seq_LIVER_Mouse1.00207455
144MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99823334
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99557085
146FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99001476
147ER_23166858_ChIP-Seq_MCF-7_Human0.98981349
148* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98421155
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96986085
150GATA3_27048872_Chip-Seq_THYMUS_Human0.96719596
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96599620
152KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94838993
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94431478
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94191759
155NCOR1_26117541_ChIP-Seq_K562_Human0.93984796
156HTT_18923047_ChIP-ChIP_STHdh_Human0.93764745
157MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93745423
158FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93312928
159* SMAD4_21799915_ChIP-Seq_A2780_Human0.92958994
160CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92810751
161MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92331745
162NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91151565
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90801224
164SOX2_19829295_ChIP-Seq_ESCs_Human0.90738050
165NANOG_19829295_ChIP-Seq_ESCs_Human0.90738050
166NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90563029
167TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89819357
168ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89785883
169LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88900188
170KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88451839
171CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88366003
172SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87874611
173SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85512724
174ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85486753
175NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83887495
176NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82757853
177KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81275820
178WT1_19549856_ChIP-ChIP_CCG9911_Human0.81249742
179MYC_22102868_ChIP-Seq_BL_Human0.80999384
180KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80997964
181NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79598429
182LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79521034
183ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78797412
184KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77409130
185ELF1_20517297_ChIP-Seq_JURKAT_Human0.76665468
186NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74758744
187GATA3_26560356_Chip-Seq_TH2_Human0.74494238
188E2F1_17053090_ChIP-ChIP_MCF-7_Human0.74471390
189NANOG_18692474_ChIP-Seq_MESCs_Mouse0.73799258
190CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72852474
191VDR_21846776_ChIP-Seq_THP-1_Human0.72608141
192ELF1_17652178_ChIP-ChIP_JURKAT_Human0.72526208
193CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.72206795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.71878857
2MP0002822_catalepsy4.03793613
3MP0003011_delayed_dark_adaptation3.35990679
4MP0004264_abnormal_extraembryonic_tissu3.10532873
5MP0001835_abnormal_antigen_presentation2.98640939
6MP0003787_abnormal_imprinting2.79162237
7MP0003183_abnormal_peptide_metabolism2.77460290
8MP0005075_abnormal_melanosome_morpholog2.76634788
9MP0001529_abnormal_vocalization2.75680379
10MP0006082_CNS_inflammation2.73606831
11MP0000685_abnormal_immune_system2.57290755
12MP0001188_hyperpigmentation2.54384587
13MP0000372_irregular_coat_pigmentation2.49758400
14MP0002160_abnormal_reproductive_system2.48138180
15MP0002277_abnormal_respiratory_mucosa2.34490778
16MP0003315_abnormal_perineum_morphology2.27664594
17MP0006276_abnormal_autonomic_nervous2.26481421
18MP0006292_abnormal_olfactory_placode2.24820890
19MP0003436_decreased_susceptibility_to2.19401984
20MP0004858_abnormal_nervous_system2.18581146
21MP0009785_altered_susceptibility_to2.18348743
22MP0008058_abnormal_DNA_repair2.12640436
23MP0005394_taste/olfaction_phenotype2.12552381
24MP0005499_abnormal_olfactory_system2.12552381
25MP0001790_abnormal_immune_system2.12455769
26MP0005387_immune_system_phenotype2.12455769
27MP0002332_abnormal_exercise_endurance2.06358018
28MP0002138_abnormal_hepatobiliary_system2.04400229
29MP0005671_abnormal_response_to2.01984957
30MP0005645_abnormal_hypothalamus_physiol2.01552735
31MP0003880_abnormal_central_pattern2.00198778
32MP0005000_abnormal_immune_tolerance1.99021763
33MP0002396_abnormal_hematopoietic_system1.95712194
34MP0002148_abnormal_hypersensitivity_rea1.94525610
35MP0002877_abnormal_melanocyte_morpholog1.88674977
36MP0001800_abnormal_humoral_immune1.87469277
37MP0001348_abnormal_lacrimal_gland1.86745271
38MP0003123_paternal_imprinting1.82762616
39MP0002166_altered_tumor_susceptibility1.82046394
40MP0005646_abnormal_pituitary_gland1.80204029
41MP0002009_preneoplasia1.75033797
42MP0005025_abnormal_response_to1.72447333
43MP0006072_abnormal_retinal_apoptosis1.68807579
44MP0001542_abnormal_bone_strength1.66307812
45MP0003890_abnormal_embryonic-extraembry1.66076686
46MP0002233_abnormal_nose_morphology1.65771392
47MP0010094_abnormal_chromosome_stability1.64526234
48MP0003724_increased_susceptibility_to1.64303637
49MP0001293_anophthalmia1.61150169
50MP0004957_abnormal_blastocyst_morpholog1.60829852
51MP0002723_abnormal_immune_serum1.59735394
52MP0008057_abnormal_DNA_replication1.57464124
53MP0003077_abnormal_cell_cycle1.53852553
54MP0002938_white_spotting1.52670393
55MP0002452_abnormal_antigen_presenting1.51994413
56MP0003136_yellow_coat_color1.51416773
57MP0002163_abnormal_gland_morphology1.50778631
58MP0005360_urolithiasis1.50770794
59MP0003121_genomic_imprinting1.50088240
60MP0000778_abnormal_nervous_system1.49917951
61MP0003718_maternal_effect1.47340997
62MP0005365_abnormal_bile_salt1.46467676
63MP0004145_abnormal_muscle_electrophysio1.45734120
64MP0005253_abnormal_eye_physiology1.45367338
65MP0005310_abnormal_salivary_gland1.44499058
66MP0002006_tumorigenesis1.43742756
67MP0001819_abnormal_immune_cell1.43709664
68MP0002420_abnormal_adaptive_immunity1.42493947
69MP0002184_abnormal_innervation1.42234600
70MP0008877_abnormal_DNA_methylation1.42121154
71MP0005389_reproductive_system_phenotype1.41235456
72MP0003111_abnormal_nucleus_morphology1.41094858
73MP0000647_abnormal_sebaceous_gland1.40342391
74MP0005257_abnormal_intraocular_pressure1.40271706
75MP0009764_decreased_sensitivity_to1.39560753
76MP0001984_abnormal_olfaction1.39291469
77MP0000427_abnormal_hair_cycle1.38770318
78MP0006035_abnormal_mitochondrial_morpho1.37684209
79MP0002653_abnormal_ependyma_morphology1.37036702
80MP0002909_abnormal_adrenal_gland1.36668004
81MP0002139_abnormal_hepatobiliary_system1.34873474
82MP0001346_abnormal_lacrimal_gland1.33734095
83MP0010155_abnormal_intestine_physiology1.32711905
84MP0010352_gastrointestinal_tract_polyps1.32531237
85MP0004142_abnormal_muscle_tone1.29649025
86MP0002419_abnormal_innate_immunity1.29045471
87MP0008875_abnormal_xenobiotic_pharmacok1.27706602
88MP0002210_abnormal_sex_determination1.27257549
89MP0002102_abnormal_ear_morphology1.26357001
90MP0003937_abnormal_limbs/digits/tail_de1.25925414
91MP0003567_abnormal_fetal_cardiomyocyte1.25431206
92MP0003806_abnormal_nucleotide_metabolis1.25303264
93MP0008932_abnormal_embryonic_tissue1.25024964
94MP0000716_abnormal_immune_system1.24551740
95MP0000569_abnormal_digit_pigmentation1.23158200
96MP0002398_abnormal_bone_marrow1.21684896
97MP0004133_heterotaxia1.19473661
98MP0000631_abnormal_neuroendocrine_gland1.17656798
99MP0002234_abnormal_pharynx_morphology1.16823758
100MP0002405_respiratory_system_inflammati1.14745723
101MP0010030_abnormal_orbit_morphology1.13025039
102MP0008469_abnormal_protein_level1.11089405
103MP0000689_abnormal_spleen_morphology1.10559862
104MP0002722_abnormal_immune_system1.10468710
105MP0005187_abnormal_penis_morphology1.07784681
106MP0004782_abnormal_surfactant_physiolog1.07608311
107MP0002429_abnormal_blood_cell1.07394040
108MP0001145_abnormal_male_reproductive1.07368260
109MP0008995_early_reproductive_senescence1.06964358
110MP0001845_abnormal_inflammatory_respons1.03639946
111MP0005319_abnormal_enzyme/_coenzyme1.02170438
112MP0003786_premature_aging1.01803430
113MP0003186_abnormal_redox_activity1.01696092
114MP0000609_abnormal_liver_physiology1.01535782
115MP0002272_abnormal_nervous_system1.01253166
116MP0003303_peritoneal_inflammation1.01137306
117MP0002752_abnormal_somatic_nervous1.01112458
118MP0000653_abnormal_sex_gland1.00187459
119MP0005248_abnormal_Harderian_gland1.00041142
120MP0001286_abnormal_eye_development0.99679844
121MP0004381_abnormal_hair_follicle0.99593745
122MP0005379_endocrine/exocrine_gland_phen0.99537517
123MP0005085_abnormal_gallbladder_physiolo0.98397807
124MP0005367_renal/urinary_system_phenotyp0.98202444
125MP0000516_abnormal_urinary_system0.98202444
126MP0003191_abnormal_cellular_cholesterol0.98159332
127MP0002928_abnormal_bile_duct0.97523450
128MP0006036_abnormal_mitochondrial_physio0.97073825
129MP0005551_abnormal_eye_electrophysiolog0.95256507
130MP0003252_abnormal_bile_duct0.94471098
131MP0009697_abnormal_copulation0.93484277
132MP0002095_abnormal_skin_pigmentation0.93331709
133MP0008961_abnormal_basal_metabolism0.92993898
134MP0005266_abnormal_metabolism0.90966052
135MP0001929_abnormal_gametogenesis0.90680927
136MP0009840_abnormal_foam_cell0.89947389
137MP0000490_abnormal_crypts_of0.89097791
138MP0005464_abnormal_platelet_physiology0.88731880
139MP0001119_abnormal_female_reproductive0.88537081
140MP0003448_altered_tumor_morphology0.88348776
141MP0005391_vision/eye_phenotype0.88243707
142MP0008789_abnormal_olfactory_epithelium0.88061713
143MP0003119_abnormal_digestive_system0.87990124
144MP0004147_increased_porphyrin_level0.86606218
145MP0001853_heart_inflammation0.85797977
146MP0006054_spinal_hemorrhage0.85674472
147MP0002751_abnormal_autonomic_nervous0.84031199
148MP0009046_muscle_twitch0.83792708
149MP0005584_abnormal_enzyme/coenzyme_acti0.83569251
150MP0005084_abnormal_gallbladder_morpholo0.83229130
151MP0009763_increased_sensitivity_to0.83076584
152MP0002084_abnormal_developmental_patter0.82117322
153MP0008007_abnormal_cellular_replicative0.81762359
154MP0005195_abnormal_posterior_eye0.80681459
155MP0000383_abnormal_hair_follicle0.80335455
156MP0003861_abnormal_nervous_system0.79400141
157MP0000343_altered_response_to0.79128333
158MP0005397_hematopoietic_system_phenotyp0.78232550
159MP0001545_abnormal_hematopoietic_system0.78232550
160MP0010329_abnormal_lipoprotein_level0.77775835
161MP0009765_abnormal_xenobiotic_induced0.76262371
162MP0002882_abnormal_neuron_morphology0.76039598
163MP0003693_abnormal_embryo_hatching0.75925745
164MP0004134_abnormal_chest_morphology0.75666984
165MP0004510_myositis0.74563614
166MP0000598_abnormal_liver_morphology0.73869652
167MP0002837_dystrophic_cardiac_calcinosis0.73084511
168MP0003705_abnormal_hypodermis_morpholog0.72805574
169MP0003941_abnormal_skin_development0.72578274
170MP0002638_abnormal_pupillary_reflex0.72516091
171MP0004811_abnormal_neuron_physiology0.72438722
172MP0005423_abnormal_somatic_nervous0.72077108
173MP0002557_abnormal_social/conspecific_i0.71847629
174MP0005408_hypopigmentation0.71348076
175MP0000955_abnormal_spinal_cord0.70876593
176MP0004924_abnormal_behavior0.69819898
177MP0002127_abnormal_cardiovascular_syste0.68812412
178MP0009333_abnormal_splenocyte_physiolog0.67614820
179MP0000678_abnormal_parathyroid_gland0.67113279
180MP0002098_abnormal_vibrissa_morphology0.66800662
181MP0001533_abnormal_skeleton_physiology0.66142312
182MP0010678_abnormal_skin_adnexa0.64967525
183MP0001666_abnormal_nutrient_absorption0.63895757
184MP0004947_skin_inflammation0.63440281
185MP0005083_abnormal_biliary_tract0.62479916
186MP0001270_distended_abdomen0.61543329
187MP0010368_abnormal_lymphatic_system0.61391095

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)7.51659045
2Bilateral microphthalmos (HP:0007633)5.64650424
3Reduced antithrombin III activity (HP:0001976)4.37048455
4Hypochromic anemia (HP:0001931)4.33299006
5Hepatoblastoma (HP:0002884)3.64835784
6Pancreatic cysts (HP:0001737)3.49723422
7Increased hepatocellular lipid droplets (HP:0006565)3.47437044
8Hyperinsulinemic hypoglycemia (HP:0000825)3.37939061
9Multiple enchondromatosis (HP:0005701)3.33878345
10Elevated erythrocyte sedimentation rate (HP:0003565)3.33776084
11Myositis (HP:0100614)3.32870153
12Acute necrotizing encephalopathy (HP:0006965)3.31447374
13Adrenal hypoplasia (HP:0000835)3.23774338
14Lipid accumulation in hepatocytes (HP:0006561)3.12413990
15Orchitis (HP:0100796)3.10758979
16Medial flaring of the eyebrow (HP:0010747)3.09360570
17Abnormal mitochondria in muscle tissue (HP:0008316)3.06701041
18Mitochondrial inheritance (HP:0001427)2.97625260
19Nasal polyposis (HP:0100582)2.92185461
20Gingival bleeding (HP:0000225)2.91926121
21Colon cancer (HP:0003003)2.91739553
22Pancreatic fibrosis (HP:0100732)2.91190354
23Increased CSF lactate (HP:0002490)2.89843703
24Abnormality of the intrinsic pathway (HP:0010989)2.87821488
25Progressive macrocephaly (HP:0004481)2.87301507
26Abnormality of liposaccharide metabolism (HP:0010968)2.86389353
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.86389353
28Abnormality of glycolipid metabolism (HP:0010969)2.86389353
29Renal Fanconi syndrome (HP:0001994)2.84815953
30Recurrent bacterial skin infections (HP:0005406)2.84304299
31Hypoplasia of the uterus (HP:0000013)2.81336286
32Abnormality of midbrain morphology (HP:0002418)2.78872697
33Molar tooth sign on MRI (HP:0002419)2.78872697
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.77658722
35Hypoplasia of the fovea (HP:0007750)2.77658722
36Acute encephalopathy (HP:0006846)2.75567940
37Type I transferrin isoform profile (HP:0003642)2.70822004
38Abnormal hemoglobin (HP:0011902)2.70180470
39Abnormality of renal resorption (HP:0011038)2.67624149
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.67017054
41Ragged-red muscle fibers (HP:0003200)2.66052647
42Recurrent abscess formation (HP:0002722)2.65925576
43Gait imbalance (HP:0002141)2.63138780
44Aplastic anemia (HP:0001915)2.62960479
45Anomalous pulmonary venous return (HP:0010772)2.62726708
46Aplasia/hypoplasia of the uterus (HP:0008684)2.61094299
47Neoplasm of striated muscle (HP:0009728)2.61080201
48Congenital primary aphakia (HP:0007707)2.61054829
49Autoimmune thrombocytopenia (HP:0001973)2.60436245
50Abnormality of the nasal mucosa (HP:0000433)2.58977242
51Abnormality of the labia minora (HP:0012880)2.58656120
52Neoplasm of the adrenal cortex (HP:0100641)2.56710939
53Recurrent viral infections (HP:0004429)2.55085971
54Petechiae (HP:0000967)2.54983002
55Rhabdomyosarcoma (HP:0002859)2.54838402
56Rectal fistula (HP:0100590)2.54107584
57Rectovaginal fistula (HP:0000143)2.54107584
58Oligodactyly (hands) (HP:0001180)2.53531948
59Cortical dysplasia (HP:0002539)2.53344568
60Microcytic anemia (HP:0001935)2.52430264
61Bifid tongue (HP:0010297)2.51906141
62Vaginal fistula (HP:0004320)2.51733678
63Chronic otitis media (HP:0000389)2.49047309
64Villous atrophy (HP:0011473)2.45356525
65Abnormality of small intestinal villus morphology (HP:0011472)2.45356525
66Methylmalonic acidemia (HP:0002912)2.44775737
673-Methylglutaconic aciduria (HP:0003535)2.39188238
68Horizontal nystagmus (HP:0000666)2.37524614
69Ependymoma (HP:0002888)2.37043078
70Congenital stationary night blindness (HP:0007642)2.36482133
71Increased IgM level (HP:0003496)2.35401343
72Nephrogenic diabetes insipidus (HP:0009806)2.35310251
73Abnormal hair whorl (HP:0010721)2.34977940
74Nephronophthisis (HP:0000090)2.33616683
75Abnormality of the salivary glands (HP:0010286)2.33418200
76True hermaphroditism (HP:0010459)2.32535451
77Anencephaly (HP:0002323)2.29111572
78Intestinal fistula (HP:0100819)2.26362365
79Vasculitis (HP:0002633)2.25020435
80Testicular atrophy (HP:0000029)2.24319936
81Abnormal pancreas size (HP:0012094)2.23053037
82Amyloidosis (HP:0011034)2.22391149
83Increased serum ferritin (HP:0003281)2.21963381
84Abnormal biliary tract physiology (HP:0012439)2.21416428
85Bile duct proliferation (HP:0001408)2.21416428
86Chest pain (HP:0100749)2.20593933
87Intrahepatic cholestasis (HP:0001406)2.19421669
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.18966735
89Fused cervical vertebrae (HP:0002949)2.18849224
90Growth hormone deficiency (HP:0000824)2.18655554
91Micronodular cirrhosis (HP:0001413)2.18401439
92Increased intramyocellular lipid droplets (HP:0012240)2.18271066
93Partial duplication of thumb phalanx (HP:0009944)2.17890734
94Combined immunodeficiency (HP:0005387)2.17142930
95Sex reversal (HP:0012245)2.16999344
96Abnormal sex determination (HP:0012244)2.16999344
97Sensory axonal neuropathy (HP:0003390)2.15493342
98Neoplasm of the tracheobronchial system (HP:0100552)2.15158093
99Aplasia/Hypoplasia of the tongue (HP:0010295)2.13423335
100Skin nodule (HP:0200036)2.13392535
101Macroorchidism (HP:0000053)2.12645180
102Abnormality of the pulmonary veins (HP:0011718)2.11223729
103Recurrent gram-negative bacterial infections (HP:0005420)2.10307109
104Peritonitis (HP:0002586)2.10043054
105Pulmonary infiltrates (HP:0002113)2.09873862
106Abnormality of T cell physiology (HP:0011840)2.09461711
107Nephroblastoma (Wilms tumor) (HP:0002667)2.09366418
108Abnormal number of erythroid precursors (HP:0012131)2.08926719
109Exertional dyspnea (HP:0002875)2.08348207
110Hepatocellular necrosis (HP:0001404)2.08344244
111Sclerocornea (HP:0000647)2.07768102
112Abnormality of iron homeostasis (HP:0011031)2.06971075
113Rib fusion (HP:0000902)2.05661833
114Intestinal atresia (HP:0011100)2.04697448
115Volvulus (HP:0002580)2.04266137
116Increased serum lactate (HP:0002151)2.03032853
117Meckel diverticulum (HP:0002245)2.00910051
118Purpura (HP:0000979)2.00166418
119Large earlobe (HP:0009748)2.00008384
120Abnormality of the fovea (HP:0000493)1.96783562
121Eczematoid dermatitis (HP:0000976)1.96444101
122Male pseudohermaphroditism (HP:0000037)1.96406207
123Embryonal renal neoplasm (HP:0011794)1.96268060
124Encephalitis (HP:0002383)1.95716384
125Genital tract atresia (HP:0001827)1.95216080
126Myocardial infarction (HP:0001658)1.95155682
127Recurrent skin infections (HP:0001581)1.95019874
128Abnormality of chromosome stability (HP:0003220)1.94995101
129Vaginal atresia (HP:0000148)1.94899778
130Cellulitis (HP:0100658)1.93913936
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93871331
132Hepatic necrosis (HP:0002605)1.93620092
133Abnormal lung lobation (HP:0002101)1.93457131
134Xanthomatosis (HP:0000991)1.93445385
135Abnormal delayed hypersensitivity skin test (HP:0002963)1.93284682
136Aplasia/Hypoplasia of the macula (HP:0008059)1.93016013
137Cerebral edema (HP:0002181)1.92394785
138Abnormality of macrophages (HP:0004311)1.91744258
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91371091
140Supernumerary spleens (HP:0009799)1.90430082
141Dandy-Walker malformation (HP:0001305)1.90216757
142Abnormality of the ileum (HP:0001549)1.89329221
143Abnormality of cells of the erythroid lineage (HP:0012130)1.89069463
144Vacuolated lymphocytes (HP:0001922)1.88619361
145Chromsome breakage (HP:0040012)1.88490412
146Preaxial hand polydactyly (HP:0001177)1.88078521
147Abnormality of the renal medulla (HP:0100957)1.86884980
148Abnormality of transition element cation homeostasis (HP:0011030)1.86670178
149Postaxial hand polydactyly (HP:0001162)1.86473520
150Supernumerary nipples (HP:0002558)1.85472524
151Osteomalacia (HP:0002749)1.85349354
152Abnormality of the lower motor neuron (HP:0002366)1.85031697
153Abnormality of the prostate (HP:0008775)1.84891142
154Abnormal cartilage morphology (HP:0002763)1.84496611
155Abnormality of the corticospinal tract (HP:0002492)1.83941474
156Episodic fever (HP:0001954)1.83787816
157Poor coordination (HP:0002370)1.82205506
158Sloping forehead (HP:0000340)1.81834969
159Neoplasm of the adrenal gland (HP:0100631)1.81595504
160Lactic acidosis (HP:0003128)1.80943236
161Diastasis recti (HP:0001540)1.80387633
162Methylmalonic aciduria (HP:0012120)1.79761178
163Short 5th finger (HP:0009237)1.78889574
164Abnormality of the phalanges of the 5th finger (HP:0004213)1.78839304
165Concave nail (HP:0001598)1.78112583
166Multicystic kidney dysplasia (HP:0000003)1.77891508
167Joint hemorrhage (HP:0005261)1.77853893
168Agammaglobulinemia (HP:0004432)1.77546401
169Panhypogammaglobulinemia (HP:0003139)1.75900886
170Pendular nystagmus (HP:0012043)1.75468958
171Aganglionic megacolon (HP:0002251)1.75045093
172Amyotrophic lateral sclerosis (HP:0007354)1.75028981
173Duodenal stenosis (HP:0100867)1.73947216
174Small intestinal stenosis (HP:0012848)1.73947216
175Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73073929
176Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73073929
177Abnormal protein N-linked glycosylation (HP:0012347)1.72979074
178Abnormal protein glycosylation (HP:0012346)1.72979074
179Abnormal glycosylation (HP:0012345)1.72979074
180Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72979074
181Bony spicule pigmentary retinopathy (HP:0007737)1.72806454
182Atrophy/Degeneration involving motor neurons (HP:0007373)1.72089837
183Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71669797
184Astigmatism (HP:0000483)1.71226906
185Optic disc pallor (HP:0000543)1.71158073
186X-linked dominant inheritance (HP:0001423)1.67274993
187Abnormality of methionine metabolism (HP:0010901)1.66332252
188Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64964575
189Hypoplastic pelvis (HP:0008839)1.62114323
190Absent septum pellucidum (HP:0001331)1.62036095
191Renal cortical cysts (HP:0000803)1.61246460
192Abnormality of the duodenum (HP:0002246)1.61117150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.78653033
2GRK54.30038696
3ERN14.22729180
4BMPR1B3.82627211
5GRK63.68694206
6BUB13.60058241
7CSF1R3.21569565
8TGFBR23.11330620
9ADRBK23.02557531
10EIF2AK12.96017969
11MATK2.84748086
12MAP3K142.65919394
13MAP3K42.49424444
14GRK72.43007548
15TESK22.38989427
16GRK12.30725606
17SRPK12.25917465
18MAP2K72.23897868
19MUSK2.13957264
20STK102.13106429
21MAP4K22.09348645
22TYK22.07083365
23EIF2AK32.04423878
24ZAK1.90917844
25MOS1.90472077
26CDC71.84491600
27TIE11.83599069
28KIT1.82911205
29TAOK31.82687608
30NUAK11.79729774
31WNK31.77820623
32MINK11.77426013
33HIPK21.74529360
34DYRK31.72457922
35IKBKB1.66585276
36TRIM281.62562429
37CASK1.58641168
38VRK21.58224820
39MAPK71.57306754
40PLK31.55438858
41DYRK21.52898922
42FRK1.49089713
43MKNK11.43770285
44WNK11.40310381
45PLK21.34090174
46TAF11.33828373
47MAP3K131.33517594
48PLK11.32713751
49PRKG21.30264259
50MAP2K41.28921206
51JAK31.26368140
52TBK11.24123229
53CSK1.23155416
54NEK11.22879962
55PLK41.21157579
56STK391.19594519
57FGFR31.19316511
58CHUK1.18339941
59WNK41.17687153
60MKNK21.08677140
61PNCK1.07039193
62INSRR1.06735627
63MAP3K71.06501891
64CAMK41.06482960
65WEE11.05719578
66BRAF1.04784723
67CCNB11.04318191
68CSNK1G21.02549933
69NTRK11.02154377
70TYRO31.01338346
71TEC0.99285117
72CDK70.97382209
73FLT30.95440270
74CSNK1G10.94515638
75NME20.94165627
76VRK10.93704795
77MAP2K60.92323188
78ADRBK10.92011676
79CSNK1G30.91693089
80IKBKE0.90988086
81JAK20.88653022
82ITK0.86091301
83SYK0.85467908
84IRAK40.85273263
85PIM20.82504367
86BTK0.81427322
87TTK0.80451621
88PBK0.80445891
89PHKG20.80187909
90PHKG10.80187909
91JAK10.79899630
92MAP3K60.79800759
93PRKCG0.78132356
94MARK10.77680159
95RPS6KA40.77046516
96MARK20.76691992
97CDK190.75260738
98TNK20.74971252
99EIF2AK20.73025642
100OBSCN0.72712830
101CSNK1A1L0.72638918
102MST40.71834977
103LCK0.71228909
104MAP4K10.70382048
105ATR0.69435319
106ATM0.66695350
107ARAF0.65510309
108ACVR1B0.62337070
109BRSK20.62132706
110CSNK1E0.61864173
111IGF1R0.61172825
112BCR0.61109104
113TSSK60.58766940
114PRKAA20.56280499
115PAK30.56203784
116AURKB0.56160476
117PAK40.55962872
118MAPK40.55522747
119MST1R0.55204763
120AKT30.54500862
121MAPK120.53016943
122BRSK10.51031251
123PIM10.50496163
124AURKA0.49660239
125LYN0.49121130
126ZAP700.48104783
127PRKCQ0.47643321
128IRAK30.47325996
129BLK0.47195754
130MAP3K100.46655842
131SCYL20.46171156
132EGFR0.45213406
133DYRK1B0.44555619
134HCK0.44397770
135RAF10.43902964
136MAPK150.43699608
137OXSR10.43478948
138NTRK30.43388395
139TNIK0.43331560
140PRKCI0.43108008
141PDK20.42763320
142LMTK20.42747456
143PRKCE0.41638340
144SGK4940.41620166
145SGK2230.41620166
146SGK20.40979897
147NLK0.40571534
148CSNK2A10.39356141
149NME10.38997897
150ERBB40.38861047
151MAPKAPK20.38514902
152ABL10.38466514
153TGFBR10.38422168
154AKT20.38312408
155PIK3CG0.38194730
156RPS6KA20.37506081
157CSNK2A20.37129269
158LIMK10.37122983
159BRD40.36956719
160CHEK10.35829338
161IRAK10.35642744
162STK160.35401551
163* PRKCD0.34887512
164EPHB20.34793528
165ERBB30.34741433
166SIK30.34218637
167FGFR40.34110826
168FGFR10.32727052
169MAP3K120.30691680
170NEK90.29815852
171CDK60.29703203
172MAP2K30.29082215
173TXK0.28632134
174FES0.26294138
175STK40.26009902
176INSR0.25526725
177PRKAA10.23078468
178CHEK20.23068781
179MAPK110.22866639
180KSR20.22713481

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.14327011
2Vitamin B6 metabolism_Homo sapiens_hsa007503.52535187
3Oxidative phosphorylation_Homo sapiens_hsa001903.40289491
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.39217060
5Parkinsons disease_Homo sapiens_hsa050123.11604350
6Protein export_Homo sapiens_hsa030602.90431414
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.75303565
8Steroid biosynthesis_Homo sapiens_hsa001002.67256135
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.65840012
10Phototransduction_Homo sapiens_hsa047442.63697561
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.50023729
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.49016742
13Homologous recombination_Homo sapiens_hsa034402.46401942
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.43915427
15RNA polymerase_Homo sapiens_hsa030202.35478058
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27458716
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.25626215
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.22337252
19RNA degradation_Homo sapiens_hsa030182.13420850
20Huntingtons disease_Homo sapiens_hsa050162.12529147
21Leishmaniasis_Homo sapiens_hsa051402.11699615
22NF-kappa B signaling pathway_Homo sapiens_hsa040642.07302997
23Basal transcription factors_Homo sapiens_hsa030222.06987566
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02451043
25Fanconi anemia pathway_Homo sapiens_hsa034602.01561188
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.96871652
27Non-homologous end-joining_Homo sapiens_hsa034501.95382848
28Alzheimers disease_Homo sapiens_hsa050101.92678632
29Cardiac muscle contraction_Homo sapiens_hsa042601.91021969
30Mismatch repair_Homo sapiens_hsa034301.88307484
31RNA transport_Homo sapiens_hsa030131.86781727
32Other glycan degradation_Homo sapiens_hsa005111.85487566
33Allograft rejection_Homo sapiens_hsa053301.85341826
34Fatty acid elongation_Homo sapiens_hsa000621.80262031
35Fructose and mannose metabolism_Homo sapiens_hsa000511.78885514
36Complement and coagulation cascades_Homo sapiens_hsa046101.76913478
37Tryptophan metabolism_Homo sapiens_hsa003801.75447025
38B cell receptor signaling pathway_Homo sapiens_hsa046621.74809032
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73382415
40Base excision repair_Homo sapiens_hsa034101.70811172
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67698943
42Staphylococcus aureus infection_Homo sapiens_hsa051501.59862466
43Spliceosome_Homo sapiens_hsa030401.57742582
44Chemical carcinogenesis_Homo sapiens_hsa052041.55817646
45Arachidonic acid metabolism_Homo sapiens_hsa005901.53527038
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52173595
47Cell cycle_Homo sapiens_hsa041101.49182573
48Folate biosynthesis_Homo sapiens_hsa007901.48429927
49Primary immunodeficiency_Homo sapiens_hsa053401.46539974
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46475049
51DNA replication_Homo sapiens_hsa030301.44814464
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44480646
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43543898
54African trypanosomiasis_Homo sapiens_hsa051431.43498240
55Apoptosis_Homo sapiens_hsa042101.42355342
56Galactose metabolism_Homo sapiens_hsa000521.41055948
57Influenza A_Homo sapiens_hsa051641.37679421
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37591296
59Pertussis_Homo sapiens_hsa051331.35248424
60Herpes simplex infection_Homo sapiens_hsa051681.34666253
61Propanoate metabolism_Homo sapiens_hsa006401.31971269
62Acute myeloid leukemia_Homo sapiens_hsa052211.27933801
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27007990
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25728021
65TNF signaling pathway_Homo sapiens_hsa046681.23211354
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.23065280
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21737127
68Measles_Homo sapiens_hsa051621.20136491
69Sulfur relay system_Homo sapiens_hsa041221.19307605
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17454751
71Butanoate metabolism_Homo sapiens_hsa006501.14710282
72Toxoplasmosis_Homo sapiens_hsa051451.14569891
73Linoleic acid metabolism_Homo sapiens_hsa005911.13881146
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13056894
75Osteoclast differentiation_Homo sapiens_hsa043801.12063670
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10923070
77Thyroid cancer_Homo sapiens_hsa052161.09372195
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09078688
79Pyrimidine metabolism_Homo sapiens_hsa002401.08061974
80Hedgehog signaling pathway_Homo sapiens_hsa043401.07543907
81Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06790304
82Malaria_Homo sapiens_hsa051441.06565255
83Oocyte meiosis_Homo sapiens_hsa041141.06210305
84Caffeine metabolism_Homo sapiens_hsa002321.05648526
85Graft-versus-host disease_Homo sapiens_hsa053321.05156522
86Histidine metabolism_Homo sapiens_hsa003401.03897779
87Regulation of autophagy_Homo sapiens_hsa041401.02056032
88Hepatitis C_Homo sapiens_hsa051601.01434824
89Collecting duct acid secretion_Homo sapiens_hsa049660.98094649
90Hematopoietic cell lineage_Homo sapiens_hsa046400.97292188
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96430732
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95470250
93Peroxisome_Homo sapiens_hsa041460.94156366
94Ovarian steroidogenesis_Homo sapiens_hsa049130.94073301
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93824977
96Purine metabolism_Homo sapiens_hsa002300.92951381
97Tuberculosis_Homo sapiens_hsa051520.92820455
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.90287681
99Nucleotide excision repair_Homo sapiens_hsa034200.89960043
100ABC transporters_Homo sapiens_hsa020100.89134728
101Pyruvate metabolism_Homo sapiens_hsa006200.89008250
102Legionellosis_Homo sapiens_hsa051340.86053637
103Pancreatic cancer_Homo sapiens_hsa052120.84470564
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83459260
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82717203
106p53 signaling pathway_Homo sapiens_hsa041150.81169566
107Prolactin signaling pathway_Homo sapiens_hsa049170.75088984
108Metabolic pathways_Homo sapiens_hsa011000.74053019
109Starch and sucrose metabolism_Homo sapiens_hsa005000.73335922
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72817412
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72707159
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.72050049
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71112236
114T cell receptor signaling pathway_Homo sapiens_hsa046600.67217850
115Nicotine addiction_Homo sapiens_hsa050330.66475060
116Chemokine signaling pathway_Homo sapiens_hsa040620.65839133
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.65666007
118mRNA surveillance pathway_Homo sapiens_hsa030150.64669220
119Platelet activation_Homo sapiens_hsa046110.64241125
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61377204
121Shigellosis_Homo sapiens_hsa051310.61182783
122One carbon pool by folate_Homo sapiens_hsa006700.60942492
123Non-small cell lung cancer_Homo sapiens_hsa052230.59508701
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56887398
125Wnt signaling pathway_Homo sapiens_hsa043100.56081221
126Autoimmune thyroid disease_Homo sapiens_hsa053200.53413802
127Retinol metabolism_Homo sapiens_hsa008300.53400531
128Fatty acid metabolism_Homo sapiens_hsa012120.52158993
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52064499
130Type I diabetes mellitus_Homo sapiens_hsa049400.51368685
131Selenocompound metabolism_Homo sapiens_hsa004500.51092631
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51006597
133Long-term depression_Homo sapiens_hsa047300.50902919
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50092952
135Carbon metabolism_Homo sapiens_hsa012000.50013034
136Viral myocarditis_Homo sapiens_hsa054160.49576050
137mTOR signaling pathway_Homo sapiens_hsa041500.49064959
138Olfactory transduction_Homo sapiens_hsa047400.48540799
139Serotonergic synapse_Homo sapiens_hsa047260.47495799
140Axon guidance_Homo sapiens_hsa043600.47022198
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46867441
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.45846912
143Ether lipid metabolism_Homo sapiens_hsa005650.45501568
144Hepatitis B_Homo sapiens_hsa051610.45488907
145Biosynthesis of amino acids_Homo sapiens_hsa012300.44294853
146Inositol phosphate metabolism_Homo sapiens_hsa005620.43659343
147Dopaminergic synapse_Homo sapiens_hsa047280.42542442
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.42023739
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.41639027
150Glycosaminoglycan degradation_Homo sapiens_hsa005310.41320507
151Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40303007
152Ribosome_Homo sapiens_hsa030100.39210973
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39192342
154Viral carcinogenesis_Homo sapiens_hsa052030.37264286
155Arginine biosynthesis_Homo sapiens_hsa002200.36882131
156PPAR signaling pathway_Homo sapiens_hsa033200.36855433
157Chronic myeloid leukemia_Homo sapiens_hsa052200.36825105
158Circadian rhythm_Homo sapiens_hsa047100.36473483
159Antigen processing and presentation_Homo sapiens_hsa046120.36334614
160VEGF signaling pathway_Homo sapiens_hsa043700.36076154
161Pathways in cancer_Homo sapiens_hsa052000.35983080
162Rheumatoid arthritis_Homo sapiens_hsa053230.34261609
163Lysosome_Homo sapiens_hsa041420.33520533
164Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33514081
165Basal cell carcinoma_Homo sapiens_hsa052170.33179169
166Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30283086
167Glutathione metabolism_Homo sapiens_hsa004800.29319862
168Melanoma_Homo sapiens_hsa052180.27634247
169Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27622931
170Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26775546
171Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26582040
172Hippo signaling pathway_Homo sapiens_hsa043900.26263359
173Gap junction_Homo sapiens_hsa045400.25197682
174Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22899877
175Morphine addiction_Homo sapiens_hsa050320.21609716
176GABAergic synapse_Homo sapiens_hsa047270.21078644
177Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19943591
178Pentose phosphate pathway_Homo sapiens_hsa000300.19264772
179Colorectal cancer_Homo sapiens_hsa052100.18912519
180TGF-beta signaling pathway_Homo sapiens_hsa043500.18049117

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