EIF3KP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1growth hormone secretion (GO:0030252)9.64380109
2negative regulation of interleukin-1 beta production (GO:0032691)9.03562686
3adult feeding behavior (GO:0008343)9.00359546
4positive regulation of sodium ion transmembrane transport (GO:1902307)7.63631145
5negative regulation of interleukin-1 production (GO:0032692)7.59012661
6regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)7.46091780
7positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)6.79374637
8regulation of response to food (GO:0032095)6.69770076
9response to food (GO:0032094)5.67770113
10one-carbon compound transport (GO:0019755)5.65131108
11regulation of appetite (GO:0032098)5.54246110
12regulation of interleukin-6 biosynthetic process (GO:0045408)5.44612704
13hindbrain development (GO:0030902)5.26417460
14protein import into peroxisome matrix (GO:0016558)4.96223369
15negative regulation of peptidyl-serine phosphorylation (GO:0033137)4.92338637
16striated muscle atrophy (GO:0014891)4.82160294
17auditory receptor cell stereocilium organization (GO:0060088)4.68244113
18regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.62264477
19sperm capacitation (GO:0048240)4.39403482
20regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.38031079
21adaptation of signaling pathway (GO:0023058)4.33764470
22regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.24977802
23water-soluble vitamin biosynthetic process (GO:0042364)4.21132535
24muscle atrophy (GO:0014889)4.16887892
25behavioral response to nicotine (GO:0035095)4.12009145
26cell morphogenesis involved in neuron differentiation (GO:0048667)4.01863961
27skeletal muscle adaptation (GO:0043501)4.00383057
28positive regulation of gluconeogenesis (GO:0045722)3.95344276
29multicellular organism reproduction (GO:0032504)3.87808100
30positive thymic T cell selection (GO:0045059)3.87246184
31spinal cord development (GO:0021510)3.76956662
32positive regulation of sodium ion transport (GO:0010765)3.76622607
33protein kinase B signaling (GO:0043491)3.73475979
34inner ear receptor stereocilium organization (GO:0060122)3.63514133
35NAD biosynthetic process (GO:0009435)3.62034892
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.60082780
37ATP hydrolysis coupled proton transport (GO:0015991)3.50539816
38energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.50539816
39cysteine metabolic process (GO:0006534)3.43308396
40regulation of sodium ion transmembrane transporter activity (GO:2000649)3.41036630
41decidualization (GO:0046697)3.37522981
42cornea development in camera-type eye (GO:0061303)3.37397094
43protein targeting to peroxisome (GO:0006625)3.35722251
44establishment of protein localization to peroxisome (GO:0072663)3.35722251
45protein localization to peroxisome (GO:0072662)3.35722251
46cellular response to pH (GO:0071467)3.27791724
47nephron tubule morphogenesis (GO:0072078)3.26307571
48nephron epithelium morphogenesis (GO:0072088)3.26307571
49regulation of mitochondrial membrane permeability (GO:0046902)3.23191186
502-oxoglutarate metabolic process (GO:0006103)3.22671980
51ovulation cycle (GO:0042698)3.21787185
52mannosylation (GO:0097502)3.21455365
53regulation of membrane permeability (GO:0090559)3.19981502
54male sex determination (GO:0030238)3.19025616
55positive regulation of fatty acid metabolic process (GO:0045923)3.18291774
56negative regulation of ERK1 and ERK2 cascade (GO:0070373)3.17890370
57urate metabolic process (GO:0046415)3.16959954
58ubiquinone biosynthetic process (GO:0006744)3.14923921
59protein refolding (GO:0042026)3.14727033
60UDP-N-acetylglucosamine metabolic process (GO:0006047)3.11019852
61intracellular protein transmembrane import (GO:0044743)3.10874071
62indolalkylamine metabolic process (GO:0006586)3.02953210
63positive T cell selection (GO:0043368)3.02287390
64negative regulation of systemic arterial blood pressure (GO:0003085)3.02086225
65regulation of male gonad development (GO:2000018)3.01439102
66neuronal action potential (GO:0019228)2.95388372
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95175101
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95175101
69peroxisomal transport (GO:0043574)2.94811022
70regulation of cilium movement (GO:0003352)2.94059271
71regulation of interleukin-1 beta production (GO:0032651)2.93758129
72telencephalon development (GO:0021537)2.93536353
73transcription elongation from RNA polymerase III promoter (GO:0006385)2.92342069
74termination of RNA polymerase III transcription (GO:0006386)2.92342069
75sperm motility (GO:0030317)2.91506018
76C4-dicarboxylate transport (GO:0015740)2.89793508
77fusion of sperm to egg plasma membrane (GO:0007342)2.88046218
78regulation of digestive system process (GO:0044058)2.87572504
79organelle membrane fusion (GO:0090174)2.81684985
80negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.78599740
81negative regulation of interleukin-6 production (GO:0032715)2.78375219
82regulation of somitogenesis (GO:0014807)2.75428709
83ubiquinone metabolic process (GO:0006743)2.74550306
84endocrine pancreas development (GO:0031018)2.71440664
85regulation of histone phosphorylation (GO:0033127)2.70517918
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70075208
87axonemal dynein complex assembly (GO:0070286)2.69275514
88negative regulation of inclusion body assembly (GO:0090084)2.67903537
89intracellular protein transmembrane transport (GO:0065002)2.64339789
90regulation of microtubule-based movement (GO:0060632)2.63619624
91pyridine nucleotide biosynthetic process (GO:0019363)2.61596642
92nicotinamide nucleotide biosynthetic process (GO:0019359)2.61596642
93positive regulation of ion transmembrane transporter activity (GO:0032414)2.60741222
94somite development (GO:0061053)2.60109161
95regulation of dopamine secretion (GO:0014059)2.59451054
96artery development (GO:0060840)2.58302016
97renal tubule morphogenesis (GO:0061333)2.57796876
98positive regulation of response to extracellular stimulus (GO:0032106)2.55031787
99positive regulation of response to nutrient levels (GO:0032109)2.55031787
100positive regulation of sodium ion transmembrane transporter activity (GO:2000651)10.3472730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95051762
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.28500191
3ZNF274_21170338_ChIP-Seq_K562_Hela4.52950692
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.26928634
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.96259864
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73250592
7AR_21572438_ChIP-Seq_LNCaP_Human2.83274886
8VDR_22108803_ChIP-Seq_LS180_Human2.76982794
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.47977017
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30150395
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14615492
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09005486
13GBX2_23144817_ChIP-Seq_PC3_Human2.05944092
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01370138
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.00286097
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.94977164
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82030005
18IRF1_19129219_ChIP-ChIP_H3396_Human1.79129176
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71201123
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.68587213
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.67555074
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67139615
23P300_19829295_ChIP-Seq_ESCs_Human1.62593660
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55370212
25MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54045029
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52785753
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49541434
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49539616
29BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.46466547
30ER_23166858_ChIP-Seq_MCF-7_Human1.44193976
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.42333723
32TP53_22573176_ChIP-Seq_HFKS_Human1.40430732
33FUS_26573619_Chip-Seq_HEK293_Human1.34457555
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33871794
35MYC_18940864_ChIP-ChIP_HL60_Human1.31838352
36EWS_26573619_Chip-Seq_HEK293_Human1.31507065
37TAF2_19829295_ChIP-Seq_ESCs_Human1.31198503
38CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27872760
39GATA3_26560356_Chip-Seq_TH2_Human1.25538013
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21322164
41CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.20271361
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.19367237
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18440402
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.17656991
45HOXB7_26014856_ChIP-Seq_BT474_Human1.17353720
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.14634678
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.13849416
48MYC_19829295_ChIP-Seq_ESCs_Human1.13584679
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.12898712
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12898712
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10875110
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09027816
53CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08627452
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08511046
55REST_21632747_ChIP-Seq_MESCs_Mouse1.08088768
56CTCF_20526341_ChIP-Seq_ESCs_Human1.07705037
57RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06234800
58P53_21459846_ChIP-Seq_SAOS-2_Human1.04253734
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.03402516
60RAC3_21632823_ChIP-Seq_H3396_Human1.02907839
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02546221
62VDR_23849224_ChIP-Seq_CD4+_Human1.02526657
63FOXH1_21741376_ChIP-Seq_ESCs_Human1.01634958
64SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01578756
65SMAD3_21741376_ChIP-Seq_HESCs_Human1.01209749
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.01085156
67SOX2_19829295_ChIP-Seq_ESCs_Human0.98683612
68NANOG_19829295_ChIP-Seq_ESCs_Human0.98683612
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97994861
70CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97347385
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96545474
72OCT4_20526341_ChIP-Seq_ESCs_Human0.95935630
73STAT3_23295773_ChIP-Seq_U87_Human0.95844583
74AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95611593
75ERA_21632823_ChIP-Seq_H3396_Human0.94862590
76NANOG_20526341_ChIP-Seq_ESCs_Human0.93478984
77FLI1_21867929_ChIP-Seq_TH2_Mouse0.92988699
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91807706
79AR_20517297_ChIP-Seq_VCAP_Human0.91528111
80AR_25329375_ChIP-Seq_VCAP_Human0.91387164
81PHF8_20622854_ChIP-Seq_HELA_Human0.89701029
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89585884
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86700394
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.86363689
85DROSHA_22980978_ChIP-Seq_HELA_Human0.86028990
86PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84100443
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82835059
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.82625908
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81736906
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81670872
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81376228
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.80940047
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.80786906
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80384728
95P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.80167820
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.80144621
97P300_27268052_Chip-Seq_Bcells_Human0.79944756
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.79732247
99CEBPB_22108803_ChIP-Seq_LS180_Human0.79381223
100ELK1_19687146_ChIP-ChIP_HELA_Human0.79013958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.22589312
2MP0008872_abnormal_physiological_respon4.03182894
3MP0003868_abnormal_feces_composition3.76044867
4MP0005220_abnormal_exocrine_pancreas3.65163843
5MP0001984_abnormal_olfaction3.00064912
6MP0002653_abnormal_ependyma_morphology2.85458069
7MP0001986_abnormal_taste_sensitivity2.76420912
8MP0003303_peritoneal_inflammation2.76412131
9MP0009278_abnormal_bone_marrow2.47990396
10MP0003119_abnormal_digestive_system2.45382409
11MP0005499_abnormal_olfactory_system2.36373600
12MP0005394_taste/olfaction_phenotype2.36373600
13MP0004147_increased_porphyrin_level2.32880118
14MP0002736_abnormal_nociception_after2.27923725
15MP0001664_abnormal_digestion2.21926383
16MP0008877_abnormal_DNA_methylation2.13986349
17MP0000538_abnormal_urinary_bladder2.13171379
18MP0001663_abnormal_digestive_system1.96947166
19MP0004130_abnormal_muscle_cell1.93096362
20MP0003646_muscle_fatigue1.91014416
21MP0003880_abnormal_central_pattern1.86432377
22MP0001666_abnormal_nutrient_absorption1.86042721
23MP0005084_abnormal_gallbladder_morpholo1.82008138
24MP0010030_abnormal_orbit_morphology1.74868518
25MP0003638_abnormal_response/metabolism_1.74133204
26MP0002876_abnormal_thyroid_physiology1.74070443
27MP0003959_abnormal_lean_body1.68356655
28MP0002102_abnormal_ear_morphology1.66991288
29MP0001968_abnormal_touch/_nociception1.66192532
30MP0001919_abnormal_reproductive_system1.62157488
31MP0008875_abnormal_xenobiotic_pharmacok1.61305248
32MP0001501_abnormal_sleep_pattern1.61260030
33MP0005551_abnormal_eye_electrophysiolog1.61003507
34MP0003806_abnormal_nucleotide_metabolis1.59835535
35MP0006292_abnormal_olfactory_placode1.58490628
36MP0000427_abnormal_hair_cycle1.51239151
37MP0005448_abnormal_energy_balance1.51200868
38MP0004142_abnormal_muscle_tone1.48510856
39MP0003693_abnormal_embryo_hatching1.48478442
40MP0000383_abnormal_hair_follicle1.48118524
41MP0000470_abnormal_stomach_morphology1.47013799
42MP0005381_digestive/alimentary_phenotyp1.45993569
43MP0002928_abnormal_bile_duct1.43679375
44MP0003283_abnormal_digestive_organ1.43174383
45MP0006072_abnormal_retinal_apoptosis1.42531616
46MP0003195_calcinosis1.40760774
47MP0000015_abnormal_ear_pigmentation1.37658536
48MP0002234_abnormal_pharynx_morphology1.36952232
49MP0002160_abnormal_reproductive_system1.34433954
50MP0001486_abnormal_startle_reflex1.28584853
51MP0003172_abnormal_lysosome_physiology1.20835882
52MP0009046_muscle_twitch1.19358111
53MP0005423_abnormal_somatic_nervous1.18375988
54MP0000566_synostosis1.17237793
55MP0009384_cardiac_valve_regurgitation1.15662791
56MP0002095_abnormal_skin_pigmentation1.15217345
57MP0002272_abnormal_nervous_system1.11204278
58MP0002282_abnormal_trachea_morphology1.11052881
59MP0005076_abnormal_cell_differentiation1.10652815
60MP0003866_abnormal_defecation1.08672495
61MP0003011_delayed_dark_adaptation1.08493717
62MP0009745_abnormal_behavioral_response1.06870348
63MP0003183_abnormal_peptide_metabolism1.06089128
64MP0001502_abnormal_circadian_rhythm1.05089641
65MP0000569_abnormal_digit_pigmentation1.02799102
66MP0005397_hematopoietic_system_phenotyp1.01922732
67MP0001545_abnormal_hematopoietic_system1.01922732
68MP0005389_reproductive_system_phenotype1.00521137
69MP0000631_abnormal_neuroendocrine_gland0.99275548
70MP0005083_abnormal_biliary_tract0.97984603
71MP0009672_abnormal_birth_weight0.96725058
72MP0001529_abnormal_vocalization0.96290432
73MP0002063_abnormal_learning/memory/cond0.94655428
74MP0009053_abnormal_anal_canal0.94187007
75MP0005253_abnormal_eye_physiology0.94059908
76MP0002638_abnormal_pupillary_reflex0.93091348
77MP0002693_abnormal_pancreas_physiology0.92675776
78MP0004215_abnormal_myocardial_fiber0.92293312
79MP0010329_abnormal_lipoprotein_level0.91992015
80MP0002064_seizures0.88747197
81MP0001293_anophthalmia0.88182569
82MP0004924_abnormal_behavior0.85847202
83MP0005386_behavior/neurological_phenoty0.85847202
84MP0003787_abnormal_imprinting0.84838738
85MP0006036_abnormal_mitochondrial_physio0.84022596
86MP0005452_abnormal_adipose_tissue0.83578832
87MP0001177_atelectasis0.82968155
88MP0001440_abnormal_grooming_behavior0.82662472
89MP0002572_abnormal_emotion/affect_behav0.82490427
90MP0002067_abnormal_sensory_capabilities0.81415948
91MP0001905_abnormal_dopamine_level0.78874552
92MP0000026_abnormal_inner_ear0.77812150
93MP0005646_abnormal_pituitary_gland0.76378750
94MP0000579_abnormal_nail_morphology0.73853279
95MP0004133_heterotaxia0.72371264
96MP0002557_abnormal_social/conspecific_i0.70065494
97MP0001944_abnormal_pancreas_morphology0.69665014
98MP0006276_abnormal_autonomic_nervous0.68885860
99MP0002734_abnormal_mechanical_nocicepti0.67925666
100MP0005647_abnormal_sex_gland0.67301793

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)5.85837485
2Birth length less than 3rd percentile (HP:0003561)5.61568481
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.56881441
4Abnormality of alanine metabolism (HP:0010916)5.56881441
5Hyperalaninemia (HP:0003348)5.56881441
6Global brain atrophy (HP:0002283)5.13347363
7Retinal dysplasia (HP:0007973)4.34941702
8Pendular nystagmus (HP:0012043)3.87839104
9Cerebellar dysplasia (HP:0007033)3.74212315
10Neoplasm of head and neck (HP:0012288)3.65013426
11Esophageal neoplasm (HP:0100751)3.65013426
12Breast hypoplasia (HP:0003187)3.56204372
13Pancreatic fibrosis (HP:0100732)3.49201563
14Gastrointestinal infarctions (HP:0005244)3.48098137
15Nasal polyposis (HP:0100582)3.47781253
16Rectal prolapse (HP:0002035)3.44748947
17Chorioretinal atrophy (HP:0000533)3.33806527
18Spastic tetraparesis (HP:0001285)3.28216231
19Prominent supraorbital ridges (HP:0000336)3.13704384
20Pancreatic cysts (HP:0001737)3.12327381
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.02078955
22Absent/shortened dynein arms (HP:0200106)3.02078955
23Abnormality of the nasal mucosa (HP:0000433)2.97497073
24Attenuation of retinal blood vessels (HP:0007843)2.94174676
25Progressive inability to walk (HP:0002505)2.89836705
26Mesangial abnormality (HP:0001966)2.89189027
27Nephronophthisis (HP:0000090)2.88119147
28Gonadal dysgenesis (HP:0000133)2.87855761
29Inability to walk (HP:0002540)2.85525310
30Disproportionate short-trunk short stature (HP:0003521)2.82548518
31Brushfield spots (HP:0001088)2.76949293
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75575995
33Tubular atrophy (HP:0000092)2.74294677
34Hypoplastic labia majora (HP:0000059)2.70999361
35Hyperventilation (HP:0002883)2.70516700
36Abnormality of nail color (HP:0100643)2.65063700
37Long nose (HP:0003189)2.61910509
38Congenital stationary night blindness (HP:0007642)2.61101145
39Patellar aplasia (HP:0006443)2.59654161
40Lissencephaly (HP:0001339)2.57399034
41True hermaphroditism (HP:0010459)2.55837212
42Abnormality of midbrain morphology (HP:0002418)2.51864632
43Molar tooth sign on MRI (HP:0002419)2.51864632
44Atonic seizures (HP:0010819)2.51825285
45Progressive microcephaly (HP:0000253)2.49186729
46Anterior segment dysgenesis (HP:0007700)2.46484946
47Abolished electroretinogram (ERG) (HP:0000550)2.45466203
48Rib fusion (HP:0000902)2.44817168
49Abnormality of the labia majora (HP:0012881)2.43466380
50Abnormal ciliary motility (HP:0012262)2.41970452
51Abnormality of the vertebral endplates (HP:0005106)2.39534254
52Aplasia/Hypoplasia of the patella (HP:0006498)2.39303266
53Ulnar claw (HP:0001178)2.38389761
54Abnormality of the renal cortex (HP:0011035)2.37967044
55Partial agenesis of the corpus callosum (HP:0001338)2.37008444
56Fair hair (HP:0002286)2.34777281
57Abnormality of the renal medulla (HP:0100957)2.29359995
58Metaphyseal dysplasia (HP:0100255)2.26947724
59Optic disc pallor (HP:0000543)2.25613238
60Keratoconus (HP:0000563)2.24327198
61Increased corneal curvature (HP:0100692)2.24327198
62Renal cortical cysts (HP:0000803)2.23100683
63Abnormal respiratory epithelium morphology (HP:0012253)2.22532173
64Abnormal respiratory motile cilium morphology (HP:0005938)2.22532173
65Pachygyria (HP:0001302)2.22491283
66Neonatal onset (HP:0003623)2.19993459
67Biliary tract neoplasm (HP:0100574)2.19161708
68Abnormal biliary tract physiology (HP:0012439)2.16061011
69Bile duct proliferation (HP:0001408)2.16061011
70Generalized aminoaciduria (HP:0002909)2.16041870
71High pitched voice (HP:0001620)2.15096373
72Abnormal respiratory motile cilium physiology (HP:0012261)2.15011609
73Hypochromic anemia (HP:0001931)2.14401205
74Brittle hair (HP:0002299)2.13858564
75Abnormality of the fingertips (HP:0001211)2.13163374
76Abnormality of the wing of the ilium (HP:0011867)2.05947696
77Delayed CNS myelination (HP:0002188)2.05833271
78Bronchomalacia (HP:0002780)2.04847393
79Alkalosis (HP:0001948)2.04503135
80Rhinitis (HP:0012384)2.03556761
81Hypomagnesemia (HP:0002917)2.02549298
82Clumsiness (HP:0002312)2.02272630
83Abnormality of serum amino acid levels (HP:0003112)2.02151142
84Abnormality of macular pigmentation (HP:0008002)2.02025407
85Neoplasm of the rectum (HP:0100743)1.99295702
86Acute encephalopathy (HP:0006846)1.97051051
87Ulnar deviation of the wrist (HP:0003049)1.96092242
88Abnormality of the vitreous humor (HP:0004327)1.94912044
89Abnormal number of erythroid precursors (HP:0012131)1.94576181
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.93604344
91Intellectual disability, progressive (HP:0006887)1.91627564
92Labial hypoplasia (HP:0000066)1.90520818
93Female pseudohermaphroditism (HP:0010458)1.89413859
94Cervical subluxation (HP:0003308)1.87331407
95Hepatic necrosis (HP:0002605)1.86955974
96Medial flaring of the eyebrow (HP:0010747)1.84269268
97CNS demyelination (HP:0007305)1.84003108
98Acute necrotizing encephalopathy (HP:0006965)1.80138468
99Abnormality of cells of the erythroid lineage (HP:0012130)1.79194155
100Hypoplastic female external genitalia (HP:0012815)1.76915896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA2.78542813
2FRK2.64806039
3ERBB42.40701014
4WNK42.17496745
5BMPR1B2.08127688
6CDK82.03737534
7STK392.00747324
8INSRR11.7336712
9MAPKAPK51.99947115
10MAP3K111.79613150
11RPS6KA51.65864352
12BCKDK1.36242057
13CAMKK21.34536486
14PKN11.29867553
15LIMK11.27801018
16RPS6KA21.27507109
17RPS6KA61.26633131
18STK111.23118252
19ADRBK21.16221542
20TSSK61.15984990
21OXSR11.15625010
22GRK11.14413674
23ABL21.13214656
24VRK21.04505557
25RPS6KB11.04131284
26AKT20.98013073
27TAOK30.96530532
28PAK30.91690267
29TGFBR10.90916130
30PRKCZ0.88782810
31NME10.85933984
32RPS6KL10.85642736
33RPS6KC10.85642736
34IKBKB0.80692128
35ADRBK10.79717596
36PIK3CG0.79040027
37CAMKK10.71143027
38KIT0.71023087
39PNCK0.70723644
40TLK10.70536326
41JAK30.70383316
42TIE10.69243618
43PHKG10.68984905
44PHKG20.68984905
45PASK0.68638654
46GRK70.68140619
47PDK20.64412318
48MARK10.61768120
49MAPK110.61266414
50MAP2K60.59658796
51ZAK0.59042462
52NTRK30.57223563
53CDK30.56397756
54VRK10.56149205
55DYRK1B0.54450564
56SRPK10.54395145
57PINK10.54148030
58PLK20.52464996
59BUB10.51289685
60CAMK1D0.49240080
61TNK20.49174320
62PRKCG0.49065114
63TEC0.48188585
64TTK0.48065063
65DAPK20.46823229
66CAMK2A0.46765706
67PRKCA0.46749208
68CHUK0.46409024
69CAMK2G0.46096709
70TYRO30.42912648
71PDGFRB0.41394923
72ITK0.40805849
73AKT30.40793165
74ATR0.40727981
75PRKCE0.40382643
76CAMK1G0.39873470
77CSNK2A10.39405153
78CDK90.39396020
79WNK30.38792487
80MKNK10.37620985
81MAPK120.37016375
82PRKG10.35225386
83MUSK0.35099421
84CAMK10.34957276
85OBSCN0.33670342
86MKNK20.33348565
87MAP4K10.33233744
88ERBB20.32866256
89TRIM280.32672419
90PRKACA0.32177647
91TYK20.31806830
92ATM0.31385968
93PRKCQ0.30666788
94ABL10.28864558
95LCK0.28655859
96PTK2B0.28021327
97PRKDC0.27635544
98JAK20.26089367
99PTK60.25794050
100PRKACB0.24938867

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.97651071
2Butanoate metabolism_Homo sapiens_hsa006504.16208377
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.07099648
4Nitrogen metabolism_Homo sapiens_hsa009103.96407426
5RNA polymerase_Homo sapiens_hsa030203.06047543
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.80238696
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.46556168
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.44381264
9Linoleic acid metabolism_Homo sapiens_hsa005912.39465363
10Homologous recombination_Homo sapiens_hsa034402.30579761
11Selenocompound metabolism_Homo sapiens_hsa004502.28418041
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28051361
13Basal transcription factors_Homo sapiens_hsa030222.22551072
14Ether lipid metabolism_Homo sapiens_hsa005652.21997189
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97318360
16Oxidative phosphorylation_Homo sapiens_hsa001901.95587862
17Caffeine metabolism_Homo sapiens_hsa002321.88507188
18Sulfur relay system_Homo sapiens_hsa041221.74869477
19Collecting duct acid secretion_Homo sapiens_hsa049661.74659409
20Tryptophan metabolism_Homo sapiens_hsa003801.70503859
21Phototransduction_Homo sapiens_hsa047441.62291278
22One carbon pool by folate_Homo sapiens_hsa006701.62050354
23Fanconi anemia pathway_Homo sapiens_hsa034601.56195741
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48606963
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43882543
26Parkinsons disease_Homo sapiens_hsa050121.40763717
27Protein export_Homo sapiens_hsa030601.39818606
28Proteasome_Homo sapiens_hsa030501.34892077
29Nicotine addiction_Homo sapiens_hsa050331.25092723
30Huntingtons disease_Homo sapiens_hsa050161.23367536
31Peroxisome_Homo sapiens_hsa041461.16581731
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09565924
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.03376429
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99785163
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96733797
36Histidine metabolism_Homo sapiens_hsa003400.95776108
37Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92418244
38ABC transporters_Homo sapiens_hsa020100.92210565
39Chemical carcinogenesis_Homo sapiens_hsa052040.88611407
40Ribosome_Homo sapiens_hsa030100.83249238
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80655909
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78032332
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.77714816
44Olfactory transduction_Homo sapiens_hsa047400.76303125
45Purine metabolism_Homo sapiens_hsa002300.72621118
46Taste transduction_Homo sapiens_hsa047420.72594774
47Fat digestion and absorption_Homo sapiens_hsa049750.72267462
48Insulin secretion_Homo sapiens_hsa049110.71948325
49Arachidonic acid metabolism_Homo sapiens_hsa005900.69271927
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68900935
51Alzheimers disease_Homo sapiens_hsa050100.68673023
52Pyrimidine metabolism_Homo sapiens_hsa002400.68601204
53Metabolic pathways_Homo sapiens_hsa011000.67309509
54Retinol metabolism_Homo sapiens_hsa008300.67067903
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.65948882
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63492403
57Arginine and proline metabolism_Homo sapiens_hsa003300.63404066
58Cardiac muscle contraction_Homo sapiens_hsa042600.63067957
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62559517
60Nucleotide excision repair_Homo sapiens_hsa034200.61321460
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60207045
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56850114
63Glycerolipid metabolism_Homo sapiens_hsa005610.55132519
64Thyroid hormone synthesis_Homo sapiens_hsa049180.54573875
65Calcium signaling pathway_Homo sapiens_hsa040200.53029411
66Basal cell carcinoma_Homo sapiens_hsa052170.50533730
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48528108
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48396433
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.45816120
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44775776
71cAMP signaling pathway_Homo sapiens_hsa040240.44283250
72Cocaine addiction_Homo sapiens_hsa050300.43404630
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.42238037
74Antigen processing and presentation_Homo sapiens_hsa046120.40905494
75Asthma_Homo sapiens_hsa053100.38415634
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38030369
77beta-Alanine metabolism_Homo sapiens_hsa004100.37787552
78Pyruvate metabolism_Homo sapiens_hsa006200.36933102
79Spliceosome_Homo sapiens_hsa030400.34962565
80Propanoate metabolism_Homo sapiens_hsa006400.34320213
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32125544
82Graft-versus-host disease_Homo sapiens_hsa053320.31458171
83Mineral absorption_Homo sapiens_hsa049780.30412419
84RNA degradation_Homo sapiens_hsa030180.29218331
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27702356
86Lysosome_Homo sapiens_hsa041420.26113466
87Fatty acid biosynthesis_Homo sapiens_hsa000610.25790236
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24077637
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.22848592
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22239467
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21954637
92Starch and sucrose metabolism_Homo sapiens_hsa005000.21244487
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20060590
94Ovarian steroidogenesis_Homo sapiens_hsa049130.19627003
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18945945
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.17915487
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17571713
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16134329
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.16038964
100Amphetamine addiction_Homo sapiens_hsa050310.16029293

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »