EIF3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1macromolecular complex disassembly (GO:0032984)5.04452215
2DNA unwinding involved in DNA replication (GO:0006268)4.82928603
3nuclear-transcribed mRNA catabolic process (GO:0000956)4.67256829
4DNA strand elongation involved in DNA replication (GO:0006271)4.64681140
5nucleobase biosynthetic process (GO:0046112)4.63604805
6ribosomal small subunit assembly (GO:0000028)4.53642335
7* formation of translation preinitiation complex (GO:0001731)4.53362838
8protein targeting to membrane (GO:0006612)4.46545105
9DNA strand elongation (GO:0022616)4.43808596
10mRNA catabolic process (GO:0006402)4.43287681
11DNA replication initiation (GO:0006270)4.41544373
12IMP biosynthetic process (GO:0006188)4.40434639
13protein localization to kinetochore (GO:0034501)4.39758896
14maturation of SSU-rRNA (GO:0030490)4.31577018
15purine nucleobase biosynthetic process (GO:0009113)4.26545616
16establishment of integrated proviral latency (GO:0075713)4.25644292
17folic acid-containing compound biosynthetic process (GO:0009396)4.24079486
18telomere maintenance via semi-conservative replication (GO:0032201)4.22601617
19mitotic nuclear envelope disassembly (GO:0007077)4.15828414
20RNA catabolic process (GO:0006401)4.11247176
21nuclear pore organization (GO:0006999)4.00087657
22IMP metabolic process (GO:0046040)3.85569075
23viral transcription (GO:0019083)3.84676082
24DNA replication-dependent nucleosome assembly (GO:0006335)3.84408648
25DNA replication-dependent nucleosome organization (GO:0034723)3.84408648
26membrane disassembly (GO:0030397)3.83430507
27nuclear envelope disassembly (GO:0051081)3.83430507
28translational termination (GO:0006415)3.81669744
29mitotic metaphase plate congression (GO:0007080)3.80599320
30telomere maintenance via recombination (GO:0000722)3.79616383
31DNA ligation (GO:0006266)3.76633247
32nuclear pore complex assembly (GO:0051292)3.74051071
33DNA replication checkpoint (GO:0000076)3.72404956
34ribosome assembly (GO:0042255)3.71887555
35ribosomal large subunit biogenesis (GO:0042273)3.70442302
36mitotic recombination (GO:0006312)3.66794112
37ribosome biogenesis (GO:0042254)3.61710191
38translational elongation (GO:0006414)3.59773929
39protein localization to chromosome, centromeric region (GO:0071459)3.58061344
40* translational initiation (GO:0006413)3.57071316
41ribonucleoprotein complex biogenesis (GO:0022613)3.56324916
42telomere maintenance via telomere lengthening (GO:0010833)3.50564380
43ribosomal small subunit biogenesis (GO:0042274)3.44721072
44metaphase plate congression (GO:0051310)3.37474172
45CENP-A containing nucleosome assembly (GO:0034080)3.36584556
46chromatin remodeling at centromere (GO:0031055)3.36435953
47cullin deneddylation (GO:0010388)3.36235222
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35329489
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32245893
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32040997
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.28540293
52mitotic chromosome condensation (GO:0007076)3.28538187
53regulation of spindle organization (GO:0090224)3.28199759
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26208150
55non-recombinational repair (GO:0000726)3.23953318
56double-strand break repair via nonhomologous end joining (GO:0006303)3.23953318
57DNA duplex unwinding (GO:0032508)3.22887668
58cotranslational protein targeting to membrane (GO:0006613)3.22173375
59DNA geometric change (GO:0032392)3.21470082
60protein targeting to ER (GO:0045047)3.21464994
61GMP metabolic process (GO:0046037)3.19341629
62cellular component biogenesis (GO:0044085)3.18574765
63mitotic sister chromatid segregation (GO:0000070)3.18465165
64rRNA processing (GO:0006364)3.18370963
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17970771
66somatic hypermutation of immunoglobulin genes (GO:0016446)3.17970771
67DNA replication-independent nucleosome assembly (GO:0006336)3.15976751
68DNA replication-independent nucleosome organization (GO:0034724)3.15976751
69spliceosomal snRNP assembly (GO:0000387)3.12815115
70establishment of chromosome localization (GO:0051303)3.12386639
71oxidative phosphorylation (GO:0006119)3.11896706
72kinetochore organization (GO:0051383)3.08224637
73establishment of viral latency (GO:0019043)3.07217373
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.07081453
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06948512
76rRNA metabolic process (GO:0016072)3.06333717
77attachment of spindle microtubules to kinetochore (GO:0008608)3.06166902
78cellular protein complex disassembly (GO:0043624)3.04931349
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04534117
80establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04107978
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03262951
82protein deneddylation (GO:0000338)3.02510379
83base-excision repair (GO:0006284)3.01630204
84establishment of protein localization to membrane (GO:0090150)3.01576175
85negative regulation of RNA splicing (GO:0033119)3.01291622
86nuclear envelope organization (GO:0006998)3.00734515
87viral life cycle (GO:0019058)3.00497497
88sister chromatid segregation (GO:0000819)3.00356540
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99952156
90protein localization to endoplasmic reticulum (GO:0070972)2.99634834
91positive regulation of chromosome segregation (GO:0051984)2.98425326
92* ribonucleoprotein complex assembly (GO:0022618)2.94147491
93pore complex assembly (GO:0046931)2.93570310
94G1/S transition of mitotic cell cycle (GO:0000082)2.91347835
95cell cycle G1/S phase transition (GO:0044843)2.91347835
96establishment of protein localization to organelle (GO:0072594)2.90533077
97energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89985564
98ATP synthesis coupled proton transport (GO:0015986)2.89985564
99protein targeting (GO:0006605)2.88317019
100DNA topological change (GO:0006265)2.87538744
101DNA deamination (GO:0045006)2.87226603
102transcription-coupled nucleotide-excision repair (GO:0006283)2.86987629
103folic acid metabolic process (GO:0046655)2.86904259
104DNA catabolic process, exonucleolytic (GO:0000738)2.86845272
105establishment of protein localization to mitochondrial membrane (GO:0090151)2.85470538
106regulation of translational fidelity (GO:0006450)2.83436480
107translation (GO:0006412)2.83360153
108protein complex disassembly (GO:0043241)2.82697612
109negative regulation of chromosome segregation (GO:0051985)2.82525508
110tRNA aminoacylation (GO:0043039)2.82483314
111amino acid activation (GO:0043038)2.82483314
112negative regulation of ligase activity (GO:0051352)2.81763274
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81763274
114DNA damage response, detection of DNA damage (GO:0042769)2.81428214
115* ribonucleoprotein complex subunit organization (GO:0071826)2.80877422
116spindle checkpoint (GO:0031577)2.80331748
117histone exchange (GO:0043486)2.79916210
118pseudouridine synthesis (GO:0001522)2.79497785
119telomere organization (GO:0032200)2.79333778
120telomere maintenance (GO:0000723)2.79316246
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79129732
122negative regulation of sister chromatid segregation (GO:0033046)2.79129732
123negative regulation of mitotic sister chromatid separation (GO:2000816)2.79129732
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79129732
125regulation of chromosome segregation (GO:0051983)2.78759274
126regulation of mitotic spindle organization (GO:0060236)2.78383583
127tRNA aminoacylation for protein translation (GO:0006418)2.78363879
128synapsis (GO:0007129)2.78323493
129RNA splicing, via transesterification reactions (GO:0000375)2.78110436
130regulation of posttranscriptional gene silencing (GO:0060147)2.78050035
131regulation of gene silencing by miRNA (GO:0060964)2.78050035
132regulation of gene silencing by RNA (GO:0060966)2.78050035
133rRNA modification (GO:0000154)2.74365834
134regulation of helicase activity (GO:0051095)2.73175986
135* regulation of translational initiation (GO:0006446)2.70159415
136negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66576784
137ncRNA 3-end processing (GO:0043628)2.65198051
138histone H2A acetylation (GO:0043968)2.63729313
139resolution of meiotic recombination intermediates (GO:0000712)2.63171416
140mitotic sister chromatid cohesion (GO:0007064)2.63107898
141mismatch repair (GO:0006298)2.61195053
142regulation of mitochondrial translation (GO:0070129)2.60164831
143gene expression (GO:0010467)2.59376049
144aerobic respiration (GO:0009060)2.58415347
145negative regulation of mRNA processing (GO:0050686)2.55258228
146tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53940376
147RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53940376
148negative regulation of translational initiation (GO:0045947)2.53284585
149DNA double-strand break processing (GO:0000729)2.51890284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.16155863
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.31712565
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85217777
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.72556491
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37178535
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06107240
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90724187
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89863918
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.81899963
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81027140
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76662325
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.64648187
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.61446984
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56613782
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52208123
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41269746
17XRN2_22483619_ChIP-Seq_HELA_Human2.32983360
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26311424
19AR_21909140_ChIP-Seq_LNCAP_Human2.21725478
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18434028
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.07916643
22VDR_23849224_ChIP-Seq_CD4+_Human2.04015032
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03147678
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01127655
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99090351
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94945271
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91472606
28DCP1A_22483619_ChIP-Seq_HELA_Human1.91341905
29FOXP3_21729870_ChIP-Seq_TREG_Human1.87354368
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.86766552
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82046699
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77082008
33GABP_19822575_ChIP-Seq_HepG2_Human1.76571526
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73587396
35TTF2_22483619_ChIP-Seq_HELA_Human1.71986473
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68943787
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68759544
38MYC_22102868_ChIP-Seq_BL_Human1.68707289
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67901655
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60019033
41* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58954108
42CIITA_25753668_ChIP-Seq_RAJI_Human1.57753633
43ELK1_19687146_ChIP-ChIP_HELA_Human1.56295681
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56281937
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53779506
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53598763
47MYC_18940864_ChIP-ChIP_HL60_Human1.52568003
48IGF1R_20145208_ChIP-Seq_DFB_Human1.52232813
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51636341
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50650040
51* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49741361
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.44535205
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43350671
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.42525908
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.42495593
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41541501
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.40929530
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40274461
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37787667
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37567904
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33367730
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.24583113
63TFEB_21752829_ChIP-Seq_HELA_Human1.24298866
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23959997
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22572514
66IRF1_19129219_ChIP-ChIP_H3396_Human1.22480981
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22083721
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21621424
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20179504
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19087286
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17848340
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17309780
73ZNF274_21170338_ChIP-Seq_K562_Hela1.17106823
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15510939
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.13744886
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12777879
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11921483
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10952725
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10819768
80FUS_26573619_Chip-Seq_HEK293_Human1.09819780
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08789563
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08151833
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07984276
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07984276
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07984276
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06846026
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06112513
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05197332
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04435630
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02458301
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99210144
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99133520
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98929411
94VDR_21846776_ChIP-Seq_THP-1_Human0.98453948
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98115002
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95556650
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95096182
98EWS_26573619_Chip-Seq_HEK293_Human0.94336963
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94223411
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94186658
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93204492
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93007300
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92260861
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90426517
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.89573730
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.89407453
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87943987
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87352282
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86432283
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85925069
111* ELK1_22589737_ChIP-Seq_MCF10A_Human0.85783806
112ZNF263_19887448_ChIP-Seq_K562_Human0.84901651
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83642126
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83168641
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.83122504
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81645316
117SPI1_23547873_ChIP-Seq_NB4_Human0.81205429
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80973259
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80727806
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.80057627
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77777456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.76183278
2MP0004957_abnormal_blastocyst_morpholog4.25868339
3MP0010094_abnormal_chromosome_stability4.08371156
4MP0003111_abnormal_nucleus_morphology4.01132791
5MP0009379_abnormal_foot_pigmentation3.81709655
6MP0003077_abnormal_cell_cycle3.75503061
7MP0008057_abnormal_DNA_replication3.61249464
8MP0010352_gastrointestinal_tract_polyps3.17449188
9MP0006292_abnormal_olfactory_placode2.91034887
10MP0008007_abnormal_cellular_replicative2.82871237
11MP0008058_abnormal_DNA_repair2.81735046
12MP0008932_abnormal_embryonic_tissue2.50317226
13MP0001730_embryonic_growth_arrest2.47975286
14MP0008789_abnormal_olfactory_epithelium2.46639280
15MP0003123_paternal_imprinting2.36549620
16MP0008995_early_reproductive_senescence2.29856726
17MP0005499_abnormal_olfactory_system2.22530096
18MP0005394_taste/olfaction_phenotype2.22530096
19MP0000350_abnormal_cell_proliferation2.18172341
20MP0003806_abnormal_nucleotide_metabolis2.18127205
21MP0002396_abnormal_hematopoietic_system2.18126155
22MP0010307_abnormal_tumor_latency2.06990011
23MP0002938_white_spotting1.96616722
24MP0002009_preneoplasia1.92865502
25MP0003122_maternal_imprinting1.92804923
26MP0002102_abnormal_ear_morphology1.91048868
27MP0001529_abnormal_vocalization1.88097998
28MP0009697_abnormal_copulation1.79028214
29MP0003786_premature_aging1.77040119
30MP0001672_abnormal_embryogenesis/_devel1.73040514
31MP0005380_embryogenesis_phenotype1.73040514
32MP0006035_abnormal_mitochondrial_morpho1.72931079
33MP0004147_increased_porphyrin_level1.71579139
34MP0003705_abnormal_hypodermis_morpholog1.71396808
35MP0001697_abnormal_embryo_size1.69981375
36MP0005075_abnormal_melanosome_morpholog1.67928705
37MP0000566_synostosis1.65865403
38MP0002080_prenatal_lethality1.62062846
39MP0003984_embryonic_growth_retardation1.60978299
40MP0000490_abnormal_crypts_of1.60189567
41MP0006054_spinal_hemorrhage1.60141138
42MP0002088_abnormal_embryonic_growth/wei1.57136275
43MP0004197_abnormal_fetal_growth/weight/1.53384056
44MP0003567_abnormal_fetal_cardiomyocyte1.50606022
45MP0002085_abnormal_embryonic_tissue1.47057924
46MP0000537_abnormal_urethra_morphology1.43901217
47MP0002084_abnormal_developmental_patter1.42800245
48MP0002086_abnormal_extraembryonic_tissu1.42523721
49MP0002019_abnormal_tumor_incidence1.39831012
50MP0010030_abnormal_orbit_morphology1.38717744
51MP0002233_abnormal_nose_morphology1.38350505
52MP0002234_abnormal_pharynx_morphology1.37970946
53MP0000313_abnormal_cell_death1.33209946
54MP0008877_abnormal_DNA_methylation1.29925586
55MP0004808_abnormal_hematopoietic_stem1.29334534
56MP0000372_irregular_coat_pigmentation1.29063076
57MP0005023_abnormal_wound_healing1.27973865
58MP0000049_abnormal_middle_ear1.27680870
59MP0005076_abnormal_cell_differentiation1.27268965
60MP0009053_abnormal_anal_canal1.24296510
61MP0006036_abnormal_mitochondrial_physio1.22394970
62MP0009333_abnormal_splenocyte_physiolog1.20526534
63MP0003566_abnormal_cell_adhesion1.16763184
64MP0002697_abnormal_eye_size1.15533937
65MP0008438_abnormal_cutaneous_collagen1.14661607
66MP0003136_yellow_coat_color1.12714185
67MP0001293_anophthalmia1.12284469
68MP0001545_abnormal_hematopoietic_system1.11651864
69MP0005397_hematopoietic_system_phenotyp1.11651864
70MP0006072_abnormal_retinal_apoptosis1.11126073
71MP0003718_maternal_effect1.08234179
72MP0003938_abnormal_ear_development1.06964552
73MP0003186_abnormal_redox_activity1.06954206
74MP0000631_abnormal_neuroendocrine_gland1.01193359
75MP0000858_altered_metastatic_potential1.00296762
76MP0003763_abnormal_thymus_physiology0.99768763
77MP0002653_abnormal_ependyma_morphology0.99161102
78MP0000358_abnormal_cell_content/0.97816299
79MP0000703_abnormal_thymus_morphology0.96291286
80MP0003861_abnormal_nervous_system0.95946135
81MP0003890_abnormal_embryonic-extraembry0.94793850
82MP0003943_abnormal_hepatobiliary_system0.94285223
83MP0003698_abnormal_male_reproductive0.93882375
84MP0003121_genomic_imprinting0.93849183
85MP0002095_abnormal_skin_pigmentation0.93688369
86MP0002751_abnormal_autonomic_nervous0.92502219
87MP0002111_abnormal_tail_morphology0.90226635
88MP0001346_abnormal_lacrimal_gland0.88871654
89MP0001764_abnormal_homeostasis0.88007699
90MP0003221_abnormal_cardiomyocyte_apopto0.86827286
91MP0009672_abnormal_birth_weight0.86204026
92MP0002722_abnormal_immune_system0.85834341
93MP0004133_heterotaxia0.84191088
94MP0003315_abnormal_perineum_morphology0.83728708
95MP0003941_abnormal_skin_development0.83303605
96MP0001849_ear_inflammation0.83164244
97MP0005084_abnormal_gallbladder_morpholo0.82931474
98MP0005391_vision/eye_phenotype0.82053435
99MP0002398_abnormal_bone_marrow0.81704621
100MP0003119_abnormal_digestive_system0.81167269
101MP0002210_abnormal_sex_determination0.80062347
102MP0001915_intracranial_hemorrhage0.79210388
103MP0005384_cellular_phenotype0.78738232
104MP0004264_abnormal_extraembryonic_tissu0.78509565
105MP0000689_abnormal_spleen_morphology0.78108081
106MP0001145_abnormal_male_reproductive0.77693860
107MP0002160_abnormal_reproductive_system0.75481360
108MP0005621_abnormal_cell_physiology0.74606839
109MP0003385_abnormal_body_wall0.73854888
110MP0005501_abnormal_skin_physiology0.72926754
111MP0002163_abnormal_gland_morphology0.72612992
112MP0005275_abnormal_skin_tensile0.72352769
113MP0001243_abnormal_dermal_layer0.71689703
114MP0000477_abnormal_intestine_morphology0.70997812
115MP0010234_abnormal_vibrissa_follicle0.69271609
116MP0000750_abnormal_muscle_regeneration0.69111900
117MP0003755_abnormal_palate_morphology0.68665086
118MP0002429_abnormal_blood_cell0.68257185
119MP0003935_abnormal_craniofacial_develop0.67583664
120MP0003283_abnormal_digestive_organ0.67002479
121MP0002114_abnormal_axial_skeleton0.66743816
122MP0000778_abnormal_nervous_system0.66427916
123MP0002932_abnormal_joint_morphology0.65825435
124MP0002092_abnormal_eye_morphology0.65769041
125MP0001984_abnormal_olfaction0.62949371
126MP0000428_abnormal_craniofacial_morphol0.62117814
127MP0000733_abnormal_muscle_development0.60871704
128MP0009703_decreased_birth_body0.60597175
129MP0001853_heart_inflammation0.60444381
130MP0001324_abnormal_eye_pigmentation0.60307369
131MP0000653_abnormal_sex_gland0.60260968
132MP0002060_abnormal_skin_morphology0.59203273
133MP0002132_abnormal_respiratory_system0.58675899
134MP0005266_abnormal_metabolism0.57817463
135MP0005389_reproductive_system_phenotype0.57666679
136MP0005503_abnormal_tendon_morphology0.56881062
137MP0009278_abnormal_bone_marrow0.55791261
138MP0000598_abnormal_liver_morphology0.54979814
139MP0001119_abnormal_female_reproductive0.54860368
140MP0005367_renal/urinary_system_phenotyp0.54700414
141MP0000516_abnormal_urinary_system0.54700414
142MP0003937_abnormal_limbs/digits/tail_de0.54597523
143MP0003115_abnormal_respiratory_system0.54566332
144MP0003448_altered_tumor_morphology0.54410525
145MP0001286_abnormal_eye_development0.54168871
146MP0001929_abnormal_gametogenesis0.52752330

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.35418473
2Colon cancer (HP:0003003)4.17485542
3Reticulocytopenia (HP:0001896)4.12258971
4Selective tooth agenesis (HP:0001592)3.87763078
5Microvesicular hepatic steatosis (HP:0001414)3.76319880
6Abnormality of cells of the erythroid lineage (HP:0012130)3.75296788
7Breast hypoplasia (HP:0003187)3.51958633
8Abnormal number of erythroid precursors (HP:0012131)3.48261611
9Oral leukoplakia (HP:0002745)3.42162737
10Degeneration of anterior horn cells (HP:0002398)3.40957871
11Abnormality of the anterior horn cell (HP:0006802)3.40957871
12Ependymoma (HP:0002888)3.36360665
13Medulloblastoma (HP:0002885)3.04671340
14Multiple enchondromatosis (HP:0005701)3.01575584
15Agnosia (HP:0010524)2.97773068
16Carpal bone hypoplasia (HP:0001498)2.95977719
17Rough bone trabeculation (HP:0100670)2.92353574
1811 pairs of ribs (HP:0000878)2.84958468
19Trismus (HP:0000211)2.83366737
20Patellar aplasia (HP:0006443)2.82329968
21Depressed nasal ridge (HP:0000457)2.81684754
22Aplastic anemia (HP:0001915)2.78771425
23Triphalangeal thumb (HP:0001199)2.72703180
24Increased hepatocellular lipid droplets (HP:0006565)2.71492618
25Cerebral hypomyelination (HP:0006808)2.71315247
26Chromsome breakage (HP:0040012)2.70899466
27Macrocytic anemia (HP:0001972)2.66708241
28Aplasia/Hypoplasia of the patella (HP:0006498)2.62316689
29Cortical dysplasia (HP:0002539)2.62136537
30Absent thumb (HP:0009777)2.52793787
31Neoplasm of the pancreas (HP:0002894)2.50791503
32Missing ribs (HP:0000921)2.45879731
33Type 2 muscle fiber atrophy (HP:0003554)2.45843601
34Hyperglycinemia (HP:0002154)2.45316072
35Thrombocytosis (HP:0001894)2.45020141
36Stenosis of the external auditory canal (HP:0000402)2.44803691
37Abnormality of the calcaneus (HP:0008364)2.41309169
38Deviation of the thumb (HP:0009603)2.41222388
39Proximal placement of thumb (HP:0009623)2.39250451
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36393677
41Rhabdomyosarcoma (HP:0002859)2.34848585
42Pallor (HP:0000980)2.31099813
43Lipid accumulation in hepatocytes (HP:0006561)2.31070916
44Glossoptosis (HP:0000162)2.29201171
45Abnormality of chromosome stability (HP:0003220)2.27536615
46Premature graying of hair (HP:0002216)2.24093508
47Basal cell carcinoma (HP:0002671)2.21019695
48Abnormality of the preputium (HP:0100587)2.20995644
49Meckel diverticulum (HP:0002245)2.20472191
50High anterior hairline (HP:0009890)2.19066538
51Hepatic necrosis (HP:0002605)2.18838922
52Atresia of the external auditory canal (HP:0000413)2.18110107
53Absent radius (HP:0003974)2.17015456
54Myelodysplasia (HP:0002863)2.16689284
55Abnormal number of incisors (HP:0011064)2.16537162
56Hyperglycinuria (HP:0003108)2.16529547
57Abnormality of the labia minora (HP:0012880)2.16525425
58Cutaneous melanoma (HP:0012056)2.15551217
59Spinal muscular atrophy (HP:0007269)2.12537985
60Muscle fiber atrophy (HP:0100295)2.12210136
61Abnormality of the ileum (HP:0001549)2.11947062
62Squamous cell carcinoma (HP:0002860)2.10102647
63Microretrognathia (HP:0000308)2.10004655
64Acute necrotizing encephalopathy (HP:0006965)2.09891286
65Angiofibromas (HP:0010615)2.09303176
66Adenoma sebaceum (HP:0009720)2.09303176
67Shoulder girdle muscle weakness (HP:0003547)2.08900506
68Optic nerve coloboma (HP:0000588)2.08438709
69Impulsivity (HP:0100710)2.07362152
70Astrocytoma (HP:0009592)2.06757043
71Abnormality of the astrocytes (HP:0100707)2.06757043
72Abnormal trabecular bone morphology (HP:0100671)2.04843741
73Increased CSF lactate (HP:0002490)2.04545667
74Amaurosis fugax (HP:0100576)2.03755708
75Secondary amenorrhea (HP:0000869)2.03195811
76Hepatocellular necrosis (HP:0001404)2.02893071
77Neoplasm of the colon (HP:0100273)2.02525909
78Acute encephalopathy (HP:0006846)2.00344871
79Abnormality of the metopic suture (HP:0005556)1.99382601
80Nephroblastoma (Wilms tumor) (HP:0002667)1.98660341
81Absent forearm bone (HP:0003953)1.98235441
82Aplasia involving forearm bones (HP:0009822)1.98235441
83Abnormality of serine family amino acid metabolism (HP:0010894)1.97829777
84Abnormality of glycine metabolism (HP:0010895)1.97829777
85Supernumerary spleens (HP:0009799)1.97675707
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.97287452
87Ovarian neoplasm (HP:0100615)1.96604030
88Premature ovarian failure (HP:0008209)1.96503835
89Cellular immunodeficiency (HP:0005374)1.96172471
90Increased serum lactate (HP:0002151)1.96140039
91Small intestinal stenosis (HP:0012848)1.95518949
92Duodenal stenosis (HP:0100867)1.95518949
93Rimmed vacuoles (HP:0003805)1.94915068
94Abnormality of glycolysis (HP:0004366)1.94556334
95Slender long bone (HP:0003100)1.94272782
96Abnormality of the umbilical cord (HP:0010881)1.94010197
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93842860
98Short 4th metacarpal (HP:0010044)1.93842860
99Bone marrow hypocellularity (HP:0005528)1.93471918
100Aplasia/hypoplasia of the humerus (HP:0006507)1.93150609
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.92564182
102Abnormality of pyrimidine metabolism (HP:0004353)1.92256941
103Abnormal lung lobation (HP:0002101)1.91505553
104Abnormality of DNA repair (HP:0003254)1.90141173
105Glioma (HP:0009733)1.90136959
106Abnormality of the duodenum (HP:0002246)1.90105613
107Increased nuchal translucency (HP:0010880)1.89928288
108Atrophy/Degeneration involving motor neurons (HP:0007373)1.89525932
109Lactic acidosis (HP:0003128)1.89027602
110Sloping forehead (HP:0000340)1.88795551
111Congenital primary aphakia (HP:0007707)1.88385459
112CNS hypomyelination (HP:0003429)1.88111674
113Mitochondrial inheritance (HP:0001427)1.87895285
114Ankle contracture (HP:0006466)1.87821940
115Bile duct proliferation (HP:0001408)1.87469385
116Abnormal biliary tract physiology (HP:0012439)1.87469385
117Prominent metopic ridge (HP:0005487)1.86618718
118Nephrogenic diabetes insipidus (HP:0009806)1.86211356
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85953998
120Tracheoesophageal fistula (HP:0002575)1.85260532
121Medial flaring of the eyebrow (HP:0010747)1.85154486
122Abnormal mitochondria in muscle tissue (HP:0008316)1.84633616
123Bilateral microphthalmos (HP:0007633)1.84420726
124Spastic diplegia (HP:0001264)1.84233012
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84176042
126Irregular epiphyses (HP:0010582)1.84175903
127Panhypogammaglobulinemia (HP:0003139)1.83372297
128Asplenia (HP:0001746)1.83163497
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83124956
130Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83124956
131Respiratory difficulties (HP:0002880)1.80951228
132Biliary tract neoplasm (HP:0100574)1.79856264
133Metaphyseal cupping (HP:0003021)1.78756967
134Abnormality of reticulocytes (HP:0004312)1.78533778
135Increased serum pyruvate (HP:0003542)1.77891406
136Exercise-induced muscle cramps (HP:0003710)1.77080309
137Megaloblastic anemia (HP:0001889)1.76568322
138Embryonal renal neoplasm (HP:0011794)1.74937170
139Intestinal atresia (HP:0011100)1.74075269
140Ureteral duplication (HP:0000073)1.73698414
141Calcaneovalgus deformity (HP:0001848)1.73165582
142Protrusio acetabuli (HP:0003179)1.72085743
143Horseshoe kidney (HP:0000085)1.72043451
144Volvulus (HP:0002580)1.71955615
145Thick lower lip vermilion (HP:0000179)1.71624598
146Progressive macrocephaly (HP:0004481)1.71127633
147Hypoplastic pelvis (HP:0008839)1.70144866
148Neoplasm of the oral cavity (HP:0100649)1.70063799
149Cerebral edema (HP:0002181)1.69655537
150Ectopic kidney (HP:0000086)1.68932295
151Abnormal umbilical cord blood vessels (HP:0011403)1.68527275
152Single umbilical artery (HP:0001195)1.68527275
153Abnormality of the fetal cardiovascular system (HP:0010948)1.68527275
154Neoplasm of striated muscle (HP:0009728)1.68257799
155High pitched voice (HP:0001620)1.68204750
156Progressive external ophthalmoplegia (HP:0000590)1.68004309
157Broad foot (HP:0001769)1.67850877
158Pancreatic islet-cell hyperplasia (HP:0004510)1.67201867
159Intestinal polyp (HP:0005266)1.66986529
160Gait imbalance (HP:0002141)1.66946308
161Hyperinsulinemic hypoglycemia (HP:0000825)1.65382089
162IgM deficiency (HP:0002850)1.63912966
163Morphological abnormality of the inner ear (HP:0011390)1.60720577
164Acute lymphatic leukemia (HP:0006721)1.60332399
165Broad distal phalanx of finger (HP:0009836)1.60218358
166Myoglobinuria (HP:0002913)1.59518204
167Genital tract atresia (HP:0001827)1.56815421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.67221598
2BUB14.38535594
3WEE13.97958182
4CDC73.64422606
5EIF2AK13.12403223
6VRK23.00122229
7TSSK62.96203774
8NEK12.36919650
9NEK22.35744256
10PASK2.23415789
11MAP4K22.11396930
12NME22.08498485
13TTK2.08084600
14EEF2K2.03917279
15BRSK22.02397791
16EIF2AK31.98877101
17TESK21.95428348
18RPS6KB21.93050913
19SRPK11.84426111
20PLK11.78367523
21ACVR1B1.78111895
22EPHA21.75950971
23CDK71.64913913
24TAF11.63434780
25AURKB1.63345681
26TGFBR11.61530210
27SCYL21.61378925
28PLK31.58732120
29ATR1.58258572
30MKNK11.51349847
31VRK11.45640482
32PKN21.45609044
33NUAK11.45178528
34RPS6KA41.45092087
35STK161.42844137
36MAP3K81.42135652
37PAK41.41560137
38CDK121.39055913
39PLK41.38794800
40STK101.37706959
41TRIM281.32980170
42FLT31.23699362
43DYRK21.22730761
44BCKDK1.20042409
45TESK11.19552265
46BRSK11.19014789
47MAP3K41.18434308
48TLK11.18093906
49CDK41.16005252
50DYRK31.13695726
51LRRK21.13667482
52AURKA1.11207006
53MAP3K101.10827327
54CHEK11.08992744
55CHEK21.08623776
56DYRK1B1.03687622
57ERBB30.99554130
58ZAK0.98608726
59STK40.97794286
60SMG10.93739409
61CCNB10.87564649
62MAP4K10.84930314
63NME10.84724933
64PIM10.84336185
65CSNK1G30.84144296
66PIM20.83762015
67TRIB30.83016913
68TIE10.82550843
69ALK0.80268293
70PNCK0.77714749
71CSNK1G10.77416018
72MAP2K30.77314420
73PAK10.75272875
74ATM0.74308525
75CDK20.74124016
76KDR0.72657909
77BCR0.71795755
78FGFR20.69994842
79TTN0.68677714
80CDK30.68217204
81CSNK2A20.68074524
82PDK30.67454456
83PDK40.67454456
84CDK60.67310995
85MAPKAPK30.66852929
86WNK30.62565235
87MKNK20.62209261
88KIT0.60223511
89CSNK1G20.59740843
90CSNK2A10.59685847
91PRKCI0.59496725
92ILK0.58052487
93LIMK10.56706785
94ZAP700.55044834
95MTOR0.54906845
96STK38L0.54227724
97STK30.54006464
98PAK20.53672979
99CDK10.52302568
100CDK11A0.51468829
101EIF2AK20.51159065
102MELK0.49365225
103CSNK1A1L0.46917817
104RPS6KB10.46301188
105DAPK10.45375794
106TAOK20.45142443
107MAP3K30.44903623
108BTK0.43013337
109BRD40.42644909
110NLK0.41773878
111FGFR10.40075501
112AKT20.38906255
113PDK20.38125679
114CDK90.37862628
115MATK0.37672056
116MST40.36859338
117ERN10.36628806
118MAP2K40.36537174
119CDK140.36100435
120RPS6KA50.35479445
121EPHA40.32496902
122CDK80.31946521
123NEK90.31593390
124MET0.30974419
125MAP3K110.30786981
126TNIK0.30577152
127DYRK1A0.30090706
128PBK0.30083863
129CLK10.29993905
130MAP3K60.29740990
131CDK150.28940931
132CSNK1E0.28853590
133MAP2K70.28558078
134LATS10.28230599
135CDK180.28218980
136BMPR1B0.27131011
137JAK30.27002853
138RPS6KA10.26935218
139PRKDC0.26636343
140LATS20.25829194

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72010434
2Mismatch repair_Homo sapiens_hsa034304.04515585
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50868066
4Ribosome_Homo sapiens_hsa030103.35974451
5Proteasome_Homo sapiens_hsa030503.34193960
6RNA transport_Homo sapiens_hsa030133.13352572
7Spliceosome_Homo sapiens_hsa030403.10954196
8Base excision repair_Homo sapiens_hsa034102.94973972
9One carbon pool by folate_Homo sapiens_hsa006702.91752651
10RNA polymerase_Homo sapiens_hsa030202.88254535
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.82829555
12Nucleotide excision repair_Homo sapiens_hsa034202.75915499
13Homologous recombination_Homo sapiens_hsa034402.53033943
14Cell cycle_Homo sapiens_hsa041102.51955276
15Pyrimidine metabolism_Homo sapiens_hsa002402.30906451
16Non-homologous end-joining_Homo sapiens_hsa034501.89883783
17Oxidative phosphorylation_Homo sapiens_hsa001901.80789218
18Fanconi anemia pathway_Homo sapiens_hsa034601.69032301
19Propanoate metabolism_Homo sapiens_hsa006401.68960686
20RNA degradation_Homo sapiens_hsa030181.67412504
21p53 signaling pathway_Homo sapiens_hsa041151.56943332
22Fatty acid elongation_Homo sapiens_hsa000621.54454933
23mRNA surveillance pathway_Homo sapiens_hsa030151.51142636
24Basal transcription factors_Homo sapiens_hsa030221.49061832
25Biosynthesis of amino acids_Homo sapiens_hsa012301.32505308
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27318386
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25251582
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22605612
29Systemic lupus erythematosus_Homo sapiens_hsa053221.18487455
30Epstein-Barr virus infection_Homo sapiens_hsa051691.17771657
31Purine metabolism_Homo sapiens_hsa002301.15992837
32Selenocompound metabolism_Homo sapiens_hsa004501.13895273
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12529272
34Pentose phosphate pathway_Homo sapiens_hsa000301.11242857
35Viral carcinogenesis_Homo sapiens_hsa052031.03248110
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.02597253
37Carbon metabolism_Homo sapiens_hsa012001.00953027
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.00701003
39Antigen processing and presentation_Homo sapiens_hsa046120.99606246
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94557199
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89354394
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.87961577
43Folate biosynthesis_Homo sapiens_hsa007900.86722549
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84929884
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80514667
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77755860
47Legionellosis_Homo sapiens_hsa051340.76990674
48Herpes simplex infection_Homo sapiens_hsa051680.75957677
49Protein export_Homo sapiens_hsa030600.74502720
50Alzheimers disease_Homo sapiens_hsa050100.73984152
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73309197
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72480652
53HTLV-I infection_Homo sapiens_hsa051660.71524284
54Glutathione metabolism_Homo sapiens_hsa004800.70778892
55Vitamin B6 metabolism_Homo sapiens_hsa007500.70415217
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70205601
57Small cell lung cancer_Homo sapiens_hsa052220.66549577
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66055681
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66021445
60Oocyte meiosis_Homo sapiens_hsa041140.64354376
61Regulation of autophagy_Homo sapiens_hsa041400.62065758
62Thyroid cancer_Homo sapiens_hsa052160.61475800
63Steroid biosynthesis_Homo sapiens_hsa001000.60882129
64Butanoate metabolism_Homo sapiens_hsa006500.60638739
65N-Glycan biosynthesis_Homo sapiens_hsa005100.59073081
66Fructose and mannose metabolism_Homo sapiens_hsa000510.57223786
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56679396
68MicroRNAs in cancer_Homo sapiens_hsa052060.54166081
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53692156
70Sulfur relay system_Homo sapiens_hsa041220.50564512
71Peroxisome_Homo sapiens_hsa041460.48124389
72Apoptosis_Homo sapiens_hsa042100.47362217
73Hippo signaling pathway_Homo sapiens_hsa043900.42314742
74Galactose metabolism_Homo sapiens_hsa000520.42197817
75Fatty acid metabolism_Homo sapiens_hsa012120.41264959
76Caffeine metabolism_Homo sapiens_hsa002320.40183938
77TGF-beta signaling pathway_Homo sapiens_hsa043500.38210336
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37557199
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.37344595
80Primary immunodeficiency_Homo sapiens_hsa053400.36909584
81Viral myocarditis_Homo sapiens_hsa054160.36717814
82Bladder cancer_Homo sapiens_hsa052190.36679373
83Shigellosis_Homo sapiens_hsa051310.36364035
84Basal cell carcinoma_Homo sapiens_hsa052170.35695445
85Cardiac muscle contraction_Homo sapiens_hsa042600.35650150
86Pyruvate metabolism_Homo sapiens_hsa006200.34874169
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33573903
88Renin-angiotensin system_Homo sapiens_hsa046140.32780626
89Wnt signaling pathway_Homo sapiens_hsa043100.32193459
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31680296
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31077164
92Notch signaling pathway_Homo sapiens_hsa043300.28761565
93Colorectal cancer_Homo sapiens_hsa052100.28741391
94Chronic myeloid leukemia_Homo sapiens_hsa052200.28115139
95HIF-1 signaling pathway_Homo sapiens_hsa040660.28060217
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27710242
97Measles_Homo sapiens_hsa051620.26968878
98Huntingtons disease_Homo sapiens_hsa050160.26902179
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26879691
100Adherens junction_Homo sapiens_hsa045200.26665346
101Alcoholism_Homo sapiens_hsa050340.25290657
102Hepatitis B_Homo sapiens_hsa051610.23598859
103Metabolic pathways_Homo sapiens_hsa011000.23227318
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22376296
105Pathways in cancer_Homo sapiens_hsa052000.19078150
106Asthma_Homo sapiens_hsa053100.17844884
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17485987
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.17042215
109Arginine and proline metabolism_Homo sapiens_hsa003300.16554864
110Influenza A_Homo sapiens_hsa051640.15595007
111Hedgehog signaling pathway_Homo sapiens_hsa043400.14000706
112Lysine degradation_Homo sapiens_hsa003100.12974033
113Fat digestion and absorption_Homo sapiens_hsa049750.12367060
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12019544
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.11458916
116Acute myeloid leukemia_Homo sapiens_hsa052210.11263287
117Parkinsons disease_Homo sapiens_hsa050120.11127370
118mTOR signaling pathway_Homo sapiens_hsa041500.10801194
119Fatty acid degradation_Homo sapiens_hsa000710.10704366
120Prostate cancer_Homo sapiens_hsa052150.10567480
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10315387
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04161048
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03838025
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.03336717
125beta-Alanine metabolism_Homo sapiens_hsa004100.01096769
126Tryptophan metabolism_Homo sapiens_hsa00380-0.0026994

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