EIF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.56926816
2viral transcription (GO:0019083)5.37301978
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.35972536
4protein targeting to ER (GO:0045047)5.22583263
5cotranslational protein targeting to membrane (GO:0006613)5.21398219
6translational termination (GO:0006415)5.16537862
7establishment of protein localization to endoplasmic reticulum (GO:0072599)4.95629766
8protein localization to endoplasmic reticulum (GO:0070972)4.92751772
9Golgi transport vesicle coating (GO:0048200)4.82284935
10COPI coating of Golgi vesicle (GO:0048205)4.82284935
11translational elongation (GO:0006414)4.68874809
12signal peptide processing (GO:0006465)4.63641963
13DNA deamination (GO:0045006)4.60455419
14viral life cycle (GO:0019058)4.42842213
15ribosomal small subunit biogenesis (GO:0042274)4.20931850
16tolerance induction (GO:0002507)4.20008721
17protein maturation by protein folding (GO:0022417)4.19402257
18cellular protein complex disassembly (GO:0043624)4.15575415
19maturation of SSU-rRNA (GO:0030490)4.13336789
20* translational initiation (GO:0006413)4.12330165
21L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.09316265
22ribosomal large subunit biogenesis (GO:0042273)4.07508543
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.90806970
24translation (GO:0006412)3.87066510
25regulation of chronic inflammatory response (GO:0002676)3.74621897
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65086494
27proteasome assembly (GO:0043248)3.63508953
28protein targeting to membrane (GO:0006612)3.58711930
29protein complex disassembly (GO:0043241)3.52690280
30negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.49415565
31positive regulation of granulocyte differentiation (GO:0030854)3.48713457
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.42790668
33ATP synthesis coupled proton transport (GO:0015986)3.42790668
34macromolecular complex disassembly (GO:0032984)3.42749394
35protein complex biogenesis (GO:0070271)3.39296861
36regulation of mitochondrial translation (GO:0070129)3.39223592
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.38800966
38termination of RNA polymerase III transcription (GO:0006386)3.38800966
39regulation of isotype switching to IgG isotypes (GO:0048302)3.38563324
40viral protein processing (GO:0019082)3.37118313
41respiratory electron transport chain (GO:0022904)3.36613910
42electron transport chain (GO:0022900)3.31797720
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31650033
44negative regulation of glycoprotein biosynthetic process (GO:0010561)3.28618213
45GDP-mannose metabolic process (GO:0019673)3.28305275
46cullin deneddylation (GO:0010388)3.24801730
47ribonucleoprotein complex biogenesis (GO:0022613)3.24396252
48virion assembly (GO:0019068)3.23002176
49protein deneddylation (GO:0000338)3.18420620
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18303124
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17906990
52formation of translation preinitiation complex (GO:0001731)3.14944570
53negative regulation of cell killing (GO:0031342)3.12882716
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12882716
55NADH metabolic process (GO:0006734)3.12583698
56mitochondrial respiratory chain complex assembly (GO:0033108)3.11293675
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.11110892
58cellular component biogenesis (GO:0044085)3.10175370
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06901709
60L-methionine salvage (GO:0071267)2.98584519
61L-methionine biosynthetic process (GO:0071265)2.98584519
62amino acid salvage (GO:0043102)2.98584519
63peptidyl-histidine modification (GO:0018202)2.98364799
64T-helper cell differentiation (GO:0042093)2.95438081
65CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.95438081
66guanosine-containing compound biosynthetic process (GO:1901070)2.95279954
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91935524
68antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.90912494
69oxidative phosphorylation (GO:0006119)2.89157767
70pteridine-containing compound biosynthetic process (GO:0042559)2.88520410
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86202205
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.86202205
73NADH dehydrogenase complex assembly (GO:0010257)2.86202205
74protein K11-linked ubiquitination (GO:0070979)2.84011138
75rRNA modification (GO:0000154)2.83347969
76iron-sulfur cluster assembly (GO:0016226)2.83305396
77metallo-sulfur cluster assembly (GO:0031163)2.83305396
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83229596
79negative regulation of ligase activity (GO:0051352)2.83229596
80nuclear-transcribed mRNA catabolic process (GO:0000956)2.83202968
81protein retention in ER lumen (GO:0006621)2.82538979
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81914637
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81914637
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81808746
85positive regulation of mitochondrial fission (GO:0090141)2.81731316
86response to muramyl dipeptide (GO:0032495)2.81582553
87interferon-gamma production (GO:0032609)2.80485477
88NIK/NF-kappaB signaling (GO:0038061)2.79582114
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79498604
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78863503
91sequestering of actin monomers (GO:0042989)2.78011911
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77266998
93neutrophil activation involved in immune response (GO:0002283)2.74654339
94RNA destabilization (GO:0050779)2.74567597
95positive regulation of DNA recombination (GO:0045911)2.73520361
96positive regulation of ligase activity (GO:0051351)2.73511468
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72493859
98regulation of regulatory T cell differentiation (GO:0045589)2.70727305
99mRNA catabolic process (GO:0006402)2.69580728
100oxaloacetate metabolic process (GO:0006107)2.67776032
101establishment of protein localization to membrane (GO:0090150)2.66450377
102spliceosomal snRNP assembly (GO:0000387)2.65297190
103regulation of cellular amino acid metabolic process (GO:0006521)2.64691721
104antigen processing and presentation of endogenous antigen (GO:0019883)2.64493275
105energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.64343790
106ATP hydrolysis coupled proton transport (GO:0015991)2.64343790
107mast cell activation (GO:0045576)2.64272896
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63714897
109ribosome biogenesis (GO:0042254)2.63564049
110alpha-beta T cell differentiation involved in immune response (GO:0002293)2.63209817
111alpha-beta T cell activation involved in immune response (GO:0002287)2.63209817
112T cell differentiation involved in immune response (GO:0002292)2.63209817
113negative regulation of T cell mediated immunity (GO:0002710)2.62566678
114respiratory chain complex IV assembly (GO:0008535)2.62099815
115regulation of immunoglobulin secretion (GO:0051023)2.61168954
116Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60539157
117negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.59249539
118nucleobase-containing small molecule interconversion (GO:0015949)2.57719093
119protein neddylation (GO:0045116)2.56214263
120GTP biosynthetic process (GO:0006183)2.55942728
121chaperone mediated protein folding requiring cofactor (GO:0051085)2.55879407
122cytochrome complex assembly (GO:0017004)2.55342448
123spliceosomal complex assembly (GO:0000245)2.54333725
124chaperone-mediated protein transport (GO:0072321)2.54278129
125negative T cell selection (GO:0043383)2.54043918
126heme biosynthetic process (GO:0006783)2.53956335
127positive regulation of natural killer cell differentiation (GO:0032825)2.53405442
128regulation of germinal center formation (GO:0002634)2.53306144
129negative thymic T cell selection (GO:0045060)2.53217733
130signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.52927226
131intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.52927226
132pseudouridine synthesis (GO:0001522)2.52807777
133de novo protein folding (GO:0006458)2.51990356
134positive regulation of isotype switching (GO:0045830)2.51660516
135autophagic vacuole fusion (GO:0000046)2.51494561
136regulation of inflammatory response to antigenic stimulus (GO:0002861)2.51287149
137positive regulation of gamma-delta T cell activation (GO:0046645)2.49904553
138rRNA processing (GO:0006364)2.49889403
139nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.47154693
140positive regulation of protein homooligomerization (GO:0032464)2.45133971
141defense response to protozoan (GO:0042832)2.44983344
142neutrophil activation (GO:0042119)2.43861538
143positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.42528520
144alpha-beta T cell activation (GO:0046631)2.38713081
145regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.38236620
146positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.37908016
147piRNA metabolic process (GO:0034587)2.36865712
148positive regulation of interleukin-17 production (GO:0032740)2.36660752
149regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.35897636
150regulation of B cell receptor signaling pathway (GO:0050855)2.35778490
151regulation of alpha-beta T cell proliferation (GO:0046640)2.35655751
152phagosome maturation (GO:0090382)2.35512377
153negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.35170767
154positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.34170849
155response to protozoan (GO:0001562)2.34130895
156alpha-beta T cell differentiation (GO:0046632)2.33687347
157organelle membrane fusion (GO:0090174)2.33516422
158negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.33134712
159negative regulation of T-helper cell differentiation (GO:0045623)2.33134712
160CD4-positive, alpha-beta T cell activation (GO:0035710)2.31994727
161antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31727318
162CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.31011662
163I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.30639270
164negative regulation of acute inflammatory response (GO:0002674)2.30399454
165regulation of vacuole organization (GO:0044088)2.28714316
166granulocyte activation (GO:0036230)2.27123007
167protein-cofactor linkage (GO:0018065)2.25275086
168regulation of T cell mediated cytotoxicity (GO:0001914)2.24667420
169platelet dense granule organization (GO:0060155)2.24009424
170CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.23394124
171negative regulation of innate immune response (GO:0045824)2.23288839
172sleep (GO:0030431)2.23180943
173negative regulation of bone resorption (GO:0045779)2.21093739
174actin nucleation (GO:0045010)2.21071615
175positive regulation of immunoglobulin mediated immune response (GO:0002891)2.21046868
176positive regulation of B cell mediated immunity (GO:0002714)2.21046868
177regulation of T-helper 1 cell differentiation (GO:0045625)2.20543601
178regulation of T-helper cell differentiation (GO:0045622)2.19229820
179regulation of granulocyte differentiation (GO:0030852)2.18078135
180leukocyte degranulation (GO:0043299)2.16575533
181positive regulation of interleukin-2 production (GO:0032743)2.16299371
182purinergic nucleotide receptor signaling pathway (GO:0035590)2.16250280
183cellular response to interleukin-15 (GO:0071350)2.15310814
184negative regulation of nitric oxide biosynthetic process (GO:0045019)2.15268130
185transferrin transport (GO:0033572)2.14286218
186positive regulation of alpha-beta T cell proliferation (GO:0046641)2.14093717
187mast cell activation involved in immune response (GO:0002279)2.13993273
188mast cell degranulation (GO:0043303)2.13993273
189regulation of defense response to virus by host (GO:0050691)2.13761223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10704219
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.65865660
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.49726259
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.45899846
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34739770
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33078927
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19590651
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16339928
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12417883
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.11568527
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.11246676
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10156423
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71056932
14* XRN2_22483619_ChIP-Seq_HELA_Human2.59687605
15* DCP1A_22483619_ChIP-Seq_HELA_Human2.52028574
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49025240
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.48887944
18VDR_23849224_ChIP-Seq_CD4+_Human2.46716482
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.43358811
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34835097
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15818816
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14353905
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13336945
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08941131
25* GABP_19822575_ChIP-Seq_HepG2_Human2.07193560
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06354047
27RUNX_20019798_ChIP-Seq_JUKART_Human2.05553144
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03047145
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02455175
30TTF2_22483619_ChIP-Seq_HELA_Human2.01536977
31* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.99041780
32MYC_22102868_ChIP-Seq_BL_Human1.93943628
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88897535
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87179058
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.85531654
36* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85411849
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.84695425
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83670124
39* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76978858
40* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75274588
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.71306468
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.71208402
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.70327598
44ZNF263_19887448_ChIP-Seq_K562_Human1.69845012
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69149392
46* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68268683
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64480349
48ELK1_19687146_ChIP-ChIP_HELA_Human1.64006467
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.57734153
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56292665
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55684345
52* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54770178
53* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54717874
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54372566
55MYB_26560356_Chip-Seq_TH1_Human1.53636416
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51958947
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.49053617
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48699110
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.46952085
60GATA3_26560356_Chip-Seq_TH2_Human1.46845302
61TFEB_21752829_ChIP-Seq_HELA_Human1.41437981
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.40681303
63GATA3_27048872_Chip-Seq_THYMUS_Human1.40659018
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39440882
65* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39215667
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38032113
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37923622
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37106180
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36148844
70* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35670232
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33848769
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.32381532
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32356529
74* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31107649
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29160364
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29026846
77BCL6_27268052_Chip-Seq_Bcells_Human1.27897227
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27386315
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.26880323
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26072484
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24747179
82* ATF3_27146783_Chip-Seq_COLON_Human1.23946583
83CIITA_25753668_ChIP-Seq_RAJI_Human1.21746519
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21372989
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20540369
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20145546
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19108371
88SPI1_23547873_ChIP-Seq_NB4_Human1.16201026
89STAT1_20625510_ChIP-Seq_HELA_Human1.15576983
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15546414
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14287422
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14207275
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13240779
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12907777
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12052392
96* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12005213
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11799436
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11768039
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11403733
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.10859297
101* KDM5A_27292631_Chip-Seq_BREAST_Human1.10547660
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10137537
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09838172
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09679296
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08347387
106MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08160607
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07583183
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07072065
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05179225
110MAF_26560356_Chip-Seq_TH2_Human1.04077068
111BCOR_27268052_Chip-Seq_Bcells_Human1.03497979
112* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03480670
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00950152
114* MAF_26560356_Chip-Seq_TH1_Human1.00321936
115MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00181252
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99863090
117VDR_21846776_ChIP-Seq_THP-1_Human0.99834384
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98744247
119VDR_24763502_ChIP-Seq_THP-1_Human0.98208694
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97211797
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97046113
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96058882
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95934326
124* MYB_26560356_Chip-Seq_TH2_Human0.95913031
125IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95770899
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94990146
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94863982
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94373353
129CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94017652
130P300_27268052_Chip-Seq_Bcells_Human0.93805631
131TP53_22573176_ChIP-Seq_HFKS_Human0.93360634
132EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93261387
133E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93130274
134SCL_19346495_ChIP-Seq_HPC-7_Human0.91683105
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91492365
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89688536
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89663360
138* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88436379
139* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88070359
140* UTX_26944678_Chip-Seq_JUKART_Human0.88014475
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87119713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.76697461
2MP0004957_abnormal_blastocyst_morpholog2.94942138
3MP0002877_abnormal_melanocyte_morpholog2.76045035
4MP0000013_abnormal_adipose_tissue2.56280276
5MP0002138_abnormal_hepatobiliary_system2.36740396
6MP0003724_increased_susceptibility_to2.36197746
7MP0003763_abnormal_thymus_physiology2.32187361
8MP0009333_abnormal_splenocyte_physiolog2.30526786
9MP0005671_abnormal_response_to2.14628749
10MP0009379_abnormal_foot_pigmentation2.12258605
11MP0006036_abnormal_mitochondrial_physio2.10768413
12MP0002693_abnormal_pancreas_physiology2.09368934
13MP0004043_abnormal_pH_regulation2.02984190
14MP0000678_abnormal_parathyroid_gland2.02756418
15MP0000685_abnormal_immune_system2.00254995
16MP0001944_abnormal_pancreas_morphology1.97765569
17MP0003866_abnormal_defecation1.90891332
18MP0003656_abnormal_erythrocyte_physiolo1.85493851
19MP0001501_abnormal_sleep_pattern1.85366523
20MP0002653_abnormal_ependyma_morphology1.82800789
21MP0003303_peritoneal_inflammation1.79481627
22MP0005084_abnormal_gallbladder_morpholo1.79045040
23MP0003300_gastrointestinal_ulcer1.77780234
24MP0002419_abnormal_innate_immunity1.76960438
25MP0002837_dystrophic_cardiac_calcinosis1.76309235
26MP0009840_abnormal_foam_cell1.73078607
27MP0003123_paternal_imprinting1.72660910
28MP0008007_abnormal_cellular_replicative1.71659017
29MP0004510_myositis1.69272321
30MP0005464_abnormal_platelet_physiology1.66593451
31MP0005220_abnormal_exocrine_pancreas1.61668543
32MP0003183_abnormal_peptide_metabolism1.60421382
33MP0008995_early_reproductive_senescence1.59712165
34MP0003806_abnormal_nucleotide_metabolis1.59577629
35MP0005000_abnormal_immune_tolerance1.58682160
36MP0001873_stomach_inflammation1.58428847
37MP0002909_abnormal_adrenal_gland1.58193928
38MP0003436_decreased_susceptibility_to1.56133781
39MP0001790_abnormal_immune_system1.53711258
40MP0005387_immune_system_phenotype1.53711258
41MP0003646_muscle_fatigue1.48591190
42MP0009764_decreased_sensitivity_to1.48356253
43MP0000490_abnormal_crypts_of1.47176953
44MP0008932_abnormal_embryonic_tissue1.46874373
45MP0003186_abnormal_redox_activity1.45944190
46MP0008004_abnormal_stomach_pH1.44514137
47MP0006054_spinal_hemorrhage1.42443830
48MP0009785_altered_susceptibility_to1.41287816
49MP0000750_abnormal_muscle_regeneration1.39023656
50MP0002132_abnormal_respiratory_system1.38999329
51MP0002277_abnormal_respiratory_mucosa1.37203371
52MP0005636_abnormal_mineral_homeostasis1.36102069
53MP0002148_abnormal_hypersensitivity_rea1.35906258
54MP0001542_abnormal_bone_strength1.35655417
55MP0000465_gastrointestinal_hemorrhage1.34987380
56MP0000858_altered_metastatic_potential1.34506867
57MP0001502_abnormal_circadian_rhythm1.33063680
58MP0005058_abnormal_lysosome_morphology1.26634017
59MP0005075_abnormal_melanosome_morpholog1.25834886
60MP0002163_abnormal_gland_morphology1.24936848
61MP0010386_abnormal_urinary_bladder1.24710816
62MP0010155_abnormal_intestine_physiology1.24388069
63MP0003077_abnormal_cell_cycle1.23895308
64MP0002933_joint_inflammation1.22812965
65MP0002723_abnormal_immune_serum1.22180465
66MP0002398_abnormal_bone_marrow1.22075275
67MP0005535_abnormal_body_temperature1.21620005
68MP0002405_respiratory_system_inflammati1.20268314
69MP0000372_irregular_coat_pigmentation1.19105038
70MP0004147_increased_porphyrin_level1.18898617
71MP0009278_abnormal_bone_marrow1.18855479
72MP0004947_skin_inflammation1.18361158
73MP0000003_abnormal_adipose_tissue1.18072650
74MP0002420_abnormal_adaptive_immunity1.16537441
75MP0002332_abnormal_exercise_endurance1.15353396
76MP0001819_abnormal_immune_cell1.14999237
77MP0005025_abnormal_response_to1.14864130
78MP0000613_abnormal_salivary_gland1.13436361
79MP0001800_abnormal_humoral_immune1.10325994
80MP0001853_heart_inflammation1.08943081
81MP0003195_calcinosis1.08523564
82MP0001545_abnormal_hematopoietic_system1.08249661
83MP0005397_hematopoietic_system_phenotyp1.08249661
84MP0002638_abnormal_pupillary_reflex1.08048604
85MP0002722_abnormal_immune_system1.07644610
86MP0000703_abnormal_thymus_morphology1.04936445
87MP0004142_abnormal_muscle_tone1.04797900
88MP0001845_abnormal_inflammatory_respons1.04776688
89MP0001905_abnormal_dopamine_level1.04768841
90MP0000343_altered_response_to1.04104569
91MP0001835_abnormal_antigen_presentation1.03015936
92MP0000716_abnormal_immune_system1.02711723
93MP0002452_abnormal_antigen_presenting1.02635543
94MP0000689_abnormal_spleen_morphology1.01944653
95MP0002429_abnormal_blood_cell1.01557949
96MP0005379_endocrine/exocrine_gland_phen1.01297814
97MP0000749_muscle_degeneration1.00890075
98MP0009643_abnormal_urine_homeostasis0.98280277
99MP0008872_abnormal_physiological_respon0.97959985
100MP0005410_abnormal_fertilization0.97054496
101MP0003880_abnormal_central_pattern0.96626590
102MP0002876_abnormal_thyroid_physiology0.95922498
103MP0003172_abnormal_lysosome_physiology0.95199110
104MP0005423_abnormal_somatic_nervous0.94841698
105MP0001533_abnormal_skeleton_physiology0.94042873
106MP0006276_abnormal_autonomic_nervous0.91577760
107MP0006035_abnormal_mitochondrial_morpho0.89326789
108MP0001764_abnormal_homeostasis0.88888730
109MP0005083_abnormal_biliary_tract0.88685972
110MP0008961_abnormal_basal_metabolism0.88433221
111MP0002078_abnormal_glucose_homeostasis0.88367814
112MP0008875_abnormal_xenobiotic_pharmacok0.86851083
113MP0002234_abnormal_pharynx_morphology0.86792930
114MP0001851_eye_inflammation0.86690533
115MP0002019_abnormal_tumor_incidence0.86298709
116MP0009763_increased_sensitivity_to0.86206233
117MP0006082_CNS_inflammation0.85922262
118MP0003786_premature_aging0.81756557
119MP0001756_abnormal_urination0.81287766
120MP0000350_abnormal_cell_proliferation0.81230755
121MP0001986_abnormal_taste_sensitivity0.80840833
122MP0004484_altered_response_of0.80783802
123MP0005076_abnormal_cell_differentiation0.80445396
124MP0001663_abnormal_digestive_system0.80344691
125MP0000313_abnormal_cell_death0.80326080
126MP0008469_abnormal_protein_level0.79989513
127MP0002822_catalepsy0.79701726
128MP0009745_abnormal_behavioral_response0.79558030
129MP0009765_abnormal_xenobiotic_induced0.78534458
130MP0005310_abnormal_salivary_gland0.77986270
131MP0003075_altered_response_to0.77934611
132MP0008260_abnormal_autophagy0.76641254
133MP0003828_pulmonary_edema0.76323510
134MP0004084_abnormal_cardiac_muscle0.75589706
135MP0005166_decreased_susceptibility_to0.75555274
136MP0005645_abnormal_hypothalamus_physiol0.75523955
137MP0003959_abnormal_lean_body0.75014529
138MP0008874_decreased_physiological_sensi0.74956879
139MP0001348_abnormal_lacrimal_gland0.74519836
140MP0000358_abnormal_cell_content/0.74484560
141MP0001765_abnormal_ion_homeostasis0.73876605
142MP0002272_abnormal_nervous_system0.72373653

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)4.32485775
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.32485775
3Abnormal mitochondria in muscle tissue (HP:0008316)4.27402964
4Acute necrotizing encephalopathy (HP:0006965)4.14898125
5Mitochondrial inheritance (HP:0001427)3.94325324
6Hepatic necrosis (HP:0002605)3.90550039
7Hepatocellular necrosis (HP:0001404)3.87634607
8Abnormality of cells of the erythroid lineage (HP:0012130)3.77983334
9Abnormal number of erythroid precursors (HP:0012131)3.69757814
10Acute encephalopathy (HP:0006846)3.45536847
11Increased CSF lactate (HP:0002490)3.34411570
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.32792671
133-Methylglutaconic aciduria (HP:0003535)3.19948342
14Progressive macrocephaly (HP:0004481)3.18870800
15Abnormal hemoglobin (HP:0011902)3.14128482
16Aplastic anemia (HP:0001915)3.05185882
17Trismus (HP:0000211)3.04008291
18Reticulocytopenia (HP:0001896)2.87870282
19Upper limb muscle weakness (HP:0003484)2.87677484
20IgG deficiency (HP:0004315)2.85294663
21Increased intramyocellular lipid droplets (HP:0012240)2.81764733
22Increased muscle lipid content (HP:0009058)2.71900444
23Respiratory failure (HP:0002878)2.66771562
24Exertional dyspnea (HP:0002875)2.66087159
25Abnormal gallbladder physiology (HP:0012438)2.62341812
26Cholecystitis (HP:0001082)2.62341812
27Oral leukoplakia (HP:0002745)2.62034777
28Lactic acidosis (HP:0003128)2.61845026
29Petechiae (HP:0000967)2.58740919
30Exercise intolerance (HP:0003546)2.58720463
31Abnormality of glycolipid metabolism (HP:0010969)2.57405167
32Abnormality of liposaccharide metabolism (HP:0010968)2.57405167
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.57405167
34Pallor (HP:0000980)2.57157275
35Hypercortisolism (HP:0001578)2.57142967
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57036069
37Macrocytic anemia (HP:0001972)2.55443194
38Increased serum lactate (HP:0002151)2.54968884
39Late onset (HP:0003584)2.54581227
40Renal Fanconi syndrome (HP:0001994)2.49600347
41Mutism (HP:0002300)2.46867968
42Increased IgM level (HP:0003496)2.38125920
43Myositis (HP:0100614)2.35208783
44Hypoglycemic coma (HP:0001325)2.35175500
45Microretrognathia (HP:0000308)2.35127320
46Muscle fiber atrophy (HP:0100295)2.33233800
47Neuroendocrine neoplasm (HP:0100634)2.31442305
48Degeneration of anterior horn cells (HP:0002398)2.30841394
49Abnormality of the anterior horn cell (HP:0006802)2.30841394
50Loss of speech (HP:0002371)2.29157440
51Increased hepatocellular lipid droplets (HP:0006565)2.27009143
52Palpitations (HP:0001962)2.25491834
53Progressive muscle weakness (HP:0003323)2.24787194
54Severe combined immunodeficiency (HP:0004430)2.21322847
55Multiple enchondromatosis (HP:0005701)2.20876907
56Progressive microcephaly (HP:0000253)2.20227705
57Lipid accumulation in hepatocytes (HP:0006561)2.18092989
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16089869
59Rough bone trabeculation (HP:0100670)2.14421538
60Prolonged bleeding time (HP:0003010)2.13903499
61Abnormality of calcium-phosphate metabolism (HP:0100530)2.13465241
62Gout (HP:0001997)2.13325408
63Joint swelling (HP:0001386)2.12918902
64Type I transferrin isoform profile (HP:0003642)2.12636264
65Unilateral renal agenesis (HP:0000122)2.12584411
66Symptomatic seizures (HP:0011145)2.11860761
67Pheochromocytoma (HP:0002666)2.10882890
68Respiratory difficulties (HP:0002880)2.10634712
69Hyperinsulinemic hypoglycemia (HP:0000825)2.08619031
70CNS demyelination (HP:0007305)2.08199864
71Neoplasm of head and neck (HP:0012288)2.07788874
72Esophageal neoplasm (HP:0100751)2.07788874
73Thrombocytosis (HP:0001894)2.07641723
74Oligomenorrhea (HP:0000876)2.07423033
75Papilledema (HP:0001085)2.07330271
76Optic neuritis (HP:0100653)2.06366720
77Retrobulbar optic neuritis (HP:0100654)2.06366720
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.03251912
79Vasculitis (HP:0002633)2.03166606
80Ventricular fibrillation (HP:0001663)2.02367677
81Myopathic facies (HP:0002058)2.01762170
82Abnormality of T cell physiology (HP:0011840)2.01362387
83Increased serum ferritin (HP:0003281)2.01206907
84Parakeratosis (HP:0001036)2.00976765
8511 pairs of ribs (HP:0000878)2.00241513
86Vacuolated lymphocytes (HP:0001922)1.99781093
87Granulocytopenia (HP:0001913)1.99005693
88Abnormality of macrophages (HP:0004311)1.98441317
89Metaphyseal dysplasia (HP:0100255)1.97902725
90Delusions (HP:0000746)1.97022044
91Abnormality of eosinophils (HP:0001879)1.96331099
92Abnormal protein glycosylation (HP:0012346)1.96005449
93Abnormal glycosylation (HP:0012345)1.96005449
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96005449
95Abnormal protein N-linked glycosylation (HP:0012347)1.96005449
96Pulmonary fibrosis (HP:0002206)1.95787402
97Cerebral hypomyelination (HP:0006808)1.95128007
98Episodic fever (HP:0001954)1.94676721
99Fatigue (HP:0012378)1.93862316
100Growth hormone excess (HP:0000845)1.93690910
101Emotional lability (HP:0000712)1.93645924
102Tongue fasciculations (HP:0001308)1.93521485
103Mediastinal lymphadenopathy (HP:0100721)1.93100654
104Stomatitis (HP:0010280)1.91436806
105Abnormality of T cells (HP:0002843)1.90516421
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90273289
107Abnormality of alanine metabolism (HP:0010916)1.90273289
108Hyperalaninemia (HP:0003348)1.90273289
109Dysostosis multiplex (HP:0000943)1.90053372
110Hyperparathyroidism (HP:0000843)1.89678304
111Ragged-red muscle fibers (HP:0003200)1.89566804
112Panhypogammaglobulinemia (HP:0003139)1.88655009
113Poor suck (HP:0002033)1.87982226
114Pulmonary infiltrates (HP:0002113)1.87981482
115Optic disc pallor (HP:0000543)1.87846195
116Medial flaring of the eyebrow (HP:0010747)1.87315625
117Stomach cancer (HP:0012126)1.87299308
118Abnormality of the prostate (HP:0008775)1.86537175
119Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86412804
120Hypoglycemic seizures (HP:0002173)1.86393343
121Neutropenia (HP:0001875)1.85648271
122Abnormality of iron homeostasis (HP:0011031)1.85621514
123Pustule (HP:0200039)1.85286866
124Secondary amenorrhea (HP:0000869)1.85256303
125Generalized aminoaciduria (HP:0002909)1.84688538
126Elevated erythrocyte sedimentation rate (HP:0003565)1.83109108
127Purpura (HP:0000979)1.82492458
128Aplasia/hypoplasia of the uterus (HP:0008684)1.80380020
129Eosinophilia (HP:0001880)1.80078407
130Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78719490
131Insulin resistance (HP:0000855)1.78691092
132Nasal polyposis (HP:0100582)1.78533957
133Rhabdomyolysis (HP:0003201)1.77648044
134Chronic obstructive pulmonary disease (HP:0006510)1.77602342
135Obstructive lung disease (HP:0006536)1.77602342
136Progressive neurologic deterioration (HP:0002344)1.76731601
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.76385571
138Abnormality of transition element cation homeostasis (HP:0011030)1.76362771
139Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75726829
140Febrile seizures (HP:0002373)1.75671994
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75257047
142Dicarboxylic aciduria (HP:0003215)1.75257047
143Irregular epiphyses (HP:0010582)1.75094503
144Polycythemia (HP:0001901)1.74916337
145Sparse eyelashes (HP:0000653)1.74853111
146Abnormality of dental color (HP:0011073)1.74818574
147Conjunctival hamartoma (HP:0100780)1.74716747
148Large for gestational age (HP:0001520)1.74528445
149Orchitis (HP:0100796)1.74391282
150Menstrual irregularities (HP:0000858)1.74193184
151Type 2 muscle fiber atrophy (HP:0003554)1.73631328
152Abnormality of the nasal mucosa (HP:0000433)1.72995780
153Hypergammaglobulinemia (HP:0010702)1.72843480
154Polyphagia (HP:0002591)1.72391992
155Carpal bone hypoplasia (HP:0001498)1.72111194
156Cerebral edema (HP:0002181)1.71824244
157Vertebral compression fractures (HP:0002953)1.71631033
158Insulin-resistant diabetes mellitus (HP:0000831)1.70513013
159Interstitial pulmonary disease (HP:0006530)1.70194592
160Autoimmune hemolytic anemia (HP:0001890)1.70074621
161Alveolar cell carcinoma (HP:0006519)1.69011339
162Supranuclear gaze palsy (HP:0000605)1.68854974
163Leukocytosis (HP:0001974)1.68518322
164Peripheral hypomyelination (HP:0007182)1.68391232
165Abnormal pupillary function (HP:0007686)1.68389499
166Shoulder girdle muscle weakness (HP:0003547)1.67161410
167Eczematoid dermatitis (HP:0000976)1.65990282
168Abnormal pancreas size (HP:0012094)1.65575143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.50779755
2EIF2AK12.95662429
3TESK22.87053941
4MAPK152.80793665
5PIM22.75274611
6BUB12.55242904
7MST42.43957343
8TESK12.31195330
9ERN12.15078965
10TSSK62.12540360
11TRIB32.12242903
12NME12.06256091
13BMPR22.03904584
14GRK62.00793659
15IRAK31.99805098
16TRIM281.94320512
17PASK1.92920149
18RIPK41.91643941
19MAP3K111.87500294
20RPS6KA41.86320599
21MAP4K21.85706056
22CDK191.80417953
23STK161.76833476
24NLK1.74526935
25VRK11.68687676
26LIMK11.67866659
27MAP4K11.66824126
28ZAP701.61890265
29MAP3K121.57335955
30TBK11.56589759
31MAP3K51.54836796
32TXK1.54106849
33IRAK11.53997455
34SIK31.52600810
35TLK11.52260257
36FES1.48971994
37TAOK21.46319275
38CCNB11.44914319
39KDR1.44422334
40MAPKAPK31.40402606
41PINK11.36446758
42PRPF4B1.33945060
43MAP2K21.25306221
44MAP3K31.23107909
45BRAF1.21987672
46BRSK21.20577039
47CDK81.19624849
48DYRK31.17549462
49HIPK21.16325963
50SYK1.14148034
51BCKDK1.10547908
52NEK11.10224943
53LRRK21.08923297
54WEE11.07960193
55SIK21.07665668
56MATK1.06739131
57GRK71.05350732
58EIF2AK31.02069524
59TNK20.97435592
60ACVR1B0.96770360
61MAP3K10.94957952
62MOS0.94950223
63EPHA30.94885404
64ERBB30.94563783
65TAOK10.93995087
66JAK30.93038479
67PIK3CG0.92526923
68ADRBK20.90996278
69ARAF0.87110392
70IKBKE0.86559246
71TEC0.84739561
72LYN0.84282379
73BLK0.81209456
74DAPK20.79772404
75FGFR40.79083449
76NEK90.78805897
77PHKG20.78740306
78PHKG10.78740306
79IKBKB0.78212447
80GRK50.78082969
81KIT0.77927723
82TAOK30.75688401
83PBK0.74974773
84MAPK70.73792029
85DYRK20.73492730
86AURKA0.72928358
87EPHB10.71532781
88HCK0.69963948
89DYRK1B0.69797085
90BRSK10.69604815
91EPHA20.68769441
92WNK40.67094689
93PRKCI0.66857374
94MARK30.66490573
95ILK0.66248558
96MKNK20.65938171
97CHUK0.64725685
98MAP2K60.64425146
99MAPK120.64255891
100PAK60.63324292
101PRKG20.62262104
102MAP3K130.61962352
103PAK40.61241421
104JAK10.60610897
105ITK0.60597182
106PRKCQ0.59199496
107STK240.56531234
108MAP3K140.56504853
109MAP2K30.55404399
110MAPKAPK20.52462764
111STK100.51039866
112IRAK40.50413618
113PDK20.49656624
114AURKB0.49242990
115CSF1R0.48379358
116JAK20.47574680
117TGFBR10.46645523
118MAPK40.45057165
119PLK10.45048468
120PTK2B0.44719570
121TYK20.43178519
122UHMK10.41437995
123ABL20.40668856
124SCYL20.40298317
125DAPK30.39517445
126PIM10.39476261
127RPS6KA50.39439478
128PAK30.39359745
129GRK10.39154733
130MUSK0.38978269
131PKN10.38947159
132BMPR1B0.38892162
133FLT30.38133025
134ABL10.36028821
135NEK20.34634392
136CSNK1G30.34571998
137PRKD10.33123295
138MYLK0.33101030
139BCR0.32202583
140CSNK2A10.32073040
141PAK10.31867872
142BTK0.31867723
143DAPK10.30425974
144CASK0.28862124
145LCK0.28602908

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.74828356
2Protein export_Homo sapiens_hsa030604.23831407
3Proteasome_Homo sapiens_hsa030503.39787435
4Oxidative phosphorylation_Homo sapiens_hsa001903.39168009
5Maturity onset diabetes of the young_Homo sapiens_hsa049503.20642507
6Parkinsons disease_Homo sapiens_hsa050123.09537197
7RNA polymerase_Homo sapiens_hsa030202.91592305
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49670056
9Graft-versus-host disease_Homo sapiens_hsa053322.40172375
10Spliceosome_Homo sapiens_hsa030402.32686149
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17968432
12Huntingtons disease_Homo sapiens_hsa050162.16936513
13Vibrio cholerae infection_Homo sapiens_hsa051101.94836725
14Alzheimers disease_Homo sapiens_hsa050101.91456430
15Pyrimidine metabolism_Homo sapiens_hsa002401.87243227
16Folate biosynthesis_Homo sapiens_hsa007901.80664507
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74713891
18DNA replication_Homo sapiens_hsa030301.69427514
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64606984
20Legionellosis_Homo sapiens_hsa051341.61348406
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60456812
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60268460
23Collecting duct acid secretion_Homo sapiens_hsa049661.44371543
24Antigen processing and presentation_Homo sapiens_hsa046121.41489675
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40096573
26Mismatch repair_Homo sapiens_hsa034301.30575418
27* RNA transport_Homo sapiens_hsa030131.30411614
28Type I diabetes mellitus_Homo sapiens_hsa049401.29464559
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29280132
30Sulfur relay system_Homo sapiens_hsa041221.22288836
31Regulation of autophagy_Homo sapiens_hsa041401.20183476
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17771643
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16894051
34Homologous recombination_Homo sapiens_hsa034401.16695082
35Fatty acid elongation_Homo sapiens_hsa000621.16532115
36Primary immunodeficiency_Homo sapiens_hsa053401.16287020
37Epstein-Barr virus infection_Homo sapiens_hsa051691.15456065
38Nucleotide excision repair_Homo sapiens_hsa034201.12690395
39Base excision repair_Homo sapiens_hsa034101.10514610
40p53 signaling pathway_Homo sapiens_hsa041151.07375683
41Rheumatoid arthritis_Homo sapiens_hsa053231.07155274
42Basal transcription factors_Homo sapiens_hsa030221.04800429
43Viral myocarditis_Homo sapiens_hsa054161.02673716
44Phototransduction_Homo sapiens_hsa047441.01889485
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99162241
46RNA degradation_Homo sapiens_hsa030180.98940213
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.96717807
48Shigellosis_Homo sapiens_hsa051310.94914166
49Cell cycle_Homo sapiens_hsa041100.93850028
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93567338
51Purine metabolism_Homo sapiens_hsa002300.91213362
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88169475
53Pentose phosphate pathway_Homo sapiens_hsa000300.87165512
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.86791211
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80011361
56Salmonella infection_Homo sapiens_hsa051320.78305342
57Herpes simplex infection_Homo sapiens_hsa051680.78214469
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78121481
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76025663
60Malaria_Homo sapiens_hsa051440.74763865
61Hematopoietic cell lineage_Homo sapiens_hsa046400.74180877
62Cardiac muscle contraction_Homo sapiens_hsa042600.73357935
63B cell receptor signaling pathway_Homo sapiens_hsa046620.72616580
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72101684
65Measles_Homo sapiens_hsa051620.68795569
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68327240
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.66929765
68Leishmaniasis_Homo sapiens_hsa051400.66129176
69Thyroid cancer_Homo sapiens_hsa052160.66099470
70Staphylococcus aureus infection_Homo sapiens_hsa051500.65837687
71Acute myeloid leukemia_Homo sapiens_hsa052210.64660321
72Carbon metabolism_Homo sapiens_hsa012000.64514578
73N-Glycan biosynthesis_Homo sapiens_hsa005100.64370889
74Chemokine signaling pathway_Homo sapiens_hsa040620.64076942
75Lysosome_Homo sapiens_hsa041420.61514607
76Bladder cancer_Homo sapiens_hsa052190.61183704
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.61160940
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59948355
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58756414
80Other glycan degradation_Homo sapiens_hsa005110.58342644
81Allograft rejection_Homo sapiens_hsa053300.57972622
82Prolactin signaling pathway_Homo sapiens_hsa049170.57664810
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57590722
84T cell receptor signaling pathway_Homo sapiens_hsa046600.57079148
85Galactose metabolism_Homo sapiens_hsa000520.56707650
86Sulfur metabolism_Homo sapiens_hsa009200.55591575
87GABAergic synapse_Homo sapiens_hsa047270.54831711
88Fructose and mannose metabolism_Homo sapiens_hsa000510.54654094
89Apoptosis_Homo sapiens_hsa042100.54012822
90Hepatitis B_Homo sapiens_hsa051610.53876852
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51249093
92Endocytosis_Homo sapiens_hsa041440.50144776
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.49984743
94Circadian rhythm_Homo sapiens_hsa047100.49798578
95Morphine addiction_Homo sapiens_hsa050320.49465992
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47777099
97TNF signaling pathway_Homo sapiens_hsa046680.46403162
98HTLV-I infection_Homo sapiens_hsa051660.44955671
99Influenza A_Homo sapiens_hsa051640.43259038
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43164373
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42556083
102Pertussis_Homo sapiens_hsa051330.41925583
103Amphetamine addiction_Homo sapiens_hsa050310.41791357
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41772037
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41114354
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40003862
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39127495
108Arachidonic acid metabolism_Homo sapiens_hsa005900.38849071
109African trypanosomiasis_Homo sapiens_hsa051430.38207263
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37264517
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37148795
112Biosynthesis of amino acids_Homo sapiens_hsa012300.34829778
113Osteoclast differentiation_Homo sapiens_hsa043800.33258135
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33163476
115Phagosome_Homo sapiens_hsa041450.32960224
116MAPK signaling pathway_Homo sapiens_hsa040100.32769233
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32235355
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.31288061
119HIF-1 signaling pathway_Homo sapiens_hsa040660.31230869
120Tuberculosis_Homo sapiens_hsa051520.31046157
121Asthma_Homo sapiens_hsa053100.30984358
122Autoimmune thyroid disease_Homo sapiens_hsa053200.30564003
123Pyruvate metabolism_Homo sapiens_hsa006200.29356257
124Toxoplasmosis_Homo sapiens_hsa051450.28917755
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28150612
126Synaptic vesicle cycle_Homo sapiens_hsa047210.27893942
127Metabolic pathways_Homo sapiens_hsa011000.27851572
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27785857
129Olfactory transduction_Homo sapiens_hsa047400.27635932
130Nitrogen metabolism_Homo sapiens_hsa009100.26691789
131Selenocompound metabolism_Homo sapiens_hsa004500.26588302
132One carbon pool by folate_Homo sapiens_hsa006700.26154725
133Insulin secretion_Homo sapiens_hsa049110.24596338
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23780932
135Peroxisome_Homo sapiens_hsa041460.22470419
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21215790
137Sphingolipid metabolism_Homo sapiens_hsa006000.21108156
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17704678

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