EIF2B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.02784237
2proteasome assembly (GO:0043248)4.45648474
3DNA replication checkpoint (GO:0000076)4.38328709
4purine nucleobase biosynthetic process (GO:0009113)4.36559601
5DNA deamination (GO:0045006)4.34446338
6CENP-A containing nucleosome assembly (GO:0034080)4.29423521
7pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.27277831
8nucleobase biosynthetic process (GO:0046112)4.20735906
9metaphase plate congression (GO:0051310)4.20158798
10attachment of spindle microtubules to kinetochore (GO:0008608)4.17165453
11maturation of SSU-rRNA (GO:0030490)4.16026706
12chromatin remodeling at centromere (GO:0031055)4.13011560
13DNA strand elongation involved in DNA replication (GO:0006271)4.12704412
14ribosome assembly (GO:0042255)4.11550813
15transcription elongation from RNA polymerase III promoter (GO:0006385)4.10796253
16termination of RNA polymerase III transcription (GO:0006386)4.10796253
17maturation of 5.8S rRNA (GO:0000460)4.07609973
18rRNA modification (GO:0000154)4.07358398
19DNA replication initiation (GO:0006270)4.04214973
20ribosome biogenesis (GO:0042254)4.02787898
21formation of translation preinitiation complex (GO:0001731)4.02124932
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.97845289
237-methylguanosine mRNA capping (GO:0006370)3.97638731
24pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.95059653
25DNA strand elongation (GO:0022616)3.91944720
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90483132
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.89893942
28telomere maintenance via semi-conservative replication (GO:0032201)3.88230419
297-methylguanosine RNA capping (GO:0009452)3.87019677
30RNA capping (GO:0036260)3.87019677
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.84561557
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.81832954
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.81832954
34ribosomal large subunit biogenesis (GO:0042273)3.79314894
35DNA replication-independent nucleosome organization (GO:0034724)3.76770944
36DNA replication-independent nucleosome assembly (GO:0006336)3.76770944
37ribonucleoprotein complex biogenesis (GO:0022613)3.72048502
38establishment of chromosome localization (GO:0051303)3.67450290
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66429080
40protein localization to kinetochore (GO:0034501)3.66227572
41base-excision repair, AP site formation (GO:0006285)3.65062696
42ribosomal small subunit assembly (GO:0000028)3.61704522
43protein deneddylation (GO:0000338)3.61109150
44spliceosomal snRNP assembly (GO:0000387)3.60847608
45transcription-coupled nucleotide-excision repair (GO:0006283)3.60168707
46telomere maintenance via recombination (GO:0000722)3.59028131
47rRNA processing (GO:0006364)3.56603085
48negative regulation of ligase activity (GO:0051352)3.55702483
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.55702483
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.54609419
51DNA unwinding involved in DNA replication (GO:0006268)3.54012433
52histone exchange (GO:0043486)3.53735166
53pyrimidine nucleotide catabolic process (GO:0006244)3.50468348
54mitotic nuclear envelope disassembly (GO:0007077)3.50286918
55regulation of spindle organization (GO:0090224)3.47006345
56establishment of integrated proviral latency (GO:0075713)3.46503167
57termination of RNA polymerase I transcription (GO:0006363)3.44874592
58rRNA metabolic process (GO:0016072)3.44403463
59transcription from RNA polymerase I promoter (GO:0006360)3.44244157
60positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43086552
61transcription elongation from RNA polymerase I promoter (GO:0006362)3.42544758
62tRNA aminoacylation for protein translation (GO:0006418)3.41294525
63regulation of mitochondrial translation (GO:0070129)3.39187782
64cullin deneddylation (GO:0010388)3.39073638
65rRNA methylation (GO:0031167)3.37575572
66amino acid activation (GO:0043038)3.35730336
67tRNA aminoacylation (GO:0043039)3.35730336
68spindle checkpoint (GO:0031577)3.34332956
69folic acid metabolic process (GO:0046655)3.34259341
70DNA ligation (GO:0006266)3.33856857
71mitotic recombination (GO:0006312)3.33075344
72protein localization to chromosome, centromeric region (GO:0071459)3.32852320
73oxidative phosphorylation (GO:0006119)3.31362574
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30170024
75DNA replication-dependent nucleosome organization (GO:0034723)3.29839951
76DNA replication-dependent nucleosome assembly (GO:0006335)3.29839951
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.28717586
78iron-sulfur cluster assembly (GO:0016226)3.27614717
79metallo-sulfur cluster assembly (GO:0031163)3.27614717
80positive regulation of ligase activity (GO:0051351)3.27470958
81chaperone-mediated protein transport (GO:0072321)3.27279786
82establishment of viral latency (GO:0019043)3.26149068
83transcription elongation from RNA polymerase II promoter (GO:0006368)3.24751815
84telomere maintenance via telomere lengthening (GO:0010833)3.23624538
85kinetochore assembly (GO:0051382)3.23589563
86pseudouridine synthesis (GO:0001522)3.23244281
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22230471
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20124943
89negative regulation of sister chromatid segregation (GO:0033046)3.20124943
90negative regulation of mitotic sister chromatid separation (GO:2000816)3.20124943
91negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20124943
92membrane disassembly (GO:0030397)3.19825813
93nuclear envelope disassembly (GO:0051081)3.19825813
94cell cycle G1/S phase transition (GO:0044843)3.19355914
95G1/S transition of mitotic cell cycle (GO:0000082)3.19355914
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19286884
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.19213579
98cellular component biogenesis (GO:0044085)3.19061670
99kinetochore organization (GO:0051383)3.18052656
100mitotic spindle checkpoint (GO:0071174)3.18004885
101negative regulation of chromosome segregation (GO:0051985)3.17471125
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15859889
103signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15859889
104signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15859889
105protein targeting to mitochondrion (GO:0006626)3.14939625
106regulation of cellular amino acid metabolic process (GO:0006521)3.14916130
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14823079
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14823079
109mitotic spindle assembly checkpoint (GO:0007094)3.13989812
110energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12496909
111ATP synthesis coupled proton transport (GO:0015986)3.12496909
112mitochondrial RNA metabolic process (GO:0000959)3.12469017
113regulation of ubiquitin-protein transferase activity (GO:0051438)3.12433949
114pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.12373202
115positive regulation of chromosome segregation (GO:0051984)3.11815405
116signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11554211
117signal transduction involved in DNA damage checkpoint (GO:0072422)3.11554211
118DNA-templated transcription, elongation (GO:0006354)3.11219495
119protein K6-linked ubiquitination (GO:0085020)3.10445743
120ribosomal small subunit biogenesis (GO:0042274)3.10105217
121nucleotide-excision repair, DNA gap filling (GO:0006297)3.09918624
122spindle assembly checkpoint (GO:0071173)3.09886499
123folic acid-containing compound biosynthetic process (GO:0009396)3.09394617
124transcription initiation from RNA polymerase I promoter (GO:0006361)3.09042049
125guanosine-containing compound biosynthetic process (GO:1901070)3.08319924
126signal transduction involved in cell cycle checkpoint (GO:0072395)3.08266575
127regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07917905
128pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07845282
129deoxyribose phosphate biosynthetic process (GO:0046385)3.07041308
1302-deoxyribonucleotide biosynthetic process (GO:0009265)3.07041308
131tRNA metabolic process (GO:0006399)3.05693982
132exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03850107
133DNA catabolic process, exonucleolytic (GO:0000738)3.01486969
134base-excision repair (GO:0006284)3.00874025
135establishment of protein localization to mitochondrial membrane (GO:0090151)3.00532485
136IMP biosynthetic process (GO:0006188)2.99437747
137regulation of ligase activity (GO:0051340)2.99244705
138nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98132997
139protein maturation by protein folding (GO:0022417)2.97969457
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97257987
141mitotic sister chromatid segregation (GO:0000070)2.95182945
142deoxyribonucleotide biosynthetic process (GO:0009263)2.94405394
143* translation (GO:0006412)2.93560121
144tRNA processing (GO:0008033)2.91069337
145mitotic chromosome condensation (GO:0007076)2.90973497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48408451
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36676819
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.29811252
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73951004
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.71812898
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.62275345
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.47615509
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43582999
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.28962831
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23762980
11* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23186365
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16441546
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04620992
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99264195
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92643990
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90320625
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87804639
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66488453
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63436336
20VDR_23849224_ChIP-Seq_CD4+_Human2.57851518
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45280357
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40367544
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39670748
24XRN2_22483619_ChIP-Seq_HELA_Human2.35751497
25DCP1A_22483619_ChIP-Seq_HELA_Human2.31149148
26AR_21909140_ChIP-Seq_LNCAP_Human2.30137498
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26887522
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22403701
29* GABP_19822575_ChIP-Seq_HepG2_Human2.18324908
30FOXP3_21729870_ChIP-Seq_TREG_Human2.14274082
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05475586
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04662114
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04389686
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98390235
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.96835182
36TTF2_22483619_ChIP-Seq_HELA_Human1.91817992
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91722128
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88637399
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87955173
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.87758834
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80360047
42* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77833807
43ELK1_19687146_ChIP-ChIP_HELA_Human1.76082017
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70346474
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.69435277
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65505706
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64264538
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63720658
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56705889
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51552454
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51413755
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48663407
53KDM5A_27292631_Chip-Seq_BREAST_Human1.47354590
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37750134
55CIITA_25753668_ChIP-Seq_RAJI_Human1.34711101
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29605248
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25158281
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25071318
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23288724
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21786466
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21771829
62MYC_18940864_ChIP-ChIP_HL60_Human1.20742924
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20124495
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18868324
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18408983
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17558041
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.17508203
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16245060
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15184112
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14241251
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07742627
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05837616
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.04724603
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.03969474
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02830967
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00194509
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99314398
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99219445
79TFEB_21752829_ChIP-Seq_HELA_Human0.98802679
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97628218
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95142572
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94603845
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93252029
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93111493
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90846764
86MYC_22102868_ChIP-Seq_BL_Human0.90292654
87KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88136245
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87572813
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87557265
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86403853
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.85116727
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84783926
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83277584
94* SPI1_23547873_ChIP-Seq_NB4_Human0.83207834
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83002420
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82365736
97* FOXP1_21924763_ChIP-Seq_HESCs_Human0.82088348
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82065110
99CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81690869
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.81414357
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81352660
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79435955
103* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79050802
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78667521
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78342601
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77623205
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76986784
108IRF1_19129219_ChIP-ChIP_H3396_Human0.75830457
109* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75385653
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75323494
111TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.74412040
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72806462
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72587970
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.72445125
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71863304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.32334783
2MP0004957_abnormal_blastocyst_morpholog4.75914759
3MP0003111_abnormal_nucleus_morphology4.74866381
4MP0010094_abnormal_chromosome_stability4.65957478
5MP0003077_abnormal_cell_cycle4.15518382
6MP0003718_maternal_effect3.79301637
7MP0008058_abnormal_DNA_repair3.48352609
8MP0008057_abnormal_DNA_replication3.22098633
9MP0008932_abnormal_embryonic_tissue3.02962467
10MP0003123_paternal_imprinting2.82016170
11MP0008007_abnormal_cellular_replicative2.81727029
12MP0008877_abnormal_DNA_methylation2.42252078
13MP0003806_abnormal_nucleotide_metabolis2.41250276
14MP0003786_premature_aging2.33712592
15MP0001730_embryonic_growth_arrest2.22767878
16MP0008260_abnormal_autophagy2.08913978
17MP0002396_abnormal_hematopoietic_system1.98329499
18MP0000350_abnormal_cell_proliferation1.92244766
19MP0003315_abnormal_perineum_morphology1.80180489
20MP0006292_abnormal_olfactory_placode1.73347649
21MP0003186_abnormal_redox_activity1.63538257
22MP0005451_abnormal_body_composition1.60170408
23MP0001697_abnormal_embryo_size1.58458589
24MP0000490_abnormal_crypts_of1.57497208
25MP0001672_abnormal_embryogenesis/_devel1.57440297
26MP0005380_embryogenesis_phenotype1.57440297
27MP0009333_abnormal_splenocyte_physiolog1.54798106
28MP0000372_irregular_coat_pigmentation1.53769106
29MP0002102_abnormal_ear_morphology1.53722786
30MP0002210_abnormal_sex_determination1.53095630
31MP0008995_early_reproductive_senescence1.49132468
32MP0002080_prenatal_lethality1.39715848
33MP0003984_embryonic_growth_retardation1.34923315
34MP0005501_abnormal_skin_physiology1.34374962
35MP0001929_abnormal_gametogenesis1.34304480
36MP0000313_abnormal_cell_death1.32615223
37MP0000653_abnormal_sex_gland1.31940728
38MP0001853_heart_inflammation1.31341457
39MP0002088_abnormal_embryonic_growth/wei1.30829804
40MP0001119_abnormal_female_reproductive1.30551686
41MP0005499_abnormal_olfactory_system1.28754586
42MP0005394_taste/olfaction_phenotype1.28754586
43MP0002085_abnormal_embryonic_tissue1.28549875
44MP0005395_other_phenotype1.28226254
45MP0001145_abnormal_male_reproductive1.27498318
46MP0002132_abnormal_respiratory_system1.27358621
47MP0010307_abnormal_tumor_latency1.26940862
48MP0002019_abnormal_tumor_incidence1.25485846
49MP0002877_abnormal_melanocyte_morpholog1.24945212
50MP0005408_hypopigmentation1.20575469
51MP0004147_increased_porphyrin_level1.20431073
52MP0006036_abnormal_mitochondrial_physio1.18764875
53MP0003646_muscle_fatigue1.18651843
54MP0003656_abnormal_erythrocyte_physiolo1.18044914
55MP0009278_abnormal_bone_marrow1.09835462
56MP0006035_abnormal_mitochondrial_morpho1.09243083
57MP0003121_genomic_imprinting1.07243056
58MP0003567_abnormal_fetal_cardiomyocyte1.05038641
59MP0002160_abnormal_reproductive_system1.04388188
60MP0000358_abnormal_cell_content/1.03508314
61MP0002653_abnormal_ependyma_morphology1.02865894
62MP0002084_abnormal_developmental_patter1.01990010
63MP0004233_abnormal_muscle_weight1.00593850
64MP0005389_reproductive_system_phenotype0.99629138
65MP0002086_abnormal_extraembryonic_tissu0.99551399
66MP0001529_abnormal_vocalization0.98734087
67MP0003699_abnormal_female_reproductive0.97004113
68MP0009697_abnormal_copulation0.96671402
69MP0003221_abnormal_cardiomyocyte_apopto0.96540817
70MP0001881_abnormal_mammary_gland0.95636495
71MP0010352_gastrointestinal_tract_polyps0.89905688
72MP0003937_abnormal_limbs/digits/tail_de0.88861696
73MP0002796_impaired_skin_barrier0.87563504
74MP0005397_hematopoietic_system_phenotyp0.86126090
75MP0001545_abnormal_hematopoietic_system0.86126090
76MP0010030_abnormal_orbit_morphology0.85898792
77MP0005075_abnormal_melanosome_morpholog0.84923725
78MP0001919_abnormal_reproductive_system0.80510534
79MP0001764_abnormal_homeostasis0.80007228
80MP0003890_abnormal_embryonic-extraembry0.79276637
81MP0005384_cellular_phenotype0.77896480
82MP0000566_synostosis0.76872595
83MP0000647_abnormal_sebaceous_gland0.75199908
84MP0002429_abnormal_blood_cell0.72662398
85MP0002938_white_spotting0.72586368
86MP0001542_abnormal_bone_strength0.71329318
87MP0003119_abnormal_digestive_system0.70605587
88MP0009379_abnormal_foot_pigmentation0.70563506
89MP0002161_abnormal_fertility/fecundity0.68824184
90MP0008789_abnormal_olfactory_epithelium0.68216385
91MP0004808_abnormal_hematopoietic_stem0.68181121
92MP0005379_endocrine/exocrine_gland_phen0.68016583
93MP0005621_abnormal_cell_physiology0.67984566
94MP0001293_anophthalmia0.67929194
95MP0004197_abnormal_fetal_growth/weight/0.66732068
96MP0003763_abnormal_thymus_physiology0.65761921
97MP0002722_abnormal_immune_system0.64403002
98MP0000689_abnormal_spleen_morphology0.63978503
99MP0000703_abnormal_thymus_morphology0.63000033
100MP0001727_abnormal_embryo_implantation0.60627611
101MP0009840_abnormal_foam_cell0.60081200
102MP0001661_extended_life_span0.59419749
103MP0000049_abnormal_middle_ear0.58573065
104MP0004782_abnormal_surfactant_physiolog0.57795984
105MP0003698_abnormal_male_reproductive0.56790848
106MP0002111_abnormal_tail_morphology0.56749880
107MP0008873_increased_physiological_sensi0.56642382
108MP0002398_abnormal_bone_marrow0.56377990
109MP0009672_abnormal_birth_weight0.56290100
110MP0002095_abnormal_skin_pigmentation0.56260073
111MP0005332_abnormal_amino_acid0.55462419
112MP0004264_abnormal_extraembryonic_tissu0.54951311
113MP0003950_abnormal_plasma_membrane0.54010486
114MP0003136_yellow_coat_color0.53610653
115MP0005636_abnormal_mineral_homeostasis0.53472318
116MP0000598_abnormal_liver_morphology0.53130619
117MP0001905_abnormal_dopamine_level0.52723429
118MP0002009_preneoplasia0.52474235
119MP0002163_abnormal_gland_morphology0.52271322
120MP0003938_abnormal_ear_development0.51380307
121MP0005319_abnormal_enzyme/_coenzyme0.51369141
122MP0000750_abnormal_muscle_regeneration0.49065100
123MP0005266_abnormal_metabolism0.48738745

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.13107997
2Breast hypoplasia (HP:0003187)5.21460011
3Carpal bone hypoplasia (HP:0001498)3.85502095
4Microvesicular hepatic steatosis (HP:0001414)3.72329822
5Patellar aplasia (HP:0006443)3.70090411
6Abnormality of cells of the erythroid lineage (HP:0012130)3.54276256
7Oral leukoplakia (HP:0002745)3.52258064
8Aplasia/Hypoplasia of the patella (HP:0006498)3.51613855
9Rough bone trabeculation (HP:0100670)3.48908430
10Degeneration of anterior horn cells (HP:0002398)3.46344369
11Abnormality of the anterior horn cell (HP:0006802)3.46344369
12Abnormal protein glycosylation (HP:0012346)3.41344915
13Abnormal glycosylation (HP:0012345)3.41344915
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.41344915
15Abnormal protein N-linked glycosylation (HP:0012347)3.41344915
16Abnormal number of erythroid precursors (HP:0012131)3.40868682
17Aplastic anemia (HP:0001915)3.34361150
18Cerebral edema (HP:0002181)3.32728297
19Reticulocytopenia (HP:0001896)3.31007858
20Progressive macrocephaly (HP:0004481)3.29616705
21Ragged-red muscle fibers (HP:0003200)3.27040698
22* Cerebral hypomyelination (HP:0006808)3.25331373
23Abnormality of the preputium (HP:0100587)3.19309871
24Lactic acidosis (HP:0003128)3.16203414
25Chromsome breakage (HP:0040012)3.16123451
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05374077
27Abnormality of the labia minora (HP:0012880)3.04278528
28Meckel diverticulum (HP:0002245)2.99163427
29Microretrognathia (HP:0000308)2.96679218
30Increased intramyocellular lipid droplets (HP:0012240)2.94892396
31Abnormality of glycolysis (HP:0004366)2.88232605
32Increased serum pyruvate (HP:0003542)2.88232605
33Abnormality of chromosome stability (HP:0003220)2.85209320
34Progressive microcephaly (HP:0000253)2.84400949
35Absent radius (HP:0003974)2.82633907
36Abnormality of the ileum (HP:0001549)2.81903904
37Impulsivity (HP:0100710)2.77774620
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.74252724
39Increased muscle lipid content (HP:0009058)2.73468008
40Exercise intolerance (HP:0003546)2.66008439
41Absent thumb (HP:0009777)2.64230118
42Hepatocellular necrosis (HP:0001404)2.63917705
43Absent forearm bone (HP:0003953)2.63733314
44Aplasia involving forearm bones (HP:0009822)2.63733314
45Abnormal trabecular bone morphology (HP:0100671)2.62868870
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.62396705
47Abnormality of alanine metabolism (HP:0010916)2.60392808
48Hyperalaninemia (HP:0003348)2.60392808
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60392808
50Macrocytic anemia (HP:0001972)2.57899336
51* Secondary amenorrhea (HP:0000869)2.55717902
52Irregular epiphyses (HP:0010582)2.54774266
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53371714
54Bone marrow hypocellularity (HP:0005528)2.52599910
55Respiratory failure (HP:0002878)2.52341897
56Multiple enchondromatosis (HP:0005701)2.51640212
57Small intestinal stenosis (HP:0012848)2.49678280
58Duodenal stenosis (HP:0100867)2.49678280
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47489322
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47489322
61Increased serum lactate (HP:0002151)2.47085322
623-Methylglutaconic aciduria (HP:0003535)2.43205142
63Trismus (HP:0000211)2.40995946
64Horseshoe kidney (HP:0000085)2.39805704
65Severe combined immunodeficiency (HP:0004430)2.38897534
66Aplasia/Hypoplasia involving the musculature (HP:0001460)2.38314836
67Increased CSF lactate (HP:0002490)2.36632596
68Hepatic necrosis (HP:0002605)2.35905470
69Abnormal lung lobation (HP:0002101)2.34122716
70Testicular atrophy (HP:0000029)2.32816561
71Myelodysplasia (HP:0002863)2.32301273
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31543177
73Premature graying of hair (HP:0002216)2.31028967
74Increased hepatocellular lipid droplets (HP:0006565)2.30668179
75Mitochondrial inheritance (HP:0001427)2.29459382
76Abnormal spermatogenesis (HP:0008669)2.29244187
77Sparse eyelashes (HP:0000653)2.29182714
78Colon cancer (HP:0003003)2.28619832
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26957552
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26905546
81Reduced antithrombin III activity (HP:0001976)2.26524755
82Combined immunodeficiency (HP:0005387)2.24858632
83Acute necrotizing encephalopathy (HP:0006965)2.24468169
84Selective tooth agenesis (HP:0001592)2.24213146
85Abnormality of the umbilical cord (HP:0010881)2.23381536
86Triphalangeal thumb (HP:0001199)2.23131304
87Sloping forehead (HP:0000340)2.22731713
88Respiratory difficulties (HP:0002880)2.21608736
89Squamous cell carcinoma (HP:0002860)2.20232022
90Ureteral duplication (HP:0000073)2.16700280
91Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16127118
92Cellular immunodeficiency (HP:0005374)2.15596836
93Renal Fanconi syndrome (HP:0001994)2.15511476
94Entropion (HP:0000621)2.14946877
95Type I transferrin isoform profile (HP:0003642)2.11942176
96Medulloblastoma (HP:0002885)2.11342348
97Optic disc pallor (HP:0000543)2.09632799
98IgM deficiency (HP:0002850)2.08265518
99Supernumerary spleens (HP:0009799)2.07900271
100Lipid accumulation in hepatocytes (HP:0006561)2.07356312
101Cleft eyelid (HP:0000625)2.07257191
102* Lethargy (HP:0001254)2.06769386
103Pallor (HP:0000980)2.06144124
104* Premature ovarian failure (HP:0008209)2.06138801
105Dicarboxylic aciduria (HP:0003215)2.05642385
106Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05642385
107Hypergonadotropic hypogonadism (HP:0000815)2.05090401
108Hyperglycinemia (HP:0002154)2.02397805
109Adrenal hypoplasia (HP:0000835)2.01704869
110Male infertility (HP:0003251)2.01212972
111Exertional dyspnea (HP:0002875)2.00808733
112Stenosis of the external auditory canal (HP:0000402)2.00134127
113Abnormal mitochondria in muscle tissue (HP:0008316)1.99147995
114Abnormality of the duodenum (HP:0002246)1.98605422
115Muscle fiber atrophy (HP:0100295)1.98346344
116Pancytopenia (HP:0001876)1.98094625
117Neoplasm of the pancreas (HP:0002894)1.97990729
118Type 2 muscle fiber atrophy (HP:0003554)1.97921910
119Poor head control (HP:0002421)1.94923243
120Leukodystrophy (HP:0002415)1.94258721
121Abnormality of DNA repair (HP:0003254)1.93170610
122Agnosia (HP:0010524)1.92553097
123Breast aplasia (HP:0100783)1.91950038
124Acute hepatic failure (HP:0006554)1.91715869
125Megaloblastic anemia (HP:0001889)1.90850089
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.90184050
127* Emotional lability (HP:0000712)1.89990200
128Progressive muscle weakness (HP:0003323)1.89618263
129Aplasia/Hypoplasia of the breasts (HP:0010311)1.88797545
130Atrophy/Degeneration involving motor neurons (HP:0007373)1.88269094
131Acute encephalopathy (HP:0006846)1.87298349
132* CNS hypomyelination (HP:0003429)1.86819468
133* CNS demyelination (HP:0007305)1.86313787
134Seborrheic dermatitis (HP:0001051)1.85129948
135Abnormality of serum amino acid levels (HP:0003112)1.82150144
136Aplasia/Hypoplasia of the thymus (HP:0010515)1.81808430
137Opisthotonus (HP:0002179)1.78433947
138Hypokinesia (HP:0002375)1.78363288
139* Postnatal microcephaly (HP:0005484)1.78251350
140Hypertensive crisis (HP:0100735)1.75823120
141Aplasia/hypoplasia of the uterus (HP:0008684)1.75604222
142Abnormality of lateral ventricle (HP:0030047)1.74817122
143Truncus arteriosus (HP:0001660)1.74710016
144Tinnitus (HP:0000360)1.74573151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.69851718
2EIF2AK14.37513755
3WEE13.99946827
4PLK43.42252345
5VRK23.10895489
6CDC72.78697817
7TTK2.74677183
8STK162.66997862
9SRPK12.52691066
10TRIM282.51125701
11NME22.47462247
12EIF2AK32.35701224
13BRSK22.30675488
14TSSK62.27909407
15ACVR1B2.24594104
16NEK22.18661942
17NEK12.08579675
18PLK12.06273526
19VRK11.89038097
20PLK31.76316859
21BRAF1.69600798
22CCNB11.63430720
23TESK21.62169905
24SIK31.61651115
25AURKB1.56158703
26STK38L1.47350495
27CHEK21.43918583
28MKNK11.42811514
29TLK11.41238034
30CDK71.36103641
31DYRK31.33159901
32AURKA1.32052993
33MKNK21.31624420
34BRSK11.31412349
35ZAK1.27806880
36MAP4K21.26486836
37AKT31.23604867
38DYRK21.19050927
39ATR1.15544983
40EPHA21.14641287
41PIM21.13982761
42ARAF1.12351462
43CDK81.11126144
44MAP3K81.10765861
45RPS6KB21.07134587
46NME11.06380643
47MAP3K121.06204260
48BCKDK1.03450175
49RPS6KA41.00679818
50PBK1.00459366
51LATS20.94305810
52DAPK10.92195096
53BMPR20.91213610
54CHEK10.87049069
55MOS0.82590819
56CDK40.80631291
57PASK0.74283142
58STK100.73726913
59MELK0.72830879
60EIF2AK20.72580851
61PDK30.72021077
62PDK40.72021077
63PRKCI0.67904437
64STK30.67518321
65CSNK2A10.66608340
66PDK20.64391658
67MAP3K60.63714886
68PAK10.63639572
69MAPKAPK50.61459983
70NUAK10.60884094
71ILK0.60785239
72IRAK30.59826183
73STK40.59425190
74ABL20.58972001
75ATM0.58395851
76CSNK2A20.58039132
77LRRK20.57504440
78MAP2K70.56862642
79RAF10.55654125
80CDK20.55445124
81PIM10.54941955
82MAPKAPK30.54813617
83MARK30.54520877
84CSNK1G30.54163466
85CDK60.52752884
86MST40.51765530
87KDR0.50486204
88LATS10.50211508
89PNCK0.49537605
90CDK190.48867575
91CLK10.47625118
92MUSK0.46243993
93CDK10.44654757
94LIMK10.44279287
95TGFBR10.42772048
96PAK40.42102699
97CSNK1G10.41751761
98ERBB30.40197073
99STK240.39607196
100RPS6KA50.38225833
101CDK30.35461491
102MAP3K50.35419350
103CSNK1G20.34610345
104PINK10.34588682
105NEK90.32599385
106TESK10.31058655
107ERBB40.29934564
108GRK60.29603167
109AKT20.28517420
110MAPK110.27251947
111CDK90.26080957
112CDK140.25817054
113IRAK40.24808524
114MAP3K110.24643787
115TAOK30.24155646
116IRAK20.23966526
117NLK0.23450909
118SCYL20.22682827
119TBK10.22368824
120CSNK1A1L0.21999740
121MAP4K10.21749499
122CSNK1E0.21053822
123OBSCN0.20449168
124PRKDC0.19719400
125MAP3K30.19651152
126BCR0.16729207

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.38992366
2DNA replication_Homo sapiens_hsa030304.16187794
3Proteasome_Homo sapiens_hsa030504.07649734
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.81300126
5Mismatch repair_Homo sapiens_hsa034303.51583119
6Ribosome_Homo sapiens_hsa030103.33688086
7* RNA transport_Homo sapiens_hsa030132.93540791
8Pyrimidine metabolism_Homo sapiens_hsa002402.85665145
9Spliceosome_Homo sapiens_hsa030402.83742250
10Homologous recombination_Homo sapiens_hsa034402.82918457
11Nucleotide excision repair_Homo sapiens_hsa034202.74307118
12Base excision repair_Homo sapiens_hsa034102.71187733
13Cell cycle_Homo sapiens_hsa041102.66488291
14Basal transcription factors_Homo sapiens_hsa030222.54941895
15Vitamin B6 metabolism_Homo sapiens_hsa007502.50963462
16Fanconi anemia pathway_Homo sapiens_hsa034602.10264154
17RNA degradation_Homo sapiens_hsa030182.08736254
18One carbon pool by folate_Homo sapiens_hsa006701.96122984
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93023605
20Non-homologous end-joining_Homo sapiens_hsa034501.84457227
21Purine metabolism_Homo sapiens_hsa002301.70277974
22Folate biosynthesis_Homo sapiens_hsa007901.66747344
23Protein export_Homo sapiens_hsa030601.54904920
24p53 signaling pathway_Homo sapiens_hsa041151.47723474
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29026376
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25369892
27mRNA surveillance pathway_Homo sapiens_hsa030151.25056650
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.22261268
29Oxidative phosphorylation_Homo sapiens_hsa001901.14200165
30Epstein-Barr virus infection_Homo sapiens_hsa051691.12967601
31Huntingtons disease_Homo sapiens_hsa050161.11340299
32Regulation of autophagy_Homo sapiens_hsa041401.09187898
33Parkinsons disease_Homo sapiens_hsa050121.09108056
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05078666
35Oocyte meiosis_Homo sapiens_hsa041141.04236867
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02703315
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00499272
38Pentose phosphate pathway_Homo sapiens_hsa000301.00401150
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.99715772
40Propanoate metabolism_Homo sapiens_hsa006400.93694639
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93622995
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92242145
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86292086
44Biosynthesis of amino acids_Homo sapiens_hsa012300.85851802
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84754341
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83365024
47Glutathione metabolism_Homo sapiens_hsa004800.78159945
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73274858
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71612421
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68680261
51Sulfur relay system_Homo sapiens_hsa041220.66999424
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59085623
53Sulfur metabolism_Homo sapiens_hsa009200.58128768
54Metabolic pathways_Homo sapiens_hsa011000.58082596
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.54697977
56Peroxisome_Homo sapiens_hsa041460.53693639
57Arachidonic acid metabolism_Homo sapiens_hsa005900.53587502
58Linoleic acid metabolism_Homo sapiens_hsa005910.52980499
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52818268
60Carbon metabolism_Homo sapiens_hsa012000.51984214
61Herpes simplex infection_Homo sapiens_hsa051680.51550531
62Fructose and mannose metabolism_Homo sapiens_hsa000510.51504938
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51377385
64Selenocompound metabolism_Homo sapiens_hsa004500.50722378
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49399042
66Systemic lupus erythematosus_Homo sapiens_hsa053220.45547228
67Viral carcinogenesis_Homo sapiens_hsa052030.45020960
68Antigen processing and presentation_Homo sapiens_hsa046120.44539543
69Alzheimers disease_Homo sapiens_hsa050100.44323784
70Fatty acid metabolism_Homo sapiens_hsa012120.42885408
71Thyroid cancer_Homo sapiens_hsa052160.41278764
72Arginine and proline metabolism_Homo sapiens_hsa003300.39786007
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38675979
74N-Glycan biosynthesis_Homo sapiens_hsa005100.35989067
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34309104
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34242038
77HTLV-I infection_Homo sapiens_hsa051660.30724182
78Galactose metabolism_Homo sapiens_hsa000520.26004683
79Ether lipid metabolism_Homo sapiens_hsa005650.25678701
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.25395452
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24105682
82Cardiac muscle contraction_Homo sapiens_hsa042600.23177053
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23005199
84Vitamin digestion and absorption_Homo sapiens_hsa049770.22945576
85TGF-beta signaling pathway_Homo sapiens_hsa043500.22545000
86Steroid biosynthesis_Homo sapiens_hsa001000.22394321
87Phenylalanine metabolism_Homo sapiens_hsa003600.21598108
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21114203
89Legionellosis_Homo sapiens_hsa051340.20936542
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20108830
91Vibrio cholerae infection_Homo sapiens_hsa051100.19823143
92Tyrosine metabolism_Homo sapiens_hsa003500.17652049
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16213470
94Sphingolipid metabolism_Homo sapiens_hsa006000.16188591
95Circadian rhythm_Homo sapiens_hsa047100.15897678
96Collecting duct acid secretion_Homo sapiens_hsa049660.15502619
97Pyruvate metabolism_Homo sapiens_hsa006200.15382524
98Arginine biosynthesis_Homo sapiens_hsa002200.15145880
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14882729
100Apoptosis_Homo sapiens_hsa042100.11535868
101MicroRNAs in cancer_Homo sapiens_hsa052060.11333096
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11022088
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.10588707
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10098732
105Hippo signaling pathway_Homo sapiens_hsa043900.09202484
106Small cell lung cancer_Homo sapiens_hsa052220.08431920
107beta-Alanine metabolism_Homo sapiens_hsa004100.05885291
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.04207291
109Shigellosis_Homo sapiens_hsa051310.03888034
110Butanoate metabolism_Homo sapiens_hsa006500.03730274
111Other glycan degradation_Homo sapiens_hsa005110.03416359
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.02764386
113Fatty acid elongation_Homo sapiens_hsa000620.02335060
114Phototransduction_Homo sapiens_hsa047440.02308582
115Renin-angiotensin system_Homo sapiens_hsa046140.02230270
116HIF-1 signaling pathway_Homo sapiens_hsa040660.01381816
117Transcriptional misregulation in cancer_Homo sapiens_hsa05202-0.0672545
118FoxO signaling pathway_Homo sapiens_hsa04068-0.0427331
119Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0408053
120Bladder cancer_Homo sapiens_hsa05219-0.0404069
121Primary immunodeficiency_Homo sapiens_hsa05340-0.0177125
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0171858
123Colorectal cancer_Homo sapiens_hsa05210-0.0026422

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