EIF4ENIF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)7.21959978
2regulation of acrosome reaction (GO:0060046)7.14379235
3regulation of female gonad development (GO:2000194)6.49270374
4regulation of meiosis I (GO:0060631)5.67383727
5DNA methylation involved in gamete generation (GO:0043046)5.50337075
6oocyte development (GO:0048599)5.31831025
7reproduction (GO:0000003)4.68784589
8nuclear pore complex assembly (GO:0051292)4.55601892
9meiotic cell cycle (GO:0051321)4.54494864
10nuclear pore organization (GO:0006999)4.48801229
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.45173460
12histone H3-K4 trimethylation (GO:0080182)4.43656050
13positive regulation of humoral immune response (GO:0002922)4.40769846
14mitotic chromosome condensation (GO:0007076)4.32838662
15mitotic sister chromatid cohesion (GO:0007064)4.32397344
16mitotic metaphase plate congression (GO:0007080)4.31685254
17protein localization to kinetochore (GO:0034501)4.31292740
18histone H3-K36 demethylation (GO:0070544)4.22889429
19female gamete generation (GO:0007292)4.17919149
20mitotic nuclear envelope disassembly (GO:0007077)4.08911909
21regulation of DNA methylation (GO:0044030)4.05715660
22acrosome reaction (GO:0007340)4.02957669
23kinetochore organization (GO:0051383)4.01066796
24binding of sperm to zona pellucida (GO:0007339)4.00248322
25male meiosis (GO:0007140)3.97111709
26metaphase plate congression (GO:0051310)3.94876154
27protein kinase C signaling (GO:0070528)3.94394728
28mitotic sister chromatid segregation (GO:0000070)3.90696154
29protein localization to chromosome, centromeric region (GO:0071459)3.90293746
30sperm-egg recognition (GO:0035036)3.85584106
31interkinetic nuclear migration (GO:0022027)3.84774965
32DNA replication initiation (GO:0006270)3.82851064
33synapsis (GO:0007129)3.81715706
34positive regulation of histone H3-K4 methylation (GO:0051571)3.80477557
35membrane disassembly (GO:0030397)3.79877623
36nuclear envelope disassembly (GO:0051081)3.79877623
37meiotic chromosome segregation (GO:0045132)3.76520678
38regulation of histone H3-K4 methylation (GO:0051569)3.74477834
39regulation of sister chromatid cohesion (GO:0007063)3.71299563
40sister chromatid segregation (GO:0000819)3.70413104
41negative regulation of histone methylation (GO:0031061)3.69648992
42establishment of chromosome localization (GO:0051303)3.66738603
43kinetochore assembly (GO:0051382)3.63762878
44DNA replication checkpoint (GO:0000076)3.60215529
45regulation of spindle organization (GO:0090224)3.55897648
46DNA unwinding involved in DNA replication (GO:0006268)3.53628103
47protein localization to chromosome (GO:0034502)3.53125893
48regulation of histone methylation (GO:0031060)3.52315259
49DNA synthesis involved in DNA repair (GO:0000731)3.51694652
50negative regulation of reproductive process (GO:2000242)3.51470440
51pore complex assembly (GO:0046931)3.49120799
52negative regulation of cAMP-mediated signaling (GO:0043951)3.47464127
53DNA strand elongation involved in DNA replication (GO:0006271)3.47433175
54pre-miRNA processing (GO:0031054)3.45038589
55protein K6-linked ubiquitination (GO:0085020)3.43441456
56telomere maintenance via semi-conservative replication (GO:0032201)3.43259008
57DNA replication-independent nucleosome organization (GO:0034724)3.41314295
58DNA replication-independent nucleosome assembly (GO:0006336)3.41314295
59single fertilization (GO:0007338)3.41055351
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.40501033
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.40501033
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.40501033
63chromatin remodeling at centromere (GO:0031055)3.40335645
64fertilization (GO:0009566)3.40252937
65CENP-A containing nucleosome assembly (GO:0034080)3.39817671
66attachment of spindle microtubules to kinetochore (GO:0008608)3.39248128
67histone H3-K4 methylation (GO:0051568)3.38595102
68positive regulation of chromosome segregation (GO:0051984)3.36678452
69telomere maintenance via recombination (GO:0000722)3.36602893
70DNA strand elongation (GO:0022616)3.34877017
71dosage compensation (GO:0007549)3.34039589
72histone lysine demethylation (GO:0070076)3.32755331
73spermatid development (GO:0007286)3.32210106
74histone demethylation (GO:0016577)3.31932408
75centriole replication (GO:0007099)3.31496836
76histone H2A monoubiquitination (GO:0035518)3.31462795
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.29422487
78chromosome segregation (GO:0007059)3.27026264
79retinal cone cell development (GO:0046549)3.26969730
80mitotic recombination (GO:0006312)3.25823415
81DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.24845559
82cell-cell recognition (GO:0009988)3.24496273
83regulation of calcium ion-dependent exocytosis (GO:0017158)3.21924988
84histone H3-K9 demethylation (GO:0033169)3.20600971
85monoubiquitinated protein deubiquitination (GO:0035520)3.19997816
86peptidyl-lysine trimethylation (GO:0018023)3.19947228
87gene silencing (GO:0016458)3.19679969
88sister chromatid cohesion (GO:0007062)3.19548738
89male meiosis I (GO:0007141)3.18665996
90N-terminal protein amino acid acetylation (GO:0006474)3.17673842
91positive regulation of meiosis (GO:0045836)3.17496416
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16668047
93DNA duplex unwinding (GO:0032508)3.16626591
94DNA geometric change (GO:0032392)3.16601663
95chromatin assembly or disassembly (GO:0006333)3.14971941
96spindle checkpoint (GO:0031577)3.13856583
97DNA damage response, signal transduction resulting in transcription (GO:0042772)3.13621765
98regulation of chromosome segregation (GO:0051983)3.13224455
99gene silencing by RNA (GO:0031047)3.11518978
100DNA methylation or demethylation (GO:0044728)3.11441350
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10658470
102histone lysine methylation (GO:0034968)3.10470825
103regulation of nuclear cell cycle DNA replication (GO:0033262)3.10404449
104negative regulation of histone modification (GO:0031057)3.09969481
105regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.08535309
106regulation of telomere maintenance via telomerase (GO:0032210)3.05066830
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04806784
108protein dealkylation (GO:0008214)3.04626111
109protein demethylation (GO:0006482)3.04626111
110regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03402405
111regulation of mitotic spindle organization (GO:0060236)3.02944059
112L-fucose catabolic process (GO:0042355)3.02627430
113fucose catabolic process (GO:0019317)3.02627430
114L-fucose metabolic process (GO:0042354)3.02627430
115chromosome organization involved in meiosis (GO:0070192)3.01224623
116nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.01018661
117negative regulation of chromosome segregation (GO:0051985)3.00553283
118regulation of histone H3-K9 methylation (GO:0051570)3.00126511
119IMP biosynthetic process (GO:0006188)3.00081177
120positive regulation of meiotic cell cycle (GO:0051446)2.99467460
121histone exchange (GO:0043486)2.99079499
122positive regulation of DNA-dependent DNA replication (GO:2000105)2.99022938
123positive regulation of histone methylation (GO:0031062)2.98587826
124telomere maintenance via telomere lengthening (GO:0010833)2.98583056
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97954473
126replication fork processing (GO:0031297)2.97152784
127spindle assembly checkpoint (GO:0071173)2.97073684
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95916878
129negative regulation of sister chromatid segregation (GO:0033046)2.95916878
130negative regulation of mitotic sister chromatid separation (GO:2000816)2.95916878
131negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95916878
132positive regulation of gene expression, epigenetic (GO:0045815)2.94325484
133regulation of sister chromatid segregation (GO:0033045)2.94291036
134regulation of mitotic sister chromatid separation (GO:0010965)2.94291036
135regulation of mitotic sister chromatid segregation (GO:0033047)2.94291036
136stress granule assembly (GO:0034063)2.94196940
137negative regulation of chromatin modification (GO:1903309)2.93665093
138sperm motility (GO:0030317)2.92744476
139mitotic spindle assembly checkpoint (GO:0007094)2.92561178
140nuclear envelope organization (GO:0006998)2.91851850
141DNA methylation (GO:0006306)2.91509095
142DNA alkylation (GO:0006305)2.91509095
143histone H3-K9 methylation (GO:0051567)2.90999237
144mitotic spindle checkpoint (GO:0071174)2.90907580
145ATP-dependent chromatin remodeling (GO:0043044)2.90823424
146histone H2A acetylation (GO:0043968)2.89104237
147regulation of DNA damage checkpoint (GO:2000001)2.88565064
148nucleotide-excision repair, DNA gap filling (GO:0006297)2.88209484
149meiotic nuclear division (GO:0007126)2.86988044
150DNA replication-dependent nucleosome assembly (GO:0006335)2.86902850
151DNA replication-dependent nucleosome organization (GO:0034723)2.86902850
152calcium ion-dependent exocytosis (GO:0017156)2.86891106
153peptidyl-lysine methylation (GO:0018022)2.86305691
154heterochromatin organization (GO:0070828)2.86193856
155mismatch repair (GO:0006298)2.84149075
156negative regulation of organelle assembly (GO:1902116)2.84043378
157somatic hypermutation of immunoglobulin genes (GO:0016446)2.83906098
158somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83906098
159piRNA metabolic process (GO:0034587)2.83311457
160vesicle transport along microtubule (GO:0047496)2.82136843
161negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.81967048
162negative regulation of DNA-templated transcription, elongation (GO:0032785)2.81967048
163IMP metabolic process (GO:0046040)2.80586837
164protein polyglutamylation (GO:0018095)2.79020374
165centriole assembly (GO:0098534)2.75154097
166germ cell development (GO:0007281)2.75041368
167DNA double-strand break processing (GO:0000729)2.74842624
168regulation of steroid hormone secretion (GO:2000831)2.72881827
169positive regulation of catecholamine secretion (GO:0033605)2.71807227
170synaptonemal complex assembly (GO:0007130)2.64602935
171DNA damage induced protein phosphorylation (GO:0006975)2.63902565
172protein K11-linked deubiquitination (GO:0035871)2.63851805
173microtubule severing (GO:0051013)2.62308921
174regulation of hypersensitivity (GO:0002883)2.60823515
175histone H3-K9 modification (GO:0061647)2.60224472
176phosphorelay signal transduction system (GO:0000160)2.59199653
177regulation of chromatin silencing (GO:0031935)2.57955475
178DNA modification (GO:0006304)2.56831223
179regulation of RNA export from nucleus (GO:0046831)2.54045870
180oogenesis (GO:0048477)2.53836781
181synaptonemal complex organization (GO:0070193)2.52987447
182spermatid nucleus differentiation (GO:0007289)2.51766761
183histone methylation (GO:0016571)2.49648587
184single strand break repair (GO:0000012)2.45650515
185cytoplasmic mRNA processing body assembly (GO:0033962)2.43629891
186microtubule nucleation (GO:0007020)2.41110761
187meiotic cell cycle process (GO:1903046)2.41065518
188TOR signaling (GO:0031929)2.36879253
189glycine transport (GO:0015816)2.33705103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human9.63315694
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.97994534
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.35614029
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.20019679
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.18083705
6E2F1_21310950_ChIP-Seq_MCF-7_Human3.07868323
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.06053288
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.04840912
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87570541
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.74204498
11GBX2_23144817_ChIP-Seq_PC3_Human2.73179355
12MYC_22102868_ChIP-Seq_BL_Human2.68594462
13AR_21909140_ChIP-Seq_LNCAP_Human2.68413806
14* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.63185973
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51708839
16ZNF274_21170338_ChIP-Seq_K562_Hela2.45646839
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43151180
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23786723
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22519430
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.22090134
21CIITA_25753668_ChIP-Seq_RAJI_Human2.19905355
22IGF1R_20145208_ChIP-Seq_DFB_Human2.19735089
23* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.18515584
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18438480
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15079865
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.15079865
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10380157
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.09533369
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08903085
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04019584
31E2F7_22180533_ChIP-Seq_HELA_Human11.2985336
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95753262
33* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89859109
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86595102
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84350721
36* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83327021
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79072466
38STAT3_23295773_ChIP-Seq_U87_Human1.75340351
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70811683
40AR_21572438_ChIP-Seq_LNCaP_Human1.70584541
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69360754
42ER_23166858_ChIP-Seq_MCF-7_Human1.68444214
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67036130
44CBP_20019798_ChIP-Seq_JUKART_Human1.67036130
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.64982215
46TCF4_23295773_ChIP-Seq_U87_Human1.63525819
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63145399
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62566973
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62114930
50* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61863389
51XRN2_22483619_ChIP-Seq_HELA_Human1.60643460
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60426187
53FOXP3_21729870_ChIP-Seq_TREG_Human1.56670240
54VDR_23849224_ChIP-Seq_CD4+_Human1.54600800
55VDR_22108803_ChIP-Seq_LS180_Human1.54466525
56SMAD4_21799915_ChIP-Seq_A2780_Human1.53823011
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49256537
58DROSHA_22980978_ChIP-Seq_HELA_Human1.46852065
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45989787
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45340280
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44799452
62* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43640614
63KDM5A_27292631_Chip-Seq_BREAST_Human1.43413770
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.43214317
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.43100422
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42142733
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39870754
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39772042
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35992757
70REST_21632747_ChIP-Seq_MESCs_Mouse1.35904708
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34674153
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34556788
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32859661
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32630529
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32083943
76ELK1_19687146_ChIP-ChIP_HELA_Human1.30969183
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30208287
78EWS_26573619_Chip-Seq_HEK293_Human1.29613083
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.28880130
80GABP_19822575_ChIP-Seq_HepG2_Human1.27438922
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.26848518
82* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26657884
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26401107
84* SMAD4_21741376_ChIP-Seq_EPCs_Human1.26306336
85RUNX2_22187159_ChIP-Seq_PCA_Human1.25920906
86IRF1_19129219_ChIP-ChIP_H3396_Human1.25378343
87AR_25329375_ChIP-Seq_VCAP_Human1.25092229
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24968246
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24642101
90P300_19829295_ChIP-Seq_ESCs_Human1.24461025
91TTF2_22483619_ChIP-Seq_HELA_Human1.24320471
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.23257318
93* DCP1A_22483619_ChIP-Seq_HELA_Human1.22426617
94* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20447257
95* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20357865
96WDR5_24793694_ChIP-Seq_LNCAP_Human1.19836912
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18771641
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18078305
99* SCL_19346495_ChIP-Seq_HPC-7_Human1.17982998
100VDR_21846776_ChIP-Seq_THP-1_Human1.16935902
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15020686
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.14650302
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14162455
104TCF7_22412390_ChIP-Seq_EML_Mouse1.14018904
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.13986914
106AHR_22903824_ChIP-Seq_MCF-7_Human1.13010917
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12973432
108SMRT_27268052_Chip-Seq_Bcells_Human1.10529223
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10371189
110* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09660021
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08559081
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07742786
113* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07076732
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06729945
115* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05755523
116AR_19668381_ChIP-Seq_PC3_Human1.05707801
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.05269374
118OCT4_19829295_ChIP-Seq_ESCs_Human1.04428842
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04322781
120GATA1_26923725_Chip-Seq_HPCs_Mouse1.04110053
121JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03988231
122THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03964882
123MYC_18940864_ChIP-ChIP_HL60_Human1.03699186
124NANOG_21062744_ChIP-ChIP_HESCs_Human1.03683173
125PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03161330
126E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01965914
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01538598
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00668913
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00546520
130FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00078934
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99463400
132FUS_26573619_Chip-Seq_HEK293_Human0.97251155
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96978943
134MYB_26560356_Chip-Seq_TH2_Human0.96493270
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95700250
136* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95178240
137KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93732679
138ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93529199
139UTX_26944678_Chip-Seq_JUKART_Human0.93495330
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93441460
141HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93015541
142OCT1_27270436_Chip-Seq_PROSTATE_Human0.93009856
143* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92717155
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92333081
145TP53_22573176_ChIP-Seq_HFKS_Human0.91459497
146GATA3_21878914_ChIP-Seq_MCF-7_Human0.91278588
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.90602804
148RXR_22108803_ChIP-Seq_LS180_Human0.90315258
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90210582
150HOXB7_26014856_ChIP-Seq_BT474_Human0.89872311
151BCAT_22108803_ChIP-Seq_LS180_Human0.89824544
152MYB_26560356_Chip-Seq_TH1_Human0.89735020
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89688915
154GATA3_26560356_Chip-Seq_TH1_Human0.89688285
155ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89401924
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89075537
157* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88400208
158CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88193161
159GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88081447
160ERA_21632823_ChIP-Seq_H3396_Human0.87884879
161LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87580019
162STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86559703
163BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.86373213
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86135089
165SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84228946
166FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83029009
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.82774324
168SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82526167
169* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82469727
170NANOG_20526341_ChIP-Seq_ESCs_Human0.82232964
171SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82038715
172* SPI1_23547873_ChIP-Seq_NB4_Human0.81978148
173TBL1_22424771_ChIP-Seq_293T_Human0.81867864
174OCT4_20526341_ChIP-Seq_ESCs_Human0.81850401
175FLI1_21867929_ChIP-Seq_TH2_Mouse0.81773149
176TCF4_22108803_ChIP-Seq_LS180_Human0.81714590
177FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81651956
178IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79872526
179TFEB_21752829_ChIP-Seq_HELA_Human0.79766105
180CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79240634
181MAF_26560356_Chip-Seq_TH1_Human0.76006049
182CHD1_26751641_Chip-Seq_LNCaP_Human0.75694393
183KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74818246
184MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74002704
185STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73469891
186ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.71375275
187FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70939925
188POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.70424841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.20672281
2MP0010094_abnormal_chromosome_stability4.08250766
3MP0003111_abnormal_nucleus_morphology3.77972842
4MP0008057_abnormal_DNA_replication3.70649362
5MP0003077_abnormal_cell_cycle3.50829631
6MP0008877_abnormal_DNA_methylation3.22074370
7MP0004957_abnormal_blastocyst_morpholog3.09875890
8MP0008058_abnormal_DNA_repair3.00291532
9MP0005410_abnormal_fertilization2.84985910
10MP0002396_abnormal_hematopoietic_system2.60190224
11MP0008007_abnormal_cellular_replicative2.49362935
12MP0003123_paternal_imprinting2.40978612
13MP0003121_genomic_imprinting2.39708656
14MP0003787_abnormal_imprinting2.36933648
15MP0001984_abnormal_olfaction2.36100113
16MP0004808_abnormal_hematopoietic_stem2.18994281
17MP0002138_abnormal_hepatobiliary_system2.07878872
18MP0000350_abnormal_cell_proliferation2.07426965
19MP0010352_gastrointestinal_tract_polyps2.04797061
20MP0010307_abnormal_tumor_latency2.02631254
21MP0003698_abnormal_male_reproductive1.99753721
22MP0005646_abnormal_pituitary_gland1.99185029
23MP0010030_abnormal_orbit_morphology1.91860415
24MP0001730_embryonic_growth_arrest1.89777031
25MP0000015_abnormal_ear_pigmentation1.87814885
26MP0008932_abnormal_embryonic_tissue1.87363584
27MP0005076_abnormal_cell_differentiation1.71219244
28MP0005380_embryogenesis_phenotype1.69589732
29MP0001672_abnormal_embryogenesis/_devel1.69589732
30MP0003718_maternal_effect1.64924363
31MP0005395_other_phenotype1.64641469
32MP0002160_abnormal_reproductive_system1.64029001
33MP0003763_abnormal_thymus_physiology1.63731924
34MP0001968_abnormal_touch/_nociception1.62921185
35MP0001697_abnormal_embryo_size1.58967927
36MP0002161_abnormal_fertility/fecundity1.56092034
37MP0000631_abnormal_neuroendocrine_gland1.54966750
38MP0003984_embryonic_growth_retardation1.54502951
39MP0001501_abnormal_sleep_pattern1.54193514
40MP0002085_abnormal_embryonic_tissue1.53388864
41MP0002102_abnormal_ear_morphology1.51018053
42MP0001119_abnormal_female_reproductive1.50815690
43MP0002088_abnormal_embryonic_growth/wei1.49550500
44MP0000490_abnormal_crypts_of1.47410509
45MP0002084_abnormal_developmental_patter1.46759142
46MP0003786_premature_aging1.43916177
47MP0002210_abnormal_sex_determination1.42069111
48MP0000566_synostosis1.40659748
49MP0004084_abnormal_cardiac_muscle1.39874160
50MP0003635_abnormal_synaptic_transmissio1.39714567
51MP0002272_abnormal_nervous_system1.38260209
52MP0001502_abnormal_circadian_rhythm1.37620401
53MP0003567_abnormal_fetal_cardiomyocyte1.37258022
54MP0002086_abnormal_extraembryonic_tissu1.36573439
55MP0009745_abnormal_behavioral_response1.36449423
56MP0001545_abnormal_hematopoietic_system1.35689383
57MP0005397_hematopoietic_system_phenotyp1.35689383
58MP0004859_abnormal_synaptic_plasticity1.33994534
59MP0002019_abnormal_tumor_incidence1.33856049
60MP0000427_abnormal_hair_cycle1.31610909
61MP0004381_abnormal_hair_follicle1.28452322
62MP0002080_prenatal_lethality1.26707014
63MP0009046_muscle_twitch1.26543873
64MP0002163_abnormal_gland_morphology1.25727059
65MP0000313_abnormal_cell_death1.25711708
66MP0002735_abnormal_chemical_nociception1.24923449
67MP0001929_abnormal_gametogenesis1.23534188
68MP0000703_abnormal_thymus_morphology1.22901596
69MP0002398_abnormal_bone_marrow1.21845988
70MP0004197_abnormal_fetal_growth/weight/1.21522798
71MP0000653_abnormal_sex_gland1.16216602
72MP0005645_abnormal_hypothalamus_physiol1.14230223
73MP0002877_abnormal_melanocyte_morpholog1.13421270
74MP0002249_abnormal_larynx_morphology1.12708418
75MP0002063_abnormal_learning/memory/cond1.12607502
76MP0003890_abnormal_embryonic-extraembry1.11979810
77MP0005551_abnormal_eye_electrophysiolog1.08886566
78MP0001915_intracranial_hemorrhage1.08492378
79MP0009333_abnormal_splenocyte_physiolog1.07426183
80MP0003699_abnormal_female_reproductive1.07152487
81MP0006292_abnormal_olfactory_placode1.06826922
82MP0001486_abnormal_startle_reflex1.06210313
83MP0001293_anophthalmia1.06032543
84MP0003937_abnormal_limbs/digits/tail_de1.05834623
85MP0003183_abnormal_peptide_metabolism1.05653176
86MP0002572_abnormal_emotion/affect_behav1.05512923
87MP0005174_abnormal_tail_pigmentation1.04118017
88MP0010368_abnormal_lymphatic_system1.03235449
89MP0001145_abnormal_male_reproductive1.02439502
90MP0003879_abnormal_hair_cell1.01074831
91MP0003136_yellow_coat_color1.00425236
92MP0005451_abnormal_body_composition1.00127700
93MP0000569_abnormal_digit_pigmentation0.97418177
94MP0005647_abnormal_sex_gland0.97372775
95MP0002064_seizures0.96899716
96MP0003315_abnormal_perineum_morphology0.94517363
97MP0009697_abnormal_copulation0.94344453
98MP0005310_abnormal_salivary_gland0.93675782
99MP0006276_abnormal_autonomic_nervous0.93655370
100MP0004924_abnormal_behavior0.93367452
101MP0005386_behavior/neurological_phenoty0.93367452
102MP0002722_abnormal_immune_system0.92462605
103MP0008789_abnormal_olfactory_epithelium0.92413785
104MP0003943_abnormal_hepatobiliary_system0.92380313
105MP0004264_abnormal_extraembryonic_tissu0.92034816
106MP0009278_abnormal_bone_marrow0.90996060
107MP0004811_abnormal_neuron_physiology0.89673666
108MP0001986_abnormal_taste_sensitivity0.89666663
109MP0002067_abnormal_sensory_capabilities0.89147558
110MP0001835_abnormal_antigen_presentation0.88540851
111MP0000689_abnormal_spleen_morphology0.87515261
112MP0000383_abnormal_hair_follicle0.85704090
113MP0003941_abnormal_skin_development0.85526645
114MP0003935_abnormal_craniofacial_develop0.84127039
115MP0009703_decreased_birth_body0.82463921
116MP0009672_abnormal_birth_weight0.81599727
117MP0004215_abnormal_myocardial_fiber0.81523377
118MP0006054_spinal_hemorrhage0.81245318
119MP0001790_abnormal_immune_system0.77951344
120MP0005387_immune_system_phenotype0.77951344
121MP0002006_tumorigenesis0.77028570
122MP0005075_abnormal_melanosome_morpholog0.77028494
123MP0002429_abnormal_blood_cell0.76913822
124MP0000432_abnormal_head_morphology0.76628979
125MP0002925_abnormal_cardiovascular_devel0.75986724
126MP0008995_early_reproductive_senescence0.75553425
127MP0005389_reproductive_system_phenotype0.74554760
128MP0001286_abnormal_eye_development0.74004276
129MP0005621_abnormal_cell_physiology0.73752590
130MP0002095_abnormal_skin_pigmentation0.73368351
131MP0000749_muscle_degeneration0.72883662
132MP0002233_abnormal_nose_morphology0.72784881
133MP0004036_abnormal_muscle_relaxation0.71985653
134MP0002837_dystrophic_cardiac_calcinosis0.71844292
135MP0001919_abnormal_reproductive_system0.71662117
136MP0001188_hyperpigmentation0.71518924
137MP0002938_white_spotting0.71180701
138MP0000716_abnormal_immune_system0.70873146
139MP0008961_abnormal_basal_metabolism0.69829820
140MP0002557_abnormal_social/conspecific_i0.69766898
141MP0003828_pulmonary_edema0.69738165
142MP0002736_abnormal_nociception_after0.68317183
143MP0005384_cellular_phenotype0.67960280
144MP0005023_abnormal_wound_healing0.66162962
145MP0001963_abnormal_hearing_physiology0.65547352
146MP0001800_abnormal_humoral_immune0.64829822
147MP0002653_abnormal_ependyma_morphology0.64512962
148MP0002127_abnormal_cardiovascular_syste0.64067614
149MP0002229_neurodegeneration0.64027239
150MP0000266_abnormal_heart_morphology0.63922403
151MP0000733_abnormal_muscle_development0.63487396
152MP0003566_abnormal_cell_adhesion0.63357102
153MP0002092_abnormal_eye_morphology0.63309789
154MP0001905_abnormal_dopamine_level0.62998210
155MP0002111_abnormal_tail_morphology0.62984237
156MP0003942_abnormal_urinary_system0.62604412
157MP0003646_muscle_fatigue0.60324611
158MP0002932_abnormal_joint_morphology0.60219489
159MP0005499_abnormal_olfactory_system0.60114611
160MP0005394_taste/olfaction_phenotype0.60114611
161MP0005253_abnormal_eye_physiology0.58395469

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.67050022
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.41975376
3Birth length less than 3rd percentile (HP:0003561)4.27359269
4Abnormality of the fingertips (HP:0001211)3.83966035
5Chronic hepatic failure (HP:0100626)3.57922591
6Oligodactyly (hands) (HP:0001180)3.46556845
7Patellar aplasia (HP:0006443)3.32555620
8Abnormality of chromosome stability (HP:0003220)3.23902804
9Gaze-evoked nystagmus (HP:0000640)3.22949174
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.09977366
11Volvulus (HP:0002580)3.09787274
12Aplasia/Hypoplasia of the patella (HP:0006498)3.01743976
13Ectopic kidney (HP:0000086)3.01324570
14Myelodysplasia (HP:0002863)2.99602687
15Meckel diverticulum (HP:0002245)2.93919883
16Acute myeloid leukemia (HP:0004808)2.93790756
17Clumsiness (HP:0002312)2.90902943
18Abnormality of the preputium (HP:0100587)2.89247585
19Protruding tongue (HP:0010808)2.88351015
20Anterior segment dysgenesis (HP:0007700)2.84094654
21Tubulointerstitial nephritis (HP:0001970)2.82341379
22Abnormality of the ileum (HP:0001549)2.77925334
23Medulloblastoma (HP:0002885)2.77728702
24Increased nuchal translucency (HP:0010880)2.68859736
25Abnormality of the anterior horn cell (HP:0006802)2.64255267
26Degeneration of anterior horn cells (HP:0002398)2.64255267
27Duodenal stenosis (HP:0100867)2.64157691
28Small intestinal stenosis (HP:0012848)2.64157691
29Papillary thyroid carcinoma (HP:0002895)2.61671665
30Deep palmar crease (HP:0006191)2.60712954
31Fair hair (HP:0002286)2.59841100
32Febrile seizures (HP:0002373)2.52194900
33Rhabdomyosarcoma (HP:0002859)2.51840879
34Clubbing of toes (HP:0100760)2.51599410
35Long eyelashes (HP:0000527)2.49360044
36Hypoplastic iliac wings (HP:0002866)2.48476310
37Deep philtrum (HP:0002002)2.48325767
38Abnormality of the labia minora (HP:0012880)2.44931453
39Abnormality of the columella (HP:0009929)2.44298329
40Abnormality of the carotid arteries (HP:0005344)2.42945175
41Urethral obstruction (HP:0000796)2.42387333
42Focal motor seizures (HP:0011153)2.42016215
43Postural instability (HP:0002172)2.41497094
44Breast hypoplasia (HP:0003187)2.39181435
45Progressive cerebellar ataxia (HP:0002073)2.39075380
46Oligodactyly (HP:0012165)2.37483767
47Inability to walk (HP:0002540)2.31706690
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27698072
49Hypoplasia of the fovea (HP:0007750)2.24000572
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.24000572
51High anterior hairline (HP:0009890)2.22598650
52Impulsivity (HP:0100710)2.20659834
53Atonic seizures (HP:0010819)2.19665700
54Progressive inability to walk (HP:0002505)2.19600935
55Short 4th metacarpal (HP:0010044)2.18253835
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.18253835
57Aplasia/Hypoplasia of the sternum (HP:0006714)2.18245087
58Abnormality of the duodenum (HP:0002246)2.17791141
59Nephroblastoma (Wilms tumor) (HP:0002667)2.15521944
60Shawl scrotum (HP:0000049)2.14662497
61Hyperventilation (HP:0002883)2.14534673
62Broad-based gait (HP:0002136)2.12736550
63Sloping forehead (HP:0000340)2.11742763
64Deviation of the thumb (HP:0009603)2.10394901
65Attenuation of retinal blood vessels (HP:0007843)2.10370953
66Abnormality of chromosome segregation (HP:0002916)2.08467375
67Selective tooth agenesis (HP:0001592)2.08455298
68Abdominal situs inversus (HP:0003363)2.07576168
69Abnormality of abdominal situs (HP:0011620)2.07576168
70Cafe-au-lait spot (HP:0000957)2.07113041
71Skull defect (HP:0001362)2.06473945
72Facial hemangioma (HP:0000329)2.06428526
73Prominent nose (HP:0000448)2.06307690
74Optic nerve coloboma (HP:0000588)2.05525584
75Aplastic anemia (HP:0001915)2.04604908
76Cerebellar dysplasia (HP:0007033)2.04310369
77Acute lymphatic leukemia (HP:0006721)2.03697633
78Molar tooth sign on MRI (HP:0002419)2.03131539
79Abnormality of midbrain morphology (HP:0002418)2.03131539
80Poor eye contact (HP:0000817)2.02575245
81Embryonal renal neoplasm (HP:0011794)2.01859228
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01803005
83Lip pit (HP:0100267)2.01796289
84Abnormality of the intervertebral disk (HP:0005108)2.01341038
85Proximal placement of thumb (HP:0009623)2.01049336
86Atresia of the external auditory canal (HP:0000413)2.00441415
87Abnormal number of incisors (HP:0011064)1.99623000
88Focal seizures (HP:0007359)1.98864546
89High pitched voice (HP:0001620)1.97407174
90Abnormal lung lobation (HP:0002101)1.97238050
91Dialeptic seizures (HP:0011146)1.96918837
92Sandal gap (HP:0001852)1.96747400
93Neoplasm of the oral cavity (HP:0100649)1.95867189
94Short thumb (HP:0009778)1.93070002
95Generalized hypopigmentation of hair (HP:0011358)1.92665635
96Bone marrow hypocellularity (HP:0005528)1.92532077
97Abnormality of DNA repair (HP:0003254)1.91322278
98Abnormality of the incisor (HP:0000676)1.88580315
99Carpal bone hypoplasia (HP:0001498)1.88122733
100Hypoplastic labia majora (HP:0000059)1.87715633
101Spinal cord lesions (HP:0100561)1.87561554
102Syringomyelia (HP:0003396)1.87561554
103Hyperkalemia (HP:0002153)1.86836184
104Dysdiadochokinesis (HP:0002075)1.85662825
105Ependymoma (HP:0002888)1.83663785
106Increased circulating renin level (HP:0000848)1.83608857
107Colon cancer (HP:0003003)1.83469424
108Absent speech (HP:0001344)1.83449122
109Enlarged penis (HP:0000040)1.82590179
110Bile duct proliferation (HP:0001408)1.81876181
111Abnormal biliary tract physiology (HP:0012439)1.81876181
112Absent radius (HP:0003974)1.81291267
113Abnormality of the renal medulla (HP:0100957)1.81128263
114Abnormality of the fovea (HP:0000493)1.80330884
115Heterotopia (HP:0002282)1.79815532
116Abnormality of incisor morphology (HP:0011063)1.79594784
117Infertility (HP:0000789)1.79415356
118IgA deficiency (HP:0002720)1.79255083
119Gonadotropin excess (HP:0000837)1.77775191
120Absence seizures (HP:0002121)1.77646361
121Neoplasm of striated muscle (HP:0009728)1.77556993
122Cutaneous melanoma (HP:0012056)1.76776778
123Trigonocephaly (HP:0000243)1.76719193
124Spinal muscular atrophy (HP:0007269)1.76636762
125Type II lissencephaly (HP:0007260)1.76629098
126Truncal obesity (HP:0001956)1.75261984
127Basal cell carcinoma (HP:0002671)1.75243653
128Genetic anticipation (HP:0003743)1.74117725
129Diastasis recti (HP:0001540)1.74102107
130Abnormality of the labia majora (HP:0012881)1.72715895
131Premature ovarian failure (HP:0008209)1.72387336
132Gastrointestinal carcinoma (HP:0002672)1.72086859
133Malignant gastrointestinal tract tumors (HP:0006749)1.72086859
134Abnormality of lateral ventricle (HP:0030047)1.71421622
13511 pairs of ribs (HP:0000878)1.70666532
136Polydipsia (HP:0001959)1.69959841
137Abnormal drinking behavior (HP:0030082)1.69959841
138Absent forearm bone (HP:0003953)1.69339924
139Aplasia involving forearm bones (HP:0009822)1.69339924
140Absent thumb (HP:0009777)1.67907392
141Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.67636635
142Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66776206
143Resting tremor (HP:0002322)1.65988523
144Blepharitis (HP:0000498)1.65899957
145Sparse scalp hair (HP:0002209)1.65724521
146Leiomyosarcoma (HP:0100243)1.65569113
147Uterine leiomyosarcoma (HP:0002891)1.65569113
148Pancreatic cysts (HP:0001737)1.65527792
149Congenital sensorineural hearing impairment (HP:0008527)1.65307731
150Congenital stationary night blindness (HP:0007642)1.65128598
151Dysmetric saccades (HP:0000641)1.64954516
152Intellectual disability, progressive (HP:0006887)1.64904694
153Widely spaced teeth (HP:0000687)1.64507481
154Cutis marmorata (HP:0000965)1.64397290
155Hypoplastic nipples (HP:0002557)1.64339215
156Horizontal nystagmus (HP:0000666)1.64139648
157Broad palm (HP:0001169)1.64093307
158Abnormality of the aortic arch (HP:0012303)1.63297175
159Nephronophthisis (HP:0000090)1.63215819
160Abnormality of cochlea (HP:0000375)1.62565472
161Renovascular hypertension (HP:0100817)1.62458266
162Supernumerary spleens (HP:0009799)1.62233524
163Thyroid carcinoma (HP:0002890)1.59699082
164Abnormality of the renal collecting system (HP:0004742)1.57522448
165Tracheoesophageal fistula (HP:0002575)1.56768418
166Transitional cell carcinoma of the bladder (HP:0006740)1.54297987
167Thrombocytosis (HP:0001894)1.54163497
168Slender long bone (HP:0003100)1.53716735
169Capillary hemangiomas (HP:0005306)1.53252184
170Obsessive-compulsive behavior (HP:0000722)1.52880425
171Squamous cell carcinoma (HP:0002860)1.52826364
172Hyperacusis (HP:0010780)1.52298013
173Duplicated collecting system (HP:0000081)1.51994710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.41866502
2PINK14.07093838
3EEF2K3.36199503
4CDK123.25574673
5FRK3.10142779
6ACVR1B2.93108100
7TTK2.88019655
8MAP3K92.85515030
9NEK22.81265731
10MARK32.79169564
11LATS12.60095978
12PLK42.50746473
13MKNK22.49344294
14MAP3K132.43817019
15MKNK12.20716942
16CAMK1G1.94817110
17CDK81.93184508
18BRSK21.87726205
19PLK11.81648404
20BUB11.80964161
21RPS6KB21.80314263
22WEE11.78832078
23CHEK21.78272282
24MAP3K61.77081151
25SIK21.72195382
26SRPK11.71156222
27STK31.69435239
28ATR1.66433994
29WNK11.66194141
30CDK41.65338793
31TLK11.62401198
32BRD41.60521941
33STK38L1.56740412
34STK101.54473242
35PLK31.52508511
36AURKB1.51216746
37MELK1.50594684
38CAMK1D1.48823679
39TGFBR11.47343270
40CDK71.47103546
41TNIK1.39978787
42CHEK11.39133185
43PNCK1.37540393
44STK381.34709181
45STK41.32505097
46MAPK131.30868833
47BRAF1.29810673
48LATS21.29323268
49NTRK21.25127980
50RPS6KA41.25075317
51MAP4K11.22418314
52NEK61.20720768
53RAF11.20528661
54TAOK31.20463418
55PASK1.18248073
56CDK91.17492329
57ATM1.17008919
58JAK31.15897499
59TNK21.15149242
60DMPK1.08981100
61ARAF1.07621306
62EIF2AK11.07394053
63OBSCN1.04794224
64MAP3K81.04495852
65PKN21.04074819
66CSNK1A1L1.04041756
67PIM11.03863327
68FGFR31.01203072
69CSNK1G11.00892598
70MAP3K101.00247408
71TAOK10.98771665
72STK240.98629156
73STK390.96503990
74BRSK10.95944201
75CSNK1G30.94369302
76CDK60.92127479
77SGK4940.92062437
78SGK2230.92062437
79VRK10.91831348
80TAOK20.91359996
81* CDK20.91045708
82RIPK10.90399079
83NTRK30.90171622
84PIK3CG0.89988687
85TRPM70.86629398
86MARK20.86001194
87CHUK0.83509392
88NEK10.83207385
89PRKCQ0.82968342
90CAMK40.82594652
91PKN10.77553389
92MAP2K60.75116323
93CSNK1G20.74696110
94PDK10.73596626
95CDK10.72293646
96TSSK60.71461052
97KIT0.71265878
98ERBB40.70828109
99KSR10.69514590
100MTOR0.68820300
101OXSR10.67562842
102MAP2K30.65697587
103CAMK10.64741719
104CDK50.64351705
105MAP4K20.63571591
106ALK0.63239365
107SGK20.62564163
108PTK2B0.62326185
109AURKA0.61813863
110NUAK10.61803522
111DYRK30.61038554
112SGK30.57815100
113MARK10.57673713
114WNK40.57491933
115MAP3K70.56503397
116ADRBK20.55859869
117PRKAA10.54671902
118ZAK0.53816383
119FLT30.52713714
120MAPK120.51458961
121NLK0.50642379
122MAPKAPK30.50115526
123AKT30.49815247
124TXK0.48901531
125CDK190.48457838
126PDPK10.48305175
127INSRR0.47345382
128* MAPK140.47054775
129BMPR1B0.45939011
130PRKCI0.45674320
131SIK30.45399369
132FGFR20.45144703
133BTK0.44188774
134MUSK0.44150229
135MAPKAPK50.43645893
136MAPK100.43347871
137AKT10.43179820
138TYK20.42747970
139CCNB10.42550739
140PRKD30.42270758
141MAPK110.39878401
142CSNK1D0.38422489
143KSR20.36410268
144MAP3K50.35564836
145IKBKE0.34455262
146NEK90.34265155
147* MAPK10.33665135
148TRIB30.33039679
149EIF2AK20.32859894
150RPS6KB10.32754490
151EIF2AK30.31111266
152* GSK3B0.30503804
153CDK30.28316666

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.01325493
2Mismatch repair_Homo sapiens_hsa034303.53830695
3Cell cycle_Homo sapiens_hsa041103.34861380
4Base excision repair_Homo sapiens_hsa034103.09464639
5RNA transport_Homo sapiens_hsa030132.70096182
6Homologous recombination_Homo sapiens_hsa034402.66441200
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60254952
8Fanconi anemia pathway_Homo sapiens_hsa034602.54480305
9RNA degradation_Homo sapiens_hsa030182.50028026
10Spliceosome_Homo sapiens_hsa030402.29694202
11Nucleotide excision repair_Homo sapiens_hsa034202.27426899
12Basal transcription factors_Homo sapiens_hsa030222.22520030
13Phototransduction_Homo sapiens_hsa047442.09716533
14Non-homologous end-joining_Homo sapiens_hsa034502.08868504
15mRNA surveillance pathway_Homo sapiens_hsa030151.99992110
16One carbon pool by folate_Homo sapiens_hsa006701.94045277
17RNA polymerase_Homo sapiens_hsa030201.92333043
18Olfactory transduction_Homo sapiens_hsa047401.91759260
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86122238
20p53 signaling pathway_Homo sapiens_hsa041151.83177734
21Herpes simplex infection_Homo sapiens_hsa051681.54413450
22Pyrimidine metabolism_Homo sapiens_hsa002401.47139431
23Nicotine addiction_Homo sapiens_hsa050331.43175335
24MicroRNAs in cancer_Homo sapiens_hsa052061.42407452
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42034937
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37905380
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36239658
28Gap junction_Homo sapiens_hsa045401.36217749
29Taste transduction_Homo sapiens_hsa047421.33823705
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28294604
31HTLV-I infection_Homo sapiens_hsa051661.27205656
32Colorectal cancer_Homo sapiens_hsa052101.25884233
33Pancreatic cancer_Homo sapiens_hsa052121.25505483
34Notch signaling pathway_Homo sapiens_hsa043301.24854031
35Chronic myeloid leukemia_Homo sapiens_hsa052201.23652847
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21320066
37Regulation of autophagy_Homo sapiens_hsa041401.20291005
38Oocyte meiosis_Homo sapiens_hsa041141.18413991
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17888800
40Inositol phosphate metabolism_Homo sapiens_hsa005621.16725470
41Oxytocin signaling pathway_Homo sapiens_hsa049211.16590500
42Morphine addiction_Homo sapiens_hsa050321.16084399
43Thyroid cancer_Homo sapiens_hsa052161.15422505
44Small cell lung cancer_Homo sapiens_hsa052221.14598178
45Circadian entrainment_Homo sapiens_hsa047131.13754703
46Viral carcinogenesis_Homo sapiens_hsa052031.10139734
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09915622
48Epstein-Barr virus infection_Homo sapiens_hsa051691.07200130
49Long-term potentiation_Homo sapiens_hsa047201.06266832
50TGF-beta signaling pathway_Homo sapiens_hsa043501.06247420
51Primary immunodeficiency_Homo sapiens_hsa053401.03655999
52ABC transporters_Homo sapiens_hsa020101.01561348
53Calcium signaling pathway_Homo sapiens_hsa040201.00838228
54Allograft rejection_Homo sapiens_hsa053301.00148323
55Hepatitis B_Homo sapiens_hsa051610.98603160
56Lysine degradation_Homo sapiens_hsa003100.98076101
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97829847
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97436678
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95456332
60Non-small cell lung cancer_Homo sapiens_hsa052230.95374485
61GABAergic synapse_Homo sapiens_hsa047270.93298836
62Endometrial cancer_Homo sapiens_hsa052130.92821636
63Measles_Homo sapiens_hsa051620.91251075
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.88866740
65Butanoate metabolism_Homo sapiens_hsa006500.88602822
66MAPK signaling pathway_Homo sapiens_hsa040100.87603112
67Adherens junction_Homo sapiens_hsa045200.86188821
68Basal cell carcinoma_Homo sapiens_hsa052170.85942713
69Amphetamine addiction_Homo sapiens_hsa050310.85533222
70Purine metabolism_Homo sapiens_hsa002300.84873634
71Cocaine addiction_Homo sapiens_hsa050300.84385614
72Graft-versus-host disease_Homo sapiens_hsa053320.82507256
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81207591
74cAMP signaling pathway_Homo sapiens_hsa040240.81047426
75Prolactin signaling pathway_Homo sapiens_hsa049170.80970563
76Cholinergic synapse_Homo sapiens_hsa047250.79717340
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77002769
78Hippo signaling pathway_Homo sapiens_hsa043900.76642384
79Long-term depression_Homo sapiens_hsa047300.76533146
80Glutamatergic synapse_Homo sapiens_hsa047240.75209762
81Salivary secretion_Homo sapiens_hsa049700.75049045
82Acute myeloid leukemia_Homo sapiens_hsa052210.74972987
83Viral myocarditis_Homo sapiens_hsa054160.74860778
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74155953
85Prostate cancer_Homo sapiens_hsa052150.74065209
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73798273
87Type I diabetes mellitus_Homo sapiens_hsa049400.73160269
88Influenza A_Homo sapiens_hsa051640.72690271
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.72542152
90Antigen processing and presentation_Homo sapiens_hsa046120.72443037
91Apoptosis_Homo sapiens_hsa042100.70039374
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.69759021
93B cell receptor signaling pathway_Homo sapiens_hsa046620.69581902
94Systemic lupus erythematosus_Homo sapiens_hsa053220.68238077
95Insulin secretion_Homo sapiens_hsa049110.67216071
96Pathways in cancer_Homo sapiens_hsa052000.66850858
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66841716
98Vitamin B6 metabolism_Homo sapiens_hsa007500.66103302
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.64905314
100Bladder cancer_Homo sapiens_hsa052190.64640839
101FoxO signaling pathway_Homo sapiens_hsa040680.64186203
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64050404
103Type II diabetes mellitus_Homo sapiens_hsa049300.63585147
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63579243
105Estrogen signaling pathway_Homo sapiens_hsa049150.63257010
106mTOR signaling pathway_Homo sapiens_hsa041500.62952807
107ErbB signaling pathway_Homo sapiens_hsa040120.62009962
108Autoimmune thyroid disease_Homo sapiens_hsa053200.61099357
109Ovarian steroidogenesis_Homo sapiens_hsa049130.60723368
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59433539
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59258228
112Asthma_Homo sapiens_hsa053100.58644489
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.57468768
114Hematopoietic cell lineage_Homo sapiens_hsa046400.56501501
115Dopaminergic synapse_Homo sapiens_hsa047280.56285034
116Toxoplasmosis_Homo sapiens_hsa051450.55117095
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54940693
118TNF signaling pathway_Homo sapiens_hsa046680.53806503
119Hedgehog signaling pathway_Homo sapiens_hsa043400.52963980
120Shigellosis_Homo sapiens_hsa051310.52019612
121Wnt signaling pathway_Homo sapiens_hsa043100.51598017
122Serotonergic synapse_Homo sapiens_hsa047260.51172459
123Circadian rhythm_Homo sapiens_hsa047100.51162999
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51062497
125Renin secretion_Homo sapiens_hsa049240.50992734
126Nitrogen metabolism_Homo sapiens_hsa009100.50945756
127Ribosome_Homo sapiens_hsa030100.49976604
128Leishmaniasis_Homo sapiens_hsa051400.48711777
129Gastric acid secretion_Homo sapiens_hsa049710.48389784
130T cell receptor signaling pathway_Homo sapiens_hsa046600.48366342
131Dorso-ventral axis formation_Homo sapiens_hsa043200.47305052
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45408545
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43914669
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43440745
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.43139022
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41686382
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41151559
138Melanoma_Homo sapiens_hsa052180.40206174
139Proteoglycans in cancer_Homo sapiens_hsa052050.39508546
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.38802050
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35913838
142Hepatitis C_Homo sapiens_hsa051600.34480826
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34217604
144Platelet activation_Homo sapiens_hsa046110.34099347
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33442322
146Glioma_Homo sapiens_hsa052140.33144704
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33058189
148VEGF signaling pathway_Homo sapiens_hsa043700.32278849
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32226662
150Alcoholism_Homo sapiens_hsa050340.32104310
151Choline metabolism in cancer_Homo sapiens_hsa052310.31194822
152Selenocompound metabolism_Homo sapiens_hsa004500.29921357

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