EIF4H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.20367771
2protein localization to kinetochore (GO:0034501)4.64883065
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.47499755
4proline biosynthetic process (GO:0006561)4.46990568
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.42737696
6folic acid-containing compound biosynthetic process (GO:0009396)4.41976485
7regulation of translational termination (GO:0006449)4.40926037
8protein retention in ER lumen (GO:0006621)4.34177941
9DNA strand elongation involved in DNA replication (GO:0006271)4.27867761
10heterochromatin organization (GO:0070828)4.16602998
11DNA replication-dependent nucleosome organization (GO:0034723)4.05974034
12DNA replication-dependent nucleosome assembly (GO:0006335)4.05974034
13IMP biosynthetic process (GO:0006188)4.04623208
14regulation of translational fidelity (GO:0006450)4.04332001
15formation of translation preinitiation complex (GO:0001731)4.00714136
16DNA strand elongation (GO:0022616)3.97500881
17DNA replication initiation (GO:0006270)3.97000291
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.95235993
19nucleobase biosynthetic process (GO:0046112)3.84667066
20peptidyl-arginine omega-N-methylation (GO:0035247)3.80862497
21mitotic nuclear envelope disassembly (GO:0007077)3.80000854
22peptidyl-lysine dimethylation (GO:0018027)3.76214172
23protein localization to chromosome, centromeric region (GO:0071459)3.72525610
24membrane disassembly (GO:0030397)3.70945297
25nuclear envelope disassembly (GO:0051081)3.70945297
26IMP metabolic process (GO:0046040)3.67420595
27protein localization to endosome (GO:0036010)3.65388459
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62719776
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.59949201
30regulation of mammary gland epithelial cell proliferation (GO:0033599)3.59792760
31DNA duplex unwinding (GO:0032508)3.59584877
32mitotic chromosome condensation (GO:0007076)3.58342590
33cellular protein complex localization (GO:0034629)3.55493816
34DNA geometric change (GO:0032392)3.55305595
35negative regulation of RNA splicing (GO:0033119)3.55134465
36nuclear pore organization (GO:0006999)3.54537681
37regulation of spindle organization (GO:0090224)3.47311506
38pore complex assembly (GO:0046931)3.33019937
39mitotic G1 DNA damage checkpoint (GO:0031571)3.32950380
40focal adhesion assembly (GO:0048041)3.32261520
41cell-substrate adherens junction assembly (GO:0007045)3.32261520
42pre-miRNA processing (GO:0031054)3.31158808
43adherens junction assembly (GO:0034333)3.30623722
44peptidyl-arginine methylation (GO:0018216)3.30066224
45peptidyl-arginine N-methylation (GO:0035246)3.30066224
46purine nucleobase biosynthetic process (GO:0009113)3.29316326
47nuclear pore complex assembly (GO:0051292)3.28797190
48negative regulation of histone methylation (GO:0031061)3.21574573
49telomere maintenance via semi-conservative replication (GO:0032201)3.20785329
50dosage compensation (GO:0007549)3.20604924
51mitotic metaphase plate congression (GO:0007080)3.20452852
52sister chromatid segregation (GO:0000819)3.18172451
53nuclear envelope organization (GO:0006998)3.17491666
54negative regulation of mRNA processing (GO:0050686)3.16604878
55translesion synthesis (GO:0019985)3.15826210
56viral transcription (GO:0019083)3.15672749
57regulation of early endosome to late endosome transport (GO:2000641)3.14888989
58cytoskeletal anchoring at plasma membrane (GO:0007016)3.13967883
59histone-serine phosphorylation (GO:0035404)3.12950250
60protein complex localization (GO:0031503)3.12568771
61translational termination (GO:0006415)3.11387491
62ribosome assembly (GO:0042255)3.10827328
63NADPH regeneration (GO:0006740)3.10624025
64NADH metabolic process (GO:0006734)3.10189546
65activation of Rac GTPase activity (GO:0032863)3.09909529
66protein maturation by protein folding (GO:0022417)3.09417069
67translational elongation (GO:0006414)3.08297497
68negative regulation of erythrocyte differentiation (GO:0045647)3.07885379
69mitotic sister chromatid segregation (GO:0000070)3.07559056
70vesicle coating (GO:0006901)3.06409931
71maturation of SSU-rRNA (GO:0030490)3.05006818
72chromatin assembly (GO:0031497)3.04502950
73regulation of nucleobase-containing compound transport (GO:0032239)3.04224019
74protein export from nucleus (GO:0006611)3.03915688
75histone arginine methylation (GO:0034969)3.03698917
76regulation of mitotic spindle organization (GO:0060236)3.02454846
77* translational initiation (GO:0006413)3.01516502
78pinocytosis (GO:0006907)3.01235928
79positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.01015226
80regulation of RNA export from nucleus (GO:0046831)2.99956114
81nucleobase-containing small molecule interconversion (GO:0015949)2.98805148
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98519403
83chromatin assembly or disassembly (GO:0006333)2.98220298
84activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.97979670
85negative regulation of mRNA metabolic process (GO:1903312)2.97155239
86positive regulation of nuclease activity (GO:0032075)2.96894789
87regulation of sister chromatid cohesion (GO:0007063)2.96870327
88glucose catabolic process (GO:0006007)2.93878778
89nuclear envelope reassembly (GO:0031468)2.91664971
90mitotic nuclear envelope reassembly (GO:0007084)2.91664971
91regulation of histone H3-K9 methylation (GO:0051570)2.91123907
92DNA replication checkpoint (GO:0000076)2.90673847
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90125470
94mitotic recombination (GO:0006312)2.88794994
95alternative mRNA splicing, via spliceosome (GO:0000380)2.88741261
96maternal placenta development (GO:0001893)2.88641456
97glucocorticoid receptor signaling pathway (GO:0042921)2.88178378
98COPI coating of Golgi vesicle (GO:0048205)2.85870628
99Golgi transport vesicle coating (GO:0048200)2.85870628
100embryonic process involved in female pregnancy (GO:0060136)2.85488855
101epithelial cell differentiation involved in prostate gland development (GO:0060742)2.85092250
102positive regulation of chromosome segregation (GO:0051984)2.83907460
103establishment of integrated proviral latency (GO:0075713)2.83791138
104regulation of glucose import in response to insulin stimulus (GO:2001273)2.83585921
105proline metabolic process (GO:0006560)2.83476858
106regulation of histone H3-K27 methylation (GO:0061085)2.81404833
107glycolytic process (GO:0006096)2.80520486
108folic acid metabolic process (GO:0046655)2.79148312
109endoplasmic reticulum unfolded protein response (GO:0030968)2.79080731
110regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.78355546
111positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.78355546
112cell-substrate junction assembly (GO:0007044)2.78246780
113ribosomal small subunit assembly (GO:0000028)2.77979483
114glucose 6-phosphate metabolic process (GO:0051156)2.77913888
115negative regulation of cell size (GO:0045792)2.77886805
116DNA conformation change (GO:0071103)2.77651520
1173-UTR-mediated mRNA stabilization (GO:0070935)2.76487005
118regulation of chromosome segregation (GO:0051983)2.75356450
119chromosome condensation (GO:0030261)2.75284742
120protein localization to chromosome (GO:0034502)2.74948385
121regulation of posttranscriptional gene silencing (GO:0060147)2.74470495
122regulation of gene silencing by miRNA (GO:0060964)2.74470495
123regulation of gene silencing by RNA (GO:0060966)2.74470495
124postreplication repair (GO:0006301)2.73418223
125pentose-phosphate shunt (GO:0006098)2.73054541
126regulation of hippo signaling (GO:0035330)2.72560278
127mitotic G1/S transition checkpoint (GO:0044819)2.71380960
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.70707164
129ER-nucleus signaling pathway (GO:0006984)2.70432431
130ncRNA 3-end processing (GO:0043628)2.70236197
131RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.70145904
132mRNA splicing, via spliceosome (GO:0000398)2.70145904
133tricarboxylic acid metabolic process (GO:0072350)2.68639576
134barbed-end actin filament capping (GO:0051016)2.67854541
135spliceosomal tri-snRNP complex assembly (GO:0000244)2.67134744
136negative regulation of chromosome segregation (GO:0051985)2.66295712
137embryonic foregut morphogenesis (GO:0048617)2.66047358
138metaphase plate congression (GO:0051310)2.66030564
139mRNA stabilization (GO:0048255)2.65910095
140RNA stabilization (GO:0043489)2.65910095
141regulation of nuclease activity (GO:0032069)2.65452746
142ribosome biogenesis (GO:0042254)2.65358772
143RNA splicing, via transesterification reactions (GO:0000375)2.65074915
144apoptotic process involved in morphogenesis (GO:0060561)2.65059261
145mitotic spindle assembly checkpoint (GO:0007094)2.64975800
146nucleosome disassembly (GO:0006337)2.64562125
147protein-DNA complex disassembly (GO:0032986)2.64562125
148G1 DNA damage checkpoint (GO:0044783)2.64248422
149telomere maintenance via recombination (GO:0000722)2.64061449
150DNA topological change (GO:0006265)2.60859525
151cellular response to unfolded protein (GO:0034620)2.54398690
152epithelial cell-cell adhesion (GO:0090136)2.53658259
153mitochondrial fusion (GO:0008053)2.53107003
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.51911277
155cellular hyperosmotic response (GO:0071474)2.51725030
156desmosome organization (GO:0002934)2.51428314
157regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.49571066
158peptidyl-proline hydroxylation (GO:0019511)2.44079699
159glutamine family amino acid biosynthetic process (GO:0009084)2.41224941
160positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.40709240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.55817933
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.45579377
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83472622
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.57542031
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.11630124
6MYC_22102868_ChIP-Seq_BL_Human2.88702534
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82469091
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77240185
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48091854
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35289847
11XRN2_22483619_ChIP-Seq_HELA_Human2.21457184
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18869284
13AR_21909140_ChIP-Seq_LNCAP_Human2.14034763
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11176403
15VDR_21846776_ChIP-Seq_THP-1_Human1.93193784
16NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90092711
17ZNF263_19887448_ChIP-Seq_K562_Human1.85433174
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83959915
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81505831
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.80889730
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77486515
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.73027402
23* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72758014
24CIITA_25753668_ChIP-Seq_RAJI_Human1.71228496
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63225564
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62299173
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61603147
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60181378
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59993492
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58860557
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.57539275
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.57134348
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56869421
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56690994
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52765603
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51586236
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50624287
38* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50025186
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44753574
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43766358
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43223143
42GABP_19822575_ChIP-Seq_HepG2_Human1.42719736
43KDM2B_26808549_Chip-Seq_DND41_Human1.41928478
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41231902
45* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41034633
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40583034
47KDM5A_27292631_Chip-Seq_BREAST_Human1.38443778
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38051799
49TCF7_22412390_ChIP-Seq_EML_Mouse1.37521409
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34886548
51* TTF2_22483619_ChIP-Seq_HELA_Human1.34729511
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32548318
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32473385
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32042359
55CLOCK_20551151_ChIP-Seq_293T_Human1.31595601
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31421935
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30940930
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29598525
59* ATF3_27146783_Chip-Seq_COLON_Human1.29279515
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25042810
61* DCP1A_22483619_ChIP-Seq_HELA_Human1.24399836
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22799777
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.21726215
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21413232
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20843537
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.20405924
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19924146
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19489964
69* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19433878
70LXR_22292898_ChIP-Seq_THP-1_Human1.19206550
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19037366
72TFEB_21752829_ChIP-Seq_HELA_Human1.18855480
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18260869
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18040884
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16971140
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16944675
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14653965
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14535664
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14419144
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14070821
81KDM2B_26808549_Chip-Seq_K562_Human1.13978736
82FOXP3_21729870_ChIP-Seq_TREG_Human1.12902885
83RACK7_27058665_Chip-Seq_MCF-7_Human1.12698075
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12683947
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12077078
86* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11914703
87VDR_23849224_ChIP-Seq_CD4+_Human1.11060808
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10752774
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10406640
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07838556
91CHD1_26751641_Chip-Seq_LNCaP_Human1.07561054
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07334222
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06954339
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.06488877
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06085513
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05999574
97UTX_26944678_Chip-Seq_JUKART_Human1.05777735
98* NANOG_21062744_ChIP-ChIP_HESCs_Human1.03681127
99P68_20966046_ChIP-Seq_HELA_Human1.01772624
100NCOR1_26117541_ChIP-Seq_K562_Human1.01534796
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.00798435
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00737909
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00431405
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99671654
105* FOXP1_21924763_ChIP-Seq_HESCs_Human0.99324493
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99316109
107MAF_26560356_Chip-Seq_TH1_Human0.98996386
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.98145673
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97981283
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97601788
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.97589743
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96462281
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96193563
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.95815278
115SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95651745
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95302027
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95225601
118CREB1_26743006_Chip-Seq_LNCaP_Human0.95047244
119OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94639195
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94466262
121SMC4_20622854_ChIP-Seq_HELA_Human0.94303914
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94037476
123* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93853921
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93450099
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93398620
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93301280
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91118593
128TP53_22127205_ChIP-Seq_IMR90_Human0.90239500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.81495744
2MP0003693_abnormal_embryo_hatching3.65695669
3MP0003111_abnormal_nucleus_morphology3.63319894
4MP0004957_abnormal_blastocyst_morpholog3.52572266
5MP0010352_gastrointestinal_tract_polyps3.45065907
6MP0003123_paternal_imprinting3.13703065
7MP0010094_abnormal_chromosome_stability3.02147934
8MP0003077_abnormal_cell_cycle2.99513355
9MP0001730_embryonic_growth_arrest2.82082869
10MP0000537_abnormal_urethra_morphology2.74873161
11MP0005451_abnormal_body_composition2.73526334
12MP0010030_abnormal_orbit_morphology2.63844303
13MP0010234_abnormal_vibrissa_follicle2.51389285
14MP0002796_impaired_skin_barrier2.41001016
15MP0008007_abnormal_cellular_replicative2.37468143
16MP0000350_abnormal_cell_proliferation2.23417120
17MP0005076_abnormal_cell_differentiation2.12594810
18MP0005058_abnormal_lysosome_morphology2.07902811
19MP0010307_abnormal_tumor_latency2.01515589
20MP0003283_abnormal_digestive_organ1.98663260
21MP0006054_spinal_hemorrhage1.98332319
22MP0008260_abnormal_autophagy1.98083514
23MP0008932_abnormal_embryonic_tissue1.98065167
24MP0001697_abnormal_embryo_size1.95867279
25MP0002084_abnormal_developmental_patter1.91283091
26MP0005380_embryogenesis_phenotype1.89466277
27MP0001672_abnormal_embryogenesis/_devel1.89466277
28MP0004197_abnormal_fetal_growth/weight/1.87436243
29MP0002080_prenatal_lethality1.87115677
30MP0001849_ear_inflammation1.79662380
31MP0003984_embryonic_growth_retardation1.77991878
32MP0002085_abnormal_embryonic_tissue1.77077792
33MP0002088_abnormal_embryonic_growth/wei1.74893991
34MP0003453_abnormal_keratinocyte_physiol1.73881198
35MP0002086_abnormal_extraembryonic_tissu1.72635854
36MP0003191_abnormal_cellular_cholesterol1.66171426
37MP0004808_abnormal_hematopoietic_stem1.58547026
38MP0002396_abnormal_hematopoietic_system1.57303320
39MP0003119_abnormal_digestive_system1.56963186
40MP0002060_abnormal_skin_morphology1.54460434
41MP0004233_abnormal_muscle_weight1.51405928
42MP0003566_abnormal_cell_adhesion1.50793855
43MP0003567_abnormal_fetal_cardiomyocyte1.48377258
44MP0005623_abnormal_meninges_morphology1.44247428
45MP0002089_abnormal_postnatal_growth/wei1.42270365
46MP0009278_abnormal_bone_marrow1.39830969
47MP0004782_abnormal_surfactant_physiolog1.39716404
48MP0003115_abnormal_respiratory_system1.37207801
49MP0000733_abnormal_muscle_development1.37114715
50MP0005257_abnormal_intraocular_pressure1.36642028
51MP0005409_darkened_coat_color1.35006833
52MP0002009_preneoplasia1.34616839
53MP0003121_genomic_imprinting1.33771194
54MP0001348_abnormal_lacrimal_gland1.32579663
55MP0000678_abnormal_parathyroid_gland1.32095236
56MP0009672_abnormal_birth_weight1.31681184
57MP0004264_abnormal_extraembryonic_tissu1.31118010
58MP0003300_gastrointestinal_ulcer1.30002789
59MP0008057_abnormal_DNA_replication1.29084697
60MP0000858_altered_metastatic_potential1.28126724
61MP0003941_abnormal_skin_development1.27221042
62MP0000490_abnormal_crypts_of1.26796520
63MP0005666_abnormal_adipose_tissue1.25433287
64MP0004947_skin_inflammation1.23855625
65MP0000428_abnormal_craniofacial_morphol1.23487952
66MP0008058_abnormal_DNA_repair1.20933290
67MP0005023_abnormal_wound_healing1.18757240
68MP0000313_abnormal_cell_death1.17851761
69MP0008438_abnormal_cutaneous_collagen1.17264964
70MP0001216_abnormal_epidermal_layer1.16447145
71MP0003329_amyloid_beta_deposits1.16423852
72MP0009053_abnormal_anal_canal1.14936972
73MP0000751_myopathy1.11984061
74MP0001293_anophthalmia1.10326404
75MP0002653_abnormal_ependyma_morphology1.08403293
76MP0005375_adipose_tissue_phenotype1.08020407
77MP0003303_peritoneal_inflammation1.07496901
78MP0002019_abnormal_tumor_incidence1.06537731
79MP0008770_decreased_survivor_rate1.03845309
80MP0001958_emphysema1.03411797
81MP0000759_abnormal_skeletal_muscle0.98619793
82MP0003221_abnormal_cardiomyocyte_apopto0.98425687
83MP0009703_decreased_birth_body0.98005985
84MP0001915_intracranial_hemorrhage0.97891841
85MP0002877_abnormal_melanocyte_morpholog0.97701437
86MP0002111_abnormal_tail_morphology0.96758809
87MP0003122_maternal_imprinting0.96660465
88MP0001727_abnormal_embryo_implantation0.96561434
89MP0000467_abnormal_esophagus_morphology0.96476235
90MP0000377_abnormal_hair_follicle0.96102949
91MP0005397_hematopoietic_system_phenotyp0.95721880
92MP0001545_abnormal_hematopoietic_system0.95721880
93MP0002925_abnormal_cardiovascular_devel0.95228128
94MP0004272_abnormal_basement_membrane0.95005674
95MP0002098_abnormal_vibrissa_morphology0.93653511
96MP0001243_abnormal_dermal_layer0.90998582
97MP0009931_abnormal_skin_appearance0.90864899
98MP0008961_abnormal_basal_metabolism0.90668801
99MP0004087_abnormal_muscle_fiber0.90572308
100MP0000358_abnormal_cell_content/0.90530862
101MP0000579_abnormal_nail_morphology0.90154601
102MP0004185_abnormal_adipocyte_glucose0.89490151
103MP0001881_abnormal_mammary_gland0.88911112
104MP0003890_abnormal_embryonic-extraembry0.87377251
105MP0004858_abnormal_nervous_system0.87351322
106MP0002092_abnormal_eye_morphology0.87206145
107MP0000477_abnormal_intestine_morphology0.86406342
108MP0000762_abnormal_tongue_morphology0.85877281
109MP0000627_abnormal_mammary_gland0.85356906
110MP0001661_extended_life_span0.85170074
111MP0001853_heart_inflammation0.84776831
112MP0000534_abnormal_ureter_morphology0.82769799
113MP0000003_abnormal_adipose_tissue0.82764119
114MP0005275_abnormal_skin_tensile0.82459482
115MP0003861_abnormal_nervous_system0.81954113
116MP0010771_integument_phenotype0.80782644
117MP0000703_abnormal_thymus_morphology0.80717991
118MP0004133_heterotaxia0.79957334
119MP0000681_abnormal_thyroid_gland0.79445109
120MP0000747_muscle_weakness0.78727246
121MP0005621_abnormal_cell_physiology0.77351923
122MP0005384_cellular_phenotype0.77238159
123MP0009840_abnormal_foam_cell0.77223510
124MP0000266_abnormal_heart_morphology0.74565181
125MP0003279_aneurysm0.73609300
126MP0005187_abnormal_penis_morphology0.73338585
127MP0005167_abnormal_blood-brain_barrier0.73326320
128MP0003935_abnormal_craniofacial_develop0.72750317
129MP0003091_abnormal_cell_migration0.72484980
130MP0002932_abnormal_joint_morphology0.70264531
131MP0010630_abnormal_cardiac_muscle0.70047050
132MP0000750_abnormal_muscle_regeneration0.66699830
133MP0005501_abnormal_skin_physiology0.66692906
134MP0002269_muscular_atrophy0.66563499
135MP0003942_abnormal_urinary_system0.66138381
136MP0010368_abnormal_lymphatic_system0.63895319
137MP0003385_abnormal_body_wall0.63601638
138MP0002697_abnormal_eye_size0.63500969
139MP0001784_abnormal_fluid_regulation0.63398118

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.26423986
2Ependymoma (HP:0002888)3.43307656
3Insomnia (HP:0100785)3.12160864
4Renal duplication (HP:0000075)3.08824506
5Overriding aorta (HP:0002623)3.04108118
6Protrusio acetabuli (HP:0003179)3.02693391
7Distal lower limb amyotrophy (HP:0008944)2.99712929
8Increased nuchal translucency (HP:0010880)2.95897516
9Selective tooth agenesis (HP:0001592)2.93380384
10Cerebral aneurysm (HP:0004944)2.87512557
11Shallow orbits (HP:0000586)2.83096762
12Colon cancer (HP:0003003)2.82342101
13Centrally nucleated skeletal muscle fibers (HP:0003687)2.79808050
14Vertebral compression fractures (HP:0002953)2.79442052
15Bowel diverticulosis (HP:0005222)2.74984699
16Pointed chin (HP:0000307)2.74918115
17Elfin facies (HP:0004428)2.69933176
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66273874
19Short 4th metacarpal (HP:0010044)2.66273874
20Abnormal gallbladder physiology (HP:0012438)2.62795240
21Cholecystitis (HP:0001082)2.62795240
22Renovascular hypertension (HP:0100817)2.61808046
23Abnormality of the astrocytes (HP:0100707)2.56141467
24Astrocytoma (HP:0009592)2.56141467
25Increased connective tissue (HP:0009025)2.52895049
26Distal lower limb muscle weakness (HP:0009053)2.46429230
27Adenoma sebaceum (HP:0009720)2.45271061
28Angiofibromas (HP:0010615)2.45271061
29Medulloblastoma (HP:0002885)2.40133678
30Hand muscle atrophy (HP:0009130)2.37170894
31Pelvic girdle muscle weakness (HP:0003749)2.36384270
32Proximal placement of thumb (HP:0009623)2.34787508
33Bladder diverticulum (HP:0000015)2.33764149
34Ankle contracture (HP:0006466)2.33430407
35Upper limb amyotrophy (HP:0009129)2.32273610
36Distal upper limb amyotrophy (HP:0007149)2.32273610
37Hallux valgus (HP:0001822)2.29887705
38Genu recurvatum (HP:0002816)2.26909008
39Achilles tendon contracture (HP:0001771)2.26430767
40Patellar dislocation (HP:0002999)2.26203872
41Deviation of the hallux (HP:0010051)2.26192426
42Deviation of the thumb (HP:0009603)2.25845943
43Lower limb amyotrophy (HP:0007210)2.24890860
44Long palpebral fissure (HP:0000637)2.24021207
45Basal cell carcinoma (HP:0002671)2.23203078
46Broad face (HP:0000283)2.20850894
47Flat cornea (HP:0007720)2.20806246
48Degeneration of anterior horn cells (HP:0002398)2.19756003
49Abnormality of the anterior horn cell (HP:0006802)2.19756003
50Slender long bone (HP:0003100)2.19748762
51Abnormality of the calcaneus (HP:0008364)2.17811216
52Spinal rigidity (HP:0003306)2.17583718
53Progressive muscle weakness (HP:0003323)2.17306879
54Termporal pattern (HP:0011008)2.17025657
55Insidious onset (HP:0003587)2.17025657
56Trismus (HP:0000211)2.16910140
57Overlapping toe (HP:0001845)2.14349601
58Enlarged penis (HP:0000040)2.11709167
59Shoulder girdle muscle weakness (HP:0003547)2.11450821
60Ragged-red muscle fibers (HP:0003200)2.11401325
61Abnormality of the lower motor neuron (HP:0002366)2.10953533
62Asymmetry of the thorax (HP:0001555)2.10895238
63Abnormality of the distal phalanges of the toes (HP:0010182)2.10633934
64Short nail (HP:0001799)2.10632235
65Multiple enchondromatosis (HP:0005701)2.10347381
66Reticulocytosis (HP:0001923)2.09936036
67Spastic diplegia (HP:0001264)2.09803744
68Disproportionate tall stature (HP:0001519)2.08711535
69High pitched voice (HP:0001620)2.08127979
70Premature rupture of membranes (HP:0001788)2.06345289
71Ankyloglossia (HP:0010296)2.05515236
72Deep palmar crease (HP:0006191)2.05018595
73Fibroma (HP:0010614)2.03075430
74Intestinal polyp (HP:0005266)2.03007250
75Flat acetabular roof (HP:0003180)2.00884771
76Abnormality of the hip-girdle musculature (HP:0001445)2.00749349
77Abnormality of the musculature of the pelvis (HP:0001469)2.00749349
78Atresia of the external auditory canal (HP:0000413)2.00712236
79Abnormality of the 4th metacarpal (HP:0010012)2.00635695
80Megalocornea (HP:0000485)1.98506983
81Annular pancreas (HP:0001734)1.98443020
82Advanced eruption of teeth (HP:0006288)1.97203686
83Fibrous tissue neoplasm (HP:0012316)1.95949266
84Increased density of long bones (HP:0006392)1.95811124
85Glioma (HP:0009733)1.94988466
86Dysmetric saccades (HP:0000641)1.94417755
87Intestinal polyposis (HP:0200008)1.92873009
88Spinal cord lesions (HP:0100561)1.92715040
89Syringomyelia (HP:0003396)1.92715040
90Broad palm (HP:0001169)1.92499479
91Osteolytic defects of the hand bones (HP:0009699)1.92326665
92Osteolytic defects of the phalanges of the hand (HP:0009771)1.92326665
93Gastrointestinal carcinoma (HP:0002672)1.90905799
94Malignant gastrointestinal tract tumors (HP:0006749)1.90905799
95Abnormality of the Achilles tendon (HP:0005109)1.90667513
96Natal tooth (HP:0000695)1.89056787
97Birth length less than 3rd percentile (HP:0003561)1.88999767
98Hypercalcemia (HP:0003072)1.88533626
99Hyperparathyroidism (HP:0000843)1.88452425
100Back pain (HP:0003418)1.86963416
101Missing ribs (HP:0000921)1.86618277
102Neoplasm of the pancreas (HP:0002894)1.85008808
103Abnormality of skeletal muscle fiber size (HP:0012084)1.84268343
104Microretrognathia (HP:0000308)1.83600018
105Neoplasm of striated muscle (HP:0009728)1.83457566
106Rectal prolapse (HP:0002035)1.82731930
107Adducted thumb (HP:0001181)1.81877167
108Hammertoe (HP:0001765)1.81692602
109Cerebral hypomyelination (HP:0006808)1.81291846
110Mildly elevated creatine phosphokinase (HP:0008180)1.80830936
111Abnormality of cells of the erythroid lineage (HP:0012130)1.80625096
112Broad distal phalanx of finger (HP:0009836)1.80569209
113Dilatation of the ascending aorta (HP:0005111)1.80019863
114Limb-girdle muscle atrophy (HP:0003797)1.79964284
115Breech presentation (HP:0001623)1.78690318
116Myopathic facies (HP:0002058)1.78192456
117Rhabdomyosarcoma (HP:0002859)1.78048864
118Progressive external ophthalmoplegia (HP:0000590)1.77621204
119Skin tags (HP:0010609)1.77528476
120Abnormality of oral frenula (HP:0000190)1.77062958
121Mitral regurgitation (HP:0001653)1.75222405
122Microvesicular hepatic steatosis (HP:0001414)1.75172845
123Mitral valve prolapse (HP:0001634)1.74527595
124Increased variability in muscle fiber diameter (HP:0003557)1.74074490
125Atrophy/Degeneration involving motor neurons (HP:0007373)1.73607620
126Breast hypoplasia (HP:0003187)1.73031486
127Ulnar bowing (HP:0003031)1.72949763
128Upper limb muscle weakness (HP:0003484)1.72405740
129Glossoptosis (HP:0000162)1.72235757
130Bicuspid aortic valve (HP:0001647)1.71847367
131Abnormality of the umbilical cord (HP:0010881)1.71360032
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.71233642
133Preauricular skin tag (HP:0000384)1.71062099
134Calcaneovalgus deformity (HP:0001848)1.70990218
135Abnormality of nail color (HP:0100643)1.70592011
136Difficulty climbing stairs (HP:0003551)1.70205584
137Distal sensory impairment (HP:0002936)1.70008172
138Truncus arteriosus (HP:0001660)1.69730699
139Elbow flexion contracture (HP:0002987)1.68405240
140Neoplasm of the heart (HP:0100544)1.67946709
141Bowel incontinence (HP:0002607)1.67426920
142Vertebral arch anomaly (HP:0008438)1.67018137
143Patellar aplasia (HP:0006443)1.66864428
144Wormian bones (HP:0002645)1.66140389
145Orthostatic hypotension (HP:0001278)1.65869138
146Fragile skin (HP:0001030)1.65838587
147Arnold-Chiari malformation (HP:0002308)1.65291882
148Cellulitis (HP:0100658)1.64600016
149Abnormal number of erythroid precursors (HP:0012131)1.64245019
150Subacute progressive viral hepatitis (HP:0006572)1.63809990
151Hypoplastic toenails (HP:0001800)1.63370035
152Pseudobulbar signs (HP:0002200)1.62623483
153Abnormality of the tricuspid valve (HP:0001702)1.62196995
154Biliary tract neoplasm (HP:0100574)1.61563356
155Abnormal large intestine physiology (HP:0012700)1.60866979
156Abnormality of glycolysis (HP:0004366)1.60639607
157Cortical dysplasia (HP:0002539)1.60274415
158Interstitial pulmonary disease (HP:0006530)1.59355254
159Cervical subluxation (HP:0003308)1.58804386
160Entropion (HP:0000621)1.58412694
161Biconcave vertebral bodies (HP:0004586)1.56916032
162Relative macrocephaly (HP:0004482)1.56508578
163Sparse lateral eyebrow (HP:0005338)1.55819412
164Precocious puberty (HP:0000826)1.55419562
165Foot dorsiflexor weakness (HP:0009027)1.55401645
166Abnormality of reticulocytes (HP:0004312)1.54805193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.44898005
2PKN23.83089753
3EEF2K3.56055615
4SMG13.35987339
5BUB13.22007424
6PRPF4B3.06201182
7MAP3K102.90032147
8CDC72.86694203
9NEK22.65633208
10SCYL22.55513595
11WEE12.42028615
12NEK12.29710578
13TESK22.25506408
14IRAK32.25163131
15PAK41.88999712
16PASK1.75290086
17SIK11.68032263
18ARAF1.67144407
19ALK1.64621551
20RIPK11.61572103
21MAP3K81.54420605
22LRRK21.52005050
23PTK61.50930617
24TSSK61.45484694
25EIF2AK11.44222948
26RPS6KA41.43540347
27TTK1.43054573
28FGFR41.40324533
29PDGFRA1.39328513
30RPS6KB21.37729651
31MAP3K91.37492311
32TESK11.37116988
33KSR21.36243170
34CDK41.29049633
35TGFBR11.28231605
36MST1R1.26827602
37NTRK11.23311728
38PIM21.13123490
39TAOK21.12900931
40PRKD31.12874648
41DYRK31.11067800
42PLK11.10134030
43BRSK11.09398441
44TTN1.08346024
45LATS21.07225689
46STK101.06277292
47PBK1.06089025
48MAP3K131.05704424
49CDK121.05358615
50MAP3K110.96542133
51CDK60.96370028
52TYRO30.95551662
53TLK10.94706709
54EPHA20.94228358
55AURKB0.94134912
56CDK70.92065830
57ILK0.91974790
58BRAF0.91381878
59AURKA0.88634242
60FGFR10.87785547
61TAOK10.87528992
62ATR0.86752150
63PAK20.83758141
64LIMK10.82791094
65MOS0.82734945
66FLT30.81790137
67MTOR0.81562410
68CHEK10.77195409
69PAK10.77026850
70MET0.76468499
71MAP2K30.74098223
72KSR10.70023980
73LMTK20.69802172
74MAPKAPK30.69379923
75CAMKK10.68710002
76MAP3K10.68027003
77MKNK10.67203510
78ICK0.66307971
79NME20.65507723
80MAP2K20.64059743
81CDK20.63840649
82PAK60.62328199
83ERN10.61961774
84MAP3K140.61835100
85BMX0.61466763
86PLK30.61053402
87RET0.59976821
88EPHB10.57755795
89DDR20.57433309
90PTK20.57407772
91CDK140.56213556
92BRSK20.56081372
93CLK10.55023416
94ERBB40.54945414
95CDK150.54597647
96MAP4K10.53852352
97CDK80.52930604
98CDK11A0.52095946
99AKT20.51494130
100GRK60.50964135
101RPS6KA20.49782026
102PDPK10.48694819
103KDR0.48113630
104BRD40.47515323
105CHEK20.47255740
106CDK180.47004099
107RAF10.46443732
108IRAK20.45834226
109UHMK10.45151099
110MINK10.44427164
111SIK30.44290603
112NEK90.43148308
113MAP3K60.41294405
114MAP3K30.41082245
115DMPK0.40475695
116CSNK1E0.40428200
117CDK90.40003154
118FER0.39833284
119TBK10.39010779
120DAPK30.37486836
121CDK10.37486162
122PRKCI0.36735206
123ZAP700.36000890
124SRPK10.35838622
125ATM0.35394941
126MELK0.34855279
127DYRK1B0.34804869
128MARK20.34300808
129STK40.33436887
130MAPK110.31694876
131PRKDC0.31286809
132DAPK10.30241584

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.17247680
2Mismatch repair_Homo sapiens_hsa034302.93863541
3RNA transport_Homo sapiens_hsa030132.75281215
4Spliceosome_Homo sapiens_hsa030402.73551937
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.58771974
6Cell cycle_Homo sapiens_hsa041102.53176729
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44787697
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19908257
9Base excision repair_Homo sapiens_hsa034102.17281297
10One carbon pool by folate_Homo sapiens_hsa006702.13359244
11mRNA surveillance pathway_Homo sapiens_hsa030151.80657960
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.73706801
13Oocyte meiosis_Homo sapiens_hsa041141.72432053
14Nucleotide excision repair_Homo sapiens_hsa034201.66870749
15Ribosome_Homo sapiens_hsa030101.64280699
16Fructose and mannose metabolism_Homo sapiens_hsa000511.55946464
17Chronic myeloid leukemia_Homo sapiens_hsa052201.54869394
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54836257
19Other glycan degradation_Homo sapiens_hsa005111.45980696
20Thyroid cancer_Homo sapiens_hsa052161.45783008
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44447797
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.42566576
23Prion diseases_Homo sapiens_hsa050201.40577667
24Bladder cancer_Homo sapiens_hsa052191.36962598
25Biosynthesis of amino acids_Homo sapiens_hsa012301.30284042
26Galactose metabolism_Homo sapiens_hsa000521.23738323
27Viral carcinogenesis_Homo sapiens_hsa052031.22217706
28Colorectal cancer_Homo sapiens_hsa052101.22108850
29Hippo signaling pathway_Homo sapiens_hsa043901.21782336
30Non-small cell lung cancer_Homo sapiens_hsa052231.20318590
31p53 signaling pathway_Homo sapiens_hsa041151.20083008
32mTOR signaling pathway_Homo sapiens_hsa041501.19678325
33Small cell lung cancer_Homo sapiens_hsa052221.16805905
34Homologous recombination_Homo sapiens_hsa034401.16483796
35MicroRNAs in cancer_Homo sapiens_hsa052061.15704892
36VEGF signaling pathway_Homo sapiens_hsa043701.14333165
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13930786
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10158256
39Glioma_Homo sapiens_hsa052141.09757172
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09003075
41ErbB signaling pathway_Homo sapiens_hsa040121.07829595
42HTLV-I infection_Homo sapiens_hsa051661.06504070
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.06170544
44Systemic lupus erythematosus_Homo sapiens_hsa053221.03714022
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03094024
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02592614
47Proteoglycans in cancer_Homo sapiens_hsa052051.01691560
48Vibrio cholerae infection_Homo sapiens_hsa051101.00875722
49Pyrimidine metabolism_Homo sapiens_hsa002400.98852779
50Endometrial cancer_Homo sapiens_hsa052130.97815050
51Alcoholism_Homo sapiens_hsa050340.96238224
52Nitrogen metabolism_Homo sapiens_hsa009100.95216779
53Proteasome_Homo sapiens_hsa030500.90988437
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88786448
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86835397
56Basal cell carcinoma_Homo sapiens_hsa052170.86655139
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85540572
58Epstein-Barr virus infection_Homo sapiens_hsa051690.85204404
59Shigellosis_Homo sapiens_hsa051310.84916731
60Prostate cancer_Homo sapiens_hsa052150.84860838
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84020542
62Tight junction_Homo sapiens_hsa045300.83495274
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.83364785
64Notch signaling pathway_Homo sapiens_hsa043300.80403188
65HIF-1 signaling pathway_Homo sapiens_hsa040660.80033044
66RNA polymerase_Homo sapiens_hsa030200.79499721
67Hedgehog signaling pathway_Homo sapiens_hsa043400.78685958
68Gap junction_Homo sapiens_hsa045400.78658539
69Focal adhesion_Homo sapiens_hsa045100.78479533
70Adherens junction_Homo sapiens_hsa045200.77645618
71Pentose phosphate pathway_Homo sapiens_hsa000300.77020809
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76668070
73Arginine biosynthesis_Homo sapiens_hsa002200.76093412
74Estrogen signaling pathway_Homo sapiens_hsa049150.75166090
75Pancreatic cancer_Homo sapiens_hsa052120.73764184
76Renal cell carcinoma_Homo sapiens_hsa052110.73378105
77Selenocompound metabolism_Homo sapiens_hsa004500.72594748
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.71272620
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70469344
80Acute myeloid leukemia_Homo sapiens_hsa052210.69360735
81RNA degradation_Homo sapiens_hsa030180.69347791
82Carbon metabolism_Homo sapiens_hsa012000.67712670
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64982200
84Hepatitis C_Homo sapiens_hsa051600.64958325
85Sulfur relay system_Homo sapiens_hsa041220.64941493
86Salmonella infection_Homo sapiens_hsa051320.64868393
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.63917912
88Vitamin B6 metabolism_Homo sapiens_hsa007500.63387691
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63316995
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63276524
91Apoptosis_Homo sapiens_hsa042100.62641576
92Antigen processing and presentation_Homo sapiens_hsa046120.62548952
93Inositol phosphate metabolism_Homo sapiens_hsa005620.62328575
94Endocytosis_Homo sapiens_hsa041440.62243262
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.62151295
96Non-homologous end-joining_Homo sapiens_hsa034500.61976829
97Pathways in cancer_Homo sapiens_hsa052000.61904666
98N-Glycan biosynthesis_Homo sapiens_hsa005100.59188855
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58894294
100Choline metabolism in cancer_Homo sapiens_hsa052310.58130478
101AMPK signaling pathway_Homo sapiens_hsa041520.57658705
102Pyruvate metabolism_Homo sapiens_hsa006200.57506890
103Platelet activation_Homo sapiens_hsa046110.57415910
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.56682324
105GnRH signaling pathway_Homo sapiens_hsa049120.55706199
106TGF-beta signaling pathway_Homo sapiens_hsa043500.55586587
107Prolactin signaling pathway_Homo sapiens_hsa049170.54676040
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54559148
109Viral myocarditis_Homo sapiens_hsa054160.54230859
110Long-term potentiation_Homo sapiens_hsa047200.54140786
111Amoebiasis_Homo sapiens_hsa051460.54068952
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53071327
113Lysine degradation_Homo sapiens_hsa003100.51709160
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51670715
115Phenylalanine metabolism_Homo sapiens_hsa003600.51279579
116Insulin signaling pathway_Homo sapiens_hsa049100.51007108
117Rap1 signaling pathway_Homo sapiens_hsa040150.50743392
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50582184
119Fanconi anemia pathway_Homo sapiens_hsa034600.50465220
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49194282
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48721177
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.48266862
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47258074
124Hepatitis B_Homo sapiens_hsa051610.46605593
125Wnt signaling pathway_Homo sapiens_hsa043100.45910485
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45024417
127Melanogenesis_Homo sapiens_hsa049160.44577006
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44468806
129Influenza A_Homo sapiens_hsa051640.44365473
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44175934
131Melanoma_Homo sapiens_hsa052180.40161160
132B cell receptor signaling pathway_Homo sapiens_hsa046620.40018809
133Purine metabolism_Homo sapiens_hsa002300.38497276
134Herpes simplex infection_Homo sapiens_hsa051680.37592276

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