EMC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.76831521
2proteasome assembly (GO:0043248)4.59160345
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.52661182
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.51722196
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.45418654
6regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.15493351
7negative regulation of ligase activity (GO:0051352)4.12819424
8negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.12819424
9ribosomal small subunit biogenesis (GO:0042274)4.10521811
10mitotic metaphase plate congression (GO:0007080)4.10498669
11anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.09039849
12positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.06994958
13respiratory electron transport chain (GO:0022904)4.05312205
14kinetochore assembly (GO:0051382)3.98820907
15electron transport chain (GO:0022900)3.97064590
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94543330
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84088498
18ATP synthesis coupled proton transport (GO:0015986)3.84088498
19kinetochore organization (GO:0051383)3.82128586
20rRNA modification (GO:0000154)3.80116173
21GDP-mannose metabolic process (GO:0019673)3.75247514
22protein targeting to mitochondrion (GO:0006626)3.74322171
23pseudouridine synthesis (GO:0001522)3.66106421
24ribosomal small subunit assembly (GO:0000028)3.63405485
25ribosomal large subunit biogenesis (GO:0042273)3.61382533
26establishment of protein localization to mitochondrion (GO:0072655)3.60643452
27viral transcription (GO:0019083)3.59346313
28positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.56970688
29regulation of cellular amino acid metabolic process (GO:0006521)3.56487062
30metaphase plate congression (GO:0051310)3.55732917
31mitotic sister chromatid segregation (GO:0000070)3.54097716
32negative regulation of dendrite morphogenesis (GO:0050774)3.50633585
33protein localization to mitochondrion (GO:0070585)3.49614816
34translational termination (GO:0006415)3.49023261
35cullin deneddylation (GO:0010388)3.48308722
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.47568442
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.46755317
38CENP-A containing nucleosome assembly (GO:0034080)3.44333812
39cotranslational protein targeting to membrane (GO:0006613)3.42877030
40protein targeting to ER (GO:0045047)3.42232515
41positive regulation of ligase activity (GO:0051351)3.41544678
42chromatin remodeling at centromere (GO:0031055)3.40727473
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.40427222
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.40142966
45signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.40142966
46signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.40142966
47intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.39025752
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.39025752
49translation (GO:0006412)3.36572430
50establishment of viral latency (GO:0019043)3.35836832
51establishment of integrated proviral latency (GO:0075713)3.35611999
52protein deneddylation (GO:0000338)3.34962769
53regulation of ubiquitin-protein transferase activity (GO:0051438)3.34943058
54spliceosomal snRNP assembly (GO:0000387)3.34468797
55signal transduction involved in DNA damage checkpoint (GO:0072422)3.33296620
56signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33296620
57peptidyl-histidine modification (GO:0018202)3.31203774
58transcription from mitochondrial promoter (GO:0006390)3.30710573
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.30451920
60respiratory chain complex IV assembly (GO:0008535)3.27338150
61chaperone-mediated protein transport (GO:0072321)3.26321961
62protein localization to endoplasmic reticulum (GO:0070972)3.26103336
63protein complex biogenesis (GO:0070271)3.23393718
64translational elongation (GO:0006414)3.23249157
65regulation of ligase activity (GO:0051340)3.22853070
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22399657
67regulation of mitotic spindle checkpoint (GO:1903504)3.19956310
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19956310
69protein localization to chromosome, centromeric region (GO:0071459)3.17745883
70dopamine transport (GO:0015872)3.17196158
71synaptic vesicle exocytosis (GO:0016079)3.15804929
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.15000682
73termination of RNA polymerase III transcription (GO:0006386)3.15000682
74protein localization to kinetochore (GO:0034501)3.14979705
75cellular component biogenesis (GO:0044085)3.14017291
76NADH metabolic process (GO:0006734)3.13615036
77iron-sulfur cluster assembly (GO:0016226)3.11396613
78metallo-sulfur cluster assembly (GO:0031163)3.11396613
79maturation of SSU-rRNA (GO:0030490)3.10937354
80regulation of spindle organization (GO:0090224)3.10756371
81sister chromatid segregation (GO:0000819)3.10308539
82DNA damage response, detection of DNA damage (GO:0042769)3.09320826
83succinate metabolic process (GO:0006105)3.07746270
84pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.07385024
85formation of translation preinitiation complex (GO:0001731)3.07344403
86spindle checkpoint (GO:0031577)3.06679884
87mitochondrial respiratory chain complex assembly (GO:0033108)3.04964725
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04168861
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02970166
90base-excision repair, AP site formation (GO:0006285)3.02297268
91negative regulation of sister chromatid segregation (GO:0033046)3.00427111
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00427111
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00427111
94negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00427111
95negative regulation of mitotic sister chromatid separation (GO:2000816)3.00427111
96negative regulation of chromosome segregation (GO:0051985)3.00181753
97nucleobase-containing small molecule interconversion (GO:0015949)2.99019905
98telomere maintenance via semi-conservative replication (GO:0032201)2.98826898
99translational initiation (GO:0006413)2.97856319
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92936083
101peroxisome fission (GO:0016559)2.91346729
102regulation of cell communication by electrical coupling (GO:0010649)2.89114340
103ATP hydrolysis coupled proton transport (GO:0015991)2.85400962
104energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.85400962
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83309794
106mitochondrial respiratory chain complex I assembly (GO:0032981)2.83309794
107NADH dehydrogenase complex assembly (GO:0010257)2.83309794
108negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82876750
109oxidative phosphorylation (GO:0006119)2.80773042
110regulation of short-term neuronal synaptic plasticity (GO:0048172)2.79653012
111regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.77005735
112neuronal action potential propagation (GO:0019227)2.76825455
113neurofilament cytoskeleton organization (GO:0060052)2.75818017
114calcium-mediated signaling using intracellular calcium source (GO:0035584)2.73474811
115regulation of relaxation of muscle (GO:1901077)2.72766914
116oxaloacetate metabolic process (GO:0006107)2.71892739
117regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.71183812
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70532360
119positive regulation of mitochondrial fission (GO:0090141)2.70029359
120tricarboxylic acid cycle (GO:0006099)2.67906194
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.66353786
122L-phenylalanine catabolic process (GO:0006559)2.66353786
123hydrogen ion transmembrane transport (GO:1902600)2.64164187
124negative regulation of dendrite development (GO:2000171)2.63860392
125regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.63299704
126neuron cell-cell adhesion (GO:0007158)2.61223468
127behavioral response to nicotine (GO:0035095)2.58978816
128regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.58936998
129transferrin transport (GO:0033572)2.57525334
130L-phenylalanine metabolic process (GO:0006558)2.57166926
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.57166926
132coenzyme catabolic process (GO:0009109)2.56459019
133fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.55578217
134glutamate secretion (GO:0014047)2.55411191
135regulation of glutamate secretion (GO:0014048)2.55378125
136inner mitochondrial membrane organization (GO:0007007)2.53613187
137regulation of synaptic vesicle transport (GO:1902803)2.52026863
138female mating behavior (GO:0060180)2.51786938
139neurotransmitter secretion (GO:0007269)2.50947243
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49431242
141catecholamine transport (GO:0051937)2.47825511
142regulation of mitochondrial translation (GO:0070129)2.44220514
143ATP biosynthetic process (GO:0006754)2.43807342
144regulation of synaptic vesicle exocytosis (GO:2000300)2.42900573
145trivalent inorganic cation transport (GO:0072512)2.42174869
146ferric iron transport (GO:0015682)2.42174869
147membrane depolarization during action potential (GO:0086010)2.42155394
148proton transport (GO:0015992)2.41756524
149regulation of oxidative phosphorylation (GO:0002082)2.41342482
150vocalization behavior (GO:0071625)2.40699613
151hydrogen transport (GO:0006818)2.40042888
152positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.38980050
153cofactor catabolic process (GO:0051187)2.38179350
154neuronal action potential (GO:0019228)2.35338514
155cytochrome complex assembly (GO:0017004)2.33716399
156aromatic amino acid family catabolic process (GO:0009074)2.33160551
157positive regulation of cellular amide metabolic process (GO:0034250)2.32750148
158regulation of cholesterol esterification (GO:0010872)2.32209639
159NAD metabolic process (GO:0019674)2.31601615
160phagosome maturation (GO:0090382)2.29434985
161detection of calcium ion (GO:0005513)2.28966189
162neurotransmitter-gated ion channel clustering (GO:0072578)2.27926533
163regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.26379899
164cellular ketone body metabolic process (GO:0046950)2.24209925
165aggressive behavior (GO:0002118)2.23802895
166protein-cofactor linkage (GO:0018065)2.22979625
167regulation of action potential (GO:0098900)2.21523034
168positive regulation of amino acid transport (GO:0051957)2.20957679
169regulation of amino acid transport (GO:0051955)2.20783770
170regulation of sequestering of triglyceride (GO:0010889)2.19992524
171positive regulation of potassium ion transmembrane transport (GO:1901381)2.19612832
172branched-chain amino acid catabolic process (GO:0009083)2.19065765
173neuromuscular process controlling posture (GO:0050884)2.18364734
174purine nucleoside triphosphate biosynthetic process (GO:0009145)2.17535151
175cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.16387458
176triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.16084445
177high-density lipoprotein particle remodeling (GO:0034375)2.15366147
178indole-containing compound catabolic process (GO:0042436)2.15363678
179indolalkylamine catabolic process (GO:0046218)2.15363678
180tryptophan catabolic process (GO:0006569)2.15363678
181alkaloid metabolic process (GO:0009820)2.15273245
182protein localization to synapse (GO:0035418)2.14453829
183aerobic respiration (GO:0009060)2.14240584
184neuron-neuron synaptic transmission (GO:0007270)2.14211701
185purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.13860710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43602275
2GBX2_23144817_ChIP-Seq_PC3_Human3.87940055
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73856965
4EZH2_22144423_ChIP-Seq_EOC_Human3.65356506
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.63732717
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.55834665
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.51657368
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.50234812
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.41718741
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34642173
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29975722
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.26233352
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19340036
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06665680
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04338252
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00118605
17E2F7_22180533_ChIP-Seq_HELA_Human2.98027128
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82692439
19TAF15_26573619_Chip-Seq_HEK293_Human2.74797732
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.70537988
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62411330
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61677142
23XRN2_22483619_ChIP-Seq_HELA_Human2.56673418
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56628471
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44153874
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.40985365
27DCP1A_22483619_ChIP-Seq_HELA_Human2.39353680
28GABP_19822575_ChIP-Seq_HepG2_Human2.33611164
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31809081
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30585442
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25977219
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24751395
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21321104
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.17999817
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13458403
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12191592
37FOXP3_21729870_ChIP-Seq_TREG_Human2.11220795
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10617790
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.07404215
40VDR_23849224_ChIP-Seq_CD4+_Human2.05299595
41REST_21632747_ChIP-Seq_MESCs_Mouse2.05272406
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.04826307
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04387988
44VDR_22108803_ChIP-Seq_LS180_Human1.99036528
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.94823673
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94316055
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86007833
48TTF2_22483619_ChIP-Seq_HELA_Human1.85679116
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.82914094
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.82697909
51P300_19829295_ChIP-Seq_ESCs_Human1.82569513
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80744686
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80711433
54IGF1R_20145208_ChIP-Seq_DFB_Human1.79508668
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77287013
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76049265
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75478705
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73983384
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71805879
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70707942
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68674030
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66860063
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66509216
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.63061460
65ELK1_19687146_ChIP-ChIP_HELA_Human1.62760364
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62528152
67SMAD4_21799915_ChIP-Seq_A2780_Human1.61832809
68ZNF263_19887448_ChIP-Seq_K562_Human1.60672231
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60545287
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60251951
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56504706
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.54899085
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54382045
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51885389
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50937089
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49384857
77* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49360497
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49165308
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.49098606
80KDM5A_27292631_Chip-Seq_BREAST_Human1.48706829
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47278174
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46986831
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46986831
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45232915
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44165647
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43623682
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43032032
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.42858718
89HTT_18923047_ChIP-ChIP_STHdh_Human1.42553547
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41560785
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.40533019
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39725364
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36103869
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33921328
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33050261
96AR_21909140_ChIP-Seq_LNCAP_Human1.32760628
97AR_25329375_ChIP-Seq_VCAP_Human1.30864096
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30419779
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28491218
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28405379
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28265743
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28017301
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27767223
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.27600501
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26928901
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25653510
107BCAT_22108803_ChIP-Seq_LS180_Human1.25463167
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.25131877
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.24460126
110MYC_18940864_ChIP-ChIP_HL60_Human1.23100416
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20914210
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20313085
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20053511
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19014223
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18730721
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17780185
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17025036
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16539486
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15503210
120SRF_21415370_ChIP-Seq_HL-1_Mouse1.14297425
121SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14194779
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13533898
123FOXP1_21924763_ChIP-Seq_HESCs_Human1.13286659
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.12203050
125CIITA_25753668_ChIP-Seq_RAJI_Human1.11809185
126ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11629767
127LXR_22158963_ChIP-Seq_LIVER_Mouse1.09738640
128NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07978893
129CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07623256
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06827908
131JUN_21703547_ChIP-Seq_K562_Human1.06502823
132TET1_21451524_ChIP-Seq_MESCs_Mouse1.05976576
133ER_23166858_ChIP-Seq_MCF-7_Human1.05954472
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04491328
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01979695
136RNF2_27304074_Chip-Seq_ESCs_Mouse1.01287177
137SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01201455
138PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00336561
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00202706
140KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00124413
141KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98160503
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98093998
143DROSHA_22980978_ChIP-Seq_HELA_Human0.96674635
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96586552
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95708554
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.95634959
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95268395
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95224809
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94951964
150TFEB_21752829_ChIP-Seq_HELA_Human0.94240871
151HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94203788
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.94173844
153HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94079631
154STAT3_23295773_ChIP-Seq_U87_Human0.94042528
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94037441
156AR_21572438_ChIP-Seq_LNCaP_Human0.93896569
157KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93770630
158P53_22387025_ChIP-Seq_ESCs_Mouse0.93574017
159STAT3_18555785_Chip-Seq_ESCs_Mouse0.93251534
160SOX2_19829295_ChIP-Seq_ESCs_Human0.92874545
161NANOG_19829295_ChIP-Seq_ESCs_Human0.92874545
162EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92468558
163RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91829598
164SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91551312
165NFE2_27457419_Chip-Seq_LIVER_Mouse0.91150964
166PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90918420
167KDM2B_26808549_Chip-Seq_REH_Human0.90897146
168SMAD_19615063_ChIP-ChIP_OVARY_Human0.90701468
169CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90361537
170PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90289376
171E2F1_18555785_Chip-Seq_ESCs_Mouse0.90284460
172SOX2_21211035_ChIP-Seq_LN229_Gbm0.90244568
173TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89917443
174MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89349441
175PRDM14_20953172_ChIP-Seq_ESCs_Human0.89214683
176RUNX2_22187159_ChIP-Seq_PCA_Human0.89187212
177SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88646329
178TAL1_26923725_Chip-Seq_HPCs_Mouse0.88269867
179MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88155560
180VDR_21846776_ChIP-Seq_THP-1_Human0.87990507
181NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87234226
182TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87054175
183PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87030241
184SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86805024
185CBX2_27304074_Chip-Seq_ESCs_Mouse0.86371134
186MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86224311
187STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84576033
188CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84188454
189OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81479476
190POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79454860
191ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78854788
192SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78485150
193ELF1_20517297_ChIP-Seq_JURKAT_Human0.77675850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.46092315
2MP0003111_abnormal_nucleus_morphology4.01069536
3MP0010094_abnormal_chromosome_stability3.59931224
4MP0008058_abnormal_DNA_repair3.39670913
5MP0002735_abnormal_chemical_nociception3.30196990
6MP0003077_abnormal_cell_cycle3.28523140
7MP0005451_abnormal_body_composition3.24246475
8MP0003880_abnormal_central_pattern3.20847359
9MP0006276_abnormal_autonomic_nervous3.20637215
10MP0003011_delayed_dark_adaptation3.16416633
11MP0004957_abnormal_blastocyst_morpholog3.09825837
12MP0001968_abnormal_touch/_nociception2.98930662
13MP0002139_abnormal_hepatobiliary_system2.94954901
14MP0002736_abnormal_nociception_after2.92447589
15MP0002837_dystrophic_cardiac_calcinosis2.79147352
16MP0008007_abnormal_cellular_replicative2.59108497
17MP0002876_abnormal_thyroid_physiology2.58123368
18MP0008932_abnormal_embryonic_tissue2.47205766
19MP0002822_catalepsy2.45486549
20MP0005085_abnormal_gallbladder_physiolo2.32388094
21MP0003646_muscle_fatigue2.23787285
22MP0005365_abnormal_bile_salt2.13305113
23MP0009745_abnormal_behavioral_response2.08974662
24MP0010030_abnormal_orbit_morphology2.06911837
25MP0009046_muscle_twitch2.05254291
26MP0004859_abnormal_synaptic_plasticity2.04478310
27MP0003123_paternal_imprinting2.04112295
28MP0002734_abnormal_mechanical_nocicepti1.99395512
29MP0003635_abnormal_synaptic_transmissio1.99233813
30MP0001346_abnormal_lacrimal_gland1.95096623
31MP0005360_urolithiasis1.94797800
32MP0002638_abnormal_pupillary_reflex1.93004372
33MP0002272_abnormal_nervous_system1.90743428
34MP0001501_abnormal_sleep_pattern1.90486461
35MP0002064_seizures1.90228747
36MP0001986_abnormal_taste_sensitivity1.88609640
37MP0001529_abnormal_vocalization1.86865736
38MP0004147_increased_porphyrin_level1.85949594
39MP0003786_premature_aging1.84427297
40MP0001188_hyperpigmentation1.83265949
41MP0003136_yellow_coat_color1.82898770
42MP0008875_abnormal_xenobiotic_pharmacok1.77682478
43MP0001984_abnormal_olfaction1.76776442
44MP0005083_abnormal_biliary_tract1.75045643
45MP0002938_white_spotting1.73265791
46MP0009697_abnormal_copulation1.73200109
47MP0002733_abnormal_thermal_nociception1.67558290
48MP0002163_abnormal_gland_morphology1.66297883
49MP0004270_analgesia1.65211768
50MP0003718_maternal_effect1.64388615
51MP0006036_abnormal_mitochondrial_physio1.63584130
52MP0002277_abnormal_respiratory_mucosa1.63420035
53MP0001970_abnormal_pain_threshold1.62867657
54MP0003315_abnormal_perineum_morphology1.60910895
55MP0004215_abnormal_myocardial_fiber1.60891949
56MP0002067_abnormal_sensory_capabilities1.59817851
57MP0000358_abnormal_cell_content/1.59662490
58MP0002572_abnormal_emotion/affect_behav1.59075128
59MP0001440_abnormal_grooming_behavior1.57182263
60MP0002063_abnormal_learning/memory/cond1.57146898
61MP0004142_abnormal_muscle_tone1.56323576
62MP0010386_abnormal_urinary_bladder1.55618817
63MP0001905_abnormal_dopamine_level1.55512788
64MP0005535_abnormal_body_temperature1.55487931
65MP0003656_abnormal_erythrocyte_physiolo1.54652754
66MP0005646_abnormal_pituitary_gland1.53267639
67MP0004924_abnormal_behavior1.52806791
68MP0005386_behavior/neurological_phenoty1.52806791
69MP0001661_extended_life_span1.50110142
70MP0000749_muscle_degeneration1.44942424
71MP0002102_abnormal_ear_morphology1.42648611
72MP0001730_embryonic_growth_arrest1.42592488
73MP0000751_myopathy1.42513297
74MP0002160_abnormal_reproductive_system1.40698600
75MP0006035_abnormal_mitochondrial_morpho1.39986705
76MP0005645_abnormal_hypothalamus_physiol1.39387690
77MP0009840_abnormal_foam_cell1.36569872
78MP0000313_abnormal_cell_death1.31944751
79MP0003183_abnormal_peptide_metabolism1.31618086
80MP0010329_abnormal_lipoprotein_level1.30821602
81MP0006292_abnormal_olfactory_placode1.29246265
82MP0002254_reproductive_system_inflammat1.25401120
83MP0001486_abnormal_startle_reflex1.24439244
84MP0005670_abnormal_white_adipose1.23659020
85MP0008789_abnormal_olfactory_epithelium1.23426007
86MP0001502_abnormal_circadian_rhythm1.23207667
87MP0008872_abnormal_physiological_respon1.20654890
88MP0002132_abnormal_respiratory_system1.19742596
89MP0008260_abnormal_autophagy1.18861585
90MP0003195_calcinosis1.18711852
91MP0004133_heterotaxia1.17817006
92MP0009333_abnormal_splenocyte_physiolog1.16961033
93MP0001727_abnormal_embryo_implantation1.16769793
94MP0004036_abnormal_muscle_relaxation1.16540302
95MP0001764_abnormal_homeostasis1.16063345
96MP0008877_abnormal_DNA_methylation1.15242426
97MP0004858_abnormal_nervous_system1.13042814
98MP0000350_abnormal_cell_proliferation1.12427168
99MP0005394_taste/olfaction_phenotype1.11967751
100MP0005499_abnormal_olfactory_system1.11967751
101MP0004130_abnormal_muscle_cell1.10760282
102MP0005332_abnormal_amino_acid1.10650408
103MP0002184_abnormal_innervation1.09401357
104MP0001929_abnormal_gametogenesis1.08707220
105MP0002210_abnormal_sex_determination1.06829613
106MP0002332_abnormal_exercise_endurance1.01810604
107MP0004782_abnormal_surfactant_physiolog1.01645177
108MP0001919_abnormal_reproductive_system1.01134467
109MP0002080_prenatal_lethality0.98783410
110MP0001697_abnormal_embryo_size0.97782570
111MP0002653_abnormal_ependyma_morphology0.97632514
112MP0001293_anophthalmia0.97592397
113MP0008775_abnormal_heart_ventricle0.97382958
114MP0003806_abnormal_nucleotide_metabolis0.97256555
115MP0001145_abnormal_male_reproductive0.96273803
116MP0005584_abnormal_enzyme/coenzyme_acti0.95168734
117MP0002557_abnormal_social/conspecific_i0.94984160
118MP0000750_abnormal_muscle_regeneration0.94978203
119MP0005084_abnormal_gallbladder_morpholo0.94857462
120MP0002118_abnormal_lipid_homeostasis0.92641343
121MP0004510_myositis0.91174161
122MP0005379_endocrine/exocrine_gland_phen0.90368013
123MP0004233_abnormal_muscle_weight0.89763471
124MP0005410_abnormal_fertilization0.88926789
125MP0000230_abnormal_systemic_arterial0.88532906
126MP0004484_altered_response_of0.86565614
127MP0005389_reproductive_system_phenotype0.86426424
128MP0003879_abnormal_hair_cell0.85953847
129MP0004085_abnormal_heartbeat0.85630386
130MP0008874_decreased_physiological_sensi0.85533416
131MP0005501_abnormal_skin_physiology0.85329839
132MP0008569_lethality_at_weaning0.84630311
133MP0003633_abnormal_nervous_system0.84251917
134MP0002972_abnormal_cardiac_muscle0.83949689
135MP0000653_abnormal_sex_gland0.83861554
136MP0000538_abnormal_urinary_bladder0.83457852
137MP0005448_abnormal_energy_balance0.83163859
138MP0000372_irregular_coat_pigmentation0.82293703
139MP0003186_abnormal_redox_activity0.80242209
140MP0005330_cardiomyopathy0.79760169
141MP0002229_neurodegeneration0.79383661
142MP0009764_decreased_sensitivity_to0.79102713
143MP0002090_abnormal_vision0.78904727
144MP0002078_abnormal_glucose_homeostasis0.77816732
145MP0003329_amyloid_beta_deposits0.77711803
146MP0002909_abnormal_adrenal_gland0.77671481
147MP0005551_abnormal_eye_electrophysiolog0.77377123
148MP0002019_abnormal_tumor_incidence0.77351198
149MP0005266_abnormal_metabolism0.76933094
150MP0003698_abnormal_male_reproductive0.76376994
151MP0003137_abnormal_impulse_conducting0.75629329
152MP0002066_abnormal_motor_capabilities/c0.75157298
153MP0005620_abnormal_muscle_contractility0.75062841
154MP0001853_heart_inflammation0.74894397
155MP0001672_abnormal_embryogenesis/_devel0.74311873
156MP0005380_embryogenesis_phenotype0.74311873
157MP0005423_abnormal_somatic_nervous0.74260686
158MP0005319_abnormal_enzyme/_coenzyme0.74238709
159MP0000049_abnormal_middle_ear0.73302610
160MP0001119_abnormal_female_reproductive0.70585650
161MP0002085_abnormal_embryonic_tissue0.68935509
162MP0009672_abnormal_birth_weight0.66839849
163MP0002161_abnormal_fertility/fecundity0.64673207
164MP0003121_genomic_imprinting0.64424580
165MP0006072_abnormal_retinal_apoptosis0.63940392
166MP0008995_early_reproductive_senescence0.62185736
167MP0005636_abnormal_mineral_homeostasis0.60014885
168MP0002111_abnormal_tail_morphology0.59074813
169MP0005384_cellular_phenotype0.55334705
170MP0009379_abnormal_foot_pigmentation0.53654214
171MP0001324_abnormal_eye_pigmentation0.52888952
172MP0005253_abnormal_eye_physiology0.52878361
173MP0000490_abnormal_crypts_of0.52457091
174MP0002269_muscular_atrophy0.50863317

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.90052580
2Abnormal mitochondria in muscle tissue (HP:0008316)4.66267263
3Acute encephalopathy (HP:0006846)4.28431606
4Mitochondrial inheritance (HP:0001427)4.24676647
5Progressive macrocephaly (HP:0004481)4.21925469
6Focal motor seizures (HP:0011153)4.08989475
7Hepatocellular necrosis (HP:0001404)3.95031543
8Hypothermia (HP:0002045)3.93841807
9Febrile seizures (HP:0002373)3.93495483
10Hepatic necrosis (HP:0002605)3.86692409
11Increased CSF lactate (HP:0002490)3.76459426
12Cerebral edema (HP:0002181)3.66205280
13Type I transferrin isoform profile (HP:0003642)3.52585305
14Pheochromocytoma (HP:0002666)3.31423279
15Myokymia (HP:0002411)3.30571757
16Neuroendocrine neoplasm (HP:0100634)3.30334979
17Lactic acidosis (HP:0003128)3.24139547
18Reduced antithrombin III activity (HP:0001976)3.21794670
19Atonic seizures (HP:0010819)3.16330192
20Aplasia/Hypoplasia of the sacrum (HP:0008517)3.05197146
21Microvesicular hepatic steatosis (HP:0001414)3.03319945
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92996082
23Abnormal protein N-linked glycosylation (HP:0012347)2.92996082
24Abnormal protein glycosylation (HP:0012346)2.92996082
25Abnormal glycosylation (HP:0012345)2.92996082
26Reticulocytopenia (HP:0001896)2.89992094
27Optic disc pallor (HP:0000543)2.77653470
28Abnormal number of erythroid precursors (HP:0012131)2.76080564
29Palpitations (HP:0001962)2.76052610
30Abnormality of aromatic amino acid family metabolism (HP:0004338)2.75795446
31Epileptic encephalopathy (HP:0200134)2.70866035
32Oligomenorrhea (HP:0000876)2.65418780
33Exercise intolerance (HP:0003546)2.64312433
34Hypoplastic pelvis (HP:0008839)2.62858697
35Abnormality of cells of the erythroid lineage (HP:0012130)2.62858630
36Testicular atrophy (HP:0000029)2.60113780
37Respiratory difficulties (HP:0002880)2.60004184
38Lipid accumulation in hepatocytes (HP:0006561)2.59252342
39Increased serum lactate (HP:0002151)2.58838478
40Meckel diverticulum (HP:0002245)2.54865350
41Increased muscle lipid content (HP:0009058)2.50118879
42Respiratory failure (HP:0002878)2.48794395
43Focal seizures (HP:0007359)2.48597700
44Macrocytic anemia (HP:0001972)2.47229340
45Abnormal hair whorl (HP:0010721)2.47140377
46Absence seizures (HP:0002121)2.45737079
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45140798
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45140798
49Increased intramyocellular lipid droplets (HP:0012240)2.41964094
503-Methylglutaconic aciduria (HP:0003535)2.40707670
51Abnormality of the ileum (HP:0001549)2.40211264
52Generalized tonic-clonic seizures (HP:0002069)2.39373507
53Increased hepatocellular lipid droplets (HP:0006565)2.37733366
54Lethargy (HP:0001254)2.35550371
55Birth length less than 3rd percentile (HP:0003561)2.34924902
56Hyperventilation (HP:0002883)2.34588284
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32590225
58Abnormality of fatty-acid metabolism (HP:0004359)2.32021878
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30932114
60Abnormality of alanine metabolism (HP:0010916)2.30932114
61Hyperalaninemia (HP:0003348)2.30932114
62Poor suck (HP:0002033)2.30858121
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.23833000
64Aplastic anemia (HP:0001915)2.22240682
65Prolonged partial thromboplastin time (HP:0003645)2.22136418
66Abnormality of the preputium (HP:0100587)2.21730314
67Emotional lability (HP:0000712)2.21581186
68Dialeptic seizures (HP:0011146)2.20450043
69Progressive muscle weakness (HP:0003323)2.18118765
70Progressive cerebellar ataxia (HP:0002073)2.17773384
71Renal Fanconi syndrome (HP:0001994)2.16980750
72Hyperlipoproteinemia (HP:0010980)2.14793793
73Generalized aminoaciduria (HP:0002909)2.14013593
74Ketosis (HP:0001946)2.11676381
75Cholecystitis (HP:0001082)2.11499817
76Abnormal gallbladder physiology (HP:0012438)2.11499817
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11077955
78Calf muscle hypertrophy (HP:0008981)2.11007658
79Cerebral hypomyelination (HP:0006808)2.10808195
80Ragged-red muscle fibers (HP:0003200)2.09539647
81Microretrognathia (HP:0000308)2.07070908
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04699858
83Dicarboxylic aciduria (HP:0003215)2.04699858
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04004257
85Oral leukoplakia (HP:0002745)2.02569343
86Methylmalonic acidemia (HP:0002912)2.02438406
87Rough bone trabeculation (HP:0100670)2.01400159
88Anxiety (HP:0000739)2.01382554
89Carpal bone hypoplasia (HP:0001498)2.01276344
90Metabolic acidosis (HP:0001942)2.01193124
91Delayed CNS myelination (HP:0002188)2.00468480
92Ketoacidosis (HP:0001993)2.00242823
93Muscle hypertrophy of the lower extremities (HP:0008968)2.00195927
94Exercise-induced myalgia (HP:0003738)1.99861080
95Abnormality of serum amino acid levels (HP:0003112)1.99301805
96Leukodystrophy (HP:0002415)1.99108930
97Pancytopenia (HP:0001876)1.99040061
98Horseshoe kidney (HP:0000085)1.98598263
99Vomiting (HP:0002013)1.97960413
100Abnormal pupillary function (HP:0007686)1.97287657
101Cholelithiasis (HP:0001081)1.97089357
102Pendular nystagmus (HP:0012043)1.96818819
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.95182364
104Polyphagia (HP:0002591)1.94762714
105Hyperammonemia (HP:0001987)1.94742003
106Progressive external ophthalmoplegia (HP:0000590)1.94378569
107Degeneration of anterior horn cells (HP:0002398)1.94320375
108Abnormality of the anterior horn cell (HP:0006802)1.94320375
109Myotonia (HP:0002486)1.93913179
110Abnormality of placental membranes (HP:0011409)1.93728303
111Amniotic constriction ring (HP:0009775)1.93728303
112Limb dystonia (HP:0002451)1.93701761
113Abnormal gallbladder morphology (HP:0012437)1.91230053
114CNS demyelination (HP:0007305)1.91174203
115Cerebral hemorrhage (HP:0001342)1.90926657
116Nausea (HP:0002018)1.90562783
117Broad distal phalanx of finger (HP:0009836)1.89832648
118Hypokinesia (HP:0002375)1.87889212
119Multiple enchondromatosis (HP:0005701)1.87798428
120Abnormality of methionine metabolism (HP:0010901)1.86808324
121Hypobetalipoproteinemia (HP:0003563)1.86655259
122Exertional dyspnea (HP:0002875)1.86026128
123Visual hallucinations (HP:0002367)1.85444538
124Sparse eyelashes (HP:0000653)1.85169430
125Muscle stiffness (HP:0003552)1.84889529
126Absent thumb (HP:0009777)1.84815033
127Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83967602
128Opisthotonus (HP:0002179)1.83350240
129Hyperglycinemia (HP:0002154)1.82872590
130Hypoglycemic coma (HP:0001325)1.81426964
131Cleft eyelid (HP:0000625)1.81203133
132Abnormal lung lobation (HP:0002101)1.80259231
133Brushfield spots (HP:0001088)1.79394692
134Myoglobinuria (HP:0002913)1.79179789
135Abnormality of glycine metabolism (HP:0010895)1.78983230
136Abnormality of serine family amino acid metabolism (HP:0010894)1.78983230
137Xanthomatosis (HP:0000991)1.78639849
138Methylmalonic aciduria (HP:0012120)1.78363137
139Fetal akinesia sequence (HP:0001989)1.78251664
140Retinal dysplasia (HP:0007973)1.78193867
141Failure to thrive in infancy (HP:0001531)1.74737491
142Cerebral palsy (HP:0100021)1.74474399
143Increased serum pyruvate (HP:0003542)1.74457003
144Abnormality of glycolysis (HP:0004366)1.74457003
145Medial flaring of the eyebrow (HP:0010747)1.73624624
146Renal cortical cysts (HP:0000803)1.73506896
147Syncope (HP:0001279)1.73357492
148Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72740244
149Rhabdomyolysis (HP:0003201)1.72682648
150Exercise-induced muscle cramps (HP:0003710)1.72505214
151Status epilepticus (HP:0002133)1.72221523
152Prolonged QT interval (HP:0001657)1.71717791
153Pallor (HP:0000980)1.70921007
154Abnormal EKG (HP:0003115)1.69825308
155Sudden death (HP:0001699)1.69416496
156X-linked dominant inheritance (HP:0001423)1.67894480
157Gliosis (HP:0002171)1.67819658
158Abnormality of urine glucose concentration (HP:0011016)1.66736938
159Glycosuria (HP:0003076)1.66736938
160Vaginal fistula (HP:0004320)1.66607664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.91935287
2VRK25.58135082
3NME24.04290692
4MAP3K124.02321484
5NTRK33.67662869
6CASK3.44273824
7MAP2K72.98261742
8NEK12.96003263
9SRPK12.40452954
10SIK32.32152800
11PBK2.28619381
12BCKDK2.24820977
13TTK2.24522477
14MAP3K42.22733525
15TESK22.20659967
16VRK12.18727390
17PRPF4B2.06568804
18CDC72.04195550
19MINK12.02539253
20MAP2K41.94863521
21BMPR21.88085692
22RIPK41.84929796
23GRK71.83919301
24EPHA41.82746007
25MYLK1.74651310
26NME11.73005442
27GRK51.72775666
28PINK11.72306873
29WEE11.72247688
30BRSK11.71460963
31PLK11.67796071
32DAPK21.66968016
33MST41.65881143
34ARAF1.64970040
35MUSK1.60862630
36MAP3K141.58801715
37TAF11.54081464
38PLK31.48610104
39AURKA1.47706250
40AKT31.45150576
41SGK21.41669478
42LMTK21.40638904
43MAP3K131.37548120
44IRAK31.34955866
45TESK11.32088814
46ADRBK21.29213737
47PHKG21.23739098
48PHKG11.23739098
49MAP4K21.23270758
50IRAK41.22125873
51AURKB1.21536077
52MAPK131.20738142
53NEK21.19967365
54CCNB11.19668190
55CAMKK21.19002620
56CHEK21.18909642
57INSRR1.17999405
58TXK1.17532214
59EIF2AK11.17446073
60STK161.16027589
61TNK21.13591900
62PLK41.12296987
63OBSCN1.08682228
64BMPR1B1.08305263
65SGK4941.07888856
66SGK2231.07888856
67SMG11.07105708
68PRKCG1.06543586
69MAP2K61.06450835
70TRIM281.06300097
71TNIK1.05943074
72CAMK2A1.05081937
73BRSK21.05078103
74MAPK121.01987768
75STK41.01930625
76PLK20.99556421
77KDR0.98939865
78DYRK20.97920633
79ATR0.97773769
80TLK10.96268630
81DAPK10.96196525
82CSNK1G30.94579158
83PRKCE0.92796504
84ZAK0.92593456
85CAMK2G0.90962422
86CAMK2D0.89667755
87EIF2AK30.89650703
88PDK20.87445760
89MAP3K90.87305894
90LIMK10.86685057
91MAP3K110.85205733
92CDK70.84690564
93MAPKAPK50.80863931
94STK240.80044647
95BRAF0.78927553
96PDK40.78557846
97PDK30.78557846
98CSNK1G10.78069639
99DYRK30.76132008
100ADRBK10.71640800
101NTRK10.70754570
102PRKCI0.70306756
103RPS6KA50.70004691
104CSNK1A1L0.69838898
105MARK10.68788294
106BCR0.67983947
107STK38L0.67518597
108ABL20.67438424
109TIE10.66671812
110CSNK1G20.66366303
111UHMK10.65073625
112TAOK20.63979237
113PAK10.61961483
114TBK10.61379551
115PAK40.60913043
116CSNK2A10.60681505
117CAMK2B0.60366135
118ERBB30.60128304
119PRKACA0.60110572
120NTRK20.58849558
121PTK2B0.58833827
122PIK3CG0.57964713
123SGK30.57948643
124CDK50.57595585
125MAP2K10.57587449
126CHEK10.55712138
127EIF2AK20.54856006
128LRRK20.54529886
129SYK0.54358438
130CSNK2A20.54279579
131ILK0.53811747
132MAP3K80.52483059
133MAP2K20.52097249
134CDK11A0.49467989
135RPS6KA40.48605158
136CDK40.48171136
137YES10.47868758
138MAPK70.47850948
139CAMK10.46766406
140FRK0.44670936
141CDK140.44370884
142STK380.43940283
143MAPKAPK30.42908321
144GRK60.42718169
145CDK150.42065476
146CDK180.41563788
147NUAK10.40554378
148MAP3K60.39436067
149PRKCA0.38836770
150PRKACG0.38579381
151RPS6KB10.37968385
152MAP3K50.37848634
153PRKCD0.37587416
154CDK80.37193169
155IRAK10.37043988
156TEC0.36578793
157CDK10.35070974
158IKBKE0.35019027
159CDK190.34812811
160SGK10.34628220
161FGFR40.34441968
162TSSK60.34087667
163DAPK30.33950772
164MAPK110.33894966
165RPS6KB20.33242687
166DYRK1B0.33189662
167PIK3CA0.32766552
168AKT20.32714795
169PIM20.31881209
170PRKCZ0.31609335
171GRK10.30620903
172ATM0.29146349
173IRAK20.28744923
174WNK30.27503455

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.03763564
2Ribosome_Homo sapiens_hsa030103.73078571
3Parkinsons disease_Homo sapiens_hsa050123.45845597
4DNA replication_Homo sapiens_hsa030302.94250287
5Alzheimers disease_Homo sapiens_hsa050102.60494955
6Synaptic vesicle cycle_Homo sapiens_hsa047212.55065973
7Base excision repair_Homo sapiens_hsa034102.54794338
8RNA polymerase_Homo sapiens_hsa030202.50325302
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47249242
10Nicotine addiction_Homo sapiens_hsa050332.32198258
11Mismatch repair_Homo sapiens_hsa034302.28242129
12Protein export_Homo sapiens_hsa030602.26242776
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25541656
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.25503004
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16945396
16Collecting duct acid secretion_Homo sapiens_hsa049662.15733919
17Huntingtons disease_Homo sapiens_hsa050162.15148006
18Primary bile acid biosynthesis_Homo sapiens_hsa001202.12483979
19Propanoate metabolism_Homo sapiens_hsa006402.07828149
20Pyrimidine metabolism_Homo sapiens_hsa002402.03939820
21Homologous recombination_Homo sapiens_hsa034401.99892816
22Spliceosome_Homo sapiens_hsa030401.96782975
23Cardiac muscle contraction_Homo sapiens_hsa042601.94960157
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79200169
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71576349
26Pyruvate metabolism_Homo sapiens_hsa006201.68631228
27Nucleotide excision repair_Homo sapiens_hsa034201.64096752
28Peroxisome_Homo sapiens_hsa041461.63640616
29Fatty acid degradation_Homo sapiens_hsa000711.62728275
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61651387
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61388924
32Biosynthesis of amino acids_Homo sapiens_hsa012301.59020430
33Fatty acid elongation_Homo sapiens_hsa000621.55959827
34Fanconi anemia pathway_Homo sapiens_hsa034601.55930253
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55347434
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53131511
37Taste transduction_Homo sapiens_hsa047421.46411227
38Phenylalanine metabolism_Homo sapiens_hsa003601.46381203
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42550615
40Olfactory transduction_Homo sapiens_hsa047401.41542116
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41178841
42One carbon pool by folate_Homo sapiens_hsa006701.39922859
43Fatty acid metabolism_Homo sapiens_hsa012121.36947864
44RNA transport_Homo sapiens_hsa030131.35867060
45GABAergic synapse_Homo sapiens_hsa047271.34482659
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32719890
47beta-Alanine metabolism_Homo sapiens_hsa004101.31131141
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27795467
49Butanoate metabolism_Homo sapiens_hsa006501.26974365
50Basal transcription factors_Homo sapiens_hsa030221.23338021
51Tyrosine metabolism_Homo sapiens_hsa003501.21829662
52Purine metabolism_Homo sapiens_hsa002301.21019154
53Proteasome_Homo sapiens_hsa030501.20550020
54Morphine addiction_Homo sapiens_hsa050321.19479871
55Tryptophan metabolism_Homo sapiens_hsa003801.18995153
56Cell cycle_Homo sapiens_hsa041101.18743022
57RNA degradation_Homo sapiens_hsa030181.16830502
58Non-homologous end-joining_Homo sapiens_hsa034501.15411071
59Arginine biosynthesis_Homo sapiens_hsa002201.14434251
60Regulation of autophagy_Homo sapiens_hsa041401.12020512
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11557598
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07958727
63Circadian entrainment_Homo sapiens_hsa047131.04242867
64PPAR signaling pathway_Homo sapiens_hsa033201.02877316
65Histidine metabolism_Homo sapiens_hsa003401.01531201
66N-Glycan biosynthesis_Homo sapiens_hsa005101.01488260
67Insulin secretion_Homo sapiens_hsa049110.99225133
68Glutathione metabolism_Homo sapiens_hsa004800.98994441
69Carbon metabolism_Homo sapiens_hsa012000.98713527
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97940780
71Vibrio cholerae infection_Homo sapiens_hsa051100.97821480
72Sulfur metabolism_Homo sapiens_hsa009200.93495752
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93207798
74Serotonergic synapse_Homo sapiens_hsa047260.93195114
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91747707
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87331160
77Amphetamine addiction_Homo sapiens_hsa050310.84232023
78Calcium signaling pathway_Homo sapiens_hsa040200.83579612
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82895189
80Dopaminergic synapse_Homo sapiens_hsa047280.79268533
81Glutamatergic synapse_Homo sapiens_hsa047240.79252814
82Rheumatoid arthritis_Homo sapiens_hsa053230.76775941
83Caffeine metabolism_Homo sapiens_hsa002320.75870264
84p53 signaling pathway_Homo sapiens_hsa041150.75592578
85Selenocompound metabolism_Homo sapiens_hsa004500.75444210
86Complement and coagulation cascades_Homo sapiens_hsa046100.75351808
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74875603
88Chemical carcinogenesis_Homo sapiens_hsa052040.74463571
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74417096
90Metabolic pathways_Homo sapiens_hsa011000.73024585
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72749800
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72307679
93Starch and sucrose metabolism_Homo sapiens_hsa005000.71663248
94Steroid biosynthesis_Homo sapiens_hsa001000.71474222
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70903492
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70205572
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.69256319
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68612877
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67667461
100Pentose phosphate pathway_Homo sapiens_hsa000300.66470236
101Cholinergic synapse_Homo sapiens_hsa047250.66422537
102Salivary secretion_Homo sapiens_hsa049700.66252040
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65662474
104Long-term potentiation_Homo sapiens_hsa047200.61449589
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61005507
106Oocyte meiosis_Homo sapiens_hsa041140.60323987
107Renin secretion_Homo sapiens_hsa049240.60312275
108ABC transporters_Homo sapiens_hsa020100.60232342
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.58129497
110Fructose and mannose metabolism_Homo sapiens_hsa000510.54896901
111Bile secretion_Homo sapiens_hsa049760.54529944
112Folate biosynthesis_Homo sapiens_hsa007900.52838217
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52490459
114Vitamin B6 metabolism_Homo sapiens_hsa007500.52155054
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51568947
116mRNA surveillance pathway_Homo sapiens_hsa030150.51470140
117Glycerolipid metabolism_Homo sapiens_hsa005610.51348757
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50947315
119Retinol metabolism_Homo sapiens_hsa008300.50177164
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49087406
121Phagosome_Homo sapiens_hsa041450.48250081
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46174391
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.45800112
124Cocaine addiction_Homo sapiens_hsa050300.42803357
125Arginine and proline metabolism_Homo sapiens_hsa003300.42014553
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41215610
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.40807615
128Epstein-Barr virus infection_Homo sapiens_hsa051690.40521779
129Vitamin digestion and absorption_Homo sapiens_hsa049770.40371456
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40344146
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40126758
132Type I diabetes mellitus_Homo sapiens_hsa049400.39858772
133Systemic lupus erythematosus_Homo sapiens_hsa053220.39835935
134Sulfur relay system_Homo sapiens_hsa041220.39447066
135Staphylococcus aureus infection_Homo sapiens_hsa051500.39215807
136Galactose metabolism_Homo sapiens_hsa000520.39009290
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38274589
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.37885431
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36256805
140Phototransduction_Homo sapiens_hsa047440.32340593
141Primary immunodeficiency_Homo sapiens_hsa053400.27302009
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27243863
143Fat digestion and absorption_Homo sapiens_hsa049750.26698034
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23912520
145Alcoholism_Homo sapiens_hsa050340.23151705
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.11854945

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