EIF4A1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein polyglutamylation (GO:0018095)6.94248556
2chaperone-mediated protein transport (GO:0072321)6.73745373
3rRNA modification (GO:0000154)6.43493564
4rRNA methylation (GO:0031167)5.67582323
5regulation of skeletal muscle contraction (GO:0014819)5.58260490
6response to gravity (GO:0009629)5.46855838
7maturation of SSU-rRNA (GO:0030490)5.32708091
8mitochondrial respiratory chain complex I assembly (GO:0032981)5.20366484
9NADH dehydrogenase complex assembly (GO:0010257)5.20366484
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.20366484
11ribosomal small subunit biogenesis (GO:0042274)5.08927219
12fusion of sperm to egg plasma membrane (GO:0007342)4.98803252
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.94013488
14ATP synthesis coupled proton transport (GO:0015986)4.94013488
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.75572011
16sperm motility (GO:0030317)4.73031786
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.55199316
18protein complex biogenesis (GO:0070271)4.50346884
19mitochondrial respiratory chain complex assembly (GO:0033108)4.44081386
20proteasome assembly (GO:0043248)4.41185316
21GTP biosynthetic process (GO:0006183)4.37530704
22protein-cofactor linkage (GO:0018065)4.31242216
23viral transcription (GO:0019083)4.14406355
24grooming behavior (GO:0007625)4.06218276
25UTP biosynthetic process (GO:0006228)4.03856291
26plasma membrane fusion (GO:0045026)4.00665859
27ribosomal small subunit assembly (GO:0000028)3.99658701
28respiratory electron transport chain (GO:0022904)3.97502626
29DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.96899658
30DNA deamination (GO:0045006)3.92878926
31prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.91918640
32translational elongation (GO:0006414)3.89978792
33electron transport chain (GO:0022900)3.89782676
34translational termination (GO:0006415)3.85559409
35UTP metabolic process (GO:0046051)3.77415807
36DNA damage response, signal transduction resulting in transcription (GO:0042772)3.77203917
37regulation of centriole replication (GO:0046599)3.73395264
38protein targeting to mitochondrion (GO:0006626)3.67571894
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.67104273
40negative regulation of JAK-STAT cascade (GO:0046426)3.64554705
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.64255096
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.64054026
43negative regulation of muscle hypertrophy (GO:0014741)3.62702455
44RNA destabilization (GO:0050779)3.62321393
45outer ear morphogenesis (GO:0042473)3.59778270
46cellular response to exogenous dsRNA (GO:0071360)3.55616341
47regulation of cilium movement (GO:0003352)3.53510100
48sperm-egg recognition (GO:0035036)3.49054588
49DNA packaging (GO:0006323)3.47512719
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46004267
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46004267
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.45276345
53ATP biosynthetic process (GO:0006754)3.44864347
54cardiovascular system development (GO:0072358)3.44543530
55CTP metabolic process (GO:0046036)3.42066244
56CTP biosynthetic process (GO:0006241)3.42066244
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.37852405
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32452355
59regulation of DNA endoreduplication (GO:0032875)3.30926152
60multicellular organism reproduction (GO:0032504)3.30766458
61skeletal muscle adaptation (GO:0043501)3.29928537
62chromosome condensation (GO:0030261)3.29573431
63spermatid development (GO:0007286)3.26093598
64protein neddylation (GO:0045116)3.24781390
65pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.23049415
66establishment of protein localization to mitochondrion (GO:0072655)3.22644397
67pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.22252108
68cotranslational protein targeting to membrane (GO:0006613)3.21317620
69translation (GO:0006412)3.21201384
70pseudouridine synthesis (GO:0001522)3.21130105
71striated muscle atrophy (GO:0014891)3.20867300
72pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.19455636
73protein targeting to ER (GO:0045047)3.19261802
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.17948748
75termination of RNA polymerase III transcription (GO:0006386)3.17948748
76cellular component biogenesis (GO:0044085)3.17485281
77protein localization to mitochondrion (GO:0070585)3.16464180
78binding of sperm to zona pellucida (GO:0007339)3.15936788
79cell wall macromolecule metabolic process (GO:0044036)3.14821837
80rRNA processing (GO:0006364)3.13959063
81guanosine-containing compound biosynthetic process (GO:1901070)3.13289752
82acrosome reaction (GO:0007340)3.11456480
83cellular protein complex disassembly (GO:0043624)3.09823870
84pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.07819947
85regulation of germinal center formation (GO:0002634)3.07719345
86muscle atrophy (GO:0014889)3.05727604
87rRNA metabolic process (GO:0016072)3.05251275
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02552200
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01662663
90protein localization to endoplasmic reticulum (GO:0070972)3.00749011
91establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00537178
92nucleoside triphosphate biosynthetic process (GO:0009142)2.98062014
93ribonucleoprotein complex biogenesis (GO:0022613)2.94519622
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93523134
95viral life cycle (GO:0019058)2.92676078
96reproduction (GO:0000003)2.92560686
97protein maturation by protein folding (GO:0022417)2.90360895
98ubiquinone biosynthetic process (GO:0006744)2.86155717
99mesonephros development (GO:0001823)2.85759932
100positive regulation of interleukin-8 secretion (GO:2000484)2.84204750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.77201023
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.04414050
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.78140581
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11803245
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06335115
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02506087
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.79870084
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.75240191
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.62516521
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56734138
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55456738
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.54032820
13YY1_21170310_ChIP-Seq_MESCs_Mouse2.50024637
14VDR_22108803_ChIP-Seq_LS180_Human2.32303679
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.31902267
16EZH2_22144423_ChIP-Seq_EOC_Human2.12928020
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11424880
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02602361
19XRN2_22483619_ChIP-Seq_HELA_Human2.01767436
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97456902
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84544210
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80928336
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79101742
24VDR_23849224_ChIP-Seq_CD4+_Human1.74205948
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72439773
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70719499
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.69398288
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68057562
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.67579530
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67407794
31CIITA_25753668_ChIP-Seq_RAJI_Human1.64149777
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.63502230
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63425411
34TTF2_22483619_ChIP-Seq_HELA_Human1.63377246
35YY1_22570637_ChIP-Seq_MALME-3M_Human1.62197206
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58892830
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.58461424
38BCL6_27268052_Chip-Seq_Bcells_Human1.52611771
39FUS_26573619_Chip-Seq_HEK293_Human1.52115777
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50505204
41FOXP3_21729870_ChIP-Seq_TREG_Human1.50321513
42ERA_21632823_ChIP-Seq_H3396_Human1.48296037
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48136535
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47287340
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41654003
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40883786
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.39250987
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.37220297
49EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.35599349
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34881821
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34132446
52CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33775448
53GABP_19822575_ChIP-Seq_HepG2_Human1.32308881
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27558275
55NANOG_20526341_ChIP-Seq_ESCs_Human1.26814726
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25846236
57P68_20966046_ChIP-Seq_HELA_Human1.25779362
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24039205
59BCOR_27268052_Chip-Seq_Bcells_Human1.21606645
60TAF2_19829295_ChIP-Seq_ESCs_Human1.20570212
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.18285661
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.15339779
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13903075
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11782090
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11375932
66DCP1A_22483619_ChIP-Seq_HELA_Human1.10872229
67E2F1_20622854_ChIP-Seq_HELA_Human1.10211298
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10206842
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09932187
70P300_27268052_Chip-Seq_Bcells_Human1.06620256
71WDR5_24793694_ChIP-Seq_LNCAP_Human1.06449871
72PHF8_20622854_ChIP-Seq_HELA_Human1.05326742
73CTCF_20526341_ChIP-Seq_ESCs_Human1.04843526
74ERG_20517297_ChIP-Seq_VCAP_Human1.03691976
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02878370
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02469365
77IRF1_19129219_ChIP-ChIP_H3396_Human1.01293093
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00842793
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00243635
80STAT1_20625510_ChIP-Seq_HELA_Human0.99916699
81RAC3_21632823_ChIP-Seq_H3396_Human0.98727706
82TP53_20018659_ChIP-ChIP_R1E_Mouse0.97704031
83P53_21459846_ChIP-Seq_SAOS-2_Human0.97345503
84MYC_18940864_ChIP-ChIP_HL60_Human0.96513599
85MYC_19829295_ChIP-Seq_ESCs_Human0.95070823
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94816274
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.94624453
88E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91813483
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91412499
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89384432
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89315879
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88752797
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.88116710
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87935046
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.85893439
96TAF15_26573619_Chip-Seq_HEK293_Human0.85201334
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85037030
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84929357
99SA1_27219007_Chip-Seq_Bcells_Human0.84911007
100CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83067184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.61800831
2MP0002138_abnormal_hepatobiliary_system3.43993735
3MP0000678_abnormal_parathyroid_gland3.23141519
4MP0000049_abnormal_middle_ear3.10526021
5MP0001348_abnormal_lacrimal_gland3.01040935
6MP0009053_abnormal_anal_canal2.48802321
7MP0005084_abnormal_gallbladder_morpholo2.47326178
8MP0005670_abnormal_white_adipose2.39570390
9MP0003878_abnormal_ear_physiology2.33124257
10MP0005377_hearing/vestibular/ear_phenot2.33124257
11MP0002160_abnormal_reproductive_system2.31149343
12MP0005379_endocrine/exocrine_gland_phen2.13254938
13MP0006292_abnormal_olfactory_placode1.99015688
14MP0008789_abnormal_olfactory_epithelium1.91824439
15MP0005646_abnormal_pituitary_gland1.87999500
16MP0006072_abnormal_retinal_apoptosis1.87575407
17MP0003698_abnormal_male_reproductive1.81918140
18MP0005671_abnormal_response_to1.80328840
19MP0001929_abnormal_gametogenesis1.76255199
20MP0008058_abnormal_DNA_repair1.75481172
21MP0004145_abnormal_muscle_electrophysio1.74412925
22MP0004134_abnormal_chest_morphology1.72392659
23MP0003718_maternal_effect1.71949198
24MP0010030_abnormal_orbit_morphology1.70330386
25MP0005389_reproductive_system_phenotype1.67414255
26MP0004036_abnormal_muscle_relaxation1.66540189
27MP0008932_abnormal_embryonic_tissue1.64663030
28MP0003879_abnormal_hair_cell1.59587547
29MP0005083_abnormal_biliary_tract1.53727636
30MP0001905_abnormal_dopamine_level1.49159215
31MP0009379_abnormal_foot_pigmentation1.48783138
32MP0002108_abnormal_muscle_morphology1.48617148
33MP0000747_muscle_weakness1.43809590
34MP0010368_abnormal_lymphatic_system1.37324102
35MP0004885_abnormal_endolymph1.35102723
36MP0003786_premature_aging1.34392323
37MP0002282_abnormal_trachea_morphology1.34194966
38MP0002210_abnormal_sex_determination1.33957178
39MP0001968_abnormal_touch/_nociception1.32035080
40MP0002269_muscular_atrophy1.31040601
41MP0003077_abnormal_cell_cycle1.30340072
42MP0009250_abnormal_appendicular_skeleto1.29012782
43MP0001879_abnormal_lymphatic_vessel1.28596113
44MP0005257_abnormal_intraocular_pressure1.24580150
45MP0003646_muscle_fatigue1.24053094
46MP0004957_abnormal_blastocyst_morpholog1.22348662
47MP0002089_abnormal_postnatal_growth/wei1.19002253
48MP0001485_abnormal_pinna_reflex1.14603414
49MP0006036_abnormal_mitochondrial_physio1.14571826
50MP0003806_abnormal_nucleotide_metabolis1.14266094
51MP0001145_abnormal_male_reproductive1.13521908
52MP0002876_abnormal_thyroid_physiology1.13420623
53MP0000467_abnormal_esophagus_morphology1.12596258
54MP0001919_abnormal_reproductive_system1.10562587
55MP0002095_abnormal_skin_pigmentation1.09489803
56MP0000653_abnormal_sex_gland1.09480828
57MP0002161_abnormal_fertility/fecundity1.07752221
58MP0003693_abnormal_embryo_hatching1.03343980
59MP0000759_abnormal_skeletal_muscle1.02616426
60MP0008872_abnormal_physiological_respon1.02117676
61MP0009765_abnormal_xenobiotic_induced1.01311066
62MP0003938_abnormal_ear_development1.00257132
63MP0001963_abnormal_hearing_physiology0.93370635
64MP0000230_abnormal_systemic_arterial0.91675741
65MP0008775_abnormal_heart_ventricle0.91238729
66MP0003937_abnormal_limbs/digits/tail_de0.90720375
67MP0001529_abnormal_vocalization0.89868594
68MP0003183_abnormal_peptide_metabolism0.89634444
69MP0004133_heterotaxia0.89300815
70MP0002163_abnormal_gland_morphology0.87874538
71MP0002736_abnormal_nociception_after0.87712664
72MP0005187_abnormal_penis_morphology0.87103331
73MP0002938_white_spotting0.86379049
74MP0002932_abnormal_joint_morphology0.86327903
75MP0000750_abnormal_muscle_regeneration0.86276629
76MP0000749_muscle_degeneration0.84786338
77MP0002148_abnormal_hypersensitivity_rea0.84309163
78MP0000163_abnormal_cartilage_morphology0.83607087
79MP0000631_abnormal_neuroendocrine_gland0.82596184
80MP0003959_abnormal_lean_body0.79813919
81MP0001765_abnormal_ion_homeostasis0.76916676
82MP0000026_abnormal_inner_ear0.76912339
83MP0005394_taste/olfaction_phenotype0.76530472
84MP0005499_abnormal_olfactory_system0.76530472
85MP0002109_abnormal_limb_morphology0.75037793
86MP0005167_abnormal_blood-brain_barrier0.74799666
87MP0000685_abnormal_immune_system0.74367464
88MP0002234_abnormal_pharynx_morphology0.74136572
89MP0001440_abnormal_grooming_behavior0.72723701
90MP0009745_abnormal_behavioral_response0.72507733
91MP0002115_abnormal_skeleton_extremities0.71039784
92MP0004142_abnormal_muscle_tone0.70970900
93MP0008007_abnormal_cellular_replicative0.69206068
94MP0001486_abnormal_startle_reflex0.68783408
95MP0000613_abnormal_salivary_gland0.68469315
96MP0006276_abnormal_autonomic_nervous0.66669588
97MP0002837_dystrophic_cardiac_calcinosis0.65669979
98MP0001119_abnormal_female_reproductive0.64897059
99MP0002822_catalepsy0.64546953
100MP0009780_abnormal_chondrocyte_physiolo0.63907492

Predicted human phenotypes

RankGene SetZ-score
1Conjunctival hamartoma (HP:0100780)5.35012835
2Acute necrotizing encephalopathy (HP:0006965)4.26415639
3Severe visual impairment (HP:0001141)4.22998131
4Abnormal mitochondria in muscle tissue (HP:0008316)3.86742157
5Absent/shortened dynein arms (HP:0200106)3.86154514
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.86154514
7Mitochondrial inheritance (HP:0001427)3.78946598
8Hamartoma of the eye (HP:0010568)3.68905235
9Acute encephalopathy (HP:0006846)3.61871794
10Abnormality of the middle phalanges of the toes (HP:0010183)3.57352438
11Progressive macrocephaly (HP:0004481)3.47321845
12Absent phalangeal crease (HP:0006109)3.40437194
13Increased CSF lactate (HP:0002490)3.31086479
14Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.17830197
15Symphalangism affecting the phalanges of the hand (HP:0009773)3.17021023
16Abnormal umbilical cord blood vessels (HP:0011403)3.14250138
17Single umbilical artery (HP:0001195)3.14250138
18Abnormality of the fetal cardiovascular system (HP:0010948)3.14250138
19Hepatocellular necrosis (HP:0001404)3.11134314
20Abnormality of the phalanges of the 2nd finger (HP:0009541)3.07426670
21Abnormality of the 4th metacarpal (HP:0010012)3.07057498
22Abnormality of the phalanges of the 5th finger (HP:0004213)3.02262995
23Absent thumb (HP:0009777)2.87532179
24Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.80624408
25Hepatic necrosis (HP:0002605)2.77965742
26Hypoplasia of the radius (HP:0002984)2.73613703
27Tubulointerstitial nephritis (HP:0001970)2.70310665
28Palpebral edema (HP:0100540)2.70104337
29Bone cyst (HP:0012062)2.67986797
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66455301
31Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.65563154
32Meningioma (HP:0002858)2.64827705
33Cerebral edema (HP:0002181)2.64064538
343-Methylglutaconic aciduria (HP:0003535)2.59166805
35Abnormal finger flexion creases (HP:0006143)2.58739045
36Fibular aplasia (HP:0002990)2.57492075
37Pancreatic cysts (HP:0001737)2.56095461
38Reticulocytopenia (HP:0001896)2.45785166
39Renal Fanconi syndrome (HP:0001994)2.42622785
40Abnormal number of erythroid precursors (HP:0012131)2.39197537
41Reduced subcutaneous adipose tissue (HP:0003758)2.39186812
42Increased serum lactate (HP:0002151)2.38560234
43Forearm undergrowth (HP:0009821)2.34386507
44Pendular nystagmus (HP:0012043)2.33482637
45Lactic acidosis (HP:0003128)2.31776607
46Abnormality of the proximal phalanges of the hand (HP:0009834)2.31503947
47Abnormal respiratory motile cilium morphology (HP:0005938)2.31309749
48Abnormal respiratory epithelium morphology (HP:0012253)2.31309749
49Furrowed tongue (HP:0000221)2.30759528
50Short femoral neck (HP:0100864)2.28772326
51Respiratory failure (HP:0002878)2.25475618
52Short middle phalanx of the 5th finger (HP:0004220)2.24803969
53Angiofibromas (HP:0010615)2.23521718
54Adenoma sebaceum (HP:0009720)2.23521718
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22115027
56Paralysis (HP:0003470)2.20841980
57Abnormality of cells of the erythroid lineage (HP:0012130)2.20790642
58Pancreatic fibrosis (HP:0100732)2.19649001
59Esophageal atresia (HP:0002032)2.19556084
60Abnormal rod and cone electroretinograms (HP:0008323)2.17306305
61Abnormality of macular pigmentation (HP:0008002)2.17008611
62Broad distal phalanx of finger (HP:0009836)2.15845110
63Microretrognathia (HP:0000308)2.15665908
64Cavernous hemangioma (HP:0001048)2.11851180
65Aplasia/Hypoplasia of the fibula (HP:0006492)2.08505536
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07461150
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07461150
68Exercise intolerance (HP:0003546)2.05476374
69Molar tooth sign on MRI (HP:0002419)2.02424751
70Abnormality of midbrain morphology (HP:0002418)2.02424751
71Syringomyelia (HP:0003396)2.02042550
72Spinal cord lesions (HP:0100561)2.02042550
73Broad hallux (HP:0010055)2.01140657
74Ulnar deviation of the wrist (HP:0003049)1.97135706
75Abnormality of the umbilical cord (HP:0010881)1.94785400
76Short tibia (HP:0005736)1.94774478
77Abnormality of the phalanges of the hallux (HP:0010057)1.94717237
78Increased hepatocellular lipid droplets (HP:0006565)1.94617788
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93112473
80Distal arthrogryposis (HP:0005684)1.92982930
81Anencephaly (HP:0002323)1.92922134
82Hypoplasia of the uterus (HP:0000013)1.92823010
83Mesomelia (HP:0003027)1.92172462
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91115733
85Abnormality of alanine metabolism (HP:0010916)1.91115733
86Hyperalaninemia (HP:0003348)1.91115733
87Aplasia/hypoplasia of the uterus (HP:0008684)1.90472771
88Hyperuricemia (HP:0002149)1.89611094
89Increased purine levels (HP:0004368)1.89611094
90Male infertility (HP:0003251)1.89342908
91Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.87898539
92Abnormal ciliary motility (HP:0012262)1.86595058
93Increased intramyocellular lipid droplets (HP:0012240)1.85080319
94Optic disc pallor (HP:0000543)1.83238136
95Occipital encephalocele (HP:0002085)1.83113234
96Round ear (HP:0100830)1.80407236
97Elevated erythrocyte sedimentation rate (HP:0003565)1.79885414
98Ectopic kidney (HP:0000086)1.79496953
99Abnormal respiratory motile cilium physiology (HP:0012261)1.79485801
100Progressive muscle weakness (HP:0003323)1.78725251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME28.90182889
2TIE14.56673726
3PLK43.75674870
4VRK23.51583547
5INSRR3.35473888
6BCKDK3.05576201
7TESK22.71023676
8NUAK12.42315058
9TESK12.31371911
10PHKG21.85078171
11PHKG11.85078171
12TLK11.60928807
13TAF11.56365628
14MAP3K111.46756529
15LIMK11.38512390
16ICK1.35705649
17MAPKAPK31.34528216
18STK161.30492910
19AURKA1.30465600
20PLK21.29577022
21MAP2K21.28507564
22PDK21.28236379
23MAP4K21.25237722
24ZAK1.23590574
25VRK11.19940437
26MUSK1.19633995
27CSNK1G31.11222569
28IKBKB1.06080871
29GRK61.02130521
30SRPK11.01058021
31CSNK1A1L0.94304486
32OBSCN0.92664088
33FES0.90120603
34RPS6KA40.88280838
35DYRK20.88149048
36PIK3CG0.86499361
37LMTK20.84627909
38CDK70.84328979
39ADRBK20.83962614
40CSNK1G20.83145033
41ABL20.80615858
42MAP3K120.76846794
43WNK40.75786653
44GRK10.74928887
45CCNB10.74219818
46TRIM280.73351256
47DYRK30.70824318
48PIM20.70723092
49NEK10.70181022
50TAOK30.70148820
51CSNK1G10.68389870
52KDR0.68068144
53PINK10.67725600
54BUB10.67266205
55DAPK10.65992460
56CDK190.64761607
57RPS6KA50.62656451
58CHEK20.61988633
59CDC70.60339371
60TYRO30.57810587
61WNK10.55717661
62BRD40.53427859
63PAK60.52403228
64SCYL20.51808288
65IKBKE0.50981120
66BRSK10.48801834
67CDK40.47896476
68MAP2K70.47461242
69EIF2AK20.46816568
70TEC0.45841200
71NME10.44504588
72ARAF0.41377684
73MAP3K80.41295828
74PDPK10.40400074
75MAPK110.40329631
76PRKG20.39517694
77LRRK20.38939374
78CHEK10.38833595
79NEK90.38219607
80PIM10.37936376
81CSNK2A10.35102130
82ILK0.34126882
83AKT20.33183688
84PDK10.33125492
85IRAK10.32537562
86PAK10.29666023
87CSF1R0.28017793
88RPS6KL10.27696422
89RPS6KC10.27696422
90RPS6KA60.27589920
91TBK10.27242251
92PLK10.26637882
93RPS6KA10.26624183
94KIT0.26323891
95MAP3K140.25780129
96PRKACA0.25529007
97ATR0.25233495
98CSNK1A10.23707214
99DDR20.23622146
100RPS6KA20.23250304

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.26877095
2Oxidative phosphorylation_Homo sapiens_hsa001904.61483254
3Parkinsons disease_Homo sapiens_hsa050124.10410019
4Proteasome_Homo sapiens_hsa030503.44343096
5Huntingtons disease_Homo sapiens_hsa050163.29619963
6Alzheimers disease_Homo sapiens_hsa050103.02636763
7RNA polymerase_Homo sapiens_hsa030202.83988924
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.71559042
9DNA replication_Homo sapiens_hsa030302.68831089
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.45256749
11Cardiac muscle contraction_Homo sapiens_hsa042602.17848224
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17799165
13Base excision repair_Homo sapiens_hsa034102.10298198
14Spliceosome_Homo sapiens_hsa030402.08517730
15Pyrimidine metabolism_Homo sapiens_hsa002402.03311386
16Sulfur relay system_Homo sapiens_hsa041221.99143115
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.98489568
18Asthma_Homo sapiens_hsa053101.67260054
19RNA transport_Homo sapiens_hsa030131.64139882
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63298192
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59973610
22Fanconi anemia pathway_Homo sapiens_hsa034601.59890525
23Mismatch repair_Homo sapiens_hsa034301.56810806
24One carbon pool by folate_Homo sapiens_hsa006701.47911136
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.45273439
26Purine metabolism_Homo sapiens_hsa002301.42333948
27Nucleotide excision repair_Homo sapiens_hsa034201.30665141
28Homologous recombination_Homo sapiens_hsa034401.28978428
29RNA degradation_Homo sapiens_hsa030181.24561737
30Olfactory transduction_Homo sapiens_hsa047401.15808652
31Folate biosynthesis_Homo sapiens_hsa007901.04258288
32Protein export_Homo sapiens_hsa030601.00583110
33Hedgehog signaling pathway_Homo sapiens_hsa043401.00157405
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95313623
35Phototransduction_Homo sapiens_hsa047440.83920083
36Allograft rejection_Homo sapiens_hsa053300.82507137
37Basal transcription factors_Homo sapiens_hsa030220.80590089
38Systemic lupus erythematosus_Homo sapiens_hsa053220.77451456
39Autoimmune thyroid disease_Homo sapiens_hsa053200.75989826
40Antigen processing and presentation_Homo sapiens_hsa046120.75298030
41Herpes simplex infection_Homo sapiens_hsa051680.73298166
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70450455
43Graft-versus-host disease_Homo sapiens_hsa053320.70095862
44Type I diabetes mellitus_Homo sapiens_hsa049400.69429613
45Metabolic pathways_Homo sapiens_hsa011000.67636622
46Glutathione metabolism_Homo sapiens_hsa004800.67463546
47Oocyte meiosis_Homo sapiens_hsa041140.64804559
48Phenylalanine metabolism_Homo sapiens_hsa003600.64576028
49Salivary secretion_Homo sapiens_hsa049700.59477068
50Renin-angiotensin system_Homo sapiens_hsa046140.59264429
51Sulfur metabolism_Homo sapiens_hsa009200.56955178
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54921186
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.54680490
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54657187
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53732398
56Rheumatoid arthritis_Homo sapiens_hsa053230.52221629
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44559605
58Basal cell carcinoma_Homo sapiens_hsa052170.43503174
59Epstein-Barr virus infection_Homo sapiens_hsa051690.42613801
60Chemical carcinogenesis_Homo sapiens_hsa052040.42245437
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41731955
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40477227
63Peroxisome_Homo sapiens_hsa041460.38493672
64Fatty acid elongation_Homo sapiens_hsa000620.38087873
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37880780
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.35943400
67Arginine and proline metabolism_Homo sapiens_hsa003300.35428435
68Regulation of autophagy_Homo sapiens_hsa041400.35247543
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33548156
70Tyrosine metabolism_Homo sapiens_hsa003500.33174876
71Nitrogen metabolism_Homo sapiens_hsa009100.32366097
72Fat digestion and absorption_Homo sapiens_hsa049750.31526577
73Fatty acid biosynthesis_Homo sapiens_hsa000610.31432694
74Carbon metabolism_Homo sapiens_hsa012000.31254159
75Tight junction_Homo sapiens_hsa045300.30695559
76Morphine addiction_Homo sapiens_hsa050320.28515510
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.28223792
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28133637
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27045865
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25979952
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25971604
82Arachidonic acid metabolism_Homo sapiens_hsa005900.25568605
83Retinol metabolism_Homo sapiens_hsa008300.24541337
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24212192
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24023191
86Tryptophan metabolism_Homo sapiens_hsa003800.23830117
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23165533
88Gastric acid secretion_Homo sapiens_hsa049710.22112143
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21997580
90HTLV-I infection_Homo sapiens_hsa051660.21708083
91Biosynthesis of amino acids_Homo sapiens_hsa012300.21265551
92Viral myocarditis_Homo sapiens_hsa054160.18902589
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18502564
94mRNA surveillance pathway_Homo sapiens_hsa030150.18411433
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18343597
96Pancreatic secretion_Homo sapiens_hsa049720.17848897
97Melanoma_Homo sapiens_hsa052180.17327060
98Oxytocin signaling pathway_Homo sapiens_hsa049210.16290570
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.15704969
100Linoleic acid metabolism_Homo sapiens_hsa005910.15517257

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