EIF4E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.55500997
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.53458082
3DNA deamination (GO:0045006)5.90803610
4chaperone-mediated protein transport (GO:0072321)5.77953284
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.60030725
6ATP synthesis coupled proton transport (GO:0015986)5.60030725
7establishment of integrated proviral latency (GO:0075713)5.41830548
8transcription from mitochondrial promoter (GO:0006390)5.34500966
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)5.20466482
10replication fork processing (GO:0031297)5.00040171
11formation of translation preinitiation complex (GO:0001731)4.99331590
12embryonic process involved in female pregnancy (GO:0060136)4.91789052
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.90536257
14negative regulation of ligase activity (GO:0051352)4.84401906
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.84401906
16respiratory electron transport chain (GO:0022904)4.81334373
17proline metabolic process (GO:0006560)4.80786428
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.71603337
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.70985530
20electron transport chain (GO:0022900)4.69980321
21establishment of viral latency (GO:0019043)4.64404259
22regulation of cellular amino acid metabolic process (GO:0006521)4.51798528
23protein neddylation (GO:0045116)4.49327585
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.49015658
25telomere maintenance via semi-conservative replication (GO:0032201)4.47941363
26anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.40756367
27somatic hypermutation of immunoglobulin genes (GO:0016446)4.36211338
28somatic diversification of immune receptors via somatic mutation (GO:0002566)4.36211338
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.29754192
30rRNA modification (GO:0000154)4.24708998
31positive regulation of protein homooligomerization (GO:0032464)4.21916875
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.17471021
33intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.17471021
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.17169978
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.17169978
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.17169978
37DNA strand elongation involved in DNA replication (GO:0006271)4.12114466
38viral mRNA export from host cell nucleus (GO:0046784)4.02945447
39signal transduction involved in DNA integrity checkpoint (GO:0072401)4.01951203
40signal transduction involved in DNA damage checkpoint (GO:0072422)4.01951203
41cotranslational protein targeting to membrane (GO:0006613)4.01391376
42protein targeting to ER (GO:0045047)4.00985571
43regulation of integrin activation (GO:0033623)3.97959928
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.96502305
45mitotic G1 DNA damage checkpoint (GO:0031571)3.96480102
46establishment of apical/basal cell polarity (GO:0035089)3.95547005
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.93246505
48DNA strand elongation (GO:0022616)3.90164755
49protein deneddylation (GO:0000338)3.89241148
50positive regulation of ligase activity (GO:0051351)3.87973135
51protein complex biogenesis (GO:0070271)3.86323285
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.84229130
53mitochondrial DNA metabolic process (GO:0032042)3.83046943
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.82851174
55telomere maintenance via recombination (GO:0000722)3.81386798
56translation (GO:0006412)3.81012908
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.79476827
58protein localization to endoplasmic reticulum (GO:0070972)3.76111957
59mitochondrial respiratory chain complex assembly (GO:0033108)3.76034188
60protein targeting to mitochondrion (GO:0006626)3.68870031
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.68084876
62regulation of mitochondrial translation (GO:0070129)3.66901482
63viral transcription (GO:0019083)3.66308824
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.66147756
65termination of RNA polymerase III transcription (GO:0006386)3.66147756
66DNA damage response, detection of DNA damage (GO:0042769)3.65672012
67DNA strand renaturation (GO:0000733)3.64985411
68regulation of ubiquitin-protein transferase activity (GO:0051438)3.61245662
69rRNA methylation (GO:0031167)3.60868083
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.60691397
71antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.59989344
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.58957130
73NADH dehydrogenase complex assembly (GO:0010257)3.58957130
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58957130
75regulation of ligase activity (GO:0051340)3.58256200
76base-excision repair (GO:0006284)3.55636422
77mitotic G1/S transition checkpoint (GO:0044819)3.55388097
78translational termination (GO:0006415)3.54267466
79establishment of protein localization to mitochondrial membrane (GO:0090151)3.52919436
80kinetochore assembly (GO:0051382)3.51627825
81maturation of 5.8S rRNA (GO:0000460)3.51034774
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.50157521
83G1 DNA damage checkpoint (GO:0044783)3.49033586
84regulation of translational fidelity (GO:0006450)3.48967987
85oxidative phosphorylation (GO:0006119)3.48660785
86protein localization to mitochondrion (GO:0070585)3.47842023
87establishment of protein localization to mitochondrion (GO:0072655)3.47206497
88inner mitochondrial membrane organization (GO:0007007)3.45086639
89oxidative demethylation (GO:0070989)3.41686505
90mitotic recombination (GO:0006312)3.38955057
91telomere maintenance via telomere lengthening (GO:0010833)3.38252091
92ribosome biogenesis (GO:0042254)3.37455205
93regulation of gene silencing by RNA (GO:0060966)3.37186845
94regulation of posttranscriptional gene silencing (GO:0060147)3.37186845
95regulation of gene silencing by miRNA (GO:0060964)3.37186845
96mRNA cleavage (GO:0006379)3.36399469
97* translational initiation (GO:0006413)3.35802706
98termination of RNA polymerase II transcription (GO:0006369)3.34877279
99negative regulation of protein ubiquitination (GO:0031397)3.34462915
1007-methylguanosine mRNA capping (GO:0006370)3.34152310
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33859923
102ribosomal large subunit biogenesis (GO:0042273)3.33173759
103establishment of monopolar cell polarity (GO:0061162)3.30206137
104establishment or maintenance of monopolar cell polarity (GO:0061339)3.30206137
105DNA integration (GO:0015074)3.29501220
106respiratory chain complex IV assembly (GO:0008535)3.27320388
107translational elongation (GO:0006414)3.26658874
108DNA double-strand break processing (GO:0000729)3.26042198
109meiotic chromosome segregation (GO:0045132)3.25523516
110sequestering of actin monomers (GO:0042989)3.25320549
111non-recombinational repair (GO:0000726)3.24305282
112double-strand break repair via nonhomologous end joining (GO:0006303)3.24305282
113regulation of protein homooligomerization (GO:0032462)3.24207068
114regulation of cellular amine metabolic process (GO:0033238)3.24192757
115ribonucleoprotein complex biogenesis (GO:0022613)3.23630466
1167-methylguanosine RNA capping (GO:0009452)3.22683791
117RNA capping (GO:0036260)3.22683791
118maturation of SSU-rRNA (GO:0030490)3.22318995
119cytochrome complex assembly (GO:0017004)3.21189519
120kinetochore organization (GO:0051383)3.20230984
121ribosome assembly (GO:0042255)3.19991843
122ATP biosynthetic process (GO:0006754)3.19901512
123CTP biosynthetic process (GO:0006241)3.19714881
124CTP metabolic process (GO:0046036)3.19714881
125rRNA processing (GO:0006364)3.18235671
126pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.17929558
127purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17902822
128purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17839850
129negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.17356292
130positive regulation of mitotic sister chromatid separation (GO:1901970)3.16417015
131positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.16417015
132positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.16417015
133positive regulation of cell cycle arrest (GO:0071158)3.14768990
134mitotic sister chromatid segregation (GO:0000070)3.12145583
135ribonucleoside triphosphate biosynthetic process (GO:0009201)3.11889991
136mitotic nuclear envelope disassembly (GO:0007077)3.11829762
137GTP biosynthetic process (GO:0006183)3.11573638
138DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.11435570
139cellular component biogenesis (GO:0044085)3.09507532
140ribosomal small subunit biogenesis (GO:0042274)3.09164456
141spliceosomal tri-snRNP complex assembly (GO:0000244)3.08777422
142DNA replication initiation (GO:0006270)3.08013162
143spliceosomal snRNP assembly (GO:0000387)3.07638964
144positive regulation of chromosome segregation (GO:0051984)3.07494871
145rRNA metabolic process (GO:0016072)3.07382840
146mitochondrial RNA metabolic process (GO:0000959)3.06367064
147proteasome assembly (GO:0043248)3.06267845
148cullin deneddylation (GO:0010388)3.06186782
149nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06129071
150hydrogen ion transmembrane transport (GO:1902600)3.05866914
151pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.04733502
152regulation of double-strand break repair (GO:2000779)3.03673891
153poly(A)+ mRNA export from nucleus (GO:0016973)3.02352894
154pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98867566
155negative regulation of cell cycle arrest (GO:0071157)2.98680022
156cellular protein complex disassembly (GO:0043624)2.98466465
157IMP biosynthetic process (GO:0006188)2.97386122
158negative regulation of mRNA processing (GO:0050686)2.97344929
159pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.94976780
160ribosomal small subunit assembly (GO:0000028)2.94765949
161negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94116959
162base-excision repair, AP site formation (GO:0006285)2.92245746
163pseudouridine synthesis (GO:0001522)2.91716846
164DNA ligation (GO:0006266)2.91051007
165nuclear envelope reassembly (GO:0031468)2.90521295
166mitotic nuclear envelope reassembly (GO:0007084)2.90521295
167negative regulation of JAK-STAT cascade (GO:0046426)2.90327149
168positive regulation of protein oligomerization (GO:0032461)2.87923127
169nuclear envelope disassembly (GO:0051081)2.84883047
170membrane disassembly (GO:0030397)2.84883047
171DNA topological change (GO:0006265)2.81383545
172positive regulation of developmental pigmentation (GO:0048087)2.81207054
173DNA replication checkpoint (GO:0000076)2.81097805
174apoptotic process involved in morphogenesis (GO:0060561)2.80788579
175negative regulation of RNA splicing (GO:0033119)2.80359992
176regulation of sister chromatid cohesion (GO:0007063)2.79890966
177regulation of RNA export from nucleus (GO:0046831)2.78042451
178trophectodermal cell differentiation (GO:0001829)2.77453513
179SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76088423
180single strand break repair (GO:0000012)2.75608469
181nodal signaling pathway (GO:0038092)2.75134166
182viral life cycle (GO:0019058)2.74914736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.47374848
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.73628363
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.02298003
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26824009
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06483426
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.92191917
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86467684
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.79830654
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76019241
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61868581
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.60638494
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46769623
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43624415
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.41614200
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.41614200
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.41614200
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36461190
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.34838517
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.34564960
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28706680
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.11884173
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.09349777
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09134800
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01406464
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00704414
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.99800735
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96969557
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96579977
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93209304
30XRN2_22483619_ChIP-Seq_HELA_Human1.92839543
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92727807
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87310097
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86525234
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.84526033
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83306283
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83077874
37DCP1A_22483619_ChIP-Seq_HELA_Human1.81522466
38* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77720633
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.75372283
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73791422
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73673970
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73618315
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.70807942
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69681195
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68354777
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68258421
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66249139
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66016649
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65222975
50GABP_19822575_ChIP-Seq_HepG2_Human1.64268561
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.63828692
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62837334
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62583826
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61601805
55VDR_23849224_ChIP-Seq_CD4+_Human1.60900810
56VDR_21846776_ChIP-Seq_THP-1_Human1.60652957
57TTF2_22483619_ChIP-Seq_HELA_Human1.55193178
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47535845
59* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47276148
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45189871
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45140969
62MYC_18940864_ChIP-ChIP_HL60_Human1.44415991
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43634847
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.42257156
65MYC_22102868_ChIP-Seq_BL_Human1.40462818
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36591986
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36562019
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36223216
69KDM5A_27292631_Chip-Seq_BREAST_Human1.34468260
70* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33470074
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33095285
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.32648137
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32070508
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.31800429
75FOXP3_21729870_ChIP-Seq_TREG_Human1.29467235
76* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28930658
77* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28387674
78* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27678755
79* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27133159
80NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26898145
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23320715
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23190521
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23111624
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20747340
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19606534
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17573700
87OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17187236
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.16487960
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16072400
90TFEB_21752829_ChIP-Seq_HELA_Human1.13312773
91POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12891699
92TP63_17297297_ChIP-ChIP_HaCaT_Human1.09740873
93NANOG_16153702_ChIP-ChIP_HESCs_Human1.09282818
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.08129792
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07229748
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06947322
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06736004
98* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06577232
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05777953
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05172915
101* SOX17_20123909_ChIP-Seq_XEN_Mouse1.04075492
102ZNF263_19887448_ChIP-Seq_K562_Human1.03893440
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03017225
104ELK1_19687146_ChIP-ChIP_HELA_Human1.02774717
105SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01740966
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99956830
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.99949563
108NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99827288
109* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99767305
110* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98402202
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97803416
112NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97796874
113IRF1_19129219_ChIP-ChIP_H3396_Human0.97619781
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97351622
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97000284
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.94971211
117AR_21909140_ChIP-Seq_LNCAP_Human0.93158085
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92469775
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92278073
120* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92124956
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.91364255
122ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90626187
123NANOG_18692474_ChIP-Seq_MESCs_Mouse0.90594004
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90022573
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89941151
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89499927
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.89428066
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81792914
129IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81623873
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79524860
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73772788
132VDR_22108803_ChIP-Seq_LS180_Human0.72723191
133* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69105328
134PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.68563416
135EOMES_21245162_ChIP-Seq_HESCs_Human0.67434758
136ELF5_23300383_ChIP-Seq_T47D_Human0.65162964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.38831813
2MP0010030_abnormal_orbit_morphology3.50076015
3MP0010094_abnormal_chromosome_stability3.37027555
4MP0004957_abnormal_blastocyst_morpholog3.26709956
5MP0003693_abnormal_embryo_hatching3.17180426
6MP0006292_abnormal_olfactory_placode3.07550597
7MP0003111_abnormal_nucleus_morphology3.00530522
8MP0003011_delayed_dark_adaptation2.71042274
9MP0003077_abnormal_cell_cycle2.65795096
10MP0009278_abnormal_bone_marrow2.61052183
11MP0008058_abnormal_DNA_repair2.60080721
12MP0000749_muscle_degeneration2.59665658
13MP0009379_abnormal_foot_pigmentation2.54778664
14MP0006072_abnormal_retinal_apoptosis2.51041859
15MP0010352_gastrointestinal_tract_polyps2.50337574
16MP0006036_abnormal_mitochondrial_physio2.48829263
17MP0000372_irregular_coat_pigmentation2.38390746
18MP0008932_abnormal_embryonic_tissue2.30114897
19MP0005171_absent_coat_pigmentation2.29038680
20MP0009697_abnormal_copulation2.25671913
21MP0005084_abnormal_gallbladder_morpholo2.17347982
22MP0002938_white_spotting2.10947416
23MP0003786_premature_aging2.08957398
24MP0006035_abnormal_mitochondrial_morpho1.90162023
25MP0004233_abnormal_muscle_weight1.84668996
26MP0000350_abnormal_cell_proliferation1.79217731
27MP0005076_abnormal_cell_differentiation1.77442753
28MP0004133_heterotaxia1.75372544
29MP0001730_embryonic_growth_arrest1.72126304
30MP0005397_hematopoietic_system_phenotyp1.69929735
31MP0001545_abnormal_hematopoietic_system1.69929735
32MP0000490_abnormal_crypts_of1.69147155
33MP0008789_abnormal_olfactory_epithelium1.64931418
34MP0008260_abnormal_autophagy1.64225424
35MP0001697_abnormal_embryo_size1.63105227
36MP0004197_abnormal_fetal_growth/weight/1.62944379
37MP0008007_abnormal_cellular_replicative1.59000074
38MP0001293_anophthalmia1.58311676
39MP0002086_abnormal_extraembryonic_tissu1.58224891
40MP0003567_abnormal_fetal_cardiomyocyte1.57796666
41MP0002653_abnormal_ependyma_morphology1.56719297
42MP0000750_abnormal_muscle_regeneration1.55819335
43MP0003890_abnormal_embryonic-extraembry1.54192170
44MP0006054_spinal_hemorrhage1.52490568
45MP0002085_abnormal_embryonic_tissue1.51639443
46MP0001672_abnormal_embryogenesis/_devel1.51137776
47MP0005380_embryogenesis_phenotype1.51137776
48MP0003195_calcinosis1.48009895
49MP0002277_abnormal_respiratory_mucosa1.47691348
50MP0002084_abnormal_developmental_patter1.47617465
51MP0003806_abnormal_nucleotide_metabolis1.47111067
52MP0005257_abnormal_intraocular_pressure1.45370407
53MP0002837_dystrophic_cardiac_calcinosis1.42622278
54MP0002249_abnormal_larynx_morphology1.41661132
55MP0002009_preneoplasia1.38995957
56MP0001853_heart_inflammation1.37489426
57MP0005671_abnormal_response_to1.36786129
58MP0002282_abnormal_trachea_morphology1.36093820
59MP0005253_abnormal_eye_physiology1.34034018
60MP0000358_abnormal_cell_content/1.32946566
61MP0003119_abnormal_digestive_system1.32271581
62MP0003453_abnormal_keratinocyte_physiol1.30277978
63MP0002139_abnormal_hepatobiliary_system1.28816815
64MP0002736_abnormal_nociception_after1.28626864
65MP0003984_embryonic_growth_retardation1.28538466
66MP0010307_abnormal_tumor_latency1.26531219
67MP0002080_prenatal_lethality1.26491428
68MP0009333_abnormal_splenocyte_physiolog1.26238257
69MP0008877_abnormal_DNA_methylation1.25782851
70MP0002396_abnormal_hematopoietic_system1.25223907
71MP0002088_abnormal_embryonic_growth/wei1.24331478
72MP0009384_cardiac_valve_regurgitation1.24267829
73MP0002019_abnormal_tumor_incidence1.24064581
74MP0003718_maternal_effect1.23628446
75MP0008995_early_reproductive_senescence1.22849730
76MP0009785_altered_susceptibility_to1.21218107
77MP0003941_abnormal_skin_development1.18612027
78MP0003705_abnormal_hypodermis_morpholog1.18300293
79MP0002148_abnormal_hypersensitivity_rea1.17716503
80MP0001529_abnormal_vocalization1.16038174
81MP0005023_abnormal_wound_healing1.13882076
82MP0002111_abnormal_tail_morphology1.13684452
83MP0000313_abnormal_cell_death1.11901722
84MP0009053_abnormal_anal_canal1.11287970
85MP0002254_reproductive_system_inflammat1.09660230
86MP0005499_abnormal_olfactory_system1.09513032
87MP0005394_taste/olfaction_phenotype1.09513032
88MP0002090_abnormal_vision1.08786613
89MP0003566_abnormal_cell_adhesion1.08579133
90MP0004142_abnormal_muscle_tone1.06604278
91MP0005174_abnormal_tail_pigmentation1.03765710
92MP0003828_pulmonary_edema1.03673250
93MP0003283_abnormal_digestive_organ0.99453660
94MP0005408_hypopigmentation0.98521750
95MP0005365_abnormal_bile_salt0.97918760
96MP0000685_abnormal_immune_system0.96237224
97MP0002102_abnormal_ear_morphology0.94506263
98MP0002405_respiratory_system_inflammati0.93058827
99MP0001145_abnormal_male_reproductive0.92542651
100MP0000470_abnormal_stomach_morphology0.91409694
101MP0005360_urolithiasis0.91052006
102MP0005391_vision/eye_phenotype0.90710313
103MP0001346_abnormal_lacrimal_gland0.89969026
104MP0000762_abnormal_tongue_morphology0.89965223
105MP0005085_abnormal_gallbladder_physiolo0.89501008
106MP0000371_diluted_coat_color0.88859528
107MP0002233_abnormal_nose_morphology0.88705257
108MP0002210_abnormal_sex_determination0.87613313
109MP0000049_abnormal_middle_ear0.87120376
110MP0002269_muscular_atrophy0.87118665
111MP0003221_abnormal_cardiomyocyte_apopto0.85352683
112MP0005508_abnormal_skeleton_morphology0.85042620
113MP0006082_CNS_inflammation0.84628664
114MP0001764_abnormal_homeostasis0.84422158
115MP0003755_abnormal_palate_morphology0.84065078
116MP0002932_abnormal_joint_morphology0.83130251
117MP0005501_abnormal_skin_physiology0.83072709
118MP0005330_cardiomyopathy0.82479996
119MP0004145_abnormal_muscle_electrophysio0.81897131
120MP0002163_abnormal_gland_morphology0.81250240
121MP0005387_immune_system_phenotype0.80600202
122MP0001790_abnormal_immune_system0.80600202
123MP0005410_abnormal_fertilization0.80428377
124MP0002295_abnormal_pulmonary_circulatio0.79942072
125MP0001286_abnormal_eye_development0.79785348
126MP0000432_abnormal_head_morphology0.79400058
127MP0003186_abnormal_redox_activity0.78939845
128MP0002060_abnormal_skin_morphology0.78311911
129MP0002114_abnormal_axial_skeleton0.77379834
130MP0001905_abnormal_dopamine_level0.76209695
131MP0002796_impaired_skin_barrier0.76110434
132MP0002132_abnormal_respiratory_system0.75480476
133MP0005083_abnormal_biliary_tract0.75471910
134MP0005075_abnormal_melanosome_morpholog0.73789658
135MP0001849_ear_inflammation0.73382479
136MP0002751_abnormal_autonomic_nervous0.72988578
137MP0003315_abnormal_perineum_morphology0.72908444
138MP0000689_abnormal_spleen_morphology0.72634201
139MP0009250_abnormal_appendicular_skeleto0.71858559
140MP0000751_myopathy0.70813535
141MP0002075_abnormal_coat/hair_pigmentati0.70791577
142MP0002697_abnormal_eye_size0.70670375
143MP0000747_muscle_weakness0.70399797
144MP0000703_abnormal_thymus_morphology0.70234297
145MP0005319_abnormal_enzyme/_coenzyme0.69970275
146MP0008438_abnormal_cutaneous_collagen0.67833738
147MP0002138_abnormal_hepatobiliary_system0.67741489
148MP0001727_abnormal_embryo_implantation0.67547949
149MP0001929_abnormal_gametogenesis0.67526713
150MP0001915_intracranial_hemorrhage0.67227692
151MP0003448_altered_tumor_morphology0.66558836
152MP0003936_abnormal_reproductive_system0.66548004
153MP0000653_abnormal_sex_gland0.66181903
154MP0005266_abnormal_metabolism0.65974219
155MP0000477_abnormal_intestine_morphology0.65618402
156MP0003385_abnormal_body_wall0.65614480
157MP0003935_abnormal_craniofacial_develop0.65291754
158MP0001666_abnormal_nutrient_absorption0.65191816
159MP0000015_abnormal_ear_pigmentation0.64725105
160MP0003136_yellow_coat_color0.64288036
161MP0002116_abnormal_craniofacial_bone0.64240426
162MP0000343_altered_response_to0.64221250
163MP0002722_abnormal_immune_system0.64077042
164MP0003122_maternal_imprinting0.63958269
165MP0001542_abnormal_bone_strength0.62307862
166MP0001186_pigmentation_phenotype0.61679809
167MP0002398_abnormal_bone_marrow0.61510807

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.02033790
2Abnormal mitochondria in muscle tissue (HP:0008316)5.47809389
3Acute encephalopathy (HP:0006846)5.39322503
4Mitochondrial inheritance (HP:0001427)5.04982590
5Progressive macrocephaly (HP:0004481)4.70070691
6Hepatocellular necrosis (HP:0001404)4.65402292
7Increased CSF lactate (HP:0002490)4.63030560
8Rib fusion (HP:0000902)4.51877440
9Hepatic necrosis (HP:0002605)4.29721028
10Concave nail (HP:0001598)4.17756126
11Rectovaginal fistula (HP:0000143)4.07364618
12Rectal fistula (HP:0100590)4.07364618
13Cerebral edema (HP:0002181)4.04875006
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.89102224
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.89102224
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.89053142
17Lipid accumulation in hepatocytes (HP:0006561)3.86532148
18Increased hepatocellular lipid droplets (HP:0006565)3.84715621
19Pustule (HP:0200039)3.80538151
20Abnormal hemoglobin (HP:0011902)3.77168982
21Aplasia/hypoplasia of the humerus (HP:0006507)3.62911660
22Absent radius (HP:0003974)3.62907334
23Increased IgM level (HP:0003496)3.54486762
24Facial hemangioma (HP:0000329)3.51984000
25Intestinal fistula (HP:0100819)3.51228863
26Absent thumb (HP:0009777)3.50127017
273-Methylglutaconic aciduria (HP:0003535)3.50025214
28Patellar aplasia (HP:0006443)3.46534967
29Colon cancer (HP:0003003)3.44914190
30Selective tooth agenesis (HP:0001592)3.44085767
31Vaginal fistula (HP:0004320)3.43368266
32Poikiloderma (HP:0001029)3.42154771
33Aplasia involving forearm bones (HP:0009822)3.38931027
34Absent forearm bone (HP:0003953)3.38931027
35Alopecia of scalp (HP:0002293)3.38751782
36Short humerus (HP:0005792)3.37464773
37Aplastic anemia (HP:0001915)3.25598756
38Lactic acidosis (HP:0003128)3.25421552
39Aplasia/Hypoplasia of the patella (HP:0006498)3.23606553
40Increased serum pyruvate (HP:0003542)3.20774365
41Tongue fasciculations (HP:0001308)3.18640589
42Respiratory failure (HP:0002878)3.17811957
43Ulnar bowing (HP:0003031)3.13077828
44Renal Fanconi syndrome (HP:0001994)3.10890506
45Oral leukoplakia (HP:0002745)3.09744874
46Breast hypoplasia (HP:0003187)3.01683759
47Muscle fibrillation (HP:0010546)2.99562649
48Exercise intolerance (HP:0003546)2.96034336
49Premature graying of hair (HP:0002216)2.93674418
50Increased serum lactate (HP:0002151)2.90761843
51Abnormality of cells of the erythroid lineage (HP:0012130)2.88483493
52Squamous cell carcinoma (HP:0002860)2.86427773
53Leukodystrophy (HP:0002415)2.86289569
54Generalized aminoaciduria (HP:0002909)2.84728432
55Reticulocytopenia (HP:0001896)2.81839487
56Birth length less than 3rd percentile (HP:0003561)2.79375253
57Increased intramyocellular lipid droplets (HP:0012240)2.77567421
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77090819
59Nemaline bodies (HP:0003798)2.76699122
60Optic disc pallor (HP:0000543)2.75396077
61Cellular immunodeficiency (HP:0005374)2.74723056
62Basal cell carcinoma (HP:0002671)2.74620267
63Coronal craniosynostosis (HP:0004440)2.73476032
64Abnormality of glycolysis (HP:0004366)2.73433474
65Dyschromatopsia (HP:0007641)2.73432451
66Lethargy (HP:0001254)2.71377939
67Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.68580501
68Vertebral hypoplasia (HP:0008417)2.68580501
69Aplasia of the musculature (HP:0100854)2.67230447
70Turricephaly (HP:0000262)2.63867169
71Exercise-induced muscle cramps (HP:0003710)2.61767249
72Hypoplasia of the radius (HP:0002984)2.55077381
73Orthostatic hypotension (HP:0001278)2.54315746
74Hyperglycinemia (HP:0002154)2.54252520
75Annular pancreas (HP:0001734)2.53698618
76Type I transferrin isoform profile (HP:0003642)2.52721538
77Respiratory difficulties (HP:0002880)2.52596923
78Trismus (HP:0000211)2.52429255
79Microvesicular hepatic steatosis (HP:0001414)2.52117506
80Muscle fiber inclusion bodies (HP:0100299)2.50111172
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.49328762
82Abnormality of the ileum (HP:0001549)2.48552320
83Muscle fiber atrophy (HP:0100295)2.48448476
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.45676347
85Redundant skin (HP:0001582)2.42878472
86Congenital hip dislocation (HP:0001374)2.42855286
87Hypochromic microcytic anemia (HP:0004840)2.41522153
88Abnormal number of erythroid precursors (HP:0012131)2.40590287
89Increased muscle lipid content (HP:0009058)2.40404047
90Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39576545
91Intestinal atresia (HP:0011100)2.39425597
92Amniotic constriction ring (HP:0009775)2.38088701
93Abnormality of placental membranes (HP:0011409)2.38088701
94Abnormality of serum amino acid levels (HP:0003112)2.36045757
95Abnormality of the labia minora (HP:0012880)2.34437200
96X-linked dominant inheritance (HP:0001423)2.33221001
97Degeneration of anterior horn cells (HP:0002398)2.26136694
98Abnormality of the anterior horn cell (HP:0006802)2.26136694
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25973578
100Abnormal number of incisors (HP:0011064)2.24453007
101Reduced antithrombin III activity (HP:0001976)2.23457257
102Methylmalonic acidemia (HP:0002912)2.22380554
103Vertebral fusion (HP:0002948)2.21842211
104CNS demyelination (HP:0007305)2.21829564
105Abnormality of male internal genitalia (HP:0000022)2.21400638
106Type 2 muscle fiber atrophy (HP:0003554)2.20760507
107Male infertility (HP:0003251)2.20157403
108Premature skin wrinkling (HP:0100678)2.19065900
109Cerebral hypomyelination (HP:0006808)2.16682199
110Pancytopenia (HP:0001876)2.14434525
111Methylmalonic aciduria (HP:0012120)2.13985346
112Bifid uvula (HP:0000193)2.13443853
113Popliteal pterygium (HP:0009756)2.12809811
114Rough bone trabeculation (HP:0100670)2.11886521
115Rhabdomyolysis (HP:0003201)2.10243334
116Calcaneovalgus deformity (HP:0001848)2.09382864
117Ependymoma (HP:0002888)2.09240457
118Delayed CNS myelination (HP:0002188)2.09022525
119Deformed tarsal bones (HP:0008119)2.08655662
120Hypochromic anemia (HP:0001931)2.08173655
121Broad alveolar ridges (HP:0000187)2.05604675
122Premature ovarian failure (HP:0008209)2.05421864
123Exertional dyspnea (HP:0002875)2.02478692
124Short chin (HP:0000331)2.00668830
125Carpal bone hypoplasia (HP:0001498)2.00201553
126Spinal muscular atrophy (HP:0007269)1.99235053
127Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95904589
128Abnormality of the astrocytes (HP:0100707)1.93264961
129Astrocytoma (HP:0009592)1.93264961
130Abnormality of alanine metabolism (HP:0010916)1.92624459
131Hyperalaninemia (HP:0003348)1.92624459
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92624459
133Abnormal trabecular bone morphology (HP:0100671)1.92209429
134Vitreoretinal degeneration (HP:0000655)1.89854421
135Capillary hemangiomas (HP:0005306)1.89465362
136Multiple enchondromatosis (HP:0005701)1.89228275
137Short thumb (HP:0009778)1.89195884
138Nausea (HP:0002018)1.88372842
139Distal arthrogryposis (HP:0005684)1.88350813
140Septo-optic dysplasia (HP:0100842)1.87861102
141Albinism (HP:0001022)1.87113469
142Emotional lability (HP:0000712)1.86946514
143Dicarboxylic aciduria (HP:0003215)1.86818619
144Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86818619
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86209136
146Carpal synostosis (HP:0009702)1.84952094
147Abdominal situs inversus (HP:0003363)1.84398005
148Abnormality of abdominal situs (HP:0011620)1.84398005
149Diaphragmatic weakness (HP:0009113)1.83814976
150Abnormality of serine family amino acid metabolism (HP:0010894)1.83803395
151Abnormality of glycine metabolism (HP:0010895)1.83803395
152Abnormality of urine glucose concentration (HP:0011016)1.83719182
153Glycosuria (HP:0003076)1.83719182
154Joint stiffness (HP:0001387)1.83307932
155Pallor (HP:0000980)1.82899746
156Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81321378
157Abnormal protein N-linked glycosylation (HP:0012347)1.81321378
158Abnormal protein glycosylation (HP:0012346)1.81321378
159Abnormal glycosylation (HP:0012345)1.81321378
160Macrocytic anemia (HP:0001972)1.81192457
161Hypotrichosis (HP:0001006)1.79365945
162Absent septum pellucidum (HP:0001331)1.78840328
163Abnormality of the septum pellucidum (HP:0007375)1.78707587
164Supernumerary spleens (HP:0009799)1.77449276
165Alacrima (HP:0000522)1.77442254
166Rhabdomyosarcoma (HP:0002859)1.76958034
167Hyperglycinuria (HP:0003108)1.76498182
168Dysautonomia (HP:0002459)1.76251365
169Stenosis of the external auditory canal (HP:0000402)1.75781669
170Hypotelorism (HP:0000601)1.75097632
171Secondary amenorrhea (HP:0000869)1.74008244
172Increased number of teeth (HP:0011069)1.73609626
173Chronic mucocutaneous candidiasis (HP:0002728)1.73308604
174Recurrent cutaneous fungal infections (HP:0011370)1.73308604
175Meckel diverticulum (HP:0002245)1.72919964
176Abnormality of methionine metabolism (HP:0010901)1.72590480
177Generalized amyotrophy (HP:0003700)1.72468352
178Agnosia (HP:0010524)1.72423519
179IgA deficiency (HP:0002720)1.71097701
180Choanal stenosis (HP:0000452)1.68367462
181Breech presentation (HP:0001623)1.68190400
182Acute lymphatic leukemia (HP:0006721)1.67171463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.48891985
2ICK4.42163610
3STK164.40535128
4DDR23.90863999
5MAP3K113.21747689
6TXK3.17789241
7MAP3K122.89563816
8BUB12.84631333
9PIM22.82750519
10MAP3K62.75812096
11MAPK152.57521626
12EIF2AK12.57295898
13WEE12.30037812
14CDK72.27373161
15TAF12.24927397
16PINK12.17193047
17MATK1.99480116
18BMX1.98490856
19FGR1.94971523
20NUAK11.84974830
21PLK31.81642531
22NME21.80319353
23TYRO31.78689670
24TESK21.75089330
25RPS6KB21.73893401
26TRIM281.67657976
27CDC71.65049341
28TLK11.60200806
29PIM11.57117916
30EPHA21.56996138
31DYRK31.56472232
32PLK11.53974332
33CSK1.53500190
34YES11.50418758
35DYRK1B1.50308230
36OBSCN1.49313957
37ZAK1.49289687
38LATS21.49138738
39BCKDK1.43407701
40CDK121.43050466
41CHEK21.40071629
42ACVR1B1.37479515
43CDK191.36543616
44TSSK61.36185989
45PDGFRA1.29991615
46DAPK11.29922487
47NEK21.28975701
48CSNK1G31.26116527
49PDK21.26020046
50PRKD21.20265889
51ATR1.18024354
52TRPM71.16997242
53UHMK11.14987373
54CDK61.14959700
55EIF2AK31.13596439
56AKT31.12098559
57BCR1.10633659
58CSNK1G11.09940774
59CSNK1A1L1.08380837
60SRPK11.06781755
61TTK0.99699432
62TESK10.94989838
63RPS6KL10.93895576
64RPS6KC10.93895576
65NEK10.93747382
66AURKB0.93170577
67EPHB20.92769697
68CSNK1G20.91322028
69AURKA0.89172461
70MYLK0.89121371
71CCNB10.88043934
72STK100.87002351
73TAOK20.85969951
74MAP2K70.85491633
75MAP3K100.83754371
76RPS6KA60.82448895
77PBK0.81468600
78ERBB30.80563628
79WNK30.79536955
80MAPK110.79353665
81PAK40.78375041
82CHEK10.76866715
83PLK40.75929715
84BRSK20.72803541
85MAPKAPK30.72444357
86CSNK2A10.71094499
87MAP3K80.70621994
88STK30.69426202
89GRK70.68941672
90STK38L0.67881449
91MTOR0.67635683
92CDC42BPA0.67594697
93CDK20.67572627
94DYRK20.65634626
95TIE10.65413736
96CDK40.64944229
97PAK10.63107064
98RPS6KA10.61829680
99GSK3A0.60299625
100CSNK2A20.59919130
101RPS6KA40.59626905
102STK40.59607679
103ALK0.57391734
104ATM0.57200862
105BRSK10.56752822
106VRK10.55988724
107PASK0.55287825
108MOS0.54031388
109CDK80.53071919
110MKNK10.51200950
111ARAF0.49649693
112IKBKB0.49594677
113ABL20.49088716
114LRRK20.48751105
115DAPK30.48267873
116GRK10.48045312
117TNIK0.46030263
118FES0.44092927
119OXSR10.43694148
120ILK0.43608844
121MKNK20.43274225
122KDR0.41260165
123MAPKAPK20.39991138
124PLK20.39033087
125PAK20.39029663
126ADRBK20.38974982
127CDK140.38782759
128CDK10.36852734
129EPHB10.36007734
130MELK0.35678734
131LIMK10.35409746
132LATS10.35169601
133LYN0.34652566
134EGFR0.34201502
135PRKCI0.34079964
136CDK180.32506373
137MAPK10.31797399
138PRKG20.31598060
139CDK30.31404523
140NME10.31335482
141MAP4K10.31117702
142MAP4K20.29523086
143CDK11A0.29440074
144CSNK1A10.28701851
145PRKCG0.28620183
146CDK150.28493834
147RPS6KA50.28185562
148EIF2AK20.28035509
149MST40.27942083
150STK240.27701761
151PDK30.27590448
152BMPR1B0.26948281
153TYK20.25935882
154MAPKAPK50.23846532
155PHKG20.21900519

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.66283201
2DNA replication_Homo sapiens_hsa030304.47998075
3Oxidative phosphorylation_Homo sapiens_hsa001904.05221428
4Base excision repair_Homo sapiens_hsa034103.72727106
5Ribosome_Homo sapiens_hsa030103.64004615
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45781626
7Proteasome_Homo sapiens_hsa030503.07272017
8Protein export_Homo sapiens_hsa030602.99940200
9Spliceosome_Homo sapiens_hsa030402.97318858
10Nucleotide excision repair_Homo sapiens_hsa034202.72847183
11Homologous recombination_Homo sapiens_hsa034402.69943551
12* RNA transport_Homo sapiens_hsa030132.64685750
13RNA polymerase_Homo sapiens_hsa030202.52223226
14Alzheimers disease_Homo sapiens_hsa050102.31687714
15Fatty acid biosynthesis_Homo sapiens_hsa000612.13907214
16Fanconi anemia pathway_Homo sapiens_hsa034602.09789452
17Cell cycle_Homo sapiens_hsa041102.07951262
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05534010
19One carbon pool by folate_Homo sapiens_hsa006702.02963099
20p53 signaling pathway_Homo sapiens_hsa041151.86450650
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85782070
22mRNA surveillance pathway_Homo sapiens_hsa030151.75472954
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73446012
24Pyrimidine metabolism_Homo sapiens_hsa002401.68930535
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67885762
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64411690
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60858240
28Cardiac muscle contraction_Homo sapiens_hsa042601.58106377
29Propanoate metabolism_Homo sapiens_hsa006401.44783859
30Sulfur relay system_Homo sapiens_hsa041221.36531171
31Basal transcription factors_Homo sapiens_hsa030221.31659396
32Pyruvate metabolism_Homo sapiens_hsa006201.28472841
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27013197
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26860155
35Biosynthesis of amino acids_Homo sapiens_hsa012301.26362236
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26265317
37Fatty acid elongation_Homo sapiens_hsa000621.21999363
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15130834
39RNA degradation_Homo sapiens_hsa030181.14324573
40Hippo signaling pathway_Homo sapiens_hsa043901.13954387
41Folate biosynthesis_Homo sapiens_hsa007901.13020811
42Non-homologous end-joining_Homo sapiens_hsa034501.09387852
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08656026
44Notch signaling pathway_Homo sapiens_hsa043301.08597120
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07016584
46Epstein-Barr virus infection_Homo sapiens_hsa051691.06688340
47Hedgehog signaling pathway_Homo sapiens_hsa043401.03814445
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02447873
49Arginine and proline metabolism_Homo sapiens_hsa003300.98041702
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97818359
51TGF-beta signaling pathway_Homo sapiens_hsa043500.96700254
52Sulfur metabolism_Homo sapiens_hsa009200.94271373
53Shigellosis_Homo sapiens_hsa051310.91935114
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91687293
55Butanoate metabolism_Homo sapiens_hsa006500.91299442
56Legionellosis_Homo sapiens_hsa051340.89868651
57Adherens junction_Homo sapiens_hsa045200.88552496
58Herpes simplex infection_Homo sapiens_hsa051680.87448040
59Glutathione metabolism_Homo sapiens_hsa004800.86424022
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86152337
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84785955
62Bladder cancer_Homo sapiens_hsa052190.84363556
63Peroxisome_Homo sapiens_hsa041460.84154913
64Fructose and mannose metabolism_Homo sapiens_hsa000510.83889224
65Basal cell carcinoma_Homo sapiens_hsa052170.80838643
66Primary immunodeficiency_Homo sapiens_hsa053400.79852213
67Metabolic pathways_Homo sapiens_hsa011000.77972021
68Viral carcinogenesis_Homo sapiens_hsa052030.77163149
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76557858
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.73594244
71MicroRNAs in cancer_Homo sapiens_hsa052060.71316594
72Fatty acid degradation_Homo sapiens_hsa000710.68591951
73Collecting duct acid secretion_Homo sapiens_hsa049660.68266020
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64218776
75Regulation of autophagy_Homo sapiens_hsa041400.62575657
76HTLV-I infection_Homo sapiens_hsa051660.61661593
77Small cell lung cancer_Homo sapiens_hsa052220.61090341
78Oocyte meiosis_Homo sapiens_hsa041140.61079146
79Purine metabolism_Homo sapiens_hsa002300.59860112
80Viral myocarditis_Homo sapiens_hsa054160.56585829
81Tryptophan metabolism_Homo sapiens_hsa003800.55649444
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.54617967
83Systemic lupus erythematosus_Homo sapiens_hsa053220.54087800
84Vibrio cholerae infection_Homo sapiens_hsa051100.53257801
85Selenocompound metabolism_Homo sapiens_hsa004500.52362369
86Measles_Homo sapiens_hsa051620.51398218
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50549393
88Huntingtons disease_Homo sapiens_hsa050160.50424181
89Wnt signaling pathway_Homo sapiens_hsa043100.48661169
90Apoptosis_Homo sapiens_hsa042100.48098123
91* mTOR signaling pathway_Homo sapiens_hsa041500.47013685
92Pentose phosphate pathway_Homo sapiens_hsa000300.45383206
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45372099
94Fatty acid metabolism_Homo sapiens_hsa012120.44498740
95Antigen processing and presentation_Homo sapiens_hsa046120.44251665
96Chemical carcinogenesis_Homo sapiens_hsa052040.44048132
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41334132
98Acute myeloid leukemia_Homo sapiens_hsa052210.40238636
99Colorectal cancer_Homo sapiens_hsa052100.39765963
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.38632539
101Chronic myeloid leukemia_Homo sapiens_hsa052200.38264163
102Vitamin digestion and absorption_Homo sapiens_hsa049770.38146256
103Galactose metabolism_Homo sapiens_hsa000520.37716134
104beta-Alanine metabolism_Homo sapiens_hsa004100.36937071
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36886884
106Tight junction_Homo sapiens_hsa045300.35615127
107Phenylalanine metabolism_Homo sapiens_hsa003600.34988102
108Lysine degradation_Homo sapiens_hsa003100.34898606
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34641654
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34591470
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34541692
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34098901
113Hepatitis B_Homo sapiens_hsa051610.34017204
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32213788
115Steroid biosynthesis_Homo sapiens_hsa001000.31519786
116Graft-versus-host disease_Homo sapiens_hsa053320.31480368
117Rheumatoid arthritis_Homo sapiens_hsa053230.31012339
118Parkinsons disease_Homo sapiens_hsa050120.28967863
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28875933
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28590788
121Thyroid cancer_Homo sapiens_hsa052160.27995092
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.27933124
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27808923
124VEGF signaling pathway_Homo sapiens_hsa043700.27719876
125Pathways in cancer_Homo sapiens_hsa052000.26862058
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26785542
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.26702412
128Retinol metabolism_Homo sapiens_hsa008300.26639742
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.26018631
130Carbon metabolism_Homo sapiens_hsa012000.25958636
131Proteoglycans in cancer_Homo sapiens_hsa052050.25109678
132Arachidonic acid metabolism_Homo sapiens_hsa005900.24922041
133Caffeine metabolism_Homo sapiens_hsa002320.24406399
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22584574
135Tyrosine metabolism_Homo sapiens_hsa003500.22567932
136Circadian rhythm_Homo sapiens_hsa047100.21915456
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21441222
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21170189
139* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18703757
140N-Glycan biosynthesis_Homo sapiens_hsa005100.17545604
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.17392216
142Allograft rejection_Homo sapiens_hsa053300.16963062
143Prostate cancer_Homo sapiens_hsa052150.16257614
144Intestinal immune network for IgA production_Homo sapiens_hsa046720.16109756
145Phototransduction_Homo sapiens_hsa047440.12298514
146Vitamin B6 metabolism_Homo sapiens_hsa007500.11839921
147Starch and sucrose metabolism_Homo sapiens_hsa005000.09517210

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