EIF2S2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)9.84767909
2negative regulation of type 2 immune response (GO:0002829)9.76731374
3seminiferous tubule development (GO:0072520)9.67648236
4activation of protein kinase A activity (GO:0034199)9.61028161
5positive regulation of RNA splicing (GO:0033120)9.44023689
6regulation of T-helper 2 cell differentiation (GO:0045628)9.33772265
7negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)8.51967965
8cAMP biosynthetic process (GO:0006171)8.41377784
9detection of chemical stimulus involved in sensory perception (GO:0050907)8.39990712
10negative regulation of alpha-beta T cell differentiation (GO:0046639)7.80364088
11enteric nervous system development (GO:0048484)7.66342854
12regulation of protein sumoylation (GO:0033233)7.11303041
13positive regulation of mitochondrial fission (GO:0090141)6.94900812
14synaptic transmission, dopaminergic (GO:0001963)6.87479574
15righting reflex (GO:0060013)6.85861857
16dendritic spine morphogenesis (GO:0060997)6.55692936
17positive regulation of T-helper 1 type immune response (GO:0002827)6.38794657
18heterotypic cell-cell adhesion (GO:0034113)6.09794499
19detection of chemical stimulus (GO:0009593)5.98337423
20arachidonic acid secretion (GO:0050482)5.90480082
21icosanoid secretion (GO:0032309)5.90480082
22endothelial cell differentiation (GO:0045446)5.75121259
23phosphatidylinositol acyl-chain remodeling (GO:0036149)5.72628756
24hepatocyte apoptotic process (GO:0097284)5.47057012
25positive regulation of T-helper cell differentiation (GO:0045624)5.47037045
26phosphatidylserine acyl-chain remodeling (GO:0036150)5.39778741
27phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.35620977
28drug transmembrane transport (GO:0006855)5.14371108
29regulation of mitochondrial fission (GO:0090140)5.08375098
30icosanoid transport (GO:0071715)4.87733479
31fatty acid derivative transport (GO:1901571)4.87733479
32chemosensory behavior (GO:0007635)4.82520588
33neural tube formation (GO:0001841)4.66996662
34neuronal ion channel clustering (GO:0045161)4.60488511
35hyaluronan catabolic process (GO:0030214)4.53253606
36regulation of T-helper 1 type immune response (GO:0002825)4.51670760
37nephron epithelium morphogenesis (GO:0072088)4.51010915
38nephron tubule morphogenesis (GO:0072078)4.51010915
39energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.42129966
40ATP hydrolysis coupled proton transport (GO:0015991)4.42129966
41embryonic digestive tract morphogenesis (GO:0048557)4.41457823
42negative regulation of alpha-beta T cell activation (GO:0046636)4.35472140
43retina layer formation (GO:0010842)4.32741677
44vocalization behavior (GO:0071625)4.31042200
45cilium or flagellum-dependent cell motility (GO:0001539)4.30185753
46attachment of spindle microtubules to kinetochore (GO:0008608)4.20458524
47positive regulation of membrane potential (GO:0045838)4.12997310
48drug transport (GO:0015893)4.10440186
49cyclic purine nucleotide metabolic process (GO:0052652)4.07600159
50positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.06136768
51protein localization to synapse (GO:0035418)4.05815557
52response to dietary excess (GO:0002021)4.00287449
53cellular response to glucagon stimulus (GO:0071377)3.96288096
54mitochondrial fusion (GO:0008053)3.95849738
55regulation of cAMP-mediated signaling (GO:0043949)3.95038296
56cyclic nucleotide biosynthetic process (GO:0009190)3.94853969
57left/right axis specification (GO:0070986)3.91888553
58regulation of T-helper cell differentiation (GO:0045622)3.87436945
59cellular zinc ion homeostasis (GO:0006882)3.84709934
60water transport (GO:0006833)3.84460320
61regulation of type 2 immune response (GO:0002828)3.80488314
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.79272367
63negative regulation of actin filament bundle assembly (GO:0032232)3.77032563
64cAMP metabolic process (GO:0046058)3.72705687
65negative regulation of T cell differentiation (GO:0045581)3.66051090
66cellular response to ATP (GO:0071318)3.62107826
67positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.56724025
68dendritic spine organization (GO:0097061)3.53384455
69monoamine transport (GO:0015844)3.52648848
70positive regulation of protein targeting to membrane (GO:0090314)3.49575253
71negative regulation of cytosolic calcium ion concentration (GO:0051481)3.45616916
72sulfur amino acid catabolic process (GO:0000098)3.42815325
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.41366319
74fluid transport (GO:0042044)3.41316073
75positive regulation of dendritic spine development (GO:0060999)3.37558580
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37300165
77positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.30719344
78leukotriene biosynthetic process (GO:0019370)3.29193795
79pre-miRNA processing (GO:0031054)3.25002289
80phosphatidylcholine acyl-chain remodeling (GO:0036151)3.24767533
81neurofilament cytoskeleton organization (GO:0060052)3.21896085
82renal tubule morphogenesis (GO:0061333)3.20149732
83prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.15863774
84positive regulation of alpha-beta T cell differentiation (GO:0046638)3.15155941
85interleukin-6-mediated signaling pathway (GO:0070102)3.14186659
86negative regulation of homotypic cell-cell adhesion (GO:0034111)3.13304523
87sequestering of metal ion (GO:0051238)3.13273505
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12315093
89adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.11107709
90neuromuscular process controlling posture (GO:0050884)3.10589439
91positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06726421
92reflex (GO:0060004)3.05349563
93vitamin catabolic process (GO:0009111)3.04462058
94fat-soluble vitamin catabolic process (GO:0042363)3.04462058
95tooth mineralization (GO:0034505)13.9569670
96detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.5028564
97positive regulation of protein sumoylation (GO:0033235)11.4857792
98negative regulation of T-helper cell differentiation (GO:0045623)10.6891273
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)10.6891273
100protein K11-linked deubiquitination (GO:0035871)10.3170116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.62130110
2IGF1R_20145208_ChIP-Seq_DFB_Human4.89425719
3AR_21572438_ChIP-Seq_LNCaP_Human4.88453828
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.75187198
5VDR_22108803_ChIP-Seq_LS180_Human4.70345312
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.19837084
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27541447
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.27541447
9TP53_16413492_ChIP-PET_HCT116_Human2.06760767
10PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.02181803
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.8532511
12YY1_22570637_ChIP-Seq_MALME-3M_Human1.98968387
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97686310
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78595936
15ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74911119
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66973927
17NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58438497
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56409953
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54283216
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.53430755
21GATA1_19941826_ChIP-Seq_K562_Human1.53160290
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51899715
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50951694
24EGR1_19032775_ChIP-ChIP_M12_Human1.49393740
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.46057487
26EZH2_22144423_ChIP-Seq_EOC_Human1.43050261
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36628746
28SMAD3_21741376_ChIP-Seq_HESCs_Human1.33312437
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33073185
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31266223
31DROSHA_22980978_ChIP-Seq_HELA_Human1.30898886
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.30824717
33RNF2_27304074_Chip-Seq_NSC_Mouse1.30386938
34RXR_22108803_ChIP-Seq_LS180_Human1.24803637
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.24624072
36HNFA_21074721_ChIP-Seq_CACO-2_Human1.20865137
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18225648
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15735364
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14838291
40TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.14775558
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14490284
42GATA6_21074721_ChIP-Seq_CACO-2_Human1.13850839
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.12577173
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11388306
45PHF8_20622853_ChIP-Seq_HELA_Human1.09609925
46TBL1_22424771_ChIP-Seq_293T_Human1.09281388
47ER_23166858_ChIP-Seq_MCF-7_Human1.09102979
48TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07894787
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.06851808
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.05563956
51KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04672403
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.04210295
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03900746
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03500890
55BCAT_22108803_ChIP-Seq_LS180_Human1.02982651
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02005822
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01682232
58SOX2_18555785_Chip-Seq_ESCs_Mouse1.01388109
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99921388
60GBX2_23144817_ChIP-Seq_PC3_Human0.99397171
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97996064
62ZNF274_21170338_ChIP-Seq_K562_Hela0.97552641
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97248651
64STAT3_23295773_ChIP-Seq_U87_Human0.96786632
65PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96182711
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96157122
67ARNT_22903824_ChIP-Seq_MCF-7_Human0.95850651
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95409557
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95409557
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95409557
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95099297
72REST_21632747_ChIP-Seq_MESCs_Mouse0.92993920
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92644514
74CBP_20019798_ChIP-Seq_JUKART_Human0.92644514
75ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92104017
76SMAD4_21741376_ChIP-Seq_HESCs_Human0.91819260
77CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90981253
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.90770558
79CTCF_27219007_Chip-Seq_Bcells_Human0.90744828
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90388918
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89993453
82CMYC_18555785_Chip-Seq_ESCs_Mouse0.89205252
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89068366
84NANOG_20526341_ChIP-Seq_ESCs_Human0.88160326
85DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86505178
86NANOG_16518401_ChIP-PET_MESCs_Mouse0.86390064
87GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86385721
88REST_18959480_ChIP-ChIP_MESCs_Mouse0.86194634
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85579581
90ETV1_20927104_ChIP-Seq_GIST48_Human0.85317742
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84689642
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84045219
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.83682708
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82651207
95TCF4_22108803_ChIP-Seq_LS180_Human0.82009472
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81973155
97NFYB_21822215_ChIP-Seq_K562_Human0.81907610
98NMYC_18555785_Chip-Seq_ESCs_Mouse0.81706143
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81540674
100HTT_18923047_ChIP-ChIP_STHdh_Human0.81117021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.30758345
2MP0004130_abnormal_muscle_cell4.72653256
3MP0004264_abnormal_extraembryonic_tissu3.52877814
4MP0003252_abnormal_bile_duct3.46217175
5MP0004133_heterotaxia3.05706876
6MP0002928_abnormal_bile_duct2.65349333
7MP0006072_abnormal_retinal_apoptosis2.51880643
8MP0005408_hypopigmentation2.28236093
9MP0002751_abnormal_autonomic_nervous2.15274519
10MP0005448_abnormal_energy_balance2.09804785
11MP0005084_abnormal_gallbladder_morpholo12.3047697
12MP0004272_abnormal_basement_membrane1.84827450
13MP0003329_amyloid_beta_deposits1.83899796
14MP0001270_distended_abdomen1.81621126
15MP0005646_abnormal_pituitary_gland1.59839105
16MP0004019_abnormal_vitamin_homeostasis1.58597915
17MP0005379_endocrine/exocrine_gland_phen1.53270996
18MP0003943_abnormal_hepatobiliary_system1.48242334
19MP0003718_maternal_effect1.40275298
20MP0005220_abnormal_exocrine_pancreas1.40157351
21MP0001529_abnormal_vocalization1.39727500
22MP0002909_abnormal_adrenal_gland1.33779070
23MP0005165_increased_susceptibility_to1.29419651
24MP0008875_abnormal_xenobiotic_pharmacok1.25722074
25MP0009764_decreased_sensitivity_to1.20498397
26MP0000604_amyloidosis1.19758945
27MP0001542_abnormal_bone_strength1.19161187
28MP0002736_abnormal_nociception_after1.08406246
29MP0003195_calcinosis1.04046085
30MP0000470_abnormal_stomach_morphology1.03201225
31MP0001764_abnormal_homeostasis1.02794253
32MP0001958_emphysema1.01620321
33MP0002572_abnormal_emotion/affect_behav1.00340778
34MP0008569_lethality_at_weaning0.97171371
35MP0001905_abnormal_dopamine_level0.96926494
36MP0002396_abnormal_hematopoietic_system0.95661527
37MP0003638_abnormal_response/metabolism_0.95459258
38MP0003315_abnormal_perineum_morphology0.92893731
39MP0003121_genomic_imprinting0.86584389
40MP0001944_abnormal_pancreas_morphology0.85036586
41MP0004043_abnormal_pH_regulation0.84124986
42MP0000371_diluted_coat_color0.82795408
43MP0009053_abnormal_anal_canal0.78589893
44MP0008469_abnormal_protein_level0.78417716
45MP0002160_abnormal_reproductive_system0.73763088
46MP0001968_abnormal_touch/_nociception0.73137716
47MP0002234_abnormal_pharynx_morphology0.70512211
48MP0002837_dystrophic_cardiac_calcinosis0.68125039
49MP0005164_abnormal_response_to0.67343203
50MP0006292_abnormal_olfactory_placode0.66707182
51MP0002136_abnormal_kidney_physiology0.66373307
52MP0002098_abnormal_vibrissa_morphology0.64662994
53MP0000609_abnormal_liver_physiology0.64575254
54MP0002277_abnormal_respiratory_mucosa0.64380738
55MP0003953_abnormal_hormone_level0.64131494
56MP0005253_abnormal_eye_physiology0.61557491
57MP0002693_abnormal_pancreas_physiology0.60895920
58MP0002078_abnormal_glucose_homeostasis0.59154073
59MP0000703_abnormal_thymus_morphology0.59042395
60MP0005389_reproductive_system_phenotype0.55222319
61MP0001800_abnormal_humoral_immune0.53403497
62MP0005551_abnormal_eye_electrophysiolog0.52948421
63MP0005365_abnormal_bile_salt0.52782066
64MP0005376_homeostasis/metabolism_phenot0.51638661
65MP0001851_eye_inflammation0.48862378
66MP0003866_abnormal_defecation0.48168206
67MP0009642_abnormal_blood_homeostasis0.47843219
68MP0002405_respiratory_system_inflammati0.43834309
69MP0005423_abnormal_somatic_nervous0.43178485
70MP0005377_hearing/vestibular/ear_phenot0.42569955
71MP0003878_abnormal_ear_physiology0.42569955
72MP0001293_anophthalmia0.41282173
73MP0003879_abnormal_hair_cell0.40902645
74MP0001299_abnormal_eye_distance/0.40349667
75MP0005332_abnormal_amino_acid0.39281673
76MP0002089_abnormal_postnatal_growth/wei0.39012676
77MP0002139_abnormal_hepatobiliary_system0.38956971
78MP0001915_intracranial_hemorrhage0.38355114
79MP0005387_immune_system_phenotype0.38211250
80MP0001790_abnormal_immune_system0.38211250
81MP0003880_abnormal_central_pattern0.37763550
82MP0009931_abnormal_skin_appearance0.37666261
83MP0004885_abnormal_endolymph0.37142712
84MP0000465_gastrointestinal_hemorrhage0.36052226
85MP0002722_abnormal_immune_system0.35818379
86MP0006276_abnormal_autonomic_nervous0.35729917
87MP0005645_abnormal_hypothalamus_physiol0.35284142
88MP0000598_abnormal_liver_morphology0.34583265
89MP0005636_abnormal_mineral_homeostasis0.33920283
90MP0002882_abnormal_neuron_morphology0.33857398
91MP0004197_abnormal_fetal_growth/weight/0.32709678
92MP0001845_abnormal_inflammatory_respons0.32558486
93MP0000477_abnormal_intestine_morphology0.32525385
94MP0001533_abnormal_skeleton_physiology0.32172194
95MP0002876_abnormal_thyroid_physiology0.32079332
96MP0002229_neurodegeneration0.31586908
97MP0001986_abnormal_taste_sensitivity0.30771674
98MP0001440_abnormal_grooming_behavior0.30318031
99MP0002998_abnormal_bone_remodeling0.30015286
100MP0002138_abnormal_hepatobiliary_system0.30011727

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of renal resorption (HP:0011038)9.04126433
2Abnormality of calcium-phosphate metabolism (HP:0100530)8.89848464
3Abnormality of the dental pulp (HP:0006479)7.76457239
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.35977394
5Abnormality of dental color (HP:0011073)7.23499608
6Polyuria (HP:0000103)6.83893382
7Abnormality of renal excretion (HP:0011036)6.04037023
8Abnormal urine output (HP:0012590)5.83408029
9Chronic bronchitis (HP:0004469)5.31648630
10Chronic hepatic failure (HP:0100626)5.02777543
11Volvulus (HP:0002580)4.93476473
12Round ear (HP:0100830)4.40573684
13Nephrocalcinosis (HP:0000121)4.25725543
14Molar tooth sign on MRI (HP:0002419)4.20969721
15Abnormality of midbrain morphology (HP:0002418)4.20969721
16Abnormal respiratory motile cilium physiology (HP:0012261)3.69325650
17Lip pit (HP:0100267)3.67164823
18IgM deficiency (HP:0002850)3.63399416
19Abnormal urine phosphate concentration (HP:0012599)3.53337093
20Rhinitis (HP:0012384)3.46887029
21Autoimmune thrombocytopenia (HP:0001973)3.33107772
22Toxemia of pregnancy (HP:0100603)3.22110341
23Esophageal varix (HP:0002040)3.18152922
24Vascular calcification (HP:0004934)2.95647626
25Hyperphosphaturia (HP:0003109)2.93376070
26Tachypnea (HP:0002789)2.91142214
27Lipoatrophy (HP:0100578)2.89954865
28Nephronophthisis (HP:0000090)2.80865385
29Drooling (HP:0002307)2.79201011
30Sparse lateral eyebrow (HP:0005338)2.74937677
31Hypoparathyroidism (HP:0000829)2.72560259
32Chondrocalcinosis (HP:0000934)2.69522909
33Depressed nasal tip (HP:0000437)2.68685408
34Intestinal fistula (HP:0100819)2.67297570
35Cardiovascular calcification (HP:0011915)2.65647067
36Abnormality of urine glucose concentration (HP:0011016)2.64932587
37Glycosuria (HP:0003076)2.64932587
38Excessive salivation (HP:0003781)2.64169858
39Abnormality of Sharpey fibers (HP:0100685)2.60271943
40Panhypogammaglobulinemia (HP:0003139)2.54679961
41Thick eyebrow (HP:0000574)2.46307763
42Large earlobe (HP:0009748)2.33531087
43Premature ovarian failure (HP:0008209)2.32339370
44Nephropathy (HP:0000112)2.31930172
45Personality changes (HP:0000751)2.23452449
46Bronchitis (HP:0012387)2.21569526
47Dilated cardiomyopathy (HP:0001644)2.18890117
48Ureteral stenosis (HP:0000071)2.17010043
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.16369478
50Hyperphosphatemia (HP:0002905)2.11685290
51Ectopic kidney (HP:0000086)2.09959249
52Abnormality of the renal medulla (HP:0100957)2.07871992
53Decreased muscle mass (HP:0003199)2.07053646
54Small hand (HP:0200055)2.02334450
55Periauricular skin pits (HP:0100277)2.01485476
56Preauricular pit (HP:0004467)2.01485476
57Osteomalacia (HP:0002749)10.5219117
58Overgrowth (HP:0001548)10.3886750
59Amelogenesis imperfecta (HP:0000705)10.2423828
60Hypercalciuria (HP:0002150)1.99711937
61Petechiae (HP:0000967)1.97981497
62Hepatitis (HP:0012115)1.96583634
63Ureteral obstruction (HP:0006000)1.93937639
64Abnormality of transition element cation homeostasis (HP:0011030)1.93797734
65Chorioretinal coloboma (HP:0000567)1.93769742
66Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.93157258
67Short 5th finger (HP:0009237)1.91696381
68Gingival overgrowth (HP:0000212)1.88697563
69Recurrent otitis media (HP:0000403)1.85019549
70Inability to walk (HP:0002540)1.83889303
71Renal tubular dysfunction (HP:0000124)1.82864269
72Recurrent cutaneous fungal infections (HP:0011370)1.81177321
73Chronic mucocutaneous candidiasis (HP:0002728)1.81177321
74Sudden cardiac death (HP:0001645)1.72768725
75Striae distensae (HP:0001065)1.71517786
76Preauricular skin tag (HP:0000384)1.68234172
77Abnormality of salivation (HP:0100755)1.67338857
78Delayed eruption of teeth (HP:0000684)1.65349001
79Oculomotor apraxia (HP:0000657)1.63107749
80Abnormality of the fingertips (HP:0001211)1.59629998
81Bronchiectasis (HP:0002110)1.56784121
82Highly arched eyebrow (HP:0002553)1.56060568
83Anal stenosis (HP:0002025)1.55073824
84Blepharitis (HP:0000498)1.54649055
85Prominent supraorbital ridges (HP:0000336)1.52443085
86Proximal placement of thumb (HP:0009623)1.52103438
87Agammaglobulinemia (HP:0004432)1.49871325
88Rickets (HP:0002748)1.49262462
89Colitis (HP:0002583)1.48483534
90Villous atrophy (HP:0011473)1.48388454
91Abnormality of small intestinal villus morphology (HP:0011472)1.48388454
92Septo-optic dysplasia (HP:0100842)1.47895311
93Abnormal number of erythroid precursors (HP:0012131)1.47877534
94Stage 5 chronic kidney disease (HP:0003774)1.47403172
95Hypergonadotropic hypogonadism (HP:0000815)1.47089700
96Absent/shortened dynein arms (HP:0200106)1.44614210
97Dynein arm defect of respiratory motile cilia (HP:0012255)1.44614210
98Palmoplantar keratoderma (HP:0000982)1.39269801
99Prenatal maternal abnormality (HP:0002686)1.37253688
100Skin tags (HP:0010609)1.36479098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.27036980
2STK33.97770323
3BLK3.93723102
4RIPK42.78048654
5BMPR22.16841596
6NTRK213.9216274
7CDC42BPA1.99697268
8INSRR1.15162146
9PLK40.99925746
10HIPK20.99017565
11MST40.89293401
12FGFR10.84748482
13GRK10.82429244
14WNK30.72666871
15ROCK20.70125337
16CDC70.67801636
17TLK10.63422164
18PRKCQ0.62470966
19OBSCN0.61611466
20OXSR10.59951346
21ADRBK20.59318708
22TIE10.58642146
23SRC0.57139663
24SYK0.55449901
25PINK10.55246413
26PLK10.55062361
27GRK70.53454470
28ROCK10.48992424
29PRKAA10.48520817
30BMPR1B0.47906295
31PHKG20.46343549
32PHKG10.46343549
33PRKACA0.45649166
34PRKACG0.45543624
35MUSK0.45417784
36TXK0.43823690
37PRKACB0.42509471
38ABL10.42496782
39MAPK150.40782295
40WNK40.40167137
41ERBB40.39474019
42ABL20.37759197
43STK390.36280537
44STK160.35894223
45PRKCG0.34811512
46MAPK140.34284169
47MAP4K20.33976497
48CAMK2A0.33945593
49BCKDK0.32596006
50PRKCA0.30567601
51PNCK0.28016699
52MAPK130.27413696
53RPS6KA30.27217041
54LYN0.26889217
55TEC0.26852663
56GSK3B0.26343770
57MAP2K60.25891929
58GRK50.25470610
59EPHB20.25434161
60PLK20.25168477
61MAPKAPK50.24773710
62TNIK0.23974934
63PRKCB0.23782095
64DDR20.23619304
65FRK0.23303939
66CDK10.22936115
67SGK10.22478905
68CSNK1A10.22080016
69PRKCI0.20095139
70PRKDC0.19072699
71ADRBK10.18976049
72VRK10.18885175
73WEE10.17766355
74PRKCH0.16385952
75GRK60.15866033
76PRKCD0.15562056
77MAP3K90.15038515
78MATK0.14934794
79SGK20.14290224
80AKT10.14027201
81KIT0.13572172
82MAP2K70.13419472
83CASK0.12867900
84CHUK0.12459021
85FYN0.12275902
86PAK30.12082834
87SGK2230.11601938
88SGK4940.11601938
89PIM10.11342856
90PRKCE0.11223806
91PRKG10.11184739
92MARK10.10470806
93CSNK1E0.08906079
94PIK3CG0.08647404
95MAPK90.08526334
96PLK30.08442719
97ITK0.08219476
98CSNK2A10.07150179
99CDK20.06692783
100DYRK20.06605029

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.20852709
2Sulfur relay system_Homo sapiens_hsa041224.47116284
3Sulfur metabolism_Homo sapiens_hsa009203.80654462
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.46911591
5Linoleic acid metabolism_Homo sapiens_hsa005913.31012861
6Ovarian steroidogenesis_Homo sapiens_hsa049133.21036938
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.53620266
8Collecting duct acid secretion_Homo sapiens_hsa049662.45636588
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.39180750
10Bile secretion_Homo sapiens_hsa049762.27011964
11Fat digestion and absorption_Homo sapiens_hsa049752.26293897
12Vibrio cholerae infection_Homo sapiens_hsa051102.15688959
13Pancreatic secretion_Homo sapiens_hsa049722.11754841
14Gastric acid secretion_Homo sapiens_hsa049712.06887700
15Thyroid hormone synthesis_Homo sapiens_hsa049182.05324522
16Synaptic vesicle cycle_Homo sapiens_hsa047212.04019970
17Salivary secretion_Homo sapiens_hsa049701.94399452
18Cocaine addiction_Homo sapiens_hsa050301.87032583
19Circadian entrainment_Homo sapiens_hsa047131.81816376
20Ether lipid metabolism_Homo sapiens_hsa005651.79696992
21Glutamatergic synapse_Homo sapiens_hsa047241.78564770
22Taste transduction_Homo sapiens_hsa047421.74883532
23Insulin secretion_Homo sapiens_hsa049111.74686851
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.65446185
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64614028
26Morphine addiction_Homo sapiens_hsa050321.61407512
27GABAergic synapse_Homo sapiens_hsa047271.51919919
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49078363
29Dilated cardiomyopathy_Homo sapiens_hsa054141.43072831
30Arachidonic acid metabolism_Homo sapiens_hsa005901.41804176
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.37638450
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36133456
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34417812
34Amphetamine addiction_Homo sapiens_hsa050311.31135744
35Gap junction_Homo sapiens_hsa045401.26973659
36Melanogenesis_Homo sapiens_hsa049161.22096370
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20331896
38GnRH signaling pathway_Homo sapiens_hsa049121.11060974
39Pyruvate metabolism_Homo sapiens_hsa006201.10767205
40Oxytocin signaling pathway_Homo sapiens_hsa049211.08760430
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04678374
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04079560
43Cholinergic synapse_Homo sapiens_hsa047251.03780062
44Calcium signaling pathway_Homo sapiens_hsa040201.02229862
45Platelet activation_Homo sapiens_hsa046110.90287737
46Estrogen signaling pathway_Homo sapiens_hsa049150.89173716
47Parkinsons disease_Homo sapiens_hsa050120.82744205
48Oxidative phosphorylation_Homo sapiens_hsa001900.79472750
49Oocyte meiosis_Homo sapiens_hsa041140.76899035
50RNA degradation_Homo sapiens_hsa030180.74845399
51Serotonergic synapse_Homo sapiens_hsa047260.73527545
52Dorso-ventral axis formation_Homo sapiens_hsa043200.70809510
53Circadian rhythm_Homo sapiens_hsa047100.63901250
54Rheumatoid arthritis_Homo sapiens_hsa053230.62199942
55ECM-receptor interaction_Homo sapiens_hsa045120.57196676
56Retinol metabolism_Homo sapiens_hsa008300.56911151
57Chemokine signaling pathway_Homo sapiens_hsa040620.53988917
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52857623
59Caffeine metabolism_Homo sapiens_hsa002320.50708831
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.48780837
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44393267
62cAMP signaling pathway_Homo sapiens_hsa040240.43328375
63Chemical carcinogenesis_Homo sapiens_hsa052040.42725282
64Purine metabolism_Homo sapiens_hsa002300.41301374
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.40813505
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38889238
67Vitamin digestion and absorption_Homo sapiens_hsa049770.37851581
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36452004
69Nicotine addiction_Homo sapiens_hsa050330.34049651
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.33180838
71Dopaminergic synapse_Homo sapiens_hsa047280.33118995
72Homologous recombination_Homo sapiens_hsa034400.32665419
73Primary immunodeficiency_Homo sapiens_hsa053400.31139444
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.29305536
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26183621
76Alcoholism_Homo sapiens_hsa050340.25095310
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23783837
78Tyrosine metabolism_Homo sapiens_hsa003500.23311494
79Staphylococcus aureus infection_Homo sapiens_hsa051500.23294874
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23235414
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.23174770
82Rap1 signaling pathway_Homo sapiens_hsa040150.22841861
83Phototransduction_Homo sapiens_hsa047440.22085565
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21236304
85Ras signaling pathway_Homo sapiens_hsa040140.19940781
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19551937
87Hedgehog signaling pathway_Homo sapiens_hsa043400.19492222
88Galactose metabolism_Homo sapiens_hsa000520.14889396
89RNA polymerase_Homo sapiens_hsa030200.14468426
90Huntingtons disease_Homo sapiens_hsa050160.14017136
91Systemic lupus erythematosus_Homo sapiens_hsa053220.12885228
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12427494
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.08459198
94Complement and coagulation cascades_Homo sapiens_hsa046100.05092919
95Glucagon signaling pathway_Homo sapiens_hsa049220.04827783
96Alzheimers disease_Homo sapiens_hsa050100.03618005
97Prion diseases_Homo sapiens_hsa050200.02608164
98Type I diabetes mellitus_Homo sapiens_hsa049400.01256213
99Phagosome_Homo sapiens_hsa041450.00132902
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.00068232

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