EMC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.99055104
2fatty acid elongation (GO:0030497)4.80505617
3neutrophil activation involved in immune response (GO:0002283)4.39086757
4pyrimidine-containing compound transmembrane transport (GO:0072531)4.37605174
5vitamin transmembrane transport (GO:0035461)4.24074081
6L-serine metabolic process (GO:0006563)4.21205572
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15937807
8biotin metabolic process (GO:0006768)4.07572524
9alpha-linolenic acid metabolic process (GO:0036109)3.96101853
10long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.93235651
11thioester biosynthetic process (GO:0035384)3.90587613
12acyl-CoA biosynthetic process (GO:0071616)3.90587613
13cholesterol biosynthetic process (GO:0006695)3.90498973
14folic acid transport (GO:0015884)3.84235535
15fatty-acyl-CoA biosynthetic process (GO:0046949)3.80102903
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76949089
17respiratory electron transport chain (GO:0022904)3.70323655
18electron transport chain (GO:0022900)3.70294280
19heme transport (GO:0015886)3.67075744
20DNA deamination (GO:0045006)3.60296187
21ATP synthesis coupled proton transport (GO:0015986)3.58288960
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58288960
23autophagic vacuole fusion (GO:0000046)3.55977906
24protein complex biogenesis (GO:0070271)3.49050037
25serine family amino acid biosynthetic process (GO:0009070)3.48605565
26pantothenate metabolic process (GO:0015939)3.47620409
27sterol biosynthetic process (GO:0016126)3.47060282
28triglyceride biosynthetic process (GO:0019432)3.46066577
29cofactor transport (GO:0051181)3.44866234
30CDP-diacylglycerol metabolic process (GO:0046341)3.39776267
31proteasome assembly (GO:0043248)3.37360814
32NADH metabolic process (GO:0006734)3.34797510
33creatine metabolic process (GO:0006600)3.29581398
34neutral lipid biosynthetic process (GO:0046460)3.27841931
35acylglycerol biosynthetic process (GO:0046463)3.27841931
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.26409079
37NADH dehydrogenase complex assembly (GO:0010257)3.26409079
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26409079
39adhesion of symbiont to host (GO:0044406)3.23985131
40negative regulation of heart rate (GO:0010459)3.23520339
41regulation of cholesterol metabolic process (GO:0090181)3.21571834
42L-methionine salvage (GO:0071267)3.20113145
43L-methionine biosynthetic process (GO:0071265)3.20113145
44amino acid salvage (GO:0043102)3.20113145
45purine-containing compound salvage (GO:0043101)3.20036180
46negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.19040874
47fatty-acyl-CoA metabolic process (GO:0035337)3.18614848
48adhesion of symbiont to host cell (GO:0044650)3.17149531
49virion attachment to host cell (GO:0019062)3.17149531
50xenobiotic catabolic process (GO:0042178)3.15682725
51platelet dense granule organization (GO:0060155)3.13067899
52long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.11851480
53mitochondrial respiratory chain complex assembly (GO:0033108)3.10589244
54organelle membrane fusion (GO:0090174)3.05086527
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.04039114
56negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.01775722
57serine family amino acid metabolic process (GO:0009069)2.98916142
58axon ensheathment in central nervous system (GO:0032291)2.98207498
59central nervous system myelination (GO:0022010)2.98207498
60very long-chain fatty acid metabolic process (GO:0000038)2.98175605
61cytidine metabolic process (GO:0046087)2.96786581
62cytidine catabolic process (GO:0006216)2.96786581
63cytidine deamination (GO:0009972)2.96786581
64cysteine metabolic process (GO:0006534)2.96026449
65acetyl-CoA metabolic process (GO:0006084)2.94653341
66regulation of cholesterol biosynthetic process (GO:0045540)2.94529146
67branched-chain amino acid catabolic process (GO:0009083)2.94232651
68serine family amino acid catabolic process (GO:0009071)2.94225037
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93383742
70granulocyte activation (GO:0036230)2.92343566
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91873618
72L-phenylalanine catabolic process (GO:0006559)2.91873618
73regulation of platelet activation (GO:0010543)2.91737279
74modified amino acid transport (GO:0072337)2.91424754
75opsonization (GO:0008228)2.91206260
76neutrophil activation (GO:0042119)2.90702860
77acyl-CoA metabolic process (GO:0006637)2.90252719
78thioester metabolic process (GO:0035383)2.90252719
79sulfur amino acid catabolic process (GO:0000098)2.88898266
80glycine metabolic process (GO:0006544)2.88530227
81thrombin receptor signaling pathway (GO:0070493)2.87933539
82respiratory chain complex IV assembly (GO:0008535)2.87083015
83NADPH regeneration (GO:0006740)2.86840188
84nucleotide transmembrane transport (GO:1901679)2.83715342
85L-phenylalanine metabolic process (GO:0006558)2.82685230
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82685230
87valine metabolic process (GO:0006573)2.82604277
88cytochrome complex assembly (GO:0017004)2.82271428
89response to mercury ion (GO:0046689)2.82133243
90positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.80786998
91linoleic acid metabolic process (GO:0043651)2.79848432
92hydrogen ion transmembrane transport (GO:1902600)2.78831597
93lipoxygenase pathway (GO:0019372)2.78776751
94regulation of oxidative phosphorylation (GO:0002082)2.78755755
95regulation of integrin-mediated signaling pathway (GO:2001044)2.78543471
96plasma lipoprotein particle clearance (GO:0034381)2.77833859
97amine catabolic process (GO:0009310)2.76044958
98cellular biogenic amine catabolic process (GO:0042402)2.76044958
99pyrimidine nucleoside catabolic process (GO:0046135)2.75580972
100low-density lipoprotein particle clearance (GO:0034383)2.74618951
101pentose-phosphate shunt (GO:0006098)2.73653979
102regulation of platelet aggregation (GO:0090330)2.72171796
103CDP-diacylglycerol biosynthetic process (GO:0016024)2.72088729
104positive regulation of triglyceride metabolic process (GO:0090208)2.71936219
105regulation of cellular amino acid metabolic process (GO:0006521)2.70164327
106positive regulation of mast cell activation (GO:0033005)2.69028269
107phosphatidic acid biosynthetic process (GO:0006654)2.67869114
108phosphatidic acid metabolic process (GO:0046473)2.67869114
109phagocytosis, recognition (GO:0006910)2.67344880
110ATP hydrolysis coupled proton transport (GO:0015991)2.67157171
111energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.67157171
112L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66718118
113iron coordination entity transport (GO:1901678)2.66480682
114positive regulation of triglyceride biosynthetic process (GO:0010867)2.63958426
115purine nucleobase biosynthetic process (GO:0009113)2.62890078
116phagosome maturation (GO:0090382)2.62462100
117type B pancreatic cell proliferation (GO:0044342)2.61711708
118dopamine transport (GO:0015872)2.60882925
119glyoxylate metabolic process (GO:0046487)2.60554767
120purinergic nucleotide receptor signaling pathway (GO:0035590)2.60536527
121regulation of metalloenzyme activity (GO:0048552)2.59973355
122proton transport (GO:0015992)2.59238156
123short-chain fatty acid metabolic process (GO:0046459)2.59047609
124regulation of sequestering of triglyceride (GO:0010889)2.57191663
125negative regulation of macroautophagy (GO:0016242)2.55609450
126triglyceride metabolic process (GO:0006641)2.55582556
127ensheathment of neurons (GO:0007272)2.55056289
128axon ensheathment (GO:0008366)2.55056289
129folic acid metabolic process (GO:0046655)2.55042616
130branched-chain amino acid metabolic process (GO:0009081)2.55041480
131isoprenoid biosynthetic process (GO:0008299)2.54174881
132urate metabolic process (GO:0046415)2.53652458
133myelination (GO:0042552)2.53314872
134hydrogen transport (GO:0006818)2.53034440
135glycosylceramide metabolic process (GO:0006677)2.52498046
136ethanol oxidation (GO:0006069)2.51668941
137cellular response to cholesterol (GO:0071397)2.51574187
138reverse cholesterol transport (GO:0043691)2.50420942
139autophagic vacuole assembly (GO:0000045)2.49555482
140purine nucleotide salvage (GO:0032261)2.49445945
141mitochondrial calcium ion homeostasis (GO:0051560)2.49134388
142positive regulation of triglyceride lipase activity (GO:0061365)2.48554955
143positive regulation of lipoprotein lipase activity (GO:0051006)2.48554955
144mitochondrial calcium ion transport (GO:0006851)2.48428112
145antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.48168374
146negative regulation of appetite (GO:0032099)2.46862904
147negative regulation of response to food (GO:0032096)2.46862904
148adenosine metabolic process (GO:0046085)2.46780903
149fatty acid beta-oxidation (GO:0006635)2.46624661
150vitamin transport (GO:0051180)2.45315294
151bile acid biosynthetic process (GO:0006699)2.45056483
152L-serine transport (GO:0015825)2.44194236
153amino-acid betaine metabolic process (GO:0006577)2.43713576
154fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.42849106
155superoxide anion generation (GO:0042554)2.42538789
156oxygen transport (GO:0015671)2.42513498
157antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.42402341
158negative regulation of response to reactive oxygen species (GO:1901032)2.42356847
159protein-cofactor linkage (GO:0018065)2.40017542
160pyrimidine ribonucleoside catabolic process (GO:0046133)2.38356826
161signal peptide processing (GO:0006465)2.38027195
162establishment of protein localization to mitochondrial membrane (GO:0090151)2.36814527
163leukocyte migration involved in inflammatory response (GO:0002523)2.36609658
164response to xenobiotic stimulus (GO:0009410)2.34715781
165regulation of macrophage derived foam cell differentiation (GO:0010743)2.34587870
166fusion of sperm to egg plasma membrane (GO:0007342)2.33939142
167response to interferon-beta (GO:0035456)2.33523516
168regulation of mast cell activation (GO:0033003)2.33225987
169leukocyte degranulation (GO:0043299)2.32069344
170heme metabolic process (GO:0042168)2.31452193
171G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.31250778
172DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.26717909
173eosinophil chemotaxis (GO:0048245)2.24596081
174phospholipid homeostasis (GO:0055091)2.23828358
175aromatic amino acid family catabolic process (GO:0009074)2.23749613
176ATP biosynthetic process (GO:0006754)2.23039238
177negative regulation of thymocyte apoptotic process (GO:0070244)2.22425546
178negative regulation of calcium ion transmembrane transport (GO:1903170)2.22408558
179negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.22408558
180protein deneddylation (GO:0000338)2.21541082
181blood coagulation, intrinsic pathway (GO:0007597)2.21239770
182cellular metabolic compound salvage (GO:0043094)2.20383429
183porphyrin-containing compound metabolic process (GO:0006778)2.20361519
184low-density lipoprotein particle remodeling (GO:0034374)2.19279288
185glutathione derivative metabolic process (GO:1901685)2.18857386
186glutathione derivative biosynthetic process (GO:1901687)2.18857386
187tyrosine metabolic process (GO:0006570)2.18786822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.57189402
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.31161423
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.58064737
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.55487045
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35390624
6CLOCK_20551151_ChIP-Seq_293T_Human3.15209046
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.09751923
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01914471
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.00156130
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.96316464
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.84157597
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.71193468
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66098362
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65449977
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.58708821
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57465498
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48805768
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.45684651
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45031539
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.35876341
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.33993640
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.30008294
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.23787956
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.20777280
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14936701
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13864383
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13535513
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09665395
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.08507936
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04999537
31EGR1_23403033_ChIP-Seq_LIVER_Mouse2.00863424
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89277359
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.88103237
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87407527
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.87239447
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86442575
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84731794
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.82639262
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81266884
40GATA1_22025678_ChIP-Seq_K562_Human1.77619328
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76393326
42VDR_22108803_ChIP-Seq_LS180_Human1.72924264
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72299673
44ELK1_19687146_ChIP-ChIP_HELA_Human1.72249053
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71729472
46SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.71238316
47ZNF263_19887448_ChIP-Seq_K562_Human1.70110208
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67838673
49AR_21909140_ChIP-Seq_LNCAP_Human1.58582975
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.58469458
51GATA1_19941826_ChIP-Seq_K562_Human1.53425602
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50304926
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46588993
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.46322431
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43889633
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43769803
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43669899
58EOMES_21245162_ChIP-Seq_HESCs_Human1.42971631
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42042424
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41709399
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40601205
62* SPI1_23547873_ChIP-Seq_NB4_Human1.40407756
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.39723542
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39161197
65FOXP3_21729870_ChIP-Seq_TREG_Human1.39018184
66TP53_22573176_ChIP-Seq_HFKS_Human1.37476826
67TFEB_21752829_ChIP-Seq_HELA_Human1.36740719
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36440385
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34380923
70DCP1A_22483619_ChIP-Seq_HELA_Human1.33790854
71STAT1_20625510_ChIP-Seq_HELA_Human1.33746255
72GATA3_26560356_Chip-Seq_TH2_Human1.28054324
73SALL4_22934838_ChIP-ChIP_CD34+_Human1.26847269
74AR_20517297_ChIP-Seq_VCAP_Human1.26838971
75GATA2_19941826_ChIP-Seq_K562_Human1.25714499
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.25532066
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.25398799
78ER_23166858_ChIP-Seq_MCF-7_Human1.23751879
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.22980541
80SPI1_23127762_ChIP-Seq_K562_Human1.22344609
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20858210
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20720120
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20228090
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19051657
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.18880586
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18356878
87SCL_19346495_ChIP-Seq_HPC-7_Human1.17852689
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17219501
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16624016
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15276351
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14135348
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13506755
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.13463934
94E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12710599
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12444547
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12444547
97PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.11515903
98GABP_19822575_ChIP-Seq_HepG2_Human1.11453477
99TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10241582
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10207104
101GBX2_23144817_ChIP-Seq_PC3_Human1.09933577
102VDR_23849224_ChIP-Seq_CD4+_Human1.08729081
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08609838
104ERG_20517297_ChIP-Seq_VCAP_Human1.08060673
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.07464035
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07464035
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05504948
108SOX2_19829295_ChIP-Seq_ESCs_Human1.04882487
109NANOG_19829295_ChIP-Seq_ESCs_Human1.04882487
110SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02449530
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01306962
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00944648
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99658938
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98928423
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98658712
116FOXH1_21741376_ChIP-Seq_ESCs_Human0.98280336
117SOX2_20726797_ChIP-Seq_SW620_Human0.97894707
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97894561
119KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.97175677
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97106671
121SOX17_20123909_ChIP-Seq_XEN_Mouse0.96655722
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96392430
123ZNF274_21170338_ChIP-Seq_K562_Hela0.96279890
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.94455609
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94279975
126GATA6_21074721_ChIP-Seq_CACO-2_Human0.94178710
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93619611
128NANOG_20526341_ChIP-Seq_ESCs_Human0.93490823
129GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93222970
130SPI1_20517297_ChIP-Seq_HL60_Human0.91899205
131JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91772849
132HTT_18923047_ChIP-ChIP_STHdh_Human0.91299154
133THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90950290
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90018479
135RBPJ_21746931_ChIP-Seq_IB4_Human0.89663508
136ELK3_25401928_ChIP-Seq_HUVEC_Human0.88127307
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87898592
138FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87377865
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.86937420
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86760447
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85656038
142NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85612642
143MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85504125
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85200576
145CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83839686
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83800467
147RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83224514
148GATA4_25053715_ChIP-Seq_YYC3_Human0.82572591
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82257351
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81854194
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81486821
152P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80566994
153TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80550978
154FLI1_21867929_ChIP-Seq_CD8_Mouse0.80391494
155MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.80274717
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.78980021
157NELFA_20434984_ChIP-Seq_ESCs_Mouse0.78431930
158CTCF_20526341_ChIP-Seq_ESCs_Human0.77607866
159CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76714097
160MYB_21317192_ChIP-Seq_ERMYB_Mouse0.76569327
161ATF3_27146783_Chip-Seq_COLON_Human0.76511051
162TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.76357615
163SMC3_22415368_ChIP-Seq_MEFs_Mouse0.74654710
164CJUN_26792858_Chip-Seq_BT549_Human0.74498216
165FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73949487
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.73649679
167SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73160770
168SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72422766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.56373614
2MP0009840_abnormal_foam_cell4.46155059
3MP0008438_abnormal_cutaneous_collagen4.42960909
4MP0003806_abnormal_nucleotide_metabolis3.45545815
5MP0003329_amyloid_beta_deposits3.35535469
6MP0005058_abnormal_lysosome_morphology3.33679365
7MP0002139_abnormal_hepatobiliary_system2.72166951
8MP0000604_amyloidosis2.53270561
9MP0001542_abnormal_bone_strength2.45620996
10MP0000920_abnormal_myelination2.43280808
11MP0005332_abnormal_amino_acid2.43128948
12MP0005671_abnormal_response_to2.41962584
13MP0001661_extended_life_span2.40852254
14MP0002148_abnormal_hypersensitivity_rea2.38856676
15MP0003690_abnormal_glial_cell2.31877006
16MP0001835_abnormal_antigen_presentation2.30942210
17MP0005360_urolithiasis2.30712499
18MP0003656_abnormal_erythrocyte_physiolo2.24271578
19MP0008260_abnormal_autophagy2.20857243
20MP0003186_abnormal_redox_activity2.01776272
21MP0003191_abnormal_cellular_cholesterol1.99973163
22MP0008004_abnormal_stomach_pH1.99638760
23MP0009785_altered_susceptibility_to1.97709467
24MP0005451_abnormal_body_composition1.95665830
25MP0001958_emphysema1.82091518
26MP0009384_cardiac_valve_regurgitation1.80951848
27MP0002876_abnormal_thyroid_physiology1.80711159
28MP0010329_abnormal_lipoprotein_level1.80511171
29MP0009764_decreased_sensitivity_to1.70514796
30MP0003646_muscle_fatigue1.69313382
31MP0005365_abnormal_bile_salt1.67603854
32MP0005503_abnormal_tendon_morphology1.64693413
33MP0003718_maternal_effect1.63556856
34MP0003195_calcinosis1.60557137
35MP0004147_increased_porphyrin_level1.56459280
36MP0005000_abnormal_immune_tolerance1.55281063
37MP0003950_abnormal_plasma_membrane1.53900300
38MP0006082_CNS_inflammation1.52913155
39MP0002295_abnormal_pulmonary_circulatio1.52823761
40MP0003279_aneurysm1.51507450
41MP0010386_abnormal_urinary_bladder1.50987058
42MP0005275_abnormal_skin_tensile1.49250200
43MP0008875_abnormal_xenobiotic_pharmacok1.47940250
44MP0005085_abnormal_gallbladder_physiolo1.45694842
45MP0002118_abnormal_lipid_homeostasis1.45489418
46MP0002837_dystrophic_cardiac_calcinosis1.44476058
47MP0005584_abnormal_enzyme/coenzyme_acti1.42754199
48MP0000747_muscle_weakness1.42584313
49MP0005171_absent_coat_pigmentation1.41499548
50MP0003724_increased_susceptibility_to1.40500897
51MP0005410_abnormal_fertilization1.39218141
52MP0008872_abnormal_physiological_respon1.36626126
53MP0000685_abnormal_immune_system1.35162953
54MP0002723_abnormal_immune_serum1.35044780
55MP0005025_abnormal_response_to1.33636735
56MP0004130_abnormal_muscle_cell1.32078774
57MP0002736_abnormal_nociception_after1.31958559
58MP0004885_abnormal_endolymph1.29709001
59MP0001790_abnormal_immune_system1.29420858
60MP0005387_immune_system_phenotype1.29420858
61MP0000015_abnormal_ear_pigmentation1.28108397
62MP0005084_abnormal_gallbladder_morpholo1.28091503
63MP0005408_hypopigmentation1.27964466
64MP0000343_altered_response_to1.27114387
65MP0002132_abnormal_respiratory_system1.26807836
66MP0003303_peritoneal_inflammation1.26096533
67MP0002452_abnormal_antigen_presenting1.26022236
68MP0001845_abnormal_inflammatory_respons1.25531728
69MP0009643_abnormal_urine_homeostasis1.24551797
70MP0005319_abnormal_enzyme/_coenzyme1.23755113
71MP0003634_abnormal_glial_cell1.23008353
72MP0010155_abnormal_intestine_physiology1.22866302
73MP0003436_decreased_susceptibility_to1.21938158
74MP0000609_abnormal_liver_physiology1.20948735
75MP0005167_abnormal_blood-brain_barrier1.20866607
76MP0003705_abnormal_hypodermis_morpholog1.20625728
77MP0001800_abnormal_humoral_immune1.20310433
78MP0005164_abnormal_response_to1.19059618
79MP0006054_spinal_hemorrhage1.18777850
80MP0006036_abnormal_mitochondrial_physio1.15408416
81MP0005075_abnormal_melanosome_morpholog1.15267883
82MP0002420_abnormal_adaptive_immunity1.12581876
83MP0004272_abnormal_basement_membrane1.12338622
84MP0004510_myositis1.11832767
85MP0001819_abnormal_immune_cell1.11073376
86MP0000230_abnormal_systemic_arterial1.11054673
87MP0001533_abnormal_skeleton_physiology1.10552284
88MP0004019_abnormal_vitamin_homeostasis1.08690700
89MP0002090_abnormal_vision1.08265987
90MP0009763_increased_sensitivity_to1.07887170
91MP0003221_abnormal_cardiomyocyte_apopto1.07808381
92MP0005174_abnormal_tail_pigmentation1.06230669
93MP0001756_abnormal_urination1.05745238
94MP0003866_abnormal_defecation1.04632666
95MP0004858_abnormal_nervous_system1.00493107
96MP0005646_abnormal_pituitary_gland0.98628824
97MP0001968_abnormal_touch/_nociception0.97433139
98MP0009765_abnormal_xenobiotic_induced0.96953820
99MP0008775_abnormal_heart_ventricle0.96914784
100MP0003638_abnormal_response/metabolism_0.96541055
101MP0004142_abnormal_muscle_tone0.95972227
102MP0003172_abnormal_lysosome_physiology0.95813921
103MP0009333_abnormal_splenocyte_physiolog0.95513157
104MP0005330_cardiomyopathy0.95247151
105MP0000750_abnormal_muscle_regeneration0.95005766
106MP0004215_abnormal_myocardial_fiber0.92909085
107MP0005595_abnormal_vascular_smooth0.92482753
108MP0002332_abnormal_exercise_endurance0.91748608
109MP0001545_abnormal_hematopoietic_system0.91705127
110MP0005397_hematopoietic_system_phenotyp0.91705127
111MP0003878_abnormal_ear_physiology0.90827231
112MP0005377_hearing/vestibular/ear_phenot0.90827231
113MP0001853_heart_inflammation0.90478828
114MP0000647_abnormal_sebaceous_gland0.89950085
115MP0005636_abnormal_mineral_homeostasis0.89740090
116MP0003075_altered_response_to0.89563580
117MP0005395_other_phenotype0.88589628
118MP0000358_abnormal_cell_content/0.88071857
119MP0005310_abnormal_salivary_gland0.88060946
120MP0002269_muscular_atrophy0.87542003
121MP0000689_abnormal_spleen_morphology0.86190802
122MP0003879_abnormal_hair_cell0.85958610
123MP0005535_abnormal_body_temperature0.85508600
124MP0002398_abnormal_bone_marrow0.85218414
125MP0002933_joint_inflammation0.84794461
126MP0004084_abnormal_cardiac_muscle0.84662060
127MP0004036_abnormal_muscle_relaxation0.84527764
128MP0008469_abnormal_protein_level0.82186876
129MP0001881_abnormal_mammary_gland0.81856767
130MP0000465_gastrointestinal_hemorrhage0.81664402
131MP0003632_abnormal_nervous_system0.81268055
132MP0001764_abnormal_homeostasis0.80302719
133MP0000372_irregular_coat_pigmentation0.79761182
134MP0001663_abnormal_digestive_system0.79742459
135MP0006138_congestive_heart_failure0.79165131
136MP0002419_abnormal_innate_immunity0.78639969
137MP0000749_muscle_degeneration0.78502163
138MP0000249_abnormal_blood_vessel0.77265311
139MP0003011_delayed_dark_adaptation0.76103916
140MP0001905_abnormal_dopamine_level0.75386791
141MP0001666_abnormal_nutrient_absorption0.74039946
142MP0005670_abnormal_white_adipose0.74017617
143MP0004185_abnormal_adipocyte_glucose0.73421150
144MP0004883_abnormal_blood_vessel0.72846891
145MP0000013_abnormal_adipose_tissue0.70600070
146MP0006035_abnormal_mitochondrial_morpho0.70396905
147MP0001243_abnormal_dermal_layer0.70055496
148MP0002971_abnormal_brown_adipose0.68842714
149MP0000598_abnormal_liver_morphology0.68815950
150MP0005666_abnormal_adipose_tissue0.68771059
151MP0005508_abnormal_skeleton_morphology0.66438453
152MP0002136_abnormal_kidney_physiology0.65999091
153MP0005083_abnormal_biliary_tract0.64619727
154MP0004134_abnormal_chest_morphology0.64428245
155MP0005165_increased_susceptibility_to0.63796271
156MP0005390_skeleton_phenotype0.63700957

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.31196207
2Premature rupture of membranes (HP:0001788)4.82668123
3Prolonged bleeding time (HP:0003010)4.63408116
43-Methylglutaconic aciduria (HP:0003535)4.52694271
5Neurofibrillary tangles (HP:0002185)4.47889854
6Hyperglycinemia (HP:0002154)4.16018115
7Acute necrotizing encephalopathy (HP:0006965)4.08946537
8Hyperglycinuria (HP:0003108)4.02775130
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.93767383
10Abnormality of serine family amino acid metabolism (HP:0010894)3.90601843
11Abnormality of glycine metabolism (HP:0010895)3.90601843
12Abnormal mitochondria in muscle tissue (HP:0008316)3.79217010
13Mitochondrial inheritance (HP:0001427)3.74585362
14Generalized aminoaciduria (HP:0002909)3.64976038
15Acute encephalopathy (HP:0006846)3.61171286
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.57528592
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.57528592
18Progressive macrocephaly (HP:0004481)3.52989370
19Menorrhagia (HP:0000132)3.42910344
20Increased mean platelet volume (HP:0011877)3.37569323
21Renal Fanconi syndrome (HP:0001994)3.35012224
22Cerebral inclusion bodies (HP:0100314)3.33975762
23Increased CSF lactate (HP:0002490)3.33407128
24Xanthomatosis (HP:0000991)3.26412607
25Epistaxis (HP:0000421)3.24565806
26Abnormal platelet volume (HP:0011876)3.20682859
27Increased serum pyruvate (HP:0003542)3.12444225
28Abnormality of glycolysis (HP:0004366)3.12444225
29Muscle fiber splitting (HP:0003555)2.99586277
30Paralysis (HP:0003470)2.92305100
31Gout (HP:0001997)2.91275052
32Gingival bleeding (HP:0000225)2.86864195
33Hyperlipoproteinemia (HP:0010980)2.83439824
34Osteolytic defects of the hand bones (HP:0009699)2.83426892
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.83426892
36Cerebral hypomyelination (HP:0006808)2.82668309
37Spastic paraparesis (HP:0002313)2.81142633
38Poikilocytosis (HP:0004447)2.80075323
39Exertional dyspnea (HP:0002875)2.78738743
40Protrusio acetabuli (HP:0003179)2.75376569
41Abnormality of fatty-acid metabolism (HP:0004359)2.74271027
42Increased intramyocellular lipid droplets (HP:0012240)2.71915189
43Stomatitis (HP:0010280)2.71736240
44Abnormality of serum amino acid levels (HP:0003112)2.69781599
45Cerebral edema (HP:0002181)2.55895593
46Increased muscle lipid content (HP:0009058)2.53755796
47Increased cerebral lipofuscin (HP:0011813)2.51897435
48Vacuolated lymphocytes (HP:0001922)2.50167512
49Lactic acidosis (HP:0003128)2.48951140
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.48808969
51Respiratory failure (HP:0002878)2.47666370
52Lipid accumulation in hepatocytes (HP:0006561)2.47201644
53Nonimmune hydrops fetalis (HP:0001790)2.45994289
54Increased hepatocellular lipid droplets (HP:0006565)2.45668469
55Paraparesis (HP:0002385)2.45207746
56Renal cortical cysts (HP:0000803)2.40744979
57Abnormality of the umbilical cord (HP:0010881)2.36942577
58Deep venous thrombosis (HP:0002625)2.36560725
59Prolonged neonatal jaundice (HP:0006579)2.35233336
60Hepatosplenomegaly (HP:0001433)2.35061420
61Abnormality of iron homeostasis (HP:0011031)2.34153182
62Hypochromic microcytic anemia (HP:0004840)2.33488861
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31469289
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31054753
65Dyschromatopsia (HP:0007641)2.30996907
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.30466920
67Cerebral hemorrhage (HP:0001342)2.30043505
68Vertebral compression fractures (HP:0002953)2.29824994
69Abnormal platelet function (HP:0011869)2.29381344
70Impaired platelet aggregation (HP:0003540)2.29381344
71Segmental peripheral demyelination/remyelination (HP:0003481)2.28120091
72Autoimmune hemolytic anemia (HP:0001890)2.26968121
73Abnormality of glycolipid metabolism (HP:0010969)2.26821903
74Abnormality of liposaccharide metabolism (HP:0010968)2.26821903
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.26821903
76Tongue fasciculations (HP:0001308)2.26565871
77Irregular epiphyses (HP:0010582)2.26529942
78Abnormality of transition element cation homeostasis (HP:0011030)2.25811572
79Axonal loss (HP:0003447)2.23177552
80Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22933463
81Increased IgM level (HP:0003496)2.22224398
82Hyperammonemia (HP:0001987)2.20864847
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20414823
84Abnormality of renal resorption (HP:0011038)2.16374554
85Increased serum lactate (HP:0002151)2.16072968
86Exercise intolerance (HP:0003546)2.15359011
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13968935
88Dicarboxylic aciduria (HP:0003215)2.13968935
89Dysostosis multiplex (HP:0000943)2.12710790
90Abnormal hemoglobin (HP:0011902)2.11589488
91Increased serum ferritin (HP:0003281)2.09150716
92Glycosuria (HP:0003076)2.08055079
93Abnormality of urine glucose concentration (HP:0011016)2.08055079
94Abnormal pupillary function (HP:0007686)2.07262377
95Muscle fibrillation (HP:0010546)2.06853507
96Abnormal delivery (HP:0001787)2.06436765
97CNS demyelination (HP:0007305)2.05794927
98Autoimmune thrombocytopenia (HP:0001973)2.04459012
99Lethargy (HP:0001254)2.03389879
100Abnormality of lateral ventricle (HP:0030047)2.03254667
101Ankle contracture (HP:0006466)2.01408925
102Global brain atrophy (HP:0002283)2.01398399
103Tetraplegia (HP:0002445)1.99159956
104Delusions (HP:0000746)1.99084441
105Congenital, generalized hypertrichosis (HP:0004540)1.98860848
106Hypothermia (HP:0002045)1.98846856
107Cervical subluxation (HP:0003308)1.94794711
108Microcytic anemia (HP:0001935)1.93263815
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93072499
110Autoamputation (HP:0001218)1.93065500
111Abnormality of alanine metabolism (HP:0010916)1.91936762
112Hyperalaninemia (HP:0003348)1.91936762
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91936762
114Short nail (HP:0001799)1.91620984
115Type I transferrin isoform profile (HP:0003642)1.90875617
116Calcaneovalgus deformity (HP:0001848)1.90755817
117Tinnitus (HP:0000360)1.88346262
118Methylmalonic aciduria (HP:0012120)1.87197630
119Hypobetalipoproteinemia (HP:0003563)1.86467633
120Abnormalities of placenta or umbilical cord (HP:0001194)1.86267048
121Deformed tarsal bones (HP:0008119)1.86087722
122Optic disc pallor (HP:0000543)1.84285439
123Hypoglycemic coma (HP:0001325)1.84185628
124Abnormality of the anterior horn cell (HP:0006802)1.83683935
125Degeneration of anterior horn cells (HP:0002398)1.83683935
126Abnormality of the renal cortex (HP:0011035)1.83177618
127Hypoalphalipoproteinemia (HP:0003233)1.83005651
128Congenital ichthyosiform erythroderma (HP:0007431)1.82171754
129Stridor (HP:0010307)1.81961482
130Obstructive lung disease (HP:0006536)1.81724763
131Chronic obstructive pulmonary disease (HP:0006510)1.81724763
132Polycythemia (HP:0001901)1.81717627
133Irritability (HP:0000737)1.81215983
134Hypolipoproteinemia (HP:0010981)1.80840035
135Biconcave vertebral bodies (HP:0004586)1.79751672
136Absent epiphyses (HP:0010577)1.77967051
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77967051
138Hepatic necrosis (HP:0002605)1.77690857
139Acanthocytosis (HP:0001927)1.76953195
140Elevated erythrocyte sedimentation rate (HP:0003565)1.76243013
141Encephalitis (HP:0002383)1.75833827
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75794149
143Recurrent abscess formation (HP:0002722)1.74974866
144Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.74517765
145Abnormal cartilage morphology (HP:0002763)1.72832870
146Flat capital femoral epiphysis (HP:0003370)1.72059605
147Split foot (HP:0001839)1.71037604
148Postnatal microcephaly (HP:0005484)1.70554284
149Albinism (HP:0001022)1.69653646
150Recurrent bacterial skin infections (HP:0005406)1.69419827
151Spastic tetraparesis (HP:0001285)1.68639761
152CNS hypomyelination (HP:0003429)1.68203812
153Epiphyseal stippling (HP:0010655)1.67209351
154Abnormality of purine metabolism (HP:0004352)1.66886885
155Abnormality of macrophages (HP:0004311)1.66548038
156Decreased central vision (HP:0007663)1.65749987
157Increased purine levels (HP:0004368)1.65431413
158Hyperuricemia (HP:0002149)1.65431413
159Stillbirth (HP:0003826)1.65406326
160Megalencephaly (HP:0001355)1.65214036
161Death in infancy (HP:0001522)1.64951130
162Peritonitis (HP:0002586)1.64670713
163X-linked dominant inheritance (HP:0001423)1.64415292
164Hepatocellular necrosis (HP:0001404)1.64257486
165Mitral stenosis (HP:0001718)1.63578097
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63575556
167Abnormality of the Achilles tendon (HP:0005109)1.63220602
168Joint swelling (HP:0001386)1.63008888
169Atrioventricular block (HP:0001678)1.62631086
170Intrahepatic cholestasis (HP:0001406)1.61612410
171Supranuclear gaze palsy (HP:0000605)1.61412462
172Nausea (HP:0002018)1.61184718
173Soft skin (HP:0000977)1.60960837
174Purpura (HP:0000979)1.59515935
175Opisthotonus (HP:0002179)1.59486712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.33642703
2STK393.28893573
3EIF2AK13.24155695
4BCKDK2.95756898
5TESK22.93082335
6NME22.88172154
7MAP3K122.80543819
8OXSR12.61060703
9TXK2.32175936
10PDK22.30678458
11ARAF2.26883254
12ADRBK22.26285782
13FRK2.25273927
14TAOK32.14423398
15PDK32.13078830
16PDK42.13078830
17EPHB12.00761623
18PIM21.94848812
19BMPR21.94212115
20TLK11.89434125
21KDR1.85726137
22MAP4K21.79395747
23PBK1.78805366
24LIMK11.78526357
25MAPKAPK31.77603790
26BMPR1B1.72086205
27TEC1.69451503
28TRIB31.67444509
29IKBKB1.61283594
30DDR21.55307877
31PINK11.52882733
32GRK51.50566986
33ABL21.49335349
34AKT31.40124343
35ERN11.38595128
36GRK61.34136378
37BLK1.31838278
38NEK11.30691056
39GRK11.29787377
40SYK1.23035265
41EIF2AK31.20383893
42PHKG11.19821167
43PHKG21.19821167
44CSNK1G31.19101537
45BTK1.18973348
46TIE11.16517128
47BMX1.15636299
48OBSCN1.15525116
49FGFR21.15460573
50TTN1.11573748
51BRAF1.11548523
52SIK11.10894990
53PLK21.10388909
54MAP3K31.07766389
55DAPK21.06993105
56GRK71.05279661
57WNK41.02522318
58ADRBK10.97232649
59ZAP700.96105811
60MAP2K60.95921356
61MOS0.95239138
62TRIM280.94838687
63LYN0.94237859
64LRRK20.94179228
65FES0.93096360
66LMTK20.92789813
67TAOK20.92672732
68VRK20.90938846
69TGFBR20.89450332
70CSF1R0.89389933
71CSNK1A1L0.89268266
72PDPK10.87747859
73CSNK1G10.87227477
74MYLK0.86301063
75PAK10.85989361
76CSNK1G20.85247549
77MAP2K30.84584226
78CDK190.83029197
79BCR0.82372697
80FGR0.81548244
81MAPK120.80618310
82MST1R0.80214008
83MARK30.78874221
84MET0.77591861
85MST40.77029039
86WEE10.75339623
87CAMK2G0.73732694
88HCK0.72913695
89KIT0.72474477
90ROCK20.72277845
91TNK20.71752595
92TSSK60.70580000
93MAP2K10.70510862
94STK30.70387862
95FER0.69323859
96IKBKE0.69145160
97IRAK10.69122502
98ILK0.69059335
99ICK0.68320178
100DYRK20.68185758
101DAPK10.67741370
102CAMKK20.67174258
103MAP3K50.66566000
104STK40.65961982
105PAK30.64495470
106ITK0.63671405
107NEK90.63631780
108VRK10.63542649
109IRAK30.61726934
110IRAK40.59823384
111PIK3CG0.58694559
112MAPKAPK50.58439955
113ZAK0.57949030
114MATK0.56944536
115LATS20.56936487
116EPHA20.56851352
117CDK140.56749930
118ACVR1B0.56041100
119INSRR0.55525573
120FGFR40.54965229
121KSR20.52913925
122NUAK10.51851840
123TRPM70.51695229
124EPHA30.51625738
125PAK40.51410920
126CSK0.51114355
127BRSK20.50534891
128PRKCI0.50110181
129NEK20.48894800
130SGK2230.48822837
131SGK4940.48822837
132RPS6KA50.48570170
133MAP3K110.48480428
134PRKCQ0.48228464
135ERBB30.47564256
136MAPK130.47210106
137CCNB10.46773155
138TESK10.46258391
139NME10.45987473
140TAOK10.45527940
141STK100.44015210
142CAMK2D0.43641596
143TBK10.43104194
144LATS10.42228822
145NTRK10.41563506
146SCYL20.41451316
147MUSK0.41330683
148CLK10.41048631
149RPS6KA40.40724934
150PRKCE0.39841992
151LCK0.39697759
152TYK20.39625252
153STK160.39458556
154PDK10.39337412
155DYRK30.39030694
156RIPK40.38923740
157DAPK30.38671047
158CAMK2B0.37531144
159PLK40.37103592
160PTK2B0.36898580

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.95936253
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.34196047
3Steroid biosynthesis_Homo sapiens_hsa001003.17148800
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.06584772
5Fatty acid elongation_Homo sapiens_hsa000622.95803621
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.81370635
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75830080
8Fatty acid metabolism_Homo sapiens_hsa012122.63462492
9Proteasome_Homo sapiens_hsa030502.43274597
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27985723
11SNARE interactions in vesicular transport_Homo sapiens_hsa041302.21911037
12Fatty acid degradation_Homo sapiens_hsa000712.20921385
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19892506
14Folate biosynthesis_Homo sapiens_hsa007902.03881237
15Propanoate metabolism_Homo sapiens_hsa006402.02581988
16Huntingtons disease_Homo sapiens_hsa050161.98816638
17Vitamin digestion and absorption_Homo sapiens_hsa049771.94033773
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.89991639
19Pentose phosphate pathway_Homo sapiens_hsa000301.84296832
20Butanoate metabolism_Homo sapiens_hsa006501.84004456
21Fatty acid biosynthesis_Homo sapiens_hsa000611.81209866
22Peroxisome_Homo sapiens_hsa041461.80852339
23Lysosome_Homo sapiens_hsa041421.74141177
24PPAR signaling pathway_Homo sapiens_hsa033201.73302783
25Sulfur relay system_Homo sapiens_hsa041221.71712626
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69731049
27Sulfur metabolism_Homo sapiens_hsa009201.55735566
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55271327
29Carbon metabolism_Homo sapiens_hsa012001.49426117
30RNA polymerase_Homo sapiens_hsa030201.40943039
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36305033
32Asthma_Homo sapiens_hsa053101.35311324
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.34771083
34Nitrogen metabolism_Homo sapiens_hsa009101.32664630
35Allograft rejection_Homo sapiens_hsa053301.29366299
36Complement and coagulation cascades_Homo sapiens_hsa046101.25674599
37Graft-versus-host disease_Homo sapiens_hsa053321.24930243
38Biosynthesis of amino acids_Homo sapiens_hsa012301.24656875
39Pyruvate metabolism_Homo sapiens_hsa006201.24508304
40Autoimmune thyroid disease_Homo sapiens_hsa053201.24378966
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23728754
42Hematopoietic cell lineage_Homo sapiens_hsa046401.22007351
43Arginine and proline metabolism_Homo sapiens_hsa003301.19653964
44Platelet activation_Homo sapiens_hsa046111.19625773
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17396793
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.16255617
47Cardiac muscle contraction_Homo sapiens_hsa042601.15620583
48Glutathione metabolism_Homo sapiens_hsa004801.14075148
49Linoleic acid metabolism_Homo sapiens_hsa005911.13120499
50Ether lipid metabolism_Homo sapiens_hsa005651.12858077
51Regulation of autophagy_Homo sapiens_hsa041401.10711728
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.09917244
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05148732
54Sphingolipid metabolism_Homo sapiens_hsa006001.05104348
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04591231
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.02351733
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00568133
58beta-Alanine metabolism_Homo sapiens_hsa004100.96841091
59Histidine metabolism_Homo sapiens_hsa003400.96065156
60Staphylococcus aureus infection_Homo sapiens_hsa051500.94469845
61Oxidative phosphorylation_Homo sapiens_hsa001900.92643982
62Type I diabetes mellitus_Homo sapiens_hsa049400.91715516
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90647569
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88094827
65Protein export_Homo sapiens_hsa030600.86583918
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85989868
67Ribosome_Homo sapiens_hsa030100.83720124
68Glycerolipid metabolism_Homo sapiens_hsa005610.83249774
69Metabolic pathways_Homo sapiens_hsa011000.82298116
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82250326
71Primary immunodeficiency_Homo sapiens_hsa053400.80574484
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79492079
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77346727
74Chemical carcinogenesis_Homo sapiens_hsa052040.75824543
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75373413
76Tryptophan metabolism_Homo sapiens_hsa003800.73771592
77Rheumatoid arthritis_Homo sapiens_hsa053230.73406746
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73093227
79Phagosome_Homo sapiens_hsa041450.72699175
80Homologous recombination_Homo sapiens_hsa034400.72596512
81Malaria_Homo sapiens_hsa051440.70911391
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69878347
83Legionellosis_Homo sapiens_hsa051340.67724235
84Other glycan degradation_Homo sapiens_hsa005110.67472028
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.67266619
86Arginine biosynthesis_Homo sapiens_hsa002200.65151659
87Antigen processing and presentation_Homo sapiens_hsa046120.63423106
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62763529
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60783203
90Basal transcription factors_Homo sapiens_hsa030220.60088612
91Mineral absorption_Homo sapiens_hsa049780.59996316
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59537601
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58885146
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58168996
95Synaptic vesicle cycle_Homo sapiens_hsa047210.57953176
96Caffeine metabolism_Homo sapiens_hsa002320.57939601
97Parkinsons disease_Homo sapiens_hsa050120.53706523
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50915146
99Phototransduction_Homo sapiens_hsa047440.50405193
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48433118
101Bile secretion_Homo sapiens_hsa049760.48189285
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.48107336
103ECM-receptor interaction_Homo sapiens_hsa045120.46587896
104Retinol metabolism_Homo sapiens_hsa008300.46279651
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.46237387
106Systemic lupus erythematosus_Homo sapiens_hsa053220.43432907
107Starch and sucrose metabolism_Homo sapiens_hsa005000.42637947
108Tuberculosis_Homo sapiens_hsa051520.41362119
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41219812
110Chemokine signaling pathway_Homo sapiens_hsa040620.40943801
111Collecting duct acid secretion_Homo sapiens_hsa049660.39983114
112Selenocompound metabolism_Homo sapiens_hsa004500.39091314
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38773179
114Shigellosis_Homo sapiens_hsa051310.38639985
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35598304
116Alzheimers disease_Homo sapiens_hsa050100.34932184
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34430636
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33932086
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33201174
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32467650
121Tyrosine metabolism_Homo sapiens_hsa003500.30909023
122Prion diseases_Homo sapiens_hsa050200.30826522
123Pyrimidine metabolism_Homo sapiens_hsa002400.30289677
124Renin-angiotensin system_Homo sapiens_hsa046140.29832585
125Arachidonic acid metabolism_Homo sapiens_hsa005900.29387361
126Fat digestion and absorption_Homo sapiens_hsa049750.27966261
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27799344
128Vibrio cholerae infection_Homo sapiens_hsa051100.27481179
129Purine metabolism_Homo sapiens_hsa002300.26937848
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26643233
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25906126
132Fructose and mannose metabolism_Homo sapiens_hsa000510.24555260
133N-Glycan biosynthesis_Homo sapiens_hsa005100.23126047
134Renal cell carcinoma_Homo sapiens_hsa052110.21686502
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21018731

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