ELOVL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.91468026
2keratinization (GO:0031424)7.91230145
3establishment of skin barrier (GO:0061436)7.74305163
4regulation of water loss via skin (GO:0033561)6.65240691
5regulation of rhodopsin mediated signaling pathway (GO:0022400)6.23607406
6rhodopsin mediated signaling pathway (GO:0016056)6.05470315
7hair cycle (GO:0042633)5.64921360
8molting cycle (GO:0042303)5.64921360
9retinal cone cell development (GO:0046549)5.31263586
10detection of light stimulus involved in sensory perception (GO:0050962)4.80242107
11detection of light stimulus involved in visual perception (GO:0050908)4.80242107
12long-chain fatty acid biosynthetic process (GO:0042759)4.58719310
13multicellular organismal water homeostasis (GO:0050891)4.55597378
14pyrimidine nucleobase catabolic process (GO:0006208)4.53627196
15photoreceptor cell development (GO:0042461)4.51156498
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.36030515
17eye photoreceptor cell development (GO:0042462)4.35462066
18photoreceptor cell maintenance (GO:0045494)4.35319070
19peptide cross-linking (GO:0018149)4.19293511
20keratinocyte differentiation (GO:0030216)4.17721266
21protein localization to synapse (GO:0035418)4.10803533
22intermediate filament organization (GO:0045109)4.08998376
23neuron cell-cell adhesion (GO:0007158)3.86314676
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.83589818
25synaptic vesicle exocytosis (GO:0016079)3.81122442
26vocalization behavior (GO:0071625)3.79060169
27gamma-aminobutyric acid transport (GO:0015812)3.77392285
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.76815412
29retinal rod cell development (GO:0046548)3.76418315
30water homeostasis (GO:0030104)3.68555647
31photoreceptor cell differentiation (GO:0046530)3.60254951
32eye photoreceptor cell differentiation (GO:0001754)3.60254951
33glutamate secretion (GO:0014047)3.59985063
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.59780616
35nucleobase catabolic process (GO:0046113)3.59692600
36neurofilament cytoskeleton organization (GO:0060052)3.57818045
37phototransduction (GO:0007602)3.57610564
38* detection of light stimulus (GO:0009583)3.57385442
39synaptic vesicle maturation (GO:0016188)3.56242712
40* detection of visible light (GO:0009584)3.52826547
41regulation of synaptic vesicle exocytosis (GO:2000300)3.46540976
42keratinocyte proliferation (GO:0043616)3.44202377
43phototransduction, visible light (GO:0007603)3.41232598
44positive regulation of guanylate cyclase activity (GO:0031284)3.40063798
45chemosensory behavior (GO:0007635)3.35951087
46regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.34767766
47epidermal cell differentiation (GO:0009913)3.33003532
48behavioral response to nicotine (GO:0035095)3.32857822
49DNA double-strand break processing (GO:0000729)3.32845705
50epidermis development (GO:0008544)3.31297000
51positive regulation of vesicle fusion (GO:0031340)3.28900639
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27740119
53regulation of vesicle fusion (GO:0031338)3.25561169
54neuronal action potential propagation (GO:0019227)3.21941571
55visual perception (GO:0007601)3.20350694
56dendritic spine morphogenesis (GO:0060997)3.20168953
57sensory perception of light stimulus (GO:0050953)3.16922651
58presynaptic membrane assembly (GO:0097105)3.12068140
59synaptic transmission, glutamatergic (GO:0035249)3.11621141
60keratinocyte development (GO:0003334)3.10951417
61sphingoid metabolic process (GO:0046519)3.06944728
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06390305
63neuron recognition (GO:0008038)3.05238931
64regulation of synapse structural plasticity (GO:0051823)3.05198581
65locomotory exploration behavior (GO:0035641)3.05184427
66regulation of glutamate receptor signaling pathway (GO:1900449)3.04981186
67central nervous system projection neuron axonogenesis (GO:0021952)3.03637181
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.02560248
69regulation of ruffle assembly (GO:1900027)3.02350323
70neurotransmitter secretion (GO:0007269)3.01811036
71cerebral cortex radially oriented cell migration (GO:0021799)3.01421365
72layer formation in cerebral cortex (GO:0021819)3.00312169
73dendrite morphogenesis (GO:0048813)2.99436892
74regulation of guanylate cyclase activity (GO:0031282)2.97116763
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96946311
76glutamate receptor signaling pathway (GO:0007215)2.95978005
77regulation of clathrin-mediated endocytosis (GO:2000369)2.94804937
78behavioral response to cocaine (GO:0048148)2.94164502
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93622678
80GMP metabolic process (GO:0046037)2.93495009
81synapse assembly (GO:0007416)2.91136667
82response to histamine (GO:0034776)2.90611423
83regulation of synaptic vesicle transport (GO:1902803)2.89412788
84hemidesmosome assembly (GO:0031581)2.88739537
85cerebellar Purkinje cell differentiation (GO:0021702)2.88044696
86establishment of mitochondrion localization (GO:0051654)2.86126685
87atrial cardiac muscle cell action potential (GO:0086014)2.85601714
88exploration behavior (GO:0035640)2.84998618
89positive regulation of synapse assembly (GO:0051965)2.84210458
90positive regulation of dendritic spine morphogenesis (GO:0061003)2.83451564
91glycosphingolipid biosynthetic process (GO:0006688)2.81787795
92intermediate filament cytoskeleton organization (GO:0045104)2.81317570
93presynaptic membrane organization (GO:0097090)2.80794366
94neuron-neuron synaptic transmission (GO:0007270)2.77639328
95synaptic vesicle docking involved in exocytosis (GO:0016081)2.77270477
96intermediate filament-based process (GO:0045103)2.77104956
97axonal fasciculation (GO:0007413)2.76405175
98postsynaptic membrane organization (GO:0001941)2.75683583
99ionotropic glutamate receptor signaling pathway (GO:0035235)2.75286715
100ectoderm development (GO:0007398)2.70865900
101cellular potassium ion homeostasis (GO:0030007)2.70423510
102* detection of external stimulus (GO:0009581)2.70367492
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69614175
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.68812639
105startle response (GO:0001964)2.68693623
106neurotransmitter transport (GO:0006836)2.68421157
107cell migration in hindbrain (GO:0021535)2.68262374
108substrate-independent telencephalic tangential migration (GO:0021826)2.68009952
109substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.68009952
110positive regulation of membrane potential (GO:0045838)2.66202421
111dendritic spine organization (GO:0097061)2.65993425
112regulation of neurotransmitter secretion (GO:0046928)2.65987274
113* detection of abiotic stimulus (GO:0009582)2.65204638
114detection of bacterium (GO:0016045)2.64752050
115membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62206174
116sphingosine metabolic process (GO:0006670)2.61724017
117regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61270407
118transmission of nerve impulse (GO:0019226)2.60462800
119regulation of neuronal synaptic plasticity (GO:0048168)2.58977598
120retina layer formation (GO:0010842)2.58847497
121regulation of voltage-gated calcium channel activity (GO:1901385)2.58804400
122central nervous system neuron axonogenesis (GO:0021955)2.58064340
123vesicle transport along microtubule (GO:0047496)2.56826114
124innervation (GO:0060384)2.56446949
125calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.56226730
126neurotransmitter-gated ion channel clustering (GO:0072578)2.55776468
127synaptic vesicle endocytosis (GO:0048488)2.55392270
128regulation of phospholipase A2 activity (GO:0032429)2.55019493
129organelle transport along microtubule (GO:0072384)2.54239356
130short-term memory (GO:0007614)2.47245319
131behavioral response to ethanol (GO:0048149)2.46646289
132regulation of postsynaptic membrane potential (GO:0060078)2.46299088
133hippocampus development (GO:0021766)2.45380349
134establishment of vesicle localization (GO:0051650)2.42407457
135regulation of neurotransmitter levels (GO:0001505)2.41721389
136adult walking behavior (GO:0007628)2.40378097
137proline transport (GO:0015824)2.39720496
138sympathetic nervous system development (GO:0048485)2.39500585
139regulation of collateral sprouting (GO:0048670)2.38358581
140ephrin receptor signaling pathway (GO:0048013)2.38296690
141nonmotile primary cilium assembly (GO:0035058)2.37803953
142synapse organization (GO:0050808)2.37670871
143regulation of excitatory postsynaptic membrane potential (GO:0060079)2.36503818
144auditory behavior (GO:0031223)2.36065413
145homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.35981708
146retinal ganglion cell axon guidance (GO:0031290)2.35863069
147neuronal ion channel clustering (GO:0045161)2.35175303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.48074335
2EZH2_22144423_ChIP-Seq_EOC_Human3.78201696
3GBX2_23144817_ChIP-Seq_PC3_Human2.70151615
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62503963
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61260566
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58621430
7IGF1R_20145208_ChIP-Seq_DFB_Human2.55509006
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.53481105
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39408861
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31408755
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28637146
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28637146
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24812433
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21860573
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19316761
16AR_21572438_ChIP-Seq_LNCaP_Human2.19219086
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18578554
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.14601147
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.13298463
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10014979
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08331177
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.02370056
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82961365
24VDR_22108803_ChIP-Seq_LS180_Human1.82044444
25REST_21632747_ChIP-Seq_MESCs_Mouse1.80028121
26TAF15_26573619_Chip-Seq_HEK293_Human1.78932083
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78586058
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73754470
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.72241765
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70029948
31EWS_26573619_Chip-Seq_HEK293_Human1.69689320
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67972716
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62922901
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.60509798
35DROSHA_22980978_ChIP-Seq_HELA_Human1.59599305
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50398464
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49235675
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48591448
39SMAD4_21799915_ChIP-Seq_A2780_Human1.48266188
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.45606840
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45591860
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44021009
43P300_19829295_ChIP-Seq_ESCs_Human1.42494407
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41286814
45RNF2_27304074_Chip-Seq_NSC_Mouse1.38836601
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.37419667
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36703101
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.34541374
49AHR_22903824_ChIP-Seq_MCF-7_Human1.30972944
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30768732
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30768732
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.30343453
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.29876788
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.28842604
55BCAT_22108803_ChIP-Seq_LS180_Human1.28234126
56AR_25329375_ChIP-Seq_VCAP_Human1.25678818
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24879037
58TP53_18474530_ChIP-ChIP_U2OS_Human1.24741884
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23791896
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.22209394
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21921601
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21437790
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.18608380
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18449751
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17695517
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15595579
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14930056
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14286843
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13948076
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.12978157
71* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12222434
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11305549
73CBP_20019798_ChIP-Seq_JUKART_Human1.11305549
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11230476
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10520730
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08905235
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.08278949
78TCF4_23295773_ChIP-Seq_U87_Human1.08221606
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07446323
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07248491
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07012501
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.06701278
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05666358
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.05295152
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05258369
86IRF1_19129219_ChIP-ChIP_H3396_Human1.05023037
87JUN_21703547_ChIP-Seq_K562_Human1.04378540
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.03912188
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03033662
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02804156
91SOX9_26525672_Chip-Seq_HEART_Mouse1.02539649
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01382096
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.00903909
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00568313
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99865458
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99551886
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.99254321
98* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98992999
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98446629
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98405340
101FUS_26573619_Chip-Seq_HEK293_Human0.98160292
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97850553
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97722729
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.97677986
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97035610
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96659890
107TCF4_22108803_ChIP-Seq_LS180_Human0.96653120
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96304269
109FLI1_21867929_ChIP-Seq_TH2_Mouse0.96215069
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95519567
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94645344
112TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94480766
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.94434934
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94338874
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94198154
116CTCF_27219007_Chip-Seq_Bcells_Human0.94108232
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93455565
118RXR_22108803_ChIP-Seq_LS180_Human0.92160152
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92079564
120STAT3_23295773_ChIP-Seq_U87_Human0.91687874
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91389748
122* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90932363
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90584201
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89339479
125ZNF274_21170338_ChIP-Seq_K562_Hela0.89282532
126* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88702727
127RUNX2_22187159_ChIP-Seq_PCA_Human0.88194157
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87137494
129TP53_16413492_ChIP-PET_HCT116_Human0.87018900
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86656248
131* TP63_23658742_ChIP-Seq_EP156T_Human0.86597604
132* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86161313
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86060993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier5.43431979
2* MP0005551_abnormal_eye_electrophysiolog3.87609397
3MP0003011_delayed_dark_adaptation3.65447563
4MP0000579_abnormal_nail_morphology3.64049458
5MP0010234_abnormal_vibrissa_follicle3.51330128
6MP0005275_abnormal_skin_tensile3.45747571
7* MP0005501_abnormal_skin_physiology3.14439609
8MP0003880_abnormal_central_pattern3.09741109
9MP0006072_abnormal_retinal_apoptosis2.81480421
10MP0004859_abnormal_synaptic_plasticity2.74325608
11MP0003941_abnormal_skin_development2.68767773
12MP0004381_abnormal_hair_follicle2.64307381
13MP0005253_abnormal_eye_physiology2.58530571
14MP0003787_abnormal_imprinting2.53664231
15MP0004270_analgesia2.40283685
16MP0008877_abnormal_DNA_methylation2.29694459
17MP0003122_maternal_imprinting2.25790749
18MP0003635_abnormal_synaptic_transmissio2.18675678
19MP0001984_abnormal_olfaction2.16356111
20MP0000647_abnormal_sebaceous_gland2.10548600
21MP0005423_abnormal_somatic_nervous2.07722879
22* MP0010771_integument_phenotype2.04947506
23MP0010678_abnormal_skin_adnexa1.95630925
24* MP0001216_abnormal_epidermal_layer1.95007525
25MP0009046_muscle_twitch1.93364188
26MP0000467_abnormal_esophagus_morphology1.93224512
27MP0006292_abnormal_olfactory_placode1.89853392
28MP0000383_abnormal_hair_follicle1.87570515
29MP0001188_hyperpigmentation1.85369443
30MP0001968_abnormal_touch/_nociception1.84613792
31MP0009745_abnormal_behavioral_response1.77411362
32MP0002063_abnormal_learning/memory/cond1.76911684
33MP0003121_genomic_imprinting1.75127441
34MP0002064_seizures1.72969365
35MP0000427_abnormal_hair_cycle1.68754563
36MP0002098_abnormal_vibrissa_morphology1.68727530
37MP0002734_abnormal_mechanical_nocicepti1.68335105
38MP0002102_abnormal_ear_morphology1.65657958
39MP0002254_reproductive_system_inflammat1.65494046
40MP0003890_abnormal_embryonic-extraembry1.63148845
41MP0002060_abnormal_skin_morphology1.57606872
42MP0002572_abnormal_emotion/affect_behav1.51575864
43MP0002272_abnormal_nervous_system1.51543019
44MP0001486_abnormal_startle_reflex1.48240794
45MP0005451_abnormal_body_composition1.48099941
46* MP0005195_abnormal_posterior_eye1.46436785
47MP0002184_abnormal_innervation1.43513926
48MP0002736_abnormal_nociception_after1.40716696
49MP0003950_abnormal_plasma_membrane1.40168460
50MP0000377_abnormal_hair_follicle1.35026399
51MP0000778_abnormal_nervous_system1.34667420
52MP0002735_abnormal_chemical_nociception1.33278901
53MP0005409_darkened_coat_color1.32828858
54MP0000762_abnormal_tongue_morphology1.29006973
55MP0001346_abnormal_lacrimal_gland1.28835762
56* MP0002882_abnormal_neuron_morphology1.25452932
57MP0004885_abnormal_endolymph1.22021229
58MP0002638_abnormal_pupillary_reflex1.21778174
59MP0000569_abnormal_digit_pigmentation1.21676523
60MP0002067_abnormal_sensory_capabilities1.21525557
61* MP0002752_abnormal_somatic_nervous1.20465206
62MP0003453_abnormal_keratinocyte_physiol1.18761477
63MP0003329_amyloid_beta_deposits1.17785036
64* MP0002229_neurodegeneration1.16663444
65MP0000566_synostosis1.16194717
66MP0002733_abnormal_thermal_nociception1.14419600
67MP0008569_lethality_at_weaning1.13885412
68MP0005187_abnormal_penis_morphology1.13054596
69MP0002751_abnormal_autonomic_nervous1.11448358
70MP0006276_abnormal_autonomic_nervous1.10598492
71MP0004947_skin_inflammation1.09640294
72MP0001440_abnormal_grooming_behavior1.08073643
73* MP0002090_abnormal_vision1.08066270
74MP0005499_abnormal_olfactory_system1.07485075
75MP0005394_taste/olfaction_phenotype1.07485075
76MP0000049_abnormal_middle_ear1.07453843
77MP0001970_abnormal_pain_threshold1.07069106
78MP0001501_abnormal_sleep_pattern1.04530079
79MP0004858_abnormal_nervous_system1.04129371
80MP0001502_abnormal_circadian_rhythm1.01430860
81MP0003861_abnormal_nervous_system1.01314599
82MP0001299_abnormal_eye_distance/1.01201068
83MP0002557_abnormal_social/conspecific_i1.00873876
84MP0003119_abnormal_digestive_system1.00101197
85MP0002152_abnormal_brain_morphology0.99561362
86MP0002233_abnormal_nose_morphology0.98785625
87* MP0005391_vision/eye_phenotype0.98288714
88MP0005646_abnormal_pituitary_gland0.96689290
89MP0002234_abnormal_pharynx_morphology0.95046192
90* MP0001324_abnormal_eye_pigmentation0.94354804
91MP0004742_abnormal_vestibular_system0.94204644
92MP0002909_abnormal_adrenal_gland0.93398628
93MP0009379_abnormal_foot_pigmentation0.92487387
94MP0008057_abnormal_DNA_replication0.91393337
95MP0008789_abnormal_olfactory_epithelium0.89895183
96MP0001905_abnormal_dopamine_level0.88695360
97MP0003937_abnormal_limbs/digits/tail_de0.87384791
98MP0004142_abnormal_muscle_tone0.86266702
99MP0004133_heterotaxia0.84464566
100MP0004811_abnormal_neuron_physiology0.84013151
101MP0000955_abnormal_spinal_cord0.83385764
102MP0003718_maternal_effect0.79531103
103MP0003938_abnormal_ear_development0.78853626
104MP0004185_abnormal_adipocyte_glucose0.78783080
105MP0005248_abnormal_Harderian_gland0.78407434
106MP0003755_abnormal_palate_morphology0.78339986
107MP0005386_behavior/neurological_phenoty0.78204237
108MP0004924_abnormal_behavior0.78204237
109MP0009780_abnormal_chondrocyte_physiolo0.78046694
110MP0002069_abnormal_eating/drinking_beha0.77208027
111MP0010030_abnormal_orbit_morphology0.76994955
112MP0001529_abnormal_vocalization0.76956319
113MP0001340_abnormal_eyelid_morphology0.75518809
114MP0003567_abnormal_fetal_cardiomyocyte0.74168783
115MP0002822_catalepsy0.73891687
116* MP0009931_abnormal_skin_appearance0.71702894
117MP0006035_abnormal_mitochondrial_morpho0.71345384
118MP0002095_abnormal_skin_pigmentation0.71317823
119MP0002177_abnormal_outer_ear0.71099652
120MP0001177_atelectasis0.70856537
121MP0000367_abnormal_coat/_hair0.69557244
122MP0003634_abnormal_glial_cell0.69165905
123MP0003136_yellow_coat_color0.67525023
124* MP0002066_abnormal_motor_capabilities/c0.66928358
125* MP0001191_abnormal_skin_condition0.66338512
126MP0001986_abnormal_taste_sensitivity0.65290722
127MP0004782_abnormal_surfactant_physiolog0.64953100
128MP0010386_abnormal_urinary_bladder0.63943775
129MP0004145_abnormal_muscle_electrophysio0.62626319
130MP0000751_myopathy0.60428311
131MP0008004_abnormal_stomach_pH0.59129108
132MP0000631_abnormal_neuroendocrine_gland0.56274458

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.84863029
2Abnormality of nail color (HP:0100643)6.17363193
3Bony spicule pigmentary retinopathy (HP:0007737)5.87310019
4Abnormal rod and cone electroretinograms (HP:0008323)5.49611713
5Absent rod-and cone-mediated responses on ERG (HP:0007688)5.29986286
6Hypotrichosis (HP:0001006)4.85794303
7Chorioretinal atrophy (HP:0000533)4.64678731
8Central scotoma (HP:0000603)4.47039077
9Pigmentary retinal degeneration (HP:0001146)4.44245210
10Abnormality of macular pigmentation (HP:0008002)4.43668266
11Increased IgE level (HP:0003212)4.30114079
12Palmoplantar hyperkeratosis (HP:0000972)4.20561515
13Congenital ichthyosiform erythroderma (HP:0007431)4.19924926
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.17441993
15Plantar hyperkeratosis (HP:0007556)4.05859442
16Pendular nystagmus (HP:0012043)3.98130037
17Dyschromatopsia (HP:0007641)3.92236858
18Palmar hyperkeratosis (HP:0010765)3.90382427
19Scotoma (HP:0000575)3.85714716
20Attenuation of retinal blood vessels (HP:0007843)3.77159231
21Limb dystonia (HP:0002451)3.70526296
22Woolly hair (HP:0002224)3.70413083
23Parakeratosis (HP:0001036)3.68283139
24Abolished electroretinogram (ERG) (HP:0000550)3.63839697
25Thick nail (HP:0001805)3.62139540
26Focal motor seizures (HP:0011153)3.53065895
27Decreased central vision (HP:0007663)3.47964419
28Erythroderma (HP:0001019)3.33089749
29Fragile nails (HP:0001808)3.28965123
30Onycholysis (HP:0001806)3.19569938
31Febrile seizures (HP:0002373)3.09524641
32Photophobia (HP:0000613)3.04848539
33Abnormality of the labia minora (HP:0012880)3.00185628
34Conjunctival hamartoma (HP:0100780)2.86941174
35Type II diabetes mellitus (HP:0005978)2.84848763
36Drooling (HP:0002307)2.83884139
37Increased corneal curvature (HP:0100692)2.82687639
38Keratoconus (HP:0000563)2.82687639
39Choroideremia (HP:0001139)2.78485691
40Progressive cerebellar ataxia (HP:0002073)2.77575492
41Epileptic encephalopathy (HP:0200134)2.74072702
42Severe visual impairment (HP:0001141)2.72280892
43* Erythema (HP:0010783)2.72017979
44Focal seizures (HP:0007359)2.71936686
45Right ventricular cardiomyopathy (HP:0011663)2.71364245
46Lip pit (HP:0100267)2.69277656
47Atonic seizures (HP:0010819)2.61477825
48Myokymia (HP:0002411)2.60449552
49Vitreoretinal degeneration (HP:0000655)2.58081576
50Curly hair (HP:0002212)2.58057507
51Excessive salivation (HP:0003781)2.53239570
52Abnormal blistering of the skin (HP:0008066)2.49045365
53Cortical dysplasia (HP:0002539)2.48866312
54Amyotrophic lateral sclerosis (HP:0007354)2.45046587
55Gait imbalance (HP:0002141)2.43593259
56Retinitis pigmentosa (HP:0000510)2.43124186
57Labial hypoplasia (HP:0000066)2.41982181
58Cone-rod dystrophy (HP:0000548)2.41557958
59Corneal dystrophy (HP:0001131)2.41342723
60Pili torti (HP:0003777)2.39503237
61Slow-growing hair (HP:0002217)2.36570505
62Abnormality of hair growth rate (HP:0011363)2.36570505
63Urinary urgency (HP:0000012)2.31863614
64Split foot (HP:0001839)2.31311435
65Absent eyelashes (HP:0000561)2.29895410
66* Macular degeneration (HP:0000608)2.28665709
67Absence seizures (HP:0002121)2.27901469
68Milia (HP:0001056)2.25869079
69Brittle hair (HP:0002299)2.24748494
70Hypoplastic female external genitalia (HP:0012815)2.23274589
71Corneal erosion (HP:0200020)2.21909766
72Action tremor (HP:0002345)2.21865197
73Visual hallucinations (HP:0002367)2.20924183
74Impaired vibration sensation in the lower limbs (HP:0002166)2.19625860
75Absent hair (HP:0002298)2.18434634
76Posterior subcapsular cataract (HP:0007787)2.17900634
77* Hypohidrosis (HP:0000966)2.16080570
78Hamartoma of the eye (HP:0010568)2.15862583
79Abnormality of the corticospinal tract (HP:0002492)2.15818840
80Congenital primary aphakia (HP:0007707)2.15301696
81Abnormality of the lower motor neuron (HP:0002366)2.13126756
82Epileptiform EEG discharges (HP:0011182)2.11554938
83Polyphagia (HP:0002591)2.11373901
84Sleep apnea (HP:0010535)2.11347956
85Hypsarrhythmia (HP:0002521)2.08069341
86Dialeptic seizures (HP:0011146)2.06121279
87Nail dystrophy (HP:0008404)2.06051322
88EEG with generalized epileptiform discharges (HP:0011198)2.06032242
89Specific learning disability (HP:0001328)2.05850670
90Generalized tonic-clonic seizures (HP:0002069)2.05450682
91Hypoplastic labia majora (HP:0000059)2.04075154
92Palmoplantar keratoderma (HP:0000982)2.03413777
93Ventricular fibrillation (HP:0001663)2.02030108
94Vaginal atresia (HP:0000148)2.01116519
95Genital tract atresia (HP:0001827)1.96354460
96Pachygyria (HP:0001302)1.96156022
97Optic nerve hypoplasia (HP:0000609)1.96008524
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93629713
99Sparse scalp hair (HP:0002209)1.93321285
100Concave nail (HP:0001598)1.91271022
101Medial flaring of the eyebrow (HP:0010747)1.89656985
102Nephrogenic diabetes insipidus (HP:0009806)1.88433223
103Natal tooth (HP:0000695)1.87943732
104Atrophy/Degeneration involving motor neurons (HP:0007373)1.87232266
105Optic disc pallor (HP:0000543)1.86266245
106Alopecia of scalp (HP:0002293)1.85965324
107Hypodontia (HP:0000668)1.85769159
108Lissencephaly (HP:0001339)1.85013608
109Gangrene (HP:0100758)1.84303178
110Autoamputation (HP:0001218)1.84285114
111Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83715324
112Degeneration of the lateral corticospinal tracts (HP:0002314)1.83715324
113Hyporeflexia of lower limbs (HP:0002600)1.83334243
114Ectropion (HP:0000656)1.83079658
115Supranuclear gaze palsy (HP:0000605)1.82606030
116Gaze-evoked nystagmus (HP:0000640)1.82597242
117Inability to walk (HP:0002540)1.82537149
118Constricted visual fields (HP:0001133)1.81340980
119Abnormal eating behavior (HP:0100738)1.81063991
120Poor suck (HP:0002033)1.80833822
121Abnormality of the axillary hair (HP:0100134)1.80510957
122Abnormality of secondary sexual hair (HP:0009888)1.80510957
123Truncal ataxia (HP:0002078)1.79806556
124Septo-optic dysplasia (HP:0100842)1.79390425
125Advanced eruption of teeth (HP:0006288)1.79263091
126Abnormality of the labia (HP:0000058)1.78357352
127Abnormality of the labia majora (HP:0012881)1.78260168
128Ulnar claw (HP:0001178)1.77704731
129Broad-based gait (HP:0002136)1.76740714
130Morphological abnormality of the pyramidal tract (HP:0002062)1.75380912
131Hyperthyroidism (HP:0000836)1.75247489
132Follicular hyperkeratosis (HP:0007502)1.74273317
133Hypothermia (HP:0002045)1.73722703
134Volvulus (HP:0002580)1.73592851
135Abnormal hair laboratory examination (HP:0003328)1.73529238
136Ankle clonus (HP:0011448)1.73254980
137Congenital sensorineural hearing impairment (HP:0008527)1.72248633
138Failure to thrive in infancy (HP:0001531)1.70541441
139Oligodactyly (hands) (HP:0001180)1.70119253
140* Asthma (HP:0002099)1.70081955
141Spastic gait (HP:0002064)1.69378226
142Poor coordination (HP:0002370)1.68032579
143Torticollis (HP:0000473)1.67157630
144Hepatoblastoma (HP:0002884)1.67138453
145Laryngomalacia (HP:0001601)1.67130633
146Amblyopia (HP:0000646)1.66847506
147* Spastic tetraplegia (HP:0002510)1.66669721
148Abnormality of salivation (HP:0100755)1.65845934
149Mutism (HP:0002300)1.64677794
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63613004
151Abnormal hair whorl (HP:0010721)1.63054863
152Growth hormone deficiency (HP:0000824)1.62510061
153Absent eyebrow (HP:0002223)1.61985778
154Oral leukoplakia (HP:0002745)1.60974079
155Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.59351736
156* Dysdiadochokinesis (HP:0002075)1.57262618
157Abnormality of the astrocytes (HP:0100707)1.56774363
158Astrocytoma (HP:0009592)1.56774363
159Micropenis (HP:0000054)1.56524793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.96384888
2MARK13.33110746
3TRIM283.23722277
4NTRK33.04506012
5GRK12.88319757
6EPHA42.85934960
7MAP3K92.74772365
8NTRK22.62996125
9WNK32.54829113
10MINK12.31173264
11FER2.24482346
12MST1R2.22366105
13BCR2.13509220
14MAP4K22.07921293
15MAP3K42.05767065
16MAP3K122.04938819
17MAP2K71.78245342
18CSNK1G31.73733295
19MAP2K41.70756074
20CSNK1A1L1.61816103
21PAK61.58489153
22GRK51.50678759
23CSNK1G11.50516142
24STK241.49325777
25PLK21.48448253
26MAPK131.45286695
27MAP3K21.41974573
28ERBB31.39781357
29PHKG11.33702632
30PHKG21.33702632
31TNIK1.31885179
32RIPK41.30840909
33PNCK1.30200600
34MAPKAPK31.26983834
35CDK191.26601630
36CDK51.24803378
37DYRK31.24799603
38PBK1.22728830
39CAMKK21.20969756
40SRPK11.17485832
41FRK1.16903098
42OXSR11.12199002
43STK111.10313268
44MST41.09854896
45PKN11.09380097
46DYRK1A1.08252594
47PAK31.06810524
48FGFR21.06359996
49DAPK21.05507852
50KSR11.05489549
51NTRK11.03509821
52PRKCG1.03370539
53CAMK2A1.02339019
54ADRBK11.00591980
55TAF11.00380765
56LATS20.98256513
57BRSK20.95373640
58KSR20.94560745
59NME10.93593171
60PRKCE0.91247558
61IRAK20.90421721
62STK390.89383294
63SIK20.89083906
64EPHB20.88628008
65ARAF0.88442631
66SGK4940.87034507
67SGK2230.87034507
68DYRK20.85182723
69TYRO30.82566754
70WEE10.82532029
71MAPKAPK50.81985389
72GRK70.81439953
73MKNK20.80494614
74BRSK10.79897556
75TSSK60.77535637
76UHMK10.77523724
77PRPF4B0.76757097
78CDK30.76584964
79FES0.73397354
80BMPR20.72814846
81ZAK0.71711042
82CDK140.70385952
83FGR0.69488992
84MAPK120.68005137
85PLK30.67529881
86LIMK10.67090287
87TGFBR10.66685966
88ROCK20.66331821
89FGFR10.64415514
90RPS6KA40.64245060
91BMPR1B0.63522402
92CDK180.62002961
93DYRK1B0.61848279
94MAP3K60.61753038
95CSNK1E0.60889576
96TAOK10.60400723
97MARK20.59370582
98PRKCZ0.57732805
99CSNK1G20.57364252
100BRD40.56766324
101CDK150.56442416
102ADRBK20.56260041
103STK38L0.55810233
104BRAF0.55605997
105PINK10.54965789
106SGK10.54601215
107TTK0.54113962
108CAMK40.52853880
109MAP3K10.52670657
110CAMK2B0.52418493
111STK380.52384211
112CAMKK10.51221586
113CAMK1G0.50740699
114MAP2K10.50273326
115NEK60.49680020
116PRKACA0.49559077
117CDK11A0.49094779
118OBSCN0.48555256
119CAMK2D0.48263675
120CSNK1D0.48228410
121SGK20.47832659
122MAP2K60.47489077
123SIK30.47386285
124MKNK10.47170727
125TESK10.46907669
126PLK10.45899131
127ROCK10.45686149
128CSNK1A10.45211309
129PIM20.44986721
130PRKCB0.42583210
131PRKCH0.42554585
132WNK10.42338456
133CAMK10.42201288
134LATS10.41338108
135PIK3CG0.40463645
136CDC70.39799242
137RPS6KA30.38405508
138BCKDK0.37038119
139AURKA0.36535216

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.90799140
2Synaptic vesicle cycle_Homo sapiens_hsa047212.97559681
3Nicotine addiction_Homo sapiens_hsa050332.72392400
4Olfactory transduction_Homo sapiens_hsa047402.35266037
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24051940
6GABAergic synapse_Homo sapiens_hsa047272.22028858
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16695166
8Glutamatergic synapse_Homo sapiens_hsa047242.04319793
9Collecting duct acid secretion_Homo sapiens_hsa049662.04220101
10Serotonergic synapse_Homo sapiens_hsa047262.00019702
11Circadian entrainment_Homo sapiens_hsa047131.99142215
12Protein export_Homo sapiens_hsa030601.88580948
13Long-term potentiation_Homo sapiens_hsa047201.79574454
14Morphine addiction_Homo sapiens_hsa050321.78256524
15Dopaminergic synapse_Homo sapiens_hsa047281.77328705
16Cholinergic synapse_Homo sapiens_hsa047251.56474533
17Amphetamine addiction_Homo sapiens_hsa050311.54498218
18Salivary secretion_Homo sapiens_hsa049701.52506578
19Renin secretion_Homo sapiens_hsa049241.49925402
20Axon guidance_Homo sapiens_hsa043601.48196472
21Long-term depression_Homo sapiens_hsa047301.48103381
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42471608
23Taste transduction_Homo sapiens_hsa047421.40871300
24Basal transcription factors_Homo sapiens_hsa030221.35645579
25Oxytocin signaling pathway_Homo sapiens_hsa049211.30795849
26Sphingolipid metabolism_Homo sapiens_hsa006001.29692701
27Gastric acid secretion_Homo sapiens_hsa049711.29538100
28Regulation of autophagy_Homo sapiens_hsa041401.27853824
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26745152
30GnRH signaling pathway_Homo sapiens_hsa049121.25482006
31Insulin secretion_Homo sapiens_hsa049111.23276292
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.20729044
33Calcium signaling pathway_Homo sapiens_hsa040201.19797139
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18956967
35Vibrio cholerae infection_Homo sapiens_hsa051101.16899934
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13863636
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07062037
38Ether lipid metabolism_Homo sapiens_hsa005651.03168390
39Cardiac muscle contraction_Homo sapiens_hsa042601.01240351
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00228374
41Cocaine addiction_Homo sapiens_hsa050300.99001697
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97728673
43Linoleic acid metabolism_Homo sapiens_hsa005910.97067093
44Cell cycle_Homo sapiens_hsa041100.95183445
45Melanogenesis_Homo sapiens_hsa049160.92077607
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91989530
47Oxidative phosphorylation_Homo sapiens_hsa001900.91569207
48Gap junction_Homo sapiens_hsa045400.91264461
49ErbB signaling pathway_Homo sapiens_hsa040120.90008584
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89458755
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88552967
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86640538
53cAMP signaling pathway_Homo sapiens_hsa040240.86384739
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.85658758
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84644439
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83463388
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83184236
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83099180
59Huntingtons disease_Homo sapiens_hsa050160.82259547
60Ras signaling pathway_Homo sapiens_hsa040140.81680938
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81515059
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79918901
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78398278
64Pancreatic secretion_Homo sapiens_hsa049720.77592193
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76228807
66Alzheimers disease_Homo sapiens_hsa050100.75696829
67mRNA surveillance pathway_Homo sapiens_hsa030150.74430777
68Glioma_Homo sapiens_hsa052140.71701119
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.70496481
70Estrogen signaling pathway_Homo sapiens_hsa049150.70420726
71RNA degradation_Homo sapiens_hsa030180.67958677
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66851917
73Tight junction_Homo sapiens_hsa045300.64060283
74VEGF signaling pathway_Homo sapiens_hsa043700.63028076
75Circadian rhythm_Homo sapiens_hsa047100.62891571
76Folate biosynthesis_Homo sapiens_hsa007900.61944700
77RNA transport_Homo sapiens_hsa030130.59878060
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59873508
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59792944
80Fanconi anemia pathway_Homo sapiens_hsa034600.59719017
81Hedgehog signaling pathway_Homo sapiens_hsa043400.57307388
82Arachidonic acid metabolism_Homo sapiens_hsa005900.57154778
83MAPK signaling pathway_Homo sapiens_hsa040100.54062515
84Non-homologous end-joining_Homo sapiens_hsa034500.53772505
85RNA polymerase_Homo sapiens_hsa030200.52748074
86Wnt signaling pathway_Homo sapiens_hsa043100.51992593
87Dilated cardiomyopathy_Homo sapiens_hsa054140.51917951
88Choline metabolism in cancer_Homo sapiens_hsa052310.50962289
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50738843
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50139313
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49543580
92Dorso-ventral axis formation_Homo sapiens_hsa043200.49064223
93Alcoholism_Homo sapiens_hsa050340.48636560
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.48412470
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47976746
96Butanoate metabolism_Homo sapiens_hsa006500.47225678
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43082939
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42742761
99Renal cell carcinoma_Homo sapiens_hsa052110.42450307
100Basal cell carcinoma_Homo sapiens_hsa052170.41960445
101Propanoate metabolism_Homo sapiens_hsa006400.41940393
102Rheumatoid arthritis_Homo sapiens_hsa053230.41463856
103Mismatch repair_Homo sapiens_hsa034300.41312691
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41275204
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40736186
106Hippo signaling pathway_Homo sapiens_hsa043900.40475537
107Rap1 signaling pathway_Homo sapiens_hsa040150.40352420
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40105005
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39772683
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.39745370
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.39424660
112Oocyte meiosis_Homo sapiens_hsa041140.39390834
113Ovarian steroidogenesis_Homo sapiens_hsa049130.38397310
114Fatty acid biosynthesis_Homo sapiens_hsa000610.37308077
115Inositol phosphate metabolism_Homo sapiens_hsa005620.36769083
116Melanoma_Homo sapiens_hsa052180.36385592
117* Fatty acid elongation_Homo sapiens_hsa000620.36370192
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35563536
119Phagosome_Homo sapiens_hsa041450.35448657
120Type II diabetes mellitus_Homo sapiens_hsa049300.35020944
121p53 signaling pathway_Homo sapiens_hsa041150.34513510
122Phenylalanine metabolism_Homo sapiens_hsa003600.34277639
123Glucagon signaling pathway_Homo sapiens_hsa049220.34096394
124Endocytosis_Homo sapiens_hsa041440.33665794
125Retinol metabolism_Homo sapiens_hsa008300.33530704
126Parkinsons disease_Homo sapiens_hsa050120.31453093
127Endometrial cancer_Homo sapiens_hsa052130.31242160
128Steroid biosynthesis_Homo sapiens_hsa001000.30106418

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