EN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopaminergic neuron differentiation (GO:0071542)9.15256529
2dopamine biosynthetic process (GO:0042416)8.67765918
3dopamine transport (GO:0015872)6.93891743
4negative regulation of microtubule polymerization (GO:0031115)6.17743041
5regulation of catecholamine metabolic process (GO:0042069)5.56513814
6regulation of dopamine metabolic process (GO:0042053)5.56513814
7catechol-containing compound biosynthetic process (GO:0009713)5.32406026
8catecholamine biosynthetic process (GO:0042423)5.32406026
9alkaloid metabolic process (GO:0009820)5.31510293
10neuron cell-cell adhesion (GO:0007158)5.23363918
11catecholamine transport (GO:0051937)5.18546281
12response to insecticide (GO:0017085)4.80930075
13pyrimidine nucleobase catabolic process (GO:0006208)4.80767400
14* midbrain development (GO:0030901)4.76278976
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.76227356
16regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.52717766
17ATP synthesis coupled proton transport (GO:0015986)4.40504880
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40504880
19ribosomal small subunit biogenesis (GO:0042274)4.22451299
20lateral sprouting from an epithelium (GO:0060601)4.21833409
21lens morphogenesis in camera-type eye (GO:0002089)4.13421197
22layer formation in cerebral cortex (GO:0021819)4.05027266
23positive regulation of gastrulation (GO:2000543)3.94838355
24mating behavior (GO:0007617)3.79605039
25dendritic spine morphogenesis (GO:0060997)3.75301590
26establishment of tissue polarity (GO:0007164)3.63093206
27establishment of planar polarity (GO:0001736)3.63093206
28positive regulation of synapse assembly (GO:0051965)3.62618627
29cell proliferation involved in metanephros development (GO:0072203)3.62340464
30viral transcription (GO:0019083)3.61674717
31sequestering of actin monomers (GO:0042989)3.61178906
32thalamus development (GO:0021794)3.58572164
33phenol-containing compound biosynthetic process (GO:0046189)3.58477056
34nucleobase catabolic process (GO:0046113)3.56827393
35central nervous system projection neuron axonogenesis (GO:0021952)3.55334330
36primitive streak formation (GO:0090009)3.54927085
37dopamine metabolic process (GO:0042417)3.54591139
38vocalization behavior (GO:0071625)3.53116175
39opioid receptor signaling pathway (GO:0038003)3.52198849
40neuron maturation (GO:0042551)3.51704498
41cell migration in hindbrain (GO:0021535)3.50787066
42synaptic transmission, dopaminergic (GO:0001963)3.49344391
43innervation (GO:0060384)3.47113437
44prepulse inhibition (GO:0060134)3.43712018
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.40671153
46positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.40509388
47translational termination (GO:0006415)3.39014400
48phenol-containing compound catabolic process (GO:0019336)3.38923418
49regulation of axon guidance (GO:1902667)3.38850712
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.34194877
51regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31686814
52protein heterotrimerization (GO:0070208)3.30078001
53neuron recognition (GO:0008038)3.25900873
54negative regulation of axon extension (GO:0030517)3.25442911
55limb bud formation (GO:0060174)3.24144725
56kidney morphogenesis (GO:0060993)3.23937878
57monoamine transport (GO:0015844)3.22712241
58* hindbrain development (GO:0030902)3.20687563
59somite development (GO:0061053)3.19299304
60regulation of synapse structural plasticity (GO:0051823)3.18274568
61behavioral response to cocaine (GO:0048148)3.16053151
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15542505
63regulation of dopamine secretion (GO:0014059)3.14544326
64synaptic transmission, cholinergic (GO:0007271)3.09749478
65neuron remodeling (GO:0016322)3.08885235
66dendrite morphogenesis (GO:0048813)3.06366847
67regulation of synapse assembly (GO:0051963)3.05298398
68dorsal/ventral neural tube patterning (GO:0021904)3.04082204
69exploration behavior (GO:0035640)3.02128335
70positive regulation of response to oxidative stress (GO:1902884)3.01564074
71positive regulation of cellular response to oxidative stress (GO:1900409)3.01564074
72metanephric mesenchyme development (GO:0072075)3.01002469
73neuron fate specification (GO:0048665)3.00987133
74neuronal stem cell maintenance (GO:0097150)3.00021588
75heart valve formation (GO:0003188)2.99498556
76toxin metabolic process (GO:0009404)2.99330739
77regulation of respiratory gaseous exchange (GO:0043576)2.97281078
78regulation of axon extension involved in axon guidance (GO:0048841)2.96544044
79startle response (GO:0001964)2.96354893
80regulation of microtubule polymerization (GO:0031113)2.94269593
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93547010
82cochlea development (GO:0090102)2.93531818
83positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.92185847
84retinal ganglion cell axon guidance (GO:0031290)2.91611495
85lens fiber cell differentiation (GO:0070306)2.90879878
86neurotransmitter biosynthetic process (GO:0042136)2.90838609
87cranial nerve morphogenesis (GO:0021602)2.90488422
88cellular protein complex disassembly (GO:0043624)2.90214474
89mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88738386
90pattern specification involved in kidney development (GO:0061004)2.87534112
91camera-type eye morphogenesis (GO:0048593)2.87287900
92postsynaptic membrane organization (GO:0001941)2.85664443
93epithelial cell maturation (GO:0002070)2.85428514
94negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.85294031
95collagen fibril organization (GO:0030199)2.84697432
96axonal fasciculation (GO:0007413)2.84543502
97positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.83183157
98regulation of synaptic transmission, dopaminergic (GO:0032225)2.83059258
99peptidyl-arginine omega-N-methylation (GO:0035247)2.82339208
100cotranslational protein targeting to membrane (GO:0006613)2.79206477
101* response to cocaine (GO:0042220)2.78796211
102spinal cord development (GO:0021510)2.78633861
103neuron projection extension involved in neuron projection guidance (GO:1902284)2.77843924
104axon extension involved in axon guidance (GO:0048846)2.77843924
105peptidyl-arginine N-methylation (GO:0035246)2.77217047
106peptidyl-arginine methylation (GO:0018216)2.77217047
107cerebellar Purkinje cell layer development (GO:0021680)2.75632035
108negative regulation of neurotransmitter transport (GO:0051589)2.74608618
109mesenchymal-epithelial cell signaling (GO:0060638)2.74552856
110protein targeting to ER (GO:0045047)2.74002379
111regulation of respiratory system process (GO:0044065)2.73470448
112retina layer formation (GO:0010842)2.73247707
113planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73108905
114serotonin metabolic process (GO:0042428)2.73031028
115synapse assembly (GO:0007416)2.72578936
116synaptic vesicle exocytosis (GO:0016079)2.72187528
117SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.71815680
118positive regulation of smoothened signaling pathway (GO:0045880)2.71729707
119cochlea morphogenesis (GO:0090103)2.71523138
120negative regulation of axon guidance (GO:1902668)2.71457239
121axon extension (GO:0048675)2.71143479
122epithelial cell differentiation involved in kidney development (GO:0035850)2.70921104
123urinary tract smooth muscle contraction (GO:0014848)2.70505205
124positive regulation of embryonic development (GO:0040019)2.70453363
125neuronal action potential propagation (GO:0019227)2.70317315
126positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68859333
127kidney mesenchyme development (GO:0072074)2.68640804
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66791193
129establishment of mitochondrion localization (GO:0051654)2.66179420
130positive regulation of fatty acid beta-oxidation (GO:0032000)2.64206529
131microtubule depolymerization (GO:0007019)2.64130368
132cerebellar Purkinje cell differentiation (GO:0021702)2.63743568
133central nervous system neuron axonogenesis (GO:0021955)2.63366614
134negative regulation of axonogenesis (GO:0050771)2.63237180
135myotube differentiation (GO:0014902)2.63042841
136urogenital system development (GO:0001655)2.62986328
137cerebral cortex radially oriented cell migration (GO:0021799)2.61129850
138behavioral response to ethanol (GO:0048149)2.59635330
139regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56898813
140neuron projection extension (GO:1990138)2.56544734
141positive regulation of mesenchymal cell proliferation (GO:0002053)2.54156047
142ganglion development (GO:0061548)2.54152853
143cardiac right ventricle morphogenesis (GO:0003215)2.53373295
144establishment of monopolar cell polarity (GO:0061162)2.52582905
145establishment or maintenance of monopolar cell polarity (GO:0061339)2.52582905
146auditory behavior (GO:0031223)2.51634886
147regulation of mesenchymal cell proliferation (GO:0010464)2.50949616
148positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.50181853
149cell-cell junction maintenance (GO:0045217)2.48470783
150behavioral response to nicotine (GO:0035095)2.48422967
151somite rostral/caudal axis specification (GO:0032525)2.46843682
152glutamate receptor signaling pathway (GO:0007215)2.44554987
153positive regulation of neuroblast proliferation (GO:0002052)2.44277156
154calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43232095
155mitochondrion transport along microtubule (GO:0047497)2.43039210
156establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43039210
157response to auditory stimulus (GO:0010996)2.40995803
158neuroblast proliferation (GO:0007405)2.40269190
159actin-myosin filament sliding (GO:0033275)2.40216575
160muscle filament sliding (GO:0030049)2.40216575
161locomotory exploration behavior (GO:0035641)2.40000898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.87607105
2GBX2_23144817_ChIP-Seq_PC3_Human3.73394034
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.17086001
4* EZH2_27304074_Chip-Seq_ESCs_Mouse3.14111645
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11592369
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.03627415
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00655986
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90807670
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84358226
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83796288
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83796288
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.77430234
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70439641
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70413899
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69528282
16* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.66077598
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61268337
18* CBX2_27304074_Chip-Seq_ESCs_Mouse2.48069967
19* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.47955273
20VDR_22108803_ChIP-Seq_LS180_Human2.44827383
21ZNF274_21170338_ChIP-Seq_K562_Hela2.39024476
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32791501
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26973722
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.26295751
25STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24286880
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23141360
27* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.16084479
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12042482
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06452549
30* ERG_21242973_ChIP-ChIP_JURKAT_Human2.02582798
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01037680
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94178802
33TAF15_26573619_Chip-Seq_HEK293_Human1.93081661
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91039621
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87570081
36REST_21632747_ChIP-Seq_MESCs_Mouse1.81418048
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81383687
38* TP53_20018659_ChIP-ChIP_R1E_Mouse1.73533515
39RNF2_27304074_Chip-Seq_NSC_Mouse1.72231616
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.70638803
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68163664
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67150471
43AR_21572438_ChIP-Seq_LNCaP_Human1.65816413
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60712301
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.60127230
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59230902
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.57245489
48* RING1B_27294783_Chip-Seq_NPCs_Mouse1.56157634
49DROSHA_22980978_ChIP-Seq_HELA_Human1.53818656
50* RING1B_27294783_Chip-Seq_ESCs_Mouse1.53461180
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49199696
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.48417679
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46889743
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39749094
55P300_19829295_ChIP-Seq_ESCs_Human1.38105142
56IGF1R_20145208_ChIP-Seq_DFB_Human1.36891773
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.36475005
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35743563
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35743563
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35198968
61FUS_26573619_Chip-Seq_HEK293_Human1.35099370
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34807705
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34295871
64* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32138187
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30527068
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.20911718
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20503763
68OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18227685
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13233181
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13076598
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.11636193
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11622811
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11303069
74CTCF_27219007_Chip-Seq_Bcells_Human1.09880895
75* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07460725
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06211070
77AHR_22903824_ChIP-Seq_MCF-7_Human1.06062121
78SMAD4_21799915_ChIP-Seq_A2780_Human1.06021298
79* ISL1_27105846_Chip-Seq_CPCs_Mouse1.04799738
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.04153525
81TP53_18474530_ChIP-ChIP_U2OS_Human1.04048817
82ER_23166858_ChIP-Seq_MCF-7_Human1.03519730
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02855214
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01632759
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00978721
86* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00949594
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99363860
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98925098
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97546495
90WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97459425
91* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97047832
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.96235528
93BCAT_22108803_ChIP-Seq_LS180_Human0.95797747
94TP53_16413492_ChIP-PET_HCT116_Human0.95565086
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95449344
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95180731
97* RUNX2_22187159_ChIP-Seq_PCA_Human0.95176378
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94145691
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93747680
100* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93288696
101* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92342045
102JUN_21703547_ChIP-Seq_K562_Human0.92043951
103* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92039098
104AR_25329375_ChIP-Seq_VCAP_Human0.91724238
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90596495
106ZNF263_19887448_ChIP-Seq_K562_Human0.89971358
107* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89451229
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89285187
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89190753
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89073708
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86387288
112* EP300_21415370_ChIP-Seq_HL-1_Mouse0.85385077
113* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84246955
114POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.83965859
115SALL1_21062744_ChIP-ChIP_HESCs_Human0.83895691
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83394601
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82276621
118EWS_26573619_Chip-Seq_HEK293_Human0.82264363
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82019910
120RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81725350
121SOX9_26525672_Chip-Seq_HEART_Mouse0.80989594
122AR_19668381_ChIP-Seq_PC3_Human0.80821463
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.80594381
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79102038
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78860017
126* KDM2B_26808549_Chip-Seq_K562_Human0.78215631
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.77580991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.99961716
2* MP0001905_abnormal_dopamine_level3.75668806
3MP0009379_abnormal_foot_pigmentation3.70576667
4MP0006276_abnormal_autonomic_nervous3.50674916
5MP0003880_abnormal_central_pattern3.29922737
6MP0003122_maternal_imprinting2.81966398
7MP0001346_abnormal_lacrimal_gland2.65330618
8MP0001529_abnormal_vocalization2.53578823
9MP0004859_abnormal_synaptic_plasticity2.51439124
10MP0001188_hyperpigmentation2.45450818
11MP0002102_abnormal_ear_morphology2.39104153
12MP0005171_absent_coat_pigmentation2.35304579
13* MP0003635_abnormal_synaptic_transmissio2.23468176
14MP0002734_abnormal_mechanical_nocicepti2.18077408
15MP0005423_abnormal_somatic_nervous2.14776963
16MP0005503_abnormal_tendon_morphology2.14016439
17MP0002909_abnormal_adrenal_gland2.13735208
18MP0002735_abnormal_chemical_nociception2.06808490
19MP0002063_abnormal_learning/memory/cond2.05622048
20MP0002184_abnormal_innervation2.02550016
21* MP0002572_abnormal_emotion/affect_behav1.99617231
22MP0004270_analgesia1.96714734
23MP0008438_abnormal_cutaneous_collagen1.94910647
24MP0005409_darkened_coat_color1.92334488
25MP0001299_abnormal_eye_distance/1.91536308
26* MP0000778_abnormal_nervous_system1.84955136
27MP0002733_abnormal_thermal_nociception1.78400768
28MP0009745_abnormal_behavioral_response1.76207235
29MP0005623_abnormal_meninges_morphology1.73265715
30MP0002751_abnormal_autonomic_nervous1.70675491
31MP0002938_white_spotting1.69980582
32MP0001486_abnormal_startle_reflex1.69699445
33MP0003942_abnormal_urinary_system1.69368246
34MP0002064_seizures1.62266065
35MP0003938_abnormal_ear_development1.61314924
36MP0002282_abnormal_trachea_morphology1.60504365
37MP0001440_abnormal_grooming_behavior1.59500371
38MP0004133_heterotaxia1.56378200
39MP0000049_abnormal_middle_ear1.56311734
40MP0000751_myopathy1.53879211
41* MP0002067_abnormal_sensory_capabilities1.50426549
42MP0000538_abnormal_urinary_bladder1.49423207
43MP0009046_muscle_twitch1.46897152
44MP0002557_abnormal_social/conspecific_i1.44850234
45MP0009053_abnormal_anal_canal1.43909703
46MP0009250_abnormal_appendicular_skeleto1.42469448
47MP0003136_yellow_coat_color1.38801842
48* MP0004924_abnormal_behavior1.38587264
49* MP0005386_behavior/neurological_phenoty1.38587264
50MP0002249_abnormal_larynx_morphology1.38427068
51MP0003959_abnormal_lean_body1.35952123
52MP0002822_catalepsy1.33101120
53MP0001968_abnormal_touch/_nociception1.30979337
54MP0002272_abnormal_nervous_system1.27575883
55MP0003385_abnormal_body_wall1.26891003
56MP0002177_abnormal_outer_ear1.24810085
57MP0009780_abnormal_chondrocyte_physiolo1.24461902
58MP0003705_abnormal_hypodermis_morpholog1.24371819
59MP0005220_abnormal_exocrine_pancreas1.22218440
60MP0000579_abnormal_nail_morphology1.21110251
61MP0001970_abnormal_pain_threshold1.20883337
62* MP0004811_abnormal_neuron_physiology1.19904859
63MP0003279_aneurysm1.19545027
64MP0004885_abnormal_endolymph1.16063799
65MP0001879_abnormal_lymphatic_vessel1.14383386
66MP0000749_muscle_degeneration1.13154178
67MP0004142_abnormal_muscle_tone1.13021926
68* MP0003937_abnormal_limbs/digits/tail_de1.12397218
69MP0002882_abnormal_neuron_morphology1.09966332
70MP0004272_abnormal_basement_membrane1.09888972
71MP0000462_abnormal_digestive_system1.08921885
72MP0004742_abnormal_vestibular_system1.08286055
73MP0002152_abnormal_brain_morphology1.08189757
74MP0002653_abnormal_ependyma_morphology1.07300127
75* MP0002066_abnormal_motor_capabilities/c1.06992565
76MP0000026_abnormal_inner_ear1.06779987
77MP0003890_abnormal_embryonic-extraembry1.06121213
78MP0005645_abnormal_hypothalamus_physiol1.04821245
79MP0000762_abnormal_tongue_morphology1.04152672
80MP0003935_abnormal_craniofacial_develop1.02469786
81MP0003755_abnormal_palate_morphology1.02358566
82MP0001286_abnormal_eye_development1.01305399
83MP0010030_abnormal_orbit_morphology0.98817115
84MP0003121_genomic_imprinting0.98252290
85MP0000537_abnormal_urethra_morphology0.95709161
86MP0000955_abnormal_spinal_cord0.95699902
87MP0002234_abnormal_pharynx_morphology0.95564765
88MP0003861_abnormal_nervous_system0.95451172
89MP0002638_abnormal_pupillary_reflex0.95075924
90MP0000631_abnormal_neuroendocrine_gland0.93923701
91MP0000733_abnormal_muscle_development0.93578412
92MP0003646_muscle_fatigue0.93332354
93MP0005508_abnormal_skeleton_morphology0.92635903
94MP0005369_muscle_phenotype0.92395158
95MP0002837_dystrophic_cardiac_calcinosis0.92047436
96MP0005620_abnormal_muscle_contractility0.90052096
97MP0001501_abnormal_sleep_pattern0.89454645
98MP0004134_abnormal_chest_morphology0.87947989
99MP0002116_abnormal_craniofacial_bone0.87107455
100MP0005275_abnormal_skin_tensile0.86706761
101MP0003119_abnormal_digestive_system0.86423120
102MP0002081_perinatal_lethality0.83518262
103MP0002106_abnormal_muscle_physiology0.83322669
104MP0001958_emphysema0.83065828
105MP0002277_abnormal_respiratory_mucosa0.82371937
106MP0002139_abnormal_hepatobiliary_system0.82005743
107MP0001340_abnormal_eyelid_morphology0.81625602
108MP0005197_abnormal_uvea_morphology0.80871277
109MP0005187_abnormal_penis_morphology0.80480829
110MP0002697_abnormal_eye_size0.78491980
111MP0000534_abnormal_ureter_morphology0.77979873
112MP0004883_abnormal_blood_vessel0.77076120
113MP0003632_abnormal_nervous_system0.77023754
114MP0003115_abnormal_respiratory_system0.76459753
115* MP0002752_abnormal_somatic_nervous0.74577478
116MP0002233_abnormal_nose_morphology0.73952561
117MP0002932_abnormal_joint_morphology0.73734865
118MP0002108_abnormal_muscle_morphology0.72776114
119MP0001943_abnormal_respiration0.71660370
120MP0002736_abnormal_nociception_after0.71606478
121MP0006072_abnormal_retinal_apoptosis0.71339675
122MP0002069_abnormal_eating/drinking_beha0.71094834
123MP0004145_abnormal_muscle_electrophysio0.70682508
124MP0003283_abnormal_digestive_organ0.70650869

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)7.71162493
2Anterior segment dysgenesis (HP:0007700)4.17023691
3Type 1 muscle fiber predominance (HP:0003803)4.09554413
4Morphological abnormality of the middle ear (HP:0008609)4.05997027
5Hypothermia (HP:0002045)4.01667040
6Neonatal short-limb short stature (HP:0008921)4.00793161
7Hypoplastic ischia (HP:0003175)3.83955209
8Cerebral inclusion bodies (HP:0100314)3.67064854
9Visual hallucinations (HP:0002367)3.66253984
10Abnormality of the ischium (HP:0003174)3.62901557
11Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.54940567
12Chin dimple (HP:0010751)3.42726339
13Papilledema (HP:0001085)3.40790991
14Slender build (HP:0001533)3.40360305
15Abnormality of the parathyroid morphology (HP:0011766)3.34619239
16Aplasia of the musculature (HP:0100854)3.22368625
17Hip contracture (HP:0003273)3.15209043
18Acute lymphatic leukemia (HP:0006721)3.11574149
19Increased hepatocellular lipid droplets (HP:0006565)2.98157391
20Acute necrotizing encephalopathy (HP:0006965)2.95606827
21Abnormal pupillary function (HP:0007686)2.87282704
22Muscle fiber inclusion bodies (HP:0100299)2.77072067
23Hypoventilation (HP:0002791)2.73514374
24Concave nail (HP:0001598)2.72923092
25Myokymia (HP:0002411)2.72023676
26Limited hip movement (HP:0008800)2.69005549
27Abnormal number of incisors (HP:0011064)2.68816393
28Nemaline bodies (HP:0003798)2.67240723
29Progressive macrocephaly (HP:0004481)2.66455292
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.62410596
31Premature rupture of membranes (HP:0001788)2.61052696
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.60587036
33Sparse lateral eyebrow (HP:0005338)2.57111422
34Wrist flexion contracture (HP:0001239)2.54380030
35Hyperthyroidism (HP:0000836)2.50994663
36Pheochromocytoma (HP:0002666)2.48458508
37Atonic seizures (HP:0010819)2.46701909
38Focal motor seizures (HP:0011153)2.44103877
39Agitation (HP:0000713)2.43377538
40Atelectasis (HP:0100750)2.42865249
41Calcaneovalgus deformity (HP:0001848)2.42212319
42Protrusio acetabuli (HP:0003179)2.41089866
43Infantile muscular hypotonia (HP:0008947)2.39975950
44Abnormal mitochondria in muscle tissue (HP:0008316)2.39005753
45Lipid accumulation in hepatocytes (HP:0006561)2.38157043
46Deformed tarsal bones (HP:0008119)2.37685320
47Abnormality of the anterior chamber (HP:0000593)2.36318109
48Mildly elevated creatine phosphokinase (HP:0008180)2.33294516
49Vitreoretinal degeneration (HP:0000655)2.31998122
50Morphological abnormality of the pyramidal tract (HP:0002062)2.30871565
51Focal seizures (HP:0007359)2.30401578
52Aplasia/Hypoplasia of the brainstem (HP:0007362)2.29868694
53Hypoplasia of the brainstem (HP:0002365)2.29868694
54Neurofibrillary tangles (HP:0002185)2.27902599
55Renal Fanconi syndrome (HP:0001994)2.27042677
56Maternal diabetes (HP:0009800)2.26303548
57Round ear (HP:0100830)2.25942044
58Thin ribs (HP:0000883)2.25920204
59Mitochondrial inheritance (HP:0001427)2.25419211
60Atrophic scars (HP:0001075)2.22984081
61Abnormality of the pubic bones (HP:0003172)2.22246419
62Heterochromia iridis (HP:0001100)2.21347315
63Postural tremor (HP:0002174)2.21339397
64Acute encephalopathy (HP:0006846)2.20975832
65Reticulocytopenia (HP:0001896)2.20653974
66Absence seizures (HP:0002121)2.19761917
67Lower limb amyotrophy (HP:0007210)2.17709567
68Macrocytic anemia (HP:0001972)2.16286293
69Hypoparathyroidism (HP:0000829)2.15860615
70Progressive cerebellar ataxia (HP:0002073)2.15623653
71Arthropathy (HP:0003040)2.15279501
72Abnormality of the calcaneus (HP:0008364)2.14398680
73Venous insufficiency (HP:0005293)2.13247420
74Delayed gross motor development (HP:0002194)2.11217182
75Delusions (HP:0000746)2.11064699
76Irregular vertebral endplates (HP:0003301)2.11059163
77Shallow orbits (HP:0000586)2.10669891
78Mild short stature (HP:0003502)2.10467694
79Flat capital femoral epiphysis (HP:0003370)2.10458053
80Abnormality of secondary sexual hair (HP:0009888)2.10222562
81Abnormality of the axillary hair (HP:0100134)2.10222562
82Mesomelia (HP:0003027)2.06507415
83Absent phalangeal crease (HP:0006109)2.05873199
84Bronchomalacia (HP:0002780)2.03437999
85Pallor (HP:0000980)2.03055604
86Exotropia (HP:0000577)2.02754608
87Failure to thrive in infancy (HP:0001531)2.00303383
88Bladder diverticulum (HP:0000015)1.99560862
89Insidious onset (HP:0003587)1.98582325
90Termporal pattern (HP:0011008)1.98582325
91Supranuclear gaze palsy (HP:0000605)1.96901909
92Increased density of long bones (HP:0006392)1.96097995
93Abnormality of the vertebral endplates (HP:0005106)1.96018330
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95890315
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.95890315
96Obstructive sleep apnea (HP:0002870)1.95550136
97Cervical subluxation (HP:0003308)1.94994873
98Congenital, generalized hypertrichosis (HP:0004540)1.94155266
99Epileptic encephalopathy (HP:0200134)1.93983916
100Midline defect of the nose (HP:0004122)1.93618683
101Soft skin (HP:0000977)1.93397048
102Genu recurvatum (HP:0002816)1.93344706
103Vertebral clefting (HP:0008428)1.92513175
104Muscle hypertrophy of the lower extremities (HP:0008968)1.92198059
105Amblyopia (HP:0000646)1.90295221
106Anxiety (HP:0000739)1.89544129
107Distal lower limb amyotrophy (HP:0008944)1.89144600
108Mutism (HP:0002300)1.89110695
109Neuroendocrine neoplasm (HP:0100634)1.89011080
110Apathy (HP:0000741)1.88787244
111Ankle contracture (HP:0006466)1.88588174
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87014631
113Absent epiphyses (HP:0010577)1.87014631
114Fetal akinesia sequence (HP:0001989)1.86395196
115Broad-based gait (HP:0002136)1.85299548
116Buphthalmos (HP:0000557)1.84652486
117Abnormality of placental membranes (HP:0011409)1.84093244
118Amniotic constriction ring (HP:0009775)1.84093244
119Increased intramyocellular lipid droplets (HP:0012240)1.83959256
120Ulnar deviation of the wrist (HP:0003049)1.83140513
121Exostoses (HP:0100777)1.82104294
122Overgrowth (HP:0001548)1.82064838
123Torticollis (HP:0000473)1.82043408
124Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81555258
125Short 4th metacarpal (HP:0010044)1.81555258
126Septo-optic dysplasia (HP:0100842)1.80210877
127Bilateral microphthalmos (HP:0007633)1.80003818
128Choanal stenosis (HP:0000452)1.79728497
129Narrow nasal bridge (HP:0000446)1.79280040
130Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78290105
131Waddling gait (HP:0002515)1.77297334
132Irregular epiphyses (HP:0010582)1.76794263
133Persistence of primary teeth (HP:0006335)1.75795104
134Spinal rigidity (HP:0003306)1.75748569
135Follicular hyperkeratosis (HP:0007502)1.75458547
136Myelomeningocele (HP:0002475)1.74754091
137Generalized tonic-clonic seizures (HP:0002069)1.74576127
138Facial hemangioma (HP:0000329)1.74549452
139Drooling (HP:0002307)1.74414971
140Excessive salivation (HP:0003781)1.74414971
141Wide anterior fontanel (HP:0000260)1.73818221
142Nasal speech (HP:0001611)1.73724430
143Fatigable weakness (HP:0003473)1.73119614
144Abnormality of the neuromuscular junction (HP:0003398)1.73119614
145Exertional dyspnea (HP:0002875)1.73061954
146Anophthalmia (HP:0000528)1.72500828
147Febrile seizures (HP:0002373)1.72468961
148Abnormality of dentin (HP:0010299)1.72423711
149Rib fusion (HP:0000902)1.72289176
150Barrel-shaped chest (HP:0001552)1.72055560
151Joint stiffness (HP:0001387)1.71767422
152Limb-girdle muscle atrophy (HP:0003797)1.71250485
153Abnormality of the 4th metacarpal (HP:0010012)1.70975969
154Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70698054
155Down-sloping shoulders (HP:0200021)1.70588085
156Peritonitis (HP:0002586)1.70366298
157Calf muscle hypertrophy (HP:0008981)1.69353883
158Fragile skin (HP:0001030)1.68493999
159Abnormality of the calf musculature (HP:0001430)1.66514450
160Osteoarthritis (HP:0002758)1.66092905
161Biconcave vertebral bodies (HP:0004586)1.65366728
162Limb-girdle muscle weakness (HP:0003325)1.64951915
163Myotonia (HP:0002486)1.64256489
164Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.63724210
165Abnormality of femoral epiphyses (HP:0006499)1.63724210
166Increased variability in muscle fiber diameter (HP:0003557)1.62676506
167Bulbous nose (HP:0000414)1.62246402
168Sleep apnea (HP:0010535)1.60128560
169Abnormality of the proximal phalanges of the hand (HP:0009834)1.57215081
170Epiphyseal dysplasia (HP:0002656)1.56613292
171Abnormality of the epiphysis of the femoral head (HP:0010574)1.55786648
172Vertebral arch anomaly (HP:0008438)1.55253316
173Abnormality of the 2nd finger (HP:0004100)1.54353188
174Abnormal finger flexion creases (HP:0006143)1.54249408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.05875927
2MARK15.00814563
3MAPK133.23017370
4UHMK13.11321960
5SIK22.82802986
6CSNK1G32.82114242
7PNCK2.63148140
8PLK22.63043635
9CSNK1G22.42162634
10FGR2.33486571
11LATS22.31675166
12MUSK2.27298974
13CSNK1G12.26120053
14NTRK32.24919532
15NTRK22.16793862
16PAK62.02702169
17GRK52.00193715
18CASK1.97637329
19DYRK21.94887403
20MAPKAPK51.89239073
21OBSCN1.87052767
22GRK61.82072946
23MAP3K91.81705151
24NME11.77688213
25ERBB31.64854487
26WEE11.63414427
27EPHB21.50709355
28MINK11.49158799
29MAP3K121.40833511
30ADRBK11.39575116
31CSNK1A1L1.36891054
32BMPR1B1.30312934
33CDK181.24486972
34CDK151.24375196
35KSR11.24005819
36BCR1.20588742
37MAP2K71.17879243
38PTK2B1.17031861
39DDR21.16514673
40MAP3K41.16234315
41CDK11A1.13756828
42IRAK21.12350868
43CDK141.11276782
44DYRK1A1.09270823
45CDK51.09101243
46CAMK2B1.04528555
47MARK20.98710172
48STK390.98530004
49CAMK2A0.97317758
50TRIB30.93726492
51TYRO30.93174993
52TESK10.93150498
53PLK30.93104486
54MKNK20.92044592
55PHKG20.89523191
56PHKG10.89523191
57TLK10.89200335
58NEK20.87825849
59MOS0.87107183
60TNIK0.86444361
61IRAK30.84511234
62MAPK40.83671081
63DYRK1B0.83221156
64WNK40.83170492
65PAK30.81799409
66BUB10.81621803
67WNK30.80369630
68ROCK20.78707509
69PDGFRB0.77237569
70ROCK10.77106092
71PDGFRA0.76840950
72TAF10.75384657
73MAP3K100.74425746
74CDK30.72252412
75STK160.71735466
76SIK10.70709413
77PINK10.69707470
78MAP2K40.67659528
79RET0.67299544
80ERBB20.66320515
81CSNK1D0.65463976
82LATS10.65355735
83STK110.63111427
84MAP3K60.62270521
85ILK0.61743638
86TAOK10.61036402
87DYRK30.59862890
88GRK70.58741641
89PKN10.57248708
90NTRK10.57104280
91CDC42BPA0.56954619
92MAPK90.56617580
93PRKCG0.54249005
94CAMK2D0.52957384
95MKNK10.52862056
96CSNK1E0.52721755
97VRK10.52207868
98RPS6KA60.51701499
99MYLK0.50486173
100CHUK0.49682131
101SIK30.49525923
102SGK4940.48795725
103SGK2230.48795725
104PRKACA0.46410569
105FES0.46060207
106CSNK1A10.45248517
107TTN0.45172346
108ADRBK20.45006680
109ABL20.44768717
110ICK0.44730108
111PRKCI0.44593200
112GSK3A0.44540759
113PRKACB0.44517581
114PAK20.44421060
115FYN0.43770809
116PKN20.42488976
117RPS6KA20.41797530
118FGFR20.41631759
119PTK20.40080486
120PRKG10.40000132
121TGFBR10.39582144
122IRAK10.39536888
123CAMK10.39251255
124RPS6KC10.38614439
125RPS6KL10.38614439
126RPS6KA40.38203393
127CAMK1D0.38039597
128LIMK10.37529034
129SGK20.37306234
130SGK10.36668492
131CAMK40.36322764
132PRKCB0.35142283
133PRKCZ0.33513594
134CAMK2G0.32548116
135CAMK1G0.32498838
136DMPK0.32424331
137MAPK80.32267973
138ERBB40.31800207

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.87518577
2Parkinsons disease_Homo sapiens_hsa050123.63535172
3Cocaine addiction_Homo sapiens_hsa050303.62168559
4Oxidative phosphorylation_Homo sapiens_hsa001903.40957740
5Ribosome_Homo sapiens_hsa030103.36208933
6Alzheimers disease_Homo sapiens_hsa050102.68211049
7Amphetamine addiction_Homo sapiens_hsa050312.48726361
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47981716
9Cardiac muscle contraction_Homo sapiens_hsa042602.44195527
10Synaptic vesicle cycle_Homo sapiens_hsa047212.35369157
11Serotonergic synapse_Homo sapiens_hsa047262.24269093
12Dopaminergic synapse_Homo sapiens_hsa047282.13094874
13Huntingtons disease_Homo sapiens_hsa050162.07601308
14Axon guidance_Homo sapiens_hsa043601.94695721
15GABAergic synapse_Homo sapiens_hsa047271.94391834
16Dorso-ventral axis formation_Homo sapiens_hsa043201.89947322
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81108267
18Protein digestion and absorption_Homo sapiens_hsa049741.61662636
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61525195
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59744409
21Notch signaling pathway_Homo sapiens_hsa043301.54930854
22Hedgehog signaling pathway_Homo sapiens_hsa043401.50333314
23Glutamatergic synapse_Homo sapiens_hsa047241.50046325
24Gap junction_Homo sapiens_hsa045401.43601856
25Basal cell carcinoma_Homo sapiens_hsa052171.40747831
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.40057634
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38276222
28Cholinergic synapse_Homo sapiens_hsa047251.34961172
29Insulin secretion_Homo sapiens_hsa049111.32877860
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32483370
31Histidine metabolism_Homo sapiens_hsa003401.31140735
32Morphine addiction_Homo sapiens_hsa050321.30485352
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28554700
34Taste transduction_Homo sapiens_hsa047421.27616443
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23251467
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20245989
37Tyrosine metabolism_Homo sapiens_hsa003501.15784203
38Long-term depression_Homo sapiens_hsa047301.14209980
39Circadian entrainment_Homo sapiens_hsa047131.13730964
40Phenylalanine metabolism_Homo sapiens_hsa003601.12869502
41Vibrio cholerae infection_Homo sapiens_hsa051101.12328618
42Proteasome_Homo sapiens_hsa030501.11203885
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.10594661
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07862641
45Wnt signaling pathway_Homo sapiens_hsa043101.06311342
46Alcoholism_Homo sapiens_hsa050341.06132138
47Dilated cardiomyopathy_Homo sapiens_hsa054141.05045999
48Collecting duct acid secretion_Homo sapiens_hsa049661.00272466
49Phagosome_Homo sapiens_hsa041450.98310574
50Melanogenesis_Homo sapiens_hsa049160.97936492
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94722149
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94004744
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91580173
54Renin secretion_Homo sapiens_hsa049240.90823762
55Oxytocin signaling pathway_Homo sapiens_hsa049210.90740139
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85174498
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84324408
58Salivary secretion_Homo sapiens_hsa049700.82071339
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78641772
60Gastric acid secretion_Homo sapiens_hsa049710.77698181
61Long-term potentiation_Homo sapiens_hsa047200.77115338
62Calcium signaling pathway_Homo sapiens_hsa040200.75058223
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72848626
64Renal cell carcinoma_Homo sapiens_hsa052110.72267188
65Butanoate metabolism_Homo sapiens_hsa006500.72216211
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70673690
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66285170
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63451937
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63311791
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62897680
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61700337
72Linoleic acid metabolism_Homo sapiens_hsa005910.61693340
73ECM-receptor interaction_Homo sapiens_hsa045120.61135000
74GnRH signaling pathway_Homo sapiens_hsa049120.61010165
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.60711204
76Protein export_Homo sapiens_hsa030600.60525732
77Hippo signaling pathway_Homo sapiens_hsa043900.59799256
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59681378
79ErbB signaling pathway_Homo sapiens_hsa040120.59237698
80Olfactory transduction_Homo sapiens_hsa047400.58008040
81Rap1 signaling pathway_Homo sapiens_hsa040150.56886702
82Ovarian steroidogenesis_Homo sapiens_hsa049130.56752472
83Estrogen signaling pathway_Homo sapiens_hsa049150.56178148
84Circadian rhythm_Homo sapiens_hsa047100.55800193
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54745958
86Proteoglycans in cancer_Homo sapiens_hsa052050.54398967
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54200083
88RNA polymerase_Homo sapiens_hsa030200.51778185
89Nitrogen metabolism_Homo sapiens_hsa009100.51321406
90Glioma_Homo sapiens_hsa052140.49165964
91African trypanosomiasis_Homo sapiens_hsa051430.49069342
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.48688074
93Phototransduction_Homo sapiens_hsa047440.48442892
94VEGF signaling pathway_Homo sapiens_hsa043700.48414944
95Glucagon signaling pathway_Homo sapiens_hsa049220.46902555
96Type II diabetes mellitus_Homo sapiens_hsa049300.46616360
97Spliceosome_Homo sapiens_hsa030400.46615719
98Focal adhesion_Homo sapiens_hsa045100.45693576
99MicroRNAs in cancer_Homo sapiens_hsa052060.45440491
100MAPK signaling pathway_Homo sapiens_hsa040100.43666621
101TGF-beta signaling pathway_Homo sapiens_hsa043500.43459003
102Tryptophan metabolism_Homo sapiens_hsa003800.42671342
103Thyroid hormone synthesis_Homo sapiens_hsa049180.42212002
104Amoebiasis_Homo sapiens_hsa051460.41772260
105Melanoma_Homo sapiens_hsa052180.40054360
106Steroid biosynthesis_Homo sapiens_hsa001000.39683990
107AMPK signaling pathway_Homo sapiens_hsa041520.38491647
108Ras signaling pathway_Homo sapiens_hsa040140.36714219
109Prolactin signaling pathway_Homo sapiens_hsa049170.36113840
110Renin-angiotensin system_Homo sapiens_hsa046140.35618465
111Bladder cancer_Homo sapiens_hsa052190.35140074
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34484051
113Insulin signaling pathway_Homo sapiens_hsa049100.33665013
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32218729
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32012931
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31828138
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30994762
118cAMP signaling pathway_Homo sapiens_hsa040240.30635040
119Ether lipid metabolism_Homo sapiens_hsa005650.30217289
120Pathways in cancer_Homo sapiens_hsa052000.30121229
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29215304
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.24503281
123Colorectal cancer_Homo sapiens_hsa052100.24313999
124Tight junction_Homo sapiens_hsa045300.23148516
125Viral myocarditis_Homo sapiens_hsa054160.22893224

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