EID3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.93065987
2binding of sperm to zona pellucida (GO:0007339)9.89306296
3motile cilium assembly (GO:0044458)9.43157569
4reproduction (GO:0000003)9.29687824
5epithelial cilium movement (GO:0003351)9.29322634
6piRNA metabolic process (GO:0034587)9.23765906
7spermatid development (GO:0007286)9.00865382
8male meiosis (GO:0007140)8.62094009
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.92735934
10cilium movement (GO:0003341)7.83864655
11synaptonemal complex organization (GO:0070193)7.76842084
12synaptonemal complex assembly (GO:0007130)7.46175648
13single fertilization (GO:0007338)7.24083978
14regulation of cilium movement (GO:0003352)7.06154920
15sperm capacitation (GO:0048240)6.29475935
16fertilization (GO:0009566)6.20341619
17negative regulation of inclusion body assembly (GO:0090084)6.05559074
18DNA methylation involved in gamete generation (GO:0043046)5.98311945
19reciprocal DNA recombination (GO:0035825)5.89959257
20reciprocal meiotic recombination (GO:0007131)5.89959257
21spermatogenesis (GO:0007283)5.87813016
22male gamete generation (GO:0048232)5.85683134
23male meiosis I (GO:0007141)5.59947438
24microtubule depolymerization (GO:0007019)5.48854984
25gamete generation (GO:0007276)5.38929758
26chromosome organization involved in meiosis (GO:0070192)5.30823858
27organic cation transport (GO:0015695)5.29415578
28sister chromatid cohesion (GO:0007062)5.21215282
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.18725912
30ventricular system development (GO:0021591)5.14268497
31germ cell development (GO:0007281)5.13278609
32meiotic nuclear division (GO:0007126)4.98081778
33seminiferous tubule development (GO:0072520)4.81497651
34negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.77715346
35regulation of inclusion body assembly (GO:0090083)4.69005511
36pyrimidine nucleoside salvage (GO:0043097)4.66448925
37pyrimidine-containing compound salvage (GO:0008655)4.66448925
38cell recognition (GO:0008037)4.61707599
39meiosis I (GO:0007127)4.45340926
40calcium ion-dependent exocytosis (GO:0017156)4.43709739
41histone H3-K9 demethylation (GO:0033169)4.35571967
42keratinocyte development (GO:0003334)4.32732105
43spermatid nucleus differentiation (GO:0007289)4.25870484
44monoubiquitinated protein deubiquitination (GO:0035520)4.23462461
45multicellular organismal reproductive process (GO:0048609)4.20699862
46meiotic cell cycle (GO:0051321)4.11664062
47regulation of retinoic acid receptor signaling pathway (GO:0048385)4.07390102
48diterpenoid biosynthetic process (GO:0016102)4.05200984
49regulation of microtubule-based movement (GO:0060632)4.00822948
50female gamete generation (GO:0007292)3.96468148
51nucleoside salvage (GO:0043174)3.90047955
52microtubule severing (GO:0051013)3.89695984
53protein localization to cilium (GO:0061512)3.88366215
54DNA alkylation (GO:0006305)3.87477814
55DNA methylation (GO:0006306)3.87477814
56nucleotide salvage (GO:0043173)3.78196538
57pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.73169672
58UMP biosynthetic process (GO:0006222)3.73169672
59pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.73169672
60UMP metabolic process (GO:0046049)3.73169672
61left/right pattern formation (GO:0060972)3.70452238
62genitalia morphogenesis (GO:0035112)3.63850832
63attachment of spindle microtubules to kinetochore (GO:0008608)3.61536980
64positive regulation of meiosis (GO:0045836)3.61328451
65regulation of DNA endoreduplication (GO:0032875)3.57835021
66glycerol ether metabolic process (GO:0006662)3.57334500
67gene silencing by RNA (GO:0031047)3.51162649
68nuclear pore complex assembly (GO:0051292)3.49955121
69chaperone-mediated protein complex assembly (GO:0051131)3.47203686
70positive regulation of meiotic cell cycle (GO:0051446)3.44975724
71chromosome condensation (GO:0030261)3.42883807
72retinal cone cell development (GO:0046549)3.39688841
73multicellular organismal development (GO:0007275)3.38844242
74regulation of meiotic cell cycle (GO:0051445)3.36449315
75DNA packaging (GO:0006323)3.32948427
76pericardium development (GO:0060039)3.31390802
77protein K11-linked deubiquitination (GO:0035871)3.28357638
78ether metabolic process (GO:0018904)3.27661123
79regulation of centriole replication (GO:0046599)3.26440685
80protein localization to chromosome (GO:0034502)3.25717282
81synapsis (GO:0007129)3.24858183
82centriole assembly (GO:0098534)3.24406675
83histone H3-K36 demethylation (GO:0070544)3.21891821
84regulation of protein polyubiquitination (GO:1902914)3.18825849
85regulation of spindle checkpoint (GO:0090231)3.16898890
86centriole replication (GO:0007099)3.13801220
87lactate metabolic process (GO:0006089)3.12836881
88meiotic cell cycle process (GO:1903046)3.08473051
89negative regulation of DNA repair (GO:0045738)3.07954034
90resolution of meiotic recombination intermediates (GO:0000712)3.07906853
91interferon-gamma secretion (GO:0072643)3.07568787
92meiotic chromosome segregation (GO:0045132)3.07415083
93intraciliary transport (GO:0042073)3.06633437
94mitotic sister chromatid cohesion (GO:0007064)3.05847713
95DNA methylation or demethylation (GO:0044728)3.01762993
96carnitine transport (GO:0015879)3.00855577
97amino-acid betaine transport (GO:0015838)3.00855577
98axoneme assembly (GO:0035082)2.99976449
99carnitine transmembrane transport (GO:1902603)2.97583522
100negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.95440496
101pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.94285212
102protein polyglutamylation (GO:0018095)2.94181092
103regulation of interleukin-12 biosynthetic process (GO:0045075)2.94000982
104microtubule-based movement (GO:0007018)2.91104128
105DNA biosynthetic process (GO:0071897)2.89719413
106microtubule anchoring (GO:0034453)2.85978511
107cilium organization (GO:0044782)2.85641520
108peptidyl-lysine dimethylation (GO:0018027)2.85416657
109natural killer cell mediated cytotoxicity (GO:0042267)2.83970698
110natural killer cell mediated immunity (GO:0002228)2.83970698
111peptidyl-lysine trimethylation (GO:0018023)2.83926793
112histone H4-K16 acetylation (GO:0043984)2.83627029
113single strand break repair (GO:0000012)2.81683787
114pore complex assembly (GO:0046931)2.81610981
115polyol catabolic process (GO:0046174)2.80558342
116reproductive system development (GO:0061458)2.79717318
117interleukin-6-mediated signaling pathway (GO:0070102)2.75719348
118regulation of podosome assembly (GO:0071801)2.72349902
119nucleus organization (GO:0006997)2.72263273
120cellular component assembly involved in morphogenesis (GO:0010927)2.70527029
121cilium assembly (GO:0042384)2.70473819
122negative regulation of organelle assembly (GO:1902116)2.70161399
123pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.69388368
124neutrophil mediated immunity (GO:0002446)2.68224005
125microtubule polymerization or depolymerization (GO:0031109)2.68156924
126sexual reproduction (GO:0019953)2.67877220
127nuclear pore organization (GO:0006999)2.66652784
128protein refolding (GO:0042026)2.65698114
129histone H2A acetylation (GO:0043968)2.64718817
130regulation of activation of Janus kinase activity (GO:0010533)2.63495655
131activation of NF-kappaB-inducing kinase activity (GO:0007250)2.62312505
132regulation of meiosis I (GO:0060631)2.61123207
133gene silencing (GO:0016458)2.61117468
134alditol metabolic process (GO:0019400)2.60008161
135interkinetic nuclear migration (GO:0022027)2.59293750
136regulation of female receptivity (GO:0045924)2.59250369
137protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.59009257
138cilium morphogenesis (GO:0060271)2.57813522
139negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.57806480
140chromosome organization (GO:0051276)2.56680727
141sequestering of actin monomers (GO:0042989)2.56407395
142DNA modification (GO:0006304)2.54163903
143negative regulation of type I interferon production (GO:0032480)2.52650071
144negative regulation of JAK-STAT cascade (GO:0046426)2.52154946
145growth hormone receptor signaling pathway (GO:0060396)2.50012897
146regulation of histone H3-K9 methylation (GO:0051570)2.48749726
147regulation of meiosis (GO:0040020)2.48596855
148protein K6-linked ubiquitination (GO:0085020)2.40325831
149positive regulation of interleukin-17 production (GO:0032740)2.39506296
150centrosome duplication (GO:0051298)2.38353363
151retinal metabolic process (GO:0042574)2.35863843
152embryonic skeletal system development (GO:0048706)2.34903597
153histone H4-K8 acetylation (GO:0043982)2.33892232
154histone H4-K5 acetylation (GO:0043981)2.33892232
155negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.33615390
156negative regulation of T-helper cell differentiation (GO:0045623)2.33615390
157oogenesis (GO:0048477)2.32145453
158histone H3-K9 methylation (GO:0051567)2.31388398
159fusion of sperm to egg plasma membrane (GO:0007342)13.7529012
160cilium or flagellum-dependent cell motility (GO:0001539)12.9971514
161sperm motility (GO:0030317)12.0040921
162cell wall macromolecule catabolic process (GO:0016998)11.9441408
163cell wall macromolecule metabolic process (GO:0044036)11.9441408
164acrosome assembly (GO:0001675)11.5814359
165multicellular organism reproduction (GO:0032504)11.1877656
166sperm-egg recognition (GO:0035036)11.0118520
167DNA synthesis involved in DNA repair (GO:0000731)10.8666157
168plasma membrane fusion (GO:0045026)10.3779099
169axonemal dynein complex assembly (GO:0070286)10.2957536
170acrosome reaction (GO:0007340)10.2137892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.58198886
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.23600050
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.15380389
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.95176521
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.61995378
6EZH2_22144423_ChIP-Seq_EOC_Human3.56986757
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.38622862
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79276660
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.56504922
10RNF2_27304074_Chip-Seq_NSC_Mouse2.50376144
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.48315333
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.37248763
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23770939
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21843872
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20386041
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15238104
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12182402
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.07536270
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02455095
20RUNX_20019798_ChIP-Seq_JUKART_Human2.01254052
21TAF15_26573619_Chip-Seq_HEK293_Human2.00307835
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.8403302
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99886590
24ZNF274_21170338_ChIP-Seq_K562_Hela1.93690683
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91944763
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90981029
27IGF1R_20145208_ChIP-Seq_DFB_Human1.89080413
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87092919
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.85632077
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.85632077
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.85632077
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82755948
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.82003273
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73494674
35BCAT_22108803_ChIP-Seq_LS180_Human1.73064738
36* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70533156
37FUS_26573619_Chip-Seq_HEK293_Human1.69667461
38VDR_22108803_ChIP-Seq_LS180_Human1.69141294
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.64397602
40STAT1_17558387_ChIP-Seq_HELA_Human1.60935321
41TP53_22573176_ChIP-Seq_HFKS_Human1.60405094
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59302742
43* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56268947
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.54498078
45P300_19829295_ChIP-Seq_ESCs_Human1.53127368
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51740561
47ELK1_19687146_ChIP-ChIP_HELA_Human1.49106211
48* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49082764
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.48423145
50GATA3_26560356_Chip-Seq_TH2_Human1.46258892
51FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45750632
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45039027
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44805326
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44198829
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43769898
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.42596015
57KDM2B_26808549_Chip-Seq_REH_Human1.42335362
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.41554369
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40064757
60EWS_26573619_Chip-Seq_HEK293_Human1.39791715
61* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39179032
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38809605
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38369332
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37237350
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36622546
66VDR_23849224_ChIP-Seq_CD4+_Human1.35150185
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34168193
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34075476
69CBP_20019798_ChIP-Seq_JUKART_Human1.34075476
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33068121
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32396027
72WDR5_24793694_ChIP-Seq_LNCAP_Human1.31729109
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.31681952
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31625775
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29978263
76TCF4_23295773_ChIP-Seq_U87_Human1.28939496
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27147140
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.27005860
79STAT3_23295773_ChIP-Seq_U87_Human1.22388847
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.22071639
81SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21904957
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.21026244
83GATA3_21867929_ChIP-Seq_CD8_Mouse1.20747682
84* FLI1_21867929_ChIP-Seq_TH2_Mouse1.20639830
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.20171545
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19841430
87* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19185511
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18728050
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.17848227
90AR_25329375_ChIP-Seq_VCAP_Human1.17741763
91* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17648691
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16829274
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16810540
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15647908
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15541995
96P53_22387025_ChIP-Seq_ESCs_Mouse1.15451980
97EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14666719
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13350193
99AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13285084
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.12910894
101GF1_26923725_Chip-Seq_HPCs_Mouse1.11938831
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11420476
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11344424
104GATA3_21867929_ChIP-Seq_TH1_Mouse1.11227349
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.10738933
106RUNX2_22187159_ChIP-Seq_PCA_Human1.10049454
107TCF4_22108803_ChIP-Seq_LS180_Human1.09755723
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09751422
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09751422
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.09479604
111P300_18555785_Chip-Seq_ESCs_Mouse1.09243108
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08969686
113GATA3_26560356_Chip-Seq_TH1_Human1.08427464
114* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08064901
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.07029615
116SMAD4_21799915_ChIP-Seq_A2780_Human1.07012110
117MYC_18940864_ChIP-ChIP_HL60_Human1.05881237
118ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05477542
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05185222
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04671003
121RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04609024
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04606102
123ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04447262
124TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04422539
125STAT3_18555785_Chip-Seq_ESCs_Mouse1.04295667
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04052616
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03615430
128PU1_27457419_Chip-Seq_LIVER_Mouse1.03498552
129FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03269006
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02939945
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02620264
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02137164
133SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02111744
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02042253
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01405118
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00548072
137IRF1_19129219_ChIP-ChIP_H3396_Human0.99286529
138* SMAD4_21741376_ChIP-Seq_EPCs_Human0.99270729
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99177654
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98799183
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98778518
142* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98123817
143P53_21459846_ChIP-Seq_SAOS-2_Human0.98111476
144MYB_26560356_Chip-Seq_TH2_Human0.97202184
145CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95713748
146HOXB7_26014856_ChIP-Seq_BT474_Human0.94580932
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94160246
148* BRD4_25478319_ChIP-Seq_HGPS_Human0.94136978
149TP63_19390658_ChIP-ChIP_HaCaT_Human0.93662556
150SOX2_18555785_Chip-Seq_ESCs_Mouse0.93351098
151ESET_19884257_ChIP-Seq_ESCs_Mouse0.93098571
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92560124
153NANOG_19829295_ChIP-Seq_ESCs_Human0.91122428
154SOX2_19829295_ChIP-Seq_ESCs_Human0.91122428
155E2F1_18555785_Chip-Seq_ESCs_Mouse0.90999182
156ETV1_20927104_ChIP-Seq_GIST48_Human0.90883721
157GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90720595
158RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90656763
159CTCF_18555785_Chip-Seq_ESCs_Mouse0.90246604
160VDR_24787735_ChIP-Seq_THP-1_Human0.90227505
161SPI1_26923725_Chip-Seq_HPCs_Mouse0.90093186
162TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89645742
163IRF8_22096565_ChIP-ChIP_GC-B_Human0.89559626
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88914736
165SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88039575
166SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86669634
167ZFX_18555785_Chip-Seq_ESCs_Mouse0.85641373
168NFYB_21822215_ChIP-Seq_K562_Human0.85527545
169GF1B_26923725_Chip-Seq_HPCs_Mouse0.85416758
170EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84296211
171ER_23166858_ChIP-Seq_MCF-7_Human0.84038459
172SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83585959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.63248002
2MP0001929_abnormal_gametogenesis5.25610768
3MP0008877_abnormal_DNA_methylation4.91019773
4MP0000383_abnormal_hair_follicle3.64350194
5MP0002210_abnormal_sex_determination3.56737722
6MP0000569_abnormal_digit_pigmentation3.22746554
7MP0002161_abnormal_fertility/fecundity3.00740809
8MP0001145_abnormal_male_reproductive2.96869054
9MP0010678_abnormal_skin_adnexa2.79835756
10MP0000653_abnormal_sex_gland2.54151925
11MP0001986_abnormal_taste_sensitivity2.42079733
12MP0002653_abnormal_ependyma_morphology2.34043901
13MP0005310_abnormal_salivary_gland2.29746913
14MP0002138_abnormal_hepatobiliary_system2.24766467
15MP0002095_abnormal_skin_pigmentation2.12040243
16MP0008057_abnormal_DNA_replication2.07589696
17MP0005410_abnormal_fertilization14.7493840
18MP0003718_maternal_effect1.97141105
19MP0001661_extended_life_span1.87766251
20MP0009278_abnormal_bone_marrow1.79880820
21MP0002160_abnormal_reproductive_system1.62904363
22MP0002139_abnormal_hepatobiliary_system1.62770607
23MP0001873_stomach_inflammation1.52815367
24MP0005670_abnormal_white_adipose1.51199042
25MP0010386_abnormal_urinary_bladder1.49209199
26MP0003763_abnormal_thymus_physiology1.44214356
27MP0001545_abnormal_hematopoietic_system1.36492060
28MP0005397_hematopoietic_system_phenotyp1.36492060
29MP0005623_abnormal_meninges_morphology1.33236560
30MP0008058_abnormal_DNA_repair1.30826756
31MP0003646_muscle_fatigue1.25902763
32MP0000647_abnormal_sebaceous_gland1.25897841
33MP0003693_abnormal_embryo_hatching1.24507385
34MP0001348_abnormal_lacrimal_gland1.21138657
35MP0005174_abnormal_tail_pigmentation1.20993961
36MP0001501_abnormal_sleep_pattern1.17202684
37MP0005647_abnormal_sex_gland1.14471942
38MP0002102_abnormal_ear_morphology1.11666113
39MP0010307_abnormal_tumor_latency1.11044275
40MP0005084_abnormal_gallbladder_morpholo1.10222811
41MP0004808_abnormal_hematopoietic_stem1.09845803
42MP0008004_abnormal_stomach_pH1.08588181
43MP0003724_increased_susceptibility_to1.08207659
44MP0010094_abnormal_chromosome_stability1.07831479
45MP0002282_abnormal_trachea_morphology1.06773103
46MP0002163_abnormal_gland_morphology1.04233706
47MP0001835_abnormal_antigen_presentation1.03640025
48MP0001502_abnormal_circadian_rhythm1.01968150
49MP0001243_abnormal_dermal_layer1.00729720
50MP0002876_abnormal_thyroid_physiology0.97347768
51MP0005646_abnormal_pituitary_gland0.91813083
52MP0006292_abnormal_olfactory_placode0.90182717
53MP0006082_CNS_inflammation0.89921508
54MP0008007_abnormal_cellular_replicative0.89127863
55MP0000015_abnormal_ear_pigmentation0.87667755
56MP0003195_calcinosis0.86702069
57MP0005395_other_phenotype0.85769119
58MP0001765_abnormal_ion_homeostasis0.84539398
59MP0004233_abnormal_muscle_weight0.83807920
60MP0009046_muscle_twitch0.82759341
61MP0005389_reproductive_system_phenotype0.82721770
62MP0005076_abnormal_cell_differentiation0.82468729
63MP0004947_skin_inflammation0.80498471
64MP0002928_abnormal_bile_duct0.80456004
65MP0009785_altered_susceptibility_to0.80248299
66MP0002405_respiratory_system_inflammati0.79650088
67MP0008995_early_reproductive_senescence0.78481309
68MP0001346_abnormal_lacrimal_gland0.75910281
69MP0005379_endocrine/exocrine_gland_phen0.75596400
70MP0002722_abnormal_immune_system0.74052241
71MP0002419_abnormal_innate_immunity0.74012942
72MP0005187_abnormal_penis_morphology0.73812766
73MP0003252_abnormal_bile_duct0.73501248
74MP0003786_premature_aging0.73019820
75MP0003436_decreased_susceptibility_to0.71761776
76MP0005503_abnormal_tendon_morphology0.70630619
77MP0001984_abnormal_olfaction0.70252825
78MP0000372_irregular_coat_pigmentation0.68704914
79MP0005025_abnormal_response_to0.66541623
80MP0000538_abnormal_urinary_bladder0.66281547
81MP0002277_abnormal_respiratory_mucosa0.64667255
82MP0002723_abnormal_immune_serum0.64261804
83MP0002693_abnormal_pancreas_physiology0.64190108
84MP0003123_paternal_imprinting0.63859532
85MP0003183_abnormal_peptide_metabolism0.62600620
86MP0003936_abnormal_reproductive_system0.62245125
87MP0001944_abnormal_pancreas_morphology0.60985602
88MP0004924_abnormal_behavior0.60757630
89MP0005386_behavior/neurological_phenoty0.60757630
90MP0002452_abnormal_antigen_presenting0.60672547
91MP0004381_abnormal_hair_follicle0.59913410
92MP0001919_abnormal_reproductive_system0.58986916
93MP0000685_abnormal_immune_system0.58302814
94MP0002396_abnormal_hematopoietic_system0.58241672
95MP0003111_abnormal_nucleus_morphology0.58222594
96MP0005671_abnormal_response_to0.58125126
97MP0003448_altered_tumor_morphology0.57979731
98MP0005275_abnormal_skin_tensile0.57747984
99MP0005000_abnormal_immune_tolerance0.57554270
100MP0003950_abnormal_plasma_membrane0.57038922
101MP0001324_abnormal_eye_pigmentation0.55812095
102MP0001851_eye_inflammation0.55014464
103MP0000013_abnormal_adipose_tissue0.54948543
104MP0001800_abnormal_humoral_immune0.51606200
105MP0002148_abnormal_hypersensitivity_rea0.50063744
106MP0003115_abnormal_respiratory_system0.48963172
107MP0005387_immune_system_phenotype0.48225770
108MP0001790_abnormal_immune_system0.48225770
109MP0004134_abnormal_chest_morphology0.47656455
110MP0003045_fibrosis0.46190722
111MP0001819_abnormal_immune_cell0.44895562
112MP0002420_abnormal_adaptive_immunity0.44595863
113MP0003878_abnormal_ear_physiology0.43863402
114MP0005377_hearing/vestibular/ear_phenot0.43863402
115MP0003303_peritoneal_inflammation0.43664033
116MP0004510_myositis0.43027793
117MP0000358_abnormal_cell_content/0.42809924
118MP0001293_anophthalmia0.41716476
119MP0003011_delayed_dark_adaptation0.40899744
120MP0001119_abnormal_female_reproductive0.40885914
121MP0005464_abnormal_platelet_physiology0.40809796
122MP0000313_abnormal_cell_death0.40756750
123MP0003699_abnormal_female_reproductive0.40017327
124MP0003077_abnormal_cell_cycle0.38820646
125MP0002234_abnormal_pharynx_morphology0.37322266
126MP0003300_gastrointestinal_ulcer0.37283016
127MP0000604_amyloidosis0.37104183
128MP0002398_abnormal_bone_marrow0.36850008
129MP0000427_abnormal_hair_cycle0.36694270
130MP0008469_abnormal_protein_level0.36458768
131MP0001845_abnormal_inflammatory_respons0.35743807
132MP0002254_reproductive_system_inflammat0.35470207
133MP0001764_abnormal_homeostasis0.33567749
134MP0009115_abnormal_fat_cell0.33349685
135MP0001853_heart_inflammation0.32110626
136MP0000716_abnormal_immune_system0.31990043
137MP0005636_abnormal_mineral_homeostasis0.31500675
138MP0003172_abnormal_lysosome_physiology0.30204605
139MP0003943_abnormal_hepatobiliary_system0.30015675
140MP0000858_altered_metastatic_potential0.27972976
141MP0000689_abnormal_spleen_morphology0.27866972
142MP0002971_abnormal_brown_adipose0.26235546
143MP0005257_abnormal_intraocular_pressure0.25827512
144MP0000371_diluted_coat_color0.25776174
145MP0000703_abnormal_thymus_morphology0.23901174
146MP0000733_abnormal_muscle_development0.22589442
147MP0009763_increased_sensitivity_to0.22412804
148MP0002429_abnormal_blood_cell0.22392366
149MP0001730_embryonic_growth_arrest0.21731777

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.12891030
2Abnormal respiratory motile cilium morphology (HP:0005938)8.80095489
3Abnormal respiratory epithelium morphology (HP:0012253)8.80095489
4Rhinitis (HP:0012384)7.73626450
5Abnormal ciliary motility (HP:0012262)7.28155687
6Chronic bronchitis (HP:0004469)7.10372167
7Nasal polyposis (HP:0100582)6.37979703
8Oligodactyly (hands) (HP:0001180)6.01186220
9Infertility (HP:0000789)5.95765996
10Volvulus (HP:0002580)5.34735668
11Abnormality of the nasal mucosa (HP:0000433)5.20879462
12Bronchiectasis (HP:0002110)4.56445888
13Bronchitis (HP:0012387)4.41459252
14Shoulder girdle muscle weakness (HP:0003547)4.36400696
15Nephronophthisis (HP:0000090)4.27333678
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.90424360
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.90424360
18Congenital, generalized hypertrichosis (HP:0004540)3.86726977
19Abnormality of the nasal septum (HP:0000419)3.76112555
20Abnormality of the pons (HP:0007361)3.72826322
21Hypoplasia of the pons (HP:0012110)3.69719410
22Follicular hyperkeratosis (HP:0007502)3.69234805
23Oligodactyly (HP:0012165)3.59215899
24Recurrent sinusitis (HP:0011108)3.54857647
25Spontaneous abortion (HP:0005268)3.41387075
26Male infertility (HP:0003251)3.38637717
27Abnormality of the renal medulla (HP:0100957)3.26973320
28Recurrent otitis media (HP:0000403)3.26848400
29Hyperglycinemia (HP:0002154)3.22716094
30Abnormal spermatogenesis (HP:0008669)3.05882127
31Rimmed vacuoles (HP:0003805)3.04560065
32Abnormality of the corticospinal tract (HP:0002492)2.87841247
33Fair hair (HP:0002286)2.86578885
34Pili torti (HP:0003777)2.84228534
35Tubulointerstitial nephritis (HP:0001970)2.79751486
36Hip dysplasia (HP:0001385)2.76929017
37Abnormality of the lower motor neuron (HP:0002366)2.73855999
38Medial flaring of the eyebrow (HP:0010747)2.68354303
39Tubular atrophy (HP:0000092)2.67567887
40Recurrent bronchitis (HP:0002837)2.62183976
41Widely spaced teeth (HP:0000687)2.61941911
42Molar tooth sign on MRI (HP:0002419)2.59750184
43Abnormality of midbrain morphology (HP:0002418)2.59750184
44Aplasia of the musculature (HP:0100854)2.56930113
45Capillary hemangiomas (HP:0005306)2.53439078
46Spondylolisthesis (HP:0003302)2.48004615
47Aplasia/Hypoplasia involving the musculature (HP:0001460)2.47436204
48Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.45593507
49Chronic diarrhea (HP:0002028)2.43855658
50Methylmalonic acidemia (HP:0002912)2.40801110
51Genetic anticipation (HP:0003743)2.38954147
52Azoospermia (HP:0000027)2.38387079
53Tubulointerstitial abnormality (HP:0001969)2.38337760
54Gonadotropin excess (HP:0000837)2.37458157
55Impulsivity (HP:0100710)2.36904639
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.29644934
57Generalized hypopigmentation of hair (HP:0011358)2.27623297
58Short tibia (HP:0005736)2.22690283
59Fibular hypoplasia (HP:0003038)2.20601646
60Horizontal nystagmus (HP:0000666)2.16702635
61Absent frontal sinuses (HP:0002688)2.16626537
62Bile duct proliferation (HP:0001408)2.15661253
63Hip contracture (HP:0003273)2.15280784
64Abnormality of the shoulder girdle musculature (HP:0001435)2.14979746
65Lip pit (HP:0100267)2.14155876
66Abnormality of the phalanges of the 5th finger (HP:0004213)2.12416753
67Neoplasm of the tracheobronchial system (HP:0100552)2.12172354
68Congenital stationary night blindness (HP:0007642)2.11617300
69Impaired proprioception (HP:0010831)2.09786956
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09402986
71Abnormal protein N-linked glycosylation (HP:0012347)2.09402986
72Abnormal protein glycosylation (HP:0012346)2.09402986
73Abnormal glycosylation (HP:0012345)2.09402986
74Amyotrophic lateral sclerosis (HP:0007354)2.08456370
75Abnormal pancreas size (HP:0012094)2.06876582
76Proximal placement of thumb (HP:0009623)2.05341379
77Hypoplastic labia majora (HP:0000059)2.04947611
78Upper motor neuron abnormality (HP:0002127)2.03680678
79Pancreatic cysts (HP:0001737)2.03295050
80Truncal obesity (HP:0001956)2.01291761
81Knee flexion contracture (HP:0006380)2.00842985
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1794238
83Dynein arm defect of respiratory motile cilia (HP:0012255)12.4577892
84Absent/shortened dynein arms (HP:0200106)12.4577892
85Hypoplasia of the uterus (HP:0000013)1.98815164
86Abnormality of chromosome stability (HP:0003220)1.97667124
87Atrophy/Degeneration involving motor neurons (HP:0007373)1.97378055
88Chronic sinusitis (HP:0011109)1.95526076
89Protruding tongue (HP:0010808)1.93716999
90Aplasia/hypoplasia of the uterus (HP:0008684)1.93690680
91Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93182585
92Retrobulbar optic neuritis (HP:0100654)1.92252606
93Optic neuritis (HP:0100653)1.92252606
94Congenital hepatic fibrosis (HP:0002612)1.91762055
95Deviation of the thumb (HP:0009603)1.91167011
96Abnormality of the renal cortex (HP:0011035)1.89232363
97Tubulointerstitial fibrosis (HP:0005576)1.89219909
98Alveolar cell carcinoma (HP:0006519)1.88525867
99Gaze-evoked nystagmus (HP:0000640)1.88132786
100Abnormality of the labia majora (HP:0012881)1.87184382
101Postaxial foot polydactyly (HP:0001830)1.86135980
102Heterotopia (HP:0002282)1.85656151
103Stage 5 chronic kidney disease (HP:0003774)1.85532009
104Stomach cancer (HP:0012126)1.80522006
105Oculomotor apraxia (HP:0000657)1.79973238
106Hematochezia (HP:0002573)1.79192129
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78173302
108Embryonal renal neoplasm (HP:0011794)1.78149452
109Intestinal atresia (HP:0011100)1.78132693
110Nephroblastoma (Wilms tumor) (HP:0002667)1.75054029
111Enlarged penis (HP:0000040)1.74582806
112Abnormality of the columella (HP:0009929)1.74028381
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.73791334
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73235488
115Albinism (HP:0001022)1.73076557
116Type I transferrin isoform profile (HP:0003642)1.72077534
117Hypoplastic iliac wings (HP:0002866)1.72069984
118Hypoplasia of the radius (HP:0002984)1.70266688
119Facial hemangioma (HP:0000329)1.67579292
120Type I diabetes mellitus (HP:0100651)1.67400376
121Urinary bladder sphincter dysfunction (HP:0002839)1.67197088
122Abnormality of the dental root (HP:0006486)1.67106868
123Taurodontia (HP:0000679)1.67106868
124Abnormality of permanent molar morphology (HP:0011071)1.67106868
125Dyskinesia (HP:0100660)1.66913424
126Clumsiness (HP:0002312)1.66721996
127Orchitis (HP:0100796)1.64325679
128Abnormality of the vocal cords (HP:0008777)1.62841720
129Keratoconjunctivitis (HP:0001096)1.62768470
130Limb-girdle muscle weakness (HP:0003325)1.62370649
131Difficulty running (HP:0009046)1.61646201
132Short ribs (HP:0000773)1.61516124
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60930277
134Polydipsia (HP:0001959)1.60374936
135Abnormal drinking behavior (HP:0030082)1.60374936
136Abnormality of molar morphology (HP:0011070)1.56883825
137Abnormality of molar (HP:0011077)1.56883825
138Bell-shaped thorax (HP:0001591)1.55540351
139Abnormality of the dental pulp (HP:0006479)1.55432168
140Degeneration of anterior horn cells (HP:0002398)1.55311784
141Abnormality of the anterior horn cell (HP:0006802)1.55311784
142Renal dysplasia (HP:0000110)1.54317506
143Congenital primary aphakia (HP:0007707)1.52405004
144J-shaped sella turcica (HP:0002680)1.51629095
145Spastic tetraparesis (HP:0001285)1.51514757
146Dyschromatopsia (HP:0007641)1.48260294
147Gait imbalance (HP:0002141)1.47984872
148Nephropathy (HP:0000112)1.47415425
149Hypoplasia of dental enamel (HP:0006297)1.47336668
150Postaxial hand polydactyly (HP:0001162)1.46914684
151Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.46743461
152Abnormality of renal excretion (HP:0011036)1.46106343
153Median cleft lip (HP:0000161)1.44804427
154Facial cleft (HP:0002006)1.40806971
155Aplasia/Hypoplasia of the lens (HP:0008063)1.40246306
156Deformed sella turcica (HP:0002681)1.39512863
157Absent epiphyses (HP:0010577)1.38180731
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38180731
159Supernumerary spleens (HP:0009799)1.35781493
160Microglossia (HP:0000171)1.34683232
161Abnormality of dentin (HP:0010299)1.33488632
162Nephrogenic diabetes insipidus (HP:0009806)1.32837849
163Abnormality of ocular smooth pursuit (HP:0000617)1.31004155
164Conjunctival telangiectasia (HP:0000524)1.30585412
165Breast carcinoma (HP:0003002)1.30315340
166Choroideremia (HP:0001139)1.30060186
167Abnormality of saccadic eye movements (HP:0000570)1.30038634
168Short thorax (HP:0010306)1.29690062
169Decreased motor nerve conduction velocity (HP:0003431)1.29020117
170Hemorrhage of the eye (HP:0011885)1.26942857
171Cystic liver disease (HP:0006706)1.26063142
172Aplasia/Hypoplasia of the fibula (HP:0006492)1.25996794
173Abnormality of the frontal sinuses (HP:0002687)1.24641189
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.24498447
175Myositis (HP:0100614)1.24399379
176Recurrent abscess formation (HP:0002722)1.20880138
177Vascular calcification (HP:0004934)1.20817707
178Recurrent bacterial skin infections (HP:0005406)1.19031713
179Ectopic kidney (HP:0000086)1.18854826
180Abnormal biliary tract physiology (HP:0012439)1.18389906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.99728381
2PDK48.99728381
3PDK25.92280450
4TESK14.54498374
5AKT34.11572723
6PRKD33.39371590
7FRK3.38183277
8ZAK3.32094969
9ICK3.21177942
10ACVR1B2.71566491
11STK38L2.64641084
12TLK12.54629663
13PTK2B2.41357143
14NEK22.12613182
15NLK2.06710563
16PNCK1.98265846
17LIMK11.85782160
18WNK41.82717161
19STK391.72953830
20EIF2AK31.54444693
21BUB11.50595592
22MET1.44552862
23GRK71.35155337
24OXSR11.34698824
25MST41.28217605
26STK381.22521665
27CDK191.20230777
28FGFR31.19781162
29RIPK41.16663837
30PLK21.14700520
31STK31.14393413
32MELK1.13147515
33CDK121.12421053
34BRD41.09266518
35PIM21.05138465
36GRK11.04609536
37RPS6KA51.03963066
38TRIM281.02088553
39SGK21.00763295
40PDK10.96625177
41NEK90.96327662
42STK160.95689568
43MAPK150.94296342
44DYRK1B0.91768989
45MKNK20.90136556
46WNK10.87780709
47CDK30.84923769
48MOS0.83682030
49IRAK10.80013283
50CCNB10.75784559
51RAF10.75379682
52CDC70.74695231
53ADRBK20.71765996
54TRPM70.71014042
55MAP3K140.70950958
56ARAF0.69821338
57CDK80.69117950
58MYLK0.68730225
59KSR10.68721780
60MAPK110.68685019
61CAMK1G0.67364913
62PLK40.64737024
63MAP4K20.63102589
64TTK0.62690446
65ATR0.62417064
66MAP3K130.58893370
67TBK10.57535177
68TYRO30.57528558
69BMX0.56834354
70CHEK20.55351754
71SGK10.54858139
72DYRK30.54629028
73FGR0.52850290
74TGFBR20.52190628
75ABL10.51271601
76PASK0.50940082
77CHEK10.49162756
78LMTK20.46480485
79BRAF0.45762992
80SGK30.45662926
81BMPR20.43090763
82ATM0.42787639
83ADRBK10.41474971
84SIK30.40275321
85PRKCI0.39789427
86MARK30.39567042
87PIK3CG0.39178659
88TGFBR10.39058419
89MAP4K10.38498027
90ZAP700.38295534
91PDPK10.37382495
92WEE10.37336155
93MTOR0.36886576
94IGF1R0.36060522
95ERBB40.35702489
96DYRK1A0.35624253
97IKBKE0.35128009
98MAP2K60.34543166
99MAP3K100.33100002
100NUAK10.32662264
101CDK60.31770543
102MAPKAPK20.31168509
103IKBKB0.30803794
104PRKCE0.30661222
105TYK20.30620991
106CSF1R0.30609242
107AURKA0.30313981
108SGK2230.29966776
109RIPK10.27283226
110PINK10.26901803
111IRAK20.26252681
112KIT0.25229301
113TXK0.24569182
114CHUK0.23594013
115YES10.23277089
116TTN0.21477660
117PLK10.21371093
118PDGFRB0.21074001
119PIM10.20243649
120RPS6KA40.20007666
121CSK0.19823826
122PAK10.18476797
123NEK60.18451667
124EGFR0.17944000
125PAK20.17481707
126PBK0.16586545
127BRSK20.16102804
128MAP3K50.15864813
129MARK20.15630006
130JAK10.15433856
131TAOK30.15314135
132STK100.15161246
133PRKAA10.14717566
134JAK30.13942880
135EPHB10.13852555
136TESK20.13801199
137CDK40.13349110
138MAP3K30.11400296
139HCK0.11320944
140PRKCQ0.10117091
141LCK0.08937825
142RPS6KB10.08585668
143PKN10.08529771
144RPS6KA10.08264506
145BMPR1B0.06886302
146CAMKK10.06753876
147SIK20.06446765
148MAPK80.05452931
149PRKDC0.05275234
150PAK40.05178466
151EEF2K0.05122919
152CDK20.04916617
153GSK3A0.04890385
154MAPK100.04741950
155CSNK1D0.04676706
156PRKCD0.04499057
157MAPKAPK50.04497113
158GSK3B0.04470647
159STK40.04378673
160IRAK40.04275439

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.24071592
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.47515540
3Pyruvate metabolism_Homo sapiens_hsa006203.09287124
4Regulation of autophagy_Homo sapiens_hsa041402.89068621
5Fatty acid biosynthesis_Homo sapiens_hsa000612.79438199
6Sulfur relay system_Homo sapiens_hsa041222.72921506
7Selenocompound metabolism_Homo sapiens_hsa004502.61166727
8Basal transcription factors_Homo sapiens_hsa030222.52470176
9Fanconi anemia pathway_Homo sapiens_hsa034602.44889238
10Glucagon signaling pathway_Homo sapiens_hsa049222.39084912
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28837315
12Dorso-ventral axis formation_Homo sapiens_hsa043202.27070388
13Propanoate metabolism_Homo sapiens_hsa006402.21071179
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.15586211
15p53 signaling pathway_Homo sapiens_hsa041152.15130672
16Linoleic acid metabolism_Homo sapiens_hsa005912.05289643
17Legionellosis_Homo sapiens_hsa051341.99587173
18Circadian rhythm_Homo sapiens_hsa047101.98260720
19Pentose phosphate pathway_Homo sapiens_hsa000301.96638460
20Primary immunodeficiency_Homo sapiens_hsa053401.94185270
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91051592
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.88620285
23Cell cycle_Homo sapiens_hsa041101.75704737
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69244339
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62576430
26Glycerolipid metabolism_Homo sapiens_hsa005611.60055173
27RNA degradation_Homo sapiens_hsa030181.59544083
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59014208
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.56811445
30Autoimmune thyroid disease_Homo sapiens_hsa053201.56412259
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51349409
32Antigen processing and presentation_Homo sapiens_hsa046121.49177994
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48348031
34Graft-versus-host disease_Homo sapiens_hsa053321.46809529
35Oocyte meiosis_Homo sapiens_hsa041141.46169598
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41688305
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.40976013
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.40376449
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38413711
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33033199
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31276015
42PPAR signaling pathway_Homo sapiens_hsa033201.26837260
43Nitrogen metabolism_Homo sapiens_hsa009101.26118274
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25387322
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24860015
46B cell receptor signaling pathway_Homo sapiens_hsa046621.22680921
47Mismatch repair_Homo sapiens_hsa034301.21033540
48Influenza A_Homo sapiens_hsa051641.20670902
49Osteoclast differentiation_Homo sapiens_hsa043801.19488240
50Measles_Homo sapiens_hsa051621.19449900
51Mineral absorption_Homo sapiens_hsa049781.16042573
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12976613
53Malaria_Homo sapiens_hsa051441.09517972
54Glycerophospholipid metabolism_Homo sapiens_hsa005641.07750147
55Non-homologous end-joining_Homo sapiens_hsa034501.05687833
56ABC transporters_Homo sapiens_hsa020101.05533208
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.04030657
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02052215
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01628594
60FoxO signaling pathway_Homo sapiens_hsa040681.01145779
61Phototransduction_Homo sapiens_hsa047440.97761446
62Fructose and mannose metabolism_Homo sapiens_hsa000510.96931917
63Renin secretion_Homo sapiens_hsa049240.95035975
64Toxoplasmosis_Homo sapiens_hsa051450.92686321
65African trypanosomiasis_Homo sapiens_hsa051430.91825402
66Ether lipid metabolism_Homo sapiens_hsa005650.91288540
67Salmonella infection_Homo sapiens_hsa051320.90146168
68mRNA surveillance pathway_Homo sapiens_hsa030150.89320252
69Small cell lung cancer_Homo sapiens_hsa052220.88846859
70TNF signaling pathway_Homo sapiens_hsa046680.88611278
71DNA replication_Homo sapiens_hsa030300.87648408
72TGF-beta signaling pathway_Homo sapiens_hsa043500.86838167
73Pyrimidine metabolism_Homo sapiens_hsa002400.86462382
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.84258118
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83756854
76Amphetamine addiction_Homo sapiens_hsa050310.83643100
77Apoptosis_Homo sapiens_hsa042100.82657352
78Proteasome_Homo sapiens_hsa030500.82412062
79Systemic lupus erythematosus_Homo sapiens_hsa053220.81279388
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.81246428
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80187069
82Rheumatoid arthritis_Homo sapiens_hsa053230.78836314
83RNA transport_Homo sapiens_hsa030130.77444482
84Prostate cancer_Homo sapiens_hsa052150.77114228
85Collecting duct acid secretion_Homo sapiens_hsa049660.74920654
86Inositol phosphate metabolism_Homo sapiens_hsa005620.74724734
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74061311
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73977982
89Herpes simplex infection_Homo sapiens_hsa051680.72764577
90T cell receptor signaling pathway_Homo sapiens_hsa046600.72053567
91Fat digestion and absorption_Homo sapiens_hsa049750.71289219
92Butanoate metabolism_Homo sapiens_hsa006500.70673256
93Leishmaniasis_Homo sapiens_hsa051400.70586613
94beta-Alanine metabolism_Homo sapiens_hsa004100.70456922
95Allograft rejection_Homo sapiens_hsa053300.69633606
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68762119
97Huntingtons disease_Homo sapiens_hsa050160.67623341
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66747703
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64645788
100Base excision repair_Homo sapiens_hsa034100.64206016
101VEGF signaling pathway_Homo sapiens_hsa043700.62732089
102Tuberculosis_Homo sapiens_hsa051520.61775977
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.59766909
104Viral carcinogenesis_Homo sapiens_hsa052030.59254101
105Homologous recombination_Homo sapiens_hsa034400.59160522
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59066364
107Estrogen signaling pathway_Homo sapiens_hsa049150.58218266
108Renin-angiotensin system_Homo sapiens_hsa046140.57260481
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55462777
110Carbon metabolism_Homo sapiens_hsa012000.55156104
111Purine metabolism_Homo sapiens_hsa002300.54529039
112Nucleotide excision repair_Homo sapiens_hsa034200.53478979
113Hedgehog signaling pathway_Homo sapiens_hsa043400.53126963
114Phagosome_Homo sapiens_hsa041450.52820614
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52160740
116Glutathione metabolism_Homo sapiens_hsa004800.51672327
117Hepatitis B_Homo sapiens_hsa051610.50735226
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50107818
119Hematopoietic cell lineage_Homo sapiens_hsa046400.49790052
120Epstein-Barr virus infection_Homo sapiens_hsa051690.49344250
121Staphylococcus aureus infection_Homo sapiens_hsa051500.48637892
122mTOR signaling pathway_Homo sapiens_hsa041500.48159496
123Asthma_Homo sapiens_hsa053100.47864101
124Taste transduction_Homo sapiens_hsa047420.47036149
125Pertussis_Homo sapiens_hsa051330.46004662
126Type II diabetes mellitus_Homo sapiens_hsa049300.45838819
127Hepatitis C_Homo sapiens_hsa051600.45031659
128Arachidonic acid metabolism_Homo sapiens_hsa005900.42674944
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.42129444
130Endocytosis_Homo sapiens_hsa041440.42014730
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.40872584
132Chemical carcinogenesis_Homo sapiens_hsa052040.40056443
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39452831
134HTLV-I infection_Homo sapiens_hsa051660.39158841
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38003585
136Viral myocarditis_Homo sapiens_hsa054160.36817658
137MAPK signaling pathway_Homo sapiens_hsa040100.36180046
138HIF-1 signaling pathway_Homo sapiens_hsa040660.35891696
139Prolactin signaling pathway_Homo sapiens_hsa049170.34857312
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34578741
141Type I diabetes mellitus_Homo sapiens_hsa049400.34190957
142Insulin resistance_Homo sapiens_hsa049310.33230956
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31992479
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31646442
145Lysine degradation_Homo sapiens_hsa003100.30845116
146Alcoholism_Homo sapiens_hsa050340.30376223
147Spliceosome_Homo sapiens_hsa030400.30299577
148AMPK signaling pathway_Homo sapiens_hsa041520.30024749
149Calcium signaling pathway_Homo sapiens_hsa040200.29206835
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28286774
151Folate biosynthesis_Homo sapiens_hsa007900.28217400
152Olfactory transduction_Homo sapiens_hsa047400.28214205
153Shigellosis_Homo sapiens_hsa051310.26940628

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