EIF4E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.17335100
2purine nucleobase biosynthetic process (GO:0009113)4.97406755
3mitotic metaphase plate congression (GO:0007080)4.80128066
4nucleobase biosynthetic process (GO:0046112)4.70062905
5proteasome assembly (GO:0043248)4.51673538
6DNA replication initiation (GO:0006270)4.41434597
7DNA replication checkpoint (GO:0000076)4.41142434
8ribosome assembly (GO:0042255)4.34840553
9negative regulation of DNA-dependent DNA replication (GO:2000104)4.30900919
10ribosome biogenesis (GO:0042254)4.26757962
11viral mRNA export from host cell nucleus (GO:0046784)4.24747278
12CENP-A containing nucleosome assembly (GO:0034080)4.21952170
13DNA deamination (GO:0045006)4.19694973
14telomere maintenance via semi-conservative replication (GO:0032201)4.19594687
15DNA strand elongation involved in DNA replication (GO:0006271)4.06597775
16chromatin remodeling at centromere (GO:0031055)4.04906817
17metaphase plate congression (GO:0051310)4.01419000
18regulation of mitotic spindle checkpoint (GO:1903504)4.00813676
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.00813676
20maturation of 5.8S rRNA (GO:0000460)3.98230535
21DNA strand elongation (GO:0022616)3.89734753
22spliceosomal snRNP assembly (GO:0000387)3.84413216
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.83936161
24termination of RNA polymerase III transcription (GO:0006386)3.83936161
25telomere maintenance via recombination (GO:0000722)3.83838923
26replication fork processing (GO:0031297)3.83444229
27rRNA modification (GO:0000154)3.79261701
28attachment of spindle microtubules to kinetochore (GO:0008608)3.78682830
297-methylguanosine mRNA capping (GO:0006370)3.77838300
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76055769
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.73826571
327-methylguanosine RNA capping (GO:0009452)3.73538499
33RNA capping (GO:0036260)3.73538499
34kinetochore assembly (GO:0051382)3.71005246
35kinetochore organization (GO:0051383)3.66512582
36regulation of spindle organization (GO:0090224)3.66313330
37DNA replication-independent nucleosome assembly (GO:0006336)3.64558530
38DNA replication-independent nucleosome organization (GO:0034724)3.64558530
39pseudouridine synthesis (GO:0001522)3.62293712
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62283043
41formation of translation preinitiation complex (GO:0001731)3.59965388
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.57546266
43mitotic recombination (GO:0006312)3.56658552
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56328217
45polyamine biosynthetic process (GO:0006596)3.52652641
46ribonucleoprotein complex biogenesis (GO:0022613)3.52225652
47regulation of centriole replication (GO:0046599)3.49520483
48histone exchange (GO:0043486)3.48253611
49cullin deneddylation (GO:0010388)3.47148730
50protein deneddylation (GO:0000338)3.43094881
51maturation of SSU-rRNA (GO:0030490)3.41190054
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.40463685
53protein localization to kinetochore (GO:0034501)3.40440067
54termination of RNA polymerase I transcription (GO:0006363)3.40338514
55DNA catabolic process, exonucleolytic (GO:0000738)3.39603004
56rRNA processing (GO:0006364)3.39514935
57telomere maintenance via telomere lengthening (GO:0010833)3.38192423
58establishment of chromosome localization (GO:0051303)3.37715991
59protein K6-linked ubiquitination (GO:0085020)3.36851266
60respiratory chain complex IV assembly (GO:0008535)3.34907987
61* G1/S transition of mitotic cell cycle (GO:0000082)3.34027998
62* cell cycle G1/S phase transition (GO:0044843)3.34027998
63transcription elongation from RNA polymerase I promoter (GO:0006362)3.32768689
64transcription-coupled nucleotide-excision repair (GO:0006283)3.32677251
65spindle checkpoint (GO:0031577)3.30834471
66RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.30795893
67rRNA metabolic process (GO:0016072)3.28368035
68protein neddylation (GO:0045116)3.27843607
69IMP biosynthetic process (GO:0006188)3.27129331
70rRNA methylation (GO:0031167)3.26740361
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25837770
72synapsis (GO:0007129)3.24926243
73mitotic sister chromatid segregation (GO:0000070)3.23308955
74negative regulation of DNA recombination (GO:0045910)3.22442108
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21805743
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.21805743
77ribosomal large subunit biogenesis (GO:0042273)3.21115764
78somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.21019093
79isotype switching (GO:0045190)3.21019093
80somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.21019093
81protein localization to chromosome, centromeric region (GO:0071459)3.20585124
82transcription from RNA polymerase I promoter (GO:0006360)3.19882795
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19310166
84negative regulation of ligase activity (GO:0051352)3.18667426
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18667426
86negative regulation of mitotic sister chromatid separation (GO:2000816)3.18627948
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18627948
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18627948
89negative regulation of sister chromatid segregation (GO:0033046)3.18627948
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16243624
91regulation of DNA endoreduplication (GO:0032875)3.15917977
92mitotic spindle checkpoint (GO:0071174)3.15152624
93mitotic spindle assembly checkpoint (GO:0007094)3.15084477
94negative regulation of chromosome segregation (GO:0051985)3.14853246
95spindle assembly checkpoint (GO:0071173)3.14735345
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14173052
97mitotic nuclear envelope disassembly (GO:0007077)3.10713210
98DNA replication-dependent nucleosome assembly (GO:0006335)3.10617878
99DNA replication-dependent nucleosome organization (GO:0034723)3.10617878
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09114878
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08362869
102nucleotide-excision repair, DNA gap filling (GO:0006297)3.08176858
103DNA ligation (GO:0006266)3.07550826
104regulation of helicase activity (GO:0051095)3.07243919
105recombinational repair (GO:0000725)3.03626209
106water-soluble vitamin biosynthetic process (GO:0042364)3.02936566
107response to X-ray (GO:0010165)3.02340724
108transcription elongation from RNA polymerase II promoter (GO:0006368)3.02261193
109DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02200164
110double-strand break repair via homologous recombination (GO:0000724)3.01699872
111positive regulation of ligase activity (GO:0051351)3.01187601
112GMP metabolic process (GO:0046037)3.00690271
113regulation of chromosome segregation (GO:0051983)2.99942847
114regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99550251
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99516611
116cellular component biogenesis (GO:0044085)2.99393418
117signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98884264
118signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98884264
119signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98884264
120DNA-dependent DNA replication (GO:0006261)2.97806076
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97515791
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97515791
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.94145281
124establishment of protein localization to mitochondrial membrane (GO:0090151)2.93717856
125regulation of cellular amino acid metabolic process (GO:0006521)2.93129080
126L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92811864
127regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92632826
128DNA-templated transcription, elongation (GO:0006354)2.92335648
129regulation of sister chromatid segregation (GO:0033045)2.91906430
130regulation of mitotic sister chromatid segregation (GO:0033047)2.91906430
131histone mRNA metabolic process (GO:0008334)2.91186593
132non-recombinational repair (GO:0000726)2.89323443
133double-strand break repair via nonhomologous end joining (GO:0006303)2.89323443
134establishment of integrated proviral latency (GO:0075713)2.89135187
135telomere maintenance via telomerase (GO:0007004)2.88630981
136regulation of mitotic sister chromatid separation (GO:0010965)2.87876694
137lactate metabolic process (GO:0006089)2.85101247
138signal peptide processing (GO:0006465)2.80285573
139cytochrome complex assembly (GO:0017004)2.78554359
140regulation of meiosis I (GO:0060631)2.78372220
141postreplication repair (GO:0006301)2.73445003
142DNA damage response, detection of DNA damage (GO:0042769)2.72424715
143peptidyl-histidine modification (GO:0018202)2.71243848
144mitotic sister chromatid cohesion (GO:0007064)2.71111705
145IMP metabolic process (GO:0046040)2.69275014
146histone H2A acetylation (GO:0043968)2.69087389
147resolution of meiotic recombination intermediates (GO:0000712)2.68067500
148mitochondrial RNA metabolic process (GO:0000959)2.62137242
149response to pheromone (GO:0019236)2.60493048
150centriole replication (GO:0007099)2.60288829
151somatic recombination of immunoglobulin gene segments (GO:0016447)2.59838701
152mitotic G2/M transition checkpoint (GO:0044818)2.59780530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.00802343
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.38096092
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25715262
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.85936076
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65932328
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.55074895
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51549638
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.31286686
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22924511
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.16448334
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.12875378
12SALL1_21062744_ChIP-ChIP_HESCs_Human3.11477833
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00123410
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98861282
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91630657
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.91342886
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89205127
18VDR_22108803_ChIP-Seq_LS180_Human2.79909492
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78185818
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74237645
21VDR_23849224_ChIP-Seq_CD4+_Human2.71421467
22ZNF274_21170338_ChIP-Seq_K562_Hela2.62016557
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59778920
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56718438
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56221134
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49130208
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47723002
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43552131
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39713480
30FUS_26573619_Chip-Seq_HEK293_Human2.35131823
31ELK1_19687146_ChIP-ChIP_HELA_Human2.30228738
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27907351
33* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23564435
34DCP1A_22483619_ChIP-Seq_HELA_Human2.18446988
35E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16788664
36FOXP3_21729870_ChIP-Seq_TREG_Human2.16483281
37GABP_19822575_ChIP-Seq_HepG2_Human2.15042082
38XRN2_22483619_ChIP-Seq_HELA_Human2.14692125
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14137628
40AR_21909140_ChIP-Seq_LNCAP_Human2.13463330
41ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12391636
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.12177279
43TAF15_26573619_Chip-Seq_HEK293_Human2.10214671
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08054912
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06378400
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03220575
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01518813
48IGF1R_20145208_ChIP-Seq_DFB_Human2.00658379
49YY1_21170310_ChIP-Seq_MESCs_Mouse2.00502010
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99795814
51P300_19829295_ChIP-Seq_ESCs_Human1.98933768
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.94911070
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94107475
54GBX2_23144817_ChIP-Seq_PC3_Human1.90204585
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87781425
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.83990407
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82405682
58TTF2_22483619_ChIP-Seq_HELA_Human1.81536853
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80722850
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73860060
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.72582466
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71739918
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65039144
64* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57471165
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56611416
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55030281
67* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52948685
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52945470
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50707616
70* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50212443
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46797950
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45212473
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41383754
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40820065
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39189999
76ER_23166858_ChIP-Seq_MCF-7_Human1.37273700
77CIITA_25753668_ChIP-Seq_RAJI_Human1.36468741
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.35634845
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.35173578
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34143214
81KDM5A_27292631_Chip-Seq_BREAST_Human1.32383370
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30143365
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29337196
84* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28114755
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25136485
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23912583
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22442510
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21390967
89* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20982683
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.20167585
91SMAD4_21799915_ChIP-Seq_A2780_Human1.19623441
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18453114
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17791757
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.17782677
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.17724633
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16488296
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.15637513
98BCAT_22108803_ChIP-Seq_LS180_Human1.15563791
99MYC_18940864_ChIP-ChIP_HL60_Human1.15456665
100* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15221045
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14021689
102SOX2_19829295_ChIP-Seq_ESCs_Human1.13966943
103NANOG_19829295_ChIP-Seq_ESCs_Human1.13966943
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13348783
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12642148
106CBP_20019798_ChIP-Seq_JUKART_Human1.12642148
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12204169
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12057292
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11194405
110TCF4_22108803_ChIP-Seq_LS180_Human1.08697685
111SOX2_16153702_ChIP-ChIP_HESCs_Human1.07775439
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06497918
113STAT3_23295773_ChIP-Seq_U87_Human1.06302285
114* NANOG_18555785_Chip-Seq_ESCs_Mouse1.05737824
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05072163
116AR_25329375_ChIP-Seq_VCAP_Human1.04960738
117* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04808649
118* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02963644
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.02807534
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02444844
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01035665
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01000386
123SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97651590
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97501961
125P53_22387025_ChIP-Seq_ESCs_Mouse0.96735193
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93652351
127* P300_18555785_Chip-Seq_ESCs_Mouse0.93064701
128TP53_22573176_ChIP-Seq_HFKS_Human0.92803224
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92603674
130FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92220322
131FOXA1_25329375_ChIP-Seq_VCAP_Human0.92191435
132FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92191435
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89643000
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88668562
135KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87180232
136* TFEB_21752829_ChIP-Seq_HELA_Human0.85879970
137IRF1_19129219_ChIP-ChIP_H3396_Human0.85764878
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84591043
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83925410
140FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83009591
141SPI1_23547873_ChIP-Seq_NB4_Human0.81025386
142CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79978521
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.78484533
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73493559
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72912362
146* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71532149
147NANOG_16153702_ChIP-ChIP_HESCs_Human0.70183862
148* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67109358
149NANOG_21062744_ChIP-ChIP_HESCs_Human0.66908910
150KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.66329681
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.65595006
152SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.65542172
153NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.64941493
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.64922947
155PCGF2_27294783_Chip-Seq_ESCs_Mouse0.64757834
156TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.62461078
157EWS_26573619_Chip-Seq_HEK293_Human0.61148938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.74687314
2MP0010094_abnormal_chromosome_stability4.50049064
3MP0003111_abnormal_nucleus_morphology4.08013879
4MP0008058_abnormal_DNA_repair4.00724940
5MP0004957_abnormal_blastocyst_morpholog3.74482017
6MP0008057_abnormal_DNA_replication3.61713446
7MP0003077_abnormal_cell_cycle3.59268559
8MP0008007_abnormal_cellular_replicative3.51945210
9MP0003123_paternal_imprinting3.04539549
10MP0008877_abnormal_DNA_methylation2.99250826
11MP0003136_yellow_coat_color2.57755464
12MP0003786_premature_aging2.52808918
13MP0003718_maternal_effect2.50973528
14MP0003890_abnormal_embryonic-extraembry2.44113233
15MP0008932_abnormal_embryonic_tissue2.40917509
16MP0000372_irregular_coat_pigmentation2.39917201
17MP0002396_abnormal_hematopoietic_system2.36419181
18MP0003195_calcinosis2.34103219
19MP0006292_abnormal_olfactory_placode2.25165779
20MP0008260_abnormal_autophagy2.11010473
21MP0006072_abnormal_retinal_apoptosis2.06514672
22MP0005451_abnormal_body_composition1.99694285
23MP0001188_hyperpigmentation1.92900983
24MP0005409_darkened_coat_color1.87543183
25MP0002736_abnormal_nociception_after1.82476696
26MP0000569_abnormal_digit_pigmentation1.77615479
27MP0000490_abnormal_crypts_of1.77004071
28MP0001986_abnormal_taste_sensitivity1.71987822
29MP0000015_abnormal_ear_pigmentation1.71664235
30MP0000350_abnormal_cell_proliferation1.63692093
31MP0003646_muscle_fatigue1.62122652
32MP0002210_abnormal_sex_determination1.57987278
33MP0002837_dystrophic_cardiac_calcinosis1.57428147
34MP0001293_anophthalmia1.57263275
35MP0002160_abnormal_reproductive_system1.51792801
36MP0005253_abnormal_eye_physiology1.50973357
37MP0002132_abnormal_respiratory_system1.50770543
38MP0009697_abnormal_copulation1.48346087
39MP0005551_abnormal_eye_electrophysiolog1.48237336
40MP0001485_abnormal_pinna_reflex1.45499554
41MP0001730_embryonic_growth_arrest1.44802359
42MP0006054_spinal_hemorrhage1.42338105
43MP0003315_abnormal_perineum_morphology1.40922075
44MP0003119_abnormal_digestive_system1.40888870
45MP0003787_abnormal_imprinting1.40168487
46MP0002102_abnormal_ear_morphology1.38921286
47MP0004133_heterotaxia1.38853174
48MP0006035_abnormal_mitochondrial_morpho1.36529466
49MP0003121_genomic_imprinting1.36443693
50MP0003880_abnormal_central_pattern1.36239128
51MP0009333_abnormal_splenocyte_physiolog1.35806424
52MP0005670_abnormal_white_adipose1.35757472
53MP0003567_abnormal_fetal_cardiomyocyte1.34800754
54MP0001968_abnormal_touch/_nociception1.31441288
55MP0000427_abnormal_hair_cycle1.31025122
56MP0000647_abnormal_sebaceous_gland1.30660556
57MP0005367_renal/urinary_system_phenotyp1.28332078
58MP0000516_abnormal_urinary_system1.28332078
59MP0009046_muscle_twitch1.27536905
60MP0001145_abnormal_male_reproductive1.25470714
61MP0002090_abnormal_vision1.25333358
62MP0001929_abnormal_gametogenesis1.23918586
63MP0001853_heart_inflammation1.23597034
64MP0001984_abnormal_olfaction1.20275325
65MP0002095_abnormal_skin_pigmentation1.19897507
66MP0006036_abnormal_mitochondrial_physio1.19665234
67MP0000653_abnormal_sex_gland1.16467431
68MP0001697_abnormal_embryo_size1.15274922
69MP0001542_abnormal_bone_strength1.13276816
70MP0001672_abnormal_embryogenesis/_devel1.12487276
71MP0005380_embryogenesis_phenotype1.12487276
72MP0003221_abnormal_cardiomyocyte_apopto1.11718185
73MP0000750_abnormal_muscle_regeneration1.11514431
74MP0002080_prenatal_lethality1.10358630
75MP0010307_abnormal_tumor_latency1.09327554
76MP0005075_abnormal_melanosome_morpholog1.08471026
77MP0003950_abnormal_plasma_membrane1.07616989
78MP0008872_abnormal_physiological_respon1.07178516
79MP0000313_abnormal_cell_death1.06048424
80MP0001119_abnormal_female_reproductive1.05913200
81MP0002938_white_spotting1.04921428
82MP0004808_abnormal_hematopoietic_stem1.03884792
83* MP0002019_abnormal_tumor_incidence1.01031711
84MP0005389_reproductive_system_phenotype1.00903378
85MP0003806_abnormal_nucleotide_metabolis0.98431848
86MP0003984_embryonic_growth_retardation0.98194759
87MP0008995_early_reproductive_senescence0.98113325
88MP0000631_abnormal_neuroendocrine_gland0.98104628
89MP0003122_maternal_imprinting0.97604285
90MP0005397_hematopoietic_system_phenotyp0.96141721
91MP0001545_abnormal_hematopoietic_system0.96141721
92MP0003137_abnormal_impulse_conducting0.95600190
93MP0005084_abnormal_gallbladder_morpholo0.94859162
94MP0001486_abnormal_startle_reflex0.94284145
95MP0002254_reproductive_system_inflammat0.94189566
96MP0002088_abnormal_embryonic_growth/wei0.92010230
97MP0009379_abnormal_foot_pigmentation0.89880707
98MP0009745_abnormal_behavioral_response0.87564258
99MP0008789_abnormal_olfactory_epithelium0.87436138
100MP0001286_abnormal_eye_development0.87270016
101MP0005645_abnormal_hypothalamus_physiol0.87224138
102MP0000383_abnormal_hair_follicle0.86563132
103MP0002163_abnormal_gland_morphology0.86156873
104MP0002085_abnormal_embryonic_tissue0.85376784
105MP0001529_abnormal_vocalization0.85035604
106MP0003938_abnormal_ear_development0.85015463
107MP0002233_abnormal_nose_morphology0.83634659
108MP0001177_atelectasis0.83425277
109MP0003186_abnormal_redox_activity0.83079215
110MP0010030_abnormal_orbit_morphology0.82467007
111MP0006276_abnormal_autonomic_nervous0.82363046
112MP0004043_abnormal_pH_regulation0.81748300
113MP0001186_pigmentation_phenotype0.81401226
114MP0002075_abnormal_coat/hair_pigmentati0.80640058
115MP0002234_abnormal_pharynx_morphology0.80531855
116MP0003828_pulmonary_edema0.80384834
117MP0000681_abnormal_thyroid_gland0.80189288
118MP0001324_abnormal_eye_pigmentation0.79983789
119MP0005174_abnormal_tail_pigmentation0.79951668
120MP0002272_abnormal_nervous_system0.79940269
121MP0010678_abnormal_skin_adnexa0.78915894
122MP0005391_vision/eye_phenotype0.78509832
123MP0005187_abnormal_penis_morphology0.77793868
124MP0000465_gastrointestinal_hemorrhage0.77719239
125MP0004147_increased_porphyrin_level0.77070347
126MP0005646_abnormal_pituitary_gland0.75927036
127MP0000049_abnormal_middle_ear0.75861532
128MP0009703_decreased_birth_body0.74536023
129MP0003698_abnormal_male_reproductive0.73340420
130MP0005379_endocrine/exocrine_gland_phen0.73157503
131MP0002751_abnormal_autonomic_nervous0.72299242
132MP0000358_abnormal_cell_content/0.71529961
133MP0005410_abnormal_fertilization0.71427051
134MP0001764_abnormal_homeostasis0.66403327
135MP0000566_synostosis0.65643011
136MP0000689_abnormal_spleen_morphology0.65476103
137MP0004215_abnormal_myocardial_fiber0.65169569
138MP0001919_abnormal_reproductive_system0.64622258
139MP0003699_abnormal_female_reproductive0.62857590
140MP0002722_abnormal_immune_system0.62520499
141MP0003937_abnormal_limbs/digits/tail_de0.62367024
142MP0003941_abnormal_skin_development0.61527798
143MP0009672_abnormal_birth_weight0.61237822
144MP0002398_abnormal_bone_marrow0.60944756
145MP0002127_abnormal_cardiovascular_syste0.58846383
146MP0002177_abnormal_outer_ear0.58693110
147MP0002086_abnormal_extraembryonic_tissu0.57528452
148MP0002161_abnormal_fertility/fecundity0.55282368
149MP0002084_abnormal_developmental_patter0.54568359
150MP0004197_abnormal_fetal_growth/weight/0.53957193
151MP0002638_abnormal_pupillary_reflex0.51155647
152MP0000703_abnormal_thymus_morphology0.49600708
153MP0005395_other_phenotype0.49032161

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.37479536
2Type I transferrin isoform profile (HP:0003642)3.79039690
3Breast hypoplasia (HP:0003187)3.66265742
4Type 2 muscle fiber atrophy (HP:0003554)3.46619300
5Reduced antithrombin III activity (HP:0001976)3.41285242
6Aplastic anemia (HP:0001915)3.26245629
7Patellar aplasia (HP:0006443)3.20867109
8Muscle fiber atrophy (HP:0100295)3.18696565
9Colon cancer (HP:0003003)3.16764995
10Irregular epiphyses (HP:0010582)3.13569348
11Oral leukoplakia (HP:0002745)3.08778808
12Pancreatic fibrosis (HP:0100732)3.08238831
13Aplasia/Hypoplasia of the patella (HP:0006498)3.06702021
14Cerebral hypomyelination (HP:0006808)3.05222205
15Rough bone trabeculation (HP:0100670)3.03215995
16Abnormality of the preputium (HP:0100587)2.98605689
17Abnormal spermatogenesis (HP:0008669)2.98447867
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94550295
19Chromsome breakage (HP:0040012)2.93635270
20Carpal bone hypoplasia (HP:0001498)2.93361738
21Meckel diverticulum (HP:0002245)2.91028694
22Methylmalonic acidemia (HP:0002912)2.79433500
23Abnormal number of erythroid precursors (HP:0012131)2.75740616
24Abnormality of cells of the erythroid lineage (HP:0012130)2.75645176
25Abnormality of the ileum (HP:0001549)2.72436860
26Abnormality of chromosome stability (HP:0003220)2.68865945
27Selective tooth agenesis (HP:0001592)2.68677973
28Degeneration of anterior horn cells (HP:0002398)2.68162277
29Abnormality of the anterior horn cell (HP:0006802)2.68162277
30True hermaphroditism (HP:0010459)2.59754361
31Intestinal atresia (HP:0011100)2.58818970
32Impulsivity (HP:0100710)2.58140027
33Sparse eyelashes (HP:0000653)2.58010732
34Abnormal protein glycosylation (HP:0012346)2.56315846
35Abnormal glycosylation (HP:0012345)2.56315846
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56315846
37Abnormal protein N-linked glycosylation (HP:0012347)2.56315846
38Pancreatic cysts (HP:0001737)2.53409490
39Microvesicular hepatic steatosis (HP:0001414)2.50819361
40Volvulus (HP:0002580)2.49576217
41Acute encephalopathy (HP:0006846)2.48101832
42Short middle phalanx of the 5th finger (HP:0004220)2.45441179
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.45410901
44Abnormality of midbrain morphology (HP:0002418)2.44350085
45Molar tooth sign on MRI (HP:0002419)2.44350085
46Bone marrow hypocellularity (HP:0005528)2.40089762
47Capillary hemangiomas (HP:0005306)2.40001158
48Hypoplasia of the fovea (HP:0007750)2.39432790
49Aplasia/Hypoplasia of the fovea (HP:0008060)2.39432790
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.36845363
51Progressive macrocephaly (HP:0004481)2.34981513
52Premature graying of hair (HP:0002216)2.34658987
53Abnormality of the columella (HP:0009929)2.34061098
54Methylmalonic aciduria (HP:0012120)2.32679421
55Ependymoma (HP:0002888)2.29432658
56Abnormality of the labia minora (HP:0012880)2.29096312
57Abnormal lung lobation (HP:0002101)2.28355544
58Hepatocellular necrosis (HP:0001404)2.27975830
59Abnormality of methionine metabolism (HP:0010901)2.27915822
60Duodenal stenosis (HP:0100867)2.27851227
61Small intestinal stenosis (HP:0012848)2.27851227
62Nephronophthisis (HP:0000090)2.22736555
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20450505
64Abnormal trabecular bone morphology (HP:0100671)2.20280056
65Alopecia of scalp (HP:0002293)2.18768638
66Myelodysplasia (HP:0002863)2.18666137
67Glioma (HP:0009733)2.18557607
68Absent epiphyses (HP:0010577)2.17982434
69Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.17982434
70Megaloblastic anemia (HP:0001889)2.16456860
71Shoulder girdle muscle weakness (HP:0003547)2.16117912
72Azoospermia (HP:0000027)2.14590368
73Medial flaring of the eyebrow (HP:0010747)2.14208275
74Clubbing of toes (HP:0100760)2.13188848
75Sloping forehead (HP:0000340)2.12794123
76Entropion (HP:0000621)2.11179403
77Abnormality of serum amino acid levels (HP:0003112)2.09657512
78Progressive inability to walk (HP:0002505)2.09371575
79Hypothermia (HP:0002045)2.08277856
80Embryonal renal neoplasm (HP:0011794)2.04233152
81Nephroblastoma (Wilms tumor) (HP:0002667)2.03686653
82Increased CSF lactate (HP:0002490)2.03569567
83Progressive muscle weakness (HP:0003323)2.03539025
84Increased serum lactate (HP:0002151)2.03277233
85Abnormality of the pons (HP:0007361)2.02481163
86Abnormal mitochondria in muscle tissue (HP:0008316)2.02193165
87Pelvic girdle muscle weakness (HP:0003749)2.00609847
88Hyperglycinemia (HP:0002154)2.00330854
89Reticulocytopenia (HP:0001896)2.00324926
90Supernumerary spleens (HP:0009799)2.00041522
91Abolished electroretinogram (ERG) (HP:0000550)1.99265227
92Rhabdomyosarcoma (HP:0002859)1.98907588
93Pulmonary fibrosis (HP:0002206)1.98834309
94Congenital, generalized hypertrichosis (HP:0004540)1.98318509
95Abnormality of alanine metabolism (HP:0010916)1.97885922
96Hyperalaninemia (HP:0003348)1.97885922
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97885922
98Neoplasm of the adrenal gland (HP:0100631)1.97409094
99Increased hepatocellular lipid droplets (HP:0006565)1.96912022
100Abnormality of vitamin B metabolism (HP:0004340)1.96769592
101Pancreatic islet-cell hyperplasia (HP:0004510)1.96538105
102Abnormality of the fovea (HP:0000493)1.95299343
103Pendular nystagmus (HP:0012043)1.94189175
104Hypoplasia of the pons (HP:0012110)1.93247541
105Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92885464
106Cleft eyelid (HP:0000625)1.92261900
107Acute necrotizing encephalopathy (HP:0006965)1.91483156
108Small hand (HP:0200055)1.91272772
109Ectopic kidney (HP:0000086)1.89542531
110Aplasia involving forearm bones (HP:0009822)1.88953263
111Absent forearm bone (HP:0003953)1.88953263
112Secondary amenorrhea (HP:0000869)1.88132863
113Hepatic necrosis (HP:0002605)1.87966642
114Flat capital femoral epiphysis (HP:0003370)1.87876095
115Gaze-evoked nystagmus (HP:0000640)1.87342444
116Genital tract atresia (HP:0001827)1.87084304
117Macrocytic anemia (HP:0001972)1.86387082
1183-Methylglutaconic aciduria (HP:0003535)1.86001311
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.85169927
120Follicular hyperkeratosis (HP:0007502)1.84931059
121Mitochondrial inheritance (HP:0001427)1.84881156
122Absent thumb (HP:0009777)1.84878777
123Abnormality of the renal medulla (HP:0100957)1.84784520
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84699916
125CNS hypomyelination (HP:0003429)1.84150760
126Breast aplasia (HP:0100783)1.83658332
127Abnormality of glycine metabolism (HP:0010895)1.83313080
128Abnormality of serine family amino acid metabolism (HP:0010894)1.83313080
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83308139
130Microretrognathia (HP:0000308)1.82611882
131Abnormality of the astrocytes (HP:0100707)1.82529849
132Astrocytoma (HP:0009592)1.82529849
133Abnormality of the umbilical cord (HP:0010881)1.82388404
134Medulloblastoma (HP:0002885)1.82336541
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.82236219
136Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.81976187
137Pancytopenia (HP:0001876)1.81852614
138Rimmed vacuoles (HP:0003805)1.81498454
139Lipid accumulation in hepatocytes (HP:0006561)1.80999453
140Abnormal hair whorl (HP:0010721)1.80499082
141Postnatal microcephaly (HP:0005484)1.80392024
142Sclerocornea (HP:0000647)1.79973407
143Abnormality of the duodenum (HP:0002246)1.79560616
144Preaxial hand polydactyly (HP:0001177)1.79507393
145Triphalangeal thumb (HP:0001199)1.79025082
146Abnormality of the vitamin B12 metabolism (HP:0004341)1.78764704
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78523443
148Absent radius (HP:0003974)1.78291011
149Dry hair (HP:0011359)1.78290481
150Dandy-Walker malformation (HP:0001305)1.77796470
151Vaginal atresia (HP:0000148)1.76602515
152Hyperglycinuria (HP:0003108)1.76406884
153Agnosia (HP:0010524)1.76287640
154Occipital encephalocele (HP:0002085)1.75722236
155Cerebral edema (HP:0002181)1.75266146
156Abnormality of the renal cortex (HP:0011035)1.73920277
157Oligodactyly (hands) (HP:0001180)1.72880778
158Abnormality of the carotid arteries (HP:0005344)1.72241629
159Congenital primary aphakia (HP:0007707)1.72108480
160Gastrointestinal atresia (HP:0002589)1.71779658
161Congenital stationary night blindness (HP:0007642)1.69169450
162Biliary tract neoplasm (HP:0100574)1.68663980
163Horseshoe kidney (HP:0000085)1.68454264
164Gait imbalance (HP:0002141)1.67354836
165Neoplasm of the adrenal cortex (HP:0100641)1.67225643
166Neoplasm of the colon (HP:0100273)1.67098983
167Bifid tongue (HP:0010297)1.67002801
168Inability to walk (HP:0002540)1.66567997
169Anencephaly (HP:0002323)1.65048839
170Septo-optic dysplasia (HP:0100842)1.64293744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.99849985
2BUB14.69615833
3WEE13.95373520
4EIF2AK33.77112047
5STK163.75853656
6FRK3.51260237
7EIF2AK13.39377781
8WNK32.99708329
9TRIM282.93035444
10BRSK22.71381449
11SRPK12.49619324
12ACVR1B2.47643404
13PLK42.46275810
14CDC72.43762329
15TSSK62.31053262
16CCNB12.30762057
17NUAK12.29286351
18NME21.91029641
19NEK11.79230452
20VRK11.77203530
21PLK31.76535252
22NEK21.75876198
23PLK11.70965637
24BRSK11.62275466
25TAF11.58537358
26MAP4K21.56126040
27EIF2AK21.50273188
28TTK1.47164468
29VRK21.43700807
30GRK11.42986103
31BCR1.39709587
32ZAK1.33627314
33AKT31.33084337
34MUSK1.31839579
35* MKNK11.30560681
36OXSR11.30135797
37PNCK1.29834834
38MAP2K71.28813458
39DYRK31.24716955
40STK391.24012475
41AURKB1.16144207
42MAP3K41.08611702
43ATR1.06339545
44CDK71.05979529
45CDK81.00880802
46CAMKK21.00652780
47AURKA0.99935520
48CHEK20.99261509
49PIM20.98986795
50BRAF0.98019882
51NLK0.95993024
52CSNK1G10.94703592
53CASK0.93619154
54INSRR0.90553646
55TLK10.86973028
56CSNK1G20.83686350
57CDK190.82275400
58RPS6KA40.79892484
59PLK20.78005687
60CHEK10.73316736
61CDK40.71638020
62MAP3K120.69598255
63TEC0.69358328
64PRKCE0.68379274
65CSNK2A10.68146764
66NME10.65985332
67BMPR1B0.64992557
68NEK60.64716904
69PINK10.63977551
70STK38L0.61778272
71BRD40.61401752
72PASK0.61362025
73PAK30.60905062
74FGFR20.60648661
75CSNK1A1L0.60217901
76PDK30.60047526
77PDK40.60047526
78ATM0.56762202
79SIK30.56584703
80WNK40.55934696
81* MKNK20.54898601
82CSNK2A20.54000139
83CLK10.53504444
84IRAK30.51651939
85CDK30.50792869
86STK30.50138887
87STK240.50051396
88ERBB40.49795436
89YES10.49096513
90FGFR10.48385722
91MINK10.47173197
92FER0.47022327
93* PRKCG0.46781532
94PAK10.46709713
95NEK90.44432360
96ALK0.44341939
97TAOK20.44073031
98CDK10.43415480
99CDK20.43145046
100ERBB30.41300720
101TESK20.40940262
102EPHA40.40287735
103MAP3K80.40270479
104TGFBR10.39557110
105MST40.38934960
106RPS6KB10.38728138
107PDK20.38326548
108KIT0.38322719
109PIM10.38295637
110DYRK20.37711329
111CSNK1E0.35705185
112MELK0.35253174
113MAP3K60.34134904
114RPS6KB20.33601456
115PRKCI0.33493739
116CAMK2A0.30847424
117TIE10.30713611
118FLT30.30601607
119ADRBK10.30449883
120DAPK10.29947328
121MAPK130.29741551
122STK40.29464571
123PIK3CA0.26643651
124STK100.26523075
125CSNK1D0.25944275
126PRKDC0.24939681
127PAK40.24152355
128CSNK1G30.23750604
129MAP3K50.22411111
130OBSCN0.21816223
131TXK0.21677764
132PBK0.20645244
133CSNK1A10.18995088
134PRKACB0.18570863
135ADRBK20.18438214
136MARK30.18187188
137ABL20.17924654
138SCYL20.16566270

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44342077
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.11668669
3RNA polymerase_Homo sapiens_hsa030204.07221834
4Proteasome_Homo sapiens_hsa030503.71393259
5Mismatch repair_Homo sapiens_hsa034303.57363692
6Homologous recombination_Homo sapiens_hsa034403.13950801
7Spliceosome_Homo sapiens_hsa030403.05620377
8* RNA transport_Homo sapiens_hsa030133.01329363
9Nucleotide excision repair_Homo sapiens_hsa034202.75161288
10Cell cycle_Homo sapiens_hsa041102.72607684
11Pyrimidine metabolism_Homo sapiens_hsa002402.72154210
12Basal transcription factors_Homo sapiens_hsa030222.62505315
13Ribosome_Homo sapiens_hsa030102.59390193
14Base excision repair_Homo sapiens_hsa034102.53546630
15Vitamin B6 metabolism_Homo sapiens_hsa007502.49179352
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37373059
17Propanoate metabolism_Homo sapiens_hsa006402.33394506
18Fanconi anemia pathway_Homo sapiens_hsa034602.30781958
19RNA degradation_Homo sapiens_hsa030182.03893215
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03830163
21Purine metabolism_Homo sapiens_hsa002301.82920835
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81866851
23p53 signaling pathway_Homo sapiens_hsa041151.79176138
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78583855
25Steroid biosynthesis_Homo sapiens_hsa001001.70494622
26One carbon pool by folate_Homo sapiens_hsa006701.61405011
27Non-homologous end-joining_Homo sapiens_hsa034501.60064432
28Protein export_Homo sapiens_hsa030601.57170160
29Butanoate metabolism_Homo sapiens_hsa006501.54592459
30Regulation of autophagy_Homo sapiens_hsa041401.40502635
31mRNA surveillance pathway_Homo sapiens_hsa030151.28506074
32Fatty acid elongation_Homo sapiens_hsa000621.24636352
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24414118
34Pyruvate metabolism_Homo sapiens_hsa006201.20534480
35Epstein-Barr virus infection_Homo sapiens_hsa051691.16843025
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14214554
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07980401
38Oocyte meiosis_Homo sapiens_hsa041141.06830774
39Folate biosynthesis_Homo sapiens_hsa007901.06690975
40Nitrogen metabolism_Homo sapiens_hsa009101.06473096
41Tryptophan metabolism_Homo sapiens_hsa003801.04494459
42Nicotine addiction_Homo sapiens_hsa050330.98093412
43Sulfur metabolism_Homo sapiens_hsa009200.96194332
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.93004032
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.90755562
46Herpes simplex infection_Homo sapiens_hsa051680.88830575
47Circadian rhythm_Homo sapiens_hsa047100.88478634
48Pentose phosphate pathway_Homo sapiens_hsa000300.87740223
49Huntingtons disease_Homo sapiens_hsa050160.87635336
50Peroxisome_Homo sapiens_hsa041460.85343185
51Caffeine metabolism_Homo sapiens_hsa002320.84505310
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84086172
53Oxidative phosphorylation_Homo sapiens_hsa001900.81937004
54N-Glycan biosynthesis_Homo sapiens_hsa005100.79692307
55beta-Alanine metabolism_Homo sapiens_hsa004100.78095039
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76826209
57Parkinsons disease_Homo sapiens_hsa050120.75373518
58Thyroid cancer_Homo sapiens_hsa052160.75143633
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74321722
60Ether lipid metabolism_Homo sapiens_hsa005650.73837518
61Biosynthesis of amino acids_Homo sapiens_hsa012300.71871490
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.69566853
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68855331
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68718784
65Fatty acid metabolism_Homo sapiens_hsa012120.66021318
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65219444
67Fatty acid degradation_Homo sapiens_hsa000710.64600015
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62820681
69Linoleic acid metabolism_Homo sapiens_hsa005910.61840029
70Systemic lupus erythematosus_Homo sapiens_hsa053220.59778183
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58881207
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58163881
73Taste transduction_Homo sapiens_hsa047420.57901833
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56982667
75Legionellosis_Homo sapiens_hsa051340.56341177
76Retinol metabolism_Homo sapiens_hsa008300.53470853
77Antigen processing and presentation_Homo sapiens_hsa046120.51399915
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49428375
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.48166866
80Olfactory transduction_Homo sapiens_hsa047400.48021054
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47497600
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46794393
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46088142
84Metabolic pathways_Homo sapiens_hsa011000.44635427
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44172986
86Viral carcinogenesis_Homo sapiens_hsa052030.43591778
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43304236
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42580946
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41596118
90Autoimmune thyroid disease_Homo sapiens_hsa053200.40889163
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.40200640
92Sulfur relay system_Homo sapiens_hsa041220.40103934
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39846278
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38639512
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38281373
96Chemical carcinogenesis_Homo sapiens_hsa052040.37953346
97Hedgehog signaling pathway_Homo sapiens_hsa043400.37225820
98Vitamin digestion and absorption_Homo sapiens_hsa049770.35974131
99Hippo signaling pathway_Homo sapiens_hsa043900.35874144
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33261771
101HTLV-I infection_Homo sapiens_hsa051660.33167993
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33139257
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.32635342
104Serotonergic synapse_Homo sapiens_hsa047260.32070204
105Fructose and mannose metabolism_Homo sapiens_hsa000510.31916140
106Arginine and proline metabolism_Homo sapiens_hsa003300.30769161
107Selenocompound metabolism_Homo sapiens_hsa004500.30603366
108Measles_Homo sapiens_hsa051620.29043882
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.28935884
110Arachidonic acid metabolism_Homo sapiens_hsa005900.28212059
111Fat digestion and absorption_Homo sapiens_hsa049750.27505766
112GABAergic synapse_Homo sapiens_hsa047270.27349208
113Glutathione metabolism_Homo sapiens_hsa004800.25930662
114Carbon metabolism_Homo sapiens_hsa012000.25697791
115Type I diabetes mellitus_Homo sapiens_hsa049400.25072391
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23735753
117Hepatitis B_Homo sapiens_hsa051610.21527716
118Phagosome_Homo sapiens_hsa041450.21355058
119Influenza A_Homo sapiens_hsa051640.21192609
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21115142
121Asthma_Homo sapiens_hsa053100.21039407
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20659560
123Hematopoietic cell lineage_Homo sapiens_hsa046400.20049564
124TGF-beta signaling pathway_Homo sapiens_hsa043500.19168950
125Galactose metabolism_Homo sapiens_hsa000520.18881675
126Alcoholism_Homo sapiens_hsa050340.18200604
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17817100
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17792074
129Small cell lung cancer_Homo sapiens_hsa052220.17167086
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17080323
131Allograft rejection_Homo sapiens_hsa053300.16640154
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16486155
133Alzheimers disease_Homo sapiens_hsa050100.15360640
134Collecting duct acid secretion_Homo sapiens_hsa049660.14924346
135Melanoma_Homo sapiens_hsa052180.14304608
136Rheumatoid arthritis_Homo sapiens_hsa053230.13390472
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.12788971
138Renin-angiotensin system_Homo sapiens_hsa046140.12575631
139Apoptosis_Homo sapiens_hsa042100.11964369
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10746613
141Colorectal cancer_Homo sapiens_hsa052100.09566886
142Phototransduction_Homo sapiens_hsa047440.09490586
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08503992

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