EIF3IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.70956274
2fucose catabolic process (GO:0019317)4.75820382
3L-fucose metabolic process (GO:0042354)4.75820382
4L-fucose catabolic process (GO:0042355)4.75820382
5proteasome assembly (GO:0043248)4.16223884
6platelet dense granule organization (GO:0060155)4.04614571
7positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.01110322
8negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.92983461
9maturation of SSU-rRNA (GO:0030490)3.79452907
10regulation of cellular amino acid metabolic process (GO:0006521)3.76316446
11maturation of 5.8S rRNA (GO:0000460)3.74956017
12somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.74360172
13isotype switching (GO:0045190)3.74360172
14somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.74360172
15cellular response to ATP (GO:0071318)3.72021653
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70337437
17cullin deneddylation (GO:0010388)3.68409854
18NADH dehydrogenase complex assembly (GO:0010257)3.67229604
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67229604
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.67229604
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66071799
22exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59810693
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59070857
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59070857
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59070857
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.58945173
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54628032
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54628032
29chaperone-mediated protein transport (GO:0072321)3.51865934
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.49056363
31regulation of isotype switching to IgG isotypes (GO:0048302)3.47581459
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45846999
33ATP synthesis coupled proton transport (GO:0015986)3.45846999
34base-excision repair, AP site formation (GO:0006285)3.45618540
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44842443
36protein deneddylation (GO:0000338)3.41941697
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.39148138
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39148138
39regulation of immunoglobulin secretion (GO:0051023)3.37499368
40negative regulation of B cell apoptotic process (GO:0002903)3.37216594
41aldehyde catabolic process (GO:0046185)3.37169471
42protein complex biogenesis (GO:0070271)3.36408711
43positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.34474508
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.32952073
45high-density lipoprotein particle remodeling (GO:0034375)3.30600122
46regulation of cytokine secretion involved in immune response (GO:0002739)3.29868743
47water-soluble vitamin biosynthetic process (GO:0042364)3.29705297
48response to pheromone (GO:0019236)3.26459662
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.24795085
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21049012
51regulation of cholesterol esterification (GO:0010872)3.19468483
52dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.17704561
53rRNA catabolic process (GO:0016075)3.16183779
54plasma membrane fusion (GO:0045026)3.15386413
55cytidine metabolic process (GO:0046087)3.12294050
56cytidine catabolic process (GO:0006216)3.12294050
57cytidine deamination (GO:0009972)3.12294050
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06104571
59negative regulation of ligase activity (GO:0051352)3.06104571
60mitochondrial respiratory chain complex assembly (GO:0033108)3.05426850
61regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.03077837
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00122446
63regulation of regulatory T cell differentiation (GO:0045589)2.98448456
64regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.98330543
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96056086
66positive regulation of interleukin-17 production (GO:0032740)2.95118480
67reverse cholesterol transport (GO:0043691)2.92273249
68phospholipid homeostasis (GO:0055091)2.90999759
69regulation of heterotypic cell-cell adhesion (GO:0034114)2.90915110
70electron transport chain (GO:0022900)2.89205795
71respiratory electron transport chain (GO:0022904)2.88317533
72negative regulation of interleukin-1 beta production (GO:0032691)2.87915489
73pseudouridine synthesis (GO:0001522)2.86924658
74amine catabolic process (GO:0009310)2.84645914
75cellular biogenic amine catabolic process (GO:0042402)2.84645914
76establishment of protein localization to mitochondrial membrane (GO:0090151)2.84343822
77signal peptide processing (GO:0006465)2.83448091
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.83290298
79termination of RNA polymerase III transcription (GO:0006386)2.79875790
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.79875790
81mannosylation (GO:0097502)2.79197566
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78988888
83regulation of interleukin-1 beta secretion (GO:0050706)2.75808914
84positive regulation of cell cycle arrest (GO:0071158)2.75791051
85nucleotide transmembrane transport (GO:1901679)2.70992228
86protein neddylation (GO:0045116)2.69978513
87antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.68761327
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68126994
89rRNA modification (GO:0000154)2.65969786
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.65448172
91GDP-mannose metabolic process (GO:0019673)2.64384926
92xenobiotic catabolic process (GO:0042178)2.62982054
93positive regulation of ligase activity (GO:0051351)2.61356522
94detection of light stimulus involved in visual perception (GO:0050908)2.60353763
95detection of light stimulus involved in sensory perception (GO:0050962)2.60353763
96negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.54250495
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53767714
98regulation of cellular amine metabolic process (GO:0033238)2.53699322
99ADP metabolic process (GO:0046031)2.52087136
100positive regulation of isotype switching (GO:0045830)2.50158961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.69780718
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.89567693
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38219590
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.18285633
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18220648
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78175913
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75488308
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.53977053
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44040498
10VDR_23849224_ChIP-Seq_CD4+_Human2.41341759
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37163153
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31257927
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26884739
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25485933
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.22437061
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21559057
17ZNF274_21170338_ChIP-Seq_K562_Hela2.19602870
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.08931173
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.08373049
20FOXP3_21729870_ChIP-Seq_TREG_Human2.07744306
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06181066
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.04142367
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97807872
24ELK1_19687146_ChIP-ChIP_HELA_Human1.94308527
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94273237
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91355329
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88096102
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84952654
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82349023
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79051931
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.75397725
32MYC_18940864_ChIP-ChIP_HL60_Human1.71383297
33IRF1_19129219_ChIP-ChIP_H3396_Human1.70957402
34VDR_22108803_ChIP-Seq_LS180_Human1.66163727
35* EWS_26573619_Chip-Seq_HEK293_Human1.60298492
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.55619047
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55311646
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54099997
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48944855
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44401963
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43482760
42* P300_19829295_ChIP-Seq_ESCs_Human1.38534409
43AR_20517297_ChIP-Seq_VCAP_Human1.37427826
44GATA3_26560356_Chip-Seq_TH2_Human1.37389036
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.36352552
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36103980
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33668338
48TP53_22573176_ChIP-Seq_HFKS_Human1.33179076
49IGF1R_20145208_ChIP-Seq_DFB_Human1.32061006
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30114170
51NANOG_19829295_ChIP-Seq_ESCs_Human1.29431958
52SOX2_19829295_ChIP-Seq_ESCs_Human1.29431958
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29199441
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28339988
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27658374
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.27658374
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26238009
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.23000338
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22393766
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22000230
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.21030961
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18926479
63MYC_19829295_ChIP-Seq_ESCs_Human1.17181866
64FOXH1_21741376_ChIP-Seq_EPCs_Human1.17090552
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.17079817
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.16084278
67SALL4_22934838_ChIP-ChIP_CD34+_Human1.15076919
68DCP1A_22483619_ChIP-Seq_HELA_Human1.12512646
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.12278123
70GBX2_23144817_ChIP-Seq_PC3_Human1.11813277
71TAF15_26573619_Chip-Seq_HEK293_Human1.08743729
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08110220
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.04725576
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.04090250
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03268819
76HOXB7_26014856_ChIP-Seq_BT474_Human1.03030511
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.02879059
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01223577
79* ER_23166858_ChIP-Seq_MCF-7_Human0.99855322
80BCAT_22108803_ChIP-Seq_LS180_Human0.99274126
81GABP_19822575_ChIP-Seq_HepG2_Human0.98593817
82CDX2_22108803_ChIP-Seq_LS180_Human0.97096138
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96955667
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96423436
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96364724
86MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96129935
87TCF4_22108803_ChIP-Seq_LS180_Human0.95184338
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94122098
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94034633
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93310667
91CBP_20019798_ChIP-Seq_JUKART_Human0.93310667
92HTT_18923047_ChIP-ChIP_STHdh_Human0.91434824
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90659601
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90213219
95NANOG_20526341_ChIP-Seq_ESCs_Human0.88932344
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88212151
97E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87785692
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85719385
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84807619
100* TAF2_19829295_ChIP-Seq_ESCs_Human0.84625326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH3.68367561
2MP0002138_abnormal_hepatobiliary_system3.51973530
3MP0004147_increased_porphyrin_level3.49176871
4MP0001835_abnormal_antigen_presentation2.99301069
5MP0002736_abnormal_nociception_after2.94738041
6MP0008872_abnormal_physiological_respon2.86226062
7MP0005085_abnormal_gallbladder_physiolo2.72150516
8MP0008875_abnormal_xenobiotic_pharmacok2.66765762
9MP0005671_abnormal_response_to2.66581211
10MP0006054_spinal_hemorrhage2.60184401
11MP0000372_irregular_coat_pigmentation2.47725076
12MP0002006_tumorigenesis2.31079665
13MP0009840_abnormal_foam_cell2.23902472
14MP0003806_abnormal_nucleotide_metabolis2.22389808
15MP0003300_gastrointestinal_ulcer2.21929890
16MP0001968_abnormal_touch/_nociception2.16439757
17MP0000465_gastrointestinal_hemorrhage2.13292338
18MP0003693_abnormal_embryo_hatching2.07081455
19MP0001986_abnormal_taste_sensitivity1.98452841
20MP0005365_abnormal_bile_salt1.91545150
21MP0004142_abnormal_muscle_tone1.88627128
22MP0002166_altered_tumor_susceptibility1.86131881
23MP0003045_fibrosis1.81710197
24MP0002148_abnormal_hypersensitivity_rea1.81193588
25MP0004885_abnormal_endolymph1.80776844
26MP0005464_abnormal_platelet_physiology1.78009658
27MP0003186_abnormal_redox_activity1.77850769
28MP0005645_abnormal_hypothalamus_physiol1.74473819
29MP0009785_altered_susceptibility_to1.73817044
30MP0003252_abnormal_bile_duct1.70077602
31MP0002102_abnormal_ear_morphology1.65655959
32MP0006036_abnormal_mitochondrial_physio1.63314565
33MP0003195_calcinosis1.54151599
34MP0001790_abnormal_immune_system1.53534100
35MP0005387_immune_system_phenotype1.53534100
36MP0010329_abnormal_lipoprotein_level1.51444017
37MP0006072_abnormal_retinal_apoptosis1.48155430
38MP0004145_abnormal_muscle_electrophysio1.43792712
39MP0005075_abnormal_melanosome_morpholog1.41556808
40MP0005636_abnormal_mineral_homeostasis1.41259220
41MP0003724_increased_susceptibility_to1.38806268
42MP0002139_abnormal_hepatobiliary_system1.36674741
43MP0001800_abnormal_humoral_immune1.36317563
44MP0009764_decreased_sensitivity_to1.34240819
45MP0001853_heart_inflammation1.32467303
46MP0006035_abnormal_mitochondrial_morpho1.31681013
47MP0000685_abnormal_immune_system1.29527488
48MP0003011_delayed_dark_adaptation1.27100297
49MP0001666_abnormal_nutrient_absorption1.25764684
50MP0001664_abnormal_digestion1.25000791
51MP0003191_abnormal_cellular_cholesterol1.24503916
52MP0005084_abnormal_gallbladder_morpholo1.22895452
53MP0005000_abnormal_immune_tolerance1.22643675
54MP0001529_abnormal_vocalization1.20268356
55MP0003718_maternal_effect1.16841262
56MP0001764_abnormal_homeostasis1.14337681
57MP0005332_abnormal_amino_acid1.12866732
58MP0009333_abnormal_splenocyte_physiolog1.12496994
59MP0005410_abnormal_fertilization1.11519855
60MP0005083_abnormal_biliary_tract1.11459789
61MP0008058_abnormal_DNA_repair1.09122726
62MP0009697_abnormal_copulation1.08354996
63MP0002837_dystrophic_cardiac_calcinosis1.07054135
64MP0002452_abnormal_antigen_presenting1.06592558
65MP0002876_abnormal_thyroid_physiology1.02898680
66MP0002723_abnormal_immune_serum1.02447480
67MP0005253_abnormal_eye_physiology0.98701812
68MP0001919_abnormal_reproductive_system0.97756130
69MP0000230_abnormal_systemic_arterial0.92122083
70MP0005646_abnormal_pituitary_gland0.91434409
71MP0005551_abnormal_eye_electrophysiolog0.91216822
72MP0006276_abnormal_autonomic_nervous0.91206181
73MP0002420_abnormal_adaptive_immunity0.88055350
74MP0003646_muscle_fatigue0.87617203
75MP0010155_abnormal_intestine_physiology0.87609274
76MP0001819_abnormal_immune_cell0.86278453
77MP0001440_abnormal_grooming_behavior0.85786439
78MP0003763_abnormal_thymus_physiology0.85551357
79MP0000639_abnormal_adrenal_gland0.85143657
80MP0009046_muscle_twitch0.82468549
81MP0005584_abnormal_enzyme/coenzyme_acti0.82464879
82MP0004957_abnormal_blastocyst_morpholog0.82313887
83MP0001873_stomach_inflammation0.82277383
84MP0004019_abnormal_vitamin_homeostasis0.80751767
85MP0001845_abnormal_inflammatory_respons0.80311879
86MP0005379_endocrine/exocrine_gland_phen0.80117926
87MP0001663_abnormal_digestive_system0.77677679
88MP0003436_decreased_susceptibility_to0.76338802
89MP0005025_abnormal_response_to0.75575794
90MP0002405_respiratory_system_inflammati0.75523576
91MP0002272_abnormal_nervous_system0.74439179
92MP0001970_abnormal_pain_threshold0.74048422
93MP0001501_abnormal_sleep_pattern0.71988808
94MP0005389_reproductive_system_phenotype0.71593177
95MP0008877_abnormal_DNA_methylation0.71559059
96MP0000689_abnormal_spleen_morphology0.70399752
97MP0005535_abnormal_body_temperature0.69394143
98MP0000470_abnormal_stomach_morphology0.68748009
99MP0005395_other_phenotype0.67420695
100MP0001765_abnormal_ion_homeostasis0.67101448

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.00036450
2Abnormal mitochondria in muscle tissue (HP:0008316)4.67904438
3Acute encephalopathy (HP:0006846)4.62871113
4Type I transferrin isoform profile (HP:0003642)4.38371714
5Hypoproteinemia (HP:0003075)4.36333453
6Reduced antithrombin III activity (HP:0001976)4.26285301
7Progressive macrocephaly (HP:0004481)4.19777277
8Mitochondrial inheritance (HP:0001427)3.80533510
9Increased CSF lactate (HP:0002490)3.70579245
10Abnormal protein glycosylation (HP:0012346)3.47906547
11Abnormal glycosylation (HP:0012345)3.47906547
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.47906547
13Abnormal protein N-linked glycosylation (HP:0012347)3.47906547
14Stomatitis (HP:0010280)3.43396551
15Cerebral edema (HP:0002181)3.42075127
16Hepatocellular necrosis (HP:0001404)3.41173642
17Hepatic necrosis (HP:0002605)3.29435838
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.23082335
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.23082335
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.22877504
21Hypomagnesemia (HP:0002917)3.11813930
22Increased serum lactate (HP:0002151)2.97529062
23Spontaneous abortion (HP:0005268)2.78781799
24Abnormality of the pons (HP:0007361)2.68945645
25Hypoplasia of the pons (HP:0012110)2.64780100
26Decreased central vision (HP:0007663)2.63363422
27Increased intramyocellular lipid droplets (HP:0012240)2.63094475
283-Methylglutaconic aciduria (HP:0003535)2.62342463
29Elevated erythrocyte sedimentation rate (HP:0003565)2.55390243
30Lactic acidosis (HP:0003128)2.55165446
31Chronic hepatic failure (HP:0100626)2.53047546
32Abnormality of magnesium homeostasis (HP:0004921)2.52715524
33Exercise intolerance (HP:0003546)2.52379327
34Abnormality of DNA repair (HP:0003254)2.49128967
35Abnormal rod and cone electroretinograms (HP:0008323)2.44935498
36Attenuation of retinal blood vessels (HP:0007843)2.42182303
37Petechiae (HP:0000967)2.42134176
38Respiratory failure (HP:0002878)2.40417499
39Delayed CNS myelination (HP:0002188)2.37880908
40Increased hepatocellular lipid droplets (HP:0006565)2.37040532
41Abnormality of the prostate (HP:0008775)2.36614992
42CNS demyelination (HP:0007305)2.35569967
43Optic disc pallor (HP:0000543)2.35298451
44Hypothermia (HP:0002045)2.34553259
45IgG deficiency (HP:0004315)2.28143776
46Congenital, generalized hypertrichosis (HP:0004540)2.24282722
47Facial diplegia (HP:0001349)2.24155405
48Leukodystrophy (HP:0002415)2.23055869
49Lipid accumulation in hepatocytes (HP:0006561)2.22031594
50Intrahepatic cholestasis (HP:0001406)2.19511039
51Lethargy (HP:0001254)2.16767805
52Molar tooth sign on MRI (HP:0002419)2.13629973
53Abnormality of midbrain morphology (HP:0002418)2.13629973
54Increased muscle lipid content (HP:0009058)2.12375270
55Meckel diverticulum (HP:0002245)2.08315698
56Aplasia/hypoplasia of the uterus (HP:0008684)2.07958002
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05064683
58Abolished electroretinogram (ERG) (HP:0000550)2.05058525
59Abnormality of the renal cortex (HP:0011035)2.02843400
60Abnormality of the ileum (HP:0001549)2.02663070
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.01918544
62Constricted visual fields (HP:0001133)1.99779393
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97532331
64Testicular atrophy (HP:0000029)1.96897657
65Poor head control (HP:0002421)1.96138092
66Type 2 muscle fiber atrophy (HP:0003554)1.95161024
67Duplicated collecting system (HP:0000081)1.94835394
68Concave nail (HP:0001598)1.94580572
69Abnormality of the renal collecting system (HP:0004742)1.94359673
70Renal cortical cysts (HP:0000803)1.92849540
71Abnormality of T cell physiology (HP:0011840)1.92070964
72Prostate neoplasm (HP:0100787)1.91011767
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89102298
74Progressive inability to walk (HP:0002505)1.88815545
75Microvesicular hepatic steatosis (HP:0001414)1.87496107
76Exertional dyspnea (HP:0002875)1.87415110
77Skin rash (HP:0000988)1.86443305
78Clubbing of toes (HP:0100760)1.85760240
79Methylmalonic acidemia (HP:0002912)1.85361002
80Amyloidosis (HP:0011034)1.85068229
81Methylmalonic aciduria (HP:0012120)1.84315227
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83842023
83Hypoplasia of the uterus (HP:0000013)1.83786255
84Arthropathy (HP:0003040)1.81633940
85Stomach cancer (HP:0012126)1.80475162
86Pancreatic cysts (HP:0001737)1.79969585
87Autoimmune hemolytic anemia (HP:0001890)1.79617043
88Palpitations (HP:0001962)1.78206841
89Nephronophthisis (HP:0000090)1.76680422
90Congenital stationary night blindness (HP:0007642)1.72593351
91Abnormal biliary tract physiology (HP:0012439)1.71696379
92Bile duct proliferation (HP:0001408)1.71696379
93Abnormality of the renal medulla (HP:0100957)1.71010541
94Abnormality of urine glucose concentration (HP:0011016)1.70354858
95Glycosuria (HP:0003076)1.70354858
96Keratoconus (HP:0000563)1.69932985
97Increased corneal curvature (HP:0100692)1.69932985
98Abnormality of the preputium (HP:0100587)1.68978432
99Abnormality of pyrimidine metabolism (HP:0004353)1.68677400
100Abnormality of methionine metabolism (HP:0010901)1.68131546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.00615396
2EIF2AK13.95166477
3BCKDK2.81491608
4TSSK62.60178482
5NUAK12.57510223
6PDK22.50604908
7TLK12.49369621
8ZAK2.44705435
9VRK22.43465483
10GRK12.39345757
11FRK2.12392990
12FER2.06617916
13EIF2AK32.03671095
14TAOK31.99433128
15TEC1.98324633
16ADRBK21.89023929
17ITK1.81473221
18FES1.78714222
19KIT1.77991122
20NEK91.66756129
21PLK21.62357667
22MAP3K121.61722862
23FLT31.55034857
24NME11.44280529
25PINK11.41562384
26PHKG11.39551416
27PHKG21.39551416
28KDR1.37996049
29OXSR11.35910739
30MAP4K21.34666932
31PLK31.33640310
32STK161.30832917
33LMTK21.26594517
34TXK1.22359798
35CDK191.18413498
36PRKCE1.14605874
37MYLK1.11908154
38TAF11.11026222
39SRPK11.10378999
40SYK1.08882617
41ZAP701.03063520
42STK391.01135930
43WNK40.92135348
44ALK0.91971416
45TIE10.90321891
46WNK30.86654443
47MAP2K60.84691328
48VRK10.82295915
49GRK60.81279923
50IKBKE0.80716933
51BMPR20.79152193
52STK38L0.76482119
53INSRR0.76352516
54IKBKB0.75714656
55PIM20.73044871
56GRK50.72416524
57BUB10.71141337
58PRKCI0.71079066
59DYRK20.70624456
60DAPK10.68136470
61CSNK1G30.67202913
62NEK10.65575828
63MAPKAPK30.64886707
64CCNB10.64385062
65PAK40.63099028
66STK240.61796049
67CSNK1A10.61163613
68BMPR1B0.59651877
69LYN0.59218669
70ERBB30.56314121
71CSNK1G10.50777569
72EIF2AK20.50434835
73PIM10.50108783
74ATR0.48485344
75CDK80.48210739
76CSNK1G20.47260443
77CSF1R0.45796762
78CSNK1A1L0.45456662
79PLK10.45332453
80DAPK20.44505990
81ADRBK10.43688992
82ILK0.43675603
83PRKCA0.43603789
84PLK40.42404213
85PTK2B0.40113872
86PRKACA0.38562575
87CSNK2A10.37322281
88LCK0.37133596
89ABL20.36130095
90RPS6KA50.35635481
91IGF1R0.34551109
92JAK30.32590010
93PRKG20.31222628
94MAPKAPK50.30650420
95ACVR1B0.29478172
96PRKCG0.28724254
97OBSCN0.28658835
98MAP4K10.28541241
99MAPK130.27929237
100CAMK2A0.27645590

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.25732120
2Asthma_Homo sapiens_hsa053103.83479708
3Allograft rejection_Homo sapiens_hsa053303.55812774
4Autoimmune thyroid disease_Homo sapiens_hsa053203.34919122
5Graft-versus-host disease_Homo sapiens_hsa053323.16248681
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.12255698
7Type I diabetes mellitus_Homo sapiens_hsa049402.99140491
8Protein export_Homo sapiens_hsa030602.55371547
9Oxidative phosphorylation_Homo sapiens_hsa001902.39865275
10Parkinsons disease_Homo sapiens_hsa050122.16053277
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92447512
12Sulfur metabolism_Homo sapiens_hsa009201.89565308
13RNA polymerase_Homo sapiens_hsa030201.73862999
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72634385
15Vitamin digestion and absorption_Homo sapiens_hsa049771.67197178
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47829016
17Nitrogen metabolism_Homo sapiens_hsa009101.44769906
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.44266019
19Antigen processing and presentation_Homo sapiens_hsa046121.43873302
20Rheumatoid arthritis_Homo sapiens_hsa053231.34128441
21RNA degradation_Homo sapiens_hsa030181.33150841
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32169021
23Caffeine metabolism_Homo sapiens_hsa002321.28928831
24Nucleotide excision repair_Homo sapiens_hsa034201.27186522
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27048600
26Huntingtons disease_Homo sapiens_hsa050161.24231797
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20420223
28Fat digestion and absorption_Homo sapiens_hsa049751.18706605
29Staphylococcus aureus infection_Homo sapiens_hsa051501.17906022
30Homologous recombination_Homo sapiens_hsa034401.15054594
31Alzheimers disease_Homo sapiens_hsa050101.14160445
32Linoleic acid metabolism_Homo sapiens_hsa005911.13393063
33One carbon pool by folate_Homo sapiens_hsa006701.08218883
34Hematopoietic cell lineage_Homo sapiens_hsa046401.02637542
35Basal transcription factors_Homo sapiens_hsa030221.02545079
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99941196
37Fatty acid elongation_Homo sapiens_hsa000620.99602492
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98297298
39Propanoate metabolism_Homo sapiens_hsa006400.98025427
40Viral myocarditis_Homo sapiens_hsa054160.97163100
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96432822
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95406736
43Mismatch repair_Homo sapiens_hsa034300.94052389
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91696703
45Base excision repair_Homo sapiens_hsa034100.90559081
46Pyruvate metabolism_Homo sapiens_hsa006200.88712922
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87291840
48Primary immunodeficiency_Homo sapiens_hsa053400.87240647
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.85779297
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82546910
51Fanconi anemia pathway_Homo sapiens_hsa034600.82514276
52Peroxisome_Homo sapiens_hsa041460.81782733
53Fatty acid degradation_Homo sapiens_hsa000710.81495950
54Systemic lupus erythematosus_Homo sapiens_hsa053220.80660670
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80270033
56Cardiac muscle contraction_Homo sapiens_hsa042600.79753641
57Arachidonic acid metabolism_Homo sapiens_hsa005900.79426030
58DNA replication_Homo sapiens_hsa030300.78867452
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78606328
60Ribosome_Homo sapiens_hsa030100.78201779
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78164685
62Tryptophan metabolism_Homo sapiens_hsa003800.77869267
63N-Glycan biosynthesis_Homo sapiens_hsa005100.76576362
64Pyrimidine metabolism_Homo sapiens_hsa002400.76434476
65Chemical carcinogenesis_Homo sapiens_hsa052040.75609024
66RNA transport_Homo sapiens_hsa030130.72914762
67Purine metabolism_Homo sapiens_hsa002300.71983245
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71939343
69beta-Alanine metabolism_Homo sapiens_hsa004100.71371316
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68537672
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66334037
72Glutathione metabolism_Homo sapiens_hsa004800.65597122
73Butanoate metabolism_Homo sapiens_hsa006500.65096365
74Retinol metabolism_Homo sapiens_hsa008300.64776201
75Non-homologous end-joining_Homo sapiens_hsa034500.60915735
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60536875
77Phototransduction_Homo sapiens_hsa047440.59411687
78Glycerolipid metabolism_Homo sapiens_hsa005610.59153063
79Metabolic pathways_Homo sapiens_hsa011000.57265231
80Ether lipid metabolism_Homo sapiens_hsa005650.54576557
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54263741
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.54163356
83Arginine and proline metabolism_Homo sapiens_hsa003300.51664082
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.51113151
85Steroid biosynthesis_Homo sapiens_hsa001000.50774969
86Folate biosynthesis_Homo sapiens_hsa007900.50599535
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50116480
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48691496
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47044133
90Spliceosome_Homo sapiens_hsa030400.46851413
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46846860
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43656924
93ABC transporters_Homo sapiens_hsa020100.43123957
94Collecting duct acid secretion_Homo sapiens_hsa049660.40186286
95Fatty acid metabolism_Homo sapiens_hsa012120.39056248
96Arginine biosynthesis_Homo sapiens_hsa002200.39001050
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38082743
98Regulation of autophagy_Homo sapiens_hsa041400.36015219
99Histidine metabolism_Homo sapiens_hsa003400.35837283
100Leishmaniasis_Homo sapiens_hsa051400.35026157

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