EIF3K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.51170083
2viral transcription (GO:0019083)7.39413750
3translational termination (GO:0006415)7.13133761
4ribosomal small subunit biogenesis (GO:0042274)6.86362597
5maturation of SSU-rRNA (GO:0030490)6.30796242
6translational elongation (GO:0006414)6.21985792
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.21151015
8cotranslational protein targeting to membrane (GO:0006613)6.11178536
9protein targeting to ER (GO:0045047)6.07784261
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.77985869
11protein localization to endoplasmic reticulum (GO:0070972)5.71856004
12respiratory electron transport chain (GO:0022904)5.69283108
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.64800714
14viral life cycle (GO:0019058)5.61892872
15cellular protein complex disassembly (GO:0043624)5.61774088
16* translational initiation (GO:0006413)5.56394237
17electron transport chain (GO:0022900)5.54525512
18ribosomal large subunit biogenesis (GO:0042273)5.43681506
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.42320626
20chaperone-mediated protein transport (GO:0072321)5.26729626
21protein complex disassembly (GO:0043241)4.93844875
22DNA deamination (GO:0045006)4.68823732
23macromolecular complex disassembly (GO:0032984)4.65851303
24oxidative phosphorylation (GO:0006119)4.61728407
25ribonucleoprotein complex biogenesis (GO:0022613)4.49229699
26* translation (GO:0006412)4.45470471
27* formation of translation preinitiation complex (GO:0001731)4.39333715
28regulation of mitochondrial translation (GO:0070129)4.24687875
29protein complex biogenesis (GO:0070271)4.22079299
30nuclear-transcribed mRNA catabolic process (GO:0000956)4.20776878
31DNA strand elongation involved in DNA replication (GO:0006271)4.14195440
32mitochondrial respiratory chain complex I assembly (GO:0032981)4.13114045
33NADH dehydrogenase complex assembly (GO:0010257)4.13114045
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.13114045
35mitochondrial respiratory chain complex assembly (GO:0033108)4.12135503
36protein targeting to mitochondrion (GO:0006626)4.05920177
37telomere maintenance via semi-conservative replication (GO:0032201)4.05061273
38ATP biosynthetic process (GO:0006754)4.04870666
39protein targeting to membrane (GO:0006612)4.00309035
40mRNA catabolic process (GO:0006402)3.99635508
41inner mitochondrial membrane organization (GO:0007007)3.95926545
42DNA strand elongation (GO:0022616)3.94868945
43purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.87582909
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.85736657
45rRNA processing (GO:0006364)3.84822401
46establishment of protein localization to mitochondrion (GO:0072655)3.80248657
47RNA catabolic process (GO:0006401)3.78896645
48proteasome assembly (GO:0043248)3.76916461
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72802487
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.71258951
51termination of RNA polymerase III transcription (GO:0006386)3.71258951
52DNA replication initiation (GO:0006270)3.70564425
53rRNA metabolic process (GO:0016072)3.69977126
54establishment of integrated proviral latency (GO:0075713)3.68589528
55ribonucleoside triphosphate biosynthetic process (GO:0009201)3.64906457
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64834902
57spliceosomal snRNP assembly (GO:0000387)3.63862718
58protein localization to mitochondrion (GO:0070585)3.63288442
59cellular component biogenesis (GO:0044085)3.62240486
60telomere maintenance via recombination (GO:0000722)3.55271038
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.53082775
62hydrogen ion transmembrane transport (GO:1902600)3.47781265
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.46933515
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46239701
65negative regulation of ligase activity (GO:0051352)3.46101115
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46101115
67protein targeting (GO:0006605)3.44736110
68aerobic respiration (GO:0009060)3.44732769
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43510965
70mitochondrial transport (GO:0006839)3.42369267
71purine nucleoside monophosphate biosynthetic process (GO:0009127)3.42084488
72purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.42084488
73guanosine-containing compound biosynthetic process (GO:1901070)3.41045887
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40956555
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40881041
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40881041
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.38618432
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.38618432
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.38618432
80nucleobase biosynthetic process (GO:0046112)3.37507955
81energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37106661
82ATP synthesis coupled proton transport (GO:0015986)3.37106661
83signal transduction involved in DNA damage checkpoint (GO:0072422)3.33580205
84signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33580205
85GTP biosynthetic process (GO:0006183)3.32838343
86pseudouridine synthesis (GO:0001522)3.32050509
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.28902785
88ribosome biogenesis (GO:0042254)3.26616206
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26252214
90spliceosomal complex assembly (GO:0000245)3.25082893
91nucleoside triphosphate biosynthetic process (GO:0009142)3.24307935
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23429379
93DNA replication checkpoint (GO:0000076)3.23136318
94transcription-coupled nucleotide-excision repair (GO:0006283)3.22889489
95establishment of protein localization to organelle (GO:0072594)3.21569340
96mitotic recombination (GO:0006312)3.20681895
97nucleotide-excision repair, DNA gap filling (GO:0006297)3.19441901
987-methylguanosine mRNA capping (GO:0006370)3.19108376
99regulation of cellular amino acid metabolic process (GO:0006521)3.15450351
100telomere maintenance via telomere lengthening (GO:0010833)3.14990294
101RNA capping (GO:0036260)3.14778228
1027-methylguanosine RNA capping (GO:0009452)3.14778228
103purine nucleobase biosynthetic process (GO:0009113)3.13878319
104antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09511417
105protein neddylation (GO:0045116)3.07830791
106DNA unwinding involved in DNA replication (GO:0006268)3.05511871
107cullin deneddylation (GO:0010388)3.05428886
108establishment of viral latency (GO:0019043)3.03906638
109nucleoside monophosphate biosynthetic process (GO:0009124)3.03371751
110ribonucleoside monophosphate biosynthetic process (GO:0009156)3.03350192
111rRNA modification (GO:0000154)3.02968662
112respiratory chain complex IV assembly (GO:0008535)3.02870468
113pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.01573585
114cytochrome complex assembly (GO:0017004)3.01451772
115pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.99666690
116exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99497445
117pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.99110044
118establishment of protein localization to mitochondrial membrane (GO:0090151)2.98707109
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98403690
120nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95353768
121ribosome assembly (GO:0042255)2.93882215
122protein deneddylation (GO:0000338)2.91397749
123viral mRNA export from host cell nucleus (GO:0046784)2.91384291
124transcription from RNA polymerase I promoter (GO:0006360)2.87403183
125termination of RNA polymerase I transcription (GO:0006363)2.87331432
126CENP-A containing nucleosome assembly (GO:0034080)2.87187765
127positive regulation of ligase activity (GO:0051351)2.86198898
128transcription elongation from RNA polymerase I promoter (GO:0006362)2.86159207
129DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85426698
130DNA replication-dependent nucleosome organization (GO:0034723)2.84675648
131DNA replication-dependent nucleosome assembly (GO:0006335)2.84675648
132cell cycle G1/S phase transition (GO:0044843)2.84138632
133G1/S transition of mitotic cell cycle (GO:0000082)2.84138632
134ncRNA processing (GO:0034470)2.82027217
135positive regulation of cell cycle arrest (GO:0071158)2.81672329
136UTP biosynthetic process (GO:0006228)2.80385717
137chromatin remodeling at centromere (GO:0031055)2.79847722
138establishment of protein localization to membrane (GO:0090150)2.79500107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.16846322
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57104831
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.03334929
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.64661861
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57415094
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.56603274
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.42286222
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.30644161
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.27050697
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23223917
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07598763
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96130988
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.95973797
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92108760
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85432573
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83668280
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70162519
18XRN2_22483619_ChIP-Seq_HELA_Human2.65164200
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52973861
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45362412
21VDR_23849224_ChIP-Seq_CD4+_Human2.44414018
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29633337
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25589351
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.23907141
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22122970
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18422760
27DCP1A_22483619_ChIP-Seq_HELA_Human2.14244562
28TTF2_22483619_ChIP-Seq_HELA_Human2.11530135
29FOXP3_21729870_ChIP-Seq_TREG_Human2.10400291
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99370624
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93949988
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93617040
33ELK1_19687146_ChIP-ChIP_HELA_Human1.91514644
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.90687692
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90051808
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86340733
37GABP_19822575_ChIP-Seq_HepG2_Human1.85125021
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80449455
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77994754
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76699847
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75858223
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72297714
43* SRF_21415370_ChIP-Seq_HL-1_Mouse1.70666735
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59892039
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58508187
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53737563
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53616269
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52893041
49CIITA_25753668_ChIP-Seq_RAJI_Human1.47034752
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47007523
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42620539
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42328255
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40215679
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39742124
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37669708
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34957506
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34734710
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34151232
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33943973
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.33625545
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.33416668
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33297598
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32764097
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31792707
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29594985
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27816939
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27623555
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26710251
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22650353
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21985607
71AR_21909140_ChIP-Seq_LNCAP_Human1.19802701
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.17709099
73KDM5A_27292631_Chip-Seq_BREAST_Human1.17691883
74ZNF263_19887448_ChIP-Seq_K562_Human1.16016029
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14204478
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13620878
77MYC_22102868_ChIP-Seq_BL_Human1.10057778
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09899821
79MYC_18940864_ChIP-ChIP_HL60_Human1.09167215
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.06348334
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05184606
82* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05119753
83* SPI1_23547873_ChIP-Seq_NB4_Human1.04702896
84FOXP1_21924763_ChIP-Seq_HESCs_Human1.04405298
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03222892
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01920845
87* TFEB_21752829_ChIP-Seq_HELA_Human1.01838744
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.01573971
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00321657
90KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99182662
91OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99060726
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98709333
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98035381
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96304264
95VDR_21846776_ChIP-Seq_THP-1_Human0.95822955
96SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95632063
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95479518
98TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95465589
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.95108931
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94750359
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94750359
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94750359
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93370666
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93202911
105ELF1_20517297_ChIP-Seq_JURKAT_Human0.92597888
106SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92007227
107YY1_22570637_ChIP-Seq_MALME-3M_Human0.90299855
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88523931
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88462591
110BP1_19119308_ChIP-ChIP_Hs578T_Human0.88461624
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86486451
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85083763
113CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83822628
114P68_20966046_ChIP-Seq_HELA_Human0.82888337
115TP63_17297297_ChIP-ChIP_HaCaT_Human0.81919907
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81447522
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80292435
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80047691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.82817061
2MP0004957_abnormal_blastocyst_morpholog4.11186294
3MP0010094_abnormal_chromosome_stability3.66061099
4MP0009379_abnormal_foot_pigmentation3.56800512
5MP0003111_abnormal_nucleus_morphology3.54654833
6MP0003077_abnormal_cell_cycle3.45784464
7MP0008057_abnormal_DNA_replication3.39952349
8MP0008058_abnormal_DNA_repair3.00089995
9MP0008932_abnormal_embryonic_tissue2.51469278
10MP0008007_abnormal_cellular_replicative2.51310518
11MP0003786_premature_aging2.35057750
12MP0003646_muscle_fatigue2.02269674
13MP0002396_abnormal_hematopoietic_system2.01794017
14MP0009333_abnormal_splenocyte_physiolog1.92026956
15MP0005451_abnormal_body_composition1.85172251
16MP0002837_dystrophic_cardiac_calcinosis1.84929380
17MP0000490_abnormal_crypts_of1.82207345
18MP0003123_paternal_imprinting1.76784690
19MP0004145_abnormal_muscle_electrophysio1.74455432
20MP0000350_abnormal_cell_proliferation1.71990968
21MP0001730_embryonic_growth_arrest1.66843906
22MP0003315_abnormal_perineum_morphology1.63687391
23MP0003136_yellow_coat_color1.62244143
24MP0003186_abnormal_redox_activity1.60312660
25MP0003763_abnormal_thymus_physiology1.56595668
26MP0001835_abnormal_antigen_presentation1.49738546
27MP0002132_abnormal_respiratory_system1.48641306
28MP0003941_abnormal_skin_development1.46848173
29MP0000313_abnormal_cell_death1.40048248
30MP0004147_increased_porphyrin_level1.39770049
31MP0003718_maternal_effect1.34892788
32MP0002019_abnormal_tumor_incidence1.34739035
33MP0005670_abnormal_white_adipose1.34393923
34MP0010030_abnormal_orbit_morphology1.32715955
35MP0010352_gastrointestinal_tract_polyps1.30924912
36MP0002398_abnormal_bone_marrow1.29517613
37MP0005075_abnormal_melanosome_morpholog1.28029113
38MP0001697_abnormal_embryo_size1.25333478
39MP0001764_abnormal_homeostasis1.25196023
40MP0002722_abnormal_immune_system1.23843466
41MP0008877_abnormal_DNA_methylation1.22242891
42MP0002163_abnormal_gland_morphology1.21105220
43MP0000858_altered_metastatic_potential1.20920665
44MP0004808_abnormal_hematopoietic_stem1.20898000
45MP0000703_abnormal_thymus_morphology1.19743236
46MP0002148_abnormal_hypersensitivity_rea1.19407357
47MP0004185_abnormal_adipocyte_glucose1.18345880
48MP0002080_prenatal_lethality1.18066587
49MP0001853_heart_inflammation1.17933009
50MP0005330_cardiomyopathy1.17300928
51MP0003567_abnormal_fetal_cardiomyocyte1.15696916
52MP0005408_hypopigmentation1.15030984
53MP0000689_abnormal_spleen_morphology1.14568330
54MP0005671_abnormal_response_to1.13990356
55MP0006054_spinal_hemorrhage1.13136015
56MP0003806_abnormal_nucleotide_metabolis1.12519335
57MP0000685_abnormal_immune_system1.12231805
58MP0002938_white_spotting1.11995292
59MP0000749_muscle_degeneration1.10368293
60MP0009785_altered_susceptibility_to1.08505901
61MP0004133_heterotaxia1.08300226
62MP0005397_hematopoietic_system_phenotyp1.07712903
63MP0001545_abnormal_hematopoietic_system1.07712903
64MP0002429_abnormal_blood_cell1.07394100
65MP0003011_delayed_dark_adaptation1.06283023
66MP0005380_embryogenesis_phenotype1.04467646
67MP0001672_abnormal_embryogenesis/_devel1.04467646
68MP0002085_abnormal_embryonic_tissue1.03468777
69MP0000678_abnormal_parathyroid_gland1.02927967
70MP0000343_altered_response_to1.02387557
71MP0001800_abnormal_humoral_immune1.02060589
72MP0005332_abnormal_amino_acid1.01762642
73MP0000372_irregular_coat_pigmentation1.01534190
74MP0002405_respiratory_system_inflammati1.01340645
75MP0005379_endocrine/exocrine_gland_phen1.01013596
76MP0006292_abnormal_olfactory_placode1.00355212
77MP0002420_abnormal_adaptive_immunity0.99049391
78MP0000716_abnormal_immune_system0.98684056
79MP0005174_abnormal_tail_pigmentation0.97846862
80MP0001819_abnormal_immune_cell0.97688519
81MP0001905_abnormal_dopamine_level0.96685576
82MP0005266_abnormal_metabolism0.96264548
83MP0008995_early_reproductive_senescence0.95952353
84MP0002452_abnormal_antigen_presenting0.95273092
85MP0004381_abnormal_hair_follicle0.94675330
86MP0002160_abnormal_reproductive_system0.92602849
87MP0005501_abnormal_skin_physiology0.91564056
88MP0005025_abnormal_response_to0.91553991
89MP0003984_embryonic_growth_retardation0.90631363
90MP0005000_abnormal_immune_tolerance0.90111526
91MP0000358_abnormal_cell_content/0.89753317
92MP0001529_abnormal_vocalization0.89485880
93MP0006036_abnormal_mitochondrial_physio0.89464933
94MP0002210_abnormal_sex_determination0.89223214
95MP0001881_abnormal_mammary_gland0.88916006
96MP0002088_abnormal_embryonic_growth/wei0.88121551
97MP0002723_abnormal_immune_serum0.87838810
98MP0002822_catalepsy0.87783101
99MP0002277_abnormal_respiratory_mucosa0.87082260
100MP0009697_abnormal_copulation0.86916765
101MP0008789_abnormal_olfactory_epithelium0.86612788
102MP0002095_abnormal_skin_pigmentation0.86010441
103MP0010307_abnormal_tumor_latency0.85662042
104MP0005636_abnormal_mineral_homeostasis0.84670379
105MP0001661_extended_life_span0.83343240
106MP0003121_genomic_imprinting0.83288983
107MP0005058_abnormal_lysosome_morphology0.82863197
108MP0002084_abnormal_developmental_patter0.82331832
109MP0005319_abnormal_enzyme/_coenzyme0.78753879
110MP0002086_abnormal_extraembryonic_tissu0.77217212
111MP0001145_abnormal_male_reproductive0.76538699
112MP0004197_abnormal_fetal_growth/weight/0.75283744
113MP0000747_muscle_weakness0.74214211
114MP0002638_abnormal_pupillary_reflex0.73840516
115MP0003436_decreased_susceptibility_to0.72892656
116MP0006035_abnormal_mitochondrial_morpho0.72759241
117MP0005389_reproductive_system_phenotype0.72437772
118MP0001919_abnormal_reproductive_system0.72091570
119MP0005584_abnormal_enzyme/coenzyme_acti0.70654244
120MP0000537_abnormal_urethra_morphology0.70411939
121MP0001727_abnormal_embryo_implantation0.70281545
122MP0003448_altered_tumor_morphology0.70175120
123MP0001873_stomach_inflammation0.69844698
124MP0005666_abnormal_adipose_tissue0.69107900
125MP0000049_abnormal_middle_ear0.68058727
126MP0005023_abnormal_wound_healing0.68030791
127MP0001346_abnormal_lacrimal_gland0.67938802
128MP0001293_anophthalmia0.67575574
129MP0002751_abnormal_autonomic_nervous0.67069041
130MP0000750_abnormal_muscle_regeneration0.65086712
131MP0001986_abnormal_taste_sensitivity0.64489218
132MP0005083_abnormal_biliary_tract0.64036129
133MP0000759_abnormal_skeletal_muscle0.62558718
134MP0004142_abnormal_muscle_tone0.61957370
135MP0005084_abnormal_gallbladder_morpholo0.59218488
136MP0001929_abnormal_gametogenesis0.58461281
137MP0004233_abnormal_muscle_weight0.57601656
138MP0004019_abnormal_vitamin_homeostasis0.57481633
139MP0009643_abnormal_urine_homeostasis0.55690145

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.49285047
2Abnormal number of erythroid precursors (HP:0012131)6.83902528
3Reticulocytopenia (HP:0001896)6.73020851
4Macrocytic anemia (HP:0001972)4.90220099
5Pallor (HP:0000980)4.59140970
6Increased muscle lipid content (HP:0009058)4.28742298
7Cerebral edema (HP:0002181)4.14983558
8Birth length less than 3rd percentile (HP:0003561)3.68771732
9Aplasia/Hypoplasia of the sacrum (HP:0008517)3.51694967
10Acute necrotizing encephalopathy (HP:0006965)3.48213845
11Aplastic anemia (HP:0001915)3.39488852
12Mitochondrial inheritance (HP:0001427)3.31341268
13Breast hypoplasia (HP:0003187)3.20214694
14Abnormal mitochondria in muscle tissue (HP:0008316)3.13860809
15Increased hepatocellular lipid droplets (HP:0006565)3.11649231
16Oral leukoplakia (HP:0002745)3.09662023
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03154509
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03154509
19Rough bone trabeculation (HP:0100670)2.98605019
20Microvesicular hepatic steatosis (HP:0001414)2.97945652
21Ragged-red muscle fibers (HP:0003200)2.97943849
22Colon cancer (HP:0003003)2.95357544
23Carpal bone hypoplasia (HP:0001498)2.95058243
2411 pairs of ribs (HP:0000878)2.92585647
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.91535306
26Cerebral hypomyelination (HP:0006808)2.91205096
27Absent thumb (HP:0009777)2.90176198
28Leukodystrophy (HP:0002415)2.87379583
29Increased CSF lactate (HP:0002490)2.87194496
30Hepatocellular necrosis (HP:0001404)2.86222022
31Trismus (HP:0000211)2.82241898
32Selective tooth agenesis (HP:0001592)2.75592815
33Multiple enchondromatosis (HP:0005701)2.72146867
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70832576
35Exertional dyspnea (HP:0002875)2.68601478
36Optic disc pallor (HP:0000543)2.64131261
37Progressive macrocephaly (HP:0004481)2.60675764
38Abnormality of renal resorption (HP:0011038)2.59510502
39Lipid accumulation in hepatocytes (HP:0006561)2.58636275
40Patellar aplasia (HP:0006443)2.55990306
41Thrombocytosis (HP:0001894)2.54105855
42Lethargy (HP:0001254)2.51884162
43Progressive muscle weakness (HP:0003323)2.50882418
44Acute encephalopathy (HP:0006846)2.46543463
45Type I transferrin isoform profile (HP:0003642)2.45902458
46Aplasia/Hypoplasia of the patella (HP:0006498)2.42694233
47Renal Fanconi syndrome (HP:0001994)2.37970227
48Increased serum lactate (HP:0002151)2.37666911
493-Methylglutaconic aciduria (HP:0003535)2.36622497
50Cleft eyelid (HP:0000625)2.34502293
51Hepatic necrosis (HP:0002605)2.32953918
52Respiratory difficulties (HP:0002880)2.32814624
53IgM deficiency (HP:0002850)2.31201852
54Glycosuria (HP:0003076)2.28746181
55Abnormality of urine glucose concentration (HP:0011016)2.28746181
56Emotional lability (HP:0000712)2.27095788
57Stenosis of the external auditory canal (HP:0000402)2.26173687
58Generalized aminoaciduria (HP:0002909)2.24668175
59Abnormality of reticulocytes (HP:0004312)2.24218740
60Reduced antithrombin III activity (HP:0001976)2.23754633
61Degeneration of anterior horn cells (HP:0002398)2.23150304
62Abnormality of the anterior horn cell (HP:0006802)2.23150304
63CNS demyelination (HP:0007305)2.22975390
64Depressed nasal ridge (HP:0000457)2.21727316
65Exercise intolerance (HP:0003546)2.21142843
66Premature graying of hair (HP:0002216)2.20829306
67Abnormal trabecular bone morphology (HP:0100671)2.18810056
68Premature ovarian failure (HP:0008209)2.17930125
69Triphalangeal thumb (HP:0001199)2.17427195
70Agnosia (HP:0010524)2.16903016
71Microretrognathia (HP:0000308)2.16318082
72Abnormality of the preputium (HP:0100587)2.16211627
73Rhabdomyolysis (HP:0003201)2.15149837
74Absent radius (HP:0003974)2.14649077
75Abnormal number of incisors (HP:0011064)2.14083402
76Testicular atrophy (HP:0000029)2.13248786
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09692469
78Dicarboxylic aciduria (HP:0003215)2.09692469
79Sparse eyelashes (HP:0000653)2.09597818
80Asplenia (HP:0001746)2.09441036
81Meckel diverticulum (HP:0002245)2.08935734
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07842357
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.07077260
84Secondary amenorrhea (HP:0000869)2.06609475
85Increased intramyocellular lipid droplets (HP:0012240)2.06438674
86Hypoplasia of the radius (HP:0002984)2.05955399
87Myopathic facies (HP:0002058)2.04157633
88Glossoptosis (HP:0000162)2.02516991
89Hyperphosphaturia (HP:0003109)2.02277398
90Abnormality of the ileum (HP:0001549)2.02176796
91Horseshoe kidney (HP:0000085)2.01879667
92Nausea (HP:0002018)2.00938360
93Congenital, generalized hypertrichosis (HP:0004540)1.99016099
94Supernumerary spleens (HP:0009799)1.97963850
95Chromsome breakage (HP:0040012)1.97511863
96Abnormal protein glycosylation (HP:0012346)1.97211098
97Abnormal glycosylation (HP:0012345)1.97211098
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97211098
99Abnormal protein N-linked glycosylation (HP:0012347)1.97211098
100Aplasia involving forearm bones (HP:0009822)1.97090137
101Absent forearm bone (HP:0003953)1.97090137
102Myelodysplasia (HP:0002863)1.95987037
103Cellular immunodeficiency (HP:0005374)1.93262980
104X-linked dominant inheritance (HP:0001423)1.93123977
105Respiratory failure (HP:0002878)1.92568753
106Abnormal hemoglobin (HP:0011902)1.91884656
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91331429
108Pancytopenia (HP:0001876)1.91029238
109Neoplasm of the pancreas (HP:0002894)1.90337477
110Aplasia/Hypoplasia of the spleen (HP:0010451)1.89110519
111Muscle fiber atrophy (HP:0100295)1.87388399
112Duplicated collecting system (HP:0000081)1.86262238
113Bone marrow hypocellularity (HP:0005528)1.86159104
114Abnormal lung lobation (HP:0002101)1.85060305
115Missing ribs (HP:0000921)1.84619524
116Abnormality of the heme biosynthetic pathway (HP:0010472)1.84556255
117Esophageal neoplasm (HP:0100751)1.83907362
118Neoplasm of head and neck (HP:0012288)1.83907362
119Abnormality of alanine metabolism (HP:0010916)1.83529061
120Hyperalaninemia (HP:0003348)1.83529061
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83529061
122Paralysis (HP:0003470)1.82633571
123Petechiae (HP:0000967)1.81175548
124Elevated erythrocyte sedimentation rate (HP:0003565)1.80877865
125Lymphoma (HP:0002665)1.80840976
126Atresia of the external auditory canal (HP:0000413)1.79370810
127Gliosis (HP:0002171)1.78438633
128Vomiting (HP:0002013)1.78260710
129Tracheoesophageal fistula (HP:0002575)1.77745162
130Abnormality of glycolysis (HP:0004366)1.76427267
131Increased serum pyruvate (HP:0003542)1.76427267
132Lactic acidosis (HP:0003128)1.75114742
133Methylmalonic aciduria (HP:0012120)1.73987453
134Facial cleft (HP:0002006)1.69025061
135Hypertensive crisis (HP:0100735)1.68714167
136Poor head control (HP:0002421)1.68519103
137Muscle fiber inclusion bodies (HP:0100299)1.67057179
138Nemaline bodies (HP:0003798)1.67038115
139Abnormality of the renal collecting system (HP:0004742)1.66980311
140Myoglobinuria (HP:0002913)1.64548515
141Abnormality of placental membranes (HP:0011409)1.64190852
142Amniotic constriction ring (HP:0009775)1.64190852
143Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.60374638
144Tinnitus (HP:0000360)1.58417501
145Abnormal urine phosphate concentration (HP:0012599)1.57439013
146Gout (HP:0001997)1.56126554
147Abnormal gallbladder physiology (HP:0012438)1.55557442
148Cholecystitis (HP:0001082)1.55557442
149Hyperthyroidism (HP:0000836)1.55278242
150Blindness (HP:0000618)1.55273366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.33543752
2BUB14.54266073
3NME24.38303278
4WEE13.79631846
5STK162.72702883
6SRPK12.62346192
7CDC72.56293758
8TLK12.54864980
9PDK22.47181305
10PIM22.47157891
11VRK12.40164839
12EIF2AK12.27023913
13RPS6KB22.21136291
14TSSK62.03558001
15EIF2AK31.93825109
16TESK21.80959333
17PLK41.73584531
18MST41.72078218
19TRIB31.70149105
20SMG11.69599897
21DYRK31.68888148
22NME11.62392332
23PASK1.61321290
24LRRK21.47830545
25PLK11.43271972
26EPHA21.42900144
27TGFBR11.39307982
28CDK71.39083916
29AURKB1.38778788
30TTK1.38425291
31MAP4K11.31741735
32BRSK21.30682880
33NEK21.28222928
34MKNK11.26867031
35ACVR1B1.25773560
36KDR1.24116531
37AURKA1.23426689
38MAPKAPK31.22686132
39ZAK1.21403670
40OBSCN1.16115526
41TESK11.15286294
42PBK1.14987810
43PIM11.14107773
44ATR1.12687159
45STK101.11457221
46BLK1.06841471
47PAK41.05581245
48MAP3K121.03578925
49ILK1.00570399
50TAF10.99425086
51MAP3K80.99366051
52PLK30.97342651
53RPS6KA40.95146297
54NEK10.89636093
55MAP3K110.88700332
56RPS6KA50.85018589
57PHKG10.83877662
58PHKG20.83877662
59CSNK2A20.82049590
60STK40.80640579
61CSNK2A10.80190104
62BTK0.79295414
63CHEK20.78650403
64ZAP700.77745428
65CDK190.77196499
66MAP2K30.76255330
67PAK10.76078856
68IKBKB0.75225926
69MKNK20.74613664
70DYRK20.73329891
71EEF2K0.73115282
72LIMK10.70844456
73MYLK0.70272493
74CDK80.68698943
75MAP3K30.68697154
76BRAF0.68357530
77RIPK40.68107056
78IRAK40.68050136
79IRAK30.67623858
80TEC0.67437767
81BCKDK0.66613655
82CHEK10.66402585
83PRKCI0.65056132
84EIF2AK20.65032152
85CCNB10.64964470
86GRK60.64948067
87BRSK10.63663393
88ARAF0.60128454
89TXK0.59878116
90CLK10.58353927
91TAOK20.58313337
92CDK40.57672186
93FLT30.57381197
94IRAK20.57364076
95AKT20.56610616
96MAPKAPK50.53722021
97DAPK30.53492190
98SYK0.52665137
99SCYL20.50484480
100DAPK10.50168699
101ERN10.46302068
102CDK20.46054534
103ABL20.45802047
104MAP2K60.44794881
105LYN0.43090137
106KIT0.42912753
107MUSK0.42689686
108MAP2K20.42660770
109ATM0.42519651
110TYK20.40183628
111ALK0.39111296
112STK240.37623366
113MAP3K100.36569574
114YES10.35559027
115MAPKAPK20.32977485
116RPS6KA60.31449052
117LCK0.31415708
118NUAK10.30660955
119EPHB20.29735284
120CSNK1G30.29358505
121MARK30.29223503
122TBK10.24808803
123CSNK1E0.24711776
124MAPK120.24392203
125CAMK2G0.23771691
126PRKG20.23384490
127CDK11A0.22879580
128PRKCD0.22025703
129CDK10.21398539
130RPS6KA10.19234584

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.12379431
2Proteasome_Homo sapiens_hsa030504.23346540
3DNA replication_Homo sapiens_hsa030304.07541039
4RNA polymerase_Homo sapiens_hsa030203.74124668
5Mismatch repair_Homo sapiens_hsa034303.52857781
6Spliceosome_Homo sapiens_hsa030403.05823753
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90608724
8Base excision repair_Homo sapiens_hsa034102.56098982
9Pyrimidine metabolism_Homo sapiens_hsa002402.54096060
10Nucleotide excision repair_Homo sapiens_hsa034202.50160718
11Homologous recombination_Homo sapiens_hsa034402.49768618
12RNA transport_Homo sapiens_hsa030132.39630306
13Oxidative phosphorylation_Homo sapiens_hsa001902.30152196
14Parkinsons disease_Homo sapiens_hsa050122.14748950
15Protein export_Homo sapiens_hsa030601.84894566
16Huntingtons disease_Homo sapiens_hsa050161.75837702
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74593677
18One carbon pool by folate_Homo sapiens_hsa006701.74592672
19Cell cycle_Homo sapiens_hsa041101.74245998
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71521717
21Basal transcription factors_Homo sapiens_hsa030221.68509740
22Fanconi anemia pathway_Homo sapiens_hsa034601.62805778
23Non-homologous end-joining_Homo sapiens_hsa034501.62727185
24RNA degradation_Homo sapiens_hsa030181.60762274
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46911735
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41641002
27Purine metabolism_Homo sapiens_hsa002301.35237003
28Alzheimers disease_Homo sapiens_hsa050101.33701306
29Pyruvate metabolism_Homo sapiens_hsa006201.29135570
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25658774
31p53 signaling pathway_Homo sapiens_hsa041151.21321172
32Epstein-Barr virus infection_Homo sapiens_hsa051691.17744396
33mRNA surveillance pathway_Homo sapiens_hsa030151.05803788
34Systemic lupus erythematosus_Homo sapiens_hsa053221.01969632
35Fatty acid elongation_Homo sapiens_hsa000621.01140452
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97968792
37Primary immunodeficiency_Homo sapiens_hsa053400.90657164
38Sulfur metabolism_Homo sapiens_hsa009200.90182308
39Antigen processing and presentation_Homo sapiens_hsa046120.88342125
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.80218922
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78971078
42Herpes simplex infection_Homo sapiens_hsa051680.78892840
43Folate biosynthesis_Homo sapiens_hsa007900.77645735
44Glutathione metabolism_Homo sapiens_hsa004800.77003566
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76668116
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71345324
47Sulfur relay system_Homo sapiens_hsa041220.71257772
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68008422
49Viral carcinogenesis_Homo sapiens_hsa052030.64390471
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64312493
51Pentose phosphate pathway_Homo sapiens_hsa000300.60391716
52Collecting duct acid secretion_Homo sapiens_hsa049660.60104377
53Legionellosis_Homo sapiens_hsa051340.56479237
54Graft-versus-host disease_Homo sapiens_hsa053320.52380022
55Propanoate metabolism_Homo sapiens_hsa006400.51574455
56Allograft rejection_Homo sapiens_hsa053300.51563664
57Arginine and proline metabolism_Homo sapiens_hsa003300.49963612
58Arachidonic acid metabolism_Homo sapiens_hsa005900.49221240
59HTLV-I infection_Homo sapiens_hsa051660.49036770
60Asthma_Homo sapiens_hsa053100.48713229
61Hematopoietic cell lineage_Homo sapiens_hsa046400.45863552
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.45062390
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45054613
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44828238
65Cardiac muscle contraction_Homo sapiens_hsa042600.44802168
66Peroxisome_Homo sapiens_hsa041460.44021920
67Measles_Homo sapiens_hsa051620.42989329
68Apoptosis_Homo sapiens_hsa042100.41578225
69Tyrosine metabolism_Homo sapiens_hsa003500.41171522
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39865966
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.37812769
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.37619913
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37535037
74Metabolic pathways_Homo sapiens_hsa011000.37388430
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36942107
76Alcoholism_Homo sapiens_hsa050340.36458085
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35998136
78Vitamin B6 metabolism_Homo sapiens_hsa007500.35751327
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34961322
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.34881327
81Oocyte meiosis_Homo sapiens_hsa041140.34832811
82Phenylalanine metabolism_Homo sapiens_hsa003600.34312917
83Shigellosis_Homo sapiens_hsa051310.33492755
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32218041
85Biosynthesis of amino acids_Homo sapiens_hsa012300.31205945
86Arginine biosynthesis_Homo sapiens_hsa002200.29948082
87N-Glycan biosynthesis_Homo sapiens_hsa005100.29702041
88Selenocompound metabolism_Homo sapiens_hsa004500.29527869
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29142280
90Autoimmune thyroid disease_Homo sapiens_hsa053200.29067975
91Galactose metabolism_Homo sapiens_hsa000520.28312720
92Other glycan degradation_Homo sapiens_hsa005110.27464263
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27401204
94Thyroid cancer_Homo sapiens_hsa052160.27202713
95Notch signaling pathway_Homo sapiens_hsa043300.26013092
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24566532
97Fructose and mannose metabolism_Homo sapiens_hsa000510.24469895
98Basal cell carcinoma_Homo sapiens_hsa052170.23734412
99Vibrio cholerae infection_Homo sapiens_hsa051100.23298182
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22914309
101Vitamin digestion and absorption_Homo sapiens_hsa049770.21405475
102Leishmaniasis_Homo sapiens_hsa051400.21345837
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21267805
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21188432
105Influenza A_Homo sapiens_hsa051640.19452099
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18308347
107Hepatitis B_Homo sapiens_hsa051610.18244873
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17584303
109TGF-beta signaling pathway_Homo sapiens_hsa043500.15751951
110HIF-1 signaling pathway_Homo sapiens_hsa040660.15548556
111Small cell lung cancer_Homo sapiens_hsa052220.15170485
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15134222
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15109296
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14995012
115Regulation of autophagy_Homo sapiens_hsa041400.14714894
116Fatty acid degradation_Homo sapiens_hsa000710.14323879
117Malaria_Homo sapiens_hsa051440.12435863
118Fatty acid metabolism_Homo sapiens_hsa012120.12397704
119Renin-angiotensin system_Homo sapiens_hsa046140.11042277
120Carbon metabolism_Homo sapiens_hsa012000.10815823
121Rheumatoid arthritis_Homo sapiens_hsa053230.10636363
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10389552
123Pathways in cancer_Homo sapiens_hsa052000.10096474
124Linoleic acid metabolism_Homo sapiens_hsa005910.09938860
125Hippo signaling pathway_Homo sapiens_hsa043900.08979201
126Chemical carcinogenesis_Homo sapiens_hsa052040.07552378
127Fat digestion and absorption_Homo sapiens_hsa049750.07049545
128Tryptophan metabolism_Homo sapiens_hsa003800.02827660
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.02231823
130Butanoate metabolism_Homo sapiens_hsa006500.02184824

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