EIF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.13738078
2purine nucleobase biosynthetic process (GO:0009113)4.98087252
3DNA deamination (GO:0045006)4.96272115
4nucleobase biosynthetic process (GO:0046112)4.81918326
5maturation of SSU-rRNA (GO:0030490)4.81833941
6establishment of integrated proviral latency (GO:0075713)4.67312084
7proteasome assembly (GO:0043248)4.57495646
8formation of translation preinitiation complex (GO:0001731)4.50921136
9establishment of viral latency (GO:0019043)4.37513618
10ribosome biogenesis (GO:0042254)4.29861375
11* ribosome assembly (GO:0042255)4.09715811
12mitotic metaphase plate congression (GO:0007080)4.09547421
13ribosomal small subunit assembly (GO:0000028)4.05430128
14* ribonucleoprotein complex biogenesis (GO:0022613)3.92588299
15DNA strand elongation involved in DNA replication (GO:0006271)3.91761873
16folic acid metabolic process (GO:0046655)3.89061745
17COPI coating of Golgi vesicle (GO:0048205)3.85635922
18Golgi transport vesicle coating (GO:0048200)3.85635922
19viral transcription (GO:0019083)3.85573280
20DNA replication initiation (GO:0006270)3.83445661
21translational termination (GO:0006415)3.83111770
22ribosomal small subunit biogenesis (GO:0042274)3.81023692
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.77829268
24regulation of mitochondrial translation (GO:0070129)3.77499018
25DNA replication checkpoint (GO:0000076)3.73831806
26anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72450748
27DNA strand elongation (GO:0022616)3.71086155
28* translational initiation (GO:0006413)3.70051027
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68599643
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66886790
31rRNA processing (GO:0006364)3.66231347
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.65429447
33rRNA modification (GO:0000154)3.65403026
34folic acid-containing compound biosynthetic process (GO:0009396)3.63574721
35telomere maintenance via semi-conservative replication (GO:0032201)3.59879693
36GDP-mannose metabolic process (GO:0019673)3.57882920
37translational elongation (GO:0006414)3.56618969
38rRNA metabolic process (GO:0016072)3.54140262
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.49452324
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.49051975
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43329346
42negative regulation of ligase activity (GO:0051352)3.43329346
43protein localization to kinetochore (GO:0034501)3.42558859
44mitotic nuclear envelope disassembly (GO:0007077)3.39177988
45chaperone-mediated protein transport (GO:0072321)3.39089361
46protein targeting to mitochondrion (GO:0006626)3.38344408
47IMP biosynthetic process (GO:0006188)3.38334622
48* ribosomal large subunit biogenesis (GO:0042273)3.38216747
49regulation of cellular amine metabolic process (GO:0033238)3.38098049
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.37279952
51termination of RNA polymerase III transcription (GO:0006386)3.37279952
52spliceosomal snRNP assembly (GO:0000387)3.35355528
53pseudouridine synthesis (GO:0001522)3.31088637
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29942077
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24664073
56telomere maintenance via recombination (GO:0000722)3.24437605
57protein deneddylation (GO:0000338)3.24329623
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24130438
59metaphase plate congression (GO:0051310)3.23092049
60cullin deneddylation (GO:0010388)3.22421930
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21446205
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21446205
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21446205
64nuclear envelope reassembly (GO:0031468)3.21414383
65mitotic nuclear envelope reassembly (GO:0007084)3.21414383
66regulation of cellular amino acid metabolic process (GO:0006521)3.20928917
67signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19861379
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.19861379
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18911915
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18911915
71nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18303067
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.14802437
73positive regulation of ligase activity (GO:0051351)3.13872525
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.13788822
75protein targeting to ER (GO:0045047)3.13777413
76cotranslational protein targeting to membrane (GO:0006613)3.12774059
77membrane disassembly (GO:0030397)3.12347408
78nuclear envelope disassembly (GO:0051081)3.12347408
79negative regulation of protein ubiquitination (GO:0031397)3.12171393
80translation (GO:0006412)3.11229201
81DNA replication-dependent nucleosome assembly (GO:0006335)3.10752414
82DNA replication-dependent nucleosome organization (GO:0034723)3.10752414
83DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.10010079
84regulation of spindle organization (GO:0090224)3.09475478
85G1/S transition of mitotic cell cycle (GO:0000082)3.04598653
86cell cycle G1/S phase transition (GO:0044843)3.04598653
87viral life cycle (GO:0019058)3.03563701
88cellular protein complex disassembly (GO:0043624)3.01869641
89establishment of protein localization to mitochondrion (GO:0072655)3.01236853
90DNA unwinding involved in DNA replication (GO:0006268)3.01130607
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00813692
92IMP metabolic process (GO:0046040)3.00176623
93negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.00155841
94protein localization to chromosome, centromeric region (GO:0071459)2.99740065
95nucleoside salvage (GO:0043174)2.98792567
96protein localization to endoplasmic reticulum (GO:0070972)2.98756656
97transcription from RNA polymerase I promoter (GO:0006360)2.98726600
98telomere maintenance via telomere lengthening (GO:0010833)2.98354691
99CENP-A containing nucleosome assembly (GO:0034080)2.97505552
1007-methylguanosine mRNA capping (GO:0006370)2.97312450
101guanosine-containing compound biosynthetic process (GO:1901070)2.95742961
102regulation of translation in response to stress (GO:0043555)2.95626791
103establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95513055
104mitotic recombination (GO:0006312)2.94764550
105termination of RNA polymerase I transcription (GO:0006363)2.94533125
106regulation of ubiquitin-protein transferase activity (GO:0051438)2.92449497
107protein localization to mitochondrion (GO:0070585)2.91791005
108transcription-coupled nucleotide-excision repair (GO:0006283)2.90311710
109antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.90211593
110* cellular component biogenesis (GO:0044085)2.90117181
111energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89282098
112ATP synthesis coupled proton transport (GO:0015986)2.89282098
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88902394
114chromatin remodeling at centromere (GO:0031055)2.88763064
115proline biosynthetic process (GO:0006561)2.88341725
116regulation of translational termination (GO:0006449)2.88341691
117maturation of 5.8S rRNA (GO:0000460)2.87881960
118RNA capping (GO:0036260)2.86604800
1197-methylguanosine RNA capping (GO:0009452)2.86604800
120antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86184632
121transcription elongation from RNA polymerase I promoter (GO:0006362)2.84752947
122folic acid transport (GO:0015884)2.84689189
123pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84403890
124tRNA aminoacylation for protein translation (GO:0006418)2.83867105
125signal transduction in response to DNA damage (GO:0042770)2.83514273
126negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.82146456
127regulation of ligase activity (GO:0051340)2.80574056
128regulation of cell cycle arrest (GO:0071156)2.79409398
129pentose-phosphate shunt (GO:0006098)2.78207801
130NADPH regeneration (GO:0006740)2.78011459
131negative regulation of translational initiation (GO:0045947)2.76666834
132UTP biosynthetic process (GO:0006228)2.75876767
133lipopolysaccharide biosynthetic process (GO:0009103)2.75648103
134nucleobase-containing small molecule interconversion (GO:0015949)2.75326358
135positive regulation of cell cycle arrest (GO:0071158)2.75282567
136deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73303958
137amino acid activation (GO:0043038)2.73300727
138tRNA aminoacylation (GO:0043039)2.73300727
139nucleotide-sugar biosynthetic process (GO:0009226)2.71875799
140establishment of chromosome localization (GO:0051303)2.71847583
141de novo protein folding (GO:0006458)2.70870760
142pyrimidine nucleoside salvage (GO:0043097)2.70022819
143pyrimidine-containing compound salvage (GO:0008655)2.70022819
144GTP biosynthetic process (GO:0006183)2.69012352
145negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.68869325
146negative regulation of cell cycle G1/S phase transition (GO:1902807)2.68869325
147pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.66582815
148tRNA methylation (GO:0030488)2.65725763
149viral mRNA export from host cell nucleus (GO:0046784)2.64682932
150regulation of metalloenzyme activity (GO:0048552)2.64390147
151AMP metabolic process (GO:0046033)2.64088078
152pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.62654764
153de novo posttranslational protein folding (GO:0051084)2.61590994
154positive regulation of protein ubiquitination (GO:0031398)2.59350892
155tricarboxylic acid cycle (GO:0006099)2.58876428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.73667910
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11450442
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83832221
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09176382
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01552734
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.99794620
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.97868123
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.95226914
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91053052
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.87753695
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83336673
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77249788
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67309049
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59104059
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57199337
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40481653
17XRN2_22483619_ChIP-Seq_HELA_Human2.27448089
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23165596
19VDR_23849224_ChIP-Seq_CD4+_Human2.14433292
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04506570
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02557477
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01087175
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99262943
24AR_21909140_ChIP-Seq_LNCAP_Human1.95194885
25DCP1A_22483619_ChIP-Seq_HELA_Human1.94771065
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.92881461
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92743671
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91533517
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91329338
30* GABP_19822575_ChIP-Seq_HepG2_Human1.90083474
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86425319
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81199711
33FOXP3_21729870_ChIP-Seq_TREG_Human1.79198122
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79057576
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67867761
36TTF2_22483619_ChIP-Seq_HELA_Human1.67564055
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67320603
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66355066
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65687080
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59637862
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.56457285
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56155893
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55311470
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54374710
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50666588
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49917764
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48919549
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48479067
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.47676150
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.46965920
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.45670883
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44400714
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44355467
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43405390
55KDM5A_27292631_Chip-Seq_BREAST_Human1.42104360
56MYC_22102868_ChIP-Seq_BL_Human1.38459846
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.36600603
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32955567
59ELK1_19687146_ChIP-ChIP_HELA_Human1.32919619
60ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31905816
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31519034
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31120076
63CIITA_25753668_ChIP-Seq_RAJI_Human1.30961968
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30022669
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29872591
66ZNF263_19887448_ChIP-Seq_K562_Human1.25645490
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24854813
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22943627
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22647964
70* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21778059
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21594175
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21062678
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18357088
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17396872
75* ELK1_22589737_ChIP-Seq_MCF10A_Human1.16594089
76TFEB_21752829_ChIP-Seq_HELA_Human1.13806463
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13251812
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11344501
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09715843
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09631753
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.08753227
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07760994
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.07016781
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06436201
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06130918
86TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04179126
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04085014
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03795328
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.03317141
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01599307
91CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00665168
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00128609
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98724019
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98103532
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97966697
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97592118
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97475435
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97162810
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97028030
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96830396
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96479081
102VDR_21846776_ChIP-Seq_THP-1_Human0.95989990
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95218774
104* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94336682
105* ATF3_27146783_Chip-Seq_COLON_Human0.93826450
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92963127
107* SPI1_23547873_ChIP-Seq_NB4_Human0.92890304
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90790235
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89875844
110* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88865431
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.88524509
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88487525
113RACK7_27058665_Chip-Seq_MCF-7_Human0.88345550
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87381758
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87046694
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84751775
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83438522
118MYC_18940864_ChIP-ChIP_HL60_Human0.82788659
119* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82287825
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82013901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.54680464
2MP0004957_abnormal_blastocyst_morpholog4.11327782
3MP0003111_abnormal_nucleus_morphology3.95310251
4MP0010094_abnormal_chromosome_stability3.29910705
5* MP0003077_abnormal_cell_cycle3.25491045
6MP0003191_abnormal_cellular_cholesterol2.91970843
7MP0003718_maternal_effect2.76450343
8MP0003950_abnormal_plasma_membrane2.49925941
9MP0005360_urolithiasis2.49620375
10MP0009840_abnormal_foam_cell2.41834361
11MP0002877_abnormal_melanocyte_morpholog2.39945456
12MP0008058_abnormal_DNA_repair2.33496963
13MP0008007_abnormal_cellular_replicative2.31199123
14MP0008932_abnormal_embryonic_tissue2.29874907
15MP0010352_gastrointestinal_tract_polyps2.28063705
16MP0008057_abnormal_DNA_replication2.19488882
17MP0001730_embryonic_growth_arrest2.18329212
18MP0009697_abnormal_copulation2.17573349
19MP0003786_premature_aging1.97801116
20MP0005058_abnormal_lysosome_morphology1.95979601
21MP0009333_abnormal_splenocyte_physiolog1.93890365
22MP0000490_abnormal_crypts_of1.91459239
23MP0000350_abnormal_cell_proliferation1.88813095
24MP0004272_abnormal_basement_membrane1.84347040
25MP0010307_abnormal_tumor_latency1.81832455
26MP0006036_abnormal_mitochondrial_physio1.78348187
27MP0003806_abnormal_nucleotide_metabolis1.70137720
28MP0003123_paternal_imprinting1.68854433
29MP0005257_abnormal_intraocular_pressure1.65307972
30MP0002396_abnormal_hematopoietic_system1.63610847
31MP0003186_abnormal_redox_activity1.49648058
32MP0001672_abnormal_embryogenesis/_devel1.47740489
33MP0005380_embryogenesis_phenotype1.47740489
34MP0005408_hypopigmentation1.47630389
35MP0008438_abnormal_cutaneous_collagen1.45478386
36* MP0002080_prenatal_lethality1.40138777
37MP0001697_abnormal_embryo_size1.39786937
38MP0002019_abnormal_tumor_incidence1.38767077
39MP0005165_increased_susceptibility_to1.35948783
40MP0008875_abnormal_xenobiotic_pharmacok1.34364395
41MP0003705_abnormal_hypodermis_morpholog1.34126764
42MP0005397_hematopoietic_system_phenotyp1.33424639
43MP0001545_abnormal_hematopoietic_system1.33424639
44MP0000313_abnormal_cell_death1.32187126
45MP0003984_embryonic_growth_retardation1.29346126
46MP0002139_abnormal_hepatobiliary_system1.28427995
47MP0002088_abnormal_embryonic_growth/wei1.26351557
48MP0005330_cardiomyopathy1.25787879
49MP0005023_abnormal_wound_healing1.25629169
50MP0003941_abnormal_skin_development1.23504144
51MP0000858_altered_metastatic_potential1.22838871
52MP0003315_abnormal_perineum_morphology1.22772684
53MP0008260_abnormal_autophagy1.20076454
54MP0002132_abnormal_respiratory_system1.17554852
55MP0010030_abnormal_orbit_morphology1.14243884
56MP0002086_abnormal_extraembryonic_tissu1.14198562
57MP0001853_heart_inflammation1.13255009
58MP0005501_abnormal_skin_physiology1.11289990
59MP0002085_abnormal_embryonic_tissue1.10146585
60MP0000750_abnormal_muscle_regeneration1.08953286
61MP0006054_spinal_hemorrhage1.07728426
62MP0005451_abnormal_body_composition1.06296990
63MP0001661_extended_life_span1.05623759
64MP0005395_other_phenotype1.05057075
65MP0001881_abnormal_mammary_gland1.05035323
66MP0000358_abnormal_cell_content/1.04351470
67MP0005670_abnormal_white_adipose1.03925303
68MP0004808_abnormal_hematopoietic_stem1.02295855
69MP0010771_integument_phenotype1.01823723
70MP0003436_decreased_susceptibility_to1.00781752
71MP0001849_ear_inflammation0.98972501
72MP0002722_abnormal_immune_system0.98426109
73MP0003566_abnormal_cell_adhesion0.97359480
74MP0002796_impaired_skin_barrier0.96592556
75MP0000762_abnormal_tongue_morphology0.95409726
76MP0003567_abnormal_fetal_cardiomyocyte0.95160661
77MP0003763_abnormal_thymus_physiology0.95030368
78MP0004947_skin_inflammation0.94850626
79MP0000689_abnormal_spleen_morphology0.94369952
80MP0001542_abnormal_bone_strength0.93865526
81MP0008877_abnormal_DNA_methylation0.93819481
82MP0002084_abnormal_developmental_patter0.92711537
83MP0004197_abnormal_fetal_growth/weight/0.91363818
84MP0000477_abnormal_intestine_morphology0.88838143
85MP0003221_abnormal_cardiomyocyte_apopto0.88403706
86MP0000749_muscle_degeneration0.87994073
87MP0004233_abnormal_muscle_weight0.87488933
88MP0002398_abnormal_bone_marrow0.85420169
89MP0001216_abnormal_epidermal_layer0.84667287
90MP0010155_abnormal_intestine_physiology0.83749647
91MP0005332_abnormal_amino_acid0.83592230
92MP0009053_abnormal_anal_canal0.83366226
93MP0005076_abnormal_cell_differentiation0.83126011
94MP0000467_abnormal_esophagus_morphology0.83074970
95MP0003453_abnormal_keratinocyte_physiol0.82781303
96MP0005365_abnormal_bile_salt0.81099462
97MP0000343_altered_response_to0.80412026
98MP0005319_abnormal_enzyme/_coenzyme0.79127148
99MP0002429_abnormal_blood_cell0.79098841
100MP0000703_abnormal_thymus_morphology0.77748785
101MP0003075_altered_response_to0.77388108
102* MP0005621_abnormal_cell_physiology0.77251424
103MP0009785_altered_susceptibility_to0.76238239
104MP0002210_abnormal_sex_determination0.75094112
105* MP0005384_cellular_phenotype0.74337323
106MP0005083_abnormal_biliary_tract0.74156494
107MP0000678_abnormal_parathyroid_gland0.73899176
108MP0000627_abnormal_mammary_gland0.73862226
109MP0003448_altered_tumor_morphology0.73559165
110MP0005377_hearing/vestibular/ear_phenot0.73533916
111MP0003878_abnormal_ear_physiology0.73533916
112MP0004264_abnormal_extraembryonic_tissu0.73159451
113MP0001145_abnormal_male_reproductive0.72219833
114MP0000465_gastrointestinal_hemorrhage0.72210459
115MP0000537_abnormal_urethra_morphology0.71052635
116MP0005389_reproductive_system_phenotype0.70677475
117MP0000372_irregular_coat_pigmentation0.70094822
118MP0001666_abnormal_nutrient_absorption0.69579996
119MP0000685_abnormal_immune_system0.69220265
120MP0008873_increased_physiological_sensi0.68718014
121MP0005584_abnormal_enzyme/coenzyme_acti0.68646502
122MP0009278_abnormal_bone_marrow0.68417163
123MP0002405_respiratory_system_inflammati0.67861657
124MP0000716_abnormal_immune_system0.67075381
125MP0005197_abnormal_uvea_morphology0.66638046
126MP0010234_abnormal_vibrissa_follicle0.66534421
127MP0006035_abnormal_mitochondrial_morpho0.66058668
128MP0002111_abnormal_tail_morphology0.65945197
129MP0001727_abnormal_embryo_implantation0.65753484
130MP0003119_abnormal_digestive_system0.64405393
131MP0001119_abnormal_female_reproductive0.64208206
132MP0009931_abnormal_skin_appearance0.63954501
133MP0005464_abnormal_platelet_physiology0.63708371
134MP0001243_abnormal_dermal_layer0.63675104
135MP0002160_abnormal_reproductive_system0.63663276
136MP0002060_abnormal_skin_morphology0.63543292
137MP0003866_abnormal_defecation0.63228158
138MP0002452_abnormal_antigen_presenting0.63146914
139* MP0000609_abnormal_liver_physiology0.62814415
140* MP0000598_abnormal_liver_morphology0.62441755
141MP0001764_abnormal_homeostasis0.62196414
142MP0004782_abnormal_surfactant_physiolog0.61178860

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.50527701
2Birth length less than 3rd percentile (HP:0003561)4.46522638
3Rough bone trabeculation (HP:0100670)4.07123289
4Abnormality of cells of the erythroid lineage (HP:0012130)3.95622065
5Abnormality of glycolysis (HP:0004366)3.91053013
6Oral leukoplakia (HP:0002745)3.85256499
7Carpal bone hypoplasia (HP:0001498)3.84575599
8Abnormal number of erythroid precursors (HP:0012131)3.74350614
9Hepatocellular necrosis (HP:0001404)3.70733423
10Abnormal mitochondria in muscle tissue (HP:0008316)3.70456523
11Increased serum pyruvate (HP:0003542)3.69584150
12Reticulocytopenia (HP:0001896)3.65918317
13Type I transferrin isoform profile (HP:0003642)3.64130935
14Acute necrotizing encephalopathy (HP:0006965)3.61891103
15Acute encephalopathy (HP:0006846)3.56884433
16Cerebral hypomyelination (HP:0006808)3.56104298
17Multiple enchondromatosis (HP:0005701)3.52095390
18Trismus (HP:0000211)3.45482370
19Abnormal gallbladder physiology (HP:0012438)3.43981594
20Cholecystitis (HP:0001082)3.43981594
21Microretrognathia (HP:0000308)3.42312101
22Mitochondrial inheritance (HP:0001427)3.37319733
23Hepatic necrosis (HP:0002605)3.36733337
24Reduced antithrombin III activity (HP:0001976)3.36016831
25Premature ovarian failure (HP:0008209)3.27022378
26Increased CSF lactate (HP:0002490)3.26336765
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21765132
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21765132
29Secondary amenorrhea (HP:0000869)3.20192762
30Macrocytic anemia (HP:0001972)3.19087101
31Microvesicular hepatic steatosis (HP:0001414)3.15036155
32Abnormality of the anterior horn cell (HP:0006802)3.05784951
33Degeneration of anterior horn cells (HP:0002398)3.05784951
34Abnormal trabecular bone morphology (HP:0100671)2.96843720
35Patellar aplasia (HP:0006443)2.90859298
36Aplasia/Hypoplasia of the patella (HP:0006498)2.88722456
37Selective tooth agenesis (HP:0001592)2.88394322
38Abnormal protein glycosylation (HP:0012346)2.87939776
39Abnormal glycosylation (HP:0012345)2.87939776
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.87939776
41Abnormal protein N-linked glycosylation (HP:0012347)2.87939776
42Progressive muscle weakness (HP:0003323)2.76833255
43Pustule (HP:0200039)2.72599638
44Vertebral compression fractures (HP:0002953)2.71512647
45Entropion (HP:0000621)2.71494576
46Cerebral edema (HP:0002181)2.70908567
47Progressive macrocephaly (HP:0004481)2.70483447
48Pallor (HP:0000980)2.68063175
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.67001858
50Sparse eyelashes (HP:0000653)2.66885070
51Lactic acidosis (HP:0003128)2.62710592
52Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.62029010
53Hypokinesia (HP:0002375)2.61640136
54Exercise intolerance (HP:0003546)2.59494044
55Increased hepatocellular lipid droplets (HP:0006565)2.59225912
56Renal Fanconi syndrome (HP:0001994)2.51106171
57Abnormality of the umbilical cord (HP:0010881)2.49243625
58Neoplasm of the pancreas (HP:0002894)2.44121040
59Increased intramyocellular lipid droplets (HP:0012240)2.43490383
60Ragged-red muscle fibers (HP:0003200)2.41336032
61Abnormality of methionine metabolism (HP:0010901)2.40033536
62Abnormality of placental membranes (HP:0011409)2.38965480
63Amniotic constriction ring (HP:0009775)2.38965480
64Lipid accumulation in hepatocytes (HP:0006561)2.38065307
65Colon cancer (HP:0003003)2.36863199
66Aplastic anemia (HP:0001915)2.35320081
67Testicular atrophy (HP:0000029)2.33811412
68Respiratory failure (HP:0002878)2.31197441
69Congenital ichthyosiform erythroderma (HP:0007431)2.31068514
70Megaloblastic anemia (HP:0001889)2.31046550
71Impulsivity (HP:0100710)2.30409654
72Absent radius (HP:0003974)2.28957775
73Premature graying of hair (HP:0002216)2.26254256
74Personality changes (HP:0000751)2.22964795
75Abnormality of the distal phalanges of the toes (HP:0010182)2.22512881
76Cellular immunodeficiency (HP:0005374)2.19219231
77Nausea (HP:0002018)2.18301895
78Ureteral duplication (HP:0000073)2.17617857
79Glucose intolerance (HP:0000833)2.17339649
80Increased muscle lipid content (HP:0009058)2.16490014
81Opisthotonus (HP:0002179)2.14403335
82Spastic paraparesis (HP:0002313)2.14079627
83Absent thumb (HP:0009777)2.12726822
84Aplasia involving forearm bones (HP:0009822)2.10832626
85Absent forearm bone (HP:0003953)2.10832626
86Onycholysis (HP:0001806)2.10361231
87Glossoptosis (HP:0000162)2.09942761
88Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09081404
89Abnormality of the preputium (HP:0100587)2.08825926
90Death in infancy (HP:0001522)2.08168572
91Prolonged neonatal jaundice (HP:0006579)2.05177102
92Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03149631
93CNS hypomyelination (HP:0003429)1.99804712
94Horseshoe kidney (HP:0000085)1.97756427
95Emotional lability (HP:0000712)1.96417399
96Cleft eyelid (HP:0000625)1.93982856
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93981122
98Hyperalaninemia (HP:0003348)1.93489244
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93489244
100Abnormality of alanine metabolism (HP:0010916)1.93489244
101Upper limb muscle weakness (HP:0003484)1.93220288
102Distal lower limb muscle weakness (HP:0009053)1.92119615
103Thrombocytosis (HP:0001894)1.91919758
104Squamous cell carcinoma (HP:0002860)1.91320881
105Abnormalities of placenta or umbilical cord (HP:0001194)1.90458684
106Lethargy (HP:0001254)1.89264353
107Bone marrow hypocellularity (HP:0005528)1.88729506
108Meckel diverticulum (HP:0002245)1.87649814
109Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87571110
110Generalized amyotrophy (HP:0003700)1.87357774
111Poor head control (HP:0002421)1.86602954
112Premature rupture of membranes (HP:0001788)1.85746073
113Dicarboxylic aciduria (HP:0003215)1.84442968
114Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84442968
115Osteolytic defects of the hand bones (HP:0009699)1.84289445
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.84289445
117Hepatosplenomegaly (HP:0001433)1.84158734
118Abnormal hair laboratory examination (HP:0003328)1.82305835
119Atrophy/Degeneration involving motor neurons (HP:0007373)1.81970112
120Petechiae (HP:0000967)1.81470683
121Respiratory difficulties (HP:0002880)1.80976625
122Gout (HP:0001997)1.80651405
123Rhabdomyolysis (HP:0003201)1.79589535
124Abnormality of pyrimidine metabolism (HP:0004353)1.79401477
125Nail dystrophy (HP:0008404)1.79388237
126Aplasia/hypoplasia of the humerus (HP:0006507)1.79297651
12711 pairs of ribs (HP:0000878)1.78312851
128Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78278194
129Chromsome breakage (HP:0040012)1.76755519
130Irregular epiphyses (HP:0010582)1.76215374
131Hyperammonemia (HP:0001987)1.76174009
132Sparse lateral eyebrow (HP:0005338)1.74589199
133Methylmalonic aciduria (HP:0012120)1.74478300
134Tracheoesophageal fistula (HP:0002575)1.73064757
135Hypobetalipoproteinemia (HP:0003563)1.72727319
136Alopecia of scalp (HP:0002293)1.72324826
137Abnormal spermatogenesis (HP:0008669)1.71978461
138Abnormal umbilical cord blood vessels (HP:0011403)1.71808974
139Single umbilical artery (HP:0001195)1.71808974
140Abnormality of the fetal cardiovascular system (HP:0010948)1.71808974
141Fasciculations (HP:0002380)1.71390919
142Increased serum lactate (HP:0002151)1.71222767
143Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71058374
144Abnormal cartilage morphology (HP:0002763)1.70367628
145Poikiloderma (HP:0001029)1.70069390
146Abnormality of reticulocytes (HP:0004312)1.69998085
147Abnormality of the ileum (HP:0001549)1.69742587
148Abnormality of the calcaneus (HP:0008364)1.68609438
149Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68321115
150Agnosia (HP:0010524)1.67666327
151Breech presentation (HP:0001623)1.66860788
152Slender long bone (HP:0003100)1.64774481
153Congenital, generalized hypertrichosis (HP:0004540)1.64598476
154Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.64304430
155Areflexia of lower limbs (HP:0002522)1.64198407
156Hyperglycinemia (HP:0002154)1.64074274
157Pancytopenia (HP:0001876)1.62808333
158Reduced subcutaneous adipose tissue (HP:0003758)1.62322207
159Muscle fiber atrophy (HP:0100295)1.61521146
160Stillbirth (HP:0003826)1.59815474
161Myelodysplasia (HP:0002863)1.59082289
162CNS demyelination (HP:0007305)1.58996764
163Short nail (HP:0001799)1.58466855
164Tongue fasciculations (HP:0001308)1.58337103
165Abnormality of chromosome stability (HP:0003220)1.57869981
166Small intestinal stenosis (HP:0012848)1.57143284
167Duodenal stenosis (HP:0100867)1.57143284
168Basal cell carcinoma (HP:0002671)1.56325260

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.56555901
2VRK24.47574443
3WEE13.62802390
4EIF2AK13.38065177
5NME23.13374802
6EPHA23.10595602
7TESK22.54197037
8PLK42.52512217
9NEK22.32414260
10PIM22.24875812
11STK162.23755386
12TSSK62.21893441
13TTK2.07483280
14CDC72.06415917
15MAP3K121.99554870
16RPS6KA41.84713364
17LMTK21.76031715
18PDK21.73050267
19EIF2AK31.67268588
20SMG11.65163918
21SRPK11.63878284
22PLK11.62077149
23RPS6KB21.60927066
24ACVR1B1.60855987
25BRSK21.60763466
26IRAK31.58570704
27KDR1.56468019
28NEK11.56151164
29TLK11.47659450
30AURKB1.44702543
31MAP3K81.40565718
32DYRK31.40384237
33PAK41.35990943
34DAPK11.32563281
35MET1.31934691
36ZAK1.31282489
37CDK71.29750829
38STK101.27635579
39TESK11.25781138
40MAPKAPK31.24984738
41VRK11.21278290
42AURKA1.21069009
43MAP3K111.16472327
44PLK31.12006955
45EEF2K1.11683204
46TRIM281.10961093
47NME11.09680375
48BRAF1.08613040
49ERBB41.08503579
50ARAF1.05863748
51MAP3K31.04931978
52BRSK11.04212858
53LRRK21.02963150
54MYLK1.02156559
55MAP4K11.01486889
56CHEK20.99330365
57PIM10.96502345
58CDK40.93096880
59ATR0.91897422
60BLK0.90654190
61LATS20.90430869
62PTK20.89675325
63MAP2K20.88836928
64PAK10.85279323
65ERN10.81314498
66BCKDK0.81305776
67ABL20.79725985
68PASK0.79361615
69PRKCI0.75762895
70SCYL20.74295078
71SIK30.73010954
72TGFBR10.72810217
73CHEK10.72674748
74CSNK1G30.72503127
75TRIB30.71481049
76MST40.71032825
77MKNK10.70704289
78STK38L0.70539849
79AKT30.68053705
80ALK0.67104753
81DAPK30.66942111
82PBK0.64349065
83MAP2K30.63506584
84ZAP700.60950294
85TYK20.60581295
86STK40.60225886
87STK30.58510204
88FLT30.57644531
89CSNK2A10.55848924
90CSNK1A1L0.55101874
91CSNK2A20.53729425
92EIF2AK20.53499418
93TAF10.52328939
94RPS6KA50.51994420
95MOS0.50232945
96MST1R0.50112732
97MAP3K100.49659871
98CDK20.48978578
99CCNB10.48413994
100CLK10.47966564
101LIMK10.47918313
102IKBKB0.46290314
103TBK10.42146831
104CSNK1G10.41868763
105BMX0.41118052
106MKNK20.40755930
107NEK90.40060915
108NUAK10.38248540
109DYRK20.37815590
110RAF10.37526923
111GRK60.36279930
112CDK90.36125889
113ATM0.35975690
114CDK80.35224722
115JAK30.34995347
116TAOK10.34935643
117PKN20.34670596
118AKT20.34407297
119MELK0.33890133
120PRKG20.33820388
121CDK120.33050865
122FER0.32175410
123ICK0.31981144
124ILK0.31956618
125MAPKAPK20.31847743
126MAP4K20.31392092
127IRAK40.29914066
128TAOK20.29466596
129CAMK2G0.26473392
130CSNK1G20.25938877
131CDK140.25465421
132CDK180.22839775
133EPHB20.22818695

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.30196600
2DNA replication_Homo sapiens_hsa030303.93616998
3Ribosome_Homo sapiens_hsa030103.73888216
4* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.69754956
5RNA polymerase_Homo sapiens_hsa030203.68188056
6Mismatch repair_Homo sapiens_hsa034303.03260067
7RNA transport_Homo sapiens_hsa030132.87623999
8Spliceosome_Homo sapiens_hsa030402.70758267
9Pyrimidine metabolism_Homo sapiens_hsa002402.62967841
10Base excision repair_Homo sapiens_hsa034102.53650666
11Nucleotide excision repair_Homo sapiens_hsa034202.29283750
12Homologous recombination_Homo sapiens_hsa034402.22928029
13Cell cycle_Homo sapiens_hsa041102.16099510
14One carbon pool by folate_Homo sapiens_hsa006702.14011343
15Vitamin B6 metabolism_Homo sapiens_hsa007502.13446008
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08623864
17Fatty acid elongation_Homo sapiens_hsa000622.04529679
18Folate biosynthesis_Homo sapiens_hsa007901.99938553
19p53 signaling pathway_Homo sapiens_hsa041151.73349293
20Pentose phosphate pathway_Homo sapiens_hsa000301.62320942
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60870697
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58490201
23Basal transcription factors_Homo sapiens_hsa030221.49956951
24Sulfur metabolism_Homo sapiens_hsa009201.44340651
25Pyruvate metabolism_Homo sapiens_hsa006201.42912043
26Sulfur relay system_Homo sapiens_hsa041221.39771260
27RNA degradation_Homo sapiens_hsa030181.36584307
28Fanconi anemia pathway_Homo sapiens_hsa034601.36572663
29Purine metabolism_Homo sapiens_hsa002301.33295019
30Epstein-Barr virus infection_Homo sapiens_hsa051691.25323406
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24023350
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.19710135
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.19335683
34Alzheimers disease_Homo sapiens_hsa050101.18317403
35Biosynthesis of amino acids_Homo sapiens_hsa012301.17743207
36Non-homologous end-joining_Homo sapiens_hsa034501.09280106
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01420232
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00218344
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.96770838
40Antigen processing and presentation_Homo sapiens_hsa046120.93865209
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92346462
42Fructose and mannose metabolism_Homo sapiens_hsa000510.92197880
43Glutathione metabolism_Homo sapiens_hsa004800.92024132
44mRNA surveillance pathway_Homo sapiens_hsa030150.91860845
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91020359
46Vibrio cholerae infection_Homo sapiens_hsa051100.90687421
47Selenocompound metabolism_Homo sapiens_hsa004500.90532940
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82606055
49Legionellosis_Homo sapiens_hsa051340.82248685
50Systemic lupus erythematosus_Homo sapiens_hsa053220.80597480
51Viral carcinogenesis_Homo sapiens_hsa052030.78557911
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77703249
53Herpes simplex infection_Homo sapiens_hsa051680.76683034
54Carbon metabolism_Homo sapiens_hsa012000.75047500
55Phenylalanine metabolism_Homo sapiens_hsa003600.73898508
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72475218
57Steroid biosynthesis_Homo sapiens_hsa001000.71340623
58Arginine biosynthesis_Homo sapiens_hsa002200.69215150
59Vitamin digestion and absorption_Homo sapiens_hsa049770.68069263
60Propanoate metabolism_Homo sapiens_hsa006400.67267002
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66712098
62Tyrosine metabolism_Homo sapiens_hsa003500.65765743
63Regulation of autophagy_Homo sapiens_hsa041400.65493950
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63779036
65Apoptosis_Homo sapiens_hsa042100.63457318
66Galactose metabolism_Homo sapiens_hsa000520.59149917
67Peroxisome_Homo sapiens_hsa041460.56602581
68Shigellosis_Homo sapiens_hsa051310.52543419
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.51004852
70Small cell lung cancer_Homo sapiens_hsa052220.50796710
71HTLV-I infection_Homo sapiens_hsa051660.50541571
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49639627
73Huntingtons disease_Homo sapiens_hsa050160.49439414
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49318646
75Fatty acid metabolism_Homo sapiens_hsa012120.49117952
76Bladder cancer_Homo sapiens_hsa052190.49035949
77Protein export_Homo sapiens_hsa030600.48047701
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47628548
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46465363
80Thyroid cancer_Homo sapiens_hsa052160.45621721
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.43761636
82Arginine and proline metabolism_Homo sapiens_hsa003300.43669744
83Oocyte meiosis_Homo sapiens_hsa041140.43489181
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.42113090
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41582252
86Metabolic pathways_Homo sapiens_hsa011000.40748252
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.38966296
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38409748
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37616513
90Fat digestion and absorption_Homo sapiens_hsa049750.36947969
91Renin-angiotensin system_Homo sapiens_hsa046140.36370191
92Chemical carcinogenesis_Homo sapiens_hsa052040.36293242
93Fatty acid degradation_Homo sapiens_hsa000710.36211128
94Measles_Homo sapiens_hsa051620.35527059
95Arachidonic acid metabolism_Homo sapiens_hsa005900.35324028
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.35169395
97Primary immunodeficiency_Homo sapiens_hsa053400.33178904
98Parkinsons disease_Homo sapiens_hsa050120.32951778
99Lysosome_Homo sapiens_hsa041420.31464041
100HIF-1 signaling pathway_Homo sapiens_hsa040660.29564259
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29521011
102Influenza A_Homo sapiens_hsa051640.29141155
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28280788
104Linoleic acid metabolism_Homo sapiens_hsa005910.27240588
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27139446
106Starch and sucrose metabolism_Homo sapiens_hsa005000.27067696
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26546557
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.25257281
109MicroRNAs in cancer_Homo sapiens_hsa052060.24878409
110N-Glycan biosynthesis_Homo sapiens_hsa005100.24550903
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24186025
112Salmonella infection_Homo sapiens_hsa051320.22785577
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22336275
114Hepatitis B_Homo sapiens_hsa051610.22242176
115Other glycan degradation_Homo sapiens_hsa005110.21728372
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21387950
117Leishmaniasis_Homo sapiens_hsa051400.20954258
118Oxidative phosphorylation_Homo sapiens_hsa001900.20399417
119Complement and coagulation cascades_Homo sapiens_hsa046100.19494419
120Sphingolipid metabolism_Homo sapiens_hsa006000.18769626
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17208186
122beta-Alanine metabolism_Homo sapiens_hsa004100.17082334
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16190642
124Hippo signaling pathway_Homo sapiens_hsa043900.15467625
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15069049
126Hematopoietic cell lineage_Homo sapiens_hsa046400.14863858
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14509639
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14035249
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12183141
130Acute myeloid leukemia_Homo sapiens_hsa052210.12088089
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11828362

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