EMILIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.99584266
2collagen fibril organization (GO:0030199)5.29989443
3Golgi transport vesicle coating (GO:0048200)5.02603865
4COPI coating of Golgi vesicle (GO:0048205)5.02603865
5basement membrane organization (GO:0071711)4.86829834
6sequestering of extracellular ligand from receptor (GO:0035581)4.70363009
7virion attachment to host cell (GO:0019062)4.68763536
8adhesion of symbiont to host cell (GO:0044650)4.68763536
9extracellular matrix assembly (GO:0085029)4.54581661
10bone trabecula formation (GO:0060346)4.53175041
11blood vessel maturation (GO:0001955)4.31617692
12type B pancreatic cell proliferation (GO:0044342)4.24060840
13adhesion of symbiont to host (GO:0044406)4.14820876
14collagen metabolic process (GO:0032963)4.11633230
15cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.08903471
16endodermal cell differentiation (GO:0035987)4.08683169
17vascular endothelial growth factor signaling pathway (GO:0038084)4.08326868
18collagen catabolic process (GO:0030574)4.08112700
19skin morphogenesis (GO:0043589)4.03202176
20tooth mineralization (GO:0034505)4.03193164
21apoptotic cell clearance (GO:0043277)3.96113992
22chondrocyte proliferation (GO:0035988)3.84758685
23multicellular organismal macromolecule metabolic process (GO:0044259)3.80921113
24negative regulation of smooth muscle cell migration (GO:0014912)3.77645672
25multicellular organismal catabolic process (GO:0044243)3.75948016
26cell migration involved in heart development (GO:0060973)3.73165832
27extracellular matrix disassembly (GO:0022617)3.66634401
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.64037041
29barbed-end actin filament capping (GO:0051016)3.58360953
30multicellular organismal metabolic process (GO:0044236)3.58324469
31negative regulation of fatty acid transport (GO:2000192)3.58261148
32cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.52515841
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.50148236
34keratan sulfate catabolic process (GO:0042340)3.41817184
35axon extension involved in axon guidance (GO:0048846)3.41021639
36neuron projection extension involved in neuron projection guidance (GO:1902284)3.41021639
37protein retention in ER lumen (GO:0006621)3.33930663
38fibril organization (GO:0097435)3.29332052
39exocrine pancreas development (GO:0031017)3.27559048
40regulation of extracellular matrix disassembly (GO:0010715)3.27431687
41peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.27099366
42stress fiber assembly (GO:0043149)3.24861465
43retina vasculature morphogenesis in camera-type eye (GO:0061299)3.22597430
44regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22010839
45cellular response to vitamin D (GO:0071305)3.21757784
46chondroitin sulfate biosynthetic process (GO:0030206)3.13302512
47definitive hemopoiesis (GO:0060216)3.09598080
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.09581415
49peptidyl-proline hydroxylation (GO:0019511)3.09030977
50mesenchymal-epithelial cell signaling (GO:0060638)3.07733775
51glial cell migration (GO:0008347)3.07151625
52venous blood vessel morphogenesis (GO:0048845)3.01761065
53activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.01595878
54positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.01027773
55extracellular fibril organization (GO:0043206)2.98727304
56cell adhesion mediated by integrin (GO:0033627)2.97031396
57chondroitin sulfate catabolic process (GO:0030207)2.96395939
58positive regulation of nuclease activity (GO:0032075)2.95384658
59glomerular basement membrane development (GO:0032836)2.94182007
60cellular response to vitamin (GO:0071295)2.92433877
61positive regulation of blood vessel endothelial cell migration (GO:0043536)2.90839066
62metanephric mesenchyme development (GO:0072075)2.87892429
63cell proliferation involved in metanephros development (GO:0072203)2.87450735
64cell-substrate junction assembly (GO:0007044)2.85302050
65outer ear morphogenesis (GO:0042473)2.84790704
66insulin-like growth factor receptor signaling pathway (GO:0048009)2.84760661
67endothelial cell morphogenesis (GO:0001886)2.84677836
68wound healing, spreading of epidermal cells (GO:0035313)2.84437632
69hypotonic response (GO:0006971)2.83952773
70positive regulation of osteoblast proliferation (GO:0033690)2.81846683
71lymph vessel development (GO:0001945)2.79489621
72anatomical structure regression (GO:0060033)2.79077970
73vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76481093
74hyaluronan catabolic process (GO:0030214)2.73880534
75kidney mesenchyme development (GO:0072074)2.73431119
76substrate adhesion-dependent cell spreading (GO:0034446)2.73264873
77endothelial cell chemotaxis (GO:0035767)2.71535051
78negative regulation of focal adhesion assembly (GO:0051895)2.70910362
79negative regulation of cell junction assembly (GO:1901889)2.70910362
80negative regulation of adherens junction organization (GO:1903392)2.70910362
81positive regulation of hormone biosynthetic process (GO:0046886)2.70883523
82heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.70698808
83adherens junction assembly (GO:0034333)2.69573603
84lung vasculature development (GO:0060426)2.69233789
85response to fluid shear stress (GO:0034405)2.69203839
86glomerular filtration (GO:0003094)2.68744859
87cellular response to amino acid stimulus (GO:0071230)2.68500686
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67537986
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67537986
90negative regulation of chondrocyte differentiation (GO:0032331)2.67375799
91regulation of apoptotic cell clearance (GO:2000425)2.67039875
92negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.65250410
93dermatan sulfate biosynthetic process (GO:0030208)2.64884822
94* extracellular matrix organization (GO:0030198)2.64509503
95regulation of plasminogen activation (GO:0010755)2.64197651
96regulation of smooth muscle cell migration (GO:0014910)2.63727449
97regulation of nuclease activity (GO:0032069)2.63329156
98* extracellular structure organization (GO:0043062)2.63025947
99regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.62776981
100positive regulation of receptor recycling (GO:0001921)2.62766191
101positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.62607839
102negative regulation of phagocytosis (GO:0050765)2.61808874
103regulation of collagen metabolic process (GO:0010712)2.61289437
104smooth muscle tissue development (GO:0048745)2.61084370
105Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60926011
106protein hydroxylation (GO:0018126)2.60857797
107endoplasmic reticulum unfolded protein response (GO:0030968)2.58627253
108blood vessel endothelial cell migration (GO:0043534)2.58495271
109positive regulation of endothelial cell apoptotic process (GO:2000353)2.58392865
110embryo implantation (GO:0007566)2.57966366
111branching involved in salivary gland morphogenesis (GO:0060445)2.57347013
112UV protection (GO:0009650)2.57179420
113substrate-dependent cell migration (GO:0006929)2.56849295
114positive regulation of epithelial to mesenchymal transition (GO:0010718)2.56661610
115muscle cell migration (GO:0014812)2.55816128
116negative regulation of erythrocyte differentiation (GO:0045647)2.54584404
117germ cell migration (GO:0008354)2.53814950
118mannose metabolic process (GO:0006013)2.52296598
119endocardial cushion development (GO:0003197)2.52255112
120COPII vesicle coating (GO:0048208)2.51152785
121protein localization to endosome (GO:0036010)2.51046262
122negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.50933181
123cell-substrate adherens junction assembly (GO:0007045)2.49367554
124focal adhesion assembly (GO:0048041)2.49367554
125cell migration involved in sprouting angiogenesis (GO:0002042)2.49255574
126plasma membrane repair (GO:0001778)2.49245614
127dermatan sulfate metabolic process (GO:0030205)2.48642595
128positive regulation of extracellular matrix organization (GO:1903055)2.48610384
129positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.46478410
130cellular response to unfolded protein (GO:0034620)2.46070818
131endothelial cell migration (GO:0043542)2.44642056
132angiogenesis involved in wound healing (GO:0060055)2.44458974
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44313912
134glycosaminoglycan catabolic process (GO:0006027)2.43254759
135trabecula formation (GO:0060343)2.42997326
136extracellular negative regulation of signal transduction (GO:1900116)2.42512934
137extracellular regulation of signal transduction (GO:1900115)2.42512934
138negative regulation of cartilage development (GO:0061037)2.42182504
139renal filtration (GO:0097205)2.41915064
140endothelium development (GO:0003158)2.41734576
141middle ear morphogenesis (GO:0042474)2.41625601
142sequestering of metal ion (GO:0051238)2.41622533
143chondrocyte development (GO:0002063)2.41354082
144type B pancreatic cell development (GO:0003323)2.41077114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse3.74585765
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.69969963
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.44007598
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.30068602
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.98744549
6CLOCK_20551151_ChIP-Seq_293T_Human2.94919755
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.84768289
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84517433
9* ELK3_25401928_ChIP-Seq_HUVEC_Human2.76797095
10* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.48970897
11VDR_21846776_ChIP-Seq_THP-1_Human2.48149936
12SCL_19346495_ChIP-Seq_HPC-7_Human2.46196695
13E2F7_22180533_ChIP-Seq_HELA_Human2.40563752
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.27385586
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.25585169
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.13202629
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13044535
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10605640
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06508700
20MYC_22102868_ChIP-Seq_BL_Human2.01421069
21VDR_24763502_ChIP-Seq_THP-1_Human2.00240528
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92584942
23DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.91662551
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91536636
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87062543
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82985243
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.78454612
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.76598044
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75156273
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73263172
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72673094
32* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72478371
33TCF7_22412390_ChIP-Seq_EML_Mouse1.71684571
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.70792750
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.70715300
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66561213
37BRD4_25478319_ChIP-Seq_HGPS_Human1.65791992
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64874160
39LXR_22292898_ChIP-Seq_THP-1_Human1.62174364
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59554506
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57946298
42* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.57761641
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57498735
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.57187802
45KDM2B_26808549_Chip-Seq_K562_Human1.57180633
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55511672
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55220615
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.52883062
49FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.52234005
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51497958
51* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50663192
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44861756
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44861756
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44789872
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44568942
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44300605
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42320994
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41020282
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40737397
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40525875
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40258919
62* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38779899
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38634066
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38597408
65KDM2B_26808549_Chip-Seq_DND41_Human1.38279191
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.38035070
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37595934
68SPI1_23127762_ChIP-Seq_K562_Human1.37435076
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37271569
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36763303
71NCOR1_26117541_ChIP-Seq_K562_Human1.36637964
72SA1_22415368_ChIP-Seq_MEFs_Mouse1.34921711
73* MAF_26560356_Chip-Seq_TH1_Human1.34309742
74SPI1_23547873_ChIP-Seq_NB4_Human1.34120940
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31705239
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.30903831
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29846104
78* UTX_26944678_Chip-Seq_JUKART_Human1.28431597
79TP53_23651856_ChIP-Seq_MEFs_Mouse1.28347076
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.27829658
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.27829658
82* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27542276
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26499033
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24975624
85MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24513373
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24460791
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24414023
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23836882
89TP53_22127205_ChIP-Seq_IMR90_Human1.23391681
90JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23189287
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23088775
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21421682
93* RACK7_27058665_Chip-Seq_MCF-7_Human1.20537793
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20522997
95CJUN_26792858_Chip-Seq_BT549_Human1.20343252
96* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19081313
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.18348964
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.18091673
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.17489613
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.17382806
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17315698
102TFEB_21752829_ChIP-Seq_HELA_Human1.17281917
103* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15749809
104* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15375300
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.14359331
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14233163
107* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14006583
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13757277
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11890845
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.11865560
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11599385
112ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11020333
113ATF3_27146783_Chip-Seq_COLON_Human1.10248585
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09807271
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09797165
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09212285
117GATA1_22025678_ChIP-Seq_K562_Human1.08867320
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08038394
119* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08006569
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07318351
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07304039
122ESR1_21235772_ChIP-Seq_MCF-7_Human1.07237963
123FOXM1_23109430_ChIP-Seq_U2OS_Human1.05981543
124CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04140023
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03818264
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03818264
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03579179
128* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03394630
129GATA1_19941826_ChIP-Seq_K562_Human1.03137658
130SA1_27219007_Chip-Seq_ERYTHROID_Human1.02884522
131RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02607701
132SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02544686
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01942802
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01858214
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01537586
136RNF2_27304074_Chip-Seq_ESCs_Mouse1.01349780
137TET1_21490601_ChIP-Seq_MESCs_Mouse1.01198033
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00765748
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00738852
140GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00416023
141* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00126181
142* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99064581
143* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98237688
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97656572
145JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97507328
146RXR_22158963_ChIP-Seq_LIVER_Mouse0.94762400
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93717328
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93717328
149NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93430388
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.93372586
151CTCF_27219007_Chip-Seq_Bcells_Human0.92470342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.00189369
2MP0005503_abnormal_tendon_morphology4.21603447
3MP0005275_abnormal_skin_tensile3.80347944
4MP0003279_aneurysm3.80287677
5MP0004272_abnormal_basement_membrane3.58542610
6MP0006054_spinal_hemorrhage3.55634644
7MP0003705_abnormal_hypodermis_morpholog3.44837603
8MP0010368_abnormal_lymphatic_system3.31197720
9MP0001958_emphysema2.67543851
10MP0001879_abnormal_lymphatic_vessel2.15753486
11MP0003566_abnormal_cell_adhesion1.89682207
12MP0005508_abnormal_skeleton_morphology1.86084921
13MP0004858_abnormal_nervous_system1.79646054
14MP0005623_abnormal_meninges_morphology1.79463502
15MP0000767_abnormal_smooth_muscle1.71920203
16MP0002877_abnormal_melanocyte_morpholog1.62319230
17MP0002933_joint_inflammation1.52986199
18MP0002060_abnormal_skin_morphology1.48031304
19MP0005257_abnormal_intraocular_pressure1.47487080
20MP0004808_abnormal_hematopoietic_stem1.46784650
21MP0003283_abnormal_digestive_organ1.46737078
22MP0009278_abnormal_bone_marrow1.45833151
23MP0003122_maternal_imprinting1.45498552
24MP0003300_gastrointestinal_ulcer1.43482267
25MP0002896_abnormal_bone_mineralization1.43439356
26MP0003385_abnormal_body_wall1.42084630
27MP0005023_abnormal_wound_healing1.41315148
28MP0009384_cardiac_valve_regurgitation1.33821766
29MP0005390_skeleton_phenotype1.33002517
30MP0009840_abnormal_foam_cell1.31964657
31MP0010030_abnormal_orbit_morphology1.31335781
32MP0002108_abnormal_muscle_morphology1.30702243
33MP0009250_abnormal_appendicular_skeleto1.30073034
34MP0002254_reproductive_system_inflammat1.20702903
35MP0002396_abnormal_hematopoietic_system1.20638301
36MP0000013_abnormal_adipose_tissue1.18710183
37MP0003942_abnormal_urinary_system1.17662523
38MP0004134_abnormal_chest_morphology1.16080383
39MP0002295_abnormal_pulmonary_circulatio1.14720298
40MP0002932_abnormal_joint_morphology1.13121288
41MP0000428_abnormal_craniofacial_morphol1.12983174
42MP0002128_abnormal_blood_circulation1.12218794
43MP0010352_gastrointestinal_tract_polyps1.12111274
44MP0002282_abnormal_trachea_morphology1.10040596
45MP0001299_abnormal_eye_distance/1.08974730
46MP0002115_abnormal_skeleton_extremities1.08256458
47MP0000465_gastrointestinal_hemorrhage1.07065147
48MP0001533_abnormal_skeleton_physiology1.06692802
49MP0003115_abnormal_respiratory_system1.05300020
50* MP0001243_abnormal_dermal_layer1.04640239
51MP0005171_absent_coat_pigmentation1.04449797
52MP0000163_abnormal_cartilage_morphology1.04387646
53MP0000733_abnormal_muscle_development1.03621015
54MP0005220_abnormal_exocrine_pancreas1.03248131
55MP0001348_abnormal_lacrimal_gland1.03039111
56MP0002113_abnormal_skeleton_development1.02542416
57MP0002998_abnormal_bone_remodeling1.02487787
58MP0001915_intracranial_hemorrhage1.01472254
59MP0003091_abnormal_cell_migration0.98331285
60MP0001542_abnormal_bone_strength0.96175595
61* MP0001614_abnormal_blood_vessel0.96057831
62MP0003303_peritoneal_inflammation0.95103970
63MP0003724_increased_susceptibility_to0.94367273
64MP0009053_abnormal_anal_canal0.94333725
65MP0003795_abnormal_bone_structure0.94167996
66MP0005164_abnormal_response_to0.94039836
67MP0000049_abnormal_middle_ear0.92846418
68MP0003123_paternal_imprinting0.92727933
69MP0004084_abnormal_cardiac_muscle0.91943571
70MP0003828_pulmonary_edema0.90868389
71MP0003567_abnormal_fetal_cardiomyocyte0.87846793
72MP0005058_abnormal_lysosome_morphology0.87642470
73MP0002925_abnormal_cardiovascular_devel0.85978914
74MP0000534_abnormal_ureter_morphology0.84890563
75MP0001270_distended_abdomen0.83272321
76MP0005076_abnormal_cell_differentiation0.82885469
77MP0000759_abnormal_skeletal_muscle0.82618862
78MP0003950_abnormal_plasma_membrane0.82183223
79MP0000343_altered_response_to0.81182573
80MP0001175_abnormal_lung_morphology0.81094833
81MP0010386_abnormal_urinary_bladder0.79540533
82MP0003935_abnormal_craniofacial_develop0.79014716
83MP0001545_abnormal_hematopoietic_system0.77854027
84MP0005397_hematopoietic_system_phenotyp0.77854027
85MP0002109_abnormal_limb_morphology0.77172721
86MP0003941_abnormal_skin_development0.76152450
87MP0005409_darkened_coat_color0.75713184
88MP0002089_abnormal_postnatal_growth/wei0.75567127
89MP0000003_abnormal_adipose_tissue0.74659157
90MP0004145_abnormal_muscle_electrophysio0.74180438
91MP0004510_myositis0.72445829
92MP0000249_abnormal_blood_vessel0.71571506
93MP0005464_abnormal_platelet_physiology0.71415233
94MP0010630_abnormal_cardiac_muscle0.69231288
95MP0000538_abnormal_urinary_bladder0.68662970
96MP0009780_abnormal_chondrocyte_physiolo0.68606474
97MP0002168_other_aberrant_phenotype0.67923577
98MP0002249_abnormal_larynx_morphology0.67464954
99MP0000266_abnormal_heart_morphology0.67407838
100MP0000432_abnormal_head_morphology0.67134974
101MP0000750_abnormal_muscle_regeneration0.67060207
102MP0005388_respiratory_system_phenotype0.66703365
103MP0002133_abnormal_respiratory_system0.66703365
104MP0005595_abnormal_vascular_smooth0.66665969
105MP0001849_ear_inflammation0.65295663
106MP0008004_abnormal_stomach_pH0.64149521
107MP0003329_amyloid_beta_deposits0.63783885
108MP0004197_abnormal_fetal_growth/weight/0.63709173
109MP0000604_amyloidosis0.62413211
110MP0002135_abnormal_kidney_morphology0.62400311
111MP0002116_abnormal_craniofacial_bone0.61980815
112MP0003436_decreased_susceptibility_to0.61952495
113MP0003172_abnormal_lysosome_physiology0.60847046
114MP0000858_altered_metastatic_potential0.59554747
115MP0004883_abnormal_blood_vessel0.59258668
116MP0002938_white_spotting0.58845228
117MP0000462_abnormal_digestive_system0.58210541
118MP0003448_altered_tumor_morphology0.57841491
119MP0006138_congestive_heart_failure0.57755330
120MP0005360_urolithiasis0.57279058
121MP0005197_abnormal_uvea_morphology0.56936926
122MP0000751_myopathy0.56589303
123MP0005369_muscle_phenotype0.56117386
124MP0001944_abnormal_pancreas_morphology0.56070410
125MP0002114_abnormal_axial_skeleton0.55873765
126MP0009333_abnormal_splenocyte_physiolog0.55788619
127MP0000762_abnormal_tongue_morphology0.55778417
128MP0003191_abnormal_cellular_cholesterol0.55218341
129MP0002419_abnormal_innate_immunity0.54236680
130MP0005165_increased_susceptibility_to0.54071864
131MP0000678_abnormal_parathyroid_gland0.53368770

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.44828301
2Premature rupture of membranes (HP:0001788)6.25202574
3Ankle contracture (HP:0006466)4.75582296
4Broad metatarsal (HP:0001783)4.68551923
5Shallow orbits (HP:0000586)4.45204353
6Cerebral aneurysm (HP:0004944)4.41574073
7Aortic dissection (HP:0002647)4.39783074
8Peritonitis (HP:0002586)4.20432493
9Wrist flexion contracture (HP:0001239)3.90549018
10Bladder diverticulum (HP:0000015)3.77853093
11Cervical subluxation (HP:0003308)3.76817347
12Soft skin (HP:0000977)3.72895215
13Aortic aneurysm (HP:0004942)3.30012252
14Atrophic scars (HP:0001075)3.28918999
15Nonimmune hydrops fetalis (HP:0001790)3.24296366
16Spinal rigidity (HP:0003306)3.14218173
17Fragile skin (HP:0001030)3.12249467
18Blue sclerae (HP:0000592)3.11168095
19Follicular hyperkeratosis (HP:0007502)3.08016900
20Biconcave vertebral bodies (HP:0004586)3.05578572
21Abnormality of dentin (HP:0010299)3.05319209
22Wormian bones (HP:0002645)3.04915996
23Mitral valve prolapse (HP:0001634)3.04165444
24Vertebral compression fractures (HP:0002953)3.02578706
25Dilatation of the ascending aorta (HP:0005111)3.01559768
26Thin bony cortex (HP:0002753)2.97566069
27Genu recurvatum (HP:0002816)2.95895724
28Type 1 muscle fiber predominance (HP:0003803)2.90791799
29Spondylolisthesis (HP:0003302)2.90003870
30Hypoventilation (HP:0002791)2.89136461
31Slender build (HP:0001533)2.82716779
32Ectopia lentis (HP:0001083)2.77989457
33Abnormality of the acetabulum (HP:0003170)2.74323134
34Bowel diverticulosis (HP:0005222)2.63682906
35Ulnar bowing (HP:0003031)2.63564215
36Aneurysm (HP:0002617)2.60194479
37Short 4th metacarpal (HP:0010044)2.58887848
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58887848
39Neonatal short-limb short stature (HP:0008921)2.57129934
40Abnormality of the peritoneum (HP:0002585)2.51024406
41Asymmetry of the thorax (HP:0001555)2.49954396
42Coxa vara (HP:0002812)2.43867218
43Radial bowing (HP:0002986)2.42026369
44Mild short stature (HP:0003502)2.36996986
45Overgrowth (HP:0001548)2.36176569
46Increased connective tissue (HP:0009025)2.32951129
47Disproportionate tall stature (HP:0001519)2.26682423
48Round ear (HP:0100830)2.26475162
49Deviation of the hallux (HP:0010051)2.23852865
50Lymphangioma (HP:0100764)2.20892766
51Platyspondyly (HP:0000926)2.19131206
52High pitched voice (HP:0001620)2.17206771
53Joint laxity (HP:0001388)2.17160291
54Slender long bone (HP:0003100)2.17060007
55Increased variability in muscle fiber diameter (HP:0003557)2.16389864
56Bowed forearm bones (HP:0003956)2.14568379
57Bowing of the arm (HP:0006488)2.14568379
58Distal upper limb amyotrophy (HP:0007149)2.12346848
59Upper limb amyotrophy (HP:0009129)2.12346848
60Achilles tendon contracture (HP:0001771)2.12125558
61Hallux valgus (HP:0001822)2.11969122
62Aortic valve stenosis (HP:0001650)2.10271108
63Abnormal delivery (HP:0001787)2.09514923
64Abnormality of the 4th metacarpal (HP:0010012)2.08889930
65Hyperextensible skin (HP:0000974)2.08624075
66Mitral regurgitation (HP:0001653)2.08084024
67Mesomelia (HP:0003027)2.06521864
68Broad ribs (HP:0000885)2.04828128
69Elbow flexion contracture (HP:0002987)2.02932564
70Protruding ear (HP:0000411)2.02814832
71Camptodactyly of toe (HP:0001836)2.02674258
72Flat cornea (HP:0007720)2.02516467
73Aortic regurgitation (HP:0001659)2.02319008
74Osteolytic defects of the hand bones (HP:0009699)2.01769094
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.01769094
76Joint contractures involving the joints of the feet (HP:0100492)2.01326081
77Flexion contracture of toe (HP:0005830)2.01326081
78Infantile muscular hypotonia (HP:0008947)2.01084426
79Vascular tortuosity (HP:0004948)2.00973050
80Hematochezia (HP:0002573)2.00954572
81Thoracolumbar scoliosis (HP:0002944)2.00402797
82Obstructive sleep apnea (HP:0002870)2.00254606
83Syringomyelia (HP:0003396)1.99727458
84Spinal cord lesions (HP:0100561)1.99727458
85Joint stiffness (HP:0001387)1.98643342
86Femoral bowing (HP:0002980)1.98551696
87Renal duplication (HP:0000075)1.98330855
88Mildly elevated creatine phosphokinase (HP:0008180)1.98120887
89Abnormality of skeletal muscle fiber size (HP:0012084)1.98078646
90Osteoarthritis (HP:0002758)1.97847239
91Spontaneous hematomas (HP:0007420)1.97806738
92Wide anterior fontanel (HP:0000260)1.96981177
93Tibial bowing (HP:0002982)1.96463421
94Turricephaly (HP:0000262)1.94962359
95Emphysema (HP:0002097)1.94906139
96Striae distensae (HP:0001065)1.93290181
97Abnormality of skull ossification (HP:0002703)1.92687920
98Stridor (HP:0010307)1.87714008
99Premature skin wrinkling (HP:0100678)1.87694140
100Abnormality of the Achilles tendon (HP:0005109)1.87657783
101Coronal craniosynostosis (HP:0004440)1.86096994
102Natal tooth (HP:0000695)1.83841950
103Decreased skull ossification (HP:0004331)1.81026017
104Generalized amyotrophy (HP:0003700)1.79749139
105Enlarged penis (HP:0000040)1.79711934
106Ovoid vertebral bodies (HP:0003300)1.79638997
107Hyperacusis (HP:0010780)1.78564469
108Long toe (HP:0010511)1.77338589
109Arterial tortuosity (HP:0005116)1.77277495
110Buphthalmos (HP:0000557)1.76995721
111Breech presentation (HP:0001623)1.76583411
112Venous insufficiency (HP:0005293)1.73738931
113Delayed cranial suture closure (HP:0000270)1.73041992
114Exostoses (HP:0100777)1.72286646
115Broad long bones (HP:0005622)1.72197460
116Hip contracture (HP:0003273)1.71077684
117Limb-girdle muscle weakness (HP:0003325)1.70965449
118Hand muscle atrophy (HP:0009130)1.70926679
119Venous abnormality (HP:0002624)1.70909472
120Hypoplasia of the iris (HP:0007676)1.69961865
121Dysostosis multiplex (HP:0000943)1.68193838
122Inguinal hernia (HP:0000023)1.68090886
123Urinary glycosaminoglycan excretion (HP:0003541)1.67963700
124Mucopolysacchariduria (HP:0008155)1.67963700
125Mitral stenosis (HP:0001718)1.66980158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.50683791
2TIE14.29044016
3PKN23.93509002
4ERN13.49506143
5SCYL23.00041947
6KDR2.88670075
7TTN2.82462688
8TGFBR22.79783288
9PDGFRA2.72890339
10DDR22.37429549
11FLT32.30616696
12NTRK12.20870083
13EEF2K2.14439965
14TGFBR12.10970208
15PTK62.05160690
16KIT2.01884590
17TESK11.98671827
18RIPK11.95587750
19CDC42BPA1.95465967
20MAP3K101.76727683
21PAK41.68410506
22MAP2K31.54470690
23SIK11.52118943
24PASK1.48727030
25LRRK21.38972390
26SMG11.37588098
27ICK1.37112203
28EPHA31.35892081
29TAOK31.35616763
30NME21.35422502
31EPHB21.34357565
32MYLK1.32095659
33LIMK11.31617753
34PRPF4B1.30442416
35MAP3K61.27281509
36MAP4K11.23837418
37EPHB11.23499358
38MOS1.22982296
39AKT31.22064754
40PAK21.17912599
41RPS6KA41.17811648
42NEK91.16608769
43JAK31.09192876
44PTK21.05711082
45LATS11.00987351
46MET0.98573352
47BTK0.97987441
48ILK0.97961891
49STK380.95631070
50ZAP700.95211867
51BLK0.95204134
52GRK70.95006015
53MAPK70.94408279
54TAOK20.93025681
55PDGFRB0.91369963
56LMTK20.89945216
57BMX0.87195262
58DMPK0.86793213
59TBK10.84271357
60PTK2B0.83799925
61DAPK30.83460787
62TRPM70.82607653
63INSRR0.81939655
64IRAK30.81910492
65STK30.77672704
66GRK50.75749746
67TEC0.75500629
68ROCK20.72231850
69NEK20.72107852
70MAP3K70.71745109
71CLK10.71402581
72ADRBK10.71366257
73CSF1R0.71228036
74FGFR40.70726510
75ERBB40.70132424
76MTOR0.68877270
77MARK20.67095598
78TYK20.67047857
79MAP3K130.66292509
80DYRK1B0.64781425
81PRKG20.59687400
82PIM20.59642514
83GSK3A0.57591219
84IRAK40.55946073
85PDPK10.55632229
86JAK10.55378072
87PRKD30.55103104
88CDK70.54679182
89PRKCH0.53959168
90MAPKAPK30.53315005
91HIPK20.52947139
92FER0.52421910
93CDK80.52219606
94CAMK1D0.52196324
95RPS6KC10.50942224
96RPS6KL10.50942224
97RPS6KA60.50273789
98MAPK40.48189888
99FGFR10.47373089
100MAP3K30.45896540
101PAK10.45613448
102MST1R0.44939226
103RPS6KA20.44811879
104RET0.44457490
105SIK20.42917621
106CAMKK20.42540166
107GRK60.41450633
108HCK0.41241857
109MAP3K10.41086391
110BRSK20.39367960
111CDK120.38571909
112RPS6KB20.38021096
113MKNK10.36991730
114PRKD10.36248728
115PAK60.35900903
116PIK3CG0.34872198
117EPHA20.34659217
118MAP3K80.34070135
119MAP3K110.33741016
120CAMK2G0.33379009
121CSK0.33197811
122STK40.33027378
123WNK10.32312848
124CHUK0.32217433
125IGF1R0.31847302
126MELK0.31079934
127MAP3K140.31029833
128MAP2K10.30393334
129ROCK10.30347213
130MAPKAPK20.30228206
131SRC0.29545709
132CDK60.29324055
133ABL20.29100238
134LATS20.27688134
135MAP2K20.27383726
136LYN0.27365705
137BCKDK0.27096261
138MAPKAPK50.26873693
139PRKD20.26305661
140MATK0.25948685

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.22783728
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.84463449
3Focal adhesion_Homo sapiens_hsa045102.63786479
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.59927996
5Other glycan degradation_Homo sapiens_hsa005112.34062201
6Protein digestion and absorption_Homo sapiens_hsa049742.20063828
7Amoebiasis_Homo sapiens_hsa051462.16497654
8Malaria_Homo sapiens_hsa051442.09678984
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05952539
10N-Glycan biosynthesis_Homo sapiens_hsa005102.00151262
11Small cell lung cancer_Homo sapiens_hsa052221.99870238
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.96673429
13Proteoglycans in cancer_Homo sapiens_hsa052051.68896045
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.66216840
15Chronic myeloid leukemia_Homo sapiens_hsa052201.65792479
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.65254030
17Platelet activation_Homo sapiens_hsa046111.61715933
18Leishmaniasis_Homo sapiens_hsa051401.60456472
19Protein export_Homo sapiens_hsa030601.60451042
20Lysosome_Homo sapiens_hsa041421.48468452
21Staphylococcus aureus infection_Homo sapiens_hsa051501.46592954
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.46218261
23Prion diseases_Homo sapiens_hsa050201.44018807
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.42247561
25Toxoplasmosis_Homo sapiens_hsa051451.34469741
26Bladder cancer_Homo sapiens_hsa052191.24137889
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.23073318
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21037019
29Pertussis_Homo sapiens_hsa051331.20972513
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18463390
31Complement and coagulation cascades_Homo sapiens_hsa046101.17435820
32Dilated cardiomyopathy_Homo sapiens_hsa054141.16687861
33Adherens junction_Homo sapiens_hsa045201.14726642
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14582719
35DNA replication_Homo sapiens_hsa030301.07302825
36MicroRNAs in cancer_Homo sapiens_hsa052061.03935383
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.03722253
38Legionellosis_Homo sapiens_hsa051341.03371083
39Shigellosis_Homo sapiens_hsa051311.01503837
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98485649
41Hepatitis B_Homo sapiens_hsa051610.97833413
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.96586100
43Viral myocarditis_Homo sapiens_hsa054160.96387203
44Pancreatic cancer_Homo sapiens_hsa052120.96306150
45Notch signaling pathway_Homo sapiens_hsa043300.96256727
46Pathways in cancer_Homo sapiens_hsa052000.95184319
47Osteoclast differentiation_Homo sapiens_hsa043800.95006445
48Phagosome_Homo sapiens_hsa041450.94900456
49Lysine degradation_Homo sapiens_hsa003100.93055455
50TGF-beta signaling pathway_Homo sapiens_hsa043500.92761284
51HTLV-I infection_Homo sapiens_hsa051660.92615258
52Renin-angiotensin system_Homo sapiens_hsa046140.90145410
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89221874
54Insulin resistance_Homo sapiens_hsa049310.88277839
55Basal cell carcinoma_Homo sapiens_hsa052170.86338505
56Galactose metabolism_Homo sapiens_hsa000520.85747412
57Gap junction_Homo sapiens_hsa045400.84879889
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83841988
59Prostate cancer_Homo sapiens_hsa052150.82400388
60Antigen processing and presentation_Homo sapiens_hsa046120.82340506
61TNF signaling pathway_Homo sapiens_hsa046680.82186712
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81967179
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80750335
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80593758
65Melanogenesis_Homo sapiens_hsa049160.80489335
66Acute myeloid leukemia_Homo sapiens_hsa052210.80048022
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80020934
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79971553
69GnRH signaling pathway_Homo sapiens_hsa049120.78436460
70p53 signaling pathway_Homo sapiens_hsa041150.77361676
71Vibrio cholerae infection_Homo sapiens_hsa051100.76261085
72Apoptosis_Homo sapiens_hsa042100.74689718
73Melanoma_Homo sapiens_hsa052180.72472691
74Estrogen signaling pathway_Homo sapiens_hsa049150.71304070
75Cell cycle_Homo sapiens_hsa041100.70089502
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.69822602
77Axon guidance_Homo sapiens_hsa043600.68912787
78Hematopoietic cell lineage_Homo sapiens_hsa046400.68711990
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68627243
80Base excision repair_Homo sapiens_hsa034100.68573330
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68546498
82Hedgehog signaling pathway_Homo sapiens_hsa043400.67719544
83Measles_Homo sapiens_hsa051620.67644047
84Viral carcinogenesis_Homo sapiens_hsa052030.67190897
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65296893
86Sulfur metabolism_Homo sapiens_hsa009200.64763272
87Salmonella infection_Homo sapiens_hsa051320.64209665
88Rap1 signaling pathway_Homo sapiens_hsa040150.63745730
89Endocytosis_Homo sapiens_hsa041440.62499466
90Selenocompound metabolism_Homo sapiens_hsa004500.61576207
91Starch and sucrose metabolism_Homo sapiens_hsa005000.61204883
92Herpes simplex infection_Homo sapiens_hsa051680.60959614
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60679854
94Tuberculosis_Homo sapiens_hsa051520.59733788
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.59054629
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58983253
97Thyroid cancer_Homo sapiens_hsa052160.58290924
98Caffeine metabolism_Homo sapiens_hsa002320.57257272
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56491847
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56064192
101PPAR signaling pathway_Homo sapiens_hsa033200.55163648
102Prolactin signaling pathway_Homo sapiens_hsa049170.54188911
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.54154063
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54144894
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53912714
106Tight junction_Homo sapiens_hsa045300.52706706
107Fructose and mannose metabolism_Homo sapiens_hsa000510.51894503
108Renal cell carcinoma_Homo sapiens_hsa052110.49642063
109Non-small cell lung cancer_Homo sapiens_hsa052230.49435644
110HIF-1 signaling pathway_Homo sapiens_hsa040660.49241852
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.48992013
112mTOR signaling pathway_Homo sapiens_hsa041500.48720323
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.48575106
114Ovarian steroidogenesis_Homo sapiens_hsa049130.46975115
115Hepatitis C_Homo sapiens_hsa051600.46259234
116Ras signaling pathway_Homo sapiens_hsa040140.46224486
117Cocaine addiction_Homo sapiens_hsa050300.46179536
118Hippo signaling pathway_Homo sapiens_hsa043900.46038152
119One carbon pool by folate_Homo sapiens_hsa006700.46007411
120Endometrial cancer_Homo sapiens_hsa052130.45336429
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44983144
122Thyroid hormone synthesis_Homo sapiens_hsa049180.44940508
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.44705039
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43982333
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43567797
126MAPK signaling pathway_Homo sapiens_hsa040100.42533434
127AMPK signaling pathway_Homo sapiens_hsa041520.41290439
128Renin secretion_Homo sapiens_hsa049240.41149588
129Arachidonic acid metabolism_Homo sapiens_hsa005900.38404852
130VEGF signaling pathway_Homo sapiens_hsa043700.37812266
131Colorectal cancer_Homo sapiens_hsa052100.35663505
132Glioma_Homo sapiens_hsa052140.35626621
133Ribosome_Homo sapiens_hsa030100.34810039
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34572757

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