EMC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.26685059
2ATP synthesis coupled proton transport (GO:0015986)5.85787564
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.85787564
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.48930529
5chaperone-mediated protein transport (GO:0072321)5.33199734
6respiratory electron transport chain (GO:0022904)5.01571007
7proteasome assembly (GO:0043248)4.98279282
8electron transport chain (GO:0022900)4.90394177
9protein complex biogenesis (GO:0070271)4.73126882
10cullin deneddylation (GO:0010388)4.50758814
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.48416950
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.48416950
13NADH dehydrogenase complex assembly (GO:0010257)4.48416950
14regulation of mitochondrial translation (GO:0070129)4.44194644
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.40771950
16mitochondrial respiratory chain complex assembly (GO:0033108)4.40058439
17protein deneddylation (GO:0000338)4.31795737
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.09310590
19water-soluble vitamin biosynthetic process (GO:0042364)4.08066434
20regulation of cellular amino acid metabolic process (GO:0006521)4.03107775
21protein targeting to mitochondrion (GO:0006626)4.02566737
22protein neddylation (GO:0045116)3.95243665
23establishment of protein localization to mitochondrion (GO:0072655)3.95142314
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90023812
25energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.84453778
26ATP hydrolysis coupled proton transport (GO:0015991)3.84453778
27guanosine-containing compound biosynthetic process (GO:1901070)3.81497455
28NADH metabolic process (GO:0006734)3.79106292
29protein localization to mitochondrion (GO:0070585)3.74324959
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.74209458
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.74209458
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.72046233
33termination of RNA polymerase III transcription (GO:0006386)3.72046233
34L-methionine salvage (GO:0071267)3.71928927
35L-methionine biosynthetic process (GO:0071265)3.71928927
36amino acid salvage (GO:0043102)3.71928927
37respiratory chain complex IV assembly (GO:0008535)3.69546189
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67987464
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.65644950
40pseudouridine synthesis (GO:0001522)3.65607934
41DNA deamination (GO:0045006)3.63608439
42synaptic vesicle exocytosis (GO:0016079)3.60387465
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59002212
44oxidative phosphorylation (GO:0006119)3.57030772
45hydrogen ion transmembrane transport (GO:1902600)3.54022414
46negative regulation of ligase activity (GO:0051352)3.52295295
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52295295
48cytochrome complex assembly (GO:0017004)3.51257760
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49530694
50platelet dense granule organization (GO:0060155)3.48752250
51transferrin transport (GO:0033572)3.43106648
527-methylguanosine mRNA capping (GO:0006370)3.41995721
53protein-cofactor linkage (GO:0018065)3.40678617
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36792312
55deoxyribose phosphate biosynthetic process (GO:0046385)3.35527140
562-deoxyribonucleotide biosynthetic process (GO:0009265)3.35527140
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35270207
58GDP-mannose metabolic process (GO:0019673)3.33180380
59neuronal action potential propagation (GO:0019227)3.33048138
60GTP biosynthetic process (GO:0006183)3.32575053
61RNA capping (GO:0036260)3.32455548
627-methylguanosine RNA capping (GO:0009452)3.32455548
63rRNA modification (GO:0000154)3.30665795
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.29835326
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29742448
66positive regulation of mitochondrial fission (GO:0090141)3.29122164
67ATP biosynthetic process (GO:0006754)3.29052547
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28693202
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28693202
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28693202
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27806853
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27806853
73purine nucleoside triphosphate biosynthetic process (GO:0009145)3.27521855
74behavioral response to nicotine (GO:0035095)3.25104446
75regulation of cellular amine metabolic process (GO:0033238)3.18511344
76regulation of cellular respiration (GO:0043457)3.17177467
77positive regulation of ligase activity (GO:0051351)3.16839331
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16199626
79signal transduction involved in DNA damage checkpoint (GO:0072422)3.16199626
80DNA damage response, detection of DNA damage (GO:0042769)3.14446366
81deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.14098543
82trivalent inorganic cation transport (GO:0072512)3.13537223
83ferric iron transport (GO:0015682)3.13537223
84base-excision repair, AP site formation (GO:0006285)3.12643065
85proton transport (GO:0015992)3.11380542
86signal transduction involved in cell cycle checkpoint (GO:0072395)3.11313174
87inner mitochondrial membrane organization (GO:0007007)3.09450264
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08267145
89DNA double-strand break processing (GO:0000729)3.07554322
90mannosylation (GO:0097502)3.06004040
91hydrogen transport (GO:0006818)3.04879898
92metallo-sulfur cluster assembly (GO:0031163)3.04629148
93iron-sulfur cluster assembly (GO:0016226)3.04629148
94GMP metabolic process (GO:0046037)3.03066634
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00709224
96viral mRNA export from host cell nucleus (GO:0046784)2.97123557
97regulation of oxidative phosphorylation (GO:0002082)2.96180222
98intracellular protein transmembrane import (GO:0044743)2.95400317
99mitochondrial transport (GO:0006839)2.94773255
100tRNA processing (GO:0008033)2.91024029
101nucleoside diphosphate phosphorylation (GO:0006165)2.89806040
102ribonucleoside triphosphate biosynthetic process (GO:0009201)2.88313685
103aldehyde catabolic process (GO:0046185)2.87344661
104dopamine transport (GO:0015872)2.87078226
105negative regulation of dendrite morphogenesis (GO:0050774)2.84389500
106ubiquinone biosynthetic process (GO:0006744)2.84297078
107nucleoside triphosphate biosynthetic process (GO:0009142)2.83468855
108purine nucleobase biosynthetic process (GO:0009113)2.82571702
109antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80829287
110UTP biosynthetic process (GO:0006228)2.80659701
111DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.80145250
112regulation of ubiquitin-protein transferase activity (GO:0051438)2.79626691
113glutamate secretion (GO:0014047)2.77089569
114peptidyl-histidine modification (GO:0018202)2.75945482
115formation of translation preinitiation complex (GO:0001731)2.75194631
116preassembly of GPI anchor in ER membrane (GO:0016254)2.74236268
117branched-chain amino acid catabolic process (GO:0009083)2.73055055
118cellular component biogenesis (GO:0044085)2.71418756
119regulation of ligase activity (GO:0051340)2.71035165
120protein localization to synapse (GO:0035418)2.70518015
121regulation of cilium movement (GO:0003352)2.65764554
122regulation of mitotic spindle checkpoint (GO:1903504)2.65462001
123regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65462001
124anterograde synaptic vesicle transport (GO:0048490)2.65137831
125DNA catabolic process, exonucleolytic (GO:0000738)2.64839605
126maturation of 5.8S rRNA (GO:0000460)2.64291712
127ubiquinone metabolic process (GO:0006743)2.62063817
128positive regulation of cell cycle arrest (GO:0071158)2.61472091
129spliceosomal snRNP assembly (GO:0000387)2.61448691
130deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60136332
131deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.59310279
132GPI anchor metabolic process (GO:0006505)2.59018353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.86609953
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.46715098
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.34055036
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.27124004
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.02694547
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.85634077
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.75516648
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.37282306
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.21050601
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99195617
11ZNF274_21170338_ChIP-Seq_K562_Hela2.97331166
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86416926
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.82469126
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.78976990
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63008242
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.58030969
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.53820256
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48907104
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.41858355
20VDR_23849224_ChIP-Seq_CD4+_Human2.36261630
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.33086344
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32104467
23DCP1A_22483619_ChIP-Seq_HELA_Human2.28276372
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05955096
25GABP_19822575_ChIP-Seq_HepG2_Human2.03941569
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98708091
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98652464
28EZH2_22144423_ChIP-Seq_EOC_Human1.95209857
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95094926
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82657032
31IGF1R_20145208_ChIP-Seq_DFB_Human1.78920294
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72534683
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69090329
34EWS_26573619_Chip-Seq_HEK293_Human1.68677892
35GBX2_23144817_ChIP-Seq_PC3_Human1.64454157
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64375111
37SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.63818835
38FOXP3_21729870_ChIP-Seq_TREG_Human1.63663516
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61747859
40XRN2_22483619_ChIP-Seq_HELA_Human1.61067345
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.60426604
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55654760
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54031708
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51739631
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49625657
46TAF15_26573619_Chip-Seq_HEK293_Human1.49420637
47TTF2_22483619_ChIP-Seq_HELA_Human1.48322546
48ELK1_19687146_ChIP-ChIP_HELA_Human1.47027380
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46084447
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42630124
51REST_21632747_ChIP-Seq_MESCs_Mouse1.42386484
52CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.42107682
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39744537
54VDR_22108803_ChIP-Seq_LS180_Human1.38734535
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37286182
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36785526
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36599793
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35865048
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33561783
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.32357381
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28711472
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26934213
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26645249
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.25526858
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22803054
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21600793
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18031952
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12581858
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12356661
70IRF1_19129219_ChIP-ChIP_H3396_Human1.12312510
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11320634
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10028041
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07843094
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07579807
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05614553
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05142230
77AR_20517297_ChIP-Seq_VCAP_Human1.03432572
78NANOG_19829295_ChIP-Seq_ESCs_Human1.03282048
79SOX2_19829295_ChIP-Seq_ESCs_Human1.03282048
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03186693
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02668615
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.02544709
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02544709
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00637530
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99972316
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99684617
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97423416
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97271703
89ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97258067
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93523400
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92260390
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92181035
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91058631
94MYC_18940864_ChIP-ChIP_HL60_Human0.89553905
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89200421
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88007373
97KDM5A_27292631_Chip-Seq_BREAST_Human0.85882569
98ER_23166858_ChIP-Seq_MCF-7_Human0.84504605
99REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82947838
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82875676
101GATA3_21878914_ChIP-Seq_MCF-7_Human0.82584669
102SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82386863
103JUN_21703547_ChIP-Seq_K562_Human0.81806699
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.81523022
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.81370923
106TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81332997
107KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81020168
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.79308414
109NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79004722
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.78612009
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78606554
112FUS_26573619_Chip-Seq_HEK293_Human0.77406390
113HTT_18923047_ChIP-ChIP_STHdh_Human0.76658459
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76390454
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75783447
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.75472623
117ZNF263_19887448_ChIP-Seq_K562_Human0.74901068
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74684861
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73486831
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73403779
121P300_19829295_ChIP-Seq_ESCs_Human0.72201864
122EOMES_21245162_ChIP-Seq_HESCs_Human0.71990881
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.71793756
124FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71253833
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70438092
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67804633
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.67733852
128JARID2_20064375_ChIP-Seq_MESCs_Mouse0.67363489
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67212419
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.66879669
131TP53_22573176_ChIP-Seq_HFKS_Human0.66422237
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.66153019
133NCOR_22424771_ChIP-Seq_293T_Human0.66018263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.44362425
2MP0004859_abnormal_synaptic_plasticity3.46481476
3MP0001968_abnormal_touch/_nociception3.11458102
4MP0002736_abnormal_nociception_after3.07189691
5MP0001984_abnormal_olfaction2.91410694
6MP0001529_abnormal_vocalization2.89607585
7MP0009046_muscle_twitch2.85804428
8MP0003635_abnormal_synaptic_transmissio2.80883050
9MP0004270_analgesia2.74057385
10MP0008058_abnormal_DNA_repair2.63383514
11MP0009745_abnormal_behavioral_response2.62259670
12MP0002102_abnormal_ear_morphology2.60420452
13MP0002064_seizures2.57173384
14MP0002735_abnormal_chemical_nociception2.54420397
15MP0002272_abnormal_nervous_system2.47347623
16MP0002734_abnormal_mechanical_nocicepti2.46731373
17MP0006072_abnormal_retinal_apoptosis2.40526351
18MP0006276_abnormal_autonomic_nervous2.32318256
19MP0006036_abnormal_mitochondrial_physio2.28473270
20MP0003011_delayed_dark_adaptation2.27238761
21MP0002063_abnormal_learning/memory/cond2.26207186
22MP0001905_abnormal_dopamine_level2.22705737
23MP0003879_abnormal_hair_cell2.21348284
24MP0006292_abnormal_olfactory_placode2.12440083
25MP0002572_abnormal_emotion/affect_behav2.12302647
26MP0002876_abnormal_thyroid_physiology2.09052942
27MP0002822_catalepsy2.08070194
28MP0008875_abnormal_xenobiotic_pharmacok2.07235483
29MP0004142_abnormal_muscle_tone2.04997395
30MP0002733_abnormal_thermal_nociception1.95872780
31MP0001440_abnormal_grooming_behavior1.95782057
32MP0006035_abnormal_mitochondrial_morpho1.94344553
33MP0003806_abnormal_nucleotide_metabolis1.92451347
34MP0003693_abnormal_embryo_hatching1.90432220
35MP0008260_abnormal_autophagy1.88734721
36MP0001501_abnormal_sleep_pattern1.88107017
37MP0001970_abnormal_pain_threshold1.86547256
38MP0002067_abnormal_sensory_capabilities1.85075461
39MP0003195_calcinosis1.83298295
40MP0003329_amyloid_beta_deposits1.76234876
41MP0005253_abnormal_eye_physiology1.75035494
42MP0001542_abnormal_bone_strength1.72385294
43MP0003787_abnormal_imprinting1.67578883
44MP0003718_maternal_effect1.65129797
45MP0001986_abnormal_taste_sensitivity1.65101672
46MP0002184_abnormal_innervation1.59945598
47MP0001486_abnormal_startle_reflex1.59051378
48MP0001188_hyperpigmentation1.58412434
49MP0004924_abnormal_behavior1.46712876
50MP0005386_behavior/neurological_phenoty1.46712876
51MP0002938_white_spotting1.44620162
52MP0003646_muscle_fatigue1.43280297
53MP0002234_abnormal_pharynx_morphology1.35508728
54MP0003136_yellow_coat_color1.32383991
55MP0003121_genomic_imprinting1.32152848
56MP0003186_abnormal_redox_activity1.30239426
57MP0008995_early_reproductive_senescence1.29030096
58MP0005646_abnormal_pituitary_gland1.26788242
59MP0005423_abnormal_somatic_nervous1.25410550
60MP0004133_heterotaxia1.24859183
61MP0008877_abnormal_DNA_methylation1.23793032
62MP0008872_abnormal_physiological_respon1.20631657
63MP0002837_dystrophic_cardiac_calcinosis1.20463128
64MP0004215_abnormal_myocardial_fiber1.18439722
65MP0004957_abnormal_blastocyst_morpholog1.18221217
66MP0001764_abnormal_homeostasis1.16082655
67MP0002557_abnormal_social/conspecific_i1.14231500
68MP0000631_abnormal_neuroendocrine_gland1.13134812
69MP0002066_abnormal_motor_capabilities/c1.12340630
70MP0009379_abnormal_foot_pigmentation1.12196572
71MP0002090_abnormal_vision1.10463508
72MP0004145_abnormal_muscle_electrophysio1.09731797
73MP0005084_abnormal_gallbladder_morpholo1.09222106
74MP0005551_abnormal_eye_electrophysiolog1.08394932
75MP0002160_abnormal_reproductive_system1.06973911
76MP0010094_abnormal_chromosome_stability1.03299552
77MP0005379_endocrine/exocrine_gland_phen1.03288011
78MP0005075_abnormal_melanosome_morpholog1.01437029
79MP0004811_abnormal_neuron_physiology1.00852724
80MP0002229_neurodegeneration1.00583782
81MP0001485_abnormal_pinna_reflex1.00509192
82MP0005499_abnormal_olfactory_system1.00493007
83MP0005394_taste/olfaction_phenotype1.00493007
84MP0004885_abnormal_endolymph0.98527334
85MP0003878_abnormal_ear_physiology0.97652631
86MP0005377_hearing/vestibular/ear_phenot0.97652631
87MP0002095_abnormal_skin_pigmentation0.96692254
88MP0009697_abnormal_copulation0.96546429
89MP0001963_abnormal_hearing_physiology0.95278487
90MP0002882_abnormal_neuron_morphology0.95226531
91MP0002653_abnormal_ependyma_morphology0.95137356
92MP0000372_irregular_coat_pigmentation0.94628808
93MP0008569_lethality_at_weaning0.93687472
94MP0003123_paternal_imprinting0.92898864
95MP0002163_abnormal_gland_morphology0.90728379
96MP0000647_abnormal_sebaceous_gland0.89940140
97MP0008789_abnormal_olfactory_epithelium0.89372787
98MP0002210_abnormal_sex_determination0.89308488
99MP0003786_premature_aging0.88056223
100MP0005410_abnormal_fertilization0.87501151
101MP0001929_abnormal_gametogenesis0.87334469
102MP0002277_abnormal_respiratory_mucosa0.86437394
103MP0008932_abnormal_embryonic_tissue0.85806852
104MP0003567_abnormal_fetal_cardiomyocyte0.85803702
105MP0002638_abnormal_pupillary_reflex0.84442567
106MP0000749_muscle_degeneration0.84158802
107MP0002332_abnormal_exercise_endurance0.82539356
108MP0004036_abnormal_muscle_relaxation0.81604105
109MP0004484_altered_response_of0.80716815
110MP0005195_abnormal_posterior_eye0.79710111
111MP0005645_abnormal_hypothalamus_physiol0.79706120
112MP0001919_abnormal_reproductive_system0.79139623
113MP0008007_abnormal_cellular_replicative0.79130868
114MP0002752_abnormal_somatic_nervous0.78798336
115MP0000653_abnormal_sex_gland0.78640315
116MP0005389_reproductive_system_phenotype0.78609923
117MP0008775_abnormal_heart_ventricle0.78360796
118MP0000358_abnormal_cell_content/0.77651729
119MP0000955_abnormal_spinal_cord0.77324164
120MP0005636_abnormal_mineral_homeostasis0.76973980
121MP0005171_absent_coat_pigmentation0.76544727
122MP0000049_abnormal_middle_ear0.76309444
123MP0000751_myopathy0.75452167
124MP0005332_abnormal_amino_acid0.74050944
125MP0004043_abnormal_pH_regulation0.73616729
126MP0003122_maternal_imprinting0.73522612
127MP0002909_abnormal_adrenal_gland0.72659044
128MP0003137_abnormal_impulse_conducting0.72260325
129MP0004147_increased_porphyrin_level0.70956038
130MP0001664_abnormal_digestion0.68923377
131MP0000604_amyloidosis0.68751492
132MP0010386_abnormal_urinary_bladder0.68218016
133MP0005535_abnormal_body_temperature0.66283790
134MP0002751_abnormal_autonomic_nervous0.65131013
135MP0000681_abnormal_thyroid_gland0.64096741
136MP0005330_cardiomyopathy0.63988986

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.97714543
2Abnormal mitochondria in muscle tissue (HP:0008316)5.56739352
3Mitochondrial inheritance (HP:0001427)5.32596262
4Acute encephalopathy (HP:0006846)4.88978761
5Progressive macrocephaly (HP:0004481)4.88495870
6Increased CSF lactate (HP:0002490)4.87410499
7Hepatocellular necrosis (HP:0001404)4.84278153
8Focal motor seizures (HP:0011153)4.60240982
9Hepatic necrosis (HP:0002605)4.14194362
10Myokymia (HP:0002411)3.79157370
11Increased hepatocellular lipid droplets (HP:0006565)3.67321734
12Abnormality of glycolysis (HP:0004366)3.58605831
13Increased serum pyruvate (HP:0003542)3.58605831
14Atonic seizures (HP:0010819)3.55768540
15Lactic acidosis (HP:0003128)3.55031673
16Increased serum lactate (HP:0002151)3.53988888
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.50344350
18Abnormality of alanine metabolism (HP:0010916)3.50344350
19Hyperalaninemia (HP:0003348)3.50344350
20Cerebral hypomyelination (HP:0006808)3.49921631
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.48610932
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.48610932
233-Methylglutaconic aciduria (HP:0003535)3.45759036
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.40580143
25Delusions (HP:0000746)3.38291706
26Respiratory failure (HP:0002878)3.32029540
27Cerebral edema (HP:0002181)3.31552288
28Neuroendocrine neoplasm (HP:0100634)3.17856850
29Exercise intolerance (HP:0003546)3.16375993
30Lipid accumulation in hepatocytes (HP:0006561)3.16054377
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.15699162
32Optic disc pallor (HP:0000543)3.08098365
33Poor suck (HP:0002033)3.08037307
34Molar tooth sign on MRI (HP:0002419)3.00185349
35Abnormality of midbrain morphology (HP:0002418)3.00185349
36Pheochromocytoma (HP:0002666)2.99412455
37Epileptic encephalopathy (HP:0200134)2.98955575
38CNS demyelination (HP:0007305)2.96444444
39Renal Fanconi syndrome (HP:0001994)2.92893404
40Increased intramyocellular lipid droplets (HP:0012240)2.90339857
41Emotional lability (HP:0000712)2.90312373
42Absence seizures (HP:0002121)2.87650279
43Unsteady gait (HP:0002317)2.83733020
44Methylmalonic acidemia (HP:0002912)2.75236492
45True hermaphroditism (HP:0010459)2.69447330
46Febrile seizures (HP:0002373)2.67900651
47Dialeptic seizures (HP:0011146)2.62779696
48Leukodystrophy (HP:0002415)2.61834536
49Hyperventilation (HP:0002883)2.58231452
50Focal seizures (HP:0007359)2.43532894
51Nephronophthisis (HP:0000090)2.38107554
52Abolished electroretinogram (ERG) (HP:0000550)2.37066516
53Congenital stationary night blindness (HP:0007642)2.35884895
54Abnormal protein glycosylation (HP:0012346)2.35873116
55Abnormal glycosylation (HP:0012345)2.35873116
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35873116
57Abnormal protein N-linked glycosylation (HP:0012347)2.35873116
58Visual hallucinations (HP:0002367)2.33468859
59Respiratory difficulties (HP:0002880)2.32435379
60Medial flaring of the eyebrow (HP:0010747)2.32024227
61Increased muscle lipid content (HP:0009058)2.31181085
62Lethargy (HP:0001254)2.24119082
63Exertional dyspnea (HP:0002875)2.20216550
64Type II lissencephaly (HP:0007260)2.12010873
65CNS hypomyelination (HP:0003429)2.11935753
66Microvesicular hepatic steatosis (HP:0001414)2.11336269
67Renal cortical cysts (HP:0000803)2.10350811
68Generalized tonic-clonic seizures (HP:0002069)2.10110140
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09219887
70Pancreatic fibrosis (HP:0100732)2.08489518
71X-linked dominant inheritance (HP:0001423)2.08439074
72Pendular nystagmus (HP:0012043)2.07469592
73Gait imbalance (HP:0002141)2.07266726
74Abnormal hair whorl (HP:0010721)2.07238302
75Degeneration of anterior horn cells (HP:0002398)2.05392938
76Abnormality of the anterior horn cell (HP:0006802)2.05392938
77Congenital primary aphakia (HP:0007707)2.03915850
78Nephrogenic diabetes insipidus (HP:0009806)2.02912696
79Abnormality of serum amino acid levels (HP:0003112)2.01955856
80Sclerocornea (HP:0000647)2.01461402
81Generalized aminoaciduria (HP:0002909)2.00309355
82Abnormality of the labia minora (HP:0012880)1.99312594
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98924926
84Dysautonomia (HP:0002459)1.97043431
85Progressive external ophthalmoplegia (HP:0000590)1.96417773
86Abnormality of the renal cortex (HP:0011035)1.95621329
87Abnormality of renal resorption (HP:0011038)1.94300590
88Postnatal microcephaly (HP:0005484)1.91418109
89Abnormality of the renal medulla (HP:0100957)1.89622630
90Congenital, generalized hypertrichosis (HP:0004540)1.87168913
91Rough bone trabeculation (HP:0100670)1.86745475
92Progressive microcephaly (HP:0000253)1.86125671
93Ventricular fibrillation (HP:0001663)1.85821688
94Retinal dysplasia (HP:0007973)1.85503458
95Microretrognathia (HP:0000308)1.84619061
96Limb dystonia (HP:0002451)1.84497015
97Polyphagia (HP:0002591)1.81753168
98Colon cancer (HP:0003003)1.81250211
99Dicarboxylic aciduria (HP:0003215)1.80002817
100Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80002817
101Death in infancy (HP:0001522)1.78369168
102Abnormal number of erythroid precursors (HP:0012131)1.78093597
103Fetal akinesia sequence (HP:0001989)1.77981929
104Abnormal rod and cone electroretinograms (HP:0008323)1.77663238
105Gliosis (HP:0002171)1.75938307
106Inability to walk (HP:0002540)1.75842006
107Aplastic anemia (HP:0001915)1.74571295
108Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74301431
109Anxiety (HP:0000739)1.73867426
110Methylmalonic aciduria (HP:0012120)1.72754504
111Abnormality of cells of the erythroid lineage (HP:0012130)1.70956603
112Abnormal pupillary function (HP:0007686)1.69963126
113Pancytopenia (HP:0001876)1.69355401
114Birth length less than 3rd percentile (HP:0003561)1.69052995
115Abnormality of serine family amino acid metabolism (HP:0010894)1.68949808
116Abnormality of glycine metabolism (HP:0010895)1.68949808
117Short tibia (HP:0005736)1.68700135
118Vaginal atresia (HP:0000148)1.68190009
119Oligomenorrhea (HP:0000876)1.67025967
120Genital tract atresia (HP:0001827)1.66282158
121Hyperglycinuria (HP:0003108)1.65319361
122Breast hypoplasia (HP:0003187)1.64984495
123Pancreatic cysts (HP:0001737)1.64499890
124Hypothermia (HP:0002045)1.64345287
125Hypoplasia of the uterus (HP:0000013)1.63155442
126Progressive inability to walk (HP:0002505)1.63026150
127Hyperglycinemia (HP:0002154)1.62927510
128Attenuation of retinal blood vessels (HP:0007843)1.62626496
129Gout (HP:0001997)1.62251006
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.62216578
131Aplasia/hypoplasia of the uterus (HP:0008684)1.61782393
132Irregular epiphyses (HP:0010582)1.61167498
133Carpal bone hypoplasia (HP:0001498)1.61006764
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.59850508
135Reduced antithrombin III activity (HP:0001976)1.59802313
136Type I transferrin isoform profile (HP:0003642)1.59777130
137Type 2 muscle fiber atrophy (HP:0003554)1.59291513
138Premature ovarian failure (HP:0008209)1.59288518
139Abnormal autonomic nervous system physiology (HP:0012332)1.58708644
140Glycosuria (HP:0003076)1.58275192
141Abnormality of urine glucose concentration (HP:0011016)1.58275192
142Spastic paraparesis (HP:0002313)1.57917996
143Progressive cerebellar ataxia (HP:0002073)1.56881761
144Patent foramen ovale (HP:0001655)1.56171546
145Blindness (HP:0000618)1.55760282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.60646542
2ARAF3.46918854
3MAP3K123.44468651
4CASK3.01518546
5NME12.87892368
6STK162.80483818
7VRK22.73910029
8BUB12.61588632
9MAP4K22.43267453
10WNK32.34869608
11FRK2.32119092
12TRIM282.28927552
13MAP2K72.15235199
14AKT32.08270001
15PLK22.00294903
16EPHA41.98297168
17CCNB11.95243550
18NUAK11.94365171
19BRAF1.94318014
20EIF2AK11.93494083
21GRK11.86714670
22CDK191.79131288
23WEE11.73959520
24PIM21.73402072
25TLK11.70243374
26NME21.66482337
27PLK41.63556652
28TSSK61.59720198
29MINK11.57882643
30DAPK11.52705349
31NTRK31.52561206
32MAP3K111.50785507
33GRK51.49077404
34RIPK41.45963775
35PBK1.44533602
36PINK11.43126571
37EIF2AK31.30687454
38CSNK1G11.26631424
39ACVR1B1.24907107
40ERBB31.19950398
41WNK41.19671668
42MAP3K41.19197893
43MAP3K91.19069289
44TXK1.18883623
45CSNK1A1L1.18769822
46PNCK1.18535736
47BCR1.17880281
48INSRR1.17772446
49CAMKK21.16663354
50DAPK21.14743791
51PRPF4B1.12653501
52PRKCG1.09682587
53SIK31.09547772
54BMPR21.08982066
55TIE11.05137001
56KDR1.01738217
57MUSK1.00092215
58MYLK0.98441849
59MAPKAPK30.98326348
60LIMK10.98134157
61PDK40.96682349
62PDK30.96682349
63BRSK10.95120271
64OXSR10.94137144
65NEK20.92107243
66MAP2K40.90885463
67RAF10.88482149
68AURKA0.88321476
69CAMK2G0.87806971
70CAMK2B0.87688632
71BCKDK0.85160047
72MARK10.84981189
73STK390.84953640
74PLK30.81859391
75MKNK20.80878343
76TNIK0.78626814
77MST40.78471096
78SRPK10.76367018
79CDC70.76165296
80PAK30.74331361
81CAMK2A0.73072661
82OBSCN0.72157887
83TESK10.72035570
84ABL20.71829721
85MKNK10.71350742
86BRSK20.69530728
87TESK20.68345937
88RPS6KA50.67854661
89CDK140.64943725
90CAMK2D0.62370412
91PDK20.62328297
92VRK10.62192605
93CDK180.60017227
94KSR10.57743500
95TTK0.56705533
96CSNK1G20.54991035
97DYRK30.54952860
98DAPK30.53999483
99ZAK0.53987305
100MAPK130.53786300
101CDK80.53745781
102CSNK1G30.53647095
103CDK150.51254307
104EPHA20.50893959
105TAOK30.50678187
106PRKCI0.50580811
107CSNK1A10.49222369
108ADRBK20.48701599
109PLK10.48517746
110MAPKAPK50.48216357
111PRKCE0.47437747
112MAP2K60.47226934
113CDK11A0.47114350
114AURKB0.46272669
115STK38L0.45912272
116GRK70.45892881
117ATR0.45628963
118EIF2AK20.44127455
119STK240.43239214
120RPS6KA40.43031641
121PKN10.39885224
122CDK50.39275667
123BMPR1B0.39150302
124ADRBK10.38661284
125ILK0.38195092
126CSNK2A10.38095087
127LMTK20.37083455
128MAP2K10.36845684
129PHKG20.36606598
130PHKG10.36606598
131DYRK20.36160666
132TNK20.34896118
133NTRK10.33742957
134KSR20.31603046
135CSNK2A20.30810908
136PRKACA0.30279485

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.03864897
2Proteasome_Homo sapiens_hsa030504.77118941
3Parkinsons disease_Homo sapiens_hsa050124.19712524
4Alzheimers disease_Homo sapiens_hsa050103.17797090
5Collecting duct acid secretion_Homo sapiens_hsa049663.09347847
6Huntingtons disease_Homo sapiens_hsa050163.07763550
7RNA polymerase_Homo sapiens_hsa030203.03541619
8Synaptic vesicle cycle_Homo sapiens_hsa047212.97674614
9Ribosome_Homo sapiens_hsa030102.39076549
10Nicotine addiction_Homo sapiens_hsa050332.28365312
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.18666004
12Cardiac muscle contraction_Homo sapiens_hsa042602.11789155
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04829974
14Vibrio cholerae infection_Homo sapiens_hsa051101.97247252
15Vitamin B6 metabolism_Homo sapiens_hsa007501.90048077
16Protein export_Homo sapiens_hsa030601.84873093
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83826134
18Olfactory transduction_Homo sapiens_hsa047401.65297988
19Pyrimidine metabolism_Homo sapiens_hsa002401.62594869
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57338326
21Propanoate metabolism_Homo sapiens_hsa006401.54199742
22Phototransduction_Homo sapiens_hsa047441.45955130
23Regulation of autophagy_Homo sapiens_hsa041401.39315515
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36332087
25One carbon pool by folate_Homo sapiens_hsa006701.30689188
26Fanconi anemia pathway_Homo sapiens_hsa034601.30475676
27GABAergic synapse_Homo sapiens_hsa047271.23827307
28Non-homologous end-joining_Homo sapiens_hsa034501.21039437
29Purine metabolism_Homo sapiens_hsa002301.19895530
30Amphetamine addiction_Homo sapiens_hsa050311.11575916
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11276508
32RNA transport_Homo sapiens_hsa030131.10182679
33Selenocompound metabolism_Homo sapiens_hsa004501.09926377
34Taste transduction_Homo sapiens_hsa047421.09878163
35Long-term potentiation_Homo sapiens_hsa047201.07127207
36Nitrogen metabolism_Homo sapiens_hsa009101.04440954
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.03162295
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00230936
39Circadian entrainment_Homo sapiens_hsa047130.99372310
40Rheumatoid arthritis_Homo sapiens_hsa053230.99082691
41Caffeine metabolism_Homo sapiens_hsa002320.98652705
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97864175
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96971947
44Fructose and mannose metabolism_Homo sapiens_hsa000510.96567554
45Spliceosome_Homo sapiens_hsa030400.96120914
46Tryptophan metabolism_Homo sapiens_hsa003800.95202481
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94283273
48Morphine addiction_Homo sapiens_hsa050320.93690081
49Folate biosynthesis_Homo sapiens_hsa007900.91839726
50Pyruvate metabolism_Homo sapiens_hsa006200.90604114
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89045910
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88951398
53Linoleic acid metabolism_Homo sapiens_hsa005910.88834139
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88784556
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84985692
56Sulfur relay system_Homo sapiens_hsa041220.84923730
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84727169
58Dopaminergic synapse_Homo sapiens_hsa047280.84716547
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.81003240
60Serotonergic synapse_Homo sapiens_hsa047260.80892547
61Mismatch repair_Homo sapiens_hsa034300.80523348
62Steroid biosynthesis_Homo sapiens_hsa001000.80064407
63Nucleotide excision repair_Homo sapiens_hsa034200.80022965
64Metabolic pathways_Homo sapiens_hsa011000.78983696
65Chemical carcinogenesis_Homo sapiens_hsa052040.78517118
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78415384
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78321089
68DNA replication_Homo sapiens_hsa030300.78290975
69Oocyte meiosis_Homo sapiens_hsa041140.76462870
70Basal transcription factors_Homo sapiens_hsa030220.75946370
71Glutamatergic synapse_Homo sapiens_hsa047240.75286025
72Carbon metabolism_Homo sapiens_hsa012000.74179657
73beta-Alanine metabolism_Homo sapiens_hsa004100.72538404
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71988927
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71219007
76Sulfur metabolism_Homo sapiens_hsa009200.71187628
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70318056
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70243001
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70182056
80Calcium signaling pathway_Homo sapiens_hsa040200.66940872
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66819494
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66427158
83Salivary secretion_Homo sapiens_hsa049700.66354121
84Fatty acid elongation_Homo sapiens_hsa000620.66233043
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.66218070
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64130235
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63576159
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62203306
89Homologous recombination_Homo sapiens_hsa034400.61279623
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60728350
91Fatty acid metabolism_Homo sapiens_hsa012120.59769358
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59708541
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57917434
94Biosynthesis of amino acids_Homo sapiens_hsa012300.57757857
95Pentose phosphate pathway_Homo sapiens_hsa000300.57370558
96Ether lipid metabolism_Homo sapiens_hsa005650.54697798
97Fatty acid degradation_Homo sapiens_hsa000710.53620308
98Phagosome_Homo sapiens_hsa041450.53544830
99Retinol metabolism_Homo sapiens_hsa008300.51059915
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48561165
101Insulin secretion_Homo sapiens_hsa049110.48342198
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45965217
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.45442162
104Arachidonic acid metabolism_Homo sapiens_hsa005900.44497969
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42642421
106Long-term depression_Homo sapiens_hsa047300.40060315
107N-Glycan biosynthesis_Homo sapiens_hsa005100.37821203
108Type I diabetes mellitus_Homo sapiens_hsa049400.37230369
109Epstein-Barr virus infection_Homo sapiens_hsa051690.36973139
110Cholinergic synapse_Homo sapiens_hsa047250.36653029
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36304333
112Gastric acid secretion_Homo sapiens_hsa049710.35857517
113Base excision repair_Homo sapiens_hsa034100.34879740
114RNA degradation_Homo sapiens_hsa030180.34505200
115Glutathione metabolism_Homo sapiens_hsa004800.34369025
116Fat digestion and absorption_Homo sapiens_hsa049750.34144178
117Oxytocin signaling pathway_Homo sapiens_hsa049210.31113644
118Tyrosine metabolism_Homo sapiens_hsa003500.30857791
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.30850887
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29682278
121Asthma_Homo sapiens_hsa053100.25972699
122Galactose metabolism_Homo sapiens_hsa000520.24636471
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.22947545
124Renin secretion_Homo sapiens_hsa049240.22666713
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22205651
126Sphingolipid metabolism_Homo sapiens_hsa006000.21469903
127Butanoate metabolism_Homo sapiens_hsa006500.20946972
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20061713
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18840358
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18295092
131Gap junction_Homo sapiens_hsa045400.18015177
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17234387
133Arginine and proline metabolism_Homo sapiens_hsa003300.16749671
134Peroxisome_Homo sapiens_hsa041460.16550098
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.16311694
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15826171
137Circadian rhythm_Homo sapiens_hsa047100.15765105

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