EMP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.85493820
2neutrophil activation involved in immune response (GO:0002283)4.81096569
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.29726744
4negative regulation of cell killing (GO:0031342)4.29726744
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23112680
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.23112680
7ribosomal small subunit assembly (GO:0000028)4.18071487
8immunoglobulin mediated immune response (GO:0016064)4.15318636
9response to peptidoglycan (GO:0032494)3.90710088
10Arp2/3 complex-mediated actin nucleation (GO:0034314)3.90466548
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.89590380
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.89590380
13modulation by symbiont of host immune response (GO:0052553)3.89590380
14positive regulation by symbiont of host defense response (GO:0052509)3.89590380
15modulation by symbiont of host defense response (GO:0052031)3.89590380
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.89590380
17antigen processing and presentation of endogenous antigen (GO:0019883)3.86938389
18positive regulation of gamma-delta T cell activation (GO:0046645)3.83295820
19response to interferon-beta (GO:0035456)3.82566842
20respiratory burst (GO:0045730)3.73013159
21response to interferon-alpha (GO:0035455)3.66810030
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.64035554
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54058384
24regulation of B cell receptor signaling pathway (GO:0050855)3.53680264
25regulation of interferon-beta biosynthetic process (GO:0045357)3.47046469
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43760335
27positive regulation of interferon-alpha production (GO:0032727)3.41186207
28B cell mediated immunity (GO:0019724)3.30871590
29positive regulation of B cell differentiation (GO:0045579)3.30547560
30negative regulation of phagocytosis (GO:0050765)3.30194368
31mast cell activation (GO:0045576)3.28142635
32type I interferon signaling pathway (GO:0060337)3.25901783
33cellular response to type I interferon (GO:0071357)3.25901783
34antigen processing and presentation via MHC class Ib (GO:0002475)3.24845719
35defense response to protozoan (GO:0042832)3.24507368
36response to type I interferon (GO:0034340)3.24397470
37regulation of interferon-alpha production (GO:0032647)3.24265360
38regulation of T cell tolerance induction (GO:0002664)3.21533126
39neutrophil activation (GO:0042119)3.19304105
40leukocyte aggregation (GO:0070486)3.15732938
41cellular response to interferon-beta (GO:0035458)3.15676366
42response to protozoan (GO:0001562)3.13021433
43myeloid cell activation involved in immune response (GO:0002275)3.12743826
44detection of other organism (GO:0098543)3.10585742
45myeloid dendritic cell activation (GO:0001773)3.10147758
46granulocyte activation (GO:0036230)3.07137228
47regulation of B cell differentiation (GO:0045577)3.06523242
48regulation of vitamin D biosynthetic process (GO:0060556)3.06277801
49lymphocyte chemotaxis (GO:0048247)3.05839476
50production of molecular mediator involved in inflammatory response (GO:0002532)3.02804573
51cellular response to zinc ion (GO:0071294)3.01928595
52interferon-gamma-mediated signaling pathway (GO:0060333)3.01379540
53regulation of gamma-delta T cell activation (GO:0046643)3.01252987
54negative regulation of nitric oxide biosynthetic process (GO:0045019)3.01178221
55detection of bacterium (GO:0016045)3.00021602
56macrophage activation involved in immune response (GO:0002281)2.97093841
57actin nucleation (GO:0045010)2.95022987
58regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94547871
59regulation of natural killer cell mediated immunity (GO:0002715)2.94547871
60viral transcription (GO:0019083)2.94346976
61positive regulation of antigen processing and presentation (GO:0002579)2.93922217
62pinocytosis (GO:0006907)2.90353988
63cellular extravasation (GO:0045123)2.87927657
64positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.86818687
65positive regulation of macrophage differentiation (GO:0045651)2.86467404
66positive thymic T cell selection (GO:0045059)2.86336443
67response to muramyl dipeptide (GO:0032495)2.85652386
68regulation of interleukin-2 biosynthetic process (GO:0045076)2.84727720
69positive regulation of natural killer cell differentiation (GO:0032825)2.84200718
70positive regulation of monocyte chemotaxis (GO:0090026)2.84173617
71regulation of tolerance induction (GO:0002643)2.83680349
72lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83439669
73negative regulation of cytokine production involved in immune response (GO:0002719)2.82107138
74DNA deamination (GO:0045006)2.81629863
75regulation of mononuclear cell migration (GO:0071675)2.80298714
76translational termination (GO:0006415)2.79413667
77negative regulation of myeloid cell apoptotic process (GO:0033033)2.78624564
78mature B cell differentiation involved in immune response (GO:0002313)2.77828803
79regulation of lymphocyte migration (GO:2000401)2.77787783
80regulation of antigen processing and presentation (GO:0002577)2.75904656
81myeloid dendritic cell differentiation (GO:0043011)2.75791102
82T cell migration (GO:0072678)2.74226944
83negative regulation of interleukin-12 production (GO:0032695)2.73489942
84regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.72992828
85detection of external biotic stimulus (GO:0098581)2.72647260
86negative regulation of erythrocyte differentiation (GO:0045647)2.71826207
87regulation of T cell mediated cytotoxicity (GO:0001914)2.71713970
88endosome to melanosome transport (GO:0035646)2.68700797
89endosome to pigment granule transport (GO:0043485)2.68700797
90positive regulation of chemokine biosynthetic process (GO:0045080)2.68566610
91positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67854641
92detection of molecule of bacterial origin (GO:0032490)2.66628126
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66245286
94positive regulation of interferon-beta production (GO:0032728)2.66033338
95definitive hemopoiesis (GO:0060216)2.66012318
96positive regulation of lymphocyte migration (GO:2000403)2.65185859
97positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64742960
98negative regulation of viral genome replication (GO:0045071)2.64590478
99SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64425063
100regulation of mast cell activation involved in immune response (GO:0033006)2.63909605
101platelet dense granule organization (GO:0060155)2.62484643
102regulation of gamma-delta T cell differentiation (GO:0045586)2.62065498
103regulation of chronic inflammatory response (GO:0002676)2.61875800
104regulation of mast cell activation (GO:0033003)2.61692340
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.61529718
106positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60623096
107negative T cell selection (GO:0043383)2.59805052
108positive regulation of mast cell activation (GO:0033005)2.59118975
109regulation of interleukin-12 biosynthetic process (GO:0045075)2.59066577
110regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59053721
111regulation of leukocyte mediated cytotoxicity (GO:0001910)2.58131872
112B cell receptor signaling pathway (GO:0050853)2.58071778
113leukocyte degranulation (GO:0043299)2.57811192
114positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.57770682
115response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57480566
116response to host immune response (GO:0052572)2.57480566
117myeloid leukocyte activation (GO:0002274)2.57372833
118negative regulation of leukocyte mediated immunity (GO:0002704)2.57302396
119regulation of chemokine biosynthetic process (GO:0045073)2.56221224
120dendritic cell differentiation (GO:0097028)2.55920871
121protein targeting to ER (GO:0045047)2.55856541
122regulation of mast cell degranulation (GO:0043304)2.55810601
123negative thymic T cell selection (GO:0045060)2.54831138
124cotranslational protein targeting to membrane (GO:0006613)2.54805535
125regulation of monocyte chemotaxis (GO:0090025)2.54584028
126cellular defense response (GO:0006968)2.54543670
127positive regulation of isotype switching (GO:0045830)2.54142749
128sequestering of actin monomers (GO:0042989)2.53376226
129NIK/NF-kappaB signaling (GO:0038061)2.53360770
130mature B cell differentiation (GO:0002335)2.53120912
131positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.52643367
132regulation of regulatory T cell differentiation (GO:0045589)2.52458098
133regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.51965229
134negative regulation of innate immune response (GO:0045824)2.48565050
135response to interleukin-15 (GO:0070672)2.48470470
136regulation of necroptotic process (GO:0060544)2.45946215
137ribosomal small subunit biogenesis (GO:0042274)2.45011436
138leukocyte cell-cell adhesion (GO:0007159)2.44858347
139antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43899225
140positive regulation of tumor necrosis factor production (GO:0032760)2.43537164
141response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.43480700
142response to host defenses (GO:0052200)2.43480700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.94584100
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.55865111
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.87408742
4E2F7_22180533_ChIP-Seq_HELA_Human3.86360573
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.46932311
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44627625
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04918264
8* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.95469476
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.89576085
10* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.86664737
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83619210
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.75699520
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75510899
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.71634994
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69335384
16SCL_19346495_ChIP-Seq_HPC-7_Human2.56464082
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54652932
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54376232
19* SPI1_23547873_ChIP-Seq_NB4_Human2.48473059
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45291261
21* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40444385
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.34573139
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13806089
24VDR_21846776_ChIP-Seq_THP-1_Human2.13475823
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09589728
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03130413
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02546587
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00877628
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98351960
30VDR_24763502_ChIP-Seq_THP-1_Human1.94837039
31* MYB_26560356_Chip-Seq_TH2_Human1.93954884
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.93509940
33MAF_26560356_Chip-Seq_TH1_Human1.87875254
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87036724
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86802763
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85130692
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.81547846
38* MYC_22102868_ChIP-Seq_BL_Human1.78529646
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76835270
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69781817
41MYB_26560356_Chip-Seq_TH1_Human1.65619249
42* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57458621
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57359447
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53589326
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.52908451
46LXR_22292898_ChIP-Seq_THP-1_Human1.52884318
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49576255
48* UTX_26944678_Chip-Seq_JUKART_Human1.49312676
49* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49281701
50RUNX_20019798_ChIP-Seq_JUKART_Human1.48876034
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.47660712
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46242111
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41956074
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.41219738
55PU_27001747_Chip-Seq_BMDM_Mouse1.40385821
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39657205
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39631994
58* SPI1_23127762_ChIP-Seq_K562_Human1.37363944
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36508611
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35870461
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35612513
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33471614
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33258411
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29944857
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.26633873
66BCL6_27268052_Chip-Seq_Bcells_Human1.26275172
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.26148386
68VDR_23849224_ChIP-Seq_CD4+_Human1.25992806
69ELK1_19687146_ChIP-ChIP_HELA_Human1.24008368
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23200474
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.21461943
72GATA1_22025678_ChIP-Seq_K562_Human1.21252396
73VDR_24787735_ChIP-Seq_THP-1_Human1.21204094
74TFEB_21752829_ChIP-Seq_HELA_Human1.20539330
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.19351704
76MAF_26560356_Chip-Seq_TH2_Human1.18270693
77* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18197543
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18098735
79* TCF7_22412390_ChIP-Seq_EML_Mouse1.16968614
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16292309
81* KDM2B_26808549_Chip-Seq_DND41_Human1.16176339
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15546183
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.13810711
84BCOR_27268052_Chip-Seq_Bcells_Human1.13451579
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13182809
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.12888685
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11715268
88GATA1_19941826_ChIP-Seq_K562_Human1.11605530
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10111443
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09646091
91* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09420538
92* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09087637
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.08245191
94* NCOR1_26117541_ChIP-Seq_K562_Human1.07946630
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07099684
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06540969
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06328656
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05824940
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05808438
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.03176950
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02955382
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02901379
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01312157
104JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98779714
105* GATA3_27048872_Chip-Seq_THYMUS_Human0.98622927
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98188341
107* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98126391
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98097598
109FOXP3_21729870_ChIP-Seq_TREG_Human0.97795167
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96119793
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96008740
112GATA3_26560356_Chip-Seq_TH2_Human0.95583008
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94848908
114DCP1A_22483619_ChIP-Seq_HELA_Human0.94122543
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93409632
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93402474
117* ETS1_20019798_ChIP-Seq_JURKAT_Human0.92934850
118XRN2_22483619_ChIP-Seq_HELA_Human0.91880898
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90788083
120* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89447771
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88351701
122* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88266982
123* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88221420
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87531942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.19172908
2MP0003436_decreased_susceptibility_to3.46335882
3MP0009785_altered_susceptibility_to3.24873357
4MP0002148_abnormal_hypersensitivity_rea3.01297407
5MP0000685_abnormal_immune_system2.81579604
6MP0002419_abnormal_innate_immunity2.79660892
7MP0005000_abnormal_immune_tolerance2.76931146
8MP0005025_abnormal_response_to2.68705223
9MP0005671_abnormal_response_to2.66526946
10MP0003724_increased_susceptibility_to2.53557666
11MP0002452_abnormal_antigen_presenting2.52627057
12MP0001800_abnormal_humoral_immune2.41538337
13MP0005387_immune_system_phenotype2.39351744
14MP0001790_abnormal_immune_system2.39351744
15MP0002723_abnormal_immune_serum2.32938090
16MP0002420_abnormal_adaptive_immunity2.29104684
17MP0001819_abnormal_immune_cell2.28623884
18MP0003303_peritoneal_inflammation2.28436233
19MP0005464_abnormal_platelet_physiology2.24280122
20MP0002396_abnormal_hematopoietic_system2.21123862
21MP0006082_CNS_inflammation2.20671301
22MP0008438_abnormal_cutaneous_collagen2.19369011
23MP0005058_abnormal_lysosome_morphology2.09521873
24MP0001533_abnormal_skeleton_physiology2.05768821
25MP0009333_abnormal_splenocyte_physiolog2.04440315
26MP0002405_respiratory_system_inflammati2.01757046
27MP0005397_hematopoietic_system_phenotyp2.00452663
28MP0001545_abnormal_hematopoietic_system2.00452663
29MP0002166_altered_tumor_susceptibility1.97039434
30MP0002398_abnormal_bone_marrow1.95726773
31MP0001853_heart_inflammation1.95383812
32MP0000716_abnormal_immune_system1.82253618
33MP0004808_abnormal_hematopoietic_stem1.79976125
34MP0002006_tumorigenesis1.78389957
35MP0003763_abnormal_thymus_physiology1.75992900
36MP0000343_altered_response_to1.75594084
37MP0010155_abnormal_intestine_physiology1.72427574
38MP0001845_abnormal_inflammatory_respons1.71847248
39MP0000689_abnormal_spleen_morphology1.69438138
40MP0002933_joint_inflammation1.67875344
41MP0000858_altered_metastatic_potential1.66025122
42MP0003279_aneurysm1.62647541
43MP0006054_spinal_hemorrhage1.62488982
44MP0002722_abnormal_immune_system1.62079804
45MP0002429_abnormal_blood_cell1.60317306
46MP0005451_abnormal_body_composition1.59594843
47MP0004510_myositis1.55859036
48MP0000465_gastrointestinal_hemorrhage1.55648384
49MP0003806_abnormal_nucleotide_metabolis1.55186255
50MP0003448_altered_tumor_morphology1.55057627
51MP0000490_abnormal_crypts_of1.53604058
52MP0009278_abnormal_bone_marrow1.49361492
53MP0004947_skin_inflammation1.46792298
54MP0008469_abnormal_protein_level1.41700723
55MP0005174_abnormal_tail_pigmentation1.41407060
56MP0001873_stomach_inflammation1.39976610
57MP0000604_amyloidosis1.39604705
58MP0002998_abnormal_bone_remodeling1.31649491
59MP0008260_abnormal_autophagy1.30915627
60MP0003172_abnormal_lysosome_physiology1.28522040
61MP0005390_skeleton_phenotype1.27609885
62MP0009764_decreased_sensitivity_to1.25733437
63MP0003300_gastrointestinal_ulcer1.20079623
64MP0001958_emphysema1.16789576
65MP0000703_abnormal_thymus_morphology1.15132596
66MP0005023_abnormal_wound_healing1.13197999
67MP0005503_abnormal_tendon_morphology1.12756583
68MP0003828_pulmonary_edema1.06054999
69MP0003186_abnormal_redox_activity1.04682444
70MP0003566_abnormal_cell_adhesion1.04599207
71MP0005165_increased_susceptibility_to1.03869506
72MP0010352_gastrointestinal_tract_polyps1.02688360
73MP0003075_altered_response_to1.02130888
74MP0010307_abnormal_tumor_latency1.01804580
75MP0008007_abnormal_cellular_replicative0.98646435
76MP0003795_abnormal_bone_structure0.93715977
77MP0002019_abnormal_tumor_incidence0.93187190
78MP0004883_abnormal_blood_vessel0.91425084
79MP0003866_abnormal_defecation0.89792568
80MP0003656_abnormal_erythrocyte_physiolo0.89562099
81MP0005275_abnormal_skin_tensile0.89523294
82MP0001851_eye_inflammation0.89352552
83MP0005310_abnormal_salivary_gland0.88670521
84MP0001542_abnormal_bone_strength0.88335250
85MP0008004_abnormal_stomach_pH0.87545522
86MP0005166_decreased_susceptibility_to0.83646312
87MP0002132_abnormal_respiratory_system0.83410503
88MP0003693_abnormal_embryo_hatching0.81612866
89MP0009763_increased_sensitivity_to0.81462299
90MP0003453_abnormal_keratinocyte_physiol0.80697270
91MP0005164_abnormal_response_to0.79194557
92MP0000249_abnormal_blood_vessel0.77883944
93MP0000767_abnormal_smooth_muscle0.77629232
94MP0003950_abnormal_plasma_membrane0.76769419
95MP0002332_abnormal_exercise_endurance0.74729452
96MP0005257_abnormal_intraocular_pressure0.73696380
97MP0002095_abnormal_skin_pigmentation0.72479603
98MP0000015_abnormal_ear_pigmentation0.72365163
99MP0002254_reproductive_system_inflammat0.71052787
100MP0001243_abnormal_dermal_layer0.70462298
101MP0003191_abnormal_cellular_cholesterol0.69889350
102MP0003329_amyloid_beta_deposits0.69806917
103MP0005075_abnormal_melanosome_morpholog0.68700896
104MP0001663_abnormal_digestive_system0.67488589
105MP0003091_abnormal_cell_migration0.66747818
106MP0003705_abnormal_hypodermis_morpholog0.66744047
107MP0002877_abnormal_melanocyte_morpholog0.64941439
108MP0003045_fibrosis0.64478680
109MP0003077_abnormal_cell_cycle0.64216845
110MP0009840_abnormal_foam_cell0.60033866
111MP0009765_abnormal_xenobiotic_induced0.59960382
112MP0000313_abnormal_cell_death0.59538106
113MP0001879_abnormal_lymphatic_vessel0.59015477
114MP0000372_irregular_coat_pigmentation0.58522145
115MP0000920_abnormal_myelination0.58383090
116MP0003690_abnormal_glial_cell0.57317027
117MP0002113_abnormal_skeleton_development0.56107096

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.88923215
2Recurrent bacterial skin infections (HP:0005406)5.14103142
3Eczematoid dermatitis (HP:0000976)5.03004147
4Elevated erythrocyte sedimentation rate (HP:0003565)4.82515446
5Myositis (HP:0100614)4.27255168
6Recurrent gram-negative bacterial infections (HP:0005420)3.76269321
7Vacuolated lymphocytes (HP:0001922)3.71743185
8Abnormality of macrophages (HP:0004311)3.67541198
9Petechiae (HP:0000967)3.60877385
10Thrombocytosis (HP:0001894)3.58147322
11Mediastinal lymphadenopathy (HP:0100721)3.56760169
12Recurrent skin infections (HP:0001581)3.29157905
13Chronic otitis media (HP:0000389)3.27254229
14Cellulitis (HP:0100658)3.24226207
15Increased IgM level (HP:0003496)3.23303007
16Chronic obstructive pulmonary disease (HP:0006510)3.18876219
17Obstructive lung disease (HP:0006536)3.18876219
18Orchitis (HP:0100796)3.15025969
19T lymphocytopenia (HP:0005403)3.14804251
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.14362451
21Increased cerebral lipofuscin (HP:0011813)3.14258980
22Recurrent fungal infections (HP:0002841)3.10280601
23Systemic lupus erythematosus (HP:0002725)3.09682568
24Vertebral compression fractures (HP:0002953)3.07339920
25Recurrent viral infections (HP:0004429)3.02946874
26IgM deficiency (HP:0002850)2.99679195
27Abnormality of T cell number (HP:0011839)2.93453285
28Amyloidosis (HP:0011034)2.87523420
29Increased serum ferritin (HP:0003281)2.84743244
30Hepatosplenomegaly (HP:0001433)2.80582667
31Gingivitis (HP:0000230)2.68714295
32Meningitis (HP:0001287)2.65550453
33Basal ganglia calcification (HP:0002135)2.64122300
34Optic neuritis (HP:0100653)2.63938899
35Retrobulbar optic neuritis (HP:0100654)2.63938899
36Pustule (HP:0200039)2.62940569
37Autoimmune thrombocytopenia (HP:0001973)2.58491690
38Prolonged bleeding time (HP:0003010)2.57298729
39Abnormality of cells of the erythroid lineage (HP:0012130)2.56657726
40Abnormal number of erythroid precursors (HP:0012131)2.56055662
41Encephalitis (HP:0002383)2.53736477
42Gastrointestinal infarctions (HP:0005244)2.53534245
43Spontaneous hematomas (HP:0007420)2.53213554
44Vasculitis (HP:0002633)2.51458150
45Protrusio acetabuli (HP:0003179)2.51367086
46Recurrent bronchitis (HP:0002837)2.50659374
47Interstitial pulmonary disease (HP:0006530)2.48137031
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44536107
49Abnormality of polysaccharide metabolism (HP:0011012)2.44536107
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44536107
51Stomatitis (HP:0010280)2.43223071
52Poor head control (HP:0002421)2.42266785
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41650049
54Autoimmune hemolytic anemia (HP:0001890)2.41302887
55Beaking of vertebral bodies (HP:0004568)2.38618464
56Dysostosis multiplex (HP:0000943)2.35325631
57Nasal polyposis (HP:0100582)2.34758593
58Recurrent cutaneous fungal infections (HP:0011370)2.33933894
59Chronic mucocutaneous candidiasis (HP:0002728)2.33933894
60Episodic fever (HP:0001954)2.32763287
61Abnormality of the nasal mucosa (HP:0000433)2.32129739
62Reticulocytopenia (HP:0001896)2.31668110
63Cervical subluxation (HP:0003308)2.31560395
64Recurrent pneumonia (HP:0006532)2.31467697
65Purpura (HP:0000979)2.30019812
66Abnormality of iron homeostasis (HP:0011031)2.29728875
67Epistaxis (HP:0000421)2.29542818
68Aplastic anemia (HP:0001915)2.28907823
69Hypertensive crisis (HP:0100735)2.28761422
70Recurrent lower respiratory tract infections (HP:0002783)2.27360610
71Keratoconjunctivitis sicca (HP:0001097)2.26586685
72Abnormality of T cell physiology (HP:0011840)2.24406610
73Osteolytic defects of the hand bones (HP:0009699)2.24331797
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.24331797
75Chest pain (HP:0100749)2.22211993
76Myocardial infarction (HP:0001658)2.21020600
77Leukocytosis (HP:0001974)2.20116535
78Peritonitis (HP:0002586)2.17659686
79Reduced antithrombin III activity (HP:0001976)2.17632620
80Disinhibition (HP:0000734)2.17419768
81Urticaria (HP:0001025)2.17197941
82Periodontitis (HP:0000704)2.17178268
83Granulocytopenia (HP:0001913)2.15937536
84Progressive neurologic deterioration (HP:0002344)2.13943831
85Glomerulopathy (HP:0100820)2.13348296
86Pulmonary infiltrates (HP:0002113)2.12822033
87IgG deficiency (HP:0004315)2.11030457
88Abnormality of the prostate (HP:0008775)2.10974210
89Abnormality of T cells (HP:0002843)2.10837673
90Keratoconjunctivitis (HP:0001096)2.10430282
91Osteomyelitis (HP:0002754)2.09981048
92Increased IgE level (HP:0003212)2.07187117
93Hypergammaglobulinemia (HP:0010702)2.07164983
94Joint stiffness (HP:0001387)2.04873894
95Spondylolisthesis (HP:0003302)2.03819911
96Agnosia (HP:0010524)2.02317430
97Urinary glycosaminoglycan excretion (HP:0003541)2.02124581
98Mucopolysacchariduria (HP:0008155)2.02124581
99Biconcave vertebral bodies (HP:0004586)2.00913455
100Axonal loss (HP:0003447)2.00871455
101Abnormal delayed hypersensitivity skin test (HP:0002963)1.99046102
102Abnormality of the pericardium (HP:0001697)1.98799596
103Arterial thrombosis (HP:0004420)1.96654771
104Lymphopenia (HP:0001888)1.95978995
105Glomerulonephritis (HP:0000099)1.94104095
106Abnormality of cells of the lymphoid lineage (HP:0012140)1.94042898
107Spinal cord lesions (HP:0100561)1.93912269
108Syringomyelia (HP:0003396)1.93912269
109Abnormality of glycolipid metabolism (HP:0010969)1.93197538
110Abnormality of liposaccharide metabolism (HP:0010968)1.93197538
111Abnormality of glycosphingolipid metabolism (HP:0004343)1.93197538
112Abnormal platelet function (HP:0011869)1.90461390
113Impaired platelet aggregation (HP:0003540)1.90461390
114Panhypogammaglobulinemia (HP:0003139)1.90247743
115Abnormality of the lumbar spine (HP:0100712)1.89605090
116Gingival bleeding (HP:0000225)1.89551459
117Prostate neoplasm (HP:0100787)1.89522070
118Pallor (HP:0000980)1.87639325
119Hemoptysis (HP:0002105)1.86753268
120Arthralgia (HP:0002829)1.86403539
121Anorexia (HP:0002039)1.85601195
122Gangrene (HP:0100758)1.85394918
123Acrocyanosis (HP:0001063)1.85282969
124Skin ulcer (HP:0200042)1.84835430
125Thoracic kyphosis (HP:0002942)1.84371650
126Polyneuropathy (HP:0001271)1.83092364
127Dilatation of the ascending aorta (HP:0005111)1.83035229
128Agammaglobulinemia (HP:0004432)1.82982774
129Type I transferrin isoform profile (HP:0003642)1.82275699
130Premature rupture of membranes (HP:0001788)1.81925962
131Eosinophilia (HP:0001880)1.81738119
132Fatigue (HP:0012378)1.81494649
133Loss of speech (HP:0002371)1.81487874
134Hypertriglyceridemia (HP:0002155)1.79602409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.07680023
2MAP4K13.30612297
3KIT3.23328011
4PIM22.99788610
5BLK2.87554266
6TBK12.77672152
7IRAK42.69900475
8MAP3K142.39923021
9TXK2.26084046
10TYK22.22070539
11JAK32.20099715
12ERN12.11629335
13IKBKE2.06964939
14PRPF4B2.06024225
15TEC2.01775686
16BTK1.94456122
17GRK71.88229435
18ZAP701.86069656
19IKBKB1.80841743
20RIPK41.77540098
21MAP2K31.74860990
22CSF1R1.70078400
23IRAK31.65179407
24RPS6KA41.64571388
25TGFBR21.48839943
26LIMK11.48596287
27SYK1.44329717
28KDR1.44047414
29PIM11.39125478
30LRRK21.37164508
31FLT31.35017038
32BMPR21.31264192
33TRIB31.23026683
34STK101.20840686
35NEK91.19914542
36LYN1.19576826
37ARAF1.18947674
38ACVR1B1.16372994
39TRPM71.15585852
40HCK1.14325223
41TGFBR11.14204495
42TESK21.13935150
43TAOK11.13322675
44LCK1.10627407
45FGR1.10022004
46JAK11.07704700
47SCYL21.04266979
48CSK1.02891029
49MAP3K11.00869994
50DDR21.00145508
51BCKDK0.99070675
52CLK10.97227342
53TAOK30.95237224
54PKN20.94995410
55SIK30.93047043
56MATK0.88864735
57CHUK0.87537190
58EIF2AK10.87209917
59FES0.85729390
60TTN0.84657459
61MAP3K30.83238758
62TESK10.80948201
63VRK20.80507569
64EIF2AK30.80229941
65ABL20.79712124
66MAP3K120.79289444
67MAP3K110.78241017
68PAK40.76578202
69ITK0.76446219
70PRKG20.74691594
71EEF2K0.71821053
72CAMKK20.71672265
73NLK0.70207437
74ILK0.68436776
75CDC42BPA0.66035735
76WEE10.60587194
77RPS6KA60.60414731
78PRKD20.60298477
79MYLK0.60103355
80HIPK20.58420353
81STK40.58399317
82MAP3K50.58052379
83PAK10.57954713
84VRK10.56467692
85BRSK20.56404505
86EIF2AK20.55828239
87MOS0.54028209
88PBK0.53933771
89ADRBK20.53361925
90MARK30.52879832
91PIK3CG0.52838529
92MAPKAPK20.50947610
93DAPK10.50509453
94PRKCD0.50475129
95TAOK20.50154324
96JAK20.49553039
97CDK70.48508946
98DAPK30.47627294
99MUSK0.47272081
100RPS6KL10.45834271
101RPS6KC10.45834271
102ABL10.45809908
103STK160.45804683
104RIPK10.45618454
105GRK60.45263688
106MAPKAPK30.43315553
107PTK2B0.42114509
108MAP3K80.41714130
109FGFR30.40738420
110BMX0.40458784
111TNK20.40143285
112CDK40.39706116
113RAF10.39683656
114MAPK110.39662134
115CDK60.38796930
116EPHB10.38763910
117BUB10.38371848
118MAPK40.38142445
119PRKCQ0.37892131
120FYN0.37775227
121ERBB30.37062628
122EPHA30.36899776
123CDK80.35942745
124RPS6KA50.34972044
125MAP3K130.34491272
126PDK10.33852576
127PDPK10.30515017
128IRAK20.28462152
129MAPK70.27837953
130SIK10.26867905

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.86920122
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51883706
3Ribosome_Homo sapiens_hsa030102.40244171
4DNA replication_Homo sapiens_hsa030302.16310652
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.06584445
6Malaria_Homo sapiens_hsa051442.02901302
7Legionellosis_Homo sapiens_hsa051342.00771102
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99554903
9Measles_Homo sapiens_hsa051621.99121578
10Staphylococcus aureus infection_Homo sapiens_hsa051501.98004888
11Osteoclast differentiation_Homo sapiens_hsa043801.95540918
12Antigen processing and presentation_Homo sapiens_hsa046121.95090310
13Pertussis_Homo sapiens_hsa051331.94602822
14Primary immunodeficiency_Homo sapiens_hsa053401.90823335
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87902087
16Other glycan degradation_Homo sapiens_hsa005111.82273619
17Graft-versus-host disease_Homo sapiens_hsa053321.82117893
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.75456643
19Hematopoietic cell lineage_Homo sapiens_hsa046401.75453257
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74827105
21Allograft rejection_Homo sapiens_hsa053301.73438887
22Shigellosis_Homo sapiens_hsa051311.66752491
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66484704
24Tuberculosis_Homo sapiens_hsa051521.64138525
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63612677
26B cell receptor signaling pathway_Homo sapiens_hsa046621.60321054
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.58645020
28Herpes simplex infection_Homo sapiens_hsa051681.57981730
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53901498
30Proteasome_Homo sapiens_hsa030501.52116665
31Lysosome_Homo sapiens_hsa041421.48070154
32Asthma_Homo sapiens_hsa053101.46183915
33Salmonella infection_Homo sapiens_hsa051321.45339157
34Apoptosis_Homo sapiens_hsa042101.43894417
35Base excision repair_Homo sapiens_hsa034101.36779602
36Toxoplasmosis_Homo sapiens_hsa051451.36609743
37Influenza A_Homo sapiens_hsa051641.35183900
38TNF signaling pathway_Homo sapiens_hsa046681.30061908
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29445110
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.28092718
41Phagosome_Homo sapiens_hsa041451.24945350
42Mismatch repair_Homo sapiens_hsa034301.23260501
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22731743
44Hepatitis B_Homo sapiens_hsa051611.21966832
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19743092
46Rheumatoid arthritis_Homo sapiens_hsa053231.15255774
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13966352
48Viral myocarditis_Homo sapiens_hsa054161.11369339
49Homologous recombination_Homo sapiens_hsa034401.05683665
50Platelet activation_Homo sapiens_hsa046111.03051792
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02903295
52Acute myeloid leukemia_Homo sapiens_hsa052211.02123398
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.01139261
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98006054
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96718260
56Chemokine signaling pathway_Homo sapiens_hsa040620.95079764
57p53 signaling pathway_Homo sapiens_hsa041150.94281162
58Nucleotide excision repair_Homo sapiens_hsa034200.92784315
59Pyrimidine metabolism_Homo sapiens_hsa002400.90965476
60Bladder cancer_Homo sapiens_hsa052190.87276781
61Protein export_Homo sapiens_hsa030600.86358742
62Epstein-Barr virus infection_Homo sapiens_hsa051690.86281774
63Chronic myeloid leukemia_Homo sapiens_hsa052200.84792838
64T cell receptor signaling pathway_Homo sapiens_hsa046600.84294503
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82912430
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78875053
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77816789
68RNA polymerase_Homo sapiens_hsa030200.74102492
69Endocytosis_Homo sapiens_hsa041440.73899067
70Prion diseases_Homo sapiens_hsa050200.73843451
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73565788
72N-Glycan biosynthesis_Homo sapiens_hsa005100.68840620
73Pancreatic cancer_Homo sapiens_hsa052120.68397810
74HTLV-I infection_Homo sapiens_hsa051660.68349523
75Viral carcinogenesis_Homo sapiens_hsa052030.67737043
76Non-homologous end-joining_Homo sapiens_hsa034500.66491826
77African trypanosomiasis_Homo sapiens_hsa051430.66228798
78Spliceosome_Homo sapiens_hsa030400.65569505
79Small cell lung cancer_Homo sapiens_hsa052220.65535123
80Amoebiasis_Homo sapiens_hsa051460.64666516
81Hepatitis C_Homo sapiens_hsa051600.64545058
82Autoimmune thyroid disease_Homo sapiens_hsa053200.63448352
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62570480
84Cell cycle_Homo sapiens_hsa041100.62254753
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60271774
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59618904
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57069065
88Type I diabetes mellitus_Homo sapiens_hsa049400.56196277
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55947087
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55558500
91VEGF signaling pathway_Homo sapiens_hsa043700.55427193
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53281650
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.51923868
94Caffeine metabolism_Homo sapiens_hsa002320.50164693
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.48984708
96Collecting duct acid secretion_Homo sapiens_hsa049660.48859745
97ECM-receptor interaction_Homo sapiens_hsa045120.46235679
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.46214384
99Vibrio cholerae infection_Homo sapiens_hsa051100.45269183
100HIF-1 signaling pathway_Homo sapiens_hsa040660.44663373
101Galactose metabolism_Homo sapiens_hsa000520.44119910
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44082294
103Focal adhesion_Homo sapiens_hsa045100.43522882
104Systemic lupus erythematosus_Homo sapiens_hsa053220.42817204
105RNA degradation_Homo sapiens_hsa030180.41597784
106Non-small cell lung cancer_Homo sapiens_hsa052230.40710072
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39541040
108Proteoglycans in cancer_Homo sapiens_hsa052050.38903857
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37829360
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36570751
111Renin-angiotensin system_Homo sapiens_hsa046140.35655129
112One carbon pool by folate_Homo sapiens_hsa006700.33775010
113Pentose phosphate pathway_Homo sapiens_hsa000300.33542878
114Fanconi anemia pathway_Homo sapiens_hsa034600.32146464
115Complement and coagulation cascades_Homo sapiens_hsa046100.27836562
116Prolactin signaling pathway_Homo sapiens_hsa049170.21402993
117Sphingolipid metabolism_Homo sapiens_hsa006000.19431738
118Fructose and mannose metabolism_Homo sapiens_hsa000510.18228847
119Sulfur metabolism_Homo sapiens_hsa009200.18039070
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15379565
121Glutathione metabolism_Homo sapiens_hsa004800.15355034

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