EIF4A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)7.89408476
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31193116
3neuron cell-cell adhesion (GO:0007158)5.18305012
4synaptic vesicle exocytosis (GO:0016079)5.12229595
5vocalization behavior (GO:0071625)5.03964547
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.82000011
7positive regulation of cellular amide metabolic process (GO:0034250)4.68083991
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65617744
9presynaptic membrane assembly (GO:0097105)4.56155369
10regulation of synaptic vesicle exocytosis (GO:2000300)4.48935576
11protein localization to synapse (GO:0035418)4.43320237
12regulation of glutamate receptor signaling pathway (GO:1900449)4.38596079
13synapsis (GO:0007129)4.35483387
14negative regulation of synaptic transmission, GABAergic (GO:0032229)4.32544659
15glutamate secretion (GO:0014047)4.32153824
16gamma-aminobutyric acid signaling pathway (GO:0007214)4.28533188
17neurotransmitter secretion (GO:0007269)4.20463407
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.14819718
19response to histamine (GO:0034776)4.14582136
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.12308362
21neuron-neuron synaptic transmission (GO:0007270)4.09695799
22presynaptic membrane organization (GO:0097090)4.09689427
23neuronal action potential propagation (GO:0019227)4.05480625
24protein K11-linked deubiquitination (GO:0035871)3.93638671
25positive regulation of p38MAPK cascade (GO:1900745)3.92776615
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.92236711
27positive regulation of meiotic cell cycle (GO:0051446)3.90540874
28hair cycle (GO:0042633)3.88658416
29molting cycle (GO:0042303)3.88658416
30energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.83341452
31ATP hydrolysis coupled proton transport (GO:0015991)3.83341452
32regulation of synaptic vesicle transport (GO:1902803)3.81984684
33pyrimidine dimer repair (GO:0006290)3.81813427
34long-term synaptic potentiation (GO:0060291)3.80198580
35regulation of glutamate secretion (GO:0014048)3.78413632
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.77962803
37glutamate receptor signaling pathway (GO:0007215)3.77612750
38postsynaptic membrane organization (GO:0001941)3.77552992
39locomotory exploration behavior (GO:0035641)3.70855499
40piRNA metabolic process (GO:0034587)3.68961826
41neurotransmitter-gated ion channel clustering (GO:0072578)3.68397802
42synaptic transmission, glutamatergic (GO:0035249)3.66172525
43neuron recognition (GO:0008038)3.65314901
44positive regulation of glomerulus development (GO:0090193)3.58723042
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55714850
46protein prenylation (GO:0018342)3.52544545
47prenylation (GO:0097354)3.52544545
48neurotransmitter transport (GO:0006836)3.51875522
49female mating behavior (GO:0060180)3.51257893
50transferrin transport (GO:0033572)3.51237367
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49908752
52regulation of protein kinase A signaling (GO:0010738)3.49858623
53positive regulation of synapse assembly (GO:0051965)3.47894976
54detection of calcium ion (GO:0005513)3.46937701
55exploration behavior (GO:0035640)3.45567713
56regulation of postsynaptic membrane potential (GO:0060078)3.45398524
57synaptic vesicle maturation (GO:0016188)3.44678977
58DNA methylation involved in gamete generation (GO:0043046)3.37718750
59righting reflex (GO:0060013)3.33015475
60behavioral response to cocaine (GO:0048148)3.31840031
61regulation of somitogenesis (GO:0014807)3.30369740
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.30177026
63establishment of skin barrier (GO:0061436)3.29965617
64transmission of nerve impulse (GO:0019226)3.29948675
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.28022639
66ferric iron transport (GO:0015682)3.27855744
67trivalent inorganic cation transport (GO:0072512)3.27855744
68regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26722469
69histone H3-K9 demethylation (GO:0033169)3.26551626
70regulation of neurotransmitter levels (GO:0001505)3.26266966
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26093159
72striatum development (GO:0021756)3.25548608
73startle response (GO:0001964)3.24909574
74dendritic spine morphogenesis (GO:0060997)3.24852470
75fear response (GO:0042596)3.22244584
76behavioral defense response (GO:0002209)3.19385333
77behavioral fear response (GO:0001662)3.19385333
78regulation of female receptivity (GO:0045924)3.19284405
79proline transport (GO:0015824)3.18571568
80activation of protein kinase A activity (GO:0034199)3.16740271
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14759110
82male meiosis I (GO:0007141)3.14131698
83regulation of neuronal synaptic plasticity (GO:0048168)3.13984283
84chromosome organization involved in meiosis (GO:0070192)3.13925433
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13433736
86regulation of cell proliferation involved in kidney development (GO:1901722)3.13096970
87DNA synthesis involved in DNA repair (GO:0000731)3.13051291
88transcription elongation from RNA polymerase I promoter (GO:0006362)3.12897598
89negative regulation of neurotransmitter transport (GO:0051589)3.11012957
90axonal fasciculation (GO:0007413)3.08675801
91positive regulation of synapse maturation (GO:0090129)3.08403521
92cellular potassium ion homeostasis (GO:0030007)3.07701392
93gamma-aminobutyric acid transport (GO:0015812)3.07050067
94cerebellar Purkinje cell differentiation (GO:0021702)3.06870955
95synaptic transmission, dopaminergic (GO:0001963)3.04381580
96regulation of neurotransmitter secretion (GO:0046928)3.03541030
97negative regulation of dendrite morphogenesis (GO:0050774)3.02290778
98cerebellar granule cell differentiation (GO:0021707)3.01789171
99synaptic vesicle endocytosis (GO:0048488)3.01557760
100protein localization to cilium (GO:0061512)3.00126437
101positive regulation of membrane potential (GO:0045838)3.00080880
102regulation of synaptic transmission, GABAergic (GO:0032228)2.99755448
103regulation of DNA damage checkpoint (GO:2000001)2.98841775
104regulation of p38MAPK cascade (GO:1900744)2.98274395
105histone lysine demethylation (GO:0070076)2.97584674
106male meiosis (GO:0007140)2.97566986
107regulation of synaptic plasticity (GO:0048167)2.96644651
108regulation of vesicle fusion (GO:0031338)2.96354788
109membrane depolarization (GO:0051899)2.95551661
110long-term memory (GO:0007616)2.94746740
111synaptic transmission (GO:0007268)2.92627990
112histone demethylation (GO:0016577)2.92337987
113vesicle transport along microtubule (GO:0047496)2.91756558
114innervation (GO:0060384)2.91467685
115synapse assembly (GO:0007416)2.91380330
116calcium ion-dependent exocytosis (GO:0017156)2.89849477
117mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89310625
118G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86297282
119positive regulation of neurotransmitter transport (GO:0051590)2.85307339
120response to cocaine (GO:0042220)2.84811763
121synaptonemal complex assembly (GO:0007130)2.84739022
122positive regulation of synaptic transmission (GO:0050806)2.84355447
123regulation of neurotransmitter transport (GO:0051588)2.84182151
124membrane depolarization during action potential (GO:0086010)2.83953394
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83855447
126intraspecies interaction between organisms (GO:0051703)2.82194961
127social behavior (GO:0035176)2.82194961
128synaptonemal complex organization (GO:0070193)2.81190696
129positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81028126
130chemosensory behavior (GO:0007635)2.80961130
131negative regulation of amine transport (GO:0051953)2.80895364
132prostate gland growth (GO:0060736)2.74036312
133negative regulation of meiotic cell cycle (GO:0051447)2.73548857
134positive regulation of insulin receptor signaling pathway (GO:0046628)2.71872622
135monoubiquitinated protein deubiquitination (GO:0035520)2.70275831
136negative regulation of inclusion body assembly (GO:0090084)2.68602817
137negative regulation of hormone biosynthetic process (GO:0032353)2.68186730
138keratinocyte development (GO:0003334)2.67060901
139negative regulation of neurotransmitter secretion (GO:0046929)2.66426361
140positive regulation of humoral immune response (GO:0002922)2.64676765
141histone H3-K36 demethylation (GO:0070544)2.64222554
142regulation of glomerulus development (GO:0090192)2.63489586
143protein demethylation (GO:0006482)2.61220141
144protein dealkylation (GO:0008214)2.61220141
145* nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.59841487
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.58858491
147positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.58582453
148regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.58582453
149regulation of dendritic spine morphogenesis (GO:0061001)2.55984967
150establishment of protein localization to Golgi (GO:0072600)2.55407337
151regulation of transforming growth factor beta1 production (GO:0032908)2.52985471
152regulation of meiotic cell cycle (GO:0051445)2.50978747
153viral mRNA export from host cell nucleus (GO:0046784)2.49646355
154sulfation (GO:0051923)2.48957395
155cAMP biosynthetic process (GO:0006171)2.48938221
156protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.46902146
157protein targeting to Golgi (GO:0000042)2.46424309
158regulation of cellular amide metabolic process (GO:0034248)2.45309867
159positive regulation of RNA splicing (GO:0033120)2.45292918
160positive regulation of T-helper 1 type immune response (GO:0002827)2.43980418
161negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.43932389
162phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42590206
163DNA integration (GO:0015074)2.41593911
164regulation of water loss via skin (GO:0033561)2.41254401
165retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39280139
166antimicrobial humoral response (GO:0019730)2.37770342
167cAMP catabolic process (GO:0006198)2.37174495
168cell differentiation in hindbrain (GO:0021533)2.36872473
169regulation of cell communication by electrical coupling (GO:0010649)2.36193913
170magnesium ion transport (GO:0015693)2.36046296
171transcription initiation from RNA polymerase I promoter (GO:0006361)2.36033286
172positive regulation of meiosis (GO:0045836)2.33427814
173negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.32699701
174cAMP metabolic process (GO:0046058)2.29654381
175protein K48-linked deubiquitination (GO:0071108)2.28882105
176cAMP-mediated signaling (GO:0019933)2.27411138
177regulation of histone H3-K9 methylation (GO:0051570)2.26807239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.39648932
2EZH2_22144423_ChIP-Seq_EOC_Human4.99122662
3GBX2_23144817_ChIP-Seq_PC3_Human4.32308552
4TAF15_26573619_Chip-Seq_HEK293_Human3.44353493
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.71963697
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54935325
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.54862941
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53609042
9REST_21632747_ChIP-Seq_MESCs_Mouse2.45919445
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43853856
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.38831380
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34733102
13FUS_26573619_Chip-Seq_HEK293_Human2.26443510
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23586413
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21671590
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21390161
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12092558
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09832584
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06536789
20P300_19829295_ChIP-Seq_ESCs_Human2.06455862
21SMAD4_21799915_ChIP-Seq_A2780_Human2.04975640
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.00077149
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.93168293
24ZNF274_21170338_ChIP-Seq_K562_Hela1.91928440
25AR_21572438_ChIP-Seq_LNCaP_Human1.90451164
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88544417
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.88096709
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87450203
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.85398500
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84821962
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82731957
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82230145
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79269100
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76228184
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76043522
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74603950
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74603950
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74166243
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69186956
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65370333
41TP53_16413492_ChIP-PET_HCT116_Human1.64814207
42VDR_22108803_ChIP-Seq_LS180_Human1.61872601
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60183007
44DROSHA_22980978_ChIP-Seq_HELA_Human1.59914860
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58931262
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57982483
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.57281027
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.52957593
49IGF1R_20145208_ChIP-Seq_DFB_Human1.51890486
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47809060
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47598453
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46833217
53AR_25329375_ChIP-Seq_VCAP_Human1.45639519
54ER_23166858_ChIP-Seq_MCF-7_Human1.43995973
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.43433252
56GATA1_22025678_ChIP-Seq_K562_Human1.43261391
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.43188847
58RNF2_27304074_Chip-Seq_NSC_Mouse1.41670995
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40819855
60EWS_26573619_Chip-Seq_HEK293_Human1.40776682
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.40547816
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39638845
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39555074
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36219304
65STAT3_23295773_ChIP-Seq_U87_Human1.35564889
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35130379
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.34083764
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33031303
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32605352
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29670317
71TCF4_23295773_ChIP-Seq_U87_Human1.29023734
72RXR_22108803_ChIP-Seq_LS180_Human1.28147608
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.25364569
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25119261
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.24995307
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22842969
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22199923
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.19933326
79AHR_22903824_ChIP-Seq_MCF-7_Human1.19760714
80IRF1_19129219_ChIP-ChIP_H3396_Human1.18577159
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18452641
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18272360
83RUNX2_22187159_ChIP-Seq_PCA_Human1.17902830
84BCAT_22108803_ChIP-Seq_LS180_Human1.16575354
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16325028
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13843193
87TP53_18474530_ChIP-ChIP_U2OS_Human1.13516502
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13036898
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12414246
90JUN_21703547_ChIP-Seq_K562_Human1.12067459
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.11413756
92* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11386610
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.11336612
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08995798
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08729155
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.08683683
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.07417394
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06971201
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06971201
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06380440
101KDM2B_26808549_Chip-Seq_REH_Human1.05921280
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.04188857
103* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03926781
104SOX9_26525672_Chip-Seq_HEART_Mouse1.03194629
105CBP_20019798_ChIP-Seq_JUKART_Human1.03163734
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03163734
107* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02822374
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00953755
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00925385
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00730019
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00460776
112REST_19997604_ChIP-ChIP_NEURONS_Mouse0.99599458
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.99197744
114PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98988132
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98387766
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97566641
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95758904
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.95521500
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94823939
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94471390
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94042018
122TAL1_26923725_Chip-Seq_HPCs_Mouse0.93097883
123* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92711329
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92436948
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91370476
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91370476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.28040569
2MP0004859_abnormal_synaptic_plasticity4.33951234
3MP0003635_abnormal_synaptic_transmissio3.69658028
4MP0009745_abnormal_behavioral_response3.37325312
5MP0009046_muscle_twitch3.20601205
6MP0000569_abnormal_digit_pigmentation3.10358614
7MP0001968_abnormal_touch/_nociception3.06546077
8MP0002064_seizures3.05057965
9MP0002063_abnormal_learning/memory/cond3.00186686
10MP0004270_analgesia2.91715135
11MP0010678_abnormal_skin_adnexa2.84377917
12MP0002572_abnormal_emotion/affect_behav2.83010094
13MP0002736_abnormal_nociception_after2.56684812
14MP0002272_abnormal_nervous_system2.55317714
15MP0006276_abnormal_autonomic_nervous2.53664345
16MP0001501_abnormal_sleep_pattern2.53108221
17MP0003122_maternal_imprinting2.52702850
18MP0000383_abnormal_hair_follicle2.51329918
19MP0002009_preneoplasia2.44569878
20MP0002837_dystrophic_cardiac_calcinosis2.40056446
21MP0001440_abnormal_grooming_behavior2.39686565
22MP0003787_abnormal_imprinting2.38911834
23MP0002822_catalepsy2.38666406
24MP0002796_impaired_skin_barrier2.35793111
25MP0002734_abnormal_mechanical_nocicepti2.35349150
26MP0002735_abnormal_chemical_nociception2.35314549
27MP0008057_abnormal_DNA_replication2.24692255
28MP0009780_abnormal_chondrocyte_physiolo2.17176289
29MP0001486_abnormal_startle_reflex2.15068664
30MP0005646_abnormal_pituitary_gland2.11263198
31MP0001529_abnormal_vocalization2.09820739
32MP0002067_abnormal_sensory_capabilities2.09265308
33MP0002160_abnormal_reproductive_system2.01628535
34MP0005423_abnormal_somatic_nervous1.89926087
35MP0001188_hyperpigmentation1.88045400
36MP0000579_abnormal_nail_morphology1.86520873
37MP0001984_abnormal_olfaction1.85249863
38MP0002733_abnormal_thermal_nociception1.84035307
39MP0001970_abnormal_pain_threshold1.80860330
40MP0005386_behavior/neurological_phenoty1.80067208
41MP0004924_abnormal_behavior1.80067208
42MP0008995_early_reproductive_senescence1.79607627
43MP0002184_abnormal_innervation1.72905672
44MP0005645_abnormal_hypothalamus_physiol1.72882932
45MP0002557_abnormal_social/conspecific_i1.70767126
46MP0001905_abnormal_dopamine_level1.64966213
47MP0002909_abnormal_adrenal_gland1.62410940
48MP0002876_abnormal_thyroid_physiology1.60691084
49MP0000013_abnormal_adipose_tissue1.58245339
50MP0005220_abnormal_exocrine_pancreas1.52046906
51MP0000778_abnormal_nervous_system1.51146610
52MP0004142_abnormal_muscle_tone1.43702324
53MP0000427_abnormal_hair_cycle1.41684525
54MP0010386_abnormal_urinary_bladder1.37820394
55MP0003879_abnormal_hair_cell1.34994845
56MP0003121_genomic_imprinting1.34797962
57MP0003941_abnormal_skin_development1.34376522
58MP0008569_lethality_at_weaning1.33309551
59MP0004811_abnormal_neuron_physiology1.30779424
60MP0002066_abnormal_motor_capabilities/c1.28178431
61MP0001177_atelectasis1.26629612
62MP0003123_paternal_imprinting1.25267483
63MP0000955_abnormal_spinal_cord1.24931291
64MP0003890_abnormal_embryonic-extraembry1.23795164
65MP0003221_abnormal_cardiomyocyte_apopto1.23653766
66MP0002210_abnormal_sex_determination1.19687366
67MP0002882_abnormal_neuron_morphology1.19256271
68MP0005501_abnormal_skin_physiology1.14852401
69MP0005379_endocrine/exocrine_gland_phen1.13949385
70MP0008058_abnormal_DNA_repair1.13275829
71MP0005275_abnormal_skin_tensile1.10316834
72MP0001502_abnormal_circadian_rhythm1.10008944
73MP0002928_abnormal_bile_duct1.07014419
74MP0003329_amyloid_beta_deposits1.06902276
75MP0000631_abnormal_neuroendocrine_gland1.06702011
76MP0006072_abnormal_retinal_apoptosis1.06090345
77MP0003656_abnormal_erythrocyte_physiolo1.05344379
78MP0001929_abnormal_gametogenesis1.05176793
79MP0001145_abnormal_male_reproductive1.04935381
80MP0001986_abnormal_taste_sensitivity1.04875643
81MP0005389_reproductive_system_phenotype1.04668707
82MP0005253_abnormal_eye_physiology1.03977883
83MP0008877_abnormal_DNA_methylation1.03927482
84MP0003633_abnormal_nervous_system1.03367861
85MP0004885_abnormal_endolymph1.01603636
86MP0000653_abnormal_sex_gland1.00889211
87MP0008872_abnormal_physiological_respon1.00502796
88MP0005083_abnormal_biliary_tract0.99576527
89MP0002152_abnormal_brain_morphology0.98770187
90MP0004043_abnormal_pH_regulation0.98153380
91MP0000751_myopathy0.97683935
92MP0003698_abnormal_male_reproductive0.96159929
93MP0000003_abnormal_adipose_tissue0.95856641
94MP0002069_abnormal_eating/drinking_beha0.93477976
95MP0005535_abnormal_body_temperature0.92076092
96MP0003183_abnormal_peptide_metabolism0.91427714
97MP0003631_nervous_system_phenotype0.91243871
98MP0005551_abnormal_eye_electrophysiolog0.88980229
99MP0002229_neurodegeneration0.88426408
100MP0010771_integument_phenotype0.87551705
101MP0001963_abnormal_hearing_physiology0.86759602
102MP0001664_abnormal_digestion0.85955631
103MP0003567_abnormal_fetal_cardiomyocyte0.85670136
104MP0004085_abnormal_heartbeat0.83745824
105MP0002638_abnormal_pupillary_reflex0.81959571
106MP0004145_abnormal_muscle_electrophysio0.79806007
107MP0004215_abnormal_myocardial_fiber0.79233907
108MP0005499_abnormal_olfactory_system0.78928978
109MP0005394_taste/olfaction_phenotype0.78928978
110MP0002163_abnormal_gland_morphology0.76142049
111MP0004484_altered_response_of0.75466425
112MP0004381_abnormal_hair_follicle0.75459722
113MP0003937_abnormal_limbs/digits/tail_de0.75079574
114MP0002971_abnormal_brown_adipose0.73527318
115MP0006035_abnormal_mitochondrial_morpho0.72492979
116MP0002752_abnormal_somatic_nervous0.68713429
117MP0008874_decreased_physiological_sensi0.67738771
118MP0004197_abnormal_fetal_growth/weight/0.67719747
119MP0001119_abnormal_female_reproductive0.67024002
120MP0000377_abnormal_hair_follicle0.67014224
121MP0004264_abnormal_extraembryonic_tissu0.66645946
122MP0003632_abnormal_nervous_system0.65732592
123MP0005409_darkened_coat_color0.65071650
124MP0000647_abnormal_sebaceous_gland0.63954211
125MP0009379_abnormal_foot_pigmentation0.62936267
126MP0004233_abnormal_muscle_weight0.62410861
127MP0004742_abnormal_vestibular_system0.61613769
128MP0001943_abnormal_respiration0.61264318
129MP0010234_abnormal_vibrissa_follicle0.59800781
130MP0005623_abnormal_meninges_morphology0.58654502
131MP0004858_abnormal_nervous_system0.58229256
132MP0005187_abnormal_penis_morphology0.56339283
133MP0002693_abnormal_pancreas_physiology0.55905286
134MP0001765_abnormal_ion_homeostasis0.55513789
135MP0000026_abnormal_inner_ear0.54777948
136MP0005410_abnormal_fertilization0.54767950
137MP0004036_abnormal_muscle_relaxation0.53929550
138MP0002751_abnormal_autonomic_nervous0.52889858
139MP0004130_abnormal_muscle_cell0.52813353

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.56261466
2Atonic seizures (HP:0010819)5.81914414
3Focal seizures (HP:0007359)4.99878149
4Visual hallucinations (HP:0002367)4.91335050
5Epileptic encephalopathy (HP:0200134)4.78464771
6Febrile seizures (HP:0002373)4.70939520
7Absence seizures (HP:0002121)4.55320677
8Abnormality of nail color (HP:0100643)4.49128180
9Hyperventilation (HP:0002883)4.29827138
10Dialeptic seizures (HP:0011146)4.18333419
11Oral leukoplakia (HP:0002745)4.06107967
12Myokymia (HP:0002411)3.57525699
13Progressive cerebellar ataxia (HP:0002073)3.43761611
14Generalized tonic-clonic seizures (HP:0002069)3.43604231
15Broad-based gait (HP:0002136)3.26239264
16Acute necrotizing encephalopathy (HP:0006965)3.24537096
17Neoplasm of the heart (HP:0100544)3.22681340
18Hypothermia (HP:0002045)3.20841874
19Lip pit (HP:0100267)3.19470545
20Gait imbalance (HP:0002141)3.18416863
21Impaired smooth pursuit (HP:0007772)3.13011273
22Progressive macrocephaly (HP:0004481)3.07984996
23Abnormal mitochondria in muscle tissue (HP:0008316)3.06758306
24Abnormal hair whorl (HP:0010721)3.06682073
25Anomalous pulmonary venous return (HP:0010772)3.06559937
26Genetic anticipation (HP:0003743)3.05186313
27Truncal ataxia (HP:0002078)3.01936629
28Congenital primary aphakia (HP:0007707)2.98423335
29Medial flaring of the eyebrow (HP:0010747)2.97275027
30Slow saccadic eye movements (HP:0000514)2.92532289
31Abnormality of the labia minora (HP:0012880)2.90036066
32Gaze-evoked nystagmus (HP:0000640)2.88217194
33Pheochromocytoma (HP:0002666)2.85483015
34Amblyopia (HP:0000646)2.83555327
35Impaired vibration sensation in the lower limbs (HP:0002166)2.81686016
36Gonadotropin excess (HP:0000837)2.81213465
37Vertebral arch anomaly (HP:0008438)2.80378332
38Nephrogenic diabetes insipidus (HP:0009806)2.78910026
39Epileptiform EEG discharges (HP:0011182)2.76270078
40Neuroendocrine neoplasm (HP:0100634)2.73050335
41Excessive salivation (HP:0003781)2.67928788
42Drooling (HP:0002307)2.67928788
43Limb dystonia (HP:0002451)2.67266926
44Mitochondrial inheritance (HP:0001427)2.66061848
45Medulloblastoma (HP:0002885)2.63089115
46Abnormality of ocular smooth pursuit (HP:0000617)2.61613199
47Progressive inability to walk (HP:0002505)2.60230597
48Hyperthyroidism (HP:0000836)2.59661369
49Diastasis recti (HP:0001540)2.57907262
50EEG with generalized epileptiform discharges (HP:0011198)2.55901566
51Scanning speech (HP:0002168)2.52712867
52Abnormality of the pulmonary veins (HP:0011718)2.51514216
53Resting tremor (HP:0002322)2.51408624
54Poor suck (HP:0002033)2.46572157
55Diplopia (HP:0000651)2.45031549
56Abnormality of binocular vision (HP:0011514)2.45031549
57Failure to thrive in infancy (HP:0001531)2.44869314
58Anxiety (HP:0000739)2.44327365
59Acute encephalopathy (HP:0006846)2.44176277
60Fair hair (HP:0002286)2.42189733
61Oligomenorrhea (HP:0000876)2.40981694
62Genital tract atresia (HP:0001827)2.39454782
63Hypsarrhythmia (HP:0002521)2.38704405
64Poor eye contact (HP:0000817)2.35439012
65Vaginal atresia (HP:0000148)2.32542487
66Dysdiadochokinesis (HP:0002075)2.31260904
67Depression (HP:0000716)2.31091079
68Protruding tongue (HP:0010808)2.30877440
69Specific learning disability (HP:0001328)2.28364809
70Abnormal eating behavior (HP:0100738)2.28154253
71Tongue fasciculations (HP:0001308)2.27238747
72Increased CSF lactate (HP:0002490)2.26595475
73Deformed sella turcica (HP:0002681)2.26073574
74Hamartoma (HP:0010566)2.25840386
75Impaired social interactions (HP:0000735)2.25813445
76Abnormal social behavior (HP:0012433)2.25813445
77Morphological abnormality of the pyramidal tract (HP:0002062)2.25220469
78Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.23583352
79Termporal pattern (HP:0011008)2.23269056
80Insidious onset (HP:0003587)2.23269056
81Skin pits (HP:0100276)2.23049962
82Polyphagia (HP:0002591)2.22432744
83Absent/shortened dynein arms (HP:0200106)2.20131540
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.20131540
85Abnormal ciliary motility (HP:0012262)2.18600346
86Absent speech (HP:0001344)2.18011995
87Neoplasm of the oral cavity (HP:0100649)2.16875558
88Ectropion (HP:0000656)2.16676291
89Gait ataxia (HP:0002066)2.16548428
90Poor coordination (HP:0002370)2.15673634
91Inability to walk (HP:0002540)2.13979306
92Bradykinesia (HP:0002067)2.08718145
93Palmar hyperkeratosis (HP:0010765)2.08292840
94Palmoplantar hyperkeratosis (HP:0000972)2.07729428
95Urinary bladder sphincter dysfunction (HP:0002839)2.05205566
96Hyperkalemia (HP:0002153)2.04599109
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03794402
98Lower limb muscle weakness (HP:0007340)2.03200766
99Blue irides (HP:0000635)2.02341810
100Degeneration of the lateral corticospinal tracts (HP:0002314)2.02142995
101Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02142995
102Abnormality of the labia majora (HP:0012881)1.99889445
103Parakeratosis (HP:0001036)1.99887014
104Hypoventilation (HP:0002791)1.98820126
105Delusions (HP:0000746)1.98415336
106Dysmetria (HP:0001310)1.98348348
107Short 4th metacarpal (HP:0010044)1.96060700
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96060700
109Shoulder girdle muscle weakness (HP:0003547)1.94989592
110Hyperinsulinemic hypoglycemia (HP:0000825)1.94682595
111Hepatocellular necrosis (HP:0001404)1.94576254
112Dysmetric saccades (HP:0000641)1.93771186
113Abnormality of the corticospinal tract (HP:0002492)1.93447234
114Broad alveolar ridges (HP:0000187)1.92961118
115Decreased circulating renin level (HP:0003351)1.92399263
116Cerebral inclusion bodies (HP:0100314)1.92218291
117Psychosis (HP:0000709)1.92069112
118Papillary thyroid carcinoma (HP:0002895)1.90391041
119Urinary urgency (HP:0000012)1.89480423
120Hemiparesis (HP:0001269)1.89314453
121Narrow nasal bridge (HP:0000446)1.88387412
122Action tremor (HP:0002345)1.88247457
123Abnormal respiratory motile cilium physiology (HP:0012261)1.87944888
124Abnormality of the nasal septum (HP:0000419)1.87427876
125Limb ataxia (HP:0002070)1.87275922
126Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.87066398
127Erythema (HP:0010783)1.86763034
128Hypoplastic labia majora (HP:0000059)1.85056888
129Impaired vibratory sensation (HP:0002495)1.83921342
130Labial hypoplasia (HP:0000066)1.83915805
131Increased circulating renin level (HP:0000848)1.83165166
132Abnormal pancreas size (HP:0012094)1.82993222
133Abnormality of the sella turcica (HP:0002679)1.82182666
134Neoplasm of the peripheral nervous system (HP:0100007)1.82177889
135Spastic paraplegia (HP:0001258)1.80245750
136Abnormal respiratory epithelium morphology (HP:0012253)1.79871844
137Abnormal respiratory motile cilium morphology (HP:0005938)1.79871844
138Carpal bone hypoplasia (HP:0001498)1.78477226
139Basal cell carcinoma (HP:0002671)1.78280763
140Agitation (HP:0000713)1.77815551
141Menstrual irregularities (HP:0000858)1.77379509
142Optic disc pallor (HP:0000543)1.77179513
143Retinal dysplasia (HP:0007973)1.76962042
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76882077
145Spastic gait (HP:0002064)1.76647066
146Wide intermamillary distance (HP:0006610)1.75963365
147Furrowed tongue (HP:0000221)1.75313676
148Widely spaced teeth (HP:0000687)1.75188387
149Short phalanx of the thumb (HP:0009660)1.74758293
150Amyotrophic lateral sclerosis (HP:0007354)1.74627054
151Muscle fibrillation (HP:0010546)1.73578468
152Paraplegia (HP:0010550)1.73030657
153Corneal erosion (HP:0200020)1.72588899
154Short chin (HP:0000331)1.71431020
155Intention tremor (HP:0002080)1.71136916
156Neoplasm of striated muscle (HP:0009728)1.71050707
157Abnormality of the renal collecting system (HP:0004742)1.69985511
158Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67538237
159Hemiplegia (HP:0002301)1.65641592
160Polydipsia (HP:0001959)1.65366379
161Abnormal drinking behavior (HP:0030082)1.65366379
162Chronic hepatic failure (HP:0100626)1.62719064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.17791149
2NTRK34.13871453
3MAP3K43.95825128
4MAP3K123.87658067
5MAP2K73.41465197
6BLK3.03952093
7EPHA42.99806752
8EPHA22.59199278
9MAP2K42.51153024
10PNCK2.48072838
11MAP3K92.47485587
12STK38L2.18319929
13AKT32.16880038
14TSSK62.09178002
15PLK22.01898255
16MINK11.90431090
17CDK191.77282610
18GRK51.75651263
19BRD41.64086544
20TLK11.62570677
21DAPK11.60886440
22MARK11.60570084
23DAPK21.57651908
24ACVR1B1.54094384
25RIPK41.46947518
26PDK31.45670644
27PDK41.45670644
28STK241.39309705
29EIF2AK31.39214884
30NTRK21.38958655
31CAMKK21.32810497
32NME11.31070989
33MAP3K21.30567467
34MAPK151.28214539
35ERBB31.20827780
36DYRK31.20689755
37KSR11.20359436
38MAPK131.18000882
39OXSR11.16924085
40WNK11.15814465
41BRSK21.15666904
42GRK71.15344187
43CCNB11.14587019
44WNK31.13335886
45CDK51.10721749
46TNIK1.09491838
47ARAF1.09268089
48INSRR1.08840970
49KSR21.07997037
50PRKCG1.07068588
51NEK91.05312634
52PINK11.05000190
53NTRK11.04661836
54CAMK2A1.00521550
55BMPR20.99499964
56CAMK2B0.97863548
57CAMK40.97122407
58SGK20.95999083
59PDK20.90923437
60PTK2B0.87613773
61DYRK1A0.86584063
62STK390.85807801
63SGK4940.84682758
64SGK2230.84682758
65MAP3K130.83139927
66FGFR30.81954865
67BCR0.80182476
68VRK10.78739440
69RPS6KA50.78458351
70GRK60.76131089
71FRK0.75941490
72OBSCN0.75907502
73FES0.75891835
74UHMK10.75526780
75FGR0.73465470
76FER0.73458893
77PRKAA10.73017188
78ADRBK20.73012748
79PRKCE0.72434090
80SIK30.70642926
81MAP4K20.70196134
82RET0.66962469
83MAPK70.66931574
84PAK60.66669579
85ADRBK10.66236744
86CDK60.65106727
87CAMK1G0.63691775
88SIK20.62143577
89PDGFRB0.61809408
90CSNK1G20.59639889
91CAMKK10.59143552
92CDK180.56423946
93SGK10.55614854
94PRPF4B0.55366140
95IRAK20.54185386
96CDK140.53046365
97LATS10.53006330
98CAMK2D0.51268832
99PHKG10.50777253
100PHKG20.50777253
101NLK0.50635427
102FGFR10.50318466
103MAP3K60.49943667
104FGFR20.49634267
105CDK150.49625287
106TNK20.48752963
107MET0.48734556
108PIM10.47872669
109CAMK2G0.46191493
110MYLK0.45946594
111STK30.45006922
112MAP3K50.44942310
113STK110.44271667
114ZAK0.44165242
115CDK30.42986812
116CDK120.42474214
117SGK30.41817872
118ERBB40.41401442
119WNK40.41334592
120PLK30.40821071
121CSNK1A1L0.40633786
122PRKACA0.40564978
123YES10.40341984
124BRAF0.40138156
125MAP2K10.40035423
126RAF10.39799915
127TAOK30.39408133
128CDK11A0.39406631
129MAPKAPK50.39129477
130CSNK1G10.38847073
131MAP3K70.38735948
132MKNK20.38561400
133PAK30.38291532
134DAPK30.37715273
135MAPK120.37544420
136IRAK10.36650716
137MKNK10.36583380
138STK380.35109418
139NEK60.34841132
140BMPR1B0.34801269
141PRKCH0.34788929
142PKN10.34330917
143CAMK10.33954540
144RPS6KA30.33897152
145RPS6KB10.33886538
146PDK10.31928361

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.12143443
2Synaptic vesicle cycle_Homo sapiens_hsa047213.52040240
3Collecting duct acid secretion_Homo sapiens_hsa049663.27450192
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.83785501
5Amphetamine addiction_Homo sapiens_hsa050312.65066611
6Long-term potentiation_Homo sapiens_hsa047202.64420823
7GABAergic synapse_Homo sapiens_hsa047272.62426325
8Oxidative phosphorylation_Homo sapiens_hsa001902.55845913
9Morphine addiction_Homo sapiens_hsa050322.41132007
10Circadian entrainment_Homo sapiens_hsa047132.36079699
11Olfactory transduction_Homo sapiens_hsa047402.35929398
12Taste transduction_Homo sapiens_hsa047422.32414123
13Dopaminergic synapse_Homo sapiens_hsa047282.21857867
14Glutamatergic synapse_Homo sapiens_hsa047242.14076657
15Vibrio cholerae infection_Homo sapiens_hsa051102.12289899
16Insulin secretion_Homo sapiens_hsa049112.00028969
17Renin secretion_Homo sapiens_hsa049241.88262378
18Serotonergic synapse_Homo sapiens_hsa047261.84617242
19Parkinsons disease_Homo sapiens_hsa050121.84471250
20Salivary secretion_Homo sapiens_hsa049701.82514256
21Alzheimers disease_Homo sapiens_hsa050101.74138054
22Long-term depression_Homo sapiens_hsa047301.71389600
23Cocaine addiction_Homo sapiens_hsa050301.67465482
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59642567
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55218359
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52564479
27Alcoholism_Homo sapiens_hsa050341.52228023
28Gastric acid secretion_Homo sapiens_hsa049711.50973925
29Cholinergic synapse_Homo sapiens_hsa047251.50843552
30Calcium signaling pathway_Homo sapiens_hsa040201.50677989
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48972340
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42624625
33Huntingtons disease_Homo sapiens_hsa050161.34934702
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34098790
35Oxytocin signaling pathway_Homo sapiens_hsa049211.32589282
36Ovarian steroidogenesis_Homo sapiens_hsa049131.31865131
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22709883
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18653617
39Cardiac muscle contraction_Homo sapiens_hsa042601.17918193
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17283863
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11681903
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11023594
43ABC transporters_Homo sapiens_hsa020101.10256565
44GnRH signaling pathway_Homo sapiens_hsa049121.10045925
45Ether lipid metabolism_Homo sapiens_hsa005651.09069224
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06068905
47Gap junction_Homo sapiens_hsa045401.04036593
48Hedgehog signaling pathway_Homo sapiens_hsa043401.03511825
49Basal transcription factors_Homo sapiens_hsa030221.01561061
50FoxO signaling pathway_Homo sapiens_hsa040681.01141180
51Estrogen signaling pathway_Homo sapiens_hsa049151.00961054
52Viral carcinogenesis_Homo sapiens_hsa052031.00917563
53Systemic lupus erythematosus_Homo sapiens_hsa053220.99655243
54Phototransduction_Homo sapiens_hsa047440.96906381
55Type II diabetes mellitus_Homo sapiens_hsa049300.94084020
56Linoleic acid metabolism_Homo sapiens_hsa005910.93078021
57cAMP signaling pathway_Homo sapiens_hsa040240.93049314
58Type I diabetes mellitus_Homo sapiens_hsa049400.92968041
59Glucagon signaling pathway_Homo sapiens_hsa049220.91670181
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85532706
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84408611
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.83627633
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81519411
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80862716
65Oocyte meiosis_Homo sapiens_hsa041140.80826094
66TGF-beta signaling pathway_Homo sapiens_hsa043500.80082390
67mRNA surveillance pathway_Homo sapiens_hsa030150.79520811
68Melanogenesis_Homo sapiens_hsa049160.79120950
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78823418
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77413449
71Rheumatoid arthritis_Homo sapiens_hsa053230.74846412
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74093294
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73091018
74Pyruvate metabolism_Homo sapiens_hsa006200.72299187
75Thyroid hormone synthesis_Homo sapiens_hsa049180.71884145
76Pancreatic secretion_Homo sapiens_hsa049720.69122187
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65456598
78Prolactin signaling pathway_Homo sapiens_hsa049170.64189999
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64110074
80ErbB signaling pathway_Homo sapiens_hsa040120.62590653
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62128654
82Axon guidance_Homo sapiens_hsa043600.61477495
83Sphingolipid metabolism_Homo sapiens_hsa006000.60988313
84Hippo signaling pathway_Homo sapiens_hsa043900.58650498
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58267506
86Glioma_Homo sapiens_hsa052140.56463799
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55752669
88Basal cell carcinoma_Homo sapiens_hsa052170.55464161
89Inositol phosphate metabolism_Homo sapiens_hsa005620.52129209
90Fanconi anemia pathway_Homo sapiens_hsa034600.51161633
91Bile secretion_Homo sapiens_hsa049760.50716485
92MAPK signaling pathway_Homo sapiens_hsa040100.50630659
93AMPK signaling pathway_Homo sapiens_hsa041520.49456415
94Selenocompound metabolism_Homo sapiens_hsa004500.49346637
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48008965
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46701663
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.45332576
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44077297
99p53 signaling pathway_Homo sapiens_hsa041150.42321272
100Protein export_Homo sapiens_hsa030600.42225458
101Dorso-ventral axis formation_Homo sapiens_hsa043200.41841408
102Regulation of autophagy_Homo sapiens_hsa041400.41006701
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40601181
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39387056
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38999437
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.37755589
107Tight junction_Homo sapiens_hsa045300.37490403
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36980286
109Circadian rhythm_Homo sapiens_hsa047100.36534617
110Ras signaling pathway_Homo sapiens_hsa040140.35389491
111Phagosome_Homo sapiens_hsa041450.34012519
112Prion diseases_Homo sapiens_hsa050200.33645595
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33480845
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33301443
115Insulin signaling pathway_Homo sapiens_hsa049100.32210980
116Dilated cardiomyopathy_Homo sapiens_hsa054140.30739946
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29072693
118Sulfur metabolism_Homo sapiens_hsa009200.28917181
119Butanoate metabolism_Homo sapiens_hsa006500.28173087
120Choline metabolism in cancer_Homo sapiens_hsa052310.27064989
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24831646
122African trypanosomiasis_Homo sapiens_hsa051430.22558667
123Wnt signaling pathway_Homo sapiens_hsa043100.21400879
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20583270
125Rap1 signaling pathway_Homo sapiens_hsa040150.20564180
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19506280
127mTOR signaling pathway_Homo sapiens_hsa041500.18920738
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.18570819
129Melanoma_Homo sapiens_hsa052180.13859659
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.13851637

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