EMB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gamma-delta T cell differentiation (GO:0045586)4.80725775
2COPI coating of Golgi vesicle (GO:0048205)4.76546735
3Golgi transport vesicle coating (GO:0048200)4.76546735
4negative T cell selection (GO:0043383)4.75499760
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.74040354
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.74040354
7regulation of gamma-delta T cell activation (GO:0046643)4.73791196
8negative thymic T cell selection (GO:0045060)4.67658859
9positive thymic T cell selection (GO:0045059)4.49448508
10detection of other organism (GO:0098543)4.40031256
11signal peptide processing (GO:0006465)4.39248475
12ribosomal small subunit assembly (GO:0000028)4.33189612
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.27658368
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.27658368
15modulation by symbiont of host immune response (GO:0052553)4.27658368
16positive regulation by symbiont of host defense response (GO:0052509)4.27658368
17modulation by symbiont of host defense response (GO:0052031)4.27658368
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.27658368
19positive T cell selection (GO:0043368)4.25196831
20detection of bacterium (GO:0016045)4.21678392
21B cell receptor signaling pathway (GO:0050853)4.06295354
22T cell selection (GO:0045058)3.98836108
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98572014
24antigen processing and presentation of endogenous antigen (GO:0019883)3.95909363
25negative regulation of T cell mediated immunity (GO:0002710)3.93492188
26positive regulation of granulocyte differentiation (GO:0030854)3.85341187
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83660542
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.77464293
29cotranslational protein targeting to membrane (GO:0006613)3.73408616
30protein targeting to ER (GO:0045047)3.72800918
31thymic T cell selection (GO:0045061)3.72261945
32macrophage activation involved in immune response (GO:0002281)3.70640781
33response to interleukin-15 (GO:0070672)3.64614539
34protein maturation by protein folding (GO:0022417)3.62776301
35regulation of tolerance induction (GO:0002643)3.55220162
36establishment of protein localization to endoplasmic reticulum (GO:0072599)3.54933211
37protein localization to endoplasmic reticulum (GO:0070972)3.50366591
38detection of external biotic stimulus (GO:0098581)3.49730438
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.48924642
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44320585
41cellular response to interleukin-15 (GO:0071350)3.42911334
42regulation of alpha-beta T cell proliferation (GO:0046640)3.40933200
43activated T cell proliferation (GO:0050798)3.40625180
44viral transcription (GO:0019083)3.38145526
45myeloid cell activation involved in immune response (GO:0002275)3.38128134
46regulation of interferon-beta biosynthetic process (GO:0045357)3.37590719
47negative regulation of phagocytosis (GO:0050765)3.37192867
48negative regulation of erythrocyte differentiation (GO:0045647)3.36033533
49negative regulation of interleukin-12 production (GO:0032695)3.35046630
50positive regulation of tolerance induction (GO:0002645)3.34121506
51DNA deamination (GO:0045006)3.32333056
52response to host immune response (GO:0052572)3.31100660
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31100660
54translational termination (GO:0006415)3.30397524
55respiratory burst (GO:0045730)3.29473446
56negative regulation of leukocyte mediated immunity (GO:0002704)3.29408978
57regulation of T cell tolerance induction (GO:0002664)3.28075927
58DNA strand elongation involved in DNA replication (GO:0006271)3.25569210
59telomere maintenance via semi-conservative replication (GO:0032201)3.23280542
60microglial cell activation (GO:0001774)3.20456993
61neutrophil activation involved in immune response (GO:0002283)3.20048118
62antigen processing and presentation via MHC class Ib (GO:0002475)3.15606130
63detection of biotic stimulus (GO:0009595)3.12073509
64antigen receptor-mediated signaling pathway (GO:0050851)3.11621429
65sequestering of metal ion (GO:0051238)3.11617799
66DNA strand elongation (GO:0022616)3.10085114
67positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08932708
68response to host (GO:0075136)3.08353087
69response to host defenses (GO:0052200)3.08353087
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08353087
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06753814
72folic acid-containing compound biosynthetic process (GO:0009396)3.06281563
73regulation of regulatory T cell differentiation (GO:0045589)3.02721268
74translational elongation (GO:0006414)3.02484359
75DNA unwinding involved in DNA replication (GO:0006268)3.01612526
76detection of molecule of bacterial origin (GO:0032490)2.97709470
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.97393871
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95200933
79regulation of protein heterodimerization activity (GO:0043497)2.94447866
80telomere maintenance via recombination (GO:0000722)2.94306283
81neutrophil mediated immunity (GO:0002446)2.92016417
82T cell receptor signaling pathway (GO:0050852)2.91978273
83regulation of granulocyte differentiation (GO:0030852)2.91294579
84interferon-gamma production (GO:0032609)2.91003262
85regulation of mast cell degranulation (GO:0043304)2.87745514
86IMP biosynthetic process (GO:0006188)2.87057356
87macrophage activation (GO:0042116)2.84927288
88interferon-gamma-mediated signaling pathway (GO:0060333)2.84895508
89regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84486253
90negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.83742434
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83451716
92positive regulation of interferon-alpha production (GO:0032727)2.81643010
93IMP metabolic process (GO:0046040)2.79889968
94negative regulation of adaptive immune response (GO:0002820)2.79646454
95dendritic cell migration (GO:0036336)2.79613425
96immunoglobulin mediated immune response (GO:0016064)2.79390364
97maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79311983
98dendritic cell chemotaxis (GO:0002407)2.78585200
99response to peptidoglycan (GO:0032494)2.77711276
100positive regulation of mast cell activation (GO:0033005)2.76480650
101T cell costimulation (GO:0031295)2.75401358
102viral life cycle (GO:0019058)2.74207974
103chaperone mediated protein folding requiring cofactor (GO:0051085)2.73065035
104hepatocyte apoptotic process (GO:0097284)2.72354486
105regulation of natural killer cell mediated immunity (GO:0002715)2.71984326
106regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.71984326
107lymphocyte costimulation (GO:0031294)2.71386993
108regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70459529
109negative regulation of T-helper cell differentiation (GO:0045623)2.69886535
110DNA replication initiation (GO:0006270)2.68274495
111mast cell activation (GO:0045576)2.66139187
112mitotic recombination (GO:0006312)2.64266371
113nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.64051658
114dosage compensation (GO:0007549)2.63273391
115ribosomal small subunit biogenesis (GO:0042274)2.62779805
116reactive oxygen species biosynthetic process (GO:1903409)2.61161995
117maturation of SSU-rRNA (GO:0030490)2.59386683
118translational initiation (GO:0006413)2.58802371
119leukocyte aggregation (GO:0070486)2.58457442
120B cell mediated immunity (GO:0019724)2.57351896
121positive regulation of gamma-delta T cell activation (GO:0046645)2.56831411
122negative regulation of glycoprotein biosynthetic process (GO:0010561)2.56772163
123formation of translation preinitiation complex (GO:0001731)2.56380740
124actin nucleation (GO:0045010)2.52721739
125cellular protein complex disassembly (GO:0043624)2.51185827
126nucleobase biosynthetic process (GO:0046112)2.49329725
127angiogenesis involved in wound healing (GO:0060055)2.48884897
128protein targeting to membrane (GO:0006612)2.45384324
129regulation of B cell differentiation (GO:0045577)2.45123049
130antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.45031265
131positive regulation of B cell differentiation (GO:0045579)2.44009930
132leukocyte degranulation (GO:0043299)2.43900244
133cellular response to zinc ion (GO:0071294)2.43681752
134deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.43198028
135intra-S DNA damage checkpoint (GO:0031573)2.41937421
136regulation of B cell receptor signaling pathway (GO:0050855)2.39745586
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39108616
138protein retention in ER lumen (GO:0006621)2.38889984
139neutrophil activation (GO:0042119)2.38264225
140production of molecular mediator involved in inflammatory response (GO:0002532)2.38026951
141tolerance induction (GO:0002507)2.36593008
142response to protozoan (GO:0001562)2.36002406
143telomere maintenance via telomere lengthening (GO:0010833)2.35178191
144defense response to protozoan (GO:0042832)2.34499067
145positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.33520279
146DNA replication checkpoint (GO:0000076)2.33420285
147response to fungus (GO:0009620)2.33074526
148negative regulation of growth of symbiont in host (GO:0044130)2.32699592
149negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.32699592
150modulation of growth of symbiont involved in interaction with host (GO:0044144)2.32699592
151regulation of growth of symbiont in host (GO:0044126)2.32699592
152negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.32320005
153negative regulation of cell killing (GO:0031342)2.32320005
154response to interferon-beta (GO:0035456)2.31838000
155myeloid leukocyte mediated immunity (GO:0002444)2.31808988
156T cell apoptotic process (GO:0070231)2.28056833
157protein complex disassembly (GO:0043241)2.25801575
158regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.25638324
159positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.24818326
160granulocyte activation (GO:0036230)2.24068042
161nucleobase-containing small molecule interconversion (GO:0015949)2.22453886
162cellular response to interferon-beta (GO:0035458)2.22409527
163pteridine-containing compound biosynthetic process (GO:0042559)2.22381574
164nuclear-transcribed mRNA catabolic process (GO:0000956)2.20850759
165cellular extravasation (GO:0045123)2.20366666
166response to muramyl dipeptide (GO:0032495)2.20204065
167T cell migration (GO:0072678)2.20148248
168ribosomal large subunit biogenesis (GO:0042273)2.18943315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.54603157
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.46445523
3RUNX_20019798_ChIP-Seq_JUKART_Human3.18807194
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11673045
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.84279723
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.78106759
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61857589
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57853630
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.55514832
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49100144
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46078103
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37440473
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.32482435
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.29607421
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29441211
16MYC_22102868_ChIP-Seq_BL_Human2.28679975
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21360982
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16554943
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.16008175
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14838329
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.08482885
22VDR_21846776_ChIP-Seq_THP-1_Human2.07041753
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05857441
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.05687670
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04865718
26SPI1_23127762_ChIP-Seq_K562_Human2.03296712
27SPI1_23547873_ChIP-Seq_NB4_Human2.02886007
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02461628
29VDR_23849224_ChIP-Seq_CD4+_Human2.00727085
30SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.00275501
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94461510
32* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93714544
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91688434
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90461263
35* MYB_26560356_Chip-Seq_TH2_Human1.88418480
36* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88209753
37* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85628796
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85069512
39VDR_24787735_ChIP-Seq_THP-1_Human1.84984489
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84942167
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84710023
42* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.83858442
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83388653
44* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83253855
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79977599
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78700268
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75080965
48MAF_26560356_Chip-Seq_TH2_Human1.72025177
49FOXP3_21729870_ChIP-Seq_TREG_Human1.70877524
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.70702145
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70680233
52XRN2_22483619_ChIP-Seq_HELA_Human1.67768876
53SCL_19346495_ChIP-Seq_HPC-7_Human1.67435721
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65740052
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64915255
56* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63549738
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62138195
58TFEB_21752829_ChIP-Seq_HELA_Human1.61377484
59GATA1_22025678_ChIP-Seq_K562_Human1.60946955
60* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60619676
61ELK1_19687146_ChIP-ChIP_HELA_Human1.60549805
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59421626
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.57386674
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.57211173
65MYB_26560356_Chip-Seq_TH1_Human1.55884068
66* IRF8_27001747_Chip-Seq_BMDM_Mouse1.54830328
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.53469473
68* VDR_24763502_ChIP-Seq_THP-1_Human1.51981383
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51298118
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51005837
71MAF_26560356_Chip-Seq_TH1_Human1.50954089
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49466285
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48341250
74CIITA_25753668_ChIP-Seq_RAJI_Human1.47103681
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.46284901
76DCP1A_22483619_ChIP-Seq_HELA_Human1.46036286
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45870175
78* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44828686
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41365775
80UTX_26944678_Chip-Seq_JUKART_Human1.40265691
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39917150
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38900778
83GABP_19822575_ChIP-Seq_HepG2_Human1.38676099
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37897390
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.37611613
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36143851
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33539554
88TTF2_22483619_ChIP-Seq_HELA_Human1.33525043
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31161853
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28843339
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26755259
92KDM2B_26808549_Chip-Seq_DND41_Human1.25009465
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24579571
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.22593752
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22462865
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21227995
97* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18879925
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17818764
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15769772
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13751595
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13540470
102GATA3_27048872_Chip-Seq_THYMUS_Human1.12530481
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12047595
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09752172
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09251717
106* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08888515
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08561633
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08052447
109TCF7_22412390_ChIP-Seq_EML_Mouse1.07266281
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06798499
111GATA1_19941826_ChIP-Seq_K562_Human1.06719047
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.06081002
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05851338
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05650702
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05366337
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04378562
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03237993
118PU_27001747_Chip-Seq_BMDM_Mouse1.02068513
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01545284
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01329985
121KDM5A_27292631_Chip-Seq_BREAST_Human1.01089207
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97225623
123GATA2_19941826_ChIP-Seq_K562_Human0.96227760
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95868884
125GATA3_26560356_Chip-Seq_TH2_Human0.94996210
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93437949
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92441533
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92164663
129PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92020976
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91518397
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.91143382
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87593122
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87162902
134RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85545603
135VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85155912
136NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83958222
137NCOR1_26117541_ChIP-Seq_K562_Human0.80462385
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79725167
139ELK3_25401928_ChIP-Seq_HUVEC_Human0.79010636
140ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75958540
141GATA2_21666600_ChIP-Seq_HMVEC_Human0.74235056
142SMRT_27268052_Chip-Seq_Bcells_Human0.71200240
143GATA1_19941827_ChIP-Seq_MEL86_Mouse0.67591359
144GATA3_26560356_Chip-Seq_TH1_Human0.67409562

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.24899177
2MP0003436_decreased_susceptibility_to2.98663070
3MP0003693_abnormal_embryo_hatching2.80204908
4MP0009785_altered_susceptibility_to2.77505899
5MP0002877_abnormal_melanocyte_morpholog2.72423976
6MP0002396_abnormal_hematopoietic_system2.69098203
7MP0005671_abnormal_response_to2.51058005
8MP0005000_abnormal_immune_tolerance2.45102227
9MP0003763_abnormal_thymus_physiology2.35518571
10MP0002009_preneoplasia2.28901787
11MP0003183_abnormal_peptide_metabolism2.28634712
12MP0002419_abnormal_innate_immunity2.23641965
13MP0005025_abnormal_response_to2.22640096
14MP0002148_abnormal_hypersensitivity_rea2.19632469
15MP0003303_peritoneal_inflammation2.19534811
16MP0000685_abnormal_immune_system2.14233828
17MP0003300_gastrointestinal_ulcer2.09388112
18MP0002420_abnormal_adaptive_immunity2.08270975
19MP0009333_abnormal_splenocyte_physiolog2.06563706
20MP0001819_abnormal_immune_cell2.06317089
21MP0002723_abnormal_immune_serum2.06077376
22MP0002452_abnormal_antigen_presenting2.02480297
23MP0001800_abnormal_humoral_immune2.01090213
24MP0003724_increased_susceptibility_to2.00671750
25MP0002405_respiratory_system_inflammati1.92075550
26MP0010094_abnormal_chromosome_stability1.92023046
27MP0002166_altered_tumor_susceptibility1.90313646
28MP0002398_abnormal_bone_marrow1.88889371
29MP0004808_abnormal_hematopoietic_stem1.85302497
30MP0008007_abnormal_cellular_replicative1.84425227
31MP0005387_immune_system_phenotype1.82743945
32MP0001790_abnormal_immune_system1.82743945
33MP0004957_abnormal_blastocyst_morpholog1.80920802
34MP0003172_abnormal_lysosome_physiology1.76882311
35MP0010352_gastrointestinal_tract_polyps1.75977211
36MP0000716_abnormal_immune_system1.74455218
37MP0010307_abnormal_tumor_latency1.73099648
38MP0010155_abnormal_intestine_physiology1.72475566
39MP0000490_abnormal_crypts_of1.71659933
40MP0000858_altered_metastatic_potential1.71156902
41MP0005464_abnormal_platelet_physiology1.71089579
42MP0002693_abnormal_pancreas_physiology1.70270922
43MP0003866_abnormal_defecation1.67408366
44MP0004381_abnormal_hair_follicle1.66671452
45MP0002006_tumorigenesis1.65071206
46MP0003077_abnormal_cell_cycle1.60963514
47MP0002722_abnormal_immune_system1.58930028
48MP0001853_heart_inflammation1.58852842
49MP0001845_abnormal_inflammatory_respons1.57518904
50MP0000703_abnormal_thymus_morphology1.53232878
51MP0003191_abnormal_cellular_cholesterol1.52481934
52MP0002429_abnormal_blood_cell1.52285365
53MP0005058_abnormal_lysosome_morphology1.51538932
54MP0000689_abnormal_spleen_morphology1.51049619
55MP0001545_abnormal_hematopoietic_system1.48674324
56MP0005397_hematopoietic_system_phenotyp1.48674324
57MP0003828_pulmonary_edema1.48627797
58MP0005174_abnormal_tail_pigmentation1.48168390
59MP0004947_skin_inflammation1.47292856
60MP0001533_abnormal_skeleton_physiology1.42412099
61MP0008057_abnormal_DNA_replication1.39546091
62MP0008260_abnormal_autophagy1.38348410
63MP0008058_abnormal_DNA_repair1.37938090
64MP0000465_gastrointestinal_hemorrhage1.37605745
65MP0005451_abnormal_body_composition1.30045510
66MP0004264_abnormal_extraembryonic_tissu1.28200522
67MP0000569_abnormal_digit_pigmentation1.24983386
68MP0001986_abnormal_taste_sensitivity1.24165811
69MP0003111_abnormal_nucleus_morphology1.23978699
70MP0000678_abnormal_parathyroid_gland1.23928202
71MP0006054_spinal_hemorrhage1.23519887
72MP0003656_abnormal_erythrocyte_physiolo1.21332830
73MP0002019_abnormal_tumor_incidence1.20531785
74MP0002933_joint_inflammation1.19485992
75MP0003448_altered_tumor_morphology1.16327259
76MP0004782_abnormal_surfactant_physiolog1.15813070
77MP0002132_abnormal_respiratory_system1.15291194
78MP0001873_stomach_inflammation1.13889120
79MP0001944_abnormal_pancreas_morphology1.13785644
80MP0000343_altered_response_to1.12900201
81MP0009278_abnormal_bone_marrow1.11974119
82MP0009764_decreased_sensitivity_to1.09453182
83MP0008469_abnormal_protein_level1.09424118
84MP0005310_abnormal_salivary_gland1.08749738
85MP0005076_abnormal_cell_differentiation1.00503859
86MP0000350_abnormal_cell_proliferation0.99850781
87MP0004883_abnormal_blood_vessel0.98695730
88MP0005075_abnormal_melanosome_morpholog0.98318853
89MP0005166_decreased_susceptibility_to0.93721649
90MP0006082_CNS_inflammation0.92364634
91MP0000313_abnormal_cell_death0.91166489
92MP0003186_abnormal_redox_activity0.89131813
93MP0005220_abnormal_exocrine_pancreas0.88163395
94MP0009763_increased_sensitivity_to0.87189311
95MP0003795_abnormal_bone_structure0.85564253
96MP0003075_altered_response_to0.85555579
97MP0001851_eye_inflammation0.85148041
98MP0000371_diluted_coat_color0.84542989
99MP0005360_urolithiasis0.81612267
100MP0002095_abnormal_skin_pigmentation0.81337161
101MP0008932_abnormal_embryonic_tissue0.78401812
102MP0002928_abnormal_bile_duct0.75163623
103MP0005164_abnormal_response_to0.73503308
104MP0003045_fibrosis0.73471839
105MP0003123_paternal_imprinting0.73281825
106MP0003786_premature_aging0.72289705
107MP0000372_irregular_coat_pigmentation0.72096608
108MP0005390_skeleton_phenotype0.72050907
109MP0004185_abnormal_adipocyte_glucose0.72047967
110MP0000681_abnormal_thyroid_gland0.71771011
111MP0001730_embryonic_growth_arrest0.70635308
112MP0000015_abnormal_ear_pigmentation0.70020724
113MP0005023_abnormal_wound_healing0.69293068
114MP0003566_abnormal_cell_adhesion0.69138720
115MP0001663_abnormal_digestive_system0.68631942
116MP0008004_abnormal_stomach_pH0.68322988
117MP0009765_abnormal_xenobiotic_induced0.67419822
118MP0002998_abnormal_bone_remodeling0.66398805
119MP0010386_abnormal_urinary_bladder0.65649522
120MP0002277_abnormal_respiratory_mucosa0.64017484
121MP0000249_abnormal_blood_vessel0.63684273
122MP0003890_abnormal_embryonic-extraembry0.61385070
123MP0001765_abnormal_ion_homeostasis0.58700962
124MP0002796_impaired_skin_barrier0.56453753
125MP0000604_amyloidosis0.56440895
126MP0003221_abnormal_cardiomyocyte_apopto0.55760620
127MP0005409_darkened_coat_color0.55513666
128MP0010234_abnormal_vibrissa_follicle0.55300465
129MP0003806_abnormal_nucleotide_metabolis0.54733192
130MP0003453_abnormal_keratinocyte_physiol0.53678380
131MP0003252_abnormal_bile_duct0.53587981
132MP0003091_abnormal_cell_migration0.52503531
133MP0002138_abnormal_hepatobiliary_system0.51280322

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.01575145
2Eczematoid dermatitis (HP:0000976)4.58993477
3Elevated erythrocyte sedimentation rate (HP:0003565)4.58304624
4Recurrent abscess formation (HP:0002722)4.23486717
5Thrombocytosis (HP:0001894)4.19602011
6IgM deficiency (HP:0002850)4.07261848
7Orchitis (HP:0100796)3.69329681
8Recurrent bacterial skin infections (HP:0005406)3.67793066
9Encephalitis (HP:0002383)3.47155858
10Optic neuritis (HP:0100653)3.46459409
11Retrobulbar optic neuritis (HP:0100654)3.46459409
12Gastrointestinal infarctions (HP:0005244)3.44742915
13Panhypogammaglobulinemia (HP:0003139)3.42353363
14Papilledema (HP:0001085)3.40503670
15Pustule (HP:0200039)3.34663536
16Abnormality of T cell physiology (HP:0011840)3.28538642
17Autoimmune hemolytic anemia (HP:0001890)3.26240296
18Abnormality of T cells (HP:0002843)3.13831431
19Interstitial pulmonary disease (HP:0006530)3.07447674
20Inflammation of the large intestine (HP:0002037)3.06937230
21Aplastic anemia (HP:0001915)3.05213886
22Chronic otitis media (HP:0000389)3.04941481
23Increased IgE level (HP:0003212)2.98345609
24Agammaglobulinemia (HP:0004432)2.98121873
25Urticaria (HP:0001025)2.96696187
26Gastrointestinal inflammation (HP:0004386)2.95531836
27Chronic obstructive pulmonary disease (HP:0006510)2.95506603
28Obstructive lung disease (HP:0006536)2.95506603
29Vacuolated lymphocytes (HP:0001922)2.94328947
30T lymphocytopenia (HP:0005403)2.94112588
31Severe combined immunodeficiency (HP:0004430)2.88414949
32Prolonged bleeding time (HP:0003010)2.84361360
33Recurrent bronchitis (HP:0002837)2.81270622
34Type I transferrin isoform profile (HP:0003642)2.79280477
35Chronic diarrhea (HP:0002028)2.76960848
36Colitis (HP:0002583)2.76820587
37Cellulitis (HP:0100658)2.75450612
38Abnormality of T cell number (HP:0011839)2.74469980
39Mediastinal lymphadenopathy (HP:0100721)2.74187147
40Recurrent fungal infections (HP:0002841)2.74116602
41Abnormality of macrophages (HP:0004311)2.73558923
42Epistaxis (HP:0000421)2.69340848
43Meningitis (HP:0001287)2.64304014
44Reticulocytopenia (HP:0001896)2.60544325
45Dysostosis multiplex (HP:0000943)2.59494875
46Urinary glycosaminoglycan excretion (HP:0003541)2.58286740
47Mucopolysacchariduria (HP:0008155)2.58286740
48Abnormality of the prostate (HP:0008775)2.55808699
49Abnormal glycosylation (HP:0012345)2.52625653
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52625653
51Abnormal protein N-linked glycosylation (HP:0012347)2.52625653
52Abnormal protein glycosylation (HP:0012346)2.52625653
5311 pairs of ribs (HP:0000878)2.51100263
54Gingival bleeding (HP:0000225)2.50720343
55Abnormality of eosinophils (HP:0001879)2.48677852
56Pulmonary infiltrates (HP:0002113)2.46266058
57Thoracolumbar scoliosis (HP:0002944)2.46208772
58Hemoptysis (HP:0002105)2.44325992
59Agnosia (HP:0010524)2.44038779
60Recurrent gram-negative bacterial infections (HP:0005420)2.43388158
61Recurrent viral infections (HP:0004429)2.42918577
62Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42447279
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42267820
64Keratoconjunctivitis sicca (HP:0001097)2.41414088
65Pulmonary embolism (HP:0002204)2.40474051
66Abnormality of the anterior horn cell (HP:0006802)2.40345555
67Degeneration of anterior horn cells (HP:0002398)2.40345555
68Amyloidosis (HP:0011034)2.39956818
69B lymphocytopenia (HP:0010976)2.39658001
70Abnormality of B cell number (HP:0010975)2.39658001
71Spontaneous hematomas (HP:0007420)2.39172939
72Increased IgM level (HP:0003496)2.38172351
73Abnormal delayed hypersensitivity skin test (HP:0002963)2.37575270
74Combined immunodeficiency (HP:0005387)2.36588058
75Vasculitis (HP:0002633)2.36090418
76Abnormality of cells of the erythroid lineage (HP:0012130)2.35972156
77Gangrene (HP:0100758)2.35562506
78Autoimmune thrombocytopenia (HP:0001973)2.34202551
79Papilloma (HP:0012740)2.31381073
80Verrucae (HP:0200043)2.31381073
81Hypochromic microcytic anemia (HP:0004840)2.29894020
82Acute myeloid leukemia (HP:0004808)2.29632551
83Abnormality of polysaccharide metabolism (HP:0011012)2.28834373
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28834373
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28834373
86Petechiae (HP:0000967)2.26695602
87Skin ulcer (HP:0200042)2.26422793
88Recurrent skin infections (HP:0001581)2.24654434
89Abnormal number of erythroid precursors (HP:0012131)2.24535519
90Bronchitis (HP:0012387)2.23708025
91Viral hepatitis (HP:0006562)2.21553041
92Hypochromic anemia (HP:0001931)2.21406305
93Skin rash (HP:0000988)2.20488712
94Lymphoma (HP:0002665)2.19491710
95Anorexia (HP:0002039)2.19045731
96Sepsis (HP:0100806)2.18400625
97Reduced antithrombin III activity (HP:0001976)2.17143934
98Keratoconjunctivitis (HP:0001096)2.15151442
99Poor head control (HP:0002421)2.13594169
100Lymphopenia (HP:0001888)2.13404263
101Abnormality of cells of the lymphoid lineage (HP:0012140)2.13209707
102Arterial thrombosis (HP:0004420)2.12408660
103Abnormality of the pleura (HP:0002103)2.11661391
104Chest pain (HP:0100749)2.10856095
105Pulmonary fibrosis (HP:0002206)2.08903095
106Hypoplasia of the thymus (HP:0000778)2.08446711
107Hypoglycemic seizures (HP:0002173)2.07710153
108Symptomatic seizures (HP:0011145)2.07306550
109IgG deficiency (HP:0004315)2.03859023
110Increased cerebral lipofuscin (HP:0011813)2.02512665
111Increased density of long bones (HP:0006392)2.00413892
112Osteomyelitis (HP:0002754)2.00347386
113Microcytic anemia (HP:0001935)1.99445517
114Acute hepatic failure (HP:0006554)1.99305513
115Glomerulopathy (HP:0100820)1.98760199
116IgA deficiency (HP:0002720)1.98042233
117Stomatitis (HP:0010280)1.97989880
118Abnormality of glycolipid metabolism (HP:0010969)1.97025532
119Abnormality of liposaccharide metabolism (HP:0010968)1.97025532
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.97025532
121Amaurosis fugax (HP:0100576)1.97007743
122Gingivitis (HP:0000230)1.96861928
123Fatigue (HP:0012378)1.96662217
124Nasal polyposis (HP:0100582)1.96497887
125Colon cancer (HP:0003003)1.96360936
126Basal ganglia calcification (HP:0002135)1.95306394
127Slow saccadic eye movements (HP:0000514)1.94894420
128Broad face (HP:0000283)1.92850855
129Generalized aminoaciduria (HP:0002909)1.92534635
130Abnormality of the fingertips (HP:0001211)1.90714449
131Thyroiditis (HP:0100646)1.90517720
132Hypergammaglobulinemia (HP:0010702)1.90062529
133Progressive neurologic deterioration (HP:0002344)1.89723711
134Leukocytosis (HP:0001974)1.89602708
135Acute lymphatic leukemia (HP:0006721)1.89493611
136Chronic mucocutaneous candidiasis (HP:0002728)1.89352773
137Recurrent cutaneous fungal infections (HP:0011370)1.89352773
138Joint swelling (HP:0001386)1.89045437
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.88476353
140Granulocytopenia (HP:0001913)1.88067226
141Premature loss of primary teeth (HP:0006323)1.86767177
142Periodontitis (HP:0000704)1.86596895
143Eosinophilia (HP:0001880)1.86325704
144Myelodysplasia (HP:0002863)1.85044692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT33.62252457
2PASK3.27501064
3TXK2.91121610
4TAOK32.75952297
5MAP4K12.58884496
6PRPF4B2.54937965
7IRAK42.54401577
8SCYL22.32082997
9CSK2.23612341
10IRAK32.21079996
11EIF2AK32.18490851
12KIT2.13594567
13ZAP701.98583993
14MAP2K31.88069738
15BLK1.86588065
16PIM21.80430947
17NME21.69486980
18MAP3K131.68698552
19STK161.66069015
20JAK31.65181773
21WEE11.64075958
22CDC71.62301868
23ERN11.56808214
24TNK21.55688795
25BRSK21.54218130
26RPS6KA41.52522940
27* BTK1.52216882
28* TEC1.51840749
29STK101.50050846
30TBK11.48021722
31BMPR21.46754673
32EEF2K1.45200319
33BUB11.45052114
34HIPK21.43250122
35LRRK21.35505158
36EIF2AK11.31776660
37TSSK61.29705230
38VRK11.28275902
39TYK21.26391854
40PIM11.23432687
41ACVR1B1.22156618
42MAP3K141.22097735
43TGFBR11.21509111
44PKN21.20691808
45TESK11.20346625
46SIK31.17307575
47TESK21.14296000
48NLK1.12580351
49CSF1R1.08716105
50RPS6KB21.07290892
51IKBKE1.00883528
52NEK21.00085516
53MAPKAPK30.99735889
54MAP3K20.99658923
55FGR0.98354671
56MAPK150.97418376
57LCK0.96010891
58CDK190.95773165
59MAP3K30.94910977
60MAP3K60.94863641
61JAK10.94563646
62MARK30.93143629
63IKBKB0.91799844
64PAK40.91332151
65PRKCQ0.90602212
66NEK90.88771868
67GRK60.87157451
68FES0.86509478
69* SYK0.86101838
70ATR0.85673028
71PDK10.84622803
72MAP3K110.83203371
73* ITK0.81303974
74MAP3K120.81124298
75MST40.78051210
76EPHB10.77743806
77TAOK10.76446803
78CAMKK20.72991332
79KSR20.72461491
80INSRR0.70453205
81TRIB30.69996532
82MAP3K80.69846640
83JAK20.69624267
84HCK0.69329807
85CLK10.68979834
86CDK70.68671634
87MAPK70.68597013
88FRK0.68475069
89SRPK10.68091314
90SMG10.65008187
91MAPK120.63936782
92PIK3CG0.63753080
93* LYN0.63542845
94RIPK40.63193018
95CDK120.63165718
96DYRK30.62326953
97CDK60.61438992
98FYN0.60677588
99MAP3K100.59706065
100PLK40.59369787
101AURKB0.59012868
102CAMKK10.58775054
103MAP2K20.58634424
104MAP2K60.58494807
105MATK0.57096799
106MAPK110.55435858
107TGFBR20.54561492
108TRPM70.54049574
109MAP3K10.52101179
110CHUK0.51922505
111MARK20.51440342
112FGFR30.50358375
113IRAK20.50139951
114BRSK10.49839142
115RPS6KA60.49811548
116RAF10.48607368
117PDPK10.48595800
118EPHA30.48023703
119ALK0.47959723
120TLK10.47863777
121STK40.47518883
122IRAK10.47395398
123CDK40.46312313
124GRK70.46071975
125BRD40.45991985
126PTK60.45669819
127CDK80.45597184
128MKNK10.45539940
129RPS6KL10.44798661
130RPS6KC10.44798661
131RET0.43709451
132KDR0.43237764
133MAP3K50.41144025
134YES10.40553641
135PLK10.40454114
136MAPKAPK20.39022777
137STK240.38467834
138MAP3K70.36511919
139SGK30.36122693
140FGFR40.35024847
141NEK60.34267771
142EGFR0.33882574
143DYRK1B0.30344141
144MELK0.29861895

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.37137019
2Protein export_Homo sapiens_hsa030603.20197627
3Mismatch repair_Homo sapiens_hsa034302.59129392
4Ribosome_Homo sapiens_hsa030102.53925025
5Staphylococcus aureus infection_Homo sapiens_hsa051502.24344114
6Antigen processing and presentation_Homo sapiens_hsa046122.12967303
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.07223555
8Leishmaniasis_Homo sapiens_hsa051401.99912884
9Legionellosis_Homo sapiens_hsa051341.95409571
10Base excision repair_Homo sapiens_hsa034101.95333314
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93445924
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77689100
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74403435
14Homologous recombination_Homo sapiens_hsa034401.70945848
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70009285
16Spliceosome_Homo sapiens_hsa030401.68368131
17Proteasome_Homo sapiens_hsa030501.62548375
18Other glycan degradation_Homo sapiens_hsa005111.60142705
19Primary immunodeficiency_Homo sapiens_hsa053401.57863811
20N-Glycan biosynthesis_Homo sapiens_hsa005101.50307389
21Measles_Homo sapiens_hsa051621.48610879
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.47808813
23Nucleotide excision repair_Homo sapiens_hsa034201.43414170
24Non-small cell lung cancer_Homo sapiens_hsa052231.42380496
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41833617
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.39362358
27Herpes simplex infection_Homo sapiens_hsa051681.37850783
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36829583
29One carbon pool by folate_Homo sapiens_hsa006701.36454939
30Non-homologous end-joining_Homo sapiens_hsa034501.35159092
31Osteoclast differentiation_Homo sapiens_hsa043801.33639365
32Pyrimidine metabolism_Homo sapiens_hsa002401.31912988
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30771580
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.29710639
35Hematopoietic cell lineage_Homo sapiens_hsa046401.25326021
36Asthma_Homo sapiens_hsa053101.24835587
37Type I diabetes mellitus_Homo sapiens_hsa049401.24567861
38Cell cycle_Homo sapiens_hsa041101.24475704
39Lysosome_Homo sapiens_hsa041421.24098165
40RNA transport_Homo sapiens_hsa030131.20828973
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20712721
42Allograft rejection_Homo sapiens_hsa053301.14512568
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13038219
44RNA polymerase_Homo sapiens_hsa030201.12770422
45RNA degradation_Homo sapiens_hsa030181.11301745
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09952336
47Pertussis_Homo sapiens_hsa051331.07878006
48Thyroid cancer_Homo sapiens_hsa052161.07745825
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.06853968
50Epstein-Barr virus infection_Homo sapiens_hsa051691.02174848
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01612695
52Apoptosis_Homo sapiens_hsa042101.00455481
53Acute myeloid leukemia_Homo sapiens_hsa052210.99794374
54Shigellosis_Homo sapiens_hsa051310.99660606
55Tuberculosis_Homo sapiens_hsa051520.99186589
56Influenza A_Homo sapiens_hsa051640.98214935
57p53 signaling pathway_Homo sapiens_hsa041150.97743774
58Toxoplasmosis_Homo sapiens_hsa051450.95073571
59T cell receptor signaling pathway_Homo sapiens_hsa046600.92570548
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91935965
61VEGF signaling pathway_Homo sapiens_hsa043700.88700800
62Hepatitis B_Homo sapiens_hsa051610.88507517
63TNF signaling pathway_Homo sapiens_hsa046680.86958962
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84960247
65Viral carcinogenesis_Homo sapiens_hsa052030.84359688
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82722833
67B cell receptor signaling pathway_Homo sapiens_hsa046620.82417639
68African trypanosomiasis_Homo sapiens_hsa051430.82074100
69Fanconi anemia pathway_Homo sapiens_hsa034600.81787614
70Phagosome_Homo sapiens_hsa041450.81193397
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80577550
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79742394
73Renin-angiotensin system_Homo sapiens_hsa046140.76597270
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75628228
75Renal cell carcinoma_Homo sapiens_hsa052110.75614021
76Galactose metabolism_Homo sapiens_hsa000520.73967977
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73577925
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72557172
79Salmonella infection_Homo sapiens_hsa051320.71839359
80Graft-versus-host disease_Homo sapiens_hsa053320.69348063
81FoxO signaling pathway_Homo sapiens_hsa040680.68999584
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68607234
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.68524689
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.67614478
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.66170730
86Systemic lupus erythematosus_Homo sapiens_hsa053220.65995494
87HTLV-I infection_Homo sapiens_hsa051660.64697867
88Pentose phosphate pathway_Homo sapiens_hsa000300.64521777
89Malaria_Homo sapiens_hsa051440.62821294
90Chronic myeloid leukemia_Homo sapiens_hsa052200.62088306
91Colorectal cancer_Homo sapiens_hsa052100.60799778
92Inositol phosphate metabolism_Homo sapiens_hsa005620.60562569
93Vibrio cholerae infection_Homo sapiens_hsa051100.59560181
94Rheumatoid arthritis_Homo sapiens_hsa053230.59462857
95Autoimmune thyroid disease_Homo sapiens_hsa053200.58861050
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58084152
97Selenocompound metabolism_Homo sapiens_hsa004500.58008458
98Chemokine signaling pathway_Homo sapiens_hsa040620.57919594
99Basal transcription factors_Homo sapiens_hsa030220.57324160
100Prolactin signaling pathway_Homo sapiens_hsa049170.57170103
101Dorso-ventral axis formation_Homo sapiens_hsa043200.57103167
102Choline metabolism in cancer_Homo sapiens_hsa052310.56182360
103Endometrial cancer_Homo sapiens_hsa052130.55728112
104Purine metabolism_Homo sapiens_hsa002300.54688331
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.52991552
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52791887
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.52389280
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50579800
109Insulin resistance_Homo sapiens_hsa049310.50333676
110GnRH signaling pathway_Homo sapiens_hsa049120.49566156
111Prostate cancer_Homo sapiens_hsa052150.49552250
112Amoebiasis_Homo sapiens_hsa051460.49430900
113mTOR signaling pathway_Homo sapiens_hsa041500.48552115
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47166566
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.44655605
116Endocytosis_Homo sapiens_hsa041440.44364834
117mRNA surveillance pathway_Homo sapiens_hsa030150.42104715
118Platelet activation_Homo sapiens_hsa046110.41865648
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41711423
120Folate biosynthesis_Homo sapiens_hsa007900.40372368
121Hepatitis C_Homo sapiens_hsa051600.40066933
122Regulation of autophagy_Homo sapiens_hsa041400.39567555
123Pancreatic cancer_Homo sapiens_hsa052120.39014229
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.38668776
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38286261
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37681863
127Viral myocarditis_Homo sapiens_hsa054160.36441534
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35627576
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34788499
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33228214
131ErbB signaling pathway_Homo sapiens_hsa040120.33025857
132Glioma_Homo sapiens_hsa052140.30685699
133Notch signaling pathway_Homo sapiens_hsa043300.30197002
134Small cell lung cancer_Homo sapiens_hsa052220.29207932

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