ELP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.46621366
2DNA strand elongation involved in DNA replication (GO:0006271)4.68119326
3DNA strand elongation (GO:0022616)4.49248841
4DNA replication initiation (GO:0006270)4.32306621
5protein localization to kinetochore (GO:0034501)4.30489041
6nucleobase biosynthetic process (GO:0046112)4.16724392
7IMP biosynthetic process (GO:0006188)4.15433160
8telomere maintenance via semi-conservative replication (GO:0032201)4.00377907
9peptidyl-arginine omega-N-methylation (GO:0035247)3.99139222
10regulation of centriole replication (GO:0046599)3.87640670
11DNA replication-dependent nucleosome assembly (GO:0006335)3.86994000
12DNA replication-dependent nucleosome organization (GO:0034723)3.86994000
13DNA double-strand break processing (GO:0000729)3.79196149
14cullin deneddylation (GO:0010388)3.77746855
15histone H2A acetylation (GO:0043968)3.74155395
16mitotic nuclear envelope disassembly (GO:0007077)3.66853126
17IMP metabolic process (GO:0046040)3.65918169
18purine nucleobase biosynthetic process (GO:0009113)3.65238720
19mitotic sister chromatid segregation (GO:0000070)3.63917094
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.61996524
21formation of translation preinitiation complex (GO:0001731)3.59094729
22protein deneddylation (GO:0000338)3.55952525
23establishment of integrated proviral latency (GO:0075713)3.55073697
24histone arginine methylation (GO:0034969)3.52244525
25maturation of SSU-rRNA (GO:0030490)3.52018801
26sister chromatid segregation (GO:0000819)3.49734511
27peptidyl-arginine methylation (GO:0018216)3.49567209
28peptidyl-arginine N-methylation (GO:0035246)3.49567209
29nuclear envelope disassembly (GO:0051081)3.46372461
30membrane disassembly (GO:0030397)3.46372461
31somatic hypermutation of immunoglobulin genes (GO:0016446)3.45063798
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.45063798
33folic acid-containing compound biosynthetic process (GO:0009396)3.44087837
34telomere maintenance via recombination (GO:0000722)3.39687661
35nuclear pore organization (GO:0006999)3.39083031
36ribosomal small subunit assembly (GO:0000028)3.39006671
37limb bud formation (GO:0060174)3.37304407
38mitotic recombination (GO:0006312)3.37201886
39protein localization to chromosome, centromeric region (GO:0071459)3.34390296
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.31813931
41attachment of spindle microtubules to kinetochore (GO:0008608)3.31668653
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.31217224
43mitotic metaphase plate congression (GO:0007080)3.30946949
44telomere maintenance via telomere lengthening (GO:0010833)3.28866037
45negative regulation of RNA splicing (GO:0033119)3.24569734
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21687696
47negative regulation of sister chromatid segregation (GO:0033046)3.21687696
48negative regulation of mitotic sister chromatid separation (GO:2000816)3.21687696
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21687696
50mitotic spindle assembly checkpoint (GO:0007094)3.20979166
51negative regulation of chromosome segregation (GO:0051985)3.20807712
52DNA geometric change (GO:0032392)3.19956870
53spindle assembly checkpoint (GO:0071173)3.19394745
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18358279
55CENP-A containing nucleosome assembly (GO:0034080)3.17434284
56DNA duplex unwinding (GO:0032508)3.17390883
57DNA replication checkpoint (GO:0000076)3.15424091
58chromatin remodeling at centromere (GO:0031055)3.13823843
59mitotic chromosome condensation (GO:0007076)3.13810429
60negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13009364
61spliceosomal snRNP assembly (GO:0000387)3.11724617
62non-recombinational repair (GO:0000726)3.09409365
63double-strand break repair via nonhomologous end joining (GO:0006303)3.09409365
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08069324
65regulation of mitotic spindle checkpoint (GO:1903504)3.08069324
66metaphase plate congression (GO:0051310)3.06694041
67RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05586580
68RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.05275896
69mRNA splicing, via spliceosome (GO:0000398)3.05275896
70DNA replication-independent nucleosome assembly (GO:0006336)3.04439751
71DNA replication-independent nucleosome organization (GO:0034724)3.04439751
72postreplication repair (GO:0006301)3.02999535
73RNA splicing, via transesterification reactions (GO:0000375)3.02414786
74viral mRNA export from host cell nucleus (GO:0046784)3.02040304
75ribosome biogenesis (GO:0042254)2.97909846
76mitotic spindle checkpoint (GO:0071174)2.97794686
77spindle checkpoint (GO:0031577)2.96192356
78spliceosomal complex assembly (GO:0000245)2.96101818
79regulation of chromosome segregation (GO:0051983)2.95386821
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95233372
81negative regulation of DNA-dependent DNA replication (GO:2000104)2.95146758
82nuclear pore complex assembly (GO:0051292)2.93581747
83negative regulation of mRNA processing (GO:0050686)2.93237604
84regulation of DNA endoreduplication (GO:0032875)2.92835100
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92499490
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91654848
87regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87697054
88establishment of chromosome localization (GO:0051303)2.87212756
89L-serine metabolic process (GO:0006563)2.87056369
90negative regulation of histone methylation (GO:0031061)2.86707625
91tRNA aminoacylation for protein translation (GO:0006418)2.86580715
92snRNA processing (GO:0016180)2.86395581
93DNA topological change (GO:0006265)2.85530083
94regulation of mitotic sister chromatid separation (GO:0010965)2.84739398
95regulation of mitotic sister chromatid segregation (GO:0033047)2.84739398
96regulation of sister chromatid segregation (GO:0033045)2.84739398
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82962257
98pseudouridine synthesis (GO:0001522)2.82598543
99peptidyl-histidine modification (GO:0018202)2.82384275
100ribosome assembly (GO:0042255)2.82284170
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81763585
102regulation of helicase activity (GO:0051095)2.80292593
103tRNA aminoacylation (GO:0043039)2.80071859
104amino acid activation (GO:0043038)2.80071859
105replication fork processing (GO:0031297)2.79376782
106histone exchange (GO:0043486)2.76805539
107mismatch repair (GO:0006298)2.75882487
108establishment of protein localization to mitochondrial membrane (GO:0090151)2.75271686
109regulation of gene silencing by RNA (GO:0060966)2.74292745
110regulation of posttranscriptional gene silencing (GO:0060147)2.74292745
111regulation of gene silencing by miRNA (GO:0060964)2.74292745
112ATP-dependent chromatin remodeling (GO:0043044)2.73898137
113ncRNA catabolic process (GO:0034661)2.73785200
114mitotic sister chromatid cohesion (GO:0007064)2.73371827
115regulation of centrosome duplication (GO:0010824)2.72494210
116regulation of spindle organization (GO:0090224)2.72483699
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72450742
118maturation of 5.8S rRNA (GO:0000460)2.72026842
119regulation of translational fidelity (GO:0006450)2.71951240
120kinetochore organization (GO:0051383)2.71910967
121telomere maintenance via telomerase (GO:0007004)2.71580907
122rRNA modification (GO:0000154)2.71279389
123neural tube formation (GO:0001841)2.69794745
124negative regulation of DNA recombination (GO:0045910)2.67031235
125mitochondrial RNA metabolic process (GO:0000959)2.66855238
126glycine metabolic process (GO:0006544)2.64476705
127ribonucleoprotein complex disassembly (GO:0032988)2.63773837
128somatic recombination of immunoglobulin gene segments (GO:0016447)2.63448131
129positive regulation of histone H3-K4 methylation (GO:0051571)2.63015943
130sister chromatid cohesion (GO:0007062)2.60390879
131glutamine metabolic process (GO:0006541)2.59960203
132regulation of centrosome cycle (GO:0046605)2.57962989
133intra-S DNA damage checkpoint (GO:0031573)2.57741434
134rRNA methylation (GO:0031167)2.56680379
135somatic diversification of immunoglobulins (GO:0016445)2.50564495
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48541803
137regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.48465498
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48197371
139recombinational repair (GO:0000725)2.48144428
140DNA catabolic process, exonucleolytic (GO:0000738)2.47411885
141double-strand break repair via homologous recombination (GO:0000724)2.47049565
142rRNA catabolic process (GO:0016075)2.46786108
143nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44163941
144synapsis (GO:0007129)2.42510418
145response to X-ray (GO:0010165)2.42381464
146somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.40959374
147somatic cell DNA recombination (GO:0016444)2.40959374
148somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.39165366
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.39165366
150isotype switching (GO:0045190)2.39165366
151pre-miRNA processing (GO:0031054)2.37871257
152regulation of nuclear cell cycle DNA replication (GO:0033262)2.37502000
153tRNA metabolic process (GO:0006399)2.37097373
154DNA damage response, detection of DNA damage (GO:0042769)2.36595339
155ribosomal large subunit biogenesis (GO:0042273)2.36318435
156resolution of meiotic recombination intermediates (GO:0000712)2.35284760
157DNA-dependent DNA replication (GO:0006261)2.34457197
158proteasome assembly (GO:0043248)2.34395094
159termination of RNA polymerase II transcription (GO:0006369)2.33758840
160somatic diversification of immune receptors (GO:0002200)2.33528589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.30695870
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.29301912
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71234283
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.59445061
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56218869
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20148615
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09814214
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06248174
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.98588745
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87292214
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84925925
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.74736668
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74477261
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69600055
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.59873105
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56232600
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54054624
18* XRN2_22483619_ChIP-Seq_HELA_Human2.53592917
19FUS_26573619_Chip-Seq_HEK293_Human2.48928257
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40172955
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38021117
22YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30140049
23* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30052571
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28286703
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27838428
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21032857
27CIITA_25753668_ChIP-Seq_RAJI_Human2.17355360
28IGF1R_20145208_ChIP-Seq_DFB_Human2.16475678
29ZNF274_21170338_ChIP-Seq_K562_Hela2.16228328
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12604842
31* VDR_23849224_ChIP-Seq_CD4+_Human2.11055649
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07474467
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05550276
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01534905
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99116702
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98541035
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96236619
38* TTF2_22483619_ChIP-Seq_HELA_Human1.95848643
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95632520
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.95116045
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93673684
42GABP_19822575_ChIP-Seq_HepG2_Human1.93614798
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90267431
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.84627778
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.84519141
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84273095
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81805419
48VDR_22108803_ChIP-Seq_LS180_Human1.80633084
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78213879
50AR_21909140_ChIP-Seq_LNCAP_Human1.74904624
51DCP1A_22483619_ChIP-Seq_HELA_Human1.74085219
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71947131
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.67531132
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60746960
55ELK1_19687146_ChIP-ChIP_HELA_Human1.56718583
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55613168
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55590351
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55041293
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54929278
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.53619006
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.52905800
62TAF15_26573619_Chip-Seq_HEK293_Human1.50873137
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50357402
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.50079347
65GBX2_23144817_ChIP-Seq_PC3_Human1.47177252
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47040950
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46086823
68MYC_22102868_ChIP-Seq_BL_Human1.44722790
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44144381
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43032820
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.41357041
72KDM5A_27292631_Chip-Seq_BREAST_Human1.39588665
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39373144
74* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38210604
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37643993
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35627918
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31077709
78P300_19829295_ChIP-Seq_ESCs_Human1.28115972
79IRF1_19129219_ChIP-ChIP_H3396_Human1.27501324
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25023004
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25011269
82* SRF_21415370_ChIP-Seq_HL-1_Mouse1.22638248
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22226351
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20946072
85ER_23166858_ChIP-Seq_MCF-7_Human1.19437094
86MYC_18940864_ChIP-ChIP_HL60_Human1.17801311
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17121421
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16222390
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15601407
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14368964
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11724953
92* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11369505
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11177276
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.08186047
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07709332
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06277924
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05264760
98TFEB_21752829_ChIP-Seq_HELA_Human1.05074518
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04609575
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04585625
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03652440
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03019759
103* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01613623
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.01174012
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00423641
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00274664
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98728984
108CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98269133
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98151943
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93961111
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93301127
112CBP_20019798_ChIP-Seq_JUKART_Human0.93112638
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93112638
114* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92801433
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92062614
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90578308
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88306476
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88299049
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87623335
120SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86900623
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86626045
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85953222
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85695391
124TP53_22573176_ChIP-Seq_HFKS_Human0.84460346
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83656436
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.83284134
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82969117
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82933311
129SOX9_26525672_Chip-Seq_HEART_Mouse0.82894145
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.82205009
131SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80479768
132EWS_26573619_Chip-Seq_HEK293_Human0.79596909
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79201373
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.76642426
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75680229
136HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74346554
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74093040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.23183032
2MP0003693_abnormal_embryo_hatching3.92953503
3MP0003111_abnormal_nucleus_morphology3.64086735
4MP0004957_abnormal_blastocyst_morpholog3.54524822
5MP0003077_abnormal_cell_cycle3.34599813
6MP0003123_paternal_imprinting3.24199366
7MP0008057_abnormal_DNA_replication3.16776095
8MP0008058_abnormal_DNA_repair2.85148926
9MP0003121_genomic_imprinting2.80870873
10MP0008007_abnormal_cellular_replicative2.63205249
11MP0008877_abnormal_DNA_methylation2.61605436
12MP0008932_abnormal_embryonic_tissue2.51285820
13MP0003122_maternal_imprinting2.36867820
14MP0001730_embryonic_growth_arrest2.12198792
15MP0003941_abnormal_skin_development2.06525344
16MP0002102_abnormal_ear_morphology2.03056662
17MP0000350_abnormal_cell_proliferation1.98202176
18MP0002653_abnormal_ependyma_morphology1.87780411
19MP0003890_abnormal_embryonic-extraembry1.84152030
20MP0000537_abnormal_urethra_morphology1.78535366
21MP0008995_early_reproductive_senescence1.75600219
22MP0003787_abnormal_imprinting1.69808130
23MP0001529_abnormal_vocalization1.68169221
24MP0002254_reproductive_system_inflammat1.64430712
25MP0004133_heterotaxia1.59731623
26MP0004859_abnormal_synaptic_plasticity1.58274838
27MP0002084_abnormal_developmental_patter1.57733818
28MP0009697_abnormal_copulation1.57190323
29MP0002085_abnormal_embryonic_tissue1.56190073
30MP0002396_abnormal_hematopoietic_system1.56130166
31MP0001697_abnormal_embryo_size1.53083649
32MP0002080_prenatal_lethality1.45337664
33MP0000372_irregular_coat_pigmentation1.43772398
34MP0006292_abnormal_olfactory_placode1.43655467
35MP0005075_abnormal_melanosome_morpholog1.43387531
36MP0003136_yellow_coat_color1.42354314
37MP0001672_abnormal_embryogenesis/_devel1.40648387
38MP0005380_embryogenesis_phenotype1.40648387
39MP0006054_spinal_hemorrhage1.31315859
40MP0003315_abnormal_perineum_morphology1.29620151
41MP0002233_abnormal_nose_morphology1.29386998
42MP0004197_abnormal_fetal_growth/weight/1.29307371
43MP0000427_abnormal_hair_cycle1.26367799
44MP0003861_abnormal_nervous_system1.25252090
45MP0003119_abnormal_digestive_system1.22825506
46MP0010352_gastrointestinal_tract_polyps1.22457596
47MP0000569_abnormal_digit_pigmentation1.21836320
48MP0002938_white_spotting1.21603932
49MP0000647_abnormal_sebaceous_gland1.19836158
50MP0003984_embryonic_growth_retardation1.19388703
51MP0003942_abnormal_urinary_system1.17778392
52MP0002088_abnormal_embryonic_growth/wei1.15938554
53MP0005408_hypopigmentation1.15802283
54MP0005499_abnormal_olfactory_system1.14833809
55MP0005394_taste/olfaction_phenotype1.14833809
56MP0009053_abnormal_anal_canal1.14340610
57MP0004147_increased_porphyrin_level1.13370549
58MP0002751_abnormal_autonomic_nervous1.13359859
59MP0004233_abnormal_muscle_weight1.12964942
60MP0001286_abnormal_eye_development1.10534364
61MP0003880_abnormal_central_pattern1.10451360
62MP0003718_maternal_effect1.10253000
63MP0000778_abnormal_nervous_system1.10064075
64MP0003786_premature_aging1.09788412
65MP0005253_abnormal_eye_physiology1.08939240
66MP0000313_abnormal_cell_death1.08721663
67MP0002210_abnormal_sex_determination1.07229230
68MP0003283_abnormal_digestive_organ1.04554291
69MP0002234_abnormal_pharynx_morphology1.04104386
70MP0002184_abnormal_innervation1.03687553
71MP0006072_abnormal_retinal_apoptosis1.02802103
72MP0003635_abnormal_synaptic_transmissio1.02011664
73MP0006276_abnormal_autonomic_nervous1.01951507
74MP0000534_abnormal_ureter_morphology1.00376775
75MP0010030_abnormal_orbit_morphology1.00105728
76MP0002736_abnormal_nociception_after0.99683049
77MP0002638_abnormal_pupillary_reflex0.99370809
78MP0002086_abnormal_extraembryonic_tissu0.98325270
79MP0004808_abnormal_hematopoietic_stem0.97942050
80MP0001293_anophthalmia0.97402009
81MP0004811_abnormal_neuron_physiology0.97279258
82MP0005670_abnormal_white_adipose0.95839059
83MP0002697_abnormal_eye_size0.95141091
84MP0006035_abnormal_mitochondrial_morpho0.95058440
85MP0008789_abnormal_olfactory_epithelium0.94849613
86MP0002160_abnormal_reproductive_system0.94544954
87MP0002063_abnormal_learning/memory/cond0.94256587
88MP0000631_abnormal_neuroendocrine_gland0.92906547
89MP0001145_abnormal_male_reproductive0.92191723
90MP0002009_preneoplasia0.92168901
91MP0002111_abnormal_tail_morphology0.91066704
92MP0005646_abnormal_pituitary_gland0.89504922
93MP0004145_abnormal_muscle_electrophysio0.89497105
94MP0001177_atelectasis0.89387199
95MP0002152_abnormal_brain_morphology0.89317408
96MP0005391_vision/eye_phenotype0.88622600
97MP0003935_abnormal_craniofacial_develop0.88319633
98MP0000049_abnormal_middle_ear0.86786425
99MP0001968_abnormal_touch/_nociception0.86270884
100MP0003938_abnormal_ear_development0.85068894
101MP0003937_abnormal_limbs/digits/tail_de0.84107816
102MP0000653_abnormal_sex_gland0.83513662
103MP0003567_abnormal_fetal_cardiomyocyte0.82760211
104MP0010307_abnormal_tumor_latency0.82266163
105MP0000358_abnormal_cell_content/0.82242377
106MP0002822_catalepsy0.81902346
107MP0002019_abnormal_tumor_incidence0.81572100
108MP0005551_abnormal_eye_electrophysiolog0.81047849
109MP0002837_dystrophic_cardiac_calcinosis0.79719861
110MP0005171_absent_coat_pigmentation0.79594246
111MP0000955_abnormal_spinal_cord0.79381105
112MP0002932_abnormal_joint_morphology0.79010958
113MP0001929_abnormal_gametogenesis0.78918203
114MP0004134_abnormal_chest_morphology0.77818923
115MP0002081_perinatal_lethality0.77779023
116MP0002114_abnormal_axial_skeleton0.77689429
117MP0003385_abnormal_body_wall0.77492337
118MP0003646_muscle_fatigue0.77354383
119MP0001299_abnormal_eye_distance/0.76496770
120MP0003698_abnormal_male_reproductive0.75712334
121MP0002735_abnormal_chemical_nociception0.75600396
122MP0008872_abnormal_physiological_respon0.75586029
123MP0005384_cellular_phenotype0.75212545
124MP0000428_abnormal_craniofacial_morphol0.75060056
125MP0005076_abnormal_cell_differentiation0.74995115
126MP0003011_delayed_dark_adaptation0.73880308
127MP0009703_decreased_birth_body0.73443771
128MP0002095_abnormal_skin_pigmentation0.72828433
129MP0003115_abnormal_respiratory_system0.72273650
130MP0002116_abnormal_craniofacial_bone0.72272973
131MP0000678_abnormal_parathyroid_gland0.71915913
132MP0009672_abnormal_birth_weight0.69986112
133MP0005389_reproductive_system_phenotype0.69569334
134MP0005187_abnormal_penis_morphology0.68570643
135MP0002064_seizures0.68254275
136MP0002572_abnormal_emotion/affect_behav0.67317659
137MP0003755_abnormal_palate_morphology0.66052857
138MP0001188_hyperpigmentation0.64733186

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.82077936
2Colon cancer (HP:0003003)3.71498084
3Ependymoma (HP:0002888)3.65625216
4Birth length less than 3rd percentile (HP:0003561)3.36599905
5Medulloblastoma (HP:0002885)3.30253003
6Aplastic anemia (HP:0001915)3.21312996
7Agnosia (HP:0010524)3.08079274
8Selective tooth agenesis (HP:0001592)2.98296295
9Hyperglycinemia (HP:0002154)2.95786170
10Patellar aplasia (HP:0006443)2.86840750
11Abnormality of the astrocytes (HP:0100707)2.81204525
12Astrocytoma (HP:0009592)2.81204525
13Shoulder girdle muscle weakness (HP:0003547)2.78872365
14Aplasia/Hypoplasia of the patella (HP:0006498)2.63915586
15Volvulus (HP:0002580)2.63148948
1611 pairs of ribs (HP:0000878)2.58953045
17Aplasia/Hypoplasia of the sternum (HP:0006714)2.56456664
18Cerebral hypomyelination (HP:0006808)2.56304840
19Abnormal number of incisors (HP:0011064)2.55185481
20Increased nuchal translucency (HP:0010880)2.51651132
21Hypoplasia of the pons (HP:0012110)2.44299642
22Rhabdomyosarcoma (HP:0002859)2.42318424
23Degeneration of anterior horn cells (HP:0002398)2.38632216
24Abnormality of the anterior horn cell (HP:0006802)2.38632216
25Abnormality of serum amino acid levels (HP:0003112)2.33469538
26Proximal placement of thumb (HP:0009623)2.32000347
27Abnormality of glycolysis (HP:0004366)2.28511074
28Increased serum pyruvate (HP:0003542)2.28511074
29Pancreatic cysts (HP:0001737)2.26561289
30Abnormal lung lobation (HP:0002101)2.25486173
31Glioma (HP:0009733)2.24309775
32Hepatoblastoma (HP:0002884)2.24143509
33Atrophy/Degeneration involving motor neurons (HP:0007373)2.22748338
34Oral leukoplakia (HP:0002745)2.22036636
35Deviation of the thumb (HP:0009603)2.21911220
36Pancreatic fibrosis (HP:0100732)2.21549424
37High anterior hairline (HP:0009890)2.20893254
38Abnormality of the lower motor neuron (HP:0002366)2.20074228
39Abnormality of the pons (HP:0007361)2.20009215
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16631388
41Short 4th metacarpal (HP:0010044)2.16631388
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15332088
43Postnatal microcephaly (HP:0005484)2.12915585
44Chromsome breakage (HP:0040012)2.12774241
45Myelodysplasia (HP:0002863)2.11060945
46Reticulocytopenia (HP:0001896)2.10205724
47Hyperglycinuria (HP:0003108)2.09455980
48Abnormality of the ileum (HP:0001549)2.08036053
49Meckel diverticulum (HP:0002245)2.05521809
50Small intestinal stenosis (HP:0012848)2.05133141
51Duodenal stenosis (HP:0100867)2.05133141
52Abnormality of serine family amino acid metabolism (HP:0010894)2.04744637
53Abnormality of glycine metabolism (HP:0010895)2.04744637
54Horseshoe kidney (HP:0000085)2.04269590
55Renal duplication (HP:0000075)2.03028698
56Stenosis of the external auditory canal (HP:0000402)2.02892175
57Missing ribs (HP:0000921)2.02788991
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.01184434
59Abnormality of the carotid arteries (HP:0005344)2.00728257
60Premature graying of hair (HP:0002216)2.00112347
61Amaurosis fugax (HP:0100576)1.99070306
62Esophageal atresia (HP:0002032)1.98969041
63Neoplasm of the pancreas (HP:0002894)1.98599379
64Small hand (HP:0200055)1.96928186
65Abnormality of methionine metabolism (HP:0010901)1.96852037
66Medial flaring of the eyebrow (HP:0010747)1.96763994
67Trigonocephaly (HP:0000243)1.95560281
68Pelvic girdle muscle weakness (HP:0003749)1.95497944
69Genital tract atresia (HP:0001827)1.94871762
70Pancreatic islet-cell hyperplasia (HP:0004510)1.94840733
71Neoplasm of the colon (HP:0100273)1.93394841
72Abnormality of chromosome stability (HP:0003220)1.92899947
73Broad distal phalanx of finger (HP:0009836)1.92819732
74Nephroblastoma (Wilms tumor) (HP:0002667)1.92722609
75Nephronophthisis (HP:0000090)1.92710282
76Absent thumb (HP:0009777)1.92639220
77Neoplasm of the adrenal cortex (HP:0100641)1.92265899
78Acute encephalopathy (HP:0006846)1.92262536
79Ectopic kidney (HP:0000086)1.92071318
80Microglossia (HP:0000171)1.91285572
81Triphalangeal thumb (HP:0001199)1.90811839
82Broad alveolar ridges (HP:0000187)1.89066572
83Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88464016
84Vaginal atresia (HP:0000148)1.87890417
85Neoplasm of the oral cavity (HP:0100649)1.87117347
86Embryonal renal neoplasm (HP:0011794)1.86778149
87Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85156554
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.84950592
89Gastrointestinal atresia (HP:0002589)1.84461690
90Neoplasm of striated muscle (HP:0009728)1.84060510
91Congenital primary aphakia (HP:0007707)1.83201165
92Acute necrotizing encephalopathy (HP:0006965)1.82890619
93Lissencephaly (HP:0001339)1.80884888
94Abnormality of the preputium (HP:0100587)1.80617426
95Microvesicular hepatic steatosis (HP:0001414)1.80437186
96Abnormality of the duodenum (HP:0002246)1.80377357
97Glossoptosis (HP:0000162)1.79422080
98Slender long bone (HP:0003100)1.79364169
99Amyotrophic lateral sclerosis (HP:0007354)1.78423238
100Breast hypoplasia (HP:0003187)1.78060767
101Poor coordination (HP:0002370)1.77847719
102Dandy-Walker malformation (HP:0001305)1.77721665
103Increased CSF lactate (HP:0002490)1.77617110
104Abnormality of cells of the erythroid lineage (HP:0012130)1.77074918
105Abnormality of chromosome segregation (HP:0002916)1.76773198
106Intestinal atresia (HP:0011100)1.76287076
107Atresia of the external auditory canal (HP:0000413)1.75184815
108Facial cleft (HP:0002006)1.74061941
109Supernumerary spleens (HP:0009799)1.73777181
110Increased hepatocellular lipid droplets (HP:0006565)1.73323821
111Broad palm (HP:0001169)1.72833525
112Gait imbalance (HP:0002141)1.72737154
113Long clavicles (HP:0000890)1.72646239
114Neuroblastic tumors (HP:0004376)1.71024303
115Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.71024303
116Neuroblastoma (HP:0003006)1.71024303
117Primitive neuroectodermal tumor (HP:0030065)1.71024303
118Carpal bone hypoplasia (HP:0001498)1.70898193
119Molar tooth sign on MRI (HP:0002419)1.70097869
120Abnormality of midbrain morphology (HP:0002418)1.70097869
121Basal cell carcinoma (HP:0002671)1.70057640
122Breast carcinoma (HP:0003002)1.69401591
123CNS hypomyelination (HP:0003429)1.69169680
124Sloping forehead (HP:0000340)1.67723112
125Nephrogenic diabetes insipidus (HP:0009806)1.67581271
126Bone marrow hypocellularity (HP:0005528)1.67347156
127Lipid accumulation in hepatocytes (HP:0006561)1.67329454
128Abnormal number of erythroid precursors (HP:0012131)1.66727588
129Optic nerve coloboma (HP:0000588)1.66215337
130Freckling (HP:0001480)1.65710595
131Absent epiphyses (HP:0010577)1.65206431
132Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65206431
133Abnormality of the renal medulla (HP:0100957)1.64468438
134Homocystinuria (HP:0002156)1.64266511
135Abnormality of homocysteine metabolism (HP:0010919)1.64266511
136Pointed chin (HP:0000307)1.62069717
137Cellular immunodeficiency (HP:0005374)1.61594888
138Abnormality of the hip-girdle musculature (HP:0001445)1.61327987
139Abnormality of the musculature of the pelvis (HP:0001469)1.61327987
140Methylmalonic acidemia (HP:0002912)1.61283758
141Astigmatism (HP:0000483)1.60841378
142Neoplasm of the rectum (HP:0100743)1.60266726
143Abnormality of DNA repair (HP:0003254)1.59845507
144Sclerocornea (HP:0000647)1.59033910
145Cafe-au-lait spot (HP:0000957)1.58942153
146Intestinal polyposis (HP:0200008)1.58707336
147Hypoplastic pelvis (HP:0008839)1.58269490
1483-Methylglutaconic aciduria (HP:0003535)1.57501379
149Bifid tongue (HP:0010297)1.57399576
150Hypoplastic female external genitalia (HP:0012815)1.57003442
151Bilateral microphthalmos (HP:0007633)1.56696523
152True hermaphroditism (HP:0010459)1.55490136
153Dental crowding (HP:0000678)1.54690386
154Drooling (HP:0002307)1.54359757
155Anencephaly (HP:0002323)1.54198316
156Cerebral edema (HP:0002181)1.53686878
157Broad foot (HP:0001769)1.53198357
158Diastasis recti (HP:0001540)1.53095597
159Septo-optic dysplasia (HP:0100842)1.52952508
160Increased serum lactate (HP:0002151)1.52025148
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.51206326
162Progressive macrocephaly (HP:0004481)1.51066425
163Partial agenesis of the corpus callosum (HP:0001338)1.51029732
164Cupped ear (HP:0000378)1.50742101
165Abnormality of the metopic suture (HP:0005556)1.50429980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.47779143
2BUB14.41012487
3CDC74.39255617
4EEF2K3.76636428
5WEE13.17303827
6NEK12.89451590
7PASK2.81067791
8ZAK2.70678691
9EIF2AK12.44778597
10CCNB12.34728440
11PINK12.13501865
12SRPK12.04423064
13NUAK12.02837877
14RPS6KB22.02427897
15PLK32.00178900
16FRK1.87180278
17MAP3K41.79756178
18DAPK11.74635090
19TGFBR11.74065100
20MKNK11.71740569
21WNK31.70808204
22VRK11.68673799
23ATR1.67533765
24MAP4K21.66190225
25BRSK11.60400021
26TTK1.60271208
27PLK11.59779444
28BMPR1B1.52640933
29SCYL21.52183832
30STK161.49942739
31PBK1.47813397
32MUSK1.44999296
33TNIK1.43330212
34TESK21.42455338
35MAPKAPK31.41896782
36ACVR1B1.40580047
37CDK191.38393503
38NEK21.36564922
39CSNK1G11.31614857
40PLK21.26382329
41BRSK21.26315550
42PNCK1.25603270
43PLK41.22866453
44CASK1.19959931
45CDK71.18058659
46EIF2AK31.14541114
47TAF11.12078142
48MAP2K71.11714499
49CHEK11.10955957
50AURKA1.10399790
51MARK11.08658730
52AURKB1.08558235
53MINK11.07986425
54FGFR21.07468788
55CDK81.07432031
56CAMK1G1.06564975
57NTRK31.05277435
58BRAF1.04556332
59KSR11.03079901
60MAP3K121.02170421
61TRIM281.01317940
62TLK10.99361346
63MAPK130.98312706
64PAK40.96225125
65EIF2AK20.95784179
66CHEK20.92569553
67UHMK10.90413794
68TIE10.88942102
69VRK20.87829397
70MAP3K100.87501358
71BCR0.82584061
72GRK10.82447529
73MKNK20.82311367
74RPS6KA40.82204106
75STK390.81335700
76CDK20.80777280
77CAMK1D0.80640339
78CDK180.80614664
79CLK10.80126765
80NLK0.79405646
81ATM0.73318920
82CDK10.71603098
83CDK150.71442772
84STK30.71331993
85LIMK10.70684195
86DYRK20.70346820
87BRD40.70213870
88ADRBK20.70181769
89CDK11A0.69379141
90SIK30.68859423
91INSRR0.68812219
92OXSR10.66665532
93CDK140.65715336
94CDK30.65533046
95FLT30.65410670
96PDK20.65344223
97CSNK1G30.63558381
98FGFR10.63294232
99ILK0.62621026
100WNK40.60793768
101PIK3CA0.60596180
102MAP3K80.60441015
103CSNK2A20.60311183
104ERBB30.60277231
105DYRK30.60147297
106MST40.56783364
107ALK0.55705993
108RPS6KB10.55342181
109AKT30.55099943
110CSNK1D0.55018320
111NEK60.54687000
112STK38L0.54675734
113PAK10.54031578
114NTRK20.51780694
115CDK40.51582407
116TEC0.45748678
117RPS6KA50.44816789
118PRKCE0.44413663
119MARK30.43910128
120CSNK1E0.43655941
121YES10.43154977
122CSNK1G20.42771515
123MAP3K90.42510248
124DYRK1A0.41021274
125CSNK2A10.39985190
126PRKDC0.39819044
127MAP2K40.38249305
128PDK40.38112883
129PDK30.38112883
130TESK10.37443102
131PRKCI0.36808648
132RPS6KA20.32914613
133CDK120.31683354
134MAPK90.28319229
135LATS20.27510627
136PKN20.25993844
137MAPK140.24439764
138GSK3B0.24254974
139RAF10.23392092
140NME10.22796159
141CSNK1A1L0.22013967
142MAPKAPK50.20992489

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.82300166
2Mismatch repair_Homo sapiens_hsa034304.47864699
3Spliceosome_Homo sapiens_hsa030403.42849277
4RNA transport_Homo sapiens_hsa030133.08119300
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07701448
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.03490189
7Base excision repair_Homo sapiens_hsa034102.87832658
8Proteasome_Homo sapiens_hsa030502.86447320
9Cell cycle_Homo sapiens_hsa041102.76101416
10Nucleotide excision repair_Homo sapiens_hsa034202.75489919
11Homologous recombination_Homo sapiens_hsa034402.70634202
12RNA polymerase_Homo sapiens_hsa030202.51749498
13Propanoate metabolism_Homo sapiens_hsa006402.38037095
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26346831
15One carbon pool by folate_Homo sapiens_hsa006702.25683486
16Ribosome_Homo sapiens_hsa030102.18138993
17mRNA surveillance pathway_Homo sapiens_hsa030152.17952639
18Selenocompound metabolism_Homo sapiens_hsa004502.13438960
19RNA degradation_Homo sapiens_hsa030181.94628874
20Fanconi anemia pathway_Homo sapiens_hsa034601.90249780
21Non-homologous end-joining_Homo sapiens_hsa034501.88892894
22Pyrimidine metabolism_Homo sapiens_hsa002401.88223408
23Butanoate metabolism_Homo sapiens_hsa006501.73349236
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72776065
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70627540
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69820055
27Oocyte meiosis_Homo sapiens_hsa041141.64690475
28Basal transcription factors_Homo sapiens_hsa030221.58619308
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49356922
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37252113
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32664237
32Steroid biosynthesis_Homo sapiens_hsa001001.30308705
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29960732
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27854342
35Lysine degradation_Homo sapiens_hsa003101.21824979
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21391839
37Purine metabolism_Homo sapiens_hsa002301.11283428
38Oxidative phosphorylation_Homo sapiens_hsa001901.11051902
39Epstein-Barr virus infection_Homo sapiens_hsa051691.07158039
40Caffeine metabolism_Homo sapiens_hsa002321.06685922
41p53 signaling pathway_Homo sapiens_hsa041151.03494338
42Colorectal cancer_Homo sapiens_hsa052101.00105170
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97602860
44Alcoholism_Homo sapiens_hsa050340.96247252
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95250749
46N-Glycan biosynthesis_Homo sapiens_hsa005100.94131645
47Protein export_Homo sapiens_hsa030600.93791208
48Nicotine addiction_Homo sapiens_hsa050330.92949993
49Viral carcinogenesis_Homo sapiens_hsa052030.92883001
50Synaptic vesicle cycle_Homo sapiens_hsa047210.91410292
51Biosynthesis of amino acids_Homo sapiens_hsa012300.85433554
52Nitrogen metabolism_Homo sapiens_hsa009100.83031659
53Systemic lupus erythematosus_Homo sapiens_hsa053220.80949750
54Basal cell carcinoma_Homo sapiens_hsa052170.80379728
55Thyroid cancer_Homo sapiens_hsa052160.79391299
56Hippo signaling pathway_Homo sapiens_hsa043900.78131890
57Vitamin B6 metabolism_Homo sapiens_hsa007500.78085519
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76918504
59Fatty acid metabolism_Homo sapiens_hsa012120.76902007
60Fatty acid degradation_Homo sapiens_hsa000710.75195027
61HTLV-I infection_Homo sapiens_hsa051660.72287660
62Hedgehog signaling pathway_Homo sapiens_hsa043400.72227592
63Vibrio cholerae infection_Homo sapiens_hsa051100.71898646
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.71617835
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70794205
66Fatty acid elongation_Homo sapiens_hsa000620.68686546
67beta-Alanine metabolism_Homo sapiens_hsa004100.66103051
68Linoleic acid metabolism_Homo sapiens_hsa005910.65938448
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64874921
70Antigen processing and presentation_Homo sapiens_hsa046120.63691027
71Metabolic pathways_Homo sapiens_hsa011000.62423672
72Dopaminergic synapse_Homo sapiens_hsa047280.62126107
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.61225901
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58825334
75Retinol metabolism_Homo sapiens_hsa008300.58240500
76Peroxisome_Homo sapiens_hsa041460.58161943
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.57876317
78Tryptophan metabolism_Homo sapiens_hsa003800.55976212
79Notch signaling pathway_Homo sapiens_hsa043300.53854328
80MicroRNAs in cancer_Homo sapiens_hsa052060.52953589
81Long-term potentiation_Homo sapiens_hsa047200.52943820
82Wnt signaling pathway_Homo sapiens_hsa043100.52859082
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52637496
84Type I diabetes mellitus_Homo sapiens_hsa049400.49829759
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46836474
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46621989
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46560299
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45329825
89Alzheimers disease_Homo sapiens_hsa050100.44942840
90Regulation of autophagy_Homo sapiens_hsa041400.44933169
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44189876
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44136733
93Shigellosis_Homo sapiens_hsa051310.43812976
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43649763
95Ether lipid metabolism_Homo sapiens_hsa005650.43117646
96Amphetamine addiction_Homo sapiens_hsa050310.42757815
97Gap junction_Homo sapiens_hsa045400.42197133
98Circadian rhythm_Homo sapiens_hsa047100.41975121
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41397501
100Vitamin digestion and absorption_Homo sapiens_hsa049770.39479254
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39443986
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.38735003
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38025273
104Olfactory transduction_Homo sapiens_hsa047400.37363280
105Collecting duct acid secretion_Homo sapiens_hsa049660.37165373
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.36388905
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.36222997
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35968105
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35117078
110Non-small cell lung cancer_Homo sapiens_hsa052230.34669750
111Huntingtons disease_Homo sapiens_hsa050160.34636452
112Endometrial cancer_Homo sapiens_hsa052130.33851517
113Bladder cancer_Homo sapiens_hsa052190.33778401
114mTOR signaling pathway_Homo sapiens_hsa041500.33439827
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32756580
116Long-term depression_Homo sapiens_hsa047300.32555234
117Arginine and proline metabolism_Homo sapiens_hsa003300.32110243
118Sulfur relay system_Homo sapiens_hsa041220.31484083
119Circadian entrainment_Homo sapiens_hsa047130.31107012
120Pathways in cancer_Homo sapiens_hsa052000.30942880
121Melanogenesis_Homo sapiens_hsa049160.30402753
122Arginine biosynthesis_Homo sapiens_hsa002200.29773702
123Cardiac muscle contraction_Homo sapiens_hsa042600.28959145
124GABAergic synapse_Homo sapiens_hsa047270.28547149
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28160436
126Carbon metabolism_Homo sapiens_hsa012000.27960234
127Melanoma_Homo sapiens_hsa052180.27443830
128Glioma_Homo sapiens_hsa052140.26921096
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26739049
130Herpes simplex infection_Homo sapiens_hsa051680.26723584
131TGF-beta signaling pathway_Homo sapiens_hsa043500.26595833
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26577562
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26533947
134Chemical carcinogenesis_Homo sapiens_hsa052040.25973953
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25929545
136Tyrosine metabolism_Homo sapiens_hsa003500.25566385
137Chronic myeloid leukemia_Homo sapiens_hsa052200.25223054
138Parkinsons disease_Homo sapiens_hsa050120.24584456
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24213707
140Morphine addiction_Homo sapiens_hsa050320.23842650
141Phototransduction_Homo sapiens_hsa047440.23174738
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22992794
143Pancreatic cancer_Homo sapiens_hsa052120.22509389
144Legionellosis_Homo sapiens_hsa051340.22291603
145Taste transduction_Homo sapiens_hsa047420.22045705
146Pyruvate metabolism_Homo sapiens_hsa006200.21766888
147ErbB signaling pathway_Homo sapiens_hsa040120.20748062
148Axon guidance_Homo sapiens_hsa043600.19647846
149HIF-1 signaling pathway_Homo sapiens_hsa040660.16713717
150Hepatitis B_Homo sapiens_hsa051610.16439838
151Serotonergic synapse_Homo sapiens_hsa047260.16096409
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14166202

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