EML1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.38342025
2central nervous system myelination (GO:0022010)7.38342025
3axon ensheathment (GO:0008366)4.91364738
4ensheathment of neurons (GO:0007272)4.91364738
5myelination (GO:0042552)4.90629834
6fatty acid elongation (GO:0030497)4.64620507
7long-chain fatty acid biosynthetic process (GO:0042759)4.11499329
8regulation of collateral sprouting (GO:0048670)3.90277743
9eye photoreceptor cell differentiation (GO:0001754)3.80875121
10photoreceptor cell differentiation (GO:0046530)3.80875121
11negative regulation of protein localization to cell surface (GO:2000009)3.75158634
12establishment of mitochondrion localization (GO:0051654)3.70191109
13peptidyl-tyrosine autophosphorylation (GO:0038083)3.62129261
14negative regulation of neurotransmitter secretion (GO:0046929)3.60064173
15detection of temperature stimulus involved in sensory perception (GO:0050961)3.58412914
16detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.58412914
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43687457
18myelin maintenance (GO:0043217)3.39547254
19cholesterol biosynthetic process (GO:0006695)3.37076114
20negative regulation of neurotransmitter transport (GO:0051589)3.36285100
21epithelial cilium movement (GO:0003351)3.35035671
22peripheral nervous system axon ensheathment (GO:0032292)3.27264650
23myelination in peripheral nervous system (GO:0022011)3.27264650
24negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.24773380
25postsynaptic membrane organization (GO:0001941)3.23047647
26substantia nigra development (GO:0021762)3.21704213
27response to redox state (GO:0051775)3.20376952
28L-amino acid import (GO:0043092)3.18218364
29negative regulation of axonogenesis (GO:0050771)3.16847355
30detection of temperature stimulus (GO:0016048)3.15819756
31presynaptic membrane organization (GO:0097090)3.10116266
32transmission of nerve impulse (GO:0019226)3.08078126
33intraciliary transport (GO:0042073)3.07878851
34cilium movement (GO:0003341)3.07150558
35pyrimidine nucleobase catabolic process (GO:0006208)3.04457328
36neuron cell-cell adhesion (GO:0007158)3.04282719
37neuronal action potential propagation (GO:0019227)3.03821990
38neuronal ion channel clustering (GO:0045161)3.00335928
39sterol biosynthetic process (GO:0016126)3.00160303
40neuronal action potential (GO:0019228)2.99273996
41cerebral cortex radially oriented cell migration (GO:0021799)2.98136238
42presynaptic membrane assembly (GO:0097105)2.97882416
43synaptic vesicle maturation (GO:0016188)2.95102159
44creatine metabolic process (GO:0006600)2.94512572
45astrocyte development (GO:0014002)2.94299443
46central nervous system projection neuron axonogenesis (GO:0021952)2.93962989
47negative regulation of axon extension (GO:0030517)2.90982054
48negative regulation of axon guidance (GO:1902668)2.83800277
49apical protein localization (GO:0045176)2.83596205
50import into cell (GO:0098657)2.83306443
51nerve growth factor signaling pathway (GO:0038180)2.82433629
52oligodendrocyte differentiation (GO:0048709)2.81863842
53adult walking behavior (GO:0007628)2.80493192
54retinal cone cell development (GO:0046549)2.79550441
55paraxial mesoderm development (GO:0048339)2.77146642
56regulation of cell communication by electrical coupling (GO:0010649)2.77079225
57axonemal dynein complex assembly (GO:0070286)2.76585863
58neuron projection extension involved in neuron projection guidance (GO:1902284)2.75738651
59axon extension involved in axon guidance (GO:0048846)2.75738651
60central nervous system neuron axonogenesis (GO:0021955)2.71125850
61asymmetric protein localization (GO:0008105)2.70072599
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69291603
63cell migration in hindbrain (GO:0021535)2.69019482
64regulation of axon guidance (GO:1902667)2.68657800
65enteric nervous system development (GO:0048484)2.66711957
66neuron remodeling (GO:0016322)2.66354370
67dendrite morphogenesis (GO:0048813)2.64234146
68neuron recognition (GO:0008038)2.64057705
69limb bud formation (GO:0060174)2.63061396
70dendritic spine morphogenesis (GO:0060997)2.62866263
71response to methylmercury (GO:0051597)2.62395982
72artery development (GO:0060840)2.60913711
73protein palmitoylation (GO:0018345)2.60875546
74cellular response to epinephrine stimulus (GO:0071872)2.60455069
75isoprenoid biosynthetic process (GO:0008299)2.59928423
76negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58880514
77appendage development (GO:0048736)2.58771654
78limb development (GO:0060173)2.58771654
79lateral sprouting from an epithelium (GO:0060601)2.58765189
80nonmotile primary cilium assembly (GO:0035058)2.58413249
81glycerophospholipid catabolic process (GO:0046475)2.58138947
82neurofilament cytoskeleton organization (GO:0060052)2.57431164
83positive regulation of action potential (GO:0045760)2.54319403
84retinal ganglion cell axon guidance (GO:0031290)2.53528885
85cilium morphogenesis (GO:0060271)2.53077380
86positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52882069
87peripheral nervous system neuron development (GO:0048935)2.50746996
88olfactory bulb development (GO:0021772)2.50335548
89axonal fasciculation (GO:0007413)2.50169410
90regulation of voltage-gated calcium channel activity (GO:1901385)2.49148392
91behavioral response to nicotine (GO:0035095)2.48767466
92lymphangiogenesis (GO:0001946)2.48757252
93glutamate secretion (GO:0014047)2.47900282
94cellular response to catecholamine stimulus (GO:0071870)2.47772375
95cellular response to monoamine stimulus (GO:0071868)2.47772375
96membrane assembly (GO:0071709)2.47568197
97otic vesicle formation (GO:0030916)2.47132615
98regulation of synaptic vesicle exocytosis (GO:2000300)2.47013784
99long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.46119702
100positive regulation of potassium ion transport (GO:0043268)2.46108761
101regulation of axon extension involved in axon guidance (GO:0048841)2.44059181
102somite development (GO:0061053)2.43885169
103adhesion of symbiont to host cell (GO:0044650)2.43101509
104virion attachment to host cell (GO:0019062)2.43101509
105cilium organization (GO:0044782)2.42572212
106axoneme assembly (GO:0035082)2.42219467
107glycine transport (GO:0015816)2.41879627
108cilium assembly (GO:0042384)2.41121748
109peripheral nervous system development (GO:0007422)2.39290441
110positive regulation of cardiac muscle cell differentiation (GO:2000727)2.39015060
111inner ear receptor stereocilium organization (GO:0060122)2.38649719
112actin filament depolymerization (GO:0030042)2.37744562
113mitochondrion transport along microtubule (GO:0047497)2.37232457
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.37232457
115nucleobase catabolic process (GO:0046113)2.36487223
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35112303
117amino acid import (GO:0043090)2.34553820
118membrane tubulation (GO:0097320)2.34278427
119calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.34138734
120peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.33842969
121negative chemotaxis (GO:0050919)2.32858084
122organelle transport along microtubule (GO:0072384)2.32780075
123regulation of timing of cell differentiation (GO:0048505)2.32713148
124regulation of extent of cell growth (GO:0061387)2.32241242
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.32026310
126response to epinephrine (GO:0071871)2.32013770
127regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31945570
128neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.31199416
129negative regulation of axon extension involved in axon guidance (GO:0048843)2.30966730
130urinary tract smooth muscle contraction (GO:0014848)2.29994653
131cilium or flagellum-dependent cell motility (GO:0001539)2.29515558
132neuromuscular synaptic transmission (GO:0007274)2.29203015
133magnesium ion transport (GO:0015693)2.28193811
134long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.27572775
135outer ear morphogenesis (GO:0042473)2.27491277
136positive regulation of synapse assembly (GO:0051965)2.27314750
137protein localization to synapse (GO:0035418)2.27264624
138locomotory exploration behavior (GO:0035641)2.27088334
139smoothened signaling pathway (GO:0007224)2.26059103
140establishment of planar polarity (GO:0001736)2.26049443
141establishment of tissue polarity (GO:0007164)2.26049443
142axon development (GO:0061564)2.25970826
143response to monoamine (GO:0071867)2.25899339
144response to catecholamine (GO:0071869)2.25899339
145photoreceptor cell maintenance (GO:0045494)2.25676755
146muscle filament sliding (GO:0030049)2.24272984
147actin-myosin filament sliding (GO:0033275)2.24272984
148mating behavior (GO:0007617)2.23870114
149actin-mediated cell contraction (GO:0070252)2.23737391
150positive regulation of gastrulation (GO:2000543)2.22727272
151cellular component assembly involved in morphogenesis (GO:0010927)2.21876549
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.21840529
153regulation of cilium movement (GO:0003352)2.20333927
154short-term memory (GO:0007614)2.20271451
155regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.19555740
156hindbrain development (GO:0030902)2.17069416
157spinal cord development (GO:0021510)2.16773689
158cerebral cortex cell migration (GO:0021795)2.15494469
159regulation of development, heterochronic (GO:0040034)2.15146605
160regulation of synapse assembly (GO:0051963)2.14541376
161cardiac myofibril assembly (GO:0055003)2.14376587
162left/right pattern formation (GO:0060972)2.14334740
163cranial nerve morphogenesis (GO:0021602)2.14014340
164inner ear receptor cell development (GO:0060119)2.13276487
165notochord development (GO:0030903)2.09649139
166regulation of non-canonical Wnt signaling pathway (GO:2000050)2.08665930
167microtubule bundle formation (GO:0001578)2.07823661
168behavioral response to ethanol (GO:0048149)2.07396537
169regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.06210441
170positive regulation of dendritic spine morphogenesis (GO:0061003)2.05889880
171auditory behavior (GO:0031223)2.05629467
172protein localization to cilium (GO:0061512)2.04945169
173protein heterotrimerization (GO:0070208)2.04639040
174renal tubule morphogenesis (GO:0061333)2.03007818
175axon extension (GO:0048675)2.02789710
176regulation of hippo signaling (GO:0035330)2.02752854
177retinal rod cell development (GO:0046548)2.02641020
178cell proliferation in forebrain (GO:0021846)2.01770268
179regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.01604524
180vocalization behavior (GO:0071625)2.01144386
181ephrin receptor signaling pathway (GO:0048013)2.00833862
182myoblast fusion (GO:0007520)1.98936481
183ganglion development (GO:0061548)1.98185337
184myofibril assembly (GO:0030239)1.96535836
185cerebral cortex development (GO:0021987)1.96510810
186establishment of nucleus localization (GO:0040023)1.95711517
187determination of left/right symmetry (GO:0007368)1.95352678
188embryonic body morphogenesis (GO:0010172)1.94580853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.30618469
2EZH2_22144423_ChIP-Seq_EOC_Human3.11617215
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.06398042
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.99164232
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72672447
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68808601
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47426615
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38521327
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38521327
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.36777225
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32214138
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.28979538
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22098718
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19722176
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18625061
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17100797
17IGF1R_20145208_ChIP-Seq_DFB_Human2.15621942
18* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.12407630
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12300088
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.07258552
21* FUS_26573619_Chip-Seq_HEK293_Human2.01113195
22DROSHA_22980978_ChIP-Seq_HELA_Human1.97455434
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94047343
24ZNF274_21170338_ChIP-Seq_K562_Hela1.93602674
25AR_21572438_ChIP-Seq_LNCaP_Human1.90620431
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.84496512
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82972051
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82234173
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.69447452
30VDR_22108803_ChIP-Seq_LS180_Human1.67152946
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65066830
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59785200
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58938000
34TAF15_26573619_Chip-Seq_HEK293_Human1.58819427
35EWS_26573619_Chip-Seq_HEK293_Human1.57913062
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.56504188
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55568755
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52864858
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52404431
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.42576900
41REST_21632747_ChIP-Seq_MESCs_Mouse1.42532543
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.42510925
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.40640596
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38477944
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37988586
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37801966
47CBP_20019798_ChIP-Seq_JUKART_Human1.37801966
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36934984
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36909986
50SMAD4_21799915_ChIP-Seq_A2780_Human1.36900237
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36409659
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36409659
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35386319
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.33840023
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33684409
56AR_25329375_ChIP-Seq_VCAP_Human1.33683192
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33582883
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33291274
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32945596
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.31412180
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30166430
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29819739
63P300_19829295_ChIP-Seq_ESCs_Human1.29725792
64* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29053590
65AHR_22903824_ChIP-Seq_MCF-7_Human1.28846514
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28625539
67ER_23166858_ChIP-Seq_MCF-7_Human1.28413383
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.24861556
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24228073
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22822509
71* STAT3_23295773_ChIP-Seq_U87_Human1.22222723
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21461868
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21267853
74* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20060778
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.19661270
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19240136
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18424534
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18308501
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18308501
80BCAT_22108803_ChIP-Seq_LS180_Human1.18287502
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17946098
82SOX9_26525672_Chip-Seq_HEART_Mouse1.16489648
83* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15044095
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.14880396
85* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14833643
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.14342827
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13938761
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13060592
89* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12935528
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12860381
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.11042818
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11013985
93TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10916524
94TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10768995
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10663640
96* CJUN_26792858_Chip-Seq_BT549_Human1.10365347
97* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09970466
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08589028
99* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08544629
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08097914
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.07744850
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.07114442
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06544831
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05007681
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03603143
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03162841
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02954115
108* SMAD4_21741376_ChIP-Seq_HESCs_Human1.01759119
109TCF4_23295773_ChIP-Seq_U87_Human1.01348149
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97690474
111* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97640811
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97582496
113CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97330177
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95493874
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95248262
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95128267
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95042330
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94512598
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94493673
120TP53_18474530_ChIP-ChIP_U2OS_Human0.92928361
121* PRDM14_20953172_ChIP-Seq_ESCs_Human0.92763859
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92579848
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91585672
124AR_19668381_ChIP-Seq_PC3_Human0.91134557
125RNF2_27304074_Chip-Seq_NSC_Mouse0.90948378
126* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90827555
127* RUNX2_22187159_ChIP-Seq_PCA_Human0.90290734
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89199370
129* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88573332
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.87042688
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.86872029
132SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86804864
133* SMAD4_21741376_ChIP-Seq_EPCs_Human0.86496683
134TP53_16413492_ChIP-PET_HCT116_Human0.86158854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.63092894
2MP0000920_abnormal_myelination3.32924366
3MP0003880_abnormal_central_pattern3.26882398
4MP0001968_abnormal_touch/_nociception3.03515913
5MP0002735_abnormal_chemical_nociception2.82910141
6MP0004859_abnormal_synaptic_plasticity2.70023486
7MP0002736_abnormal_nociception_after2.69532705
8MP0002734_abnormal_mechanical_nocicepti2.58263922
9MP0010030_abnormal_orbit_morphology2.54463774
10MP0002272_abnormal_nervous_system2.42701293
11MP0005171_absent_coat_pigmentation2.27361613
12MP0006292_abnormal_olfactory_placode2.21645590
13MP0003950_abnormal_plasma_membrane2.19892764
14MP0000778_abnormal_nervous_system2.18565491
15MP0002733_abnormal_thermal_nociception2.11796082
16MP0003635_abnormal_synaptic_transmissio2.00939088
17MP0001486_abnormal_startle_reflex1.98838567
18MP0001970_abnormal_pain_threshold1.96664578
19MP0002064_seizures1.93315170
20MP0004885_abnormal_endolymph1.87625180
21MP0003690_abnormal_glial_cell1.87515662
22MP0003329_amyloid_beta_deposits1.84019826
23MP0003634_abnormal_glial_cell1.81149579
24MP0000751_myopathy1.80833524
25MP0009745_abnormal_behavioral_response1.74509603
26MP0005423_abnormal_somatic_nervous1.73831920
27MP0005623_abnormal_meninges_morphology1.73795237
28MP0009046_muscle_twitch1.72477020
29MP0000049_abnormal_middle_ear1.69626284
30MP0004145_abnormal_muscle_electrophysio1.69459617
31MP0006276_abnormal_autonomic_nervous1.69223705
32MP0001299_abnormal_eye_distance/1.66588169
33MP0004742_abnormal_vestibular_system1.64846627
34MP0004858_abnormal_nervous_system1.63404864
35MP0001529_abnormal_vocalization1.61314690
36MP0000749_muscle_degeneration1.59616988
37MP0002067_abnormal_sensory_capabilities1.59418970
38MP0008789_abnormal_olfactory_epithelium1.58495291
39MP0003937_abnormal_limbs/digits/tail_de1.58363749
40MP0008438_abnormal_cutaneous_collagen1.57411545
41MP0001905_abnormal_dopamine_level1.55956994
42MP0000955_abnormal_spinal_cord1.55707984
43MP0002234_abnormal_pharynx_morphology1.55213851
44MP0001485_abnormal_pinna_reflex1.52221683
45MP0004036_abnormal_muscle_relaxation1.51682315
46MP0002063_abnormal_learning/memory/cond1.49620358
47MP0004142_abnormal_muscle_tone1.48190378
48MP0002233_abnormal_nose_morphology1.44946487
49MP0002882_abnormal_neuron_morphology1.43183282
50MP0004133_heterotaxia1.42966379
51MP0002938_white_spotting1.40746609
52MP0002229_neurodegeneration1.38853336
53MP0002102_abnormal_ear_morphology1.38316715
54MP0000747_muscle_weakness1.38151143
55MP0002572_abnormal_emotion/affect_behav1.37808784
56MP0002184_abnormal_innervation1.37709681
57MP0004134_abnormal_chest_morphology1.36652483
58MP0001986_abnormal_taste_sensitivity1.36013408
59MP0006072_abnormal_retinal_apoptosis1.35043180
60MP0001293_anophthalmia1.32922552
61MP0001440_abnormal_grooming_behavior1.31233273
62MP0002837_dystrophic_cardiac_calcinosis1.30307342
63MP0000462_abnormal_digestive_system1.28459120
64MP0003632_abnormal_nervous_system1.27997841
65MP0003755_abnormal_palate_morphology1.26965676
66MP0005275_abnormal_skin_tensile1.26883820
67MP0005187_abnormal_penis_morphology1.25513236
68MP0005551_abnormal_eye_electrophysiolog1.24907755
69MP0005248_abnormal_Harderian_gland1.22879496
70MP0002653_abnormal_ependyma_morphology1.22243234
71MP0000566_synostosis1.21093961
72MP0000631_abnormal_neuroendocrine_gland1.20855474
73MP0005253_abnormal_eye_physiology1.20568207
74MP0003942_abnormal_urinary_system1.20159905
75MP0005499_abnormal_olfactory_system1.16332180
76MP0005394_taste/olfaction_phenotype1.16332180
77MP0003631_nervous_system_phenotype1.16273882
78MP0002752_abnormal_somatic_nervous1.16248310
79MP0000569_abnormal_digit_pigmentation1.16063520
80MP0002066_abnormal_motor_capabilities/c1.15081292
81MP0003137_abnormal_impulse_conducting1.14835764
82MP0004084_abnormal_cardiac_muscle1.14365246
83MP0003283_abnormal_digestive_organ1.14177614
84MP0010368_abnormal_lymphatic_system1.13777070
85MP0003633_abnormal_nervous_system1.13678022
86MP0003646_muscle_fatigue1.12638468
87MP0008569_lethality_at_weaning1.12464099
88MP0009384_cardiac_valve_regurgitation1.10737039
89MP0002697_abnormal_eye_size1.09518889
90MP0009780_abnormal_chondrocyte_physiolo1.09322939
91MP0005386_behavior/neurological_phenoty1.09005671
92MP0004924_abnormal_behavior1.09005671
93MP0005409_darkened_coat_color1.05323402
94MP0003119_abnormal_digestive_system1.04856501
95MP0002160_abnormal_reproductive_system1.03716398
96MP0001286_abnormal_eye_development1.03360572
97MP0003122_maternal_imprinting1.02004410
98MP0004085_abnormal_heartbeat1.01760664
99MP0003861_abnormal_nervous_system1.01122354
100MP0005503_abnormal_tendon_morphology1.00384382
101MP0003890_abnormal_embryonic-extraembry0.99836019
102MP0004811_abnormal_neuron_physiology0.99427229
103MP0002127_abnormal_cardiovascular_syste0.98885967
104MP0001984_abnormal_olfaction0.98014774
105MP0003935_abnormal_craniofacial_develop0.97770561
106MP0004272_abnormal_basement_membrane0.97555163
107MP0000428_abnormal_craniofacial_morphol0.97243508
108MP0008877_abnormal_DNA_methylation0.96266490
109MP0002108_abnormal_muscle_morphology0.95659167
110MP0003938_abnormal_ear_development0.95603407
111MP0005620_abnormal_muscle_contractility0.95527505
112MP0009053_abnormal_anal_canal0.95521593
113MP0001346_abnormal_lacrimal_gland0.95260059
114MP0004215_abnormal_myocardial_fiber0.94575376
115MP0003385_abnormal_body_wall0.93236560
116MP0010386_abnormal_urinary_bladder0.92138003
117MP0005391_vision/eye_phenotype0.92083661
118MP0003567_abnormal_fetal_cardiomyocyte0.91220951
119MP0002295_abnormal_pulmonary_circulatio0.90893556
120MP0002638_abnormal_pupillary_reflex0.89971812
121MP0004147_increased_porphyrin_level0.88879787
122MP0000427_abnormal_hair_cycle0.88760630
123MP0000013_abnormal_adipose_tissue0.86810173
124MP0002116_abnormal_craniofacial_bone0.86583597
125MP0001963_abnormal_hearing_physiology0.86500355
126MP0000026_abnormal_inner_ear0.85595489
127MP0002282_abnormal_trachea_morphology0.85537116
128MP0002972_abnormal_cardiac_muscle0.85291527
129MP0001177_atelectasis0.84981280
130MP0000762_abnormal_tongue_morphology0.83839680
131MP0000759_abnormal_skeletal_muscle0.82926045
132MP0003136_yellow_coat_color0.82656655
133MP0002557_abnormal_social/conspecific_i0.82621929
134MP0002751_abnormal_autonomic_nervous0.81241661
135MP0002152_abnormal_brain_morphology0.79051204
136MP0001958_emphysema0.78175145
137MP0000534_abnormal_ureter_morphology0.77429636
138MP0008260_abnormal_autophagy0.77084375
139MP0009250_abnormal_appendicular_skeleto0.76669186
140MP0000003_abnormal_adipose_tissue0.75877017
141MP0010678_abnormal_skin_adnexa0.75251404
142MP0005330_cardiomyopathy0.75018582
143MP0005410_abnormal_fertilization0.74072489
144MP0005369_muscle_phenotype0.73362478
145MP0004043_abnormal_pH_regulation0.72953952
146MP0005195_abnormal_posterior_eye0.72603850
147MP0004087_abnormal_muscle_fiber0.70360781
148MP0000372_irregular_coat_pigmentation0.70007023
149MP0002822_catalepsy0.69093207
150MP0000383_abnormal_hair_follicle0.68639748

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.77693917
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.77693917
3Neurofibrillary tangles (HP:0002185)4.11967361
4Abnormality of the corticospinal tract (HP:0002492)4.09630604
5Sensory axonal neuropathy (HP:0003390)3.96023268
6Termporal pattern (HP:0011008)3.87527606
7Insidious onset (HP:0003587)3.87527606
8Onion bulb formation (HP:0003383)3.84670958
9Supranuclear gaze palsy (HP:0000605)3.55771060
10Peripheral hypomyelination (HP:0007182)3.52325581
11Pheochromocytoma (HP:0002666)3.47333372
12Myokymia (HP:0002411)3.36046686
13Ankle clonus (HP:0011448)3.26918566
14Parakeratosis (HP:0001036)3.17379995
15Action tremor (HP:0002345)3.08841014
16Type 1 muscle fiber predominance (HP:0003803)3.07405415
17Spastic gait (HP:0002064)3.03869394
18Ulnar claw (HP:0001178)3.02765563
19Cerebral inclusion bodies (HP:0100314)3.01473693
20Hyporeflexia of lower limbs (HP:0002600)2.99755432
21Cerebral hypomyelination (HP:0006808)2.99389133
22Segmental peripheral demyelination/remyelination (HP:0003481)2.93073433
23Neuroendocrine neoplasm (HP:0100634)2.93027269
24Retinal dysplasia (HP:0007973)2.88653980
25Pancreatic fibrosis (HP:0100732)2.87552241
26Akinesia (HP:0002304)2.82735641
27Molar tooth sign on MRI (HP:0002419)2.75970177
28Abnormality of midbrain morphology (HP:0002418)2.75970177
29Muscle fiber splitting (HP:0003555)2.75876452
30Foot dorsiflexor weakness (HP:0009027)2.75175927
31Steppage gait (HP:0003376)2.73291288
32True hermaphroditism (HP:0010459)2.69746308
33Hammertoe (HP:0001765)2.67644218
34Pancreatic cysts (HP:0001737)2.67108464
35Aplasia involving bones of the upper limbs (HP:0009823)2.63944404
36Aplasia of the phalanges of the hand (HP:0009802)2.63944404
37Aplasia involving bones of the extremities (HP:0009825)2.63944404
38Dysmetria (HP:0001310)2.62695388
39Medial flaring of the eyebrow (HP:0010747)2.62306187
40Alacrima (HP:0000522)2.60293850
41Nephronophthisis (HP:0000090)2.58065418
42Scanning speech (HP:0002168)2.56094244
43Atonic seizures (HP:0010819)2.55512685
44Intention tremor (HP:0002080)2.54236875
45Abnormality of the foot musculature (HP:0001436)2.51310977
46Occipital encephalocele (HP:0002085)2.47441100
47Lower limb muscle weakness (HP:0007340)2.42323309
48Muscle hypertrophy of the lower extremities (HP:0008968)2.40411781
49Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.39482173
50Gait imbalance (HP:0002141)2.38629394
51Focal seizures (HP:0007359)2.33835620
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.33506552
53Decreased motor nerve conduction velocity (HP:0003431)2.33083901
54Muscle fiber inclusion bodies (HP:0100299)2.32051004
55Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31303014
56Focal motor seizures (HP:0011153)2.30332839
57Limb dystonia (HP:0002451)2.27876547
58Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.25303909
59Cerebral hemorrhage (HP:0001342)2.25245327
60Intestinal atresia (HP:0011100)2.24960373
61Congenital primary aphakia (HP:0007707)2.24584669
62Nemaline bodies (HP:0003798)2.24470492
63Difficulty running (HP:0009046)2.23202186
64Abnormal ciliary motility (HP:0012262)2.17275382
65Abnormal auditory evoked potentials (HP:0006958)2.16912130
66Chronic hepatic failure (HP:0100626)2.14661500
67Slow saccadic eye movements (HP:0000514)2.14632903
68Abnormal respiratory epithelium morphology (HP:0012253)2.13780736
69Abnormal respiratory motile cilium morphology (HP:0005938)2.13780736
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11943005
71Abnormality of the renal medulla (HP:0100957)2.11290829
72Distal sensory impairment (HP:0002936)2.10597075
73Abnormality of glycolysis (HP:0004366)2.09683269
74Increased serum pyruvate (HP:0003542)2.09683269
75Optic nerve hypoplasia (HP:0000609)2.08773808
76Cystic liver disease (HP:0006706)2.07461610
77Postaxial hand polydactyly (HP:0001162)2.05538082
78Autoamputation (HP:0001218)2.04442889
79Exercise-induced muscle cramps (HP:0003710)2.04103313
80Abnormal respiratory motile cilium physiology (HP:0012261)2.03898412
81Septo-optic dysplasia (HP:0100842)2.03501020
82Supernumerary spleens (HP:0009799)2.03289004
83Stridor (HP:0010307)2.03041180
84Abnormality of the labia minora (HP:0012880)2.02776811
85Broad metatarsal (HP:0001783)2.01698647
86Decreased lacrimation (HP:0000633)2.01660577
87Hyperventilation (HP:0002883)2.00316522
88Hypoplasia of the iris (HP:0007676)1.99884115
89Cutaneous finger syndactyly (HP:0010554)1.99447191
90Broad-based gait (HP:0002136)1.99323856
91Bifid tongue (HP:0010297)1.97033971
92Nephrogenic diabetes insipidus (HP:0009806)1.96574978
93Coronal craniosynostosis (HP:0004440)1.96290097
94Calf muscle hypertrophy (HP:0008981)1.96090068
95Megalencephaly (HP:0001355)1.95479833
96Wrist flexion contracture (HP:0001239)1.95158832
97Rhinitis (HP:0012384)1.94356704
98Rimmed vacuoles (HP:0003805)1.94199975
99Urinary urgency (HP:0000012)1.94067250
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93747062
101Scapular winging (HP:0003691)1.93633185
102Preaxial foot polydactyly (HP:0001841)1.90957580
103EMG: myopathic abnormalities (HP:0003458)1.90438896
104Leukodystrophy (HP:0002415)1.89676837
105Anencephaly (HP:0002323)1.88287335
106Hypomagnesemia (HP:0002917)1.88279511
107Postaxial foot polydactyly (HP:0001830)1.88019915
108Prolonged QT interval (HP:0001657)1.87451970
109Poor speech (HP:0002465)1.86223621
110Sclerocornea (HP:0000647)1.86120506
111Abnormality of the calf musculature (HP:0001430)1.85657730
112Absent septum pellucidum (HP:0001331)1.84683295
113Type II lissencephaly (HP:0007260)1.84573799
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83647439
115Deformed tarsal bones (HP:0008119)1.83516034
116Progressive cerebellar ataxia (HP:0002073)1.83038801
117Vaginal atresia (HP:0000148)1.81552097
118Myotonia (HP:0002486)1.80949813
119Hypoplasia of the brainstem (HP:0002365)1.79869967
120Aplasia/Hypoplasia of the brainstem (HP:0007362)1.79869967
121Hypoplastic pelvis (HP:0008839)1.79635113
122Colon cancer (HP:0003003)1.79025229
123Clonus (HP:0002169)1.78799730
124Increased circulating renin level (HP:0000848)1.78025900
125Genital tract atresia (HP:0001827)1.77444335
126Abnormality of abdominal situs (HP:0011620)1.76680495
127Abdominal situs inversus (HP:0003363)1.76680495
128Cutaneous syndactyly (HP:0012725)1.76254387
129Gowers sign (HP:0003391)1.75094966
130Tubulointerstitial nephritis (HP:0001970)1.74858624
131Epileptic encephalopathy (HP:0200134)1.74749592
132Absent/shortened dynein arms (HP:0200106)1.74627418
133Dynein arm defect of respiratory motile cilia (HP:0012255)1.74627418
134Calcaneovalgus deformity (HP:0001848)1.74050300
135Broad foot (HP:0001769)1.73667758
136Premature rupture of membranes (HP:0001788)1.73384704
137Thickened helices (HP:0000391)1.72781406
138Increased variability in muscle fiber diameter (HP:0003557)1.72731242
139Anteriorly placed anus (HP:0001545)1.72685220
140Drooling (HP:0002307)1.72561490
141Bell-shaped thorax (HP:0001591)1.72117722
142Distal arthrogryposis (HP:0005684)1.72115083
143Aqueductal stenosis (HP:0002410)1.71958435
144Hip contracture (HP:0003273)1.71936737
145Renal hypoplasia (HP:0000089)1.71098344
146Abnormality of dentin (HP:0010299)1.71060235
147Slender build (HP:0001533)1.71050213
148Ankle contracture (HP:0006466)1.70937072
149Buphthalmos (HP:0000557)1.70633795
150Narrow forehead (HP:0000341)1.70395318
151Limited hip movement (HP:0008800)1.70358970
152Bradycardia (HP:0001662)1.69719844
153Premature skin wrinkling (HP:0100678)1.67808825
154Chin dimple (HP:0010751)1.67175825
155Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66989475
156Short 4th metacarpal (HP:0010044)1.66989475
157Absent speech (HP:0001344)1.66614355
158Central scotoma (HP:0000603)1.66544756
159Spinal rigidity (HP:0003306)1.65428198
160Soft skin (HP:0000977)1.64693396
161CNS hypomyelination (HP:0003429)1.64314251
162Follicular hyperkeratosis (HP:0007502)1.63973493
163Postural tremor (HP:0002174)1.63712330
164Limb-girdle muscle weakness (HP:0003325)1.63519438
165Exercise-induced myalgia (HP:0003738)1.62827296
166Abnormality of the ischium (HP:0003174)1.62788972
167Sudden death (HP:0001699)1.62354278
168Anophthalmia (HP:0000528)1.61933955
169Abnormality of the parathyroid morphology (HP:0011766)1.60414219
170Increased corneal curvature (HP:0100692)1.59818163
171Tubular atrophy (HP:0000092)1.58638900
172Poor coordination (HP:0002370)1.58150332
173Preaxial hand polydactyly (HP:0001177)1.57445372
174Short foot (HP:0001773)1.57159679
175High anterior hairline (HP:0009890)1.56597663
176Abnormality of the phalanges of the 2nd finger (HP:0009541)1.56576954
177Intellectual disability, moderate (HP:0002342)1.55855059
178Congenital hepatic fibrosis (HP:0002612)1.53157289
179Abnormality of the antihelix (HP:0009738)1.52985746
180Cerebellar dysplasia (HP:0007033)1.52039433
181Aplasia/Hypoplasia of the tibia (HP:0005772)1.51375316
182Round ear (HP:0100830)1.49613618
183Infantile muscular hypotonia (HP:0008947)1.48396357
184Pachygyria (HP:0001302)1.46495688
185Aplasia/Hypoplasia of the lens (HP:0008063)1.46234636
186Fibular hypoplasia (HP:0003038)1.44142080
187Proximal amyotrophy (HP:0007126)1.43463901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.34605998
2OXSR13.42374635
3EPHB13.10839677
4NTRK12.75486639
5TNIK2.70969649
6LIMK12.45547666
7WNK32.44058056
8BCR2.36926406
9WNK42.33538849
10PKN12.18757382
11FRK2.17131406
12PHKG21.94927883
13PHKG11.94927883
14MET1.90381647
15PAK61.87090605
16FGFR21.86680696
17UHMK11.84459941
18WNK11.84251456
19GRK11.69795817
20MARK11.67817882
21PAK31.57159543
22NTRK31.52601684
23ROCK21.51853255
24NEK61.50743354
25MAP4K21.50189185
26MAPKAPK51.49780874
27CDK191.49191933
28NUAK11.48719491
29SGK4941.42219791
30SGK2231.42219791
31STK38L1.41132387
32CAMK2D1.40931152
33TRIM281.39409375
34CAMK2B1.32842338
35ERBB31.28681755
36CSNK1A1L1.24710522
37MINK11.24394973
38CSNK1G31.23684875
39KSR21.22025370
40LATS11.20958452
41MAPK131.20191516
42MKNK21.19306673
43ICK1.18549202
44MAPK151.17900130
45LMTK21.15986029
46EPHA41.15738462
47MAP3K21.13615425
48CSNK1G21.12241588
49AKT31.11858859
50ADRBK21.11356783
51CCNB11.11299731
52CASK1.10556758
53PRPF4B1.07926149
54CDK51.05432534
55TYRO31.05016360
56PNCK1.03396197
57CAMK2G0.97616569
58CAMK2A0.95981466
59CDK140.95692062
60MAP3K90.95363456
61NEK10.95327569
62PRKCE0.92644979
63DYRK20.91332213
64PRKD10.87622671
65TTN0.87330773
66CSNK1G10.86815515
67MKNK10.86513323
68DMPK0.85594213
69ROCK10.84945709
70RET0.84803349
71DDR20.84769536
72MAP3K40.83804135
73PBK0.81582102
74PRKD30.80403466
75OBSCN0.79222879
76MARK20.78508987
77IRAK20.78325712
78PLK30.75938491
79CDK150.73500732
80PTK2B0.73411270
81CDK180.72725561
82FGR0.72663671
83DYRK30.71365805
84PIK3CA0.71234263
85FER0.70428126
86PLK40.69652582
87EPHB20.68863416
88GRK50.68591620
89ADRBK10.67504374
90VRK10.65841398
91PLK20.65548686
92TGFBR10.65387770
93INSRR0.65148835
94PDPK10.64954539
95DYRK1A0.64915792
96MUSK0.64527442
97TIE10.62692657
98CDK11A0.62333747
99LATS20.60454047
100ZAK0.59341243
101BRSK20.56328558
102KSR10.55809453
103FYN0.55492318
104PDGFRB0.54367962
105EPHA30.54009523
106PRKCH0.53731082
107ARAF0.53673506
108PDGFRA0.53666251
109NEK20.53440290
110PTK20.52644680
111WEE10.52413445
112SRPK10.51889875
113MYLK0.51533292
114NTRK20.51134094
115TTK0.49594988
116STK30.49438494
117PRKCQ0.49073911
118ERBB40.48029501
119PLK10.47866731
120FGFR10.47701658
121PRKG10.47303677
122CAMK10.46246751
123MAP2K70.45912924
124MAP3K70.45535983
125CDC42BPA0.45332570
126PINK10.44362978
127PRKCG0.43554800
128CAMK1G0.43414122
129DYRK1B0.42569719
130PRKACB0.42137938
131TSSK60.41722672
132PRKAA10.40600336
133BMPR1B0.40455968
134TESK20.39271230
135PRKD20.39080659
136CAMKK20.37787700
137PRKACA0.37272935
138DAPK20.37087854
139TRPM70.37081557
140IRAK10.35905591
141PDK20.35105114
142PDK10.34252052

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.04875100
2Steroid biosynthesis_Homo sapiens_hsa001003.10588537
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.68642543
4Fatty acid elongation_Homo sapiens_hsa000622.58461514
5Axon guidance_Homo sapiens_hsa043602.14985923
6Ether lipid metabolism_Homo sapiens_hsa005651.86858164
7Basal cell carcinoma_Homo sapiens_hsa052171.85097778
8Glutamatergic synapse_Homo sapiens_hsa047241.74371060
9Synaptic vesicle cycle_Homo sapiens_hsa047211.73483743
10GABAergic synapse_Homo sapiens_hsa047271.65754020
11Propanoate metabolism_Homo sapiens_hsa006401.62611553
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59331243
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55043696
14Serotonergic synapse_Homo sapiens_hsa047261.53986057
15Circadian entrainment_Homo sapiens_hsa047131.52589148
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48601653
17Morphine addiction_Homo sapiens_hsa050321.47139520
18Cholinergic synapse_Homo sapiens_hsa047251.45865926
19Dopaminergic synapse_Homo sapiens_hsa047281.39777904
20Circadian rhythm_Homo sapiens_hsa047101.38761684
21Phototransduction_Homo sapiens_hsa047441.35921978
22Cardiac muscle contraction_Homo sapiens_hsa042601.34769039
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33179036
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30056633
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28348165
26Olfactory transduction_Homo sapiens_hsa047401.28228398
27Long-term depression_Homo sapiens_hsa047301.27711660
28Dilated cardiomyopathy_Homo sapiens_hsa054141.27338915
29Salivary secretion_Homo sapiens_hsa049701.27133301
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26145091
31TGF-beta signaling pathway_Homo sapiens_hsa043501.25496336
32Oxidative phosphorylation_Homo sapiens_hsa001901.23568495
33Vibrio cholerae infection_Homo sapiens_hsa051101.23106248
34Gastric acid secretion_Homo sapiens_hsa049711.22623358
35Sulfur metabolism_Homo sapiens_hsa009201.22560572
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.21682179
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18810448
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18112640
39Tight junction_Homo sapiens_hsa045301.17934320
40Nitrogen metabolism_Homo sapiens_hsa009101.17609973
41Insulin secretion_Homo sapiens_hsa049111.17219868
42Taste transduction_Homo sapiens_hsa047421.17111247
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16038328
44Basal transcription factors_Homo sapiens_hsa030221.15401560
45Fanconi anemia pathway_Homo sapiens_hsa034601.13000737
46Gap junction_Homo sapiens_hsa045401.12918555
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11061715
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10686855
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09996890
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09903054
51Nicotine addiction_Homo sapiens_hsa050331.09147644
52Renal cell carcinoma_Homo sapiens_hsa052111.09023646
53Cocaine addiction_Homo sapiens_hsa050301.04599532
54Alzheimers disease_Homo sapiens_hsa050101.04345183
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.03728739
56Wnt signaling pathway_Homo sapiens_hsa043101.03686035
57Sphingolipid metabolism_Homo sapiens_hsa006001.03254438
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03064791
59Dorso-ventral axis formation_Homo sapiens_hsa043201.02917546
60Non-homologous end-joining_Homo sapiens_hsa034501.00913060
61Collecting duct acid secretion_Homo sapiens_hsa049661.00842610
62Long-term potentiation_Homo sapiens_hsa047201.00720271
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00706131
64Renin secretion_Homo sapiens_hsa049241.00087135
65Oxytocin signaling pathway_Homo sapiens_hsa049210.98224026
66ECM-receptor interaction_Homo sapiens_hsa045120.98011148
67Parkinsons disease_Homo sapiens_hsa050120.95001203
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93314768
69Ras signaling pathway_Homo sapiens_hsa040140.92087408
70Adherens junction_Homo sapiens_hsa045200.91140118
71Endocytosis_Homo sapiens_hsa041440.89569269
72ErbB signaling pathway_Homo sapiens_hsa040120.89376976
73Amphetamine addiction_Homo sapiens_hsa050310.88618549
74Pancreatic secretion_Homo sapiens_hsa049720.87531115
75Huntingtons disease_Homo sapiens_hsa050160.87233258
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.86963084
77Arginine and proline metabolism_Homo sapiens_hsa003300.86944336
78Calcium signaling pathway_Homo sapiens_hsa040200.85100472
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84678687
80GnRH signaling pathway_Homo sapiens_hsa049120.82966598
81Butanoate metabolism_Homo sapiens_hsa006500.78671448
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78665147
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78542452
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77481464
85cAMP signaling pathway_Homo sapiens_hsa040240.76898929
86Homologous recombination_Homo sapiens_hsa034400.75844577
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75355444
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75003946
89beta-Alanine metabolism_Homo sapiens_hsa004100.74760775
90Melanoma_Homo sapiens_hsa052180.74568092
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74561737
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74389964
93Melanogenesis_Homo sapiens_hsa049160.73951651
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73509386
95Selenocompound metabolism_Homo sapiens_hsa004500.73311304
96Oocyte meiosis_Homo sapiens_hsa041140.73197351
97Focal adhesion_Homo sapiens_hsa045100.70935787
98Lysine degradation_Homo sapiens_hsa003100.70654177
99Choline metabolism in cancer_Homo sapiens_hsa052310.69069100
100Tryptophan metabolism_Homo sapiens_hsa003800.64714317
101Hedgehog signaling pathway_Homo sapiens_hsa043400.63291639
102Rap1 signaling pathway_Homo sapiens_hsa040150.62990686
103Estrogen signaling pathway_Homo sapiens_hsa049150.62177245
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61693185
105Glucagon signaling pathway_Homo sapiens_hsa049220.61266896
106Ovarian steroidogenesis_Homo sapiens_hsa049130.59936165
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58190756
108Phagosome_Homo sapiens_hsa041450.57453866
109Type II diabetes mellitus_Homo sapiens_hsa049300.55904511
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55839374
111Protein export_Homo sapiens_hsa030600.54405141
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53930527
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53902341
114Linoleic acid metabolism_Homo sapiens_hsa005910.53886554
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53824795
116MAPK signaling pathway_Homo sapiens_hsa040100.53436189
117Mineral absorption_Homo sapiens_hsa049780.53207389
118Thyroid hormone synthesis_Homo sapiens_hsa049180.52487728
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52475153
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51962856
121Rheumatoid arthritis_Homo sapiens_hsa053230.51898626
122Protein digestion and absorption_Homo sapiens_hsa049740.51542889
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50327922
124Purine metabolism_Homo sapiens_hsa002300.49845810
125Glioma_Homo sapiens_hsa052140.47483741
126AMPK signaling pathway_Homo sapiens_hsa041520.46723543
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.46642387
128Hippo signaling pathway_Homo sapiens_hsa043900.46349786
129Fatty acid metabolism_Homo sapiens_hsa012120.44771728
130RNA degradation_Homo sapiens_hsa030180.44680347
131Salmonella infection_Homo sapiens_hsa051320.43769504
132Pyruvate metabolism_Homo sapiens_hsa006200.43610832
133Histidine metabolism_Homo sapiens_hsa003400.43019448
134Alcoholism_Homo sapiens_hsa050340.38904187
135Proteoglycans in cancer_Homo sapiens_hsa052050.38897357
136MicroRNAs in cancer_Homo sapiens_hsa052060.38838346
137RNA polymerase_Homo sapiens_hsa030200.38557561

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