EIF2S2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)5.38170479
2maturation of SSU-rRNA (GO:0030490)4.88662455
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.85673585
4proteasome assembly (GO:0043248)4.77909819
5purine nucleobase biosynthetic process (GO:0009113)4.72586993
6formation of translation preinitiation complex (GO:0001731)4.69064414
7mitotic metaphase plate congression (GO:0007080)4.64406251
8establishment of integrated proviral latency (GO:0075713)4.59213142
9nucleobase biosynthetic process (GO:0046112)4.58756125
10ribosomal large subunit biogenesis (GO:0042273)4.37363137
11ribosome biogenesis (GO:0042254)4.18029677
12ribonucleoprotein complex biogenesis (GO:0022613)4.14556376
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.13817753
14cotranslational protein targeting to membrane (GO:0006613)4.13434278
15DNA replication checkpoint (GO:0000076)4.13351878
16protein targeting to ER (GO:0045047)4.11455970
17ribosomal small subunit biogenesis (GO:0042274)4.06296503
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.06014530
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.05204246
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.04298922
21regulation of mitochondrial translation (GO:0070129)4.02471036
22chaperone-mediated protein transport (GO:0072321)4.00578988
23establishment of protein localization to endoplasmic reticulum (GO:0072599)3.98088858
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.96902672
25rRNA modification (GO:0000154)3.95023302
26folic acid-containing compound biosynthetic process (GO:0009396)3.93520439
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.91187230
28ATP synthesis coupled proton transport (GO:0015986)3.91187230
29termination of RNA polymerase III transcription (GO:0006386)3.84869115
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.84869115
31protein localization to endoplasmic reticulum (GO:0070972)3.81281444
32rRNA processing (GO:0006364)3.77154489
33metaphase plate congression (GO:0051310)3.76361593
34DNA replication initiation (GO:0006270)3.75383725
35translational termination (GO:0006415)3.74950751
36* translational initiation (GO:0006413)3.74519221
37folic acid metabolic process (GO:0046655)3.72840948
38telomere maintenance via recombination (GO:0000722)3.72594245
39DNA unwinding involved in DNA replication (GO:0006268)3.71089036
40negative regulation of ligase activity (GO:0051352)3.70007143
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70007143
42viral transcription (GO:0019083)3.69299560
43rRNA metabolic process (GO:0016072)3.66220452
44spliceosomal snRNP assembly (GO:0000387)3.65459926
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.64729614
46mitotic chromosome condensation (GO:0007076)3.64083962
47protein localization to kinetochore (GO:0034501)3.60449774
48transcription elongation from RNA polymerase I promoter (GO:0006362)3.59044187
49CENP-A containing nucleosome assembly (GO:0034080)3.58601899
50establishment of viral latency (GO:0019043)3.58585689
51regulation of sister chromatid cohesion (GO:0007063)3.57691432
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.57570704
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.57570704
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.57570704
55DNA strand elongation involved in DNA replication (GO:0006271)3.56450607
56regulation of spindle organization (GO:0090224)3.56401804
577-methylguanosine mRNA capping (GO:0006370)3.55712313
58termination of RNA polymerase I transcription (GO:0006363)3.55588905
59chromatin remodeling at centromere (GO:0031055)3.55488764
60cellular protein complex disassembly (GO:0043624)3.55438357
61viral life cycle (GO:0019058)3.53342964
62mitotic recombination (GO:0006312)3.52984843
63transcription from RNA polymerase I promoter (GO:0006360)3.51562044
64regulation of cellular amino acid metabolic process (GO:0006521)3.48884641
65non-recombinational repair (GO:0000726)3.48774695
66double-strand break repair via nonhomologous end joining (GO:0006303)3.48774695
67RNA capping (GO:0036260)3.47812815
687-methylguanosine RNA capping (GO:0009452)3.47812815
69nuclear pore complex assembly (GO:0051292)3.46742789
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45183878
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44423382
72mitotic sister chromatid segregation (GO:0000070)3.43663007
73positive regulation of ligase activity (GO:0051351)3.43121329
74DNA deamination (GO:0045006)3.42770785
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.42275609
76signal transduction involved in DNA integrity checkpoint (GO:0072401)3.42275609
77ribosomal small subunit assembly (GO:0000028)3.41406252
78regulation of translational fidelity (GO:0006450)3.38783367
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.36863629
80translational elongation (GO:0006414)3.36770231
81DNA replication-dependent nucleosome organization (GO:0034723)3.36686342
82DNA replication-dependent nucleosome assembly (GO:0006335)3.36686342
83DNA strand elongation (GO:0022616)3.36614450
84mitotic nuclear envelope disassembly (GO:0007077)3.36253474
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.36184506
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36184506
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.36184506
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35074520
89L-serine metabolic process (GO:0006563)3.30629583
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29876980
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29876980
92blastocyst development (GO:0001824)3.27991268
93establishment of chromosome localization (GO:0051303)3.27375870
94positive regulation of chromosome segregation (GO:0051984)3.25825325
95spindle checkpoint (GO:0031577)3.25158602
96tRNA aminoacylation for protein translation (GO:0006418)3.24753494
97* translation (GO:0006412)3.24230756
98regulation of ubiquitin-protein transferase activity (GO:0051438)3.23782845
99transcription-coupled nucleotide-excision repair (GO:0006283)3.22785501
100regulation of translation in response to stress (GO:0043555)3.22331287
101DNA replication-independent nucleosome organization (GO:0034724)3.22078370
102DNA replication-independent nucleosome assembly (GO:0006336)3.22078370
103tRNA aminoacylation (GO:0043039)3.21572853
104amino acid activation (GO:0043038)3.21572853
105respiratory electron transport chain (GO:0022904)3.20780695
106kinetochore organization (GO:0051383)3.20141129
107histone exchange (GO:0043486)3.20131915
108transcription initiation from RNA polymerase I promoter (GO:0006361)3.20009148
109IMP biosynthetic process (GO:0006188)3.18757113
110cell cycle G1/S phase transition (GO:0044843)3.18520756
111G1/S transition of mitotic cell cycle (GO:0000082)3.18520756
112nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18014828
113chaperone-mediated protein complex assembly (GO:0051131)3.17726217
114telomere maintenance via semi-conservative replication (GO:0032201)3.16019512
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15703374
116protein complex disassembly (GO:0043241)3.15377951
117attachment of spindle microtubules to kinetochore (GO:0008608)3.13932860
118mitotic spindle checkpoint (GO:0071174)3.13194357
119cellular component biogenesis (GO:0044085)3.13155092
120maturation of 5.8S rRNA (GO:0000460)3.12942554
121pteridine-containing compound biosynthetic process (GO:0042559)3.12831830
122regulation of nuclear cell cycle DNA replication (GO:0033262)3.12494428
123kinetochore assembly (GO:0051382)3.11321808
124protein targeting to mitochondrion (GO:0006626)3.11173712
125nucleobase-containing small molecule interconversion (GO:0015949)3.10867762
126membrane disassembly (GO:0030397)3.10641718
127nuclear envelope disassembly (GO:0051081)3.10641718
128sister chromatid segregation (GO:0000819)3.10257489
129electron transport chain (GO:0022900)3.09475553
130pseudouridine synthesis (GO:0001522)3.09143932
131protein localization to chromosome, centromeric region (GO:0071459)3.07724086
132regulation of ligase activity (GO:0051340)3.07367639
133negative regulation of chromosome segregation (GO:0051985)3.06815625
134negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06296447
135negative regulation of sister chromatid segregation (GO:0033046)3.06296447
136negative regulation of mitotic sister chromatid separation (GO:2000816)3.06296447
137negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06296447
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06014159
139nuclear pore organization (GO:0006999)3.05896209
140regulation of chromosome segregation (GO:0051983)3.05480593
141spliceosomal complex assembly (GO:0000245)3.05201198
142macromolecular complex disassembly (GO:0032984)3.04824270
143tetrahydrofolate metabolic process (GO:0046653)3.02639290
144rRNA methylation (GO:0031167)2.99972621
145regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99618405
146regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99618405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.38676762
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.47113724
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.80219212
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68851862
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.41713479
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.41438447
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.39693040
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.39498747
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.37106148
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.28769494
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24934003
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23878338
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21398611
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02164808
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92968067
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79248621
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70710258
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51445478
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44586175
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44021867
21* VDR_23849224_ChIP-Seq_CD4+_Human2.39029265
22XRN2_22483619_ChIP-Seq_HELA_Human2.35236893
23AR_21909140_ChIP-Seq_LNCAP_Human2.27876420
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.23653529
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21919840
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15461124
27DCP1A_22483619_ChIP-Seq_HELA_Human2.11409551
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.09577339
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04736595
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01212010
31MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00006701
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92746543
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91336483
34TTF2_22483619_ChIP-Seq_HELA_Human1.90371822
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90225083
36FOXP3_21729870_ChIP-Seq_TREG_Human1.87363694
37* GABP_19822575_ChIP-Seq_HepG2_Human1.87188438
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85753921
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79949067
40ELK1_19687146_ChIP-ChIP_HELA_Human1.79440463
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.78978014
42* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76486253
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74568965
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74568965
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74568965
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66846301
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64812483
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63833179
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62121446
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61096076
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56576165
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.54188242
53KDM5A_27292631_Chip-Seq_BREAST_Human1.51372101
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.48673350
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45506452
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45496244
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45495597
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44041101
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42505179
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30964325
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.30849423
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30229306
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30114904
64* SRF_21415370_ChIP-Seq_HL-1_Mouse1.29012118
65* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27394170
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23859485
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23118163
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22093268
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21390196
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20908831
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18804112
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18679090
73CIITA_25753668_ChIP-Seq_RAJI_Human1.18587083
74* ZNF263_19887448_ChIP-Seq_K562_Human1.18555480
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17641879
76* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16548636
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13911525
78SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13777521
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12085806
80* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07826769
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.05812632
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05240220
83TFEB_21752829_ChIP-Seq_HELA_Human1.03926783
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03674210
85* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02812062
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02675030
87TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02244447
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02118505
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01298437
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.00368333
91* NANOG_21062744_ChIP-ChIP_HESCs_Human1.00320666
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.00309436
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99266980
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.97749705
95TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97318782
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96749274
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95592854
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94731001
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94287163
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92523958
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92426246
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91461384
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90988708
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89946509
105EGR1_19374776_ChIP-ChIP_THP-1_Human0.88200115
106* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88149957
107* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86584497
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86280744
109MYC_18940864_ChIP-ChIP_HL60_Human0.86159054
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85148559
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84779257
112* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84565782
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83125511
114SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81404174
115GATA1_22025678_ChIP-Seq_K562_Human0.80913188
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79712749
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79381636
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78673295
119ELF5_23300383_ChIP-Seq_T47D_Human0.78540928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.50137336
2MP0004957_abnormal_blastocyst_morpholog5.10289988
3MP0003111_abnormal_nucleus_morphology4.96103885
4MP0010094_abnormal_chromosome_stability4.05257200
5MP0003077_abnormal_cell_cycle3.94195406
6MP0008057_abnormal_DNA_replication3.50225178
7MP0003718_maternal_effect3.35105495
8MP0000566_synostosis3.29259969
9MP0008932_abnormal_embryonic_tissue3.18563563
10MP0008058_abnormal_DNA_repair3.08592138
11MP0001730_embryonic_growth_arrest2.62893595
12MP0003123_paternal_imprinting2.42865355
13MP0003786_premature_aging2.36205514
14MP0003806_abnormal_nucleotide_metabolis2.29930511
15MP0008007_abnormal_cellular_replicative2.26166651
16MP0000350_abnormal_cell_proliferation2.19380656
17MP0006292_abnormal_olfactory_placode2.12288879
18MP0010352_gastrointestinal_tract_polyps1.95376442
19MP0003315_abnormal_perineum_morphology1.92634069
20MP0001672_abnormal_embryogenesis/_devel1.91092965
21MP0005380_embryogenesis_phenotype1.91092965
22MP0008260_abnormal_autophagy1.86077235
23MP0009697_abnormal_copulation1.84659452
24MP0001697_abnormal_embryo_size1.84522279
25MP0003941_abnormal_skin_development1.78236409
26MP0002877_abnormal_melanocyte_morpholog1.74673256
27MP0003567_abnormal_fetal_cardiomyocyte1.70957135
28MP0002085_abnormal_embryonic_tissue1.70352302
29MP0008877_abnormal_DNA_methylation1.67796968
30* MP0002080_prenatal_lethality1.65204983
31MP0003984_embryonic_growth_retardation1.62183974
32MP0002088_abnormal_embryonic_growth/wei1.60401704
33MP0003136_yellow_coat_color1.57601051
34MP0002084_abnormal_developmental_patter1.55978542
35MP0002086_abnormal_extraembryonic_tissu1.40270821
36MP0010307_abnormal_tumor_latency1.38903117
37MP0004197_abnormal_fetal_growth/weight/1.35585533
38MP0002697_abnormal_eye_size1.34364206
39MP0002938_white_spotting1.30643564
40MP0005395_other_phenotype1.29255522
41* MP0002210_abnormal_sex_determination1.25106451
42MP0000313_abnormal_cell_death1.20424732
43MP0003937_abnormal_limbs/digits/tail_de1.20179020
44MP0000537_abnormal_urethra_morphology1.19118259
45MP0003705_abnormal_hypodermis_morpholog1.17899436
46* MP0001145_abnormal_male_reproductive1.17626773
47MP0003950_abnormal_plasma_membrane1.17355170
48MP0000467_abnormal_esophagus_morphology1.16776785
49MP0004233_abnormal_muscle_weight1.13200858
50MP0003119_abnormal_digestive_system1.12720438
51MP0001542_abnormal_bone_strength1.12632803
52MP0000358_abnormal_cell_content/1.12295880
53MP0004185_abnormal_adipocyte_glucose1.11644677
54MP0001881_abnormal_mammary_gland1.11088335
55MP0001293_anophthalmia1.09465248
56MP0000750_abnormal_muscle_regeneration1.09326203
57MP0000490_abnormal_crypts_of1.08356011
58MP0001727_abnormal_embryo_implantation1.05637719
59MP0004272_abnormal_basement_membrane1.04422292
60MP0001929_abnormal_gametogenesis1.04291160
61MP0002160_abnormal_reproductive_system1.02214861
62MP0001661_extended_life_span1.02158027
63MP0006035_abnormal_mitochondrial_morpho1.00545380
64MP0003221_abnormal_cardiomyocyte_apopto0.99804891
65MP0002396_abnormal_hematopoietic_system0.99576201
66MP0002653_abnormal_ependyma_morphology0.99405612
67MP0010234_abnormal_vibrissa_follicle0.97875063
68MP0009379_abnormal_foot_pigmentation0.97827380
69MP0003186_abnormal_redox_activity0.97822941
70* MP0000653_abnormal_sex_gland0.96533867
71MP0010030_abnormal_orbit_morphology0.96317956
72MP0000579_abnormal_nail_morphology0.95966971
73MP0003942_abnormal_urinary_system0.95210879
74MP0002111_abnormal_tail_morphology0.94062815
75MP0009333_abnormal_splenocyte_physiolog0.93880326
76MP0005377_hearing/vestibular/ear_phenot0.93412086
77MP0003878_abnormal_ear_physiology0.93412086
78MP0002254_reproductive_system_inflammat0.91617974
79* MP0002019_abnormal_tumor_incidence0.91087893
80MP0003890_abnormal_embryonic-extraembry0.90595575
81MP0009053_abnormal_anal_canal0.89883126
82MP0003938_abnormal_ear_development0.88135845
83MP0001188_hyperpigmentation0.87360617
84MP0004133_heterotaxia0.86663454
85MP0005384_cellular_phenotype0.86598164
86MP0003115_abnormal_respiratory_system0.85065836
87MP0004084_abnormal_cardiac_muscle0.84738951
88MP0003936_abnormal_reproductive_system0.84332707
89MP0000627_abnormal_mammary_gland0.84060530
90MP0001286_abnormal_eye_development0.83108725
91MP0009672_abnormal_birth_weight0.82440127
92MP0005621_abnormal_cell_physiology0.82382026
93MP0000428_abnormal_craniofacial_morphol0.80830290
94MP0009840_abnormal_foam_cell0.78374260
95MP0003453_abnormal_keratinocyte_physiol0.78289383
96MP0005367_renal/urinary_system_phenotyp0.77913188
97MP0000516_abnormal_urinary_system0.77913188
98MP0005076_abnormal_cell_differentiation0.77387729
99MP0009703_decreased_birth_body0.76651175
100MP0001915_intracranial_hemorrhage0.76436002
101MP0005197_abnormal_uvea_morphology0.75177351
102MP0003385_abnormal_body_wall0.73028378
103MP0002060_abnormal_skin_morphology0.72214314
104MP0005501_abnormal_skin_physiology0.71560655
105MP0003755_abnormal_palate_morphology0.71431559
106MP0005451_abnormal_body_composition0.69384493
107MP0000647_abnormal_sebaceous_gland0.69306366
108MP0000049_abnormal_middle_ear0.69074767
109MP0002796_impaired_skin_barrier0.68999459
110MP0009250_abnormal_appendicular_skeleto0.66100060
111MP0002092_abnormal_eye_morphology0.65738538
112MP0006036_abnormal_mitochondrial_physio0.65334778
113MP0002233_abnormal_nose_morphology0.63378288
114MP0000762_abnormal_tongue_morphology0.62765001
115MP0001119_abnormal_female_reproductive0.61878569
116MP0003121_genomic_imprinting0.61507960
117MP0003566_abnormal_cell_adhesion0.61439706
118* MP0005389_reproductive_system_phenotype0.61124460
119MP0008995_early_reproductive_senescence0.59722230
120MP0000432_abnormal_head_morphology0.59691639
121MP0005023_abnormal_wound_healing0.59663024
122MP0005408_hypopigmentation0.59473131
123MP0010771_integument_phenotype0.58801674
124MP0002277_abnormal_respiratory_mucosa0.55581543
125MP0002102_abnormal_ear_morphology0.54166139
126MP0003698_abnormal_male_reproductive0.54092621
127MP0003699_abnormal_female_reproductive0.52524798
128MP0003861_abnormal_nervous_system0.52446314

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.72290178
2Birth length less than 3rd percentile (HP:0003561)5.34211216
3Carpal bone hypoplasia (HP:0001498)4.45194290
4Cerebral hypomyelination (HP:0006808)4.37131698
5Acute necrotizing encephalopathy (HP:0006965)3.94574515
6Rough bone trabeculation (HP:0100670)3.88881856
7Abnormal mitochondria in muscle tissue (HP:0008316)3.66463552
8Absent radius (HP:0003974)3.59849383
9Acute encephalopathy (HP:0006846)3.54353972
10Reticulocytopenia (HP:0001896)3.53812268
11Impulsivity (HP:0100710)3.47996597
12Patellar aplasia (HP:0006443)3.43144710
13Aplasia/Hypoplasia of the patella (HP:0006498)3.43143191
14Abnormality of cells of the erythroid lineage (HP:0012130)3.38990513
15Absent forearm bone (HP:0003953)3.37996871
16Aplasia involving forearm bones (HP:0009822)3.37996871
17Lipid accumulation in hepatocytes (HP:0006561)3.31237725
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.24313125
19Macrocytic anemia (HP:0001972)3.22788864
20Abnormality of the labia minora (HP:0012880)3.19275267
21Aplastic anemia (HP:0001915)3.17547792
22Increased CSF lactate (HP:0002490)3.13354581
23Mitochondrial inheritance (HP:0001427)3.11635750
24Oral leukoplakia (HP:0002745)3.09777017
25Progressive macrocephaly (HP:0004481)3.02127746
26Abnormal number of erythroid precursors (HP:0012131)2.99357093
27Ureteral duplication (HP:0000073)2.97391062
28Premature ovarian failure (HP:0008209)2.95853200
29Abnormality of the umbilical cord (HP:0010881)2.94224318
30Secondary amenorrhea (HP:0000869)2.93203089
31Degeneration of anterior horn cells (HP:0002398)2.90517438
32Abnormality of the anterior horn cell (HP:0006802)2.90517438
33Abnormal trabecular bone morphology (HP:0100671)2.88437879
34Cerebral edema (HP:0002181)2.87100458
35Aplasia/Hypoplasia involving the musculature (HP:0001460)2.82010680
36Duplicated collecting system (HP:0000081)2.79958972
37Trismus (HP:0000211)2.78959143
38Meckel diverticulum (HP:0002245)2.74692564
39Multiple enchondromatosis (HP:0005701)2.70041998
40Colon cancer (HP:0003003)2.68144353
41CNS hypomyelination (HP:0003429)2.66012128
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65255112
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65255112
44Aplasia/hypoplasia of the humerus (HP:0006507)2.63313591
45Hepatocellular necrosis (HP:0001404)2.62814660
46Hypoplastic pelvis (HP:0008839)2.62417546
47Stenosis of the external auditory canal (HP:0000402)2.62291934
48Horseshoe kidney (HP:0000085)2.62004368
49Increased serum pyruvate (HP:0003542)2.60530886
50Abnormality of the preputium (HP:0100587)2.59219029
51Abnormal lung lobation (HP:0002101)2.53956192
52Ependymoma (HP:0002888)2.52599586
53Renal Fanconi syndrome (HP:0001994)2.52297665
54Absent thumb (HP:0009777)2.52199649
55Abnormality of the ileum (HP:0001549)2.51433088
56Long foot (HP:0001833)2.50457152
57Microvesicular hepatic steatosis (HP:0001414)2.49927482
58Abnormality of the renal collecting system (HP:0004742)2.49023790
59Abnormality of methionine metabolism (HP:0010901)2.47638884
60Chromsome breakage (HP:0040012)2.46939870
61Amniotic constriction ring (HP:0009775)2.46154476
62Abnormality of placental membranes (HP:0011409)2.46154476
63Selective tooth agenesis (HP:0001592)2.45448505
64Lactic acidosis (HP:0003128)2.45317620
65Exercise intolerance (HP:0003546)2.45275025
66Neoplasm of the pancreas (HP:0002894)2.45084730
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39532666
68Increased intramyocellular lipid droplets (HP:0012240)2.37460500
69Hyperglycinemia (HP:0002154)2.33607917
70Abnormality of chromosome stability (HP:0003220)2.33451214
71Pallor (HP:0000980)2.33172634
72Abnormality of the fetal cardiovascular system (HP:0010948)2.32902143
73Abnormal umbilical cord blood vessels (HP:0011403)2.32902143
74Single umbilical artery (HP:0001195)2.32902143
75Hepatic necrosis (HP:0002605)2.32264839
76Sparse eyelashes (HP:0000653)2.27673094
77Premature graying of hair (HP:0002216)2.25842667
78Progressive muscle weakness (HP:0003323)2.20893753
79Microretrognathia (HP:0000308)2.20768407
80Irregular epiphyses (HP:0010582)2.20454029
81Fused cervical vertebrae (HP:0002949)2.19698404
82Triphalangeal thumb (HP:0001199)2.15575454
83Megaloblastic anemia (HP:0001889)2.14447962
84Facial cleft (HP:0002006)2.14289779
85Glossoptosis (HP:0000162)2.12088045
86Congenital, generalized hypertrichosis (HP:0004540)2.11803819
87Abnormalities of placenta or umbilical cord (HP:0001194)2.11052664
88Abnormal number of incisors (HP:0011064)2.10984881
89Bone marrow hypocellularity (HP:0005528)2.09550476
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09071700
91Abnormality of alanine metabolism (HP:0010916)2.09071700
92Hyperalaninemia (HP:0003348)2.09071700
93Agnosia (HP:0010524)2.07697070
94Respiratory difficulties (HP:0002880)2.07669508
95Absent hand (HP:0004050)2.06697873
96Personality changes (HP:0000751)2.06151654
97Postnatal microcephaly (HP:0005484)2.06084006
98Aplasia/Hypoplasia of the uvula (HP:0010293)2.05056725
99Sparse lateral eyebrow (HP:0005338)2.04759973
100Leukodystrophy (HP:0002415)2.04126833
101Increased hepatocellular lipid droplets (HP:0006565)2.02573037
102Increased nuchal translucency (HP:0010880)2.02433526
103Breast aplasia (HP:0100783)2.02159206
104Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02010618
105Respiratory failure (HP:0002878)2.00607585
106Hypoplasia of the radius (HP:0002984)1.99960407
107Atresia of the external auditory canal (HP:0000413)1.99040657
108Aplasia/Hypoplasia of the breasts (HP:0010311)1.96947309
109Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96534957
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96426241
111Small intestinal stenosis (HP:0012848)1.96392629
112Duodenal stenosis (HP:0100867)1.96392629
113Abnormality of serum amino acid levels (HP:0003112)1.96054291
114Shoulder girdle muscle weakness (HP:0003547)1.95914658
115Myelodysplasia (HP:0002863)1.94354708
116Exertional dyspnea (HP:0002875)1.93492406
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92806111
118Progressive external ophthalmoplegia (HP:0000590)1.92345096
119Nephroblastoma (Wilms tumor) (HP:0002667)1.92175948
1203-Methylglutaconic aciduria (HP:0003535)1.91792996
121Medulloblastoma (HP:0002885)1.90800481
122Reduced antithrombin III activity (HP:0001976)1.90368763
123Supernumerary spleens (HP:0009799)1.89579403
124Gout (HP:0001997)1.88429583
125Pancytopenia (HP:0001876)1.88284748
126Glioma (HP:0009733)1.87845985
127Aplasia/hypoplasia of the uterus (HP:0008684)1.87424323
128Abnormality of homocysteine metabolism (HP:0010919)1.87095413
129Homocystinuria (HP:0002156)1.87095413
130Aplasia/Hypoplasia of the earlobes (HP:0009906)1.86234932
131Biliary tract neoplasm (HP:0100574)1.85982045
132Pelvic girdle muscle weakness (HP:0003749)1.85923757
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.84417251
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84404713
135Cleft eyelid (HP:0000625)1.83577093
136Rhabdomyosarcoma (HP:0002859)1.83509205
137Septo-optic dysplasia (HP:0100842)1.83484652
138Death in infancy (HP:0001522)1.82799578
139Short humerus (HP:0005792)1.82312322
140Cellular immunodeficiency (HP:0005374)1.81308709
141Adrenal hypoplasia (HP:0000835)1.81060845
142Increased muscle lipid content (HP:0009058)1.80021995
143Patent foramen ovale (HP:0001655)1.79192720
144Increased serum lactate (HP:0002151)1.78398411
145Embryonal renal neoplasm (HP:0011794)1.77788431
146Nasolacrimal duct obstruction (HP:0000579)1.77610106
147Abnormality of the lacrimal duct (HP:0011481)1.77333270
148Delusions (HP:0000746)1.76600548
149Cortical dysplasia (HP:0002539)1.76300494
150Abnormality of glycolysis (HP:0004366)1.75406755
151Hypoplasia of the pons (HP:0012110)1.73574157
152Dry hair (HP:0011359)1.72674975
153Sensory axonal neuropathy (HP:0003390)1.72022694
154Acute lymphatic leukemia (HP:0006721)1.71664951
155Duplication of thumb phalanx (HP:0009942)1.70227456
156Reduced subcutaneous adipose tissue (HP:0003758)1.70037871
157Type I transferrin isoform profile (HP:0003642)1.68520292
158Abnormality of sulfur amino acid metabolism (HP:0004339)1.65873591
159Bilateral microphthalmos (HP:0007633)1.65032328
160Absent septum pellucidum (HP:0001331)1.64837318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.38862857
2WEE15.10145432
3EPHA23.62528221
4PNCK3.59689408
5EIF2AK13.32058693
6VRK23.13719319
7SRPK12.92287953
8PLK42.85277568
9TTK2.75705677
10STK162.73136039
11TSSK62.70295957
12NME22.24758079
13CDC72.23680781
14TAOK22.20551073
15NEK22.17418070
16NEK12.14502371
17EIF2AK32.02170249
18AKT31.94108508
19PLK11.90526074
20PLK31.89947637
21ZAK1.85960386
22TESK21.79769262
23BRSK21.78983273
24TAF11.53979980
25MKNK11.50945359
26NME11.49672819
27DYRK31.49101901
28RPS6KB21.43577738
29AURKB1.43355202
30TLK11.36910162
31CHEK21.36665335
32ACVR1B1.36332644
33IRAK31.35640147
34MKNK21.35460138
35AURKA1.31889059
36VRK11.17480917
37TAOK11.16147279
38MAP3K81.15458487
39PBK1.09792022
40STK38L1.09695701
41BRAF1.09307862
42CDK71.07974556
43LATS21.02148527
44ATR0.99881485
45ERBB40.98144350
46PDK40.96584494
47PDK30.96584494
48CHEK10.96060643
49BRSK10.93501381
50PRKCI0.92332256
51PDK20.85535784
52PAK40.82516341
53MAP3K120.82428227
54RPS6KA40.81427352
55DYRK20.81296025
56CDK40.77986841
57MST40.77592219
58ARAF0.77280058
59PAK10.75442415
60ALK0.72682420
61MAP2K30.72143818
62CDK20.69059270
63SMG10.67875704
64CSNK1E0.66706810
65PIM20.66361887
66* CSNK2A20.65507511
67STK30.65430331
68PASK0.64008957
69STK40.61928429
70* CSNK2A10.61353850
71ATM0.61159106
72MAP3K90.60660263
73MET0.60618363
74EIF2AK20.60155157
75MELK0.58982624
76RPS6KA50.56128574
77MAP3K100.55968705
78ABL20.55712186
79DMPK0.54025132
80CDK10.51940572
81LIMK10.51863482
82SCYL20.51013141
83TESK10.50299815
84CLK10.49064753
85CCNB10.49019751
86TNIK0.48933808
87WNK40.45854957
88MAP2K20.42596955
89MARK10.42476300
90BCR0.41055644
91PIM10.40656635
92STK100.40090819
93FGFR10.39766445
94CDK120.39681337
95KDR0.39504241
96CSNK1G30.39296964
97STK390.36718536
98MAP3K50.33674011
99PAK20.32832117
100MAPKAPK50.31069135
101LATS10.30716288
102MAP3K110.30031691
103CSNK1G10.28140925
104STK240.26242009
105PLK20.25875020
106PRKDC0.25555086
107CDK11A0.25463962
108BRD40.24996772
109DAPK30.24124804
110MTOR0.24102526
111NUAK10.23509421
112EEF2K0.22535727
113PTK20.21974392
114ILK0.21840915
115CSNK1D0.21343681
116CDK140.20840761
117LRRK20.20641869
118CDK150.19505275
119MAP3K30.19234924
120MST1R0.19091570
121IRAK20.18820242
122CDK60.18662498
123BCKDK0.17965723
124AKT20.17214211
125CSNK1A1L0.16373202
126CDK80.15253242

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.91717414
2RNA polymerase_Homo sapiens_hsa030204.35084816
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.14462496
4Ribosome_Homo sapiens_hsa030104.03330110
5DNA replication_Homo sapiens_hsa030303.62685568
6* RNA transport_Homo sapiens_hsa030133.41035694
7Mismatch repair_Homo sapiens_hsa034303.36365466
8Spliceosome_Homo sapiens_hsa030403.24629512
9Nucleotide excision repair_Homo sapiens_hsa034202.60751953
10Pyrimidine metabolism_Homo sapiens_hsa002402.58895153
11Vitamin B6 metabolism_Homo sapiens_hsa007502.58574474
12Homologous recombination_Homo sapiens_hsa034402.53314749
13Cell cycle_Homo sapiens_hsa041102.39963629
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34952196
15Basal transcription factors_Homo sapiens_hsa030222.14350614
16Base excision repair_Homo sapiens_hsa034102.12632893
17One carbon pool by folate_Homo sapiens_hsa006702.08109698
18Fanconi anemia pathway_Homo sapiens_hsa034602.00743480
19RNA degradation_Homo sapiens_hsa030181.62165083
20mRNA surveillance pathway_Homo sapiens_hsa030151.54143451
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49747449
22Purine metabolism_Homo sapiens_hsa002301.45128494
23p53 signaling pathway_Homo sapiens_hsa041151.44455302
24Non-homologous end-joining_Homo sapiens_hsa034501.41330676
25Pyruvate metabolism_Homo sapiens_hsa006201.41200068
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32016830
27Regulation of autophagy_Homo sapiens_hsa041401.31076087
28Epstein-Barr virus infection_Homo sapiens_hsa051691.30483449
29Oxidative phosphorylation_Homo sapiens_hsa001901.23309386
30Huntingtons disease_Homo sapiens_hsa050161.22334626
31Folate biosynthesis_Homo sapiens_hsa007901.17000806
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16354904
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12062278
34Pentose phosphate pathway_Homo sapiens_hsa000301.11934153
35Parkinsons disease_Homo sapiens_hsa050121.10818702
36Oocyte meiosis_Homo sapiens_hsa041141.08542181
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.07416888
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06308262
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03544880
40Protein export_Homo sapiens_hsa030600.98297498
41Glutathione metabolism_Homo sapiens_hsa004800.91970722
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87020946
43Propanoate metabolism_Homo sapiens_hsa006400.83720522
44Fatty acid elongation_Homo sapiens_hsa000620.81005370
45Fructose and mannose metabolism_Homo sapiens_hsa000510.77628613
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71899973
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71687392
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.71267846
49Biosynthesis of amino acids_Homo sapiens_hsa012300.70650843
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67232514
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66363911
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.61885578
53Sulfur relay system_Homo sapiens_hsa041220.58117243
54Viral carcinogenesis_Homo sapiens_hsa052030.57199986
55Systemic lupus erythematosus_Homo sapiens_hsa053220.56250695
56Carbon metabolism_Homo sapiens_hsa012000.56041533
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51073882
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50830561
59Hippo signaling pathway_Homo sapiens_hsa043900.50544190
60Alzheimers disease_Homo sapiens_hsa050100.49315015
61Antigen processing and presentation_Homo sapiens_hsa046120.49028937
62Sulfur metabolism_Homo sapiens_hsa009200.48795365
63N-Glycan biosynthesis_Homo sapiens_hsa005100.47718868
64Arachidonic acid metabolism_Homo sapiens_hsa005900.47140846
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47000769
66Metabolic pathways_Homo sapiens_hsa011000.46879307
67Selenocompound metabolism_Homo sapiens_hsa004500.45980916
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45678066
69Arginine and proline metabolism_Homo sapiens_hsa003300.45667572
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44765497
71Tight junction_Homo sapiens_hsa045300.44132132
72Linoleic acid metabolism_Homo sapiens_hsa005910.42032131
73Arginine biosynthesis_Homo sapiens_hsa002200.39885166
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.38798241
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37203817
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36887187
77HTLV-I infection_Homo sapiens_hsa051660.35354120
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31536819
79Herpes simplex infection_Homo sapiens_hsa051680.31140278
80MicroRNAs in cancer_Homo sapiens_hsa052060.31003943
81Hedgehog signaling pathway_Homo sapiens_hsa043400.29914498
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28159956
83TGF-beta signaling pathway_Homo sapiens_hsa043500.27855372
84Lysine degradation_Homo sapiens_hsa003100.27851593
85Sphingolipid metabolism_Homo sapiens_hsa006000.26305448
86Fatty acid metabolism_Homo sapiens_hsa012120.25559766
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24353776
88Wnt signaling pathway_Homo sapiens_hsa043100.24178719
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23917988
90Steroid biosynthesis_Homo sapiens_hsa001000.21901040
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20714893
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20543833
93beta-Alanine metabolism_Homo sapiens_hsa004100.20127172
94Vitamin digestion and absorption_Homo sapiens_hsa049770.19599368
95Thyroid cancer_Homo sapiens_hsa052160.18948527
96Renin-angiotensin system_Homo sapiens_hsa046140.18540076
97Fatty acid degradation_Homo sapiens_hsa000710.18392244
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.17531800
99Galactose metabolism_Homo sapiens_hsa000520.16643161
100Small cell lung cancer_Homo sapiens_hsa052220.15699723
101Ether lipid metabolism_Homo sapiens_hsa005650.15040356
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14621872
103Basal cell carcinoma_Homo sapiens_hsa052170.14574999
104Tyrosine metabolism_Homo sapiens_hsa003500.14044585
105Legionellosis_Homo sapiens_hsa051340.11883907
106HIF-1 signaling pathway_Homo sapiens_hsa040660.10905785
107Vibrio cholerae infection_Homo sapiens_hsa051100.10332622
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09462178
109Melanoma_Homo sapiens_hsa052180.09008449
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08031967
111Peroxisome_Homo sapiens_hsa041460.07969462
112Prostate cancer_Homo sapiens_hsa052150.07782288
113mTOR signaling pathway_Homo sapiens_hsa041500.07565650
114Cardiac muscle contraction_Homo sapiens_hsa042600.07545577
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07062298
116Shigellosis_Homo sapiens_hsa051310.04794363
117Renal cell carcinoma_Homo sapiens_hsa052110.04537785
118Apoptosis_Homo sapiens_hsa042100.03162666
119Adherens junction_Homo sapiens_hsa045200.02813510
120Bladder cancer_Homo sapiens_hsa052190.02628547
121Pathways in cancer_Homo sapiens_hsa052000.02477702
122Alcoholism_Homo sapiens_hsa05034-0.0157079
123FoxO signaling pathway_Homo sapiens_hsa04068-0.0074607

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