ELK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.66601355
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.53481392
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.34014184
4synaptic vesicle maturation (GO:0016188)5.32992509
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.15178524
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.14947058
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95141257
8regulation of glutamate receptor signaling pathway (GO:1900449)4.84819486
9vocalization behavior (GO:0071625)4.83527754
10synaptic vesicle exocytosis (GO:0016079)4.64523080
11glutamate secretion (GO:0014047)4.52455754
12positive regulation of synapse maturation (GO:0090129)4.51999067
13Golgi transport vesicle coating (GO:0048200)4.49451697
14COPI coating of Golgi vesicle (GO:0048205)4.49451697
15protein localization to synapse (GO:0035418)4.45700790
16layer formation in cerebral cortex (GO:0021819)4.39506964
17negative regulation of erythrocyte differentiation (GO:0045647)4.30734132
18regulation of synaptic vesicle exocytosis (GO:2000300)4.30515500
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.22352864
20neurotransmitter-gated ion channel clustering (GO:0072578)4.16453282
21regulation of early endosome to late endosome transport (GO:2000641)4.14671378
22protein localization to endosome (GO:0036010)4.13712480
23exploration behavior (GO:0035640)4.11943660
24dendritic spine morphogenesis (GO:0060997)4.07570091
25glutamate receptor signaling pathway (GO:0007215)4.02681819
26regulation of synapse structural plasticity (GO:0051823)3.99080677
27regulation of neuronal synaptic plasticity (GO:0048168)3.96921989
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95981742
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.87700406
30activation of MAPKKK activity (GO:0000185)3.83387136
31positive regulation of dendritic spine morphogenesis (GO:0061003)3.83324009
32sodium ion export (GO:0071436)3.81173234
33synaptic transmission, glutamatergic (GO:0035249)3.80088627
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.76936704
35regulation of synaptic vesicle transport (GO:1902803)3.73662205
36cellular potassium ion homeostasis (GO:0030007)3.73075837
37regulation of dendritic spine morphogenesis (GO:0061001)3.70461412
38synaptic vesicle endocytosis (GO:0048488)3.65982263
39neurotransmitter secretion (GO:0007269)3.65967115
40regulation of NFAT protein import into nucleus (GO:0051532)3.64953099
41long-term memory (GO:0007616)3.59565160
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57671700
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55966031
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55431821
45cell communication by electrical coupling (GO:0010644)3.50869909
46regulation of mammary gland epithelial cell proliferation (GO:0033599)3.50823918
47neuromuscular process controlling balance (GO:0050885)3.50242363
48dendrite morphogenesis (GO:0048813)3.42612105
49protein retention in ER lumen (GO:0006621)3.39892187
50regulation of postsynaptic membrane potential (GO:0060078)3.38683195
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.38030890
52neuron-neuron synaptic transmission (GO:0007270)3.36988373
53neuron cell-cell adhesion (GO:0007158)3.36454117
54cerebellar Purkinje cell differentiation (GO:0021702)3.36241611
55axonal fasciculation (GO:0007413)3.35060785
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34027364
57proline transport (GO:0015824)3.33188647
58regulation of synapse maturation (GO:0090128)3.33104594
59adherens junction assembly (GO:0034333)3.33041744
60regulation of synaptic plasticity (GO:0048167)3.31666197
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31224372
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27075133
63positive regulation of membrane potential (GO:0045838)3.26662404
64cellular protein complex localization (GO:0034629)3.26485116
65modulation by symbiont of host cellular process (GO:0044068)3.24357382
66establishment of nucleus localization (GO:0040023)3.23419219
67cytoskeletal anchoring at plasma membrane (GO:0007016)3.22688577
68central nervous system projection neuron axonogenesis (GO:0021952)3.21995378
69cell migration in hindbrain (GO:0021535)3.21237584
70regulation of clathrin-mediated endocytosis (GO:2000369)3.20994916
71neuron recognition (GO:0008038)3.19606584
72focal adhesion assembly (GO:0048041)3.18726986
73cell-substrate adherens junction assembly (GO:0007045)3.18726986
74positive regulation of fibroblast migration (GO:0010763)3.17778145
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.16237891
76proline biosynthetic process (GO:0006561)3.15165134
77cerebellar granule cell differentiation (GO:0021707)3.14052624
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12619202
79innervation (GO:0060384)3.07131505
80positive regulation of dendritic spine development (GO:0060999)3.06367413
81stress fiber assembly (GO:0043149)3.05161661
82positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.03987309
83gamma-aminobutyric acid transport (GO:0015812)3.03093523
84dendritic spine organization (GO:0097061)3.02397014
85mitotic chromosome condensation (GO:0007076)3.01071790
86activation of protein kinase A activity (GO:0034199)3.00461859
87neuronal action potential propagation (GO:0019227)2.95908499
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.95328687
89regulation of neurotransmitter secretion (GO:0046928)2.95323200
90activation of Rac GTPase activity (GO:0032863)2.95074720
91postsynaptic membrane organization (GO:0001941)2.94515093
92long-term synaptic potentiation (GO:0060291)2.92990014
93regulation of glucose import in response to insulin stimulus (GO:2001273)2.91962716
94membrane depolarization during action potential (GO:0086010)2.91945074
95regulation of dendritic spine development (GO:0060998)2.91722361
96gamma-aminobutyric acid signaling pathway (GO:0007214)2.91639982
97behavioral fear response (GO:0001662)2.90794703
98behavioral defense response (GO:0002209)2.90794703
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88735919
100protein maturation by protein folding (GO:0022417)2.87949516
101negative regulation of cell size (GO:0045792)2.86678422
102barbed-end actin filament capping (GO:0051016)2.85609577
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84592884
104regulation of vitamin D biosynthetic process (GO:0060556)2.84361140
105regulation of ARF protein signal transduction (GO:0032012)2.83972821
106adhesion of symbiont to host (GO:0044406)2.80800241
107membrane depolarization (GO:0051899)2.80321376
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79586164
109response to auditory stimulus (GO:0010996)2.77579650
110auditory behavior (GO:0031223)2.77219856
111neuromuscular process (GO:0050905)2.77041804
112signal complex assembly (GO:0007172)2.75983571
113modulation by virus of host process (GO:0019054)2.75741263
1143-UTR-mediated mRNA stabilization (GO:0070935)2.73532639
115protein complex localization (GO:0031503)2.72506265
116embryonic process involved in female pregnancy (GO:0060136)2.72305688
117learning (GO:0007612)2.71813231
118neurotransmitter transport (GO:0006836)2.71277021
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.70589693
120negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.70085753
121response to laminar fluid shear stress (GO:0034616)2.69985464
122positive regulation of dendrite development (GO:1900006)2.68447147
123regulation of neurotransmitter transport (GO:0051588)2.68137816
124nuclear envelope reassembly (GO:0031468)2.67947180
125mitotic nuclear envelope reassembly (GO:0007084)2.67947180
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67779781
127prepulse inhibition (GO:0060134)2.66843619
128DNA unwinding involved in DNA replication (GO:0006268)2.66561618
129neuromuscular process controlling posture (GO:0050884)2.66307976
130transmission of nerve impulse (GO:0019226)2.65677590
131vesicle transport along microtubule (GO:0047496)2.65636143
132positive regulation of nuclease activity (GO:0032075)2.64965343
133positive regulation of protein dephosphorylation (GO:0035307)2.64550209
134L-amino acid import (GO:0043092)2.64299100
135regulation of synaptic transmission (GO:0050804)2.64131735
136pentose-phosphate shunt (GO:0006098)2.62588317
137cerebellar Purkinje cell layer development (GO:0021680)2.62298723
138positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62110255
139regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.61754017
140positive regulation of dendrite morphogenesis (GO:0050775)2.61655075
141fear response (GO:0042596)2.60859088
142regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.60718594
143positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.60718594
144response to histamine (GO:0034776)2.60154074
145positive regulation of synaptic transmission (GO:0050806)2.59862953
146low-density lipoprotein particle clearance (GO:0034383)2.59644370
147regulation of vesicle fusion (GO:0031338)2.59042921
148positive regulation of neurotransmitter secretion (GO:0001956)2.58183321
149apoptotic process involved in morphogenesis (GO:0060561)2.56681153
150NIK/NF-kappaB signaling (GO:0038061)2.55528122
151protein targeting to plasma membrane (GO:0072661)2.54347427
152cellular response to virus (GO:0098586)2.54144063
153regulation of nucleobase-containing compound transport (GO:0032239)2.51065642
154pinocytosis (GO:0006907)2.49111611
155modulation by virus of host morphology or physiology (GO:0019048)2.49073432
156amyloid precursor protein catabolic process (GO:0042987)2.48849982
157intracellular estrogen receptor signaling pathway (GO:0030520)2.48659950
158regulation of chromatin binding (GO:0035561)2.48522153
159epithelial cell-cell adhesion (GO:0090136)2.47727330
160maternal placenta development (GO:0001893)2.47678623
161spliceosomal tri-snRNP complex assembly (GO:0000244)2.47317509
162positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.46605419
163skin morphogenesis (GO:0043589)2.45747343
164cortical actin cytoskeleton organization (GO:0030866)2.44486688
165endoplasmic reticulum unfolded protein response (GO:0030968)2.44419489
166regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.43540027
167regulation of translational fidelity (GO:0006450)2.43174677
168positive regulation of blood vessel endothelial cell migration (GO:0043536)2.42819304
169mannose metabolic process (GO:0006013)2.42729062
170cell-substrate junction assembly (GO:0007044)2.42044404
171negative regulation of necrotic cell death (GO:0060547)2.41296795
172endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.41161291
173regulation of nuclease activity (GO:0032069)2.40763962
174positive regulation of Cdc42 GTPase activity (GO:0043089)2.39481160
175negative regulation of necroptotic process (GO:0060546)2.38902698
176ER-nucleus signaling pathway (GO:0006984)2.37833881
177response to peptidoglycan (GO:0032494)2.36617417
178peptidyl-arginine omega-N-methylation (GO:0035247)2.31938605
179glucose 6-phosphate metabolic process (GO:0051156)2.31593760
180embryo implantation (GO:0007566)2.31498455
181endothelial cell chemotaxis (GO:0035767)2.30047788
182vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27616256
183decidualization (GO:0046697)2.27607592
184positive regulation of myotube differentiation (GO:0010831)2.27329694
185negative regulation of homotypic cell-cell adhesion (GO:0034111)2.26610540
186trophoblast giant cell differentiation (GO:0060707)2.26607317
187positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25772836
188positive regulation of nitric-oxide synthase activity (GO:0051000)2.24864470
189positive regulation of protein export from nucleus (GO:0046827)2.24596307
190planar cell polarity pathway involved in neural tube closure (GO:0090179)2.24505222
191regulation of histone H3-K27 methylation (GO:0061085)2.24080573
192positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.23470528
193negative regulation of fatty acid transport (GO:2000192)2.23163480
194endocytic recycling (GO:0032456)2.22676571
195regulation of defense response to virus by virus (GO:0050690)2.22397840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38226243
2RARB_27405468_Chip-Seq_BRAIN_Mouse2.93980700
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.78671666
4MYC_22102868_ChIP-Seq_BL_Human2.72073814
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69550639
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69271457
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68307418
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.67290278
9DROSHA_22980978_ChIP-Seq_HELA_Human2.63860720
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62975355
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62975355
12GBX2_23144817_ChIP-Seq_PC3_Human2.60964766
13VDR_21846776_ChIP-Seq_THP-1_Human2.51513530
14REST_21632747_ChIP-Seq_MESCs_Mouse2.47955569
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.45349821
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43190499
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41976180
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37560836
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27812204
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.27763193
21E2F7_22180533_ChIP-Seq_HELA_Human2.26273734
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25946850
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.25779672
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25557339
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23425281
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21035372
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17849574
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16065062
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15809691
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15428748
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.09501477
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09397473
33RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08331517
34TP63_17297297_ChIP-ChIP_HaCaT_Human2.05410402
35REST_18959480_ChIP-ChIP_MESCs_Mouse2.04351150
36* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.04098404
37ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03571086
38EED_16625203_ChIP-ChIP_MESCs_Mouse2.02189782
39RACK7_27058665_Chip-Seq_MCF-7_Human2.01996193
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01774867
41SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01455356
42TCF7_22412390_ChIP-Seq_EML_Mouse1.93088770
43ZNF263_19887448_ChIP-Seq_K562_Human1.92709630
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92018699
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.88527545
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86165742
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.81507972
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79342320
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75381780
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73239032
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72000314
52KDM2B_26808549_Chip-Seq_K562_Human1.71216620
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64421753
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.63613738
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62961618
56CLOCK_20551151_ChIP-Seq_293T_Human1.62955300
57AR_21572438_ChIP-Seq_LNCaP_Human1.62827198
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62155362
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61893537
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60782397
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54808608
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54607079
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53743789
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52475815
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50970930
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50411349
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50398882
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.50077419
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.49767119
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48990932
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48135041
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47680332
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47529448
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45436746
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.41940880
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41688512
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41480639
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40836777
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40646345
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40419302
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39877017
82MAF_26560356_Chip-Seq_TH1_Human1.39740582
83* AR_19668381_ChIP-Seq_PC3_Human1.39709727
84MYC_18555785_ChIP-Seq_MESCs_Mouse1.39516156
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39303461
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35508720
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.35471163
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33719757
89MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33438104
90P68_20966046_ChIP-Seq_HELA_Human1.32896846
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32779616
92NCOR1_26117541_ChIP-Seq_K562_Human1.32618090
93VDR_24763502_ChIP-Seq_THP-1_Human1.31127735
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29554765
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29275853
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.28462186
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28385331
98ZNF274_21170338_ChIP-Seq_K562_Hela1.28037686
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27675336
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23530934
101CREB1_26743006_Chip-Seq_LNCaP_Human1.23444675
102ATF3_27146783_Chip-Seq_COLON_Human1.23174423
103* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21831797
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21520115
105* MAF_26560356_Chip-Seq_TH2_Human1.20624539
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20387812
107KDM2B_26808549_Chip-Seq_DND41_Human1.20301431
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19993744
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.18195813
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17441982
111MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17298735
112* SMAD4_21799915_ChIP-Seq_A2780_Human1.16953437
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16599941
114TP53_16413492_ChIP-PET_HCT116_Human1.16224660
115XRN2_22483619_ChIP-Seq_HELA_Human1.16172514
116MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15416104
117* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14651241
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13792876
119SMAD_19615063_ChIP-ChIP_OVARY_Human1.13584485
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.13307914
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13178528
122TP53_20018659_ChIP-ChIP_R1E_Mouse1.13053947
123RUNX1_22412390_ChIP-Seq_EML_Mouse1.11038048
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10867267
125SMC4_20622854_ChIP-Seq_HELA_Human1.10523990
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10465755
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10463018
128P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09833884
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09228328
130UTX_26944678_Chip-Seq_JUKART_Human1.09083368
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08919792
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07633639
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06965741
134GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06902488
135SMAD3_21741376_ChIP-Seq_HESCs_Human1.06769920
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06707270
137THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06030301
138STAT3_23295773_ChIP-Seq_U87_Human1.04767349
139UBF1/2_26484160_Chip-Seq_HMECs_Human1.04355844
140E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03236308
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02773908
142ELF1_20517297_ChIP-Seq_JURKAT_Human1.02385892
143ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01896729
144CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01260428
145SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00645449
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00239720
147LXR_22292898_ChIP-Seq_THP-1_Human1.00050488
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99927837
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99916444
150AHR_22903824_ChIP-Seq_MCF-7_Human0.99363466
151SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99127466
152TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99121526
153NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98240283
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.97468965
155STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97403740
156NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97097057
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.97037850
158TP53_22127205_ChIP-Seq_IMR90_Human0.96101837
159* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95750244
160SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94657297
161MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94062112
162TET1_21490601_ChIP-Seq_MESCs_Mouse0.94057476
163SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93613581
164* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93330986
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93285853
166PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93199661
167CBX2_27304074_Chip-Seq_ESCs_Mouse0.92879891
168ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92612900
169SMAD3_21741376_ChIP-Seq_ESCs_Human0.92443547
170OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91698333
171ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91521952
172SMAD3_21741376_ChIP-Seq_EPCs_Human0.91467182
173RXR_22108803_ChIP-Seq_LS180_Human0.90140998
174HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89787842
175AR_25329375_ChIP-Seq_VCAP_Human0.89640434
176TCF4_23295773_ChIP-Seq_U87_Human0.89393082
177TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89241358
178POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89241358
179ISL1_27105846_Chip-Seq_CPCs_Mouse0.87829328
180TP53_23651856_ChIP-Seq_MEFs_Mouse0.85693307
181TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85506492
182MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84741258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.03125796
2MP0003635_abnormal_synaptic_transmissio3.89723850
3MP0005451_abnormal_body_composition3.52464810
4MP0002877_abnormal_melanocyte_morpholog3.43675487
5MP0003880_abnormal_central_pattern3.28440872
6MP0002063_abnormal_learning/memory/cond3.19637816
7MP0004270_analgesia2.89983999
8MP0009745_abnormal_behavioral_response2.88428503
9MP0009046_muscle_twitch2.88089682
10MP0005058_abnormal_lysosome_morphology2.86545646
11MP0002064_seizures2.74864756
12MP0008438_abnormal_cutaneous_collagen2.57566357
13MP0002572_abnormal_emotion/affect_behav2.43948578
14MP0001968_abnormal_touch/_nociception2.22647043
15MP0009840_abnormal_foam_cell2.21085917
16MP0005423_abnormal_somatic_nervous2.18714500
17MP0001486_abnormal_startle_reflex2.17108674
18MP0009278_abnormal_bone_marrow2.12063769
19MP0004858_abnormal_nervous_system2.11140260
20MP0003436_decreased_susceptibility_to2.09837293
21MP0003300_gastrointestinal_ulcer2.09329831
22MP0004185_abnormal_adipocyte_glucose2.07858094
23MP0008260_abnormal_autophagy2.03958402
24MP0003566_abnormal_cell_adhesion2.03896565
25MP0002272_abnormal_nervous_system1.94255280
26MP0003453_abnormal_keratinocyte_physiol1.92358686
27MP0002734_abnormal_mechanical_nocicepti1.92287837
28MP0008569_lethality_at_weaning1.88298299
29MP0003091_abnormal_cell_migration1.87981745
30MP0003787_abnormal_imprinting1.87290831
31MP0000778_abnormal_nervous_system1.86603058
32MP0000569_abnormal_digit_pigmentation1.86579408
33MP0002822_catalepsy1.86499220
34MP0001849_ear_inflammation1.83160052
35MP0002184_abnormal_innervation1.82575110
36MP0001501_abnormal_sleep_pattern1.78905364
37MP0004947_skin_inflammation1.75984101
38MP0004811_abnormal_neuron_physiology1.74731126
39MP0001348_abnormal_lacrimal_gland1.72053895
40MP0001440_abnormal_grooming_behavior1.67492742
41MP0002067_abnormal_sensory_capabilities1.65270061
42MP0003191_abnormal_cellular_cholesterol1.65229994
43MP0002735_abnormal_chemical_nociception1.63428359
44MP0010352_gastrointestinal_tract_polyps1.63376343
45MP0009780_abnormal_chondrocyte_physiolo1.62986428
46MP0003122_maternal_imprinting1.61299374
47MP0004233_abnormal_muscle_weight1.61115329
48MP0003283_abnormal_digestive_organ1.58049399
49MP0002736_abnormal_nociception_after1.57571731
50MP0000955_abnormal_spinal_cord1.55669627
51MP0002733_abnormal_thermal_nociception1.55081537
52MP0002557_abnormal_social/conspecific_i1.50956061
53MP0009333_abnormal_splenocyte_physiolog1.50911699
54MP0000678_abnormal_parathyroid_gland1.50910673
55MP0008004_abnormal_stomach_pH1.49971866
56MP0005257_abnormal_intraocular_pressure1.49297459
57MP0000858_altered_metastatic_potential1.46823595
58MP0000751_myopathy1.45651842
59MP0002909_abnormal_adrenal_gland1.45248556
60MP0001970_abnormal_pain_threshold1.43520081
61MP0005666_abnormal_adipose_tissue1.43449433
62MP0002882_abnormal_neuron_morphology1.40219376
63MP0003123_paternal_imprinting1.37864934
64MP0003279_aneurysm1.37701171
65MP0003111_abnormal_nucleus_morphology1.35968791
66MP0005646_abnormal_pituitary_gland1.35756108
67MP0002653_abnormal_ependyma_morphology1.32823182
68MP0004808_abnormal_hematopoietic_stem1.31506080
69MP0004924_abnormal_behavior1.30816299
70MP0005386_behavior/neurological_phenoty1.30816299
71MP0002152_abnormal_brain_morphology1.30477762
72MP0008961_abnormal_basal_metabolism1.28436696
73MP0003879_abnormal_hair_cell1.28231204
74MP0000733_abnormal_muscle_development1.26477248
75MP0002066_abnormal_motor_capabilities/c1.26061410
76MP0005623_abnormal_meninges_morphology1.24802525
77MP0005375_adipose_tissue_phenotype1.21924357
78MP0001502_abnormal_circadian_rhythm1.21209079
79MP0005621_abnormal_cell_physiology1.20905807
80MP0010030_abnormal_orbit_morphology1.20859586
81MP0001730_embryonic_growth_arrest1.18500338
82MP0002998_abnormal_bone_remodeling1.18155448
83MP0000750_abnormal_muscle_regeneration1.17750182
84MP0004885_abnormal_endolymph1.16913367
85MP0000350_abnormal_cell_proliferation1.15409662
86MP0003329_amyloid_beta_deposits1.15282264
87MP0004145_abnormal_muscle_electrophysio1.15144979
88MP0000604_amyloidosis1.14156579
89MP0002332_abnormal_exercise_endurance1.13444905
90MP0004510_myositis1.12637758
91MP0002796_impaired_skin_barrier1.11471932
92MP0005023_abnormal_wound_healing1.10771141
93MP0003121_genomic_imprinting1.09909724
94MP0001984_abnormal_olfaction1.09176338
95MP0003633_abnormal_nervous_system1.06493444
96MP0005000_abnormal_immune_tolerance1.04634990
97MP0005076_abnormal_cell_differentiation1.03692333
98MP0005248_abnormal_Harderian_gland1.02721450
99MP0003861_abnormal_nervous_system1.02182984
100MP0003763_abnormal_thymus_physiology1.02046039
101MP0000747_muscle_weakness1.00036021
102MP0003448_altered_tumor_morphology0.99781241
103MP0001853_heart_inflammation0.99487471
104MP0000003_abnormal_adipose_tissue0.98673267
105MP0003890_abnormal_embryonic-extraembry0.97587007
106MP0005501_abnormal_skin_physiology0.97261399
107MP0010234_abnormal_vibrissa_follicle0.97194963
108MP0009672_abnormal_birth_weight0.95542466
109MP0003137_abnormal_impulse_conducting0.95172653
110MP0003119_abnormal_digestive_system0.93634579
111MP0001533_abnormal_skeleton_physiology0.93325456
112MP0003705_abnormal_hypodermis_morpholog0.92006000
113MP0002060_abnormal_skin_morphology0.91843666
114MP0000343_altered_response_to0.91388532
115MP0005645_abnormal_hypothalamus_physiol0.90523862
116MP0005394_taste/olfaction_phenotype0.89739910
117MP0005499_abnormal_olfactory_system0.89739910
118MP0002249_abnormal_larynx_morphology0.89057372
119MP0002896_abnormal_bone_mineralization0.88848279
120MP0003631_nervous_system_phenotype0.88747508
121MP0000490_abnormal_crypts_of0.86197713
122MP0002090_abnormal_vision0.86126523
123MP0001299_abnormal_eye_distance/0.85325143
124MP0001545_abnormal_hematopoietic_system0.84931943
125MP0005397_hematopoietic_system_phenotyp0.84931943
126MP0001346_abnormal_lacrimal_gland0.83670543
127MP0005390_skeleton_phenotype0.82231986
128MP0004142_abnormal_muscle_tone0.82125286
129MP0000534_abnormal_ureter_morphology0.82074718
130MP0003075_altered_response_to0.82013136
131MP0005551_abnormal_eye_electrophysiolog0.81560937
132MP0005384_cellular_phenotype0.81090091
133MP0001881_abnormal_mammary_gland0.81030799
134MP0004085_abnormal_heartbeat0.80739255
135MP0005508_abnormal_skeleton_morphology0.80497980
136MP0000313_abnormal_cell_death0.80463014
137MP0003045_fibrosis0.80281400
138MP0002089_abnormal_postnatal_growth/wei0.80058923
139MP0000767_abnormal_smooth_muscle0.79661889
140MP0008007_abnormal_cellular_replicative0.79645091
141MP0002080_prenatal_lethality0.78855252
142MP0005166_decreased_susceptibility_to0.78383370
143MP0002069_abnormal_eating/drinking_beha0.78192828
144MP0003221_abnormal_cardiomyocyte_apopto0.78170333
145MP0003077_abnormal_cell_cycle0.77827991
146MP0002148_abnormal_hypersensitivity_rea0.77654501
147MP0001177_atelectasis0.77343770
148MP0003385_abnormal_body_wall0.75890503
149MP0000631_abnormal_neuroendocrine_gland0.75727392
150MP0000462_abnormal_digestive_system0.75260495
151MP0006072_abnormal_retinal_apoptosis0.75233858
152MP0004215_abnormal_myocardial_fiber0.74970743
153MP0004087_abnormal_muscle_fiber0.74554070
154MP0003172_abnormal_lysosome_physiology0.74509528
155MP0004957_abnormal_blastocyst_morpholog0.74321359
156MP0004272_abnormal_basement_membrane0.74255527
157MP0005187_abnormal_penis_morphology0.73675851
158MP0002398_abnormal_bone_marrow0.72722131
159MP0003656_abnormal_erythrocyte_physiolo0.72667552
160MP0003303_peritoneal_inflammation0.72385086
161MP0003634_abnormal_glial_cell0.72177779
162MP0002419_abnormal_innate_immunity0.72140202
163MP0002752_abnormal_somatic_nervous0.72049162
164MP0002234_abnormal_pharynx_morphology0.71689256
165MP0010307_abnormal_tumor_latency0.70609162
166MP0003693_abnormal_embryo_hatching0.68518529
167MP0001915_intracranial_hemorrhage0.67933001
168MP0009931_abnormal_skin_appearance0.67596763
169MP0005165_increased_susceptibility_to0.67449649
170MP0003632_abnormal_nervous_system0.67284093
171MP0010769_abnormal_survival0.67193083
172MP0001542_abnormal_bone_strength0.66621866
173MP0000759_abnormal_skeletal_muscle0.66109182
174MP0002254_reproductive_system_inflammat0.65700795
175MP0004133_heterotaxia0.65655588
176MP0010630_abnormal_cardiac_muscle0.65575691
177MP0008874_decreased_physiological_sensi0.64675217
178MP0002081_perinatal_lethality0.63921178
179MP0010768_mortality/aging0.63838780
180MP0006292_abnormal_olfactory_placode0.63188487
181MP0010770_preweaning_lethality0.62667047
182MP0002082_postnatal_lethality0.62667047
183MP0004130_abnormal_muscle_cell0.61923813

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.38233262
2Myokymia (HP:0002411)5.02264942
3Focal seizures (HP:0007359)4.49101369
4Visual hallucinations (HP:0002367)3.88960739
5Epileptic encephalopathy (HP:0200134)3.82342581
6Progressive cerebellar ataxia (HP:0002073)3.37351541
7Premature rupture of membranes (HP:0001788)3.34876963
8Protrusio acetabuli (HP:0003179)3.26756285
9Action tremor (HP:0002345)3.26197201
10Absence seizures (HP:0002121)3.18871183
11Febrile seizures (HP:0002373)3.17163009
12Atonic seizures (HP:0010819)3.16903641
13Annular pancreas (HP:0001734)3.10364425
14Abnormality of the lower motor neuron (HP:0002366)3.10187063
15Dysdiadochokinesis (HP:0002075)3.04088997
16Vertebral compression fractures (HP:0002953)3.01212437
17Dialeptic seizures (HP:0011146)2.93477260
18Distal lower limb amyotrophy (HP:0008944)2.85018436
19Genetic anticipation (HP:0003743)2.83369725
20Generalized tonic-clonic seizures (HP:0002069)2.81722664
21Broad-based gait (HP:0002136)2.80495512
22Poor eye contact (HP:0000817)2.79275673
23Abnormality of the Achilles tendon (HP:0005109)2.68260929
24Depression (HP:0000716)2.64167673
25Abnormal gallbladder physiology (HP:0012438)2.63193475
26Cholecystitis (HP:0001082)2.63193475
27Pointed chin (HP:0000307)2.62629438
28Impaired social interactions (HP:0000735)2.60308420
29Abnormal social behavior (HP:0012433)2.60308420
30Gaze-evoked nystagmus (HP:0000640)2.59476801
31Dysmetric saccades (HP:0000641)2.59446528
32Distal upper limb amyotrophy (HP:0007149)2.57854933
33Upper limb amyotrophy (HP:0009129)2.57854933
34Long palpebral fissure (HP:0000637)2.45010250
35Impaired smooth pursuit (HP:0007772)2.40491105
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.40259823
37Cerebral inclusion bodies (HP:0100314)2.37873347
38Shallow orbits (HP:0000586)2.36222815
39Increased connective tissue (HP:0009025)2.35527365
40Neurofibrillary tangles (HP:0002185)2.34409105
41Impaired vibration sensation in the lower limbs (HP:0002166)2.34332971
42Distal lower limb muscle weakness (HP:0009053)2.32079303
43Truncal ataxia (HP:0002078)2.30720901
44Macroorchidism (HP:0000053)2.30649167
45Ulnar bowing (HP:0003031)2.28168652
46Dysmetria (HP:0001310)2.27984399
47Drooling (HP:0002307)2.27314095
48Excessive salivation (HP:0003781)2.27314095
49Hyperparathyroidism (HP:0000843)2.25680005
50Abnormality of the astrocytes (HP:0100707)2.22367695
51Astrocytoma (HP:0009592)2.22367695
52Relative macrocephaly (HP:0004482)2.22134105
53Neuronal loss in central nervous system (HP:0002529)2.21471602
54Stereotypic behavior (HP:0000733)2.20653056
55Hemiplegia (HP:0002301)2.19624184
56Urinary bladder sphincter dysfunction (HP:0002839)2.18881212
57Absent speech (HP:0001344)2.18469334
58Hyperacusis (HP:0010780)2.18235164
59Amblyopia (HP:0000646)2.14380064
60Megalencephaly (HP:0001355)2.14062858
61Mutism (HP:0002300)2.12431942
62Abnormality of ocular smooth pursuit (HP:0000617)2.12214127
63Hemiparesis (HP:0001269)2.09755048
64Spinal rigidity (HP:0003306)2.08586962
65Mitral regurgitation (HP:0001653)2.08107701
66Diplopia (HP:0000651)2.07737255
67Abnormality of binocular vision (HP:0011514)2.07737255
68Insomnia (HP:0100785)2.07157082
69Lower limb amyotrophy (HP:0007210)2.06124318
70Hand muscle atrophy (HP:0009130)2.05171211
71Ankle clonus (HP:0011448)2.04739682
72Trismus (HP:0000211)2.02638523
73Abnormality of the thoracic spine (HP:0100711)2.01309441
74Broad face (HP:0000283)2.01070091
75Supranuclear gaze palsy (HP:0000605)2.00617342
76Hypercortisolism (HP:0001578)1.99701052
77Disproportionate tall stature (HP:0001519)1.99132508
78Turricephaly (HP:0000262)1.97087819
79Abnormal eating behavior (HP:0100738)1.96897959
80Increased variability in muscle fiber diameter (HP:0003557)1.96733182
81Epileptiform EEG discharges (HP:0011182)1.95324135
82Status epilepticus (HP:0002133)1.95264537
83Cerebral aneurysm (HP:0004944)1.93625236
84Postural instability (HP:0002172)1.93511716
85Fragile skin (HP:0001030)1.93304396
86Thin bony cortex (HP:0002753)1.93014624
87Neoplasm of the heart (HP:0100544)1.91700780
88Ankle contracture (HP:0006466)1.90978438
89Dysostosis multiplex (HP:0000943)1.90167378
90Abnormality of skeletal muscle fiber size (HP:0012084)1.89664211
91Obstructive sleep apnea (HP:0002870)1.88774755
92Abnormality of the distal phalanx of the thumb (HP:0009617)1.88215304
93Renal duplication (HP:0000075)1.88067566
94Generalized amyotrophy (HP:0003700)1.87273739
95Myopathic facies (HP:0002058)1.86847727
96Diminished motivation (HP:0000745)1.86475493
97EEG with generalized epileptiform discharges (HP:0011198)1.86046156
98Osteolytic defects of the phalanges of the hand (HP:0009771)1.85890394
99Osteolytic defects of the hand bones (HP:0009699)1.85890394
100Abnormality of the phalanges of the hallux (HP:0010057)1.85427725
101Thoracic kyphosis (HP:0002942)1.85101679
102Cellulitis (HP:0100658)1.85047726
103Aqueductal stenosis (HP:0002410)1.84992062
104Short nail (HP:0001799)1.83610090
105Segmental peripheral demyelination/remyelination (HP:0003481)1.82850288
106Blue sclerae (HP:0000592)1.80702441
107Hepatoblastoma (HP:0002884)1.77731495
108Reticulocytosis (HP:0001923)1.77361104
109Loss of speech (HP:0002371)1.77128827
110Anxiety (HP:0000739)1.76933533
111Urinary urgency (HP:0000012)1.76830818
112Wormian bones (HP:0002645)1.76805049
113Abnormality of the aortic arch (HP:0012303)1.76754315
114Abnormality of glycolipid metabolism (HP:0010969)1.76552045
115Abnormality of liposaccharide metabolism (HP:0010968)1.76552045
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.76552045
117Torticollis (HP:0000473)1.75707288
118Elfin facies (HP:0004428)1.74854698
119Spinal cord lesions (HP:0100561)1.74751641
120Syringomyelia (HP:0003396)1.74751641
121Nuclear cataract (HP:0100018)1.73002292
122Abnormal ossification of hand bones (HP:0005921)1.73001403
123Incomplete penetrance (HP:0003829)1.72738735
124Genu recurvatum (HP:0002816)1.72667186
125Axonal loss (HP:0003447)1.72401590
126Hypsarrhythmia (HP:0002521)1.72262179
127Progressive muscle weakness (HP:0003323)1.72207475
128Patellar dislocation (HP:0002999)1.70910184
129Distal sensory impairment (HP:0002936)1.70668704
130Hyperventilation (HP:0002883)1.70434031
131Spinal cord compression (HP:0002176)1.70097436
132Difficulty climbing stairs (HP:0003551)1.69988953
133Elbow flexion contracture (HP:0002987)1.69687872
134Upper motor neuron abnormality (HP:0002127)1.68127399
135Dilatation of the ascending aorta (HP:0005111)1.67958671
136Bradykinesia (HP:0002067)1.67836188
137Bladder diverticulum (HP:0000015)1.67689882
138Abnormality of carpal bone ossification (HP:0006257)1.66297441
139Back pain (HP:0003418)1.65824172
140Papilledema (HP:0001085)1.65241816
141Abnormality of the distal phalanges of the toes (HP:0010182)1.64753457
142Interstitial pulmonary disease (HP:0006530)1.64207804
143Narrow nasal bridge (HP:0000446)1.63820405
144Lower limb asymmetry (HP:0100559)1.63612173
145Peripheral hypomyelination (HP:0007182)1.63109266
146Abnormality of oral frenula (HP:0000190)1.63053033
147Overriding aorta (HP:0002623)1.62921513
148Slow saccadic eye movements (HP:0000514)1.62914114
149Ragged-red muscle fibers (HP:0003200)1.62752786
150Autism (HP:0000717)1.61790098
151Hypertensive crisis (HP:0100735)1.61524052
152Polygenic inheritance (HP:0010982)1.60330836
153Intention tremor (HP:0002080)1.60150477
154Inappropriate behavior (HP:0000719)1.60050753
155Rough bone trabeculation (HP:0100670)1.59820916
156Cupped ribs (HP:0000887)1.59751362
157Ventricular fibrillation (HP:0001663)1.59660904
158Abnormality of the labia minora (HP:0012880)1.59167710
159Impaired vibratory sensation (HP:0002495)1.59163253
160Scanning speech (HP:0002168)1.59094622
161Fatigue (HP:0012378)1.58757752
162Abnormality of the umbilical cord (HP:0010881)1.58553681
163Mildly elevated creatine phosphokinase (HP:0008180)1.58389944
164Focal dystonia (HP:0004373)1.58257603
165Stridor (HP:0010307)1.58145186
166Obsessive-compulsive behavior (HP:0000722)1.57899351
167Deep palmar crease (HP:0006191)1.57717828
168Ankyloglossia (HP:0010296)1.57700179
169Abnormal EKG (HP:0003115)1.57556045
170Bowel incontinence (HP:0002607)1.56862391
171Asymmetry of the thorax (HP:0001555)1.56688801
172Glioma (HP:0009733)1.56672673
173Deeply set eye (HP:0000490)1.56476771
174Bone pain (HP:0002653)1.55051886
175Open mouth (HP:0000194)1.54900078
176Hammertoe (HP:0001765)1.54884574
177Overgrowth (HP:0001548)1.53177744
178Spinal canal stenosis (HP:0003416)1.50916854
179Generalized hypotonia (HP:0001290)1.50106000
180Bronchomalacia (HP:0002780)1.49049282
181Resting tremor (HP:0002322)1.47805644
182Achilles tendon contracture (HP:0001771)1.47729383
183Narrow palate (HP:0000189)1.47669280
184Exercise-induced myalgia (HP:0003738)1.47450750
185Amyotrophic lateral sclerosis (HP:0007354)1.47343757
186Apathy (HP:0000741)1.47279544
187Bundle branch block (HP:0011710)1.47091943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.40654698
2EPHA44.22846096
3MAP3K94.15761101
4IRAK33.99220751
5SMG13.01628210
6NME22.84912583
7* PRPF4B2.83407140
8PAK62.71485591
9MARK12.61978095
10PRKD32.49544725
11EEF2K2.48193601
12DAPK22.45409247
13SIK12.37295738
14KSR12.28975398
15MINK12.28432174
16MAP3K42.25393955
17KSR22.22544437
18ERN12.18618875
19CAMKK11.98307270
20DAPK11.86629707
21TYRO31.82126680
22SIK21.80657093
23NTRK21.77532205
24STK381.69627110
25TESK11.61586886
26LATS21.59190894
27TTN1.49994651
28DDR21.42676707
29TRIB31.40870206
30CDK51.36673022
31MAP2K31.31784144
32RIPK11.29486745
33TESK21.27704061
34BMX1.25739573
35PDGFRA1.25344313
36ICK1.22171260
37MAP2K41.22106478
38CDK121.21305077
39TAOK11.20899829
40MAP3K111.20145243
41MOS1.19889320
42UHMK11.19238724
43NTRK11.18708166
44PIM21.18033712
45PHKG21.16410702
46PHKG11.16410702
47BRAF1.15072798
48MAP2K71.09395590
49RIPK41.09165219
50ALK1.07222811
51PAK41.05199797
52MAP3K141.03830271
53MAP3K11.03679348
54IRAK21.02815472
55MAP3K131.01055696
56MAP3K100.98229659
57MAP3K30.96269090
58CAMKK20.95139098
59TBK10.94068928
60CDK180.93622803
61CDK150.91082771
62STK110.90943519
63PRKCG0.90777813
64MAPK130.90201624
65MAP3K80.90094989
66PLK20.89596688
67TNIK0.87761236
68FGFR40.87408262
69SIK30.87092095
70CDC42BPA0.86045107
71CDK140.84452853
72LMTK20.84212225
73NEK10.82088792
74CAMK40.80038851
75PRKCH0.79618260
76PINK10.79615221
77CAMK10.79531304
78CAMK1G0.78779255
79PRKD20.78690368
80MARK20.77856430
81PAK30.77501659
82RAF10.77415918
83EPHA20.77270615
84CDK11A0.77256624
85SGK30.76799064
86FES0.75937294
87PTK2B0.74892157
88PKN20.74375074
89MAP3K20.74222054
90SGK10.73459896
91FGR0.72135988
92CDK70.71648643
93RET0.71584298
94CASK0.71551346
95TNK20.71536072
96DMPK0.71057959
97CDK40.70141677
98SGK20.69668532
99RPS6KA20.67789013
100CAMK2A0.66919800
101MAPK110.66132049
102MAP3K70.65601599
103HIPK20.65430807
104* TAOK20.65329455
105MAPK100.63524590
106IRAK40.62867958
107PAK10.62581168
108GRK50.62279727
109CLK10.61982786
110ARAF0.61585763
111RPS6KA30.60187328
112SGK4940.58959489
113SGK2230.58959489
114DYRK1A0.58839809
115MAP4K10.58038722
116CAMK1D0.56934993
117MAP3K60.56749592
118MAPK120.56150239
119LIMK10.55938020
120DAPK30.55611200
121RPS6KL10.55220537
122RPS6KC10.55220537
123ILK0.53160005
124PAK20.51935019
125FER0.51932626
126PRKCZ0.51019531
127RPS6KB20.50876078
128EPHB10.50810931
129WNK10.49066153
130LRRK20.47427244
131LATS10.47322437
132ABL20.47183108
133PDK10.46942498
134PDPK10.46811616
135ERBB30.46463897
136PTK20.46089927
137CAMK2B0.46049810
138PTK60.45775650
139SCYL20.45514429
140JAK10.44078680
141FGFR10.43786514
142BRD40.43599551
143AKT20.43446075
144CDK60.43322056
145TYK20.42999891
146AKT30.42536637
147MAP3K120.41221168
148MTOR0.40591028
149FYN0.39511172
150PRKG20.39133399
151CDK190.38694220
152MAPK80.38551554
153CDK90.38351336
154CDK80.37586030
155BRSK10.37574589
156BUB10.37327578
157AURKA0.37050077
158MAP2K20.36300944

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.06840685
2Synaptic vesicle cycle_Homo sapiens_hsa047212.53378242
3Long-term potentiation_Homo sapiens_hsa047202.51130002
4Circadian entrainment_Homo sapiens_hsa047132.40501433
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.38642839
6Olfactory transduction_Homo sapiens_hsa047402.33963701
7Glutamatergic synapse_Homo sapiens_hsa047242.32913472
8GABAergic synapse_Homo sapiens_hsa047272.29155741
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22892485
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.19255373
11Morphine addiction_Homo sapiens_hsa050322.18234389
12Amphetamine addiction_Homo sapiens_hsa050311.99058612
13Other glycan degradation_Homo sapiens_hsa005111.96545063
14Acute myeloid leukemia_Homo sapiens_hsa052211.86862229
15Dopaminergic synapse_Homo sapiens_hsa047281.85102855
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78537303
17Cholinergic synapse_Homo sapiens_hsa047251.75011223
18Salivary secretion_Homo sapiens_hsa049701.74074048
19* Prion diseases_Homo sapiens_hsa050201.68799953
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68054497
21Insulin secretion_Homo sapiens_hsa049111.67597625
22* Oxytocin signaling pathway_Homo sapiens_hsa049211.66107279
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65407579
24Pancreatic cancer_Homo sapiens_hsa052121.60009602
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55928454
26Long-term depression_Homo sapiens_hsa047301.54642731
27Glioma_Homo sapiens_hsa052141.51880300
28Pentose phosphate pathway_Homo sapiens_hsa000301.48718093
29Gastric acid secretion_Homo sapiens_hsa049711.46306039
30Renin secretion_Homo sapiens_hsa049241.44930768
31* GnRH signaling pathway_Homo sapiens_hsa049121.42272617
32B cell receptor signaling pathway_Homo sapiens_hsa046621.40141442
33Calcium signaling pathway_Homo sapiens_hsa040201.39476003
34Type II diabetes mellitus_Homo sapiens_hsa049301.39151032
35Gap junction_Homo sapiens_hsa045401.38016712
36Taste transduction_Homo sapiens_hsa047421.35544927
37Cocaine addiction_Homo sapiens_hsa050301.32874286
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32762834
39TNF signaling pathway_Homo sapiens_hsa046681.32425996
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29602079
41Estrogen signaling pathway_Homo sapiens_hsa049151.27227204
42Axon guidance_Homo sapiens_hsa043601.25679037
43mTOR signaling pathway_Homo sapiens_hsa041501.24523939
44Shigellosis_Homo sapiens_hsa051311.23625014
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23541436
46* Hepatitis B_Homo sapiens_hsa051611.23484502
47Osteoclast differentiation_Homo sapiens_hsa043801.21789074
48Biosynthesis of amino acids_Homo sapiens_hsa012301.21474738
49cAMP signaling pathway_Homo sapiens_hsa040241.20049631
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.19155350
51* ErbB signaling pathway_Homo sapiens_hsa040121.18964611
52Serotonergic synapse_Homo sapiens_hsa047261.17691907
53Thyroid cancer_Homo sapiens_hsa052161.16839111
54Apoptosis_Homo sapiens_hsa042101.14066080
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14059599
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13249502
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13145600
58Dilated cardiomyopathy_Homo sapiens_hsa054141.11629417
59Melanogenesis_Homo sapiens_hsa049161.09231823
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08822961
61VEGF signaling pathway_Homo sapiens_hsa043701.07729671
62Phospholipase D signaling pathway_Homo sapiens_hsa040721.07656655
63Notch signaling pathway_Homo sapiens_hsa043301.06571149
64Hepatitis C_Homo sapiens_hsa051601.05723408
65Vibrio cholerae infection_Homo sapiens_hsa051101.03793540
66Fructose and mannose metabolism_Homo sapiens_hsa000511.02465069
67Salmonella infection_Homo sapiens_hsa051321.01151445
68Vitamin B6 metabolism_Homo sapiens_hsa007501.00428686
69Glycosaminoglycan degradation_Homo sapiens_hsa005311.00281884
70Oocyte meiosis_Homo sapiens_hsa041140.99750431
71Prolactin signaling pathway_Homo sapiens_hsa049170.99645661
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99562773
73Influenza A_Homo sapiens_hsa051640.99019592
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97982322
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.97703738
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97600175
77Small cell lung cancer_Homo sapiens_hsa052220.96046044
78Dorso-ventral axis formation_Homo sapiens_hsa043200.95184888
79Galactose metabolism_Homo sapiens_hsa000520.94863455
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94697738
81Choline metabolism in cancer_Homo sapiens_hsa052310.91943689
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91536655
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91274742
84Non-small cell lung cancer_Homo sapiens_hsa052230.91042332
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90319426
86* MAPK signaling pathway_Homo sapiens_hsa040100.90131136
87Amoebiasis_Homo sapiens_hsa051460.87290026
88Toxoplasmosis_Homo sapiens_hsa051450.87108112
89* Endometrial cancer_Homo sapiens_hsa052130.86724028
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84848951
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84653971
92Circadian rhythm_Homo sapiens_hsa047100.82705408
93Prostate cancer_Homo sapiens_hsa052150.81972155
94* HTLV-I infection_Homo sapiens_hsa051660.81961353
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80720823
96Rap1 signaling pathway_Homo sapiens_hsa040150.80519352
97Viral carcinogenesis_Homo sapiens_hsa052030.80365403
98Sulfur relay system_Homo sapiens_hsa041220.80272200
99Colorectal cancer_Homo sapiens_hsa052100.79845052
100Wnt signaling pathway_Homo sapiens_hsa043100.79682780
101Measles_Homo sapiens_hsa051620.79603712
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79403582
103Renal cell carcinoma_Homo sapiens_hsa052110.79195037
104DNA replication_Homo sapiens_hsa030300.78306399
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.77295220
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.74955585
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74362152
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73590923
109Epstein-Barr virus infection_Homo sapiens_hsa051690.73375821
110Lysosome_Homo sapiens_hsa041420.72130795
111Tuberculosis_Homo sapiens_hsa051520.72000932
112Herpes simplex infection_Homo sapiens_hsa051680.71886664
113AMPK signaling pathway_Homo sapiens_hsa041520.71596972
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70815621
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70748225
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70731501
117Glucagon signaling pathway_Homo sapiens_hsa049220.70535790
118Hedgehog signaling pathway_Homo sapiens_hsa043400.69425526
119Hippo signaling pathway_Homo sapiens_hsa043900.69365636
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68039545
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.67952278
122T cell receptor signaling pathway_Homo sapiens_hsa046600.65620343
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64826130
124Chronic myeloid leukemia_Homo sapiens_hsa052200.64652801
125* Proteoglycans in cancer_Homo sapiens_hsa052050.64615638
126* Ras signaling pathway_Homo sapiens_hsa040140.64601437
127Carbon metabolism_Homo sapiens_hsa012000.64079515
128* Insulin signaling pathway_Homo sapiens_hsa049100.62461988
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59810105
130* Leishmaniasis_Homo sapiens_hsa051400.59418351
131Legionellosis_Homo sapiens_hsa051340.59322149
132Malaria_Homo sapiens_hsa051440.58921872
133Thyroid hormone synthesis_Homo sapiens_hsa049180.58596415
134Cardiac muscle contraction_Homo sapiens_hsa042600.58318759
135Endocytosis_Homo sapiens_hsa041440.58063841
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58032715
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57571347
138Cell cycle_Homo sapiens_hsa041100.57040546
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56789691
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56107808
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.55915175
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54839750
143Inositol phosphate metabolism_Homo sapiens_hsa005620.54782121
144Melanoma_Homo sapiens_hsa052180.54460444
145Bladder cancer_Homo sapiens_hsa052190.54392406
146Pertussis_Homo sapiens_hsa051330.54162601
147mRNA surveillance pathway_Homo sapiens_hsa030150.52645388
148Basal cell carcinoma_Homo sapiens_hsa052170.52467249
149Pancreatic secretion_Homo sapiens_hsa049720.51112525
150Chemokine signaling pathway_Homo sapiens_hsa040620.49915899
151HIF-1 signaling pathway_Homo sapiens_hsa040660.49634345
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49426935
153Adherens junction_Homo sapiens_hsa045200.49108803
154Collecting duct acid secretion_Homo sapiens_hsa049660.48542518
155Phototransduction_Homo sapiens_hsa047440.47891188
156* Focal adhesion_Homo sapiens_hsa045100.46758700
157MicroRNAs in cancer_Homo sapiens_hsa052060.46252013
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46095837

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