EIF3CL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)6.02720277
2establishment of viral latency (GO:0019043)4.77791201
3ribosomal small subunit biogenesis (GO:0042274)4.75734309
4* formation of translation preinitiation complex (GO:0001731)4.49732044
5ribosome assembly (GO:0042255)4.49294860
6maturation of SSU-rRNA (GO:0030490)4.46019584
7DNA unwinding involved in DNA replication (GO:0006268)4.34974872
8DNA strand elongation involved in DNA replication (GO:0006271)4.12001891
9mitotic metaphase plate congression (GO:0007080)4.09383930
10DNA replication checkpoint (GO:0000076)4.07860390
11viral transcription (GO:0019083)4.05568734
12ribosomal large subunit biogenesis (GO:0042273)4.04548063
13DNA strand elongation (GO:0022616)3.96571278
14translational termination (GO:0006415)3.94127958
15CENP-A containing nucleosome assembly (GO:0034080)3.91266966
16regulation of transcription from RNA polymerase I promoter (GO:0006356)3.89817525
17chromatin remodeling at centromere (GO:0031055)3.89368249
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.88209962
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.86559085
20spliceosomal snRNP assembly (GO:0000387)3.82582183
21protein localization to kinetochore (GO:0034501)3.80538136
22ribonucleoprotein complex biogenesis (GO:0022613)3.79620377
23heterochromatin organization (GO:0070828)3.65949909
24translational initiation (GO:0006413)3.65801301
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65241694
26mitotic chromosome condensation (GO:0007076)3.64750908
27protein targeting to ER (GO:0045047)3.61999805
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.61297691
29DNA replication-independent nucleosome organization (GO:0034724)3.60528018
30DNA replication-independent nucleosome assembly (GO:0006336)3.60528018
31cotranslational protein targeting to membrane (GO:0006613)3.59966199
32chaperone-mediated protein transport (GO:0072321)3.56075141
33telomere maintenance via semi-conservative replication (GO:0032201)3.52970353
34ribosomal small subunit assembly (GO:0000028)3.52049661
35DNA damage response, detection of DNA damage (GO:0042769)3.51644722
36IMP biosynthetic process (GO:0006188)3.50727904
37translational elongation (GO:0006414)3.50592385
38mRNA splicing, via spliceosome (GO:0000398)3.49635681
39RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.49635681
40DNA replication-dependent nucleosome assembly (GO:0006335)3.49591634
41DNA replication-dependent nucleosome organization (GO:0034723)3.49591634
42regulation of mitochondrial translation (GO:0070129)3.49266218
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47709199
44ribosome biogenesis (GO:0042254)3.46300448
45histone exchange (GO:0043486)3.45822093
46RNA splicing, via transesterification reactions (GO:0000375)3.45392821
47DNA topological change (GO:0006265)3.42989679
48DNA ligation (GO:0006266)3.42103093
49regulation of translational termination (GO:0006449)3.41998989
50purine nucleobase biosynthetic process (GO:0009113)3.41902392
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.39624021
52termination of RNA polymerase III transcription (GO:0006386)3.39624021
53metaphase plate congression (GO:0051310)3.38228112
54IMP metabolic process (GO:0046040)3.37083125
55protein localization to endoplasmic reticulum (GO:0070972)3.35161332
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34261170
57translation (GO:0006412)3.32809987
58rRNA processing (GO:0006364)3.31666977
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31550918
60proteasome assembly (GO:0043248)3.31385486
61ATP-dependent chromatin remodeling (GO:0043044)3.30186117
62protein complex localization (GO:0031503)3.27768667
63nucleobase biosynthetic process (GO:0046112)3.27029479
64protein localization to chromosome, centromeric region (GO:0071459)3.21992271
65mitotic sister chromatid segregation (GO:0000070)3.18736373
66negative regulation of ligase activity (GO:0051352)3.16721358
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16721358
68negative regulation of RNA splicing (GO:0033119)3.16085702
69viral life cycle (GO:0019058)3.15875167
70mitotic sister chromatid cohesion (GO:0007064)3.14933607
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14313856
72negative regulation of mRNA metabolic process (GO:1903312)3.14259210
73rRNA metabolic process (GO:0016072)3.13492931
74kinetochore organization (GO:0051383)3.10283535
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07997757
76ATP synthesis coupled proton transport (GO:0015986)3.07997757
777-methylguanosine mRNA capping (GO:0006370)3.05647278
78chromatin assembly or disassembly (GO:0006333)3.05401973
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05258917
80cellular protein complex disassembly (GO:0043624)3.04973979
81cellular component biogenesis (GO:0044085)3.01467810
82transcription-coupled nucleotide-excision repair (GO:0006283)3.01248025
83DNA replication initiation (GO:0006270)3.01082801
84termination of RNA polymerase II transcription (GO:0006369)3.00170056
857-methylguanosine RNA capping (GO:0009452)2.96150517
86RNA capping (GO:0036260)2.96150517
87regulation of translational fidelity (GO:0006450)2.93876497
88rRNA modification (GO:0000154)2.93775290
89transcription from mitochondrial promoter (GO:0006390)2.93420213
90negative regulation of mRNA processing (GO:0050686)2.93159717
91sister chromatid segregation (GO:0000819)2.92062099
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91296127
93mitotic recombination (GO:0006312)2.90287544
94protein targeting to mitochondrion (GO:0006626)2.89679060
95protein complex disassembly (GO:0043241)2.89016011
96alternative mRNA splicing, via spliceosome (GO:0000380)2.88226597
97telomere maintenance via recombination (GO:0000722)2.87603060
98* ribonucleoprotein complex assembly (GO:0022618)2.85082249
99nucleobase-containing small molecule interconversion (GO:0015949)2.82846105
100establishment of chromosome localization (GO:0051303)2.81286811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.33490598
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.55316363
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04491994
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.82917422
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61492945
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.61114051
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44530587
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34191403
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.33544818
10MYC_19030024_ChIP-ChIP_MESCs_Mouse3.18066525
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10103422
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99279417
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97306192
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.94227942
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.92872008
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83762617
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.63661689
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.58196553
19XRN2_22483619_ChIP-Seq_HELA_Human2.55774566
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.45531641
21AR_21909140_ChIP-Seq_LNCAP_Human2.23373280
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20272104
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18866424
24TTF2_22483619_ChIP-Seq_HELA_Human2.17417862
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.11196662
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.10032097
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.08826049
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05643290
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04706548
30DCP1A_22483619_ChIP-Seq_HELA_Human2.00213782
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93988771
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.91891280
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.90610292
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90449205
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86590070
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82960616
37FOXP3_21729870_ChIP-Seq_TREG_Human1.78920965
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74942392
39GABP_19822575_ChIP-Seq_HepG2_Human1.72563700
40VDR_23849224_ChIP-Seq_CD4+_Human1.67325686
41ELK1_19687146_ChIP-ChIP_HELA_Human1.66497963
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62515721
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.62319523
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60061878
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52506132
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51265669
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50058708
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49760815
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49109122
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46423179
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45137459
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40211697
53MYC_22102868_ChIP-Seq_BL_Human1.39923118
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38537560
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36591110
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36313721
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35249769
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33475492
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31545398
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.31117143
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30628070
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.29519928
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26981272
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26541423
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24381784
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24239423
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24075187
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23366818
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21880709
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.21400891
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20547499
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20202185
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17210389
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14418549
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.14114030
76KDM5A_27292631_Chip-Seq_BREAST_Human1.11954706
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10984027
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06787096
79SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06038506
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03616260
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03039312
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.02803483
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02678217
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02571002
85ZNF263_19887448_ChIP-Seq_K562_Human1.01697927
86OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01593343
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01195509
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00361038
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00004112
90CLOCK_20551151_ChIP-Seq_293T_Human0.99208015
91CHD1_26751641_Chip-Seq_LNCaP_Human0.98643649
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98014950
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96642799
94MYC_18940864_ChIP-ChIP_HL60_Human0.95773448
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95287517
96CIITA_25753668_ChIP-Seq_RAJI_Human0.95061218
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94837022
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94739710
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91658614
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88482242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.78478237
2MP0004957_abnormal_blastocyst_morpholog4.57574632
3MP0010094_abnormal_chromosome_stability3.95647300
4MP0003111_abnormal_nucleus_morphology3.92175376
5MP0003077_abnormal_cell_cycle3.31090942
6MP0008058_abnormal_DNA_repair3.06565673
7MP0009379_abnormal_foot_pigmentation2.91239466
8MP0002877_abnormal_melanocyte_morpholog2.83063181
9MP0010030_abnormal_orbit_morphology2.82597020
10MP0008932_abnormal_embryonic_tissue2.81374522
11MP0001730_embryonic_growth_arrest2.69671988
12MP0000350_abnormal_cell_proliferation2.28343667
13MP0003941_abnormal_skin_development2.27632228
14MP0000537_abnormal_urethra_morphology2.26492063
15MP0009672_abnormal_birth_weight2.21700669
16MP0001293_anophthalmia2.11178998
17MP0008007_abnormal_cellular_replicative2.01447431
18MP0004272_abnormal_basement_membrane1.92886923
19MP0002085_abnormal_embryonic_tissue1.92108468
20MP0005380_embryogenesis_phenotype1.86630570
21MP0001672_abnormal_embryogenesis/_devel1.86630570
22MP0003123_paternal_imprinting1.82332930
23MP0001697_abnormal_embryo_size1.81806706
24MP0002697_abnormal_eye_size1.78105138
25MP0003984_embryonic_growth_retardation1.74941562
26MP0003567_abnormal_fetal_cardiomyocyte1.69837883
27MP0002080_prenatal_lethality1.69131319
28MP0002088_abnormal_embryonic_growth/wei1.69119682
29MP0008057_abnormal_DNA_replication1.67355014
30MP0002084_abnormal_developmental_patter1.67044656
31MP0006292_abnormal_olfactory_placode1.63118105
32MP0001188_hyperpigmentation1.62172864
33MP0002254_reproductive_system_inflammat1.60770234
34MP0010352_gastrointestinal_tract_polyps1.55821283
35MP0003937_abnormal_limbs/digits/tail_de1.55244993
36MP0003718_maternal_effect1.53363822
37MP0000490_abnormal_crypts_of1.45617639
38MP0002796_impaired_skin_barrier1.42931594
39MP0003806_abnormal_nucleotide_metabolis1.41294488
40MP0005501_abnormal_skin_physiology1.39982248
41MP0000313_abnormal_cell_death1.39862658
42MP0003315_abnormal_perineum_morphology1.38645821
43MP0002938_white_spotting1.38064402
44MP0010234_abnormal_vibrissa_follicle1.38020830
45MP0003119_abnormal_digestive_system1.35123489
46MP0004197_abnormal_fetal_growth/weight/1.32681388
47MP0002111_abnormal_tail_morphology1.30994995
48MP0002086_abnormal_extraembryonic_tissu1.28657414
49MP0001286_abnormal_eye_development1.21392942
50MP0004185_abnormal_adipocyte_glucose1.19988505
51MP0003186_abnormal_redox_activity1.19328557
52MP0003890_abnormal_embryonic-extraembry1.16120917
53MP0001299_abnormal_eye_distance/1.14885494
54MP0003705_abnormal_hypodermis_morpholog1.14192895
55MP0002092_abnormal_eye_morphology1.13965650
56MP0009703_decreased_birth_body1.13412165
57MP0000358_abnormal_cell_content/1.10570147
58MP0005623_abnormal_meninges_morphology1.10236960
59MP0000049_abnormal_middle_ear1.09885760
60MP0000566_synostosis1.09556525
61MP0003938_abnormal_ear_development1.09282608
62MP0003786_premature_aging1.03358139
63MP0005076_abnormal_cell_differentiation1.03223644
64MP0001346_abnormal_lacrimal_gland1.02670693
65MP0010307_abnormal_tumor_latency0.99048551
66MP0001849_ear_inflammation0.97828310
67MP0006035_abnormal_mitochondrial_morpho0.93024332
68MP0002233_abnormal_nose_morphology0.91572562
69MP0003861_abnormal_nervous_system0.90894137
70MP0000428_abnormal_craniofacial_morphol0.90095240
71MP0001727_abnormal_embryo_implantation0.89701647
72MP0001915_intracranial_hemorrhage0.87807492
73MP0003221_abnormal_cardiomyocyte_apopto0.85996094
74MP0003385_abnormal_body_wall0.85955923
75MP0001879_abnormal_lymphatic_vessel0.83682041
76MP0006036_abnormal_mitochondrial_physio0.83311556
77MP0004264_abnormal_extraembryonic_tissu0.78179854
78MP0002396_abnormal_hematopoietic_system0.78036393
79MP0002089_abnormal_postnatal_growth/wei0.77665609
80MP0000462_abnormal_digestive_system0.77051719
81MP0009697_abnormal_copulation0.76048417
82MP0003942_abnormal_urinary_system0.75074144
83MP0003935_abnormal_craniofacial_develop0.74848389
84MP0003115_abnormal_respiratory_system0.73785536
85MP0000432_abnormal_head_morphology0.73396068
86MP0002081_perinatal_lethality0.71805863
87MP0003121_genomic_imprinting0.71028081
88MP0000747_muscle_weakness0.70663824
89MP0000762_abnormal_tongue_morphology0.68593675
90MP0005384_cellular_phenotype0.68551279
91MP0002751_abnormal_autonomic_nervous0.65801672
92MP0005330_cardiomyopathy0.65591328
93MP0005248_abnormal_Harderian_gland0.65091736
94MP0004233_abnormal_muscle_weight0.63352217
95MP0003755_abnormal_palate_morphology0.63350900
96MP0002116_abnormal_craniofacial_bone0.62778526
97MP0009053_abnormal_anal_canal0.60984970
98MP0001881_abnormal_mammary_gland0.60841872
99MP0010630_abnormal_cardiac_muscle0.60280860
100MP0002019_abnormal_tumor_incidence0.59113781

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.77777487
2Macrocytic anemia (HP:0001972)3.70386936
3Aplasia/Hypoplasia of the sacrum (HP:0008517)3.47786754
4Increased hepatocellular lipid droplets (HP:0006565)3.45577651
5Multiple enchondromatosis (HP:0005701)3.44532993
6Acute necrotizing encephalopathy (HP:0006965)3.43657869
7Abnormality of cells of the erythroid lineage (HP:0012130)3.17533188
8Abnormal mitochondria in muscle tissue (HP:0008316)3.12158359
9Colon cancer (HP:0003003)2.99754991
10Acute encephalopathy (HP:0006846)2.97677926
11Increased nuchal translucency (HP:0010880)2.96627052
12Abnormal number of erythroid precursors (HP:0012131)2.95652532
13Lipid accumulation in hepatocytes (HP:0006561)2.89059300
14Spastic diplegia (HP:0001264)2.79339744
15Mitochondrial inheritance (HP:0001427)2.71003318
16Limb-girdle muscle atrophy (HP:0003797)2.63971242
17Birth length less than 3rd percentile (HP:0003561)2.59832563
18Respiratory difficulties (HP:0002880)2.58862569
19Shoulder girdle muscle weakness (HP:0003547)2.56116179
20Increased CSF lactate (HP:0002490)2.53313738
21Progressive macrocephaly (HP:0004481)2.47420043
22Cerebral edema (HP:0002181)2.46952307
23Megaloblastic anemia (HP:0001889)2.45540628
24Cortical dysplasia (HP:0002539)2.43517875
25Increased intramyocellular lipid droplets (HP:0012240)2.39599376
26Renal Fanconi syndrome (HP:0001994)2.38395224
27Horseshoe kidney (HP:0000085)2.37446042
28Abnormality of methionine metabolism (HP:0010901)2.34774515
29Progressive muscle weakness (HP:0003323)2.34663248
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30247927
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30247927
32Abnormal number of incisors (HP:0011064)2.30154818
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26202202
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21726808
35Pelvic girdle muscle weakness (HP:0003749)2.20636705
36Overriding aorta (HP:0002623)2.18419795
37Breech presentation (HP:0001623)2.17706926
38Abnormal lung lobation (HP:0002101)2.17601955
39Chromsome breakage (HP:0040012)2.17424408
40Ependymoma (HP:0002888)2.16752327
41Abnormality of glycolysis (HP:0004366)2.16608847
42Meckel diverticulum (HP:0002245)2.15241228
43Degeneration of anterior horn cells (HP:0002398)2.11501135
44Abnormality of the anterior horn cell (HP:0006802)2.11501135
45Abnormality of the hip-girdle musculature (HP:0001445)2.10678485
46Abnormality of the musculature of the pelvis (HP:0001469)2.10678485
47Microvesicular hepatic steatosis (HP:0001414)2.09905372
48Leukodystrophy (HP:0002415)2.09598639
49Abnormality of the labia minora (HP:0012880)2.08618145
50Volvulus (HP:0002580)2.06562659
51Abnormality of homocysteine metabolism (HP:0010919)2.03889809
52Homocystinuria (HP:0002156)2.03889809
53Nonimmune hydrops fetalis (HP:0001790)2.03814833
54Trismus (HP:0000211)2.01203354
55Pallor (HP:0000980)2.00963877
56Neonatal short-limb short stature (HP:0008921)2.00839888
57Abnormality of the umbilical cord (HP:0010881)1.99981581
58Calcaneovalgus deformity (HP:0001848)1.96030210
59Facial cleft (HP:0002006)1.95647259
60Abnormality of the ileum (HP:0001549)1.95373159
61Nephroblastoma (Wilms tumor) (HP:0002667)1.94922765
62Increased muscle lipid content (HP:0009058)1.91698758
63Proximal placement of thumb (HP:0009623)1.90105613
64Exertional dyspnea (HP:0002875)1.89205222
65Rough bone trabeculation (HP:0100670)1.89115016
66Hepatocellular necrosis (HP:0001404)1.87126065
67Exercise intolerance (HP:0003546)1.87011229
68Increased serum pyruvate (HP:0003542)1.86616098
69Hyperacusis (HP:0010780)1.86361275
70Absent radius (HP:0003974)1.84594523
71Abnormality of serum amino acid levels (HP:0003112)1.83692281
72Neoplasm of the colon (HP:0100273)1.83403738
73Methylmalonic acidemia (HP:0002912)1.82588398
74Atresia of the external auditory canal (HP:0000413)1.82013757
75Respiratory failure (HP:0002878)1.81602677
76Abnormalities of placenta or umbilical cord (HP:0001194)1.81489028
77Abnormality of the preputium (HP:0100587)1.81118572
78Embryonal renal neoplasm (HP:0011794)1.80122802
79Patent foramen ovale (HP:0001655)1.79927220
80Coarctation of aorta (HP:0001680)1.78811550
81Abnormality of placental membranes (HP:0011409)1.78640562
82Amniotic constriction ring (HP:0009775)1.78640562
83Partial duplication of thumb phalanx (HP:0009944)1.78400846
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77946983
85Partial duplication of the phalanx of hand (HP:0009999)1.77821363
86Cholecystitis (HP:0001082)1.76792855
87Abnormal gallbladder physiology (HP:0012438)1.76792855
88Absent forearm bone (HP:0003953)1.76680315
89Aplasia involving forearm bones (HP:0009822)1.76680315
90Deformed tarsal bones (HP:0008119)1.75629178
91Lactic acidosis (HP:0003128)1.74138393
92Methylmalonic aciduria (HP:0012120)1.71722117
93Neoplasm of the pancreas (HP:0002894)1.70918012
94Abnormality of chromosome stability (HP:0003220)1.70344214
95Medulloblastoma (HP:0002885)1.69472803
96Abnormality of the fetal cardiovascular system (HP:0010948)1.68893652
97Abnormal umbilical cord blood vessels (HP:0011403)1.68893652
98Single umbilical artery (HP:0001195)1.68893652
99Biliary tract neoplasm (HP:0100574)1.68815873
100Type I transferrin isoform profile (HP:0003642)1.68278395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.33656746
2CDC74.07753782
3BUB13.88759935
4TNIK3.49853382
5CDK123.47434846
6SRPK13.43383126
7TTK2.64527908
8MKNK22.58250654
9STK162.53871990
10TSSK62.45578306
11TAF12.39100620
12MKNK12.32302974
13VRK12.26913014
14NME22.25659517
15SMG12.19281022
16PLK32.16440787
17RPS6KA42.02294262
18NEK11.92263307
19ZAK1.89511656
20MAP3K101.83904372
21TLK11.82298411
22PBK1.82111161
23ALK1.77355670
24PLK41.59827351
25RPS6KB21.51529607
26BRD41.48763083
27NEK21.41189852
28NME11.33374837
29PLK11.30366252
30LATS21.28424705
31MST41.27964328
32PAK41.23368411
33EIF2AK11.21465809
34CHEK21.15543489
35AURKB1.13116677
36CDK71.12264331
37STK41.11894956
38STK241.07169303
39CHEK11.06472983
40TRIB31.05376759
41ATR1.02951109
42KDR0.96993759
43WEE10.91150192
44MUSK0.90489580
45AURKA0.88565405
46PASK0.86954269
47PNCK0.86484589
48DYRK30.81889927
49TRIM280.72495661
50EPHA20.72356705
51PKN20.70652584
52CDK40.67720294
53CSNK2A20.66769150
54MAP3K80.66597218
55BRSK10.64775848
56CDK190.63791907
57EPHB20.63623622
58ATM0.61149061
59CSNK1E0.59726474
60CDK90.59083692
61PDK20.58780083
62CDK20.56707953
63RPS6KA50.55620864
64BRAF0.55315192
65CSNK2A10.54956958
66ILK0.54381639
67CDK10.52792622
68CDK11A0.52189631
69FGFR10.52159842
70MOS0.49412512
71EIF2AK20.49016760
72ARAF0.48608048
73DYRK20.46907499
74CDK60.46740666
75DMPK0.46654402
76NUAK10.45878100
77CDK180.41345101
78CDK150.41273494
79PRKDC0.40109508
80PAK20.39025989
81EIF2AK30.38629721
82AKT20.38088609
83PTK60.37437712
84STK30.36619692
85MAP2K20.36252117
86DAPK30.35696959
87NTRK10.33688803
88BCKDK0.33569894
89CDK140.33523301
90CDK30.32414038
91BRSK20.30354033
92CLK10.29374124
93ABL20.28506877
94DAPK10.28360384
95MTOR0.27371663
96CSNK1G20.27292847
97STK100.27275318
98CSNK1G10.25836802
99SCYL20.24795421
100ERBB40.23227193

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.30792225
2DNA replication_Homo sapiens_hsa030304.14277611
3Proteasome_Homo sapiens_hsa030503.79573533
4Mismatch repair_Homo sapiens_hsa034303.65137579
5Spliceosome_Homo sapiens_hsa030403.47256645
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23797468
7RNA polymerase_Homo sapiens_hsa030203.00771787
8Base excision repair_Homo sapiens_hsa034102.52231418
9* RNA transport_Homo sapiens_hsa030132.47906151
10Oxidative phosphorylation_Homo sapiens_hsa001902.35963715
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22185890
12Protein export_Homo sapiens_hsa030602.16577921
13Parkinsons disease_Homo sapiens_hsa050122.13765584
14Non-homologous end-joining_Homo sapiens_hsa034502.07056659
15Homologous recombination_Homo sapiens_hsa034402.04811096
16Nucleotide excision repair_Homo sapiens_hsa034201.97603559
17Cell cycle_Homo sapiens_hsa041101.94687072
18RNA degradation_Homo sapiens_hsa030181.89690443
19Huntingtons disease_Homo sapiens_hsa050161.85961342
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83967011
21Pyrimidine metabolism_Homo sapiens_hsa002401.77857251
22One carbon pool by folate_Homo sapiens_hsa006701.74117638
23mRNA surveillance pathway_Homo sapiens_hsa030151.72095613
24Biosynthesis of amino acids_Homo sapiens_hsa012301.55329386
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54727687
26Basal transcription factors_Homo sapiens_hsa030221.51288926
27Alzheimers disease_Homo sapiens_hsa050101.35795871
28Sulfur relay system_Homo sapiens_hsa041221.29515704
29Pyruvate metabolism_Homo sapiens_hsa006201.24330787
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.23983432
31Carbon metabolism_Homo sapiens_hsa012001.22011641
32Vitamin B6 metabolism_Homo sapiens_hsa007501.21084177
33Folate biosynthesis_Homo sapiens_hsa007901.19733019
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18850664
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18433834
36Purine metabolism_Homo sapiens_hsa002301.18187451
37Fanconi anemia pathway_Homo sapiens_hsa034601.17961065
38Glutathione metabolism_Homo sapiens_hsa004801.07486338
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04940215
40Pentose phosphate pathway_Homo sapiens_hsa000301.03644293
41Systemic lupus erythematosus_Homo sapiens_hsa053220.98227990
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97997745
43Selenocompound metabolism_Homo sapiens_hsa004500.96165502
44Thyroid cancer_Homo sapiens_hsa052160.95258240
45Fructose and mannose metabolism_Homo sapiens_hsa000510.94509224
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87056778
47Epstein-Barr virus infection_Homo sapiens_hsa051690.86804239
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77939321
49Cardiac muscle contraction_Homo sapiens_hsa042600.77537044
50Tight junction_Homo sapiens_hsa045300.75342947
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.74634677
52Adherens junction_Homo sapiens_hsa045200.74407402
53Galactose metabolism_Homo sapiens_hsa000520.73713687
54Fatty acid elongation_Homo sapiens_hsa000620.73478504
55Basal cell carcinoma_Homo sapiens_hsa052170.71829925
56Vitamin digestion and absorption_Homo sapiens_hsa049770.71308502
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70807505
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67149694
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66175434
60Wnt signaling pathway_Homo sapiens_hsa043100.62105695
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.61922244
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58247259
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57210030
64Oocyte meiosis_Homo sapiens_hsa041140.56891855
65Alcoholism_Homo sapiens_hsa050340.54986608
66p53 signaling pathway_Homo sapiens_hsa041150.54100528
67Hedgehog signaling pathway_Homo sapiens_hsa043400.51073052
68Steroid biosynthesis_Homo sapiens_hsa001000.50084735
69Viral carcinogenesis_Homo sapiens_hsa052030.49429458
70Colorectal cancer_Homo sapiens_hsa052100.45766973
71Hippo signaling pathway_Homo sapiens_hsa043900.45226527
72Propanoate metabolism_Homo sapiens_hsa006400.43489386
73Arginine and proline metabolism_Homo sapiens_hsa003300.42707702
74Metabolic pathways_Homo sapiens_hsa011000.42127758
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38843093
76Bladder cancer_Homo sapiens_hsa052190.36515841
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34871220
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32599048
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31721006
80MicroRNAs in cancer_Homo sapiens_hsa052060.31715370
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31599686
82N-Glycan biosynthesis_Homo sapiens_hsa005100.29956489
83HTLV-I infection_Homo sapiens_hsa051660.29636184
84Vibrio cholerae infection_Homo sapiens_hsa051100.29603213
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29340166
86Lysine degradation_Homo sapiens_hsa003100.28486628
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27616413
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27576541
89TGF-beta signaling pathway_Homo sapiens_hsa043500.27499730
90Renin-angiotensin system_Homo sapiens_hsa046140.27436399
91Sulfur metabolism_Homo sapiens_hsa009200.24126641
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22790943
93HIF-1 signaling pathway_Homo sapiens_hsa040660.19905257
94Prostate cancer_Homo sapiens_hsa052150.19201856
95Herpes simplex infection_Homo sapiens_hsa051680.18271928
96Protein digestion and absorption_Homo sapiens_hsa049740.15202670
97Shigellosis_Homo sapiens_hsa051310.14006035
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.10439557
99Renal cell carcinoma_Homo sapiens_hsa052110.08376689
100Pathways in cancer_Homo sapiens_hsa052000.07656247

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