ELMSAN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gamma-delta T cell differentiation (GO:0045586)6.01636453
2regulation of gamma-delta T cell activation (GO:0046643)5.50616762
3positive thymic T cell selection (GO:0045059)5.48538158
4endothelial cell chemotaxis (GO:0035767)5.45573236
5positive regulation of gamma-delta T cell activation (GO:0046645)4.90779755
6protein K11-linked deubiquitination (GO:0035871)4.76205569
7thymic T cell selection (GO:0045061)4.48132709
8positive T cell selection (GO:0043368)4.30707513
9L-fucose catabolic process (GO:0042355)4.27554488
10fucose catabolic process (GO:0019317)4.27554488
11L-fucose metabolic process (GO:0042354)4.27554488
12regulation of interleukin-12 biosynthetic process (GO:0045075)4.24878443
13response to pheromone (GO:0019236)4.20734237
14lactate metabolic process (GO:0006089)4.19696323
15antigen processing and presentation of endogenous antigen (GO:0019883)4.01848546
16negative thymic T cell selection (GO:0045060)3.93860782
17positive regulation of histone deacetylation (GO:0031065)3.92393609
18T cell selection (GO:0045058)3.86376802
19negative T cell selection (GO:0043383)3.83438456
20keratinocyte development (GO:0003334)3.77796687
21negative regulation of cell killing (GO:0031342)3.76021223
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.76021223
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66781286
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66781286
25cell migration involved in sprouting angiogenesis (GO:0002042)3.59419270
26DNA deamination (GO:0045006)3.52283729
27histone H3-K4 trimethylation (GO:0080182)3.49927757
28NIK/NF-kappaB signaling (GO:0038061)3.48149241
29tolerance induction (GO:0002507)3.47213854
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40285012
31JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.38516372
32regulation of B cell receptor signaling pathway (GO:0050855)3.30083438
33regulation of B cell apoptotic process (GO:0002902)3.29784885
34regulation of T cell tolerance induction (GO:0002664)3.27471387
35negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.21288863
36interferon-gamma production (GO:0032609)3.17696249
37response to laminar fluid shear stress (GO:0034616)3.17237659
38regulation of germinal center formation (GO:0002634)3.12885744
39dentate gyrus development (GO:0021542)3.11950102
40response to interleukin-15 (GO:0070672)3.06618030
41endoderm formation (GO:0001706)3.05711216
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05216402
43pre-miRNA processing (GO:0031054)3.04539060
44negative regulation of translation, ncRNA-mediated (GO:0040033)3.01912122
45regulation of translation, ncRNA-mediated (GO:0045974)3.01912122
46negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.01912122
47B cell receptor signaling pathway (GO:0050853)2.96437490
48negative regulation of execution phase of apoptosis (GO:1900118)2.94351535
49protein K6-linked ubiquitination (GO:0085020)2.94130649
50proline transport (GO:0015824)2.91899426
51positive regulation of defense response to virus by host (GO:0002230)2.90733050
52cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.89757797
53regulation of B cell differentiation (GO:0045577)2.89446630
54blood vessel endothelial cell migration (GO:0043534)2.88483880
55response to muramyl dipeptide (GO:0032495)2.87223665
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86568400
57negative regulation of erythrocyte differentiation (GO:0045647)2.85023552
58positive regulation of tolerance induction (GO:0002645)2.83085985
59prostate gland growth (GO:0060736)2.83035137
60positive regulation of protein deacetylation (GO:0090312)2.82772546
61regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.82585176
62negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82300742
63negative regulation of T-helper cell differentiation (GO:0045623)2.82300742
64negative regulation of alpha-beta T cell differentiation (GO:0046639)2.81795986
65indolalkylamine metabolic process (GO:0006586)2.80798609
66cytoplasmic mRNA processing body assembly (GO:0033962)2.80624073
67neural tube formation (GO:0001841)2.80497927
68negative regulation of granulocyte differentiation (GO:0030853)2.79488639
69detection of light stimulus involved in visual perception (GO:0050908)2.79143418
70detection of light stimulus involved in sensory perception (GO:0050962)2.79143418
71positive regulation of B cell differentiation (GO:0045579)2.79082523
72fibroblast migration (GO:0010761)2.78952149
73negative regulation of transcription regulatory region DNA binding (GO:2000678)2.78810845
74negative regulation of cAMP-mediated signaling (GO:0043951)2.78269493
75axoneme assembly (GO:0035082)2.78099383
76positive regulation of granulocyte differentiation (GO:0030854)2.72620577
77CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.72013124
78embryonic process involved in female pregnancy (GO:0060136)2.70410806
79adaptation of signaling pathway (GO:0023058)2.69914272
80regulation of DNA endoreduplication (GO:0032875)2.67507834
81positive regulation of interleukin-2 production (GO:0032743)2.67247452
82embryonic epithelial tube formation (GO:0001838)2.66656483
83natural killer cell differentiation (GO:0001779)2.66548122
84platelet dense granule organization (GO:0060155)2.62528537
85protein polyglutamylation (GO:0018095)2.61820186
86trophectodermal cell differentiation (GO:0001829)2.61159979
87nuclear pore complex assembly (GO:0051292)2.60459019
88leukocyte aggregation (GO:0070486)2.60255331
89positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.59947315
90positive regulation of mRNA metabolic process (GO:1903313)2.59481369
91positive regulation of T cell differentiation in thymus (GO:0033089)2.59078007
92negative regulation of stress fiber assembly (GO:0051497)2.58141424
93positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.56924092
94regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.56924092
95T cell receptor signaling pathway (GO:0050852)2.56701941
96cellular response to exogenous dsRNA (GO:0071360)2.56421112
97protein localization to endosome (GO:0036010)2.55307576
98positive regulation of mRNA catabolic process (GO:0061014)2.54040007
99antigen receptor-mediated signaling pathway (GO:0050851)2.53577256
100piRNA metabolic process (GO:0034587)2.53296689
101RNA destabilization (GO:0050779)2.51628556
102NLS-bearing protein import into nucleus (GO:0006607)2.50376679
103behavioral response to nicotine (GO:0035095)2.50347612
104regulation of tolerance induction (GO:0002643)2.49967476
105regulation of RNA export from nucleus (GO:0046831)2.49819097
106transepithelial transport (GO:0070633)2.49201667
107peptidyl-lysine trimethylation (GO:0018023)2.48399840
108kidney morphogenesis (GO:0060993)2.46153556
109interkinetic nuclear migration (GO:0022027)2.45509088
110regulation of interferon-beta biosynthetic process (GO:0045357)2.44810748
111regulation of interferon-alpha production (GO:0032647)2.44725009
112T cell costimulation (GO:0031295)2.43816719
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43799758
114regulation of mRNA 3-end processing (GO:0031440)2.42929222
115negative regulation of toll-like receptor signaling pathway (GO:0034122)2.42583169
116negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42143023
117regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.41800095
118regulation of mRNA catabolic process (GO:0061013)2.41357880
119negative regulation of histone methylation (GO:0031061)2.40841858
120positive regulation of glomerulus development (GO:0090193)2.40112904
121regulation of p38MAPK cascade (GO:1900744)2.40080934
122cellular response to interleukin-15 (GO:0071350)2.39644225
123positive regulation of mRNA 3-end processing (GO:0031442)2.39233182
124tryptophan catabolic process (GO:0006569)2.38913390
125indole-containing compound catabolic process (GO:0042436)2.38913390
126indolalkylamine catabolic process (GO:0046218)2.38913390
127regulation of alkaline phosphatase activity (GO:0010692)2.38831080
128positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.38764770
129regulation of neurotransmitter uptake (GO:0051580)2.38468104
130apoptotic process involved in morphogenesis (GO:0060561)2.37749814
131positive regulation of interferon-alpha production (GO:0032727)2.37484486
132regulation of T cell receptor signaling pathway (GO:0050856)2.36583793
133lymphocyte costimulation (GO:0031294)2.36571833
134positive regulation of mRNA processing (GO:0050685)2.36483882
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.36160399
136parental behavior (GO:0060746)2.35836505
137positive regulation of glycoprotein biosynthetic process (GO:0010560)2.35776918
138negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.35080634
139positive regulation of organelle assembly (GO:1902117)2.34800831
140white fat cell differentiation (GO:0050872)2.34524316
141regulation of acrosome reaction (GO:0060046)2.33863516
142negative regulation of alpha-beta T cell activation (GO:0046636)2.33279511
143establishment of endothelial barrier (GO:0061028)2.33265432
144epithelial tube formation (GO:0072175)2.32799490
145negative regulation of JUN kinase activity (GO:0043508)2.32287430
146preassembly of GPI anchor in ER membrane (GO:0016254)2.31239821
147hepatocyte apoptotic process (GO:0097284)2.31160675
148negative regulation of B cell proliferation (GO:0030889)2.30926888
149leukocyte cell-cell adhesion (GO:0007159)2.30585295
150double-strand break repair via homologous recombination (GO:0000724)2.29735013
151myeloid dendritic cell differentiation (GO:0043011)2.29629176
152mRNA stabilization (GO:0048255)2.29553616
153RNA stabilization (GO:0043489)2.29553616
154recombinational repair (GO:0000725)2.29344333
155embryonic hemopoiesis (GO:0035162)2.28591304
156negative regulation of bone resorption (GO:0045779)2.28551269
157positive regulation of p38MAPK cascade (GO:1900745)2.27818850
158growth hormone receptor signaling pathway (GO:0060396)2.27705687
159regulation of thymocyte apoptotic process (GO:0070243)2.27214376
160regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.26979223
161positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.26979223
162histone H3-K36 demethylation (GO:0070544)2.26783252
163cytochrome complex assembly (GO:0017004)2.26534969
164cell wall macromolecule catabolic process (GO:0016998)2.26523758
165regulation of telomere maintenance (GO:0032204)2.26007116
166establishment of protein localization to Golgi (GO:0072600)2.25085682
167regulation of memory T cell differentiation (GO:0043380)2.24961118
168regulation of nucleobase-containing compound transport (GO:0032239)2.24046656
169cytidine deamination (GO:0009972)2.24001862
170cytidine metabolic process (GO:0046087)2.24001862
171cytidine catabolic process (GO:0006216)2.24001862
172regulation of integrin activation (GO:0033623)2.21342574
173lymphocyte homeostasis (GO:0002260)2.21280578
174activation of JUN kinase activity (GO:0007257)2.21004185
175regulation of type I interferon-mediated signaling pathway (GO:0060338)2.20621383
176germ cell migration (GO:0008354)2.20235574
177regulation of histone deacetylation (GO:0031063)2.19632074
178regulation of alpha-beta T cell proliferation (GO:0046640)2.18382033
179mature B cell differentiation (GO:0002335)2.18257403
180cortical actin cytoskeleton organization (GO:0030866)2.17755028
181megakaryocyte development (GO:0035855)2.17503714
182myeloid dendritic cell activation (GO:0001773)2.17223793
183germinal center formation (GO:0002467)2.17220879
184response to fluid shear stress (GO:0034405)2.15592666
185regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.15565650
186positive regulation of isotype switching (GO:0045830)2.15276117
187nuclear pore organization (GO:0006999)2.15219878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.51402194
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.38584644
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.32213281
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.06157362
5MYC_22102868_ChIP-Seq_BL_Human3.91049979
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.85960804
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.82860198
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.92411299
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85149200
10ZNF274_21170338_ChIP-Seq_K562_Hela2.83244356
11TCF7_22412390_ChIP-Seq_EML_Mouse2.73792902
12VDR_21846776_ChIP-Seq_THP-1_Human2.72598007
13E2F7_22180533_ChIP-Seq_HELA_Human2.54356865
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.50679192
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.47769919
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46095393
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.43918460
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42458411
19KDM2B_26808549_Chip-Seq_DND41_Human2.41323868
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38631240
21MAF_26560356_Chip-Seq_TH1_Human2.34954763
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.32403139
23RUNX_20019798_ChIP-Seq_JUKART_Human2.23904460
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22327490
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.21249713
26VDR_22108803_ChIP-Seq_LS180_Human2.21026761
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13984960
28STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12238253
29UTX_26944678_Chip-Seq_JUKART_Human2.10275698
30ELK3_25401928_ChIP-Seq_HUVEC_Human2.08268380
31SMAD_19615063_ChIP-ChIP_OVARY_Human2.07090197
32MYB_26560356_Chip-Seq_TH2_Human2.06916016
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06826446
34GBX2_23144817_ChIP-Seq_PC3_Human2.06162044
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97214411
36ER_23166858_ChIP-Seq_MCF-7_Human1.95488217
37MYB_26560356_Chip-Seq_TH1_Human1.95151708
38SCL_19346495_ChIP-Seq_HPC-7_Human1.93012749
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92865435
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90492340
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.87819126
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86902780
43VDR_24763502_ChIP-Seq_THP-1_Human1.86127139
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85494086
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.85374105
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84300900
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81907699
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80960289
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.77605161
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76233083
51AHR_22903824_ChIP-Seq_MCF-7_Human1.72826520
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.71605425
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.66862056
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65338030
55P300_19829295_ChIP-Seq_ESCs_Human1.65266897
56BCAT_22108803_ChIP-Seq_LS180_Human1.65129178
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.61912566
58CLOCK_20551151_ChIP-Seq_293T_Human1.61505015
59FUS_26573619_Chip-Seq_HEK293_Human1.57568476
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56584986
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54723785
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54627870
63EWS_26573619_Chip-Seq_HEK293_Human1.54313234
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48581326
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47712549
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47123132
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47079740
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46604934
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.46287008
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46008760
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45609729
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.45585880
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45231980
74STAT3_23295773_ChIP-Seq_U87_Human1.45116744
75SPI1_23127762_ChIP-Seq_K562_Human1.43427697
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42499783
77CBP_20019798_ChIP-Seq_JUKART_Human1.42499783
78MAF_26560356_Chip-Seq_TH2_Human1.42062018
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41326979
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40772150
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.40081588
82NCOR1_26117541_ChIP-Seq_K562_Human1.39669912
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39075627
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39005502
85SMRT_27268052_Chip-Seq_Bcells_Human1.38352361
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37270744
87AR_25329375_ChIP-Seq_VCAP_Human1.37194030
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37061771
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.37027405
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36479191
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35885047
92TCF4_23295773_ChIP-Seq_U87_Human1.34039924
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33616683
94GATA3_26560356_Chip-Seq_TH2_Human1.33543939
95RACK7_27058665_Chip-Seq_MCF-7_Human1.32768585
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.32682377
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32622475
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32617541
99SMAD4_21799915_ChIP-Seq_A2780_Human1.31660857
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30966947
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30876153
102TAF15_26573619_Chip-Seq_HEK293_Human1.30849781
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.30761594
104CDX2_22108803_ChIP-Seq_LS180_Human1.30082564
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28767419
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28338356
107TCF4_22108803_ChIP-Seq_LS180_Human1.23051063
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22104833
109ATF3_27146783_Chip-Seq_COLON_Human1.22094111
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.22058217
111ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21950274
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21879444
113KDM2B_26808549_Chip-Seq_K562_Human1.21864278
114FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20930988
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.20868311
116GATA3_27048872_Chip-Seq_THYMUS_Human1.20378350
117LXR_22292898_ChIP-Seq_THP-1_Human1.20318257
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19405323
119VDR_24787735_ChIP-Seq_THP-1_Human1.19366908
120GATA1_19941826_ChIP-Seq_K562_Human1.19229000
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18202563
122P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18049457
123RUNX1_27514584_Chip-Seq_MCF-7_Human1.17949460
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17718732
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17563961
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.17394156
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16267025
128CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15735453
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.15582490
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15208290
131TP53_16413492_ChIP-PET_HCT116_Human1.14752787
132IRF1_19129219_ChIP-ChIP_H3396_Human1.14272468
133SOX2_19829295_ChIP-Seq_ESCs_Human1.14121522
134NANOG_19829295_ChIP-Seq_ESCs_Human1.14121522
135IGF1R_20145208_ChIP-Seq_DFB_Human1.11547515
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.09877707
137ESR2_21235772_ChIP-Seq_MCF-7_Human1.09387497
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08635363
139HOXB7_26014856_ChIP-Seq_BT474_Human1.08272942
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08191141
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08146921
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07732298
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07172656
144OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06626275
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06217845
146SMAD3_21741376_ChIP-Seq_EPCs_Human1.06144293
147SPI1_23547873_ChIP-Seq_NB4_Human1.05765177
148NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03861346
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03540936
150FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03113530
151WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02769989
152HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02655878
153SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02182576
154AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01727744
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00462316
156P53_22387025_ChIP-Seq_ESCs_Mouse1.00363438
157FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99461730
158FOXA1_25329375_ChIP-Seq_VCAP_Human0.99461730
159RUNX2_22187159_ChIP-Seq_PCA_Human0.98367158
160MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98337227
161VDR_23849224_ChIP-Seq_CD4+_Human0.98121891
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97820366
163PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97760870
164UBF1/2_26484160_Chip-Seq_HMECs_Human0.97678411
165TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97511702
166EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96144456
167NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96098545
168CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96076069
169SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96038154
170SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96038154
171PU_27001747_Chip-Seq_BMDM_Mouse0.93843082
172CIITA_25753668_ChIP-Seq_RAJI_Human0.92595444
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.91648875
174GATA6_25053715_ChIP-Seq_YYC3_Human0.91263992
175GATA2_19941826_ChIP-Seq_K562_Human0.91149894
176KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90220312
177KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90220312
178KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90220312
179ESR1_21235772_ChIP-Seq_MCF-7_Human0.90135863
180SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89593568
181EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88534119
182ZNF263_19887448_ChIP-Seq_K562_Human0.88115020
183ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87616788
184SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87183416
185TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86858240
186SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86699684
187GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85519413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.20509376
2MP0003646_muscle_fatigue3.06834941
3MP0003300_gastrointestinal_ulcer3.02525148
4MP0010352_gastrointestinal_tract_polyps2.91220339
5MP0008995_early_reproductive_senescence2.86920110
6MP0003763_abnormal_thymus_physiology2.83050891
7MP0000685_abnormal_immune_system2.77464214
8MP0003303_peritoneal_inflammation2.73088085
9MP0008877_abnormal_DNA_methylation2.59530961
10MP0003705_abnormal_hypodermis_morpholog2.56680745
11MP0004510_myositis2.54851767
12MP0005076_abnormal_cell_differentiation2.54175487
13MP0003195_calcinosis2.50796891
14MP0001790_abnormal_immune_system2.46717011
15MP0005387_immune_system_phenotype2.46717011
16MP0002163_abnormal_gland_morphology2.41094433
17MP0001800_abnormal_humoral_immune2.40241646
18MP0000427_abnormal_hair_cycle2.37801302
19MP0003786_premature_aging2.30705406
20MP0005379_endocrine/exocrine_gland_phen2.27684310
21MP0002166_altered_tumor_susceptibility2.20795289
22MP0005646_abnormal_pituitary_gland2.19047769
23MP0001835_abnormal_antigen_presentation2.18880389
24MP0003787_abnormal_imprinting2.17186113
25MP0009278_abnormal_bone_marrow2.13837253
26MP0004947_skin_inflammation2.10943628
27MP0000372_irregular_coat_pigmentation2.02980080
28MP0003566_abnormal_cell_adhesion2.00912023
29MP0008961_abnormal_basal_metabolism1.99307986
30MP0004381_abnormal_hair_follicle1.98739021
31MP0002452_abnormal_antigen_presenting1.96889339
32MP0004808_abnormal_hematopoietic_stem1.96153311
33MP0003436_decreased_susceptibility_to1.94575171
34MP0005000_abnormal_immune_tolerance1.88360020
35MP0002398_abnormal_bone_marrow1.86217660
36MP0002405_respiratory_system_inflammati1.85500617
37MP0002723_abnormal_immune_serum1.81145369
38MP0008872_abnormal_physiological_respon1.78855642
39MP0002396_abnormal_hematopoietic_system1.78707832
40MP0002420_abnormal_adaptive_immunity1.77912326
41MP0001819_abnormal_immune_cell1.75254306
42MP0002102_abnormal_ear_morphology1.71007698
43MP0003950_abnormal_plasma_membrane1.66759586
44MP0006072_abnormal_retinal_apoptosis1.66389494
45MP0005671_abnormal_response_to1.65980680
46MP0000703_abnormal_thymus_morphology1.65360737
47MP0000613_abnormal_salivary_gland1.64268264
48MP0005075_abnormal_melanosome_morpholog1.64101982
49MP0002928_abnormal_bile_duct1.64101869
50MP0005551_abnormal_eye_electrophysiolog1.63008875
51MP0001873_stomach_inflammation1.61869276
52MP0010234_abnormal_vibrissa_follicle1.61771415
53MP0002006_tumorigenesis1.61157521
54MP0000716_abnormal_immune_system1.58464030
55MP0001853_heart_inflammation1.56104889
56MP0002722_abnormal_immune_system1.54142261
57MP0010155_abnormal_intestine_physiology1.53959509
58MP0005023_abnormal_wound_healing1.53758891
59MP0002876_abnormal_thyroid_physiology1.53507605
60MP0000689_abnormal_spleen_morphology1.52467225
61MP0003453_abnormal_keratinocyte_physiol1.49829182
62MP0005645_abnormal_hypothalamus_physiol1.46529003
63MP0003045_fibrosis1.45588287
64MP0001919_abnormal_reproductive_system1.45232505
65MP0001501_abnormal_sleep_pattern1.42980947
66MP0002877_abnormal_melanocyte_morpholog1.42160143
67MP0005389_reproductive_system_phenotype1.42070185
68MP0003091_abnormal_cell_migration1.40101563
69MP0010307_abnormal_tumor_latency1.36750775
70MP0000569_abnormal_digit_pigmentation1.35813941
71MP0002254_reproductive_system_inflammat1.35474607
72MP0005397_hematopoietic_system_phenotyp1.34569930
73MP0001545_abnormal_hematopoietic_system1.34569930
74MP0002429_abnormal_blood_cell1.32705730
75MP0003866_abnormal_defecation1.32455193
76MP0000733_abnormal_muscle_development1.31923255
77MP0002160_abnormal_reproductive_system1.30359406
78MP0001851_eye_inflammation1.29370321
79MP0004185_abnormal_adipocyte_glucose1.28206300
80MP0002419_abnormal_innate_immunity1.27754424
81MP0005025_abnormal_response_to1.27232982
82MP0005367_renal/urinary_system_phenotyp1.26898338
83MP0000516_abnormal_urinary_system1.26898338
84MP0002693_abnormal_pancreas_physiology1.19985642
85MP0005464_abnormal_platelet_physiology1.16925248
86MP0008057_abnormal_DNA_replication1.16554663
87MP0000465_gastrointestinal_hemorrhage1.16206390
88MP0002168_other_aberrant_phenotype1.15716038
89MP0002009_preneoplasia1.14686386
90MP0009333_abnormal_splenocyte_physiolog1.13833268
91MP0005220_abnormal_exocrine_pancreas1.11252518
92MP0002060_abnormal_skin_morphology1.11193351
93MP0001944_abnormal_pancreas_morphology1.11186052
94MP0000631_abnormal_neuroendocrine_gland1.10814670
95MP0001845_abnormal_inflammatory_respons1.09666613
96MP0005310_abnormal_salivary_gland1.09617644
97MP0003448_altered_tumor_morphology1.09574229
98MP0003828_pulmonary_edema1.09571767
99MP0000015_abnormal_ear_pigmentation1.08507470
100MP0002933_joint_inflammation1.08052042
101MP0005253_abnormal_eye_physiology1.07603963
102MP0008775_abnormal_heart_ventricle1.06884421
103MP0004043_abnormal_pH_regulation1.06062068
104MP0001986_abnormal_taste_sensitivity1.04901939
105MP0003279_aneurysm1.02872404
106MP0006292_abnormal_olfactory_placode1.00823868
107MP0005275_abnormal_skin_tensile0.98947536
108MP0000490_abnormal_crypts_of0.98379530
109MP0002138_abnormal_hepatobiliary_system0.98265361
110MP0005174_abnormal_tail_pigmentation0.97762134
111MP0004142_abnormal_muscle_tone0.97183454
112MP0002998_abnormal_bone_remodeling0.96456496
113MP0008058_abnormal_DNA_repair0.95794761
114MP0000858_altered_metastatic_potential0.95384893
115MP0001216_abnormal_epidermal_layer0.94550866
116MP0001533_abnormal_skeleton_physiology0.94462639
117MP0001502_abnormal_circadian_rhythm0.93946264
118MP0001243_abnormal_dermal_layer0.93095748
119MP0001485_abnormal_pinna_reflex0.92526102
120MP0000538_abnormal_urinary_bladder0.91032287
121MP0006082_CNS_inflammation0.90875155
122MP0009780_abnormal_chondrocyte_physiolo0.90747616
123MP0010630_abnormal_cardiac_muscle0.89524394
124MP0002925_abnormal_cardiovascular_devel0.88167910
125MP0005647_abnormal_sex_gland0.87727829
126MP0006054_spinal_hemorrhage0.86698930
127MP0002086_abnormal_extraembryonic_tissu0.86078679
128MP0002148_abnormal_hypersensitivity_rea0.85810992
129MP0002088_abnormal_embryonic_growth/wei0.84876752
130MP0009115_abnormal_fat_cell0.84085329
131MP0000350_abnormal_cell_proliferation0.83163529
132MP0003984_embryonic_growth_retardation0.82261848
133MP0003943_abnormal_hepatobiliary_system0.82234884
134MP0002019_abnormal_tumor_incidence0.80502546
135MP0008438_abnormal_cutaneous_collagen0.80177791
136MP0002796_impaired_skin_barrier0.79952438
137MP0000230_abnormal_systemic_arterial0.79063721
138MP0001727_abnormal_embryo_implantation0.78104547
139MP0008875_abnormal_xenobiotic_pharmacok0.77487907
140MP0003252_abnormal_bile_duct0.77288360
141MP0004197_abnormal_fetal_growth/weight/0.76963182
142MP0000767_abnormal_smooth_muscle0.76883100
143MP0010678_abnormal_skin_adnexa0.76278844
144MP0002282_abnormal_trachea_morphology0.76188707
145MP0004264_abnormal_extraembryonic_tissu0.74321959
146MP0003077_abnormal_cell_cycle0.74094439
147MP0001348_abnormal_lacrimal_gland0.73844855
148MP0000383_abnormal_hair_follicle0.73633197
149MP0005375_adipose_tissue_phenotype0.72931982
150MP0009931_abnormal_skin_appearance0.72126325
151MP0001765_abnormal_ion_homeostasis0.72031257
152MP0005390_skeleton_phenotype0.70045460
153MP0001672_abnormal_embryogenesis/_devel0.69805319
154MP0005380_embryogenesis_phenotype0.69805319
155MP0005621_abnormal_cell_physiology0.69011758
156MP0009785_altered_susceptibility_to0.68839197
157MP0009046_muscle_twitch0.66732767
158MP0005395_other_phenotype0.66187355
159MP0002136_abnormal_kidney_physiology0.63090423
160MP0000647_abnormal_sebaceous_gland0.62834984
161MP0000653_abnormal_sex_gland0.61212831
162MP0001119_abnormal_female_reproductive0.60148548
163MP0003011_delayed_dark_adaptation0.59800603

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.61283975
2Abnormality of midbrain morphology (HP:0002418)3.57217616
3Molar tooth sign on MRI (HP:0002419)3.57217616
4Abnormality of the fingertips (HP:0001211)3.56599230
5Pancreatic cysts (HP:0001737)3.40307070
6Congenital stationary night blindness (HP:0007642)3.18554399
7Genetic anticipation (HP:0003743)3.14802202
8Nephronophthisis (HP:0000090)3.08654311
9Chronic hepatic failure (HP:0100626)3.06690120
10True hermaphroditism (HP:0010459)3.01729452
11Increased density of long bones (HP:0006392)3.00722069
12Abnormality of the renal cortex (HP:0011035)2.99693466
13Stomach cancer (HP:0012126)2.95096044
14Colitis (HP:0002583)2.88307593
15Gaze-evoked nystagmus (HP:0000640)2.87140532
16Hematochezia (HP:0002573)2.81487807
17Abnormality of the renal medulla (HP:0100957)2.81130378
18Hyperventilation (HP:0002883)2.77868871
19Abnormal pancreas size (HP:0012094)2.77426014
20Recurrent viral infections (HP:0004429)2.77151886
21Stomatitis (HP:0010280)2.77150480
22Tubular atrophy (HP:0000092)2.76442606
23Eczematoid dermatitis (HP:0000976)2.75965287
24Increased IgE level (HP:0003212)2.75522643
25Hypothermia (HP:0002045)2.73980469
26Aortic aneurysm (HP:0004942)2.72597631
27IgM deficiency (HP:0002850)2.72432994
28Large for gestational age (HP:0001520)2.70640463
29Recurrent fungal infections (HP:0002841)2.70240791
30Cellulitis (HP:0100658)2.68637388
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.64786519
32Inflammation of the large intestine (HP:0002037)2.63355898
33Mitral valve prolapse (HP:0001634)2.62362302
34Neoplasm of the adrenal cortex (HP:0100641)2.61150651
35Pancreatic fibrosis (HP:0100732)2.61124328
36Gastrointestinal inflammation (HP:0004386)2.58496270
37Hypoplastic iliac wings (HP:0002866)2.55432391
38Type II lissencephaly (HP:0007260)2.46608826
39Neoplasm of the tracheobronchial system (HP:0100552)2.44136252
40Abnormality of the nasal septum (HP:0000419)2.43094676
41Persistence of primary teeth (HP:0006335)2.42760063
42Alveolar cell carcinoma (HP:0006519)2.42550699
43Recurrent bronchitis (HP:0002837)2.41811051
44Emphysema (HP:0002097)2.41715957
45T lymphocytopenia (HP:0005403)2.41106610
46Abnormality of the proximal phalanges of the hand (HP:0009834)2.40954998
47Attenuation of retinal blood vessels (HP:0007843)2.38051922
48Shallow orbits (HP:0000586)2.38023840
49Spontaneous hematomas (HP:0007420)2.36972852
50Abnormal rod and cone electroretinograms (HP:0008323)2.36139192
51Hamartoma of the eye (HP:0010568)2.34555508
52Abolished electroretinogram (ERG) (HP:0000550)2.32466313
53Panhypogammaglobulinemia (HP:0003139)2.32252090
54Albinism (HP:0001022)2.31210968
55Pendular nystagmus (HP:0012043)2.30175586
56Abnormality of T cell number (HP:0011839)2.28407097
57Ulnar bowing (HP:0003031)2.27225488
58Macroorchidism (HP:0000053)2.26909158
59Chronic otitis media (HP:0000389)2.26572645
60Agammaglobulinemia (HP:0004432)2.26494815
61Autoimmune thrombocytopenia (HP:0001973)2.26229973
62Verrucae (HP:0200043)2.26128085
63Papilloma (HP:0012740)2.26128085
64Abnormality of the phalanges of the 2nd finger (HP:0009541)2.25603813
65Nasal polyposis (HP:0100582)2.25188679
66Pustule (HP:0200039)2.24805148
67Elevated erythrocyte sedimentation rate (HP:0003565)2.24367685
68Progressive cerebellar ataxia (HP:0002073)2.24337623
69Cerebellar dysplasia (HP:0007033)2.24232316
70Abnormal drinking behavior (HP:0030082)2.19947344
71Polydipsia (HP:0001959)2.19947344
72Disproportionate tall stature (HP:0001519)2.17802111
73Dilatation of the ascending aorta (HP:0005111)2.16447901
74Aplasia/Hypoplasia of the spleen (HP:0010451)2.14966736
75Gastrointestinal stroma tumor (HP:0100723)2.13735964
76Abnormality of the nasal mucosa (HP:0000433)2.12260255
77Long eyelashes (HP:0000527)2.11748926
78Osteolytic defects of the hand bones (HP:0009699)2.11324981
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.11324981
80Decreased circulating renin level (HP:0003351)2.11121592
81Ketoacidosis (HP:0001993)2.10090387
82Myocardial infarction (HP:0001658)2.09283038
83Keratoconus (HP:0000563)2.07130904
84Increased corneal curvature (HP:0100692)2.07130904
85Hypoplasia of the uterus (HP:0000013)2.05746504
86Tented upper lip vermilion (HP:0010804)2.05214683
87Aqueductal stenosis (HP:0002410)2.04641998
88Hyperinsulinemic hypoglycemia (HP:0000825)2.04523627
89Asplenia (HP:0001746)2.04350441
90Submucous cleft hard palate (HP:0000176)2.03429659
91Milia (HP:0001056)2.03426078
92Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03147013
93Pigmentary retinal degeneration (HP:0001146)2.02544415
94Genu recurvatum (HP:0002816)2.01926726
95Autoimmune hemolytic anemia (HP:0001890)2.01791234
96Polyuria (HP:0000103)2.00871141
97Abnormality of T cells (HP:0002843)1.99956109
98Increased connective tissue (HP:0009025)1.98979834
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98905169
100Aneurysm (HP:0002617)1.98850237
101Abnormality of the metopic suture (HP:0005556)1.98067957
102Widely spaced teeth (HP:0000687)1.97877821
103Lymphopenia (HP:0001888)1.97388091
104Fair hair (HP:0002286)1.97099256
105Abnormality of cells of the lymphoid lineage (HP:0012140)1.95324592
106Narrow palate (HP:0000189)1.95048439
107Enlarged penis (HP:0000040)1.94554880
108Short 4th metacarpal (HP:0010044)1.93622121
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93622121
110IgG deficiency (HP:0004315)1.92920043
111Protrusio acetabuli (HP:0003179)1.92850815
112Abnormality of the pons (HP:0007361)1.91868250
113Spondylolisthesis (HP:0003302)1.91447349
114Prostate neoplasm (HP:0100787)1.91391450
115Cystic liver disease (HP:0006706)1.91358688
116Medial flaring of the eyebrow (HP:0010747)1.91262888
117Bicuspid aortic valve (HP:0001647)1.91236275
118Aortic dissection (HP:0002647)1.90855187
119Lissencephaly (HP:0001339)1.90331618
120Abnormality of B cell number (HP:0010975)1.89332985
121Urethral obstruction (HP:0000796)1.89254503
122IgA deficiency (HP:0002720)1.87438782
123Volvulus (HP:0002580)1.86377879
124Periodontitis (HP:0000704)1.85877042
125Aplasia/hypoplasia of the uterus (HP:0008684)1.85423135
126Macular degeneration (HP:0000608)1.84196383
127Broad metatarsal (HP:0001783)1.83618576
128Depressed nasal tip (HP:0000437)1.83396960
129Intestinal atresia (HP:0011100)1.83349837
130Hyperglycemia (HP:0003074)1.82905929
131Pulmonary infiltrates (HP:0002113)1.82590032
132Furrowed tongue (HP:0000221)1.81611999
133Methylmalonic acidemia (HP:0002912)1.81106625
134Shawl scrotum (HP:0000049)1.80624302
135Recurrent cutaneous fungal infections (HP:0011370)1.79560735
136Chronic mucocutaneous candidiasis (HP:0002728)1.79560735
137Vasculitis (HP:0002633)1.79377819
138Abnormality of the renal collecting system (HP:0004742)1.79192648
139Chest pain (HP:0100749)1.78793740
140Myositis (HP:0100614)1.78575151
141Breast carcinoma (HP:0003002)1.78118926
142Vertebral arch anomaly (HP:0008438)1.78113498
143Recurrent abscess formation (HP:0002722)1.78053919
144Mediastinal lymphadenopathy (HP:0100721)1.78011057
145Generalized hypopigmentation of hair (HP:0011358)1.77746400
146Cone-rod dystrophy (HP:0000548)1.76721814
147Restrictive lung disease (HP:0002091)1.76488610
148Thyroiditis (HP:0100646)1.76437001
149Ketosis (HP:0001946)1.76342497
150Leukocytosis (HP:0001974)1.76117218
151Abnormal platelet volume (HP:0011876)1.75936266
152Heterotopia (HP:0002282)1.75346142
153Oligodactyly (hands) (HP:0001180)1.75178393
154Decreased central vision (HP:0007663)1.75116844
155Prominent metopic ridge (HP:0005487)1.74920075
156Lip pit (HP:0100267)1.74485112
157Arterial thrombosis (HP:0004420)1.74354747
158Short 1st metacarpal (HP:0010034)1.74342557
159Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.74342557
160Abnormality of T cell physiology (HP:0011840)1.74249175
161Skin tags (HP:0010609)1.74004356
162Absent speech (HP:0001344)1.73355178
163Abnormality of the prostate (HP:0008775)1.72982357
164Basal cell carcinoma (HP:0002671)1.72759017
165Abnormal albumin level (HP:0012116)1.72661763
166Hypoalbuminemia (HP:0003073)1.72661763
167Ectopic kidney (HP:0000086)1.72406756
168Conjunctival hamartoma (HP:0100780)1.72052870
169Combined immunodeficiency (HP:0005387)1.72021809
170Increased CSF protein (HP:0002922)1.71914102
171Dislocated radial head (HP:0003083)1.71831535
172Metabolic alkalosis (HP:0200114)1.71464106
173Striae distensae (HP:0001065)1.71360899
174Abnormality of the labia minora (HP:0012880)1.71204199
175Eosinophilia (HP:0001880)1.71196745
176Prominent nose (HP:0000448)1.70773133
177Hyperacusis (HP:0010780)1.70696251
178Prolonged bleeding time (HP:0003010)1.69862674
179Interstitial pulmonary disease (HP:0006530)1.69818231
180Abnormality of DNA repair (HP:0003254)1.69763627
181Neoplasm of the lung (HP:0100526)1.68018549
182Somatic mutation (HP:0001428)1.67886029
183Curly hair (HP:0002212)1.67844532
184Ureteral stenosis (HP:0000071)1.66901164
185Polycythemia (HP:0001901)1.66119136
186Mitral regurgitation (HP:0001653)1.65487549
187Gingivitis (HP:0000230)1.64539274
188Spinal cord lesions (HP:0100561)1.64523835
189Syringomyelia (HP:0003396)1.64523835
190Sparse lateral eyebrow (HP:0005338)1.64401826
191Rectal prolapse (HP:0002035)1.62309417
192Frequent falls (HP:0002359)1.61686397
193Ureteral obstruction (HP:0006000)1.60985842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.49023885
2MAP4K14.29262276
3CDK123.53118732
4EIF2AK33.35373727
5MAP3K103.19956694
6EEF2K2.85282004
7STK102.72340762
8AKT32.52813597
9NUAK12.47121597
10ERN12.45605355
11TRIB32.37083409
12GRK12.36558319
13TNIK2.07545042
14STK392.04981944
15GRK62.02243953
16MKNK21.99635375
17TGFBR21.94176998
18BRSK21.88987580
19BMPR1B1.81703689
20EPHB11.80400285
21ITK1.80031938
22OXSR11.75388654
23SIK31.73804271
24RIPK11.71470996
25TTN1.69466183
26PKN21.67491394
27TYK21.64367667
28FGFR41.62159514
29MAPKAPK31.56184470
30JAK31.54248431
31LRRK21.50268057
32FER1.49575728
33SGK21.49302442
34PAK31.48946329
35MAP3K141.48786112
36PTK61.48720975
37SIK11.48247007
38ZAP701.46730938
39CHUK1.41573178
40JAK11.40020242
41EPHA31.39702823
42FGFR31.38921994
43CAMK1D1.35641392
44RPS6KA41.34569492
45WNK31.33275177
46TRIM281.30378356
47DMPK1.29413490
48IKBKB1.28592822
49BRD41.26489539
50MAP4K21.26299110
51WEE11.26003320
52PIM11.23913307
53TXK1.23788638
54CSF1R1.21249653
55HCK1.20081564
56BMPR21.19093148
57ADRBK21.18658283
58INSRR1.18417582
59MAP2K31.16839723
60CAMK1G1.15678759
61CSK1.13789327
62TBK11.13336282
63BTK1.11717070
64PLK21.10874145
65EIF2AK11.08349047
66MAPK131.07036780
67MTOR1.06388194
68SIK21.05299009
69BMX1.01205026
70NLK1.00874527
71CDK60.99801952
72MAP3K130.99619138
73IKBKE0.97878329
74TAOK10.95526223
75TNK20.95502016
76MARK30.94002827
77ALK0.93745765
78MAP3K70.93234367
79PDGFRB0.92900272
80SGK30.90695553
81PRKCI0.90685966
82LCK0.90532302
83ERBB30.89609928
84PIK3CA0.89367522
85HIPK20.88992883
86MELK0.84268893
87ICK0.84173324
88CDK40.81971710
89MAP3K30.81674647
90PRKCE0.80102445
91MST40.79315082
92CDK90.78673963
93PRKCQ0.77952661
94RPS6KB20.77606074
95PDGFRA0.77453525
96TAOK30.75788935
97RPS6KA50.75548905
98IRAK10.75090626
99SYK0.75041157
100JAK20.74274784
101RIPK40.73469871
102PINK10.71949629
103PTK2B0.71802215
104MAP3K80.71742402
105EIF2AK20.70728357
106BLK0.70684958
107FLT30.68594861
108PRKD20.67394068
109RPS6KA10.65768971
110PRKCH0.65242791
111PAK20.64012015
112PNCK0.64001779
113IRAK40.62822177
114PTK20.62570863
115CLK10.61931275
116TEC0.61134073
117SGK2230.59169207
118SGK4940.59169207
119SCYL20.58362167
120MUSK0.58282470
121FGFR10.57733071
122ACVR1B0.56969749
123NEK20.56912296
124KIT0.55042232
125STK40.54562753
126FGFR20.53112040
127DYRK1B0.52270247
128MAPKAPK20.51823362
129MARK20.51235120
130PIK3CG0.51232020
131IRAK30.50790336
132ABL10.49334444
133ZAK0.49030668
134STK160.48547753
135STK30.48451614
136LATS10.47880257
137PAK40.47302403
138CSNK1G10.46380207
139MAPK70.46105266
140GSK3A0.45410077
141STK110.44854945
142MAPK150.43137713
143CCNB10.42772858
144RPS6KA60.42472219
145PRKD10.42231257
146MAP3K110.42126124
147TRPM70.41911266
148MAPK10.41009390
149INSR0.40380424
150EGFR0.39225691
151CSNK1A1L0.38077643
152ADRBK10.37784336
153TAF10.37259272
154MKNK10.35361547
155MAPK110.34412946
156PRKAA20.33968275
157CSNK1G20.33835631
158DAPK20.33635420
159PRKAA10.33228499
160LYN0.32218004
161CSNK1D0.30635799
162YES10.30383870
163CSNK1G30.30339178
164STK38L0.30298057
165PRKCZ0.29696619

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.64183810
2B cell receptor signaling pathway_Homo sapiens_hsa046622.57063747
3Asthma_Homo sapiens_hsa053102.37454165
4Type I diabetes mellitus_Homo sapiens_hsa049402.37357596
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34492427
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.31666621
7Osteoclast differentiation_Homo sapiens_hsa043802.30197753
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28708319
9Autoimmune thyroid disease_Homo sapiens_hsa053202.13448713
10Graft-versus-host disease_Homo sapiens_hsa053322.13352498
11T cell receptor signaling pathway_Homo sapiens_hsa046602.12162792
12Phototransduction_Homo sapiens_hsa047442.11636026
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.09708288
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99729605
15Chronic myeloid leukemia_Homo sapiens_hsa052201.93308983
16Acute myeloid leukemia_Homo sapiens_hsa052211.81203654
17RNA degradation_Homo sapiens_hsa030181.79801721
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.78468635
19Leishmaniasis_Homo sapiens_hsa051401.76760917
20Circadian rhythm_Homo sapiens_hsa047101.72591660
21Toxoplasmosis_Homo sapiens_hsa051451.66545734
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64556274
23Protein export_Homo sapiens_hsa030601.64371764
24Antigen processing and presentation_Homo sapiens_hsa046121.61342866
25Measles_Homo sapiens_hsa051621.57408174
26Small cell lung cancer_Homo sapiens_hsa052221.52086691
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50046191
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.48154282
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.47880060
30Hepatitis B_Homo sapiens_hsa051611.46257638
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.46156290
32Selenocompound metabolism_Homo sapiens_hsa004501.40359762
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38458978
34Pancreatic cancer_Homo sapiens_hsa052121.37958280
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36815465
36Notch signaling pathway_Homo sapiens_hsa043301.36643515
37TNF signaling pathway_Homo sapiens_hsa046681.36442947
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35611553
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34018213
40Fanconi anemia pathway_Homo sapiens_hsa034601.33836009
41Viral myocarditis_Homo sapiens_hsa054161.32791097
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.32621916
43Hematopoietic cell lineage_Homo sapiens_hsa046401.32538873
44Nitrogen metabolism_Homo sapiens_hsa009101.32433378
45Butanoate metabolism_Homo sapiens_hsa006501.32386229
46MicroRNAs in cancer_Homo sapiens_hsa052061.29298521
47Apoptosis_Homo sapiens_hsa042101.29174622
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27450133
49Adherens junction_Homo sapiens_hsa045201.26546966
50HTLV-I infection_Homo sapiens_hsa051661.26236388
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25479039
52Proteoglycans in cancer_Homo sapiens_hsa052051.23533210
53mTOR signaling pathway_Homo sapiens_hsa041501.23284351
54Lysine degradation_Homo sapiens_hsa003101.22654153
55Viral carcinogenesis_Homo sapiens_hsa052031.21969436
56Regulation of autophagy_Homo sapiens_hsa041401.20419323
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.20392026
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18479124
59Herpes simplex infection_Homo sapiens_hsa051681.18362834
60Caffeine metabolism_Homo sapiens_hsa002321.17683772
61Insulin resistance_Homo sapiens_hsa049311.16198575
62Linoleic acid metabolism_Homo sapiens_hsa005911.15987486
63Platelet activation_Homo sapiens_hsa046111.14657713
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13547570
65VEGF signaling pathway_Homo sapiens_hsa043701.13103049
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13020575
67Chemokine signaling pathway_Homo sapiens_hsa040621.12984397
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12273702
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12232697
70Shigellosis_Homo sapiens_hsa051311.11532108
71Homologous recombination_Homo sapiens_hsa034401.11134638
72Non-small cell lung cancer_Homo sapiens_hsa052231.10661082
73Colorectal cancer_Homo sapiens_hsa052101.10223272
74Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06793638
75Prolactin signaling pathway_Homo sapiens_hsa049171.04434596
76Focal adhesion_Homo sapiens_hsa045101.02280705
77Basal transcription factors_Homo sapiens_hsa030221.02128052
78Influenza A_Homo sapiens_hsa051641.00447765
79Renal cell carcinoma_Homo sapiens_hsa052110.99931850
80Dorso-ventral axis formation_Homo sapiens_hsa043200.99198396
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99041397
82Tryptophan metabolism_Homo sapiens_hsa003800.98373746
83Ether lipid metabolism_Homo sapiens_hsa005650.96985260
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96013721
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.92885187
86MAPK signaling pathway_Homo sapiens_hsa040100.92467392
87RNA polymerase_Homo sapiens_hsa030200.91155554
88FoxO signaling pathway_Homo sapiens_hsa040680.89904344
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89615075
90Insulin secretion_Homo sapiens_hsa049110.89104766
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88927559
92Non-homologous end-joining_Homo sapiens_hsa034500.88727836
93Malaria_Homo sapiens_hsa051440.88656035
94Prostate cancer_Homo sapiens_hsa052150.88121196
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87309432
96Endometrial cancer_Homo sapiens_hsa052130.86897563
97Type II diabetes mellitus_Homo sapiens_hsa049300.86580103
98Tuberculosis_Homo sapiens_hsa051520.83947088
99Amoebiasis_Homo sapiens_hsa051460.83516289
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81731106
101Pathways in cancer_Homo sapiens_hsa052000.80930731
102Hepatitis C_Homo sapiens_hsa051600.79493398
103Epstein-Barr virus infection_Homo sapiens_hsa051690.78588172
104Rheumatoid arthritis_Homo sapiens_hsa053230.77720874
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76698291
106Ovarian steroidogenesis_Homo sapiens_hsa049130.76113177
107Legionellosis_Homo sapiens_hsa051340.75414286
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73550946
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73496805
110Bladder cancer_Homo sapiens_hsa052190.73307126
111p53 signaling pathway_Homo sapiens_hsa041150.72536653
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71257545
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71146715
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70871373
115Endocytosis_Homo sapiens_hsa041440.69945835
116ABC transporters_Homo sapiens_hsa020100.69695148
117HIF-1 signaling pathway_Homo sapiens_hsa040660.69240396
118ECM-receptor interaction_Homo sapiens_hsa045120.68985780
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66831502
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66293103
121Olfactory transduction_Homo sapiens_hsa047400.65844962
122Inositol phosphate metabolism_Homo sapiens_hsa005620.65658274
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.64503326
124Salmonella infection_Homo sapiens_hsa051320.64436540
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63990417
126Glioma_Homo sapiens_hsa052140.63152367
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62991280
128Insulin signaling pathway_Homo sapiens_hsa049100.61873920
129TGF-beta signaling pathway_Homo sapiens_hsa043500.61221135
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60662581
131Pertussis_Homo sapiens_hsa051330.60223864
132Rap1 signaling pathway_Homo sapiens_hsa040150.59320524
133Estrogen signaling pathway_Homo sapiens_hsa049150.59224634
134Thyroid cancer_Homo sapiens_hsa052160.58786640
135Propanoate metabolism_Homo sapiens_hsa006400.58512552
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57859434
137Staphylococcus aureus infection_Homo sapiens_hsa051500.57005488
138AMPK signaling pathway_Homo sapiens_hsa041520.56139230
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54753326
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.53647663
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.53065245
142ErbB signaling pathway_Homo sapiens_hsa040120.51849411
143Hippo signaling pathway_Homo sapiens_hsa043900.51810170
144Allograft rejection_Homo sapiens_hsa053300.51651584
145Choline metabolism in cancer_Homo sapiens_hsa052310.51551545
146Sphingolipid metabolism_Homo sapiens_hsa006000.50455003
147Glycerolipid metabolism_Homo sapiens_hsa005610.50367886
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46645025
149Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44903183
150Serotonergic synapse_Homo sapiens_hsa047260.42337191
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41291535
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.40473334
153cAMP signaling pathway_Homo sapiens_hsa040240.38492873
154Calcium signaling pathway_Homo sapiens_hsa040200.38007915
155Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37453455
156Circadian entrainment_Homo sapiens_hsa047130.35159787

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