EIF5AL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.90055323
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.53652941
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.28678789
4ATP synthesis coupled proton transport (GO:0015986)5.28678789
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.98822266
6protein complex biogenesis (GO:0070271)4.77355272
7water-soluble vitamin biosynthetic process (GO:0042364)4.70388979
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.70319620
9chaperone-mediated protein transport (GO:0072321)4.63826936
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.57060604
11termination of RNA polymerase III transcription (GO:0006386)4.57060604
12mitochondrial respiratory chain complex assembly (GO:0033108)4.48690757
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.42285436
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.42285436
15NADH dehydrogenase complex assembly (GO:0010257)4.42285436
16respiratory electron transport chain (GO:0022904)4.30856813
17electron transport chain (GO:0022900)4.30804927
18behavioral response to nicotine (GO:0035095)4.01424829
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.98419119
20maturation of SSU-rRNA (GO:0030490)3.94226904
21proteasome assembly (GO:0043248)3.85736654
22protein-cofactor linkage (GO:0018065)3.80361848
23regulation of mitochondrial translation (GO:0070129)3.67341736
24pseudouridine synthesis (GO:0001522)3.66085924
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.63004222
26platelet dense granule organization (GO:0060155)3.60004731
27cullin deneddylation (GO:0010388)3.57031595
28protein neddylation (GO:0045116)3.55087066
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53956933
30protein deneddylation (GO:0000338)3.45266949
31cytochrome complex assembly (GO:0017004)3.44903707
32cytidine deamination (GO:0009972)3.44644363
33cytidine metabolic process (GO:0046087)3.44644363
34cytidine catabolic process (GO:0006216)3.44644363
35respiratory chain complex IV assembly (GO:0008535)3.43679816
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.39974286
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.39974286
38mannosylation (GO:0097502)3.37957762
39viral transcription (GO:0019083)3.34270244
40ribosomal small subunit biogenesis (GO:0042274)3.32467706
41translational termination (GO:0006415)3.32086286
42negative regulation of T cell differentiation in thymus (GO:0033085)3.28871919
43ribosomal small subunit assembly (GO:0000028)3.26695864
44base-excision repair, AP site formation (GO:0006285)3.16581717
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15371062
46cotranslational protein targeting to membrane (GO:0006613)3.13197577
47protein targeting to ER (GO:0045047)3.11989281
48rRNA modification (GO:0000154)3.11552561
49hydrogen ion transmembrane transport (GO:1902600)3.08984107
50ribosomal large subunit biogenesis (GO:0042273)3.08274174
51protein targeting to mitochondrion (GO:0006626)3.05522761
52translation (GO:0006412)3.04596836
53tRNA processing (GO:0008033)3.03911920
54purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99906998
55GTP biosynthetic process (GO:0006183)2.99116757
56establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97855956
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96735018
58preassembly of GPI anchor in ER membrane (GO:0016254)2.95830182
59establishment of protein localization to mitochondrion (GO:0072655)2.95687256
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94742222
61proton transport (GO:0015992)2.93962577
62protein localization to endoplasmic reticulum (GO:0070972)2.93674391
63ATP biosynthetic process (GO:0006754)2.93360791
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92413288
65* translational elongation (GO:0006414)2.90597719
66negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.90546615
67intracellular protein transmembrane import (GO:0044743)2.89365078
68hydrogen transport (GO:0006818)2.88427938
69cellular component biogenesis (GO:0044085)2.87622158
70rRNA processing (GO:0006364)2.85921115
71regulation of cellular amino acid metabolic process (GO:0006521)2.83762008
72rRNA metabolic process (GO:0016072)2.82718405
73pyrimidine ribonucleoside catabolic process (GO:0046133)2.82330521
74protein localization to mitochondrion (GO:0070585)2.81795337
75negative regulation of telomere maintenance (GO:0032205)2.78002931
76response to pheromone (GO:0019236)2.76801305
77L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75362604
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74895053
79protein K6-linked ubiquitination (GO:0085020)2.74583287
80DNA replication checkpoint (GO:0000076)2.70693709
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70444174
82DNA catabolic process, exonucleolytic (GO:0000738)2.68262509
83negative regulation of ligase activity (GO:0051352)2.68049135
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68049135
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67091847
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67091847
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67091847
88iron-sulfur cluster assembly (GO:0016226)2.66164372
89metallo-sulfur cluster assembly (GO:0031163)2.66164372
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65939178
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61957110
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61957110
93dopamine transport (GO:0015872)2.60853883
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59548975
95GPI anchor metabolic process (GO:0006505)2.56171409
96viral life cycle (GO:0019058)2.55694103
97positive regulation of prostaglandin secretion (GO:0032308)2.55276414
98maturation of 5.8S rRNA (GO:0000460)2.54068554
99rRNA methylation (GO:0031167)2.53428983
100signal transduction involved in cell cycle checkpoint (GO:0072395)2.52980332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.35996225
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.28691496
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.92544778
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.55557978
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.48046309
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.47466607
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.05008425
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03784801
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.02397989
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78429420
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76400368
12VDR_23849224_ChIP-Seq_CD4+_Human2.74828422
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59339910
14ZNF274_21170338_ChIP-Seq_K562_Hela2.49534242
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45894184
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44327202
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.40996227
18VDR_22108803_ChIP-Seq_LS180_Human2.40729073
19ELK1_19687146_ChIP-ChIP_HELA_Human2.35471076
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.28726634
21MYC_18940864_ChIP-ChIP_HL60_Human2.24518537
22FOXP3_21729870_ChIP-Seq_TREG_Human2.18104794
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00542369
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.00016707
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93163411
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74100672
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66330428
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.61564271
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59577794
30EWS_26573619_Chip-Seq_HEK293_Human1.59011960
31GABP_19822575_ChIP-Seq_HepG2_Human1.56123909
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55385623
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53692435
34TTF2_22483619_ChIP-Seq_HELA_Human1.53085326
35FUS_26573619_Chip-Seq_HEK293_Human1.45074028
36DCP1A_22483619_ChIP-Seq_HELA_Human1.44515527
37TP53_22573176_ChIP-Seq_HFKS_Human1.43403676
38ELK1_22589737_ChIP-Seq_MCF10A_Human1.38852938
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37518886
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37195139
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36318479
42XRN2_22483619_ChIP-Seq_HELA_Human1.34890004
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.33465919
44AR_20517297_ChIP-Seq_VCAP_Human1.32924560
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.32101311
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32101311
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31702334
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30918142
49IGF1R_20145208_ChIP-Seq_DFB_Human1.30632634
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30519008
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29159634
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25859849
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24724437
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24209367
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23628927
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20829794
57IRF1_19129219_ChIP-ChIP_H3396_Human1.20385125
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18593811
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18211562
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16238062
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13264966
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10486630
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.10241536
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07946153
65NCOR_22424771_ChIP-Seq_293T_Human1.06519579
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05252579
67TAF2_19829295_ChIP-Seq_ESCs_Human1.04447018
68NANOG_19829295_ChIP-Seq_ESCs_Human1.04408789
69SOX2_19829295_ChIP-Seq_ESCs_Human1.04408789
70NANOG_20526341_ChIP-Seq_ESCs_Human1.04203120
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04066451
72P300_19829295_ChIP-Seq_ESCs_Human1.03721678
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02545641
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.01517720
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01175699
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00976045
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98762695
78ERG_20517297_ChIP-Seq_VCAP_Human0.98701307
79MYC_19829295_ChIP-Seq_ESCs_Human0.97130704
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97019295
81PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95065304
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94097523
83* GATA3_26560356_Chip-Seq_TH2_Human0.93986766
84MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92805286
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92427594
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91669449
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91632580
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91450381
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91144242
90P53_21459846_ChIP-Seq_SAOS-2_Human0.90954330
91CBP_20019798_ChIP-Seq_JUKART_Human0.90785248
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90785248
93ERA_21632823_ChIP-Seq_H3396_Human0.88832022
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88392416
95TAF15_26573619_Chip-Seq_HEK293_Human0.87723706
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86697805
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86558436
98EZH2_22144423_ChIP-Seq_EOC_Human0.86546565
99* HOXB7_26014856_ChIP-Seq_BT474_Human0.86340422
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86288013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis2.96385882
2MP0009379_abnormal_foot_pigmentation2.62423743
3MP0006072_abnormal_retinal_apoptosis2.56390136
4MP0006292_abnormal_olfactory_placode2.54433757
5MP0002653_abnormal_ependyma_morphology2.41404897
6MP0002102_abnormal_ear_morphology2.39616716
7MP0008877_abnormal_DNA_methylation2.37365113
8MP0008872_abnormal_physiological_respon2.16075839
9MP0002736_abnormal_nociception_after2.14359104
10MP0002138_abnormal_hepatobiliary_system2.14288933
11MP0003195_calcinosis2.04526606
12MP0003786_premature_aging2.03369955
13MP0008875_abnormal_xenobiotic_pharmacok2.01996522
14MP0001968_abnormal_touch/_nociception2.01788568
15MP0002277_abnormal_respiratory_mucosa2.00921306
16MP0005671_abnormal_response_to1.96311090
17MP0003011_delayed_dark_adaptation1.95302844
18MP0002163_abnormal_gland_morphology1.94413872
19MP0008058_abnormal_DNA_repair1.91565076
20MP0000372_irregular_coat_pigmentation1.90100505
21MP0002876_abnormal_thyroid_physiology1.87703197
22MP0005389_reproductive_system_phenotype1.87018254
23MP0005646_abnormal_pituitary_gland1.86486020
24MP0003806_abnormal_nucleotide_metabolis1.83986875
25MP0002160_abnormal_reproductive_system1.82131800
26MP0005084_abnormal_gallbladder_morpholo1.76383050
27MP0001905_abnormal_dopamine_level1.75883882
28MP0004142_abnormal_muscle_tone1.70614176
29MP0005551_abnormal_eye_electrophysiolog1.68208575
30MP0004147_increased_porphyrin_level1.64886939
31MP0001919_abnormal_reproductive_system1.64377157
32MP0003718_maternal_effect1.63234334
33MP0006036_abnormal_mitochondrial_physio1.60287150
34MP0009046_muscle_twitch1.54853068
35MP0005379_endocrine/exocrine_gland_phen1.51846010
36MP0005253_abnormal_eye_physiology1.45200786
37MP0004885_abnormal_endolymph1.43450125
38MP0005645_abnormal_hypothalamus_physiol1.41764895
39MP0001188_hyperpigmentation1.40795462
40MP0002938_white_spotting1.40763192
41MP0002234_abnormal_pharynx_morphology1.37124235
42MP0001764_abnormal_homeostasis1.35571999
43MP0003693_abnormal_embryo_hatching1.32872257
44MP0000631_abnormal_neuroendocrine_gland1.28226604
45MP0005410_abnormal_fertilization1.25391626
46MP0009745_abnormal_behavioral_response1.24259292
47MP0005075_abnormal_melanosome_morpholog1.23572309
48MP0002272_abnormal_nervous_system1.21806132
49MP0002095_abnormal_skin_pigmentation1.20706087
50MP0003646_muscle_fatigue1.19440773
51MP0002638_abnormal_pupillary_reflex1.16026684
52MP0003186_abnormal_redox_activity1.14523020
53MP0004043_abnormal_pH_regulation1.13925616
54MP0001986_abnormal_taste_sensitivity1.13614176
55MP0003315_abnormal_perineum_morphology1.09990894
56MP0005332_abnormal_amino_acid1.08832057
57MP0005174_abnormal_tail_pigmentation1.07621621
58MP0006276_abnormal_autonomic_nervous1.05950192
59MP0003283_abnormal_digestive_organ1.01752920
60MP0008007_abnormal_cellular_replicative1.00752266
61MP0004145_abnormal_muscle_electrophysio0.98060058
62MP0000685_abnormal_immune_system0.96564109
63MP0001485_abnormal_pinna_reflex0.94626199
64MP0009333_abnormal_splenocyte_physiolog0.93973934
65MP0003567_abnormal_fetal_cardiomyocyte0.92397470
66MP0002210_abnormal_sex_determination0.92076798
67MP0002693_abnormal_pancreas_physiology0.89265151
68MP0003787_abnormal_imprinting0.88839760
69MP0004133_heterotaxia0.88471126
70MP0005636_abnormal_mineral_homeostasis0.87351051
71MP0001529_abnormal_vocalization0.85959388
72MP0001984_abnormal_olfaction0.85646875
73MP0003119_abnormal_digestive_system0.85607465
74MP0008775_abnormal_heart_ventricle0.82962259
75MP0000049_abnormal_middle_ear0.82940434
76MP0006035_abnormal_mitochondrial_morpho0.82844567
77MP0001293_anophthalmia0.82840446
78MP0004742_abnormal_vestibular_system0.82473382
79MP0001873_stomach_inflammation0.82024229
80MP0001929_abnormal_gametogenesis0.80986128
81MP0005367_renal/urinary_system_phenotyp0.80764464
82MP0000516_abnormal_urinary_system0.80764464
83MP0001501_abnormal_sleep_pattern0.80082961
84MP0009785_altered_susceptibility_to0.79469026
85MP0003880_abnormal_central_pattern0.78176410
86MP0000653_abnormal_sex_gland0.77183217
87MP0010094_abnormal_chromosome_stability0.77066506
88MP0000427_abnormal_hair_cycle0.75999936
89MP0001145_abnormal_male_reproductive0.75705263
90MP0009697_abnormal_copulation0.75563821
91MP0001756_abnormal_urination0.75426577
92MP0002148_abnormal_hypersensitivity_rea0.74023447
93MP0008995_early_reproductive_senescence0.72847819
94MP0000230_abnormal_systemic_arterial0.70310987
95MP0005195_abnormal_posterior_eye0.69844938
96MP0008789_abnormal_olfactory_epithelium0.69473059
97MP0002733_abnormal_thermal_nociception0.68893519
98MP0005377_hearing/vestibular/ear_phenot0.68244075
99MP0003878_abnormal_ear_physiology0.68244075
100MP0004215_abnormal_myocardial_fiber0.67262674

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.73671475
2Mitochondrial inheritance (HP:0001427)4.43097403
3Abnormal mitochondria in muscle tissue (HP:0008316)4.25384726
4Progressive macrocephaly (HP:0004481)4.08278672
5Increased CSF lactate (HP:0002490)4.01652898
6Acute encephalopathy (HP:0006846)3.96995753
7Hepatocellular necrosis (HP:0001404)3.66526320
8Pancreatic cysts (HP:0001737)3.56513905
9Increased hepatocellular lipid droplets (HP:0006565)3.48720959
103-Methylglutaconic aciduria (HP:0003535)3.45741694
11Hepatic necrosis (HP:0002605)3.41040930
12Congenital, generalized hypertrichosis (HP:0004540)3.37684552
13Abnormal number of erythroid precursors (HP:0012131)3.36889907
14Lipid accumulation in hepatocytes (HP:0006561)3.26070667
15Molar tooth sign on MRI (HP:0002419)3.13909322
16Abnormality of midbrain morphology (HP:0002418)3.13909322
17Methylmalonic acidemia (HP:0002912)3.12637553
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10081329
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10081329
20Congenital stationary night blindness (HP:0007642)3.05775799
21Pancreatic fibrosis (HP:0100732)3.05119890
22Methylmalonic aciduria (HP:0012120)3.00047971
23Abnormality of cells of the erythroid lineage (HP:0012130)2.93375704
24Renal Fanconi syndrome (HP:0001994)2.92062272
25Cerebral edema (HP:0002181)2.90107281
26Increased serum lactate (HP:0002151)2.79246427
27Lactic acidosis (HP:0003128)2.72485365
28True hermaphroditism (HP:0010459)2.69860800
29Type I transferrin isoform profile (HP:0003642)2.63513219
30Exertional dyspnea (HP:0002875)2.59768244
31Optic disc pallor (HP:0000543)2.55069122
32Increased intramyocellular lipid droplets (HP:0012240)2.54744152
33Nephronophthisis (HP:0000090)2.44271364
34Pendular nystagmus (HP:0012043)2.41531411
35Type II lissencephaly (HP:0007260)2.41382354
36Abnormality of alanine metabolism (HP:0010916)2.41313300
37Hyperalaninemia (HP:0003348)2.41313300
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41313300
39Aplastic anemia (HP:0001915)2.41308394
40Respiratory failure (HP:0002878)2.40580581
41Macrocytic anemia (HP:0001972)2.39282438
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38447394
43Chronic hepatic failure (HP:0100626)2.38000834
44Sclerocornea (HP:0000647)2.37025833
45IgG deficiency (HP:0004315)2.33479700
46Abnormality of the renal cortex (HP:0011035)2.31224321
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31217817
48Abnormal protein N-linked glycosylation (HP:0012347)2.31217817
49Abnormal protein glycosylation (HP:0012346)2.31217817
50Abnormal glycosylation (HP:0012345)2.31217817
51Renal cortical cysts (HP:0000803)2.29728229
52Aplasia/hypoplasia of the uterus (HP:0008684)2.29673862
53Lethargy (HP:0001254)2.28988504
54Delayed CNS myelination (HP:0002188)2.23253087
55Abnormality of renal resorption (HP:0011038)2.20368106
56Reticulocytopenia (HP:0001896)2.18982807
57Abolished electroretinogram (ERG) (HP:0000550)2.15984101
58Exercise intolerance (HP:0003546)2.15343946
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12388335
60Increased muscle lipid content (HP:0009058)2.12004157
61Medial flaring of the eyebrow (HP:0010747)2.09721583
62Pancytopenia (HP:0001876)2.08881418
63Glycosuria (HP:0003076)2.08473409
64Abnormality of urine glucose concentration (HP:0011016)2.08473409
65Abnormality of the renal medulla (HP:0100957)2.06610113
66Abnormality of the pons (HP:0007361)2.03574820
67Abnormal rod and cone electroretinograms (HP:0008323)2.02066021
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01815052
69Hypoplasia of the pons (HP:0012110)2.00409105
70Ketosis (HP:0001946)1.96880505
71Absent thumb (HP:0009777)1.93961935
72Large for gestational age (HP:0001520)1.91897541
73Opisthotonus (HP:0002179)1.85433832
74Concave nail (HP:0001598)1.85273990
75Polydipsia (HP:0001959)1.84940904
76Abnormal drinking behavior (HP:0030082)1.84940904
77Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84490843
78Attenuation of retinal blood vessels (HP:0007843)1.83291142
79Abnormality of vitamin B metabolism (HP:0004340)1.82736036
80Leukodystrophy (HP:0002415)1.82373392
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80207872
82Cystic liver disease (HP:0006706)1.79136949
83Hypoplasia of the uterus (HP:0000013)1.77735695
84Progressive microcephaly (HP:0000253)1.76892896
85Hyperglycinemia (HP:0002154)1.75224677
86Ketoacidosis (HP:0001993)1.75091395
87Furrowed tongue (HP:0000221)1.74451428
88Colon cancer (HP:0003003)1.72886741
89Hypoalbuminemia (HP:0003073)1.72544833
90Abnormal albumin level (HP:0012116)1.72544833
91Hypothermia (HP:0002045)1.72217305
92Anencephaly (HP:0002323)1.72211706
93Metabolic acidosis (HP:0001942)1.71630595
94CNS demyelination (HP:0007305)1.71345067
95Abnormality of serum amino acid levels (HP:0003112)1.71318108
96Abnormality of the vitamin B12 metabolism (HP:0004341)1.70994490
97Dicarboxylic aciduria (HP:0003215)1.68466765
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68466765
99Male pseudohermaphroditism (HP:0000037)1.66614958
100Adrenal hypoplasia (HP:0000835)1.65075201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.68485941
2VRK23.96035588
3BUB13.30841181
4FRK3.10955083
5TESK22.88660127
6STK162.54833507
7TXK2.50016002
8NUAK12.47409542
9ZAK2.42616375
10BCKDK2.40209706
11ADRBK22.30537169
12BMPR1B2.29295205
13GRK12.13800232
14MAP4K22.13723741
15MST42.10799051
16VRK11.94654607
17INSRR1.86036992
18PHKG21.74641175
19PHKG11.74641175
20TAF11.64512060
21TAOK31.63397675
22WNK31.62264897
23LIMK11.53448828
24KDR1.41650584
25PINK11.31050809
26NME11.27795136
27WNK41.25946918
28TESK11.18386347
29CDC71.18354816
30CDK81.13336205
31DYRK21.12017968
32SRPK11.09636539
33EIF2AK11.08945170
34MAPKAPK31.07359415
35PLK31.03193773
36IKBKB1.00376666
37PLK40.99626590
38PLK20.95318757
39CSNK1G30.92485709
40MAP2K70.91704286
41OXSR10.90811011
42NME20.90721021
43CAMKK20.87432086
44ITK0.83673151
45MAPK130.80857699
46CSNK1G10.80696063
47GRK50.80221297
48CSNK1G20.79037462
49TRIM280.77083637
50GRK60.76659801
51MAPKAPK50.74987519
52STK390.74126738
53ADRBK10.71219050
54DAPK10.70513806
55PLK10.70074525
56PRKCI0.69732507
57RPS6KA50.69029404
58ABL20.68273315
59EIF2AK30.64466803
60CSNK1A1L0.63753829
61ACVR1B0.62540790
62TNIK0.59164839
63CDK190.58540394
64MAP2K60.57429449
65KIT0.56169373
66CHEK20.54801159
67CSNK1A10.54517711
68GRK70.52320810
69MUSK0.51643545
70DAPK20.50442332
71PRKCG0.49579513
72CSNK2A10.47962978
73TIE10.47901086
74AURKA0.47723858
75MAP3K120.47372169
76CCNB10.46364049
77SYK0.46249339
78EIF2AK20.45935250
79PRKCE0.45135379
80AURKB0.44369509
81IKBKE0.44076478
82PIM20.43775602
83TGFBR10.43685443
84MAP3K40.43213868
85PTK2B0.42582642
86TEC0.42478594
87PRKCQ0.42316748
88CSNK2A20.41398878
89ATR0.40797385
90NEK20.40749686
91MAP2K20.37781944
92PRKACA0.37305947
93PDK20.37140897
94PASK0.36539045
95PAK30.34163733
96BRSK20.31237929
97PIK3CA0.30599967
98CHUK0.28841463
99PIM10.27512398
100ILK0.25844844

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.25658127
2Ribosome_Homo sapiens_hsa030103.82172266
3Proteasome_Homo sapiens_hsa030503.60314783
4Parkinsons disease_Homo sapiens_hsa050123.48726712
5RNA polymerase_Homo sapiens_hsa030203.36142228
6Protein export_Homo sapiens_hsa030602.71404065
7Homologous recombination_Homo sapiens_hsa034402.44731254
8Huntingtons disease_Homo sapiens_hsa050162.42056167
9Alzheimers disease_Homo sapiens_hsa050102.32429786
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13945584
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.09461564
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08707168
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93177433
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84198648
15Cardiac muscle contraction_Homo sapiens_hsa042601.73849017
16Pyrimidine metabolism_Homo sapiens_hsa002401.72580480
17Phototransduction_Homo sapiens_hsa047441.64188466
18DNA replication_Homo sapiens_hsa030301.63783323
19Mismatch repair_Homo sapiens_hsa034301.60975664
20Basal transcription factors_Homo sapiens_hsa030221.60342346
21RNA degradation_Homo sapiens_hsa030181.58283176
22Sulfur relay system_Homo sapiens_hsa041221.54316754
23One carbon pool by folate_Homo sapiens_hsa006701.53202908
24Fanconi anemia pathway_Homo sapiens_hsa034601.52232681
25Base excision repair_Homo sapiens_hsa034101.46691232
26Nucleotide excision repair_Homo sapiens_hsa034201.42259038
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.39601041
28Primary immunodeficiency_Homo sapiens_hsa053401.29620074
29Caffeine metabolism_Homo sapiens_hsa002321.29017441
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.27552727
31Purine metabolism_Homo sapiens_hsa002301.27191277
32Collecting duct acid secretion_Homo sapiens_hsa049661.24041418
33Spliceosome_Homo sapiens_hsa030401.15457525
34Linoleic acid metabolism_Homo sapiens_hsa005911.15250808
35Nitrogen metabolism_Homo sapiens_hsa009101.15008395
36Selenocompound metabolism_Homo sapiens_hsa004501.09851702
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09189150
38Graft-versus-host disease_Homo sapiens_hsa053321.08321500
39Tryptophan metabolism_Homo sapiens_hsa003801.07013717
40Sulfur metabolism_Homo sapiens_hsa009201.05812357
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04795199
42Folate biosynthesis_Homo sapiens_hsa007900.99659901
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99072956
44Asthma_Homo sapiens_hsa053100.97735759
45Autoimmune thyroid disease_Homo sapiens_hsa053200.96062988
46Allograft rejection_Homo sapiens_hsa053300.95479450
47Butanoate metabolism_Homo sapiens_hsa006500.93108354
48Type I diabetes mellitus_Homo sapiens_hsa049400.91966446
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90540888
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86345342
51RNA transport_Homo sapiens_hsa030130.85108460
52Fatty acid elongation_Homo sapiens_hsa000620.82065887
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81491254
54Peroxisome_Homo sapiens_hsa041460.81385234
55Propanoate metabolism_Homo sapiens_hsa006400.81361932
56Metabolic pathways_Homo sapiens_hsa011000.78306710
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77656769
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76177820
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.74409064
60Pyruvate metabolism_Homo sapiens_hsa006200.71200519
61Regulation of autophagy_Homo sapiens_hsa041400.69692001
62Chemical carcinogenesis_Homo sapiens_hsa052040.69372906
63Antigen processing and presentation_Homo sapiens_hsa046120.69040805
64Nicotine addiction_Homo sapiens_hsa050330.67724112
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.65806147
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65076436
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64169975
68Rheumatoid arthritis_Homo sapiens_hsa053230.61536515
69Vitamin digestion and absorption_Homo sapiens_hsa049770.60336447
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58836283
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.58652245
72Arachidonic acid metabolism_Homo sapiens_hsa005900.57416721
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56686151
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55973979
75Retinol metabolism_Homo sapiens_hsa008300.53283042
76Ether lipid metabolism_Homo sapiens_hsa005650.51690748
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.48954867
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47428287
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46920612
80Non-homologous end-joining_Homo sapiens_hsa034500.46511735
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46326259
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45515857
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44641904
84Glutathione metabolism_Homo sapiens_hsa004800.44580102
85Olfactory transduction_Homo sapiens_hsa047400.43251474
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42363098
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40347136
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37892063
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37612169
90Fat digestion and absorption_Homo sapiens_hsa049750.37046421
91beta-Alanine metabolism_Homo sapiens_hsa004100.35005820
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32782034
93Morphine addiction_Homo sapiens_hsa050320.31347810
94Mineral absorption_Homo sapiens_hsa049780.29796390
95Hematopoietic cell lineage_Homo sapiens_hsa046400.27927827
96Fatty acid degradation_Homo sapiens_hsa000710.27074058
97Epstein-Barr virus infection_Homo sapiens_hsa051690.24259110
98p53 signaling pathway_Homo sapiens_hsa041150.24240894
99Taste transduction_Homo sapiens_hsa047420.23636529
100Tyrosine metabolism_Homo sapiens_hsa003500.21787766

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »