EIF4G1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.54410681
2nuclear pore organization (GO:0006999)4.32889226
3regulation of translational fidelity (GO:0006450)4.28683839
4pre-miRNA processing (GO:0031054)4.27312563
5folic acid-containing compound biosynthetic process (GO:0009396)4.01012122
6regulation of translational termination (GO:0006449)3.95681783
7hemidesmosome assembly (GO:0031581)3.94067316
8heterochromatin organization (GO:0070828)3.89848473
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74930710
10proline biosynthetic process (GO:0006561)3.70987467
11desmosome organization (GO:0002934)3.67407381
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.63997996
13protein retention in ER lumen (GO:0006621)3.58220895
14protein localization to endosome (GO:0036010)3.58006993
15regulation of hippo signaling (GO:0035330)3.52923187
16NLS-bearing protein import into nucleus (GO:0006607)3.42705143
17DNA unwinding involved in DNA replication (GO:0006268)3.41448291
18chromosome condensation (GO:0030261)3.39327913
19protein complex localization (GO:0031503)3.36634735
20activation of Rac GTPase activity (GO:0032863)3.35722882
21regulation of mammary gland epithelial cell proliferation (GO:0033599)3.35319656
22negative regulation of cell size (GO:0045792)3.35000586
23peptidyl-lysine dimethylation (GO:0018027)3.34434392
24cellular protein complex localization (GO:0034629)3.28224627
25regulation of fatty acid beta-oxidation (GO:0031998)3.24771960
26hippo signaling (GO:0035329)3.24285744
27mRNA stabilization (GO:0048255)3.18047335
28RNA stabilization (GO:0043489)3.18047335
29paraxial mesoderm development (GO:0048339)3.17489416
30positive regulation of histone deacetylation (GO:0031065)3.15557781
31glucocorticoid receptor signaling pathway (GO:0042921)3.14877572
32adherens junction assembly (GO:0034333)3.14739305
33mitotic sister chromatid segregation (GO:0000070)3.13860556
34regulation of glucose import in response to insulin stimulus (GO:2001273)3.12350670
35regulation of posttranscriptional gene silencing (GO:0060147)3.11378450
36regulation of gene silencing by miRNA (GO:0060964)3.11378450
37regulation of gene silencing by RNA (GO:0060966)3.11378450
38pore complex assembly (GO:0046931)3.11145348
39maternal placenta development (GO:0001893)3.09841776
40regulation of NFAT protein import into nucleus (GO:0051532)3.07339783
41protein localization to kinetochore (GO:0034501)3.05846978
42polarized epithelial cell differentiation (GO:0030859)3.05286413
43regulation of RNA export from nucleus (GO:0046831)3.04037253
44mitotic nuclear envelope disassembly (GO:0007077)3.03725885
45plasma membrane repair (GO:0001778)3.01486167
46regulation of cholesterol homeostasis (GO:2000188)3.00130603
47insulin-like growth factor receptor signaling pathway (GO:0048009)2.99610774
48protein localization to microtubule (GO:0035372)2.99601524
49basement membrane organization (GO:0071711)2.99537603
50protein export from nucleus (GO:0006611)2.97663459
51skin morphogenesis (GO:0043589)2.95516686
52nuclear envelope disassembly (GO:0051081)2.94532427
53membrane disassembly (GO:0030397)2.94532427
54positive regulation of SMAD protein import into nucleus (GO:0060391)2.92157687
55IMP biosynthetic process (GO:0006188)2.91569057
56establishment of apical/basal cell polarity (GO:0035089)2.89912991
57epithelial cell differentiation involved in prostate gland development (GO:0060742)2.89741508
58regulation of histone H3-K27 methylation (GO:0061085)2.88687909
59positive regulation of fatty acid beta-oxidation (GO:0032000)2.88545320
60spliceosomal tri-snRNP complex assembly (GO:0000244)2.87930071
61low-density lipoprotein particle clearance (GO:0034383)2.87430449
62COPI coating of Golgi vesicle (GO:0048205)2.86225076
63Golgi transport vesicle coating (GO:0048200)2.86225076
64DNA packaging (GO:0006323)2.85306332
65histone H2A monoubiquitination (GO:0035518)2.83933867
66focal adhesion assembly (GO:0048041)2.82875475
67cell-substrate adherens junction assembly (GO:0007045)2.82875475
68activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.82760351
69dosage compensation (GO:0007549)2.81883028
70cytoplasmic mRNA processing body assembly (GO:0033962)2.81607147
71regulation of early endosome to late endosome transport (GO:2000641)2.81422057
72chromatin assembly (GO:0031497)2.80357244
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.79605689
74cell-substrate junction assembly (GO:0007044)2.79102300
75positive regulation of nuclease activity (GO:0032075)2.77554068
76protein localization to chromosome, centromeric region (GO:0071459)2.72772495
77negative regulation of fatty acid transport (GO:2000192)2.70673959
78mitotic sister chromatid cohesion (GO:0007064)2.70325156
79pentose-phosphate shunt (GO:0006098)2.70015201
80COPII vesicle coating (GO:0048208)2.69729978
81negative regulation of histone methylation (GO:0031061)2.67747989
82lysine metabolic process (GO:0006553)2.67504711
83lysine catabolic process (GO:0006554)2.67504711
844-hydroxyproline metabolic process (GO:0019471)2.66872561
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66492658
86DNA duplex unwinding (GO:0032508)2.65976815
87cell adhesion mediated by integrin (GO:0033627)2.65644593
88DNA replication initiation (GO:0006270)2.65601109
89vesicle coating (GO:0006901)2.65384521
90regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64775970
91epithelial cell-cell adhesion (GO:0090136)2.64696342
92branching involved in mammary gland duct morphogenesis (GO:0060444)2.64290914
93DNA geometric change (GO:0032392)2.62657706
94tetrahydrofolate metabolic process (GO:0046653)2.61523842
95glycine metabolic process (GO:0006544)2.60688382
96trophectodermal cell differentiation (GO:0001829)2.60423093
97regulation of SMAD protein import into nucleus (GO:0060390)2.60244998
98formation of translation preinitiation complex (GO:0001731)2.59693067
99protein maturation by protein folding (GO:0022417)2.59569959
100peptidyl-arginine omega-N-methylation (GO:0035247)2.59233790
101ER-nucleus signaling pathway (GO:0006984)2.59210823
102apoptotic process involved in morphogenesis (GO:0060561)2.59193172
103cellular response to epidermal growth factor stimulus (GO:0071364)2.58952103
104mitotic G1 DNA damage checkpoint (GO:0031571)2.58386119
105DNA conformation change (GO:0071103)2.58379289
106nucleosome disassembly (GO:0006337)2.56644694
107protein-DNA complex disassembly (GO:0032986)2.56644694
108corticosteroid receptor signaling pathway (GO:0031958)2.55580884
109regulation of mitotic spindle organization (GO:0060236)2.55358538
110embryonic process involved in female pregnancy (GO:0060136)2.55280718
111semaphorin-plexin signaling pathway (GO:0071526)2.54337708
112positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.54313652
113DNA strand elongation involved in DNA replication (GO:0006271)2.53926505
114DNA strand elongation (GO:0022616)2.53630780
115regulation of sister chromatid cohesion (GO:0007063)2.52738171
116regulation of nuclease activity (GO:0032069)2.52302966
117IMP metabolic process (GO:0046040)2.52266666
118regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50498502
119nuclear envelope organization (GO:0006998)2.50110727
120positive regulation of DNA-dependent DNA replication (GO:2000105)2.49279391
121regulation of nucleobase-containing compound transport (GO:0032239)2.48772625
122dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48771976
123cell migration involved in sprouting angiogenesis (GO:0002042)2.48375110
124sister chromatid segregation (GO:0000819)2.47577551
125apoptotic cell clearance (GO:0043277)2.46981673
126ribosome assembly (GO:0042255)2.46931345
127endoplasmic reticulum unfolded protein response (GO:0030968)2.44759116
128glucose catabolic process (GO:0006007)2.44445604
129blood vessel endothelial cell migration (GO:0043534)2.44229620
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.43279675
131gastrulation with mouth forming second (GO:0001702)2.42805178
132alpha-linolenic acid metabolic process (GO:0036109)2.42009211
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41536647
134regulation of tight junction assembly (GO:2000810)2.41316650
135embryonic foregut morphogenesis (GO:0048617)2.40964081
136regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.40357284
137intracellular estrogen receptor signaling pathway (GO:0030520)2.40282916
138mitotic chromosome condensation (GO:0007076)2.40135629
139cellular response to unfolded protein (GO:0034620)2.39883907
140establishment of monopolar cell polarity (GO:0061162)2.38849290
141establishment or maintenance of monopolar cell polarity (GO:0061339)2.38849290
142negative regulation of lipid transport (GO:0032369)2.37934035
143NADPH regeneration (GO:0006740)2.36881188
144response to epidermal growth factor (GO:0070849)2.36820968
145regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.36146427
146nuclear envelope reassembly (GO:0031468)2.35026185
147chaperone-mediated protein complex assembly (GO:0051131)2.33319924
148positive regulation of glycogen biosynthetic process (GO:0045725)2.33306240
1492-oxoglutarate metabolic process (GO:0006103)2.33035318
150regulation of spindle organization (GO:0090224)2.31500683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.50887697
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.04035036
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.69273370
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.48231049
5MYC_22102868_ChIP-Seq_BL_Human2.98854234
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.97554316
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.83985371
8CLOCK_20551151_ChIP-Seq_293T_Human2.58302645
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49679722
10ZNF263_19887448_ChIP-Seq_K562_Human2.38202240
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19342014
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.10258274
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00409338
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93866741
15AR_21909140_ChIP-Seq_LNCAP_Human1.93676070
16* RXR_22158963_ChIP-Seq_LIVER_Mouse1.92637800
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.87280749
18KDM2B_26808549_Chip-Seq_DND41_Human1.85026510
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80569742
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.79924183
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.79495805
22TCF7_22412390_ChIP-Seq_EML_Mouse1.78808047
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78129491
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76583347
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76501926
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73991378
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73122652
28ATF3_27146783_Chip-Seq_COLON_Human1.71705051
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71576924
30* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70115939
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66787012
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65489043
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63477657
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62711523
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.62361512
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61793890
37* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61436491
38VDR_21846776_ChIP-Seq_THP-1_Human1.61374590
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.61081881
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60843283
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60225573
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60070543
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58516537
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54505542
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52773854
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51657046
47RACK7_27058665_Chip-Seq_MCF-7_Human1.51285059
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48755430
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47513285
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47422721
51* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46821202
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46057014
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42858658
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42269823
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39028448
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.38004024
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36803639
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34417483
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34391806
60* XRN2_22483619_ChIP-Seq_HELA_Human1.32977733
61* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32321192
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30557343
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30461594
64* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30393402
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30268862
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30061929
67CHD1_26751641_Chip-Seq_LNCaP_Human1.30055368
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29735222
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29504908
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29241196
71LXR_22292898_ChIP-Seq_THP-1_Human1.28904657
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28120488
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27364479
74NCOR1_26117541_ChIP-Seq_K562_Human1.27152984
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27039267
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24422630
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24281842
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24221360
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23875638
80GATA6_25053715_ChIP-Seq_YYC3_Human1.23361427
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.21681580
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18925095
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18604740
84* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18225344
85CREB1_26743006_Chip-Seq_LNCaP_Human1.16760493
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16366295
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14189743
88UTX_26944678_Chip-Seq_JUKART_Human1.13845738
89FOXO3_23340844_ChIP-Seq_DLD1_Human1.13146176
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13083011
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13083011
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12261555
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11844450
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.11472255
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11109885
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09799126
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08858663
98TP53_22127205_ChIP-Seq_IMR90_Human1.08468075
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08415595
100MAF_26560356_Chip-Seq_TH1_Human1.07920226
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.07912949
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07675433
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.07595524
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06965464
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06815745
106NANOG_21062744_ChIP-ChIP_HESCs_Human1.05135123
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02960237
108KDM2B_26808549_Chip-Seq_K562_Human1.02768279
109* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02686315
110KDM5A_27292631_Chip-Seq_BREAST_Human1.02607422
111THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01565389
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00570470
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.00139818
114UBF1/2_26484160_Chip-Seq_HMECs_Human0.99220764
115CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98774694
116BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97368111
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96891813
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96681092
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96607491
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96171828
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95964333
122CIITA_25753668_ChIP-Seq_RAJI_Human0.95830954
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95580146
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93667013
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92999941
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.92637783
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.92637783
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92528680
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92123674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.93858534
2MP0010352_gastrointestinal_tract_polyps3.35578872
3MP0005451_abnormal_body_composition2.91041744
4MP0005076_abnormal_cell_differentiation2.80753061
5MP0010234_abnormal_vibrissa_follicle2.50034137
6MP0008438_abnormal_cutaneous_collagen2.35050126
7MP0003566_abnormal_cell_adhesion2.26459598
8MP0000537_abnormal_urethra_morphology2.09557037
9MP0003300_gastrointestinal_ulcer1.91859604
10MP0009053_abnormal_anal_canal1.91619808
11MP0004185_abnormal_adipocyte_glucose1.90736486
12MP0004197_abnormal_fetal_growth/weight/1.81749383
13MP0010307_abnormal_tumor_latency1.80367759
14MP0002877_abnormal_melanocyte_morpholog1.77758471
15MP0005257_abnormal_intraocular_pressure1.77216116
16MP0001730_embryonic_growth_arrest1.76785896
17MP0000733_abnormal_muscle_development1.75047492
18MP0002139_abnormal_hepatobiliary_system1.74593348
19MP0005360_urolithiasis1.71280020
20MP0004858_abnormal_nervous_system1.68638625
21MP0001849_ear_inflammation1.63731465
22MP0005275_abnormal_skin_tensile1.60288327
23MP0005666_abnormal_adipose_tissue1.57074090
24MP0005623_abnormal_meninges_morphology1.54754499
25MP0003252_abnormal_bile_duct1.54678627
26MP0003123_paternal_imprinting1.53426370
27MP0000579_abnormal_nail_morphology1.53327607
28MP0005380_embryogenesis_phenotype1.51765712
29MP0001672_abnormal_embryogenesis/_devel1.51765712
30MP0002088_abnormal_embryonic_growth/wei1.51670605
31MP0003111_abnormal_nucleus_morphology1.51630435
32MP0003984_embryonic_growth_retardation1.51350188
33MP0002086_abnormal_extraembryonic_tissu1.51125602
34MP0004233_abnormal_muscle_weight1.48560634
35MP0002084_abnormal_developmental_patter1.47723895
36MP0005409_darkened_coat_color1.46589422
37MP0005023_abnormal_wound_healing1.45864844
38MP0003941_abnormal_skin_development1.45464627
39MP0003283_abnormal_digestive_organ1.41385586
40MP0008057_abnormal_DNA_replication1.38088566
41MP0004957_abnormal_blastocyst_morpholog1.36329878
42MP0009672_abnormal_birth_weight1.35290651
43MP0000678_abnormal_parathyroid_gland1.35216768
44MP0004272_abnormal_basement_membrane1.34447078
45MP0005375_adipose_tissue_phenotype1.31852578
46MP0008932_abnormal_embryonic_tissue1.31624090
47MP0003567_abnormal_fetal_cardiomyocyte1.31404697
48MP0010030_abnormal_orbit_morphology1.30916961
49MP0000350_abnormal_cell_proliferation1.30599050
50MP0001697_abnormal_embryo_size1.30390996
51MP0005365_abnormal_bile_salt1.28933762
52MP0002085_abnormal_embryonic_tissue1.26423363
53MP0006054_spinal_hemorrhage1.25011858
54MP0010630_abnormal_cardiac_muscle1.24571377
55MP0003115_abnormal_respiratory_system1.24560559
56MP0004087_abnormal_muscle_fiber1.23750077
57MP0001661_extended_life_span1.23153011
58MP0009840_abnormal_foam_cell1.20729314
59MP0001216_abnormal_epidermal_layer1.20356389
60MP0000762_abnormal_tongue_morphology1.18535027
61MP0002080_prenatal_lethality1.18333752
62MP0004130_abnormal_muscle_cell1.18256561
63MP0008961_abnormal_basal_metabolism1.17634043
64MP0004264_abnormal_extraembryonic_tissu1.17573705
65MP0000003_abnormal_adipose_tissue1.17268758
66MP0003077_abnormal_cell_cycle1.16609714
67MP0009278_abnormal_bone_marrow1.16455584
68MP0005085_abnormal_gallbladder_physiolo1.16154782
69MP0003091_abnormal_cell_migration1.15208605
70MP0002269_muscular_atrophy1.14620859
71MP0000428_abnormal_craniofacial_morphol1.14346456
72MP0005670_abnormal_white_adipose1.14276724
73MP0003119_abnormal_digestive_system1.14015970
74MP0000467_abnormal_esophagus_morphology1.13655704
75MP0001915_intracranial_hemorrhage1.13334817
76MP0008260_abnormal_autophagy1.13297095
77MP0004084_abnormal_cardiac_muscle1.12787265
78MP0005058_abnormal_lysosome_morphology1.11615238
79MP0002009_preneoplasia1.11236412
80MP0005621_abnormal_cell_physiology1.10834915
81MP0003806_abnormal_nucleotide_metabolis1.09369230
82MP0004782_abnormal_surfactant_physiolog1.09137539
83MP0009703_decreased_birth_body1.05440085
84MP0008007_abnormal_cellular_replicative1.04323503
85MP0005187_abnormal_penis_morphology1.03907725
86MP0005083_abnormal_biliary_tract1.02827303
87MP0003279_aneurysm1.00869716
88MP0002098_abnormal_vibrissa_morphology1.00589833
89MP0010329_abnormal_lipoprotein_level0.99410229
90MP0000750_abnormal_muscle_regeneration0.99389043
91MP0002925_abnormal_cardiovascular_devel0.98942025
92MP0002697_abnormal_eye_size0.98826666
93MP0003693_abnormal_embryo_hatching0.98341484
94MP0002396_abnormal_hematopoietic_system0.97831252
95MP0000627_abnormal_mammary_gland0.97326500
96MP0010094_abnormal_chromosome_stability0.97160105
97MP0001346_abnormal_lacrimal_gland0.94005693
98MP0003191_abnormal_cellular_cholesterol0.93514949
99MP0003221_abnormal_cardiomyocyte_apopto0.93303440
100MP0003950_abnormal_plasma_membrane0.92962955
101MP0003315_abnormal_perineum_morphology0.92377841
102MP0000266_abnormal_heart_morphology0.91838615
103MP0000609_abnormal_liver_physiology0.91795462
104MP0000747_muscle_weakness0.89790714
105MP0002092_abnormal_eye_morphology0.89255127
106MP0002060_abnormal_skin_morphology0.88394953
107MP0000377_abnormal_hair_follicle0.88102089
108MP0000858_altered_metastatic_potential0.86752194
109MP0002166_altered_tumor_susceptibility0.84766910
110MP0002896_abnormal_bone_mineralization0.84599081
111MP0002111_abnormal_tail_morphology0.84054526
112MP0003890_abnormal_embryonic-extraembry0.82678745
113MP0003935_abnormal_craniofacial_develop0.81888256
114MP0009931_abnormal_skin_appearance0.81224273
115MP0004808_abnormal_hematopoietic_stem0.80867790
116MP0005384_cellular_phenotype0.79947630
117MP0000598_abnormal_liver_morphology0.79368612
118MP0000751_myopathy0.79319731
119MP0003453_abnormal_keratinocyte_physiol0.79185325
120MP0006138_congestive_heart_failure0.78748938
121MP0002249_abnormal_larynx_morphology0.78620255
122MP0008770_decreased_survivor_rate0.78280390
123MP0003385_abnormal_body_wall0.77788912
124MP0001881_abnormal_mammary_gland0.76214349
125MP0000566_synostosis0.75827024
126MP0003942_abnormal_urinary_system0.75789904
127MP0002128_abnormal_blood_circulation0.75157633
128MP0003303_peritoneal_inflammation0.74356761
129MP0000534_abnormal_ureter_morphology0.74106912
130MP0002796_impaired_skin_barrier0.73321302
131MP0000759_abnormal_skeletal_muscle0.73189486
132MP0001348_abnormal_lacrimal_gland0.72973340
133MP0002089_abnormal_postnatal_growth/wei0.71624828
134MP0005330_cardiomyopathy0.68798009
135MP0005501_abnormal_skin_physiology0.68341648
136MP0002234_abnormal_pharynx_morphology0.68081295

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.41074469
2Cerebral aneurysm (HP:0004944)3.33144438
3Shallow orbits (HP:0000586)3.19978148
4Increased connective tissue (HP:0009025)2.99750916
5Distal lower limb amyotrophy (HP:0008944)2.97442727
6Broad face (HP:0000283)2.89451661
7Hyperacusis (HP:0010780)2.83152564
8Ankle contracture (HP:0006466)2.82613158
9Short nail (HP:0001799)2.62275789
10Premature rupture of membranes (HP:0001788)2.61476279
11Short 4th metacarpal (HP:0010044)2.54299998
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54299998
13Ependymoma (HP:0002888)2.49490153
14Subacute progressive viral hepatitis (HP:0006572)2.48895348
15Pseudobulbar signs (HP:0002200)2.48198003
16Upper limb amyotrophy (HP:0009129)2.45503202
17Distal upper limb amyotrophy (HP:0007149)2.45503202
18Mitral valve prolapse (HP:0001634)2.45310070
19Asymmetry of the thorax (HP:0001555)2.44576739
20Ulnar bowing (HP:0003031)2.43678899
21Increased density of long bones (HP:0006392)2.43251608
22Advanced eruption of teeth (HP:0006288)2.42042747
23Vertebral compression fractures (HP:0002953)2.40711928
24Abnormality of the distal phalanges of the toes (HP:0010182)2.40496451
25Distal lower limb muscle weakness (HP:0009053)2.39448572
26Aneurysm (HP:0002617)2.38196291
27Difficulty climbing stairs (HP:0003551)2.37454689
28Deep venous thrombosis (HP:0002625)2.36573562
29Trismus (HP:0000211)2.34974737
30Spastic diplegia (HP:0001264)2.34620427
31Abnormality of the 4th metacarpal (HP:0010012)2.34080598
32Back pain (HP:0003418)2.33895198
33Ankyloglossia (HP:0010296)2.33551174
34Astrocytoma (HP:0009592)2.31695221
35Abnormality of the astrocytes (HP:0100707)2.31695221
36Hand muscle atrophy (HP:0009130)2.31547938
37Abnormality of the distal phalanx of the thumb (HP:0009617)2.30546862
38Fragile skin (HP:0001030)2.30494197
39Sparse lateral eyebrow (HP:0005338)2.30376249
40Lymphangioma (HP:0100764)2.28286333
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.26262748
42Spinal rigidity (HP:0003306)2.25453596
43Renal duplication (HP:0000075)2.22965248
44Lower limb amyotrophy (HP:0007210)2.22201756
45Natal tooth (HP:0000695)2.22034012
46Renovascular hypertension (HP:0100817)2.18681729
47Bowel diverticulosis (HP:0005222)2.18648130
48Abnormality of oral frenula (HP:0000190)2.17801100
49Long palpebral fissure (HP:0000637)2.14945881
50Selective tooth agenesis (HP:0001592)2.14366330
51Rectal prolapse (HP:0002035)2.14209006
52Bladder diverticulum (HP:0000015)2.14097196
53Hyporeflexia of lower limbs (HP:0002600)2.12511540
54Enlarged penis (HP:0000040)2.12413070
55Elfin facies (HP:0004428)2.11174708
56Right ventricular cardiomyopathy (HP:0011663)2.10826232
57Abnormality of the calcaneus (HP:0008364)2.10402192
58Abnormality of the lower motor neuron (HP:0002366)2.10352973
59Difficulty running (HP:0009046)2.10008591
60Deviation of the thumb (HP:0009603)2.09049466
61Progressive muscle weakness (HP:0003323)2.06705362
62Abnormality of the Achilles tendon (HP:0005109)2.06598176
63Disproportionate tall stature (HP:0001519)2.06526380
64Genu recurvatum (HP:0002816)2.04639718
65Dilatation of the ascending aorta (HP:0005111)2.04547914
66Achilles tendon contracture (HP:0001771)2.04299824
67Macroorchidism (HP:0000053)1.98828646
68Aortic aneurysm (HP:0004942)1.98789624
69Radial bowing (HP:0002986)1.97739367
70Patellar dislocation (HP:0002999)1.96268862
71Fibroma (HP:0010614)1.92649864
72Heterotopia (HP:0002282)1.91350456
73Wormian bones (HP:0002645)1.89830180
74Proximal placement of thumb (HP:0009623)1.89022641
75Abnormal ossification of hand bones (HP:0005921)1.88790102
76Cervical subluxation (HP:0003308)1.87401788
77Elbow flexion contracture (HP:0002987)1.87107158
78Septate vagina (HP:0001153)1.86977920
79Turricephaly (HP:0000262)1.86832310
80Fibrous tissue neoplasm (HP:0012316)1.86369364
81Increased nuchal translucency (HP:0010880)1.85630773
82Scapular winging (HP:0003691)1.85099259
83Deviation of the hallux (HP:0010051)1.84974497
84Exercise-induced muscle cramps (HP:0003710)1.83716755
85Hallux valgus (HP:0001822)1.83201040
86Abnormality of carpal bone ossification (HP:0006257)1.83026746
87Type 1 muscle fiber predominance (HP:0003803)1.82920478
88Increased mean platelet volume (HP:0011877)1.82701399
89Wrist flexion contracture (HP:0001239)1.81584725
90Blue sclerae (HP:0000592)1.80103256
91Thin bony cortex (HP:0002753)1.79649112
92Long toe (HP:0010511)1.78988434
93Broad metatarsal (HP:0001783)1.78176905
94Bowed forearm bones (HP:0003956)1.76482160
95Bowing of the arm (HP:0006488)1.76482160
96Gastrointestinal carcinoma (HP:0002672)1.74322560
97Malignant gastrointestinal tract tumors (HP:0006749)1.74322560
98Abnormality of skeletal muscle fiber size (HP:0012084)1.73199714
99Peritonitis (HP:0002586)1.72980793
100Spinal cord lesions (HP:0100561)1.72722510
101Syringomyelia (HP:0003396)1.72722510
102Long eyelashes (HP:0000527)1.72703666
103High pitched voice (HP:0001620)1.72686404
104Urethral obstruction (HP:0000796)1.71794180
105Biliary tract neoplasm (HP:0100574)1.71128541
106Broad thumb (HP:0011304)1.70472665
107Abnormality of the phalanges of the hallux (HP:0010057)1.70232924
108Insomnia (HP:0100785)1.69605358
109Abnormality of the umbilical cord (HP:0010881)1.69596808
110Increased variability in muscle fiber diameter (HP:0003557)1.69546422
111Metaphyseal cupping (HP:0003021)1.68482059
112Pelvic girdle muscle weakness (HP:0003749)1.67946300
113Abnormality of monocarboxylic acid metabolism (HP:0010996)1.67595590
114Biconcave vertebral bodies (HP:0004586)1.67243465
115Xanthomatosis (HP:0000991)1.66178616
116Progressive hearing impairment (HP:0001730)1.65706419
117Abnormality of the acetabulum (HP:0003170)1.65430353
118Mildly elevated creatine phosphokinase (HP:0008180)1.64715628
119Angiofibromas (HP:0010615)1.64661646
120Adenoma sebaceum (HP:0009720)1.64661646
121Abnormal foot bone ossification (HP:0010675)1.64568515
122Abnormality of the salivary glands (HP:0010286)1.63196244
123Camptodactyly of toe (HP:0001836)1.62642645
124Missing ribs (HP:0000921)1.62510727
125Flat acetabular roof (HP:0003180)1.62199017
126Dysmetric saccades (HP:0000641)1.61715048
127Dislocated radial head (HP:0003083)1.61532052
128Persistence of primary teeth (HP:0006335)1.61513948
129Myocardial infarction (HP:0001658)1.61467383
130Arnold-Chiari malformation (HP:0002308)1.60759864
131Myoglobinuria (HP:0002913)1.60190618
132Generalized amyotrophy (HP:0003700)1.60005139
133Mitral regurgitation (HP:0001653)1.59954362
134Esophageal varix (HP:0002040)1.59895357
135Relative macrocephaly (HP:0004482)1.58604278
136Glioma (HP:0009733)1.57465194
137Abnormality of nail color (HP:0100643)1.57229034
138Overriding aorta (HP:0002623)1.57078213
139Arterial tortuosity (HP:0005116)1.56893521
140Spinal cord compression (HP:0002176)1.56681064
141Abnormality of the peritoneum (HP:0002585)1.56661698
142Aortic dissection (HP:0002647)1.56506478
143Osteolytic defects of the hand bones (HP:0009699)1.56325375
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.56325375
145Vertebral arch anomaly (HP:0008438)1.56245895
146Deep philtrum (HP:0002002)1.55963378
147Hypopigmentation of the fundus (HP:0007894)1.54810168
148Neonatal death (HP:0003811)1.54325680
149Limb-girdle muscle weakness (HP:0003325)1.53639617
150Atrophic scars (HP:0001075)1.53515536
151Reticulocytosis (HP:0001923)1.53312341
152Skull defect (HP:0001362)1.52937409
153Pointed chin (HP:0000307)1.52476788
154Abnormality of the thoracic spine (HP:0100711)1.50912198
155Midface retrusion (HP:0011800)1.49733065
156Milia (HP:0001056)1.48072921
157Impaired pain sensation (HP:0007328)1.47649787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.59591089
2PKN24.18129567
3SMG13.91366472
4EEF2K3.57712253
5TTN3.26293043
6CDK123.25877411
7MAP3K102.81538071
8IRAK32.68852246
9LATS12.50270266
10MST1R2.30494350
11PTK62.12080988
12RIPK12.12047004
13PDGFRA2.10485289
14SIK12.06007258
15PRPF4B2.02679371
16NEK11.77953326
17ERN11.74434550
18SCYL21.74061317
19EPHA21.69166441
20LATS21.64792426
21CDC71.63918936
22ICK1.60252682
23NEK21.53475244
24ALK1.53334321
25CAMK1D1.50717028
26* MTOR1.49565094
27NME21.44740785
28RPS6KB21.42191243
29BMX1.37899931
30CDK61.27929384
31LRRK21.25646225
32PAK41.21696390
33CAMK1G1.21681809
34DDR21.21073852
35STK101.20521885
36CDK41.17649376
37PASK1.14085455
38FGFR41.13795151
39EIF2AK11.12073934
40STK31.10516279
41FLT31.07909366
42FGFR11.01965620
43PTK21.01781341
44TTK1.00559474
45BRD40.98047286
46BUB10.96586072
47NTRK10.92655224
48MAP3K90.92035789
49ARAF0.89132377
50PDGFRB0.86010792
51TAOK20.84515338
52ERBB40.83116903
53MAP2K30.83054546
54DMPK0.81340470
55PRKD30.80633112
56TSSK60.79335378
57MET0.79113547
58MAP3K70.77106632
59TAOK10.76382179
60TGFBR10.75809122
61RET0.75770370
62PBK0.70682711
63SRPK10.70415534
64CHEK10.69600944
65MAP3K130.65582781
66TYRO30.65564565
67LMTK20.65000038
68PDK30.64658196
69PDK40.64658196
70CDK80.64294363
71CHEK20.62476616
72BRAF0.61959248
73FGFR30.61478553
74RPS6KA20.60896380
75PRKD20.60487058
76FER0.59507067
77RPS6KA40.59232251
78* MAP3K80.59136350
79KSR20.58310241
80PIM20.58120674
81AKT20.58103571
82* PAK20.55938810
83CDK70.55150988
84AURKA0.54220136
85AURKB0.52814609
86BCKDK0.50646236
87TRPM70.50370693
88* CDK20.49726026
89PDPK10.49448727
90CLK10.48791749
91MAP3K30.48152332
92ATR0.47732543
93ILK0.47581792
94TAF10.47103970
95TESK10.46889726
96CSNK1E0.46667999
97CSNK1D0.46624617
98EPHB20.46238566
99EPHB10.45526318
100BRSK10.44823744
101FGFR20.44148035
102ATM0.43949270
103PAK30.41362419
104MAP2K20.41277068
105RAF10.41021390
106RPS6KA10.40611554
107STK40.40414494
108MOS0.40382147
109MARK20.39955737
110IRAK20.39675550
111MAP3K10.39584292
112MAPKAPK30.38847121
113MAPK110.38258544
114STK380.37989298
115NEK90.37938392
116STK38L0.37046709
117FRK0.36834893
118WEE10.36353215
119ERBB20.36323014
120DYRK1B0.36039543
121CDC42BPA0.35707010
122GSK3A0.35678984
123PRKCI0.35284774
124CDK90.35262981
125PLK10.35202675
126SIK20.35086132
127PRKCH0.34781202
128RPS6KC10.33967843
129RPS6KL10.33967843
130PRKAA10.33528827
131TESK20.33163785
132JAK20.32669909
133PAK60.32505596
134CDK10.32132963
135PRKG20.31856264
136* PRKDC0.31763304
137MAPK10.31269395
138MELK0.31101881

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.65376044
2Nitrogen metabolism_Homo sapiens_hsa009102.64728163
3One carbon pool by folate_Homo sapiens_hsa006702.23064659
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21248932
5DNA replication_Homo sapiens_hsa030302.09426935
6Lysine degradation_Homo sapiens_hsa003102.05764694
7Arginine biosynthesis_Homo sapiens_hsa002201.70315980
8Selenocompound metabolism_Homo sapiens_hsa004501.69601352
9Biosynthesis of amino acids_Homo sapiens_hsa012301.66657049
10Central carbon metabolism in cancer_Homo sapiens_hsa052301.57448973
11Chronic myeloid leukemia_Homo sapiens_hsa052201.55850735
12Adherens junction_Homo sapiens_hsa045201.55823025
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54489785
14mTOR signaling pathway_Homo sapiens_hsa041501.49633996
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48309783
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47513807
17Fatty acid degradation_Homo sapiens_hsa000711.41506531
18Carbon metabolism_Homo sapiens_hsa012001.41447807
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39895477
20Small cell lung cancer_Homo sapiens_hsa052221.38232648
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38017443
22Proteoglycans in cancer_Homo sapiens_hsa052051.36953847
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34558691
24Insulin resistance_Homo sapiens_hsa049311.33427754
25MicroRNAs in cancer_Homo sapiens_hsa052061.33348625
26Focal adhesion_Homo sapiens_hsa045101.32632744
27Fructose and mannose metabolism_Homo sapiens_hsa000511.32191264
28Bladder cancer_Homo sapiens_hsa052191.31447595
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29244074
30Prion diseases_Homo sapiens_hsa050201.25885608
31Hippo signaling pathway_Homo sapiens_hsa043901.18365226
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17942101
33PPAR signaling pathway_Homo sapiens_hsa033201.15902904
34Other glycan degradation_Homo sapiens_hsa005111.14940990
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.13650686
36AMPK signaling pathway_Homo sapiens_hsa041521.13437720
37* RNA transport_Homo sapiens_hsa030131.12431323
38Fatty acid metabolism_Homo sapiens_hsa012121.11849850
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09752734
40Endometrial cancer_Homo sapiens_hsa052131.07581477
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07048304
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06856213
43ECM-receptor interaction_Homo sapiens_hsa045121.06756164
44Fatty acid biosynthesis_Homo sapiens_hsa000611.04969720
45Galactose metabolism_Homo sapiens_hsa000521.04519590
46Basal cell carcinoma_Homo sapiens_hsa052171.04442958
47Fat digestion and absorption_Homo sapiens_hsa049751.02804526
48Tryptophan metabolism_Homo sapiens_hsa003801.02079282
49N-Glycan biosynthesis_Homo sapiens_hsa005101.01645616
50ErbB signaling pathway_Homo sapiens_hsa040121.01464523
51Insulin signaling pathway_Homo sapiens_hsa049101.01015832
52mRNA surveillance pathway_Homo sapiens_hsa030150.99441812
53Bile secretion_Homo sapiens_hsa049760.98550352
54Viral carcinogenesis_Homo sapiens_hsa052030.97618792
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97178084
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.96238585
57Thyroid cancer_Homo sapiens_hsa052160.95272416
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92924093
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.92820958
60Base excision repair_Homo sapiens_hsa034100.92425961
61Glucagon signaling pathway_Homo sapiens_hsa049220.91071074
62Non-small cell lung cancer_Homo sapiens_hsa052230.90410397
63Vitamin B6 metabolism_Homo sapiens_hsa007500.89616173
64Notch signaling pathway_Homo sapiens_hsa043300.89491195
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89439282
66Cell cycle_Homo sapiens_hsa041100.89033782
67Tight junction_Homo sapiens_hsa045300.88988602
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88468683
69Propanoate metabolism_Homo sapiens_hsa006400.85488116
70Amoebiasis_Homo sapiens_hsa051460.85352880
71HTLV-I infection_Homo sapiens_hsa051660.80535354
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80240753
73Glioma_Homo sapiens_hsa052140.79647968
74Pyruvate metabolism_Homo sapiens_hsa006200.79509506
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79136531
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78732283
77Apoptosis_Homo sapiens_hsa042100.78664339
78Acute myeloid leukemia_Homo sapiens_hsa052210.77672003
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.77519475
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77317777
81Colorectal cancer_Homo sapiens_hsa052100.75162827
82Complement and coagulation cascades_Homo sapiens_hsa046100.74535851
83Pancreatic cancer_Homo sapiens_hsa052120.74123055
84Hepatitis B_Homo sapiens_hsa051610.73980920
85Mismatch repair_Homo sapiens_hsa034300.73008962
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71631649
87Nucleotide excision repair_Homo sapiens_hsa034200.71139192
88Caffeine metabolism_Homo sapiens_hsa002320.70990967
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70816615
90HIF-1 signaling pathway_Homo sapiens_hsa040660.69818847
91Starch and sucrose metabolism_Homo sapiens_hsa005000.69416310
92Prostate cancer_Homo sapiens_hsa052150.69397069
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69339346
94Shigellosis_Homo sapiens_hsa051310.69194013
95TGF-beta signaling pathway_Homo sapiens_hsa043500.66859914
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.66001435
97Renal cell carcinoma_Homo sapiens_hsa052110.65587089
98Type II diabetes mellitus_Homo sapiens_hsa049300.65355174
99Inositol phosphate metabolism_Homo sapiens_hsa005620.65145993
100Hepatitis C_Homo sapiens_hsa051600.64793101
101Melanoma_Homo sapiens_hsa052180.64563551
102p53 signaling pathway_Homo sapiens_hsa041150.64503088
103Non-homologous end-joining_Homo sapiens_hsa034500.64252367
104Dilated cardiomyopathy_Homo sapiens_hsa054140.63662382
105Prolactin signaling pathway_Homo sapiens_hsa049170.62279180
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.62117056
107Pentose phosphate pathway_Homo sapiens_hsa000300.61966047
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61922453
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.60440349
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59606033
111VEGF signaling pathway_Homo sapiens_hsa043700.59497253
112* Viral myocarditis_Homo sapiens_hsa054160.59090519
113Protein digestion and absorption_Homo sapiens_hsa049740.56874158
114Vibrio cholerae infection_Homo sapiens_hsa051100.56557707
115Phenylalanine metabolism_Homo sapiens_hsa003600.56493083
116Estrogen signaling pathway_Homo sapiens_hsa049150.56127992
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54109043
118Hedgehog signaling pathway_Homo sapiens_hsa043400.53637095
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53362712
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53304645
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52785777
122Choline metabolism in cancer_Homo sapiens_hsa052310.52742311
123Butanoate metabolism_Homo sapiens_hsa006500.52347180
124Sulfur relay system_Homo sapiens_hsa041220.51898566
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51222855
126Dorso-ventral axis formation_Homo sapiens_hsa043200.50223735
127GnRH signaling pathway_Homo sapiens_hsa049120.50133576
128FoxO signaling pathway_Homo sapiens_hsa040680.50117977
129Pathways in cancer_Homo sapiens_hsa052000.49645560
130Spliceosome_Homo sapiens_hsa030400.49398216
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46727806

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