EHD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.22729427
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.13125249
3cardiac myofibril assembly (GO:0055003)5.79455460
4negative regulation of potassium ion transmembrane transport (GO:1901380)5.19351768
5myofibril assembly (GO:0030239)5.10461591
6muscle filament sliding (GO:0030049)4.60190321
7actin-myosin filament sliding (GO:0033275)4.60190321
8plasma membrane repair (GO:0001778)4.58832284
9cardiac muscle cell development (GO:0055013)4.30192515
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.24257512
11cardiac cell development (GO:0055006)4.06665323
12cardiac muscle contraction (GO:0060048)3.95879875
13ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.89803116
14actomyosin structure organization (GO:0031032)3.89025706
15cardiac muscle tissue morphogenesis (GO:0055008)3.88748859
16actin-mediated cell contraction (GO:0070252)3.79673323
17vascular endothelial growth factor signaling pathway (GO:0038084)3.76582255
18regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.74785956
19regulation of relaxation of muscle (GO:1901077)3.73050613
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.71006213
21heart trabecula formation (GO:0060347)3.70644993
22regulation of actin filament-based movement (GO:1903115)3.69474652
23regulation of interferon-beta biosynthetic process (GO:0045357)3.64136179
24regulation of cardioblast differentiation (GO:0051890)3.56984121
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53028800
26barbed-end actin filament capping (GO:0051016)3.50440694
27muscle tissue morphogenesis (GO:0060415)3.47633239
28regulation of sarcomere organization (GO:0060297)3.47364483
29regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.46341490
30positive regulation by symbiont of host defense response (GO:0052509)3.46030548
31modulation by symbiont of host defense response (GO:0052031)3.46030548
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46030548
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46030548
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.46030548
35modulation by symbiont of host immune response (GO:0052553)3.46030548
36regulation of skeletal muscle contraction (GO:0014819)3.43190836
37cytidine metabolic process (GO:0046087)3.42864225
38cytidine catabolic process (GO:0006216)3.42864225
39cytidine deamination (GO:0009972)3.42864225
40cardiac muscle hypertrophy (GO:0003300)3.37753369
41NIK/NF-kappaB signaling (GO:0038061)3.35895575
42ventricular cardiac muscle cell action potential (GO:0086005)3.34045873
43regulation of vitamin D biosynthetic process (GO:0060556)3.32434795
44type I interferon signaling pathway (GO:0060337)3.27157040
45cellular response to type I interferon (GO:0071357)3.27157040
46response to type I interferon (GO:0034340)3.23375104
47heart contraction (GO:0060047)3.15756957
48heart process (GO:0003015)3.15756957
49surfactant homeostasis (GO:0043129)3.15611291
50striated muscle hypertrophy (GO:0014897)3.15553056
51positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.15404309
52negative regulation of interleukin-12 production (GO:0032695)3.13994567
53actin filament-based movement (GO:0030048)3.12258709
54Golgi transport vesicle coating (GO:0048200)3.11708054
55COPI coating of Golgi vesicle (GO:0048205)3.11708054
56basement membrane organization (GO:0071711)3.11331146
57tricarboxylic acid cycle (GO:0006099)3.10934563
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08590318
59response to peptidoglycan (GO:0032494)3.07870693
60muscle hypertrophy (GO:0014896)3.05818500
61angiogenesis involved in wound healing (GO:0060055)3.05326187
62myeloid dendritic cell differentiation (GO:0043011)3.05171786
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.05082843
64regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.04900847
65establishment of endothelial barrier (GO:0061028)3.02539791
66positive regulation of interferon-alpha production (GO:0032727)3.01515263
67cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.00248232
68striated muscle contraction (GO:0006941)3.00085431
69hemidesmosome assembly (GO:0031581)2.98397480
70apoptotic cell clearance (GO:0043277)2.98081843
71regulation of the force of heart contraction (GO:0002026)2.93003763
72regulation of striated muscle contraction (GO:0006942)2.92535781
73regulation of p38MAPK cascade (GO:1900744)2.91334028
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88778948
75endothelial tube morphogenesis (GO:0061154)2.88647628
76morphogenesis of an endothelium (GO:0003159)2.88647628
77endothelium development (GO:0003158)2.88282228
78regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87387328
79fibroblast migration (GO:0010761)2.86024042
80adult heart development (GO:0007512)2.84543659
81pyrimidine ribonucleoside catabolic process (GO:0046133)2.84529948
82virion attachment to host cell (GO:0019062)2.84430877
83adhesion of symbiont to host cell (GO:0044650)2.84430877
84sarcoplasmic reticulum calcium ion transport (GO:0070296)2.83679532
85positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.83475189
86protein localization to endosome (GO:0036010)2.83175252
87positive regulation of macrophage cytokine production (GO:0060907)2.82667735
88negative regulation of cardiac muscle tissue growth (GO:0055022)2.82424262
89negative regulation of heart growth (GO:0061117)2.82424262
90regulation of interferon-alpha production (GO:0032647)2.81790194
91blood vessel maturation (GO:0001955)2.81565132
92fatty acid transmembrane transport (GO:1902001)2.78663718
93regulation of vitamin metabolic process (GO:0030656)2.78321629
94regulation of mononuclear cell migration (GO:0071675)2.78300414
95carnitine shuttle (GO:0006853)2.78181896
96retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77131992
97stress fiber assembly (GO:0043149)2.76903341
98T-helper 1 type immune response (GO:0042088)2.76591664
99venous blood vessel morphogenesis (GO:0048845)2.72934732
100epithelial cell-cell adhesion (GO:0090136)2.72402885
101skin morphogenesis (GO:0043589)2.72015885
102glycosphingolipid catabolic process (GO:0046479)2.70898563
103negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.70617300
104regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.68710083
105regulation of membrane protein ectodomain proteolysis (GO:0051043)2.67556945
106regulation of endothelial cell differentiation (GO:0045601)2.67496075
107adhesion of symbiont to host (GO:0044406)2.66526013
108daunorubicin metabolic process (GO:0044597)2.66037123
109polyketide metabolic process (GO:0030638)2.66037123
110doxorubicin metabolic process (GO:0044598)2.66037123
111interferon-gamma-mediated signaling pathway (GO:0060333)2.65712800
112positive regulation of p38MAPK cascade (GO:1900745)2.65184571
113relaxation of cardiac muscle (GO:0055119)2.64146038
114positive regulation of endothelial cell apoptotic process (GO:2000353)2.64133611
115antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.63635137
116negative regulation of nitric-oxide synthase activity (GO:0051001)2.62384288
117atrioventricular valve morphogenesis (GO:0003181)2.61579753
118cellular response to zinc ion (GO:0071294)2.61511644
119macrophage activation involved in immune response (GO:0002281)2.61295389
120trabecula morphogenesis (GO:0061383)2.61010778
121immunoglobulin mediated immune response (GO:0016064)2.60745983
122regulation of podosome assembly (GO:0071801)2.60534804
123regulation of transforming growth factor beta1 production (GO:0032908)2.60274775
124phagocytosis, recognition (GO:0006910)2.60195865
125response to muramyl dipeptide (GO:0032495)2.59608020
126negative regulation of potassium ion transport (GO:0043267)2.59490421
127antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58266054
128positive regulation of Cdc42 GTPase activity (GO:0043089)2.58076847
129wound healing, spreading of epidermal cells (GO:0035313)2.56753131
130glomerular visceral epithelial cell development (GO:0072015)2.56617498
131regulation of early endosome to late endosome transport (GO:2000641)2.56352746
132regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56283046
133germinal center formation (GO:0002467)2.55701320
134regulation of tight junction assembly (GO:2000810)2.54319373
135membrane raft organization (GO:0031579)2.54235351
136cellular response to interferon-alpha (GO:0035457)2.53223580
137regulation of cardiac muscle cell contraction (GO:0086004)2.52571156
138regulation of macrophage cytokine production (GO:0010935)2.51767271
139myeloid dendritic cell activation (GO:0001773)2.51665661
140regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.51082456
141regulation of integrin activation (GO:0033623)2.50300785
142glycolipid catabolic process (GO:0019377)2.49677874
143striated muscle atrophy (GO:0014891)2.48951760
144hyaluronan catabolic process (GO:0030214)2.48802298
145cell-substrate junction assembly (GO:0007044)2.47681283
146regulation of sequestering of triglyceride (GO:0010889)2.47087154
147low-density lipoprotein particle clearance (GO:0034383)2.45772693
148cell adhesion mediated by integrin (GO:0033627)2.45105333
149regulation of T-helper 1 cell differentiation (GO:0045625)2.44208475
150negative regulation of nitric oxide biosynthetic process (GO:0045019)2.43780252
151wound healing, spreading of cells (GO:0044319)2.43594919
152substrate-dependent cell migration (GO:0006929)2.43089505
153activation of MAPKKK activity (GO:0000185)2.39566598
154positive regulation of chemokine biosynthetic process (GO:0045080)2.38725686
155vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.38686242
156response to progesterone (GO:0032570)2.38247385
157* pinocytosis (GO:0006907)2.37775092
158modulation by symbiont of host cellular process (GO:0044068)2.37766680
159dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37004724
160endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.35451107
161antigen processing and presentation of endogenous antigen (GO:0019883)2.33887367
162response to laminar fluid shear stress (GO:0034616)2.31904912
163regulation of cytokine secretion involved in immune response (GO:0002739)2.31698764
164regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.31691868
165dendritic cell differentiation (GO:0097028)2.30765983
166decidualization (GO:0046697)2.28187187
167regulation of macrophage chemotaxis (GO:0010758)2.28056313
168hypotonic response (GO:0006971)2.27599448
169positive regulation of type 2 immune response (GO:0002830)2.25725173
170positive regulation of receptor recycling (GO:0001921)2.25669546
171detection of other organism (GO:0098543)2.25160241
172cellular response to thyroid hormone stimulus (GO:0097067)2.24364634
173regulation of antigen processing and presentation (GO:0002577)2.22578706
174negative regulation of focal adhesion assembly (GO:0051895)2.21952920
175negative regulation of cell junction assembly (GO:1901889)2.21952920
176negative regulation of adherens junction organization (GO:1903392)2.21952920
177regulation of response to interferon-gamma (GO:0060330)2.21632587
178CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.21461227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.40721950
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.38747787
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.01262348
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00196528
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.81863198
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54784701
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.48513728
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42660062
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.38953510
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34050353
11GATA2_21666600_ChIP-Seq_HMVEC_Human2.29462211
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28628047
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.28331752
14* TBX20_22328084_ChIP-Seq_HEART_Mouse2.19509317
15* TBX20_22080862_ChIP-Seq_HEART_Mouse2.19509317
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.15085338
17* ELK3_25401928_ChIP-Seq_HUVEC_Human2.08759345
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08181049
19GATA1_22025678_ChIP-Seq_K562_Human2.02758456
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00392936
21CLOCK_20551151_ChIP-Seq_293T_Human1.98804632
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97932024
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93345503
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92496424
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.90749417
26* EP300_21415370_ChIP-Seq_HL-1_Mouse1.89309353
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82694083
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80843121
29* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78970399
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78908760
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75304109
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.75003818
33* SPI1_23127762_ChIP-Seq_K562_Human1.73233241
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70627552
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70207594
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65747101
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64407849
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.61842152
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.61385190
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56874787
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.55480802
42TCF7_22412390_ChIP-Seq_EML_Mouse1.54383241
43* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52922214
44VDR_21846776_ChIP-Seq_THP-1_Human1.49928923
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47264403
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47264403
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47264403
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.47159820
49SCL_19346495_ChIP-Seq_HPC-7_Human1.45991827
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.44603210
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43776402
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43014626
53* MAF_26560356_Chip-Seq_TH1_Human1.42095451
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39011652
55KDM2B_26808549_Chip-Seq_DND41_Human1.38552984
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37902815
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34517219
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34432575
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32863838
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31706631
61* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30618387
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28783820
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27875370
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27383081
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.27057445
66* RACK7_27058665_Chip-Seq_MCF-7_Human1.26764221
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26535304
68ZNF263_19887448_ChIP-Seq_K562_Human1.26080330
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24858493
70ATF3_27146783_Chip-Seq_COLON_Human1.24672464
71MYC_22102868_ChIP-Seq_BL_Human1.23816950
72MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23276620
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21995208
74* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21851345
75GATA1_19941826_ChIP-Seq_K562_Human1.21397912
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19450742
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19450742
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19396176
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15969977
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15868817
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14629392
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14485283
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12915887
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12473354
85VDR_24763502_ChIP-Seq_THP-1_Human1.12273353
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11751492
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11308728
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11077604
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10970535
90SPI1_23547873_ChIP-Seq_NB4_Human1.10393252
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10249367
92* NCOR1_26117541_ChIP-Seq_K562_Human1.10038936
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10001428
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08985130
95LXR_22292898_ChIP-Seq_THP-1_Human1.08551063
96CJUN_26792858_Chip-Seq_BT549_Human1.08082212
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07892196
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07644617
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07462048
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07261398
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.06811618
102PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03814844
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03650233
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03639922
105TP53_22127205_ChIP-Seq_IMR90_Human1.03564487
106UTX_26944678_Chip-Seq_JUKART_Human1.03521138
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03346507
108RXR_22158963_ChIP-Seq_LIVER_Mouse1.02840671
109SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02002877
110GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01872787
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01618136
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01608580
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01511726
114SOX2_20726797_ChIP-Seq_SW620_Human1.00635363
115P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00061385
116TFEB_21752829_ChIP-Seq_HELA_Human1.00015869
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99810794
118RUNX_20019798_ChIP-Seq_JUKART_Human0.99174014
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99071839
120MYB_26560356_Chip-Seq_TH2_Human0.98593003
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97717033
122* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96605079
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96571623
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.96418533
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96025712
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95946583
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94555072
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94373342
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92926306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.71836702
2MP0002837_dystrophic_cardiac_calcinosis3.55685218
3MP0003828_pulmonary_edema3.14308441
4MP0000751_myopathy3.06495040
5MP0004215_abnormal_myocardial_fiber2.94184431
6MP0004036_abnormal_muscle_relaxation2.93380740
7MP0005330_cardiomyopathy2.82699010
8MP0000749_muscle_degeneration2.76814861
9MP0010368_abnormal_lymphatic_system2.75853901
10MP0003646_muscle_fatigue2.72602554
11MP0004510_myositis2.47335754
12MP0000750_abnormal_muscle_regeneration2.44885662
13MP0008775_abnormal_heart_ventricle2.37574246
14MP0002972_abnormal_cardiac_muscle2.34549027
15MP0004087_abnormal_muscle_fiber2.30609243
16MP0003705_abnormal_hypodermis_morpholog2.28761816
17MP0010630_abnormal_cardiac_muscle2.25821559
18MP0010234_abnormal_vibrissa_follicle2.21663361
19MP0001544_abnormal_cardiovascular_syste2.19011850
20MP0005385_cardiovascular_system_phenoty2.19011850
21MP0003566_abnormal_cell_adhesion2.17839594
22MP0000343_altered_response_to2.16831870
23MP0006138_congestive_heart_failure1.97311771
24MP0005451_abnormal_body_composition1.97101840
25MP0003453_abnormal_keratinocyte_physiol1.86586877
26MP0004947_skin_inflammation1.84592271
27MP0001879_abnormal_lymphatic_vessel1.84133749
28MP0004484_altered_response_of1.80792421
29MP0002138_abnormal_hepatobiliary_system1.75310849
30MP0004130_abnormal_muscle_cell1.74148545
31MP0004272_abnormal_basement_membrane1.73947446
32MP0002106_abnormal_muscle_physiology1.72156159
33MP0005620_abnormal_muscle_contractility1.70852829
34MP0003303_peritoneal_inflammation1.68905689
35MP0003137_abnormal_impulse_conducting1.67359564
36MP0002332_abnormal_exercise_endurance1.66950245
37MP0005167_abnormal_blood-brain_barrier1.65883075
38MP0005257_abnormal_intraocular_pressure1.62896617
39MP0000858_altered_metastatic_potential1.60383232
40MP0003279_aneurysm1.60068098
41MP0008438_abnormal_cutaneous_collagen1.58453737
42MP0005671_abnormal_response_to1.57574396
43MP0000767_abnormal_smooth_muscle1.56347746
44MP0005058_abnormal_lysosome_morphology1.56051427
45MP0003950_abnormal_plasma_membrane1.55323058
46MP0002269_muscular_atrophy1.48210137
47MP0003221_abnormal_cardiomyocyte_apopto1.45496111
48MP0003075_altered_response_to1.45191782
49MP0002127_abnormal_cardiovascular_syste1.41684070
50MP0002796_impaired_skin_barrier1.39672390
51MP0001835_abnormal_antigen_presentation1.39160124
52MP0005165_increased_susceptibility_to1.37549152
53MP0004085_abnormal_heartbeat1.34931493
54MP0002723_abnormal_immune_serum1.33941991
55MP0001958_emphysema1.31579881
56MP0005369_muscle_phenotype1.31162599
57MP0003724_increased_susceptibility_to1.31079773
58MP0000759_abnormal_skeletal_muscle1.29083452
59MP0001849_ear_inflammation1.26260666
60MP0000465_gastrointestinal_hemorrhage1.24760474
61MP0010352_gastrointestinal_tract_polyps1.24298801
62MP0003436_decreased_susceptibility_to1.19758351
63MP0003191_abnormal_cellular_cholesterol1.18293093
64MP0001819_abnormal_immune_cell1.18239950
65MP0003300_gastrointestinal_ulcer1.17906779
66MP0001845_abnormal_inflammatory_respons1.17893694
67MP0002420_abnormal_adaptive_immunity1.17190992
68MP0008260_abnormal_autophagy1.16972401
69MP0003567_abnormal_fetal_cardiomyocyte1.15866972
70MP0000747_muscle_weakness1.14237386
71MP0006082_CNS_inflammation1.13537054
72MP0000266_abnormal_heart_morphology1.12388856
73MP0002128_abnormal_blood_circulation1.11054794
74MP0005166_decreased_susceptibility_to1.10917037
75MP0000733_abnormal_muscle_development1.09576360
76MP0009333_abnormal_splenocyte_physiolog1.09413972
77MP0009840_abnormal_foam_cell1.07829401
78MP0002933_joint_inflammation1.07203031
79MP0001216_abnormal_epidermal_layer1.07135766
80MP0005464_abnormal_platelet_physiology1.05939044
81MP0003448_altered_tumor_morphology1.05301865
82MP0003763_abnormal_thymus_physiology1.05200459
83MP0009764_decreased_sensitivity_to1.04390852
84MP0005623_abnormal_meninges_morphology1.04163655
85MP0004233_abnormal_muscle_weight1.04111728
86MP0003091_abnormal_cell_migration1.03866322
87MP0003941_abnormal_skin_development1.00548494
88MP0002148_abnormal_hypersensitivity_rea0.99939100
89MP0004185_abnormal_adipocyte_glucose0.99566816
90MP0002925_abnormal_cardiovascular_devel0.97937394
91MP0005275_abnormal_skin_tensile0.97559259
92MP0009785_altered_susceptibility_to0.96636112
93MP0008469_abnormal_protein_level0.96426051
94MP0000249_abnormal_blood_vessel0.96064348
95MP0004782_abnormal_surfactant_physiolog0.94084028
96MP0009278_abnormal_bone_marrow0.92794673
97MP0005164_abnormal_response_to0.90891722
98MP0002419_abnormal_innate_immunity0.90616317
99MP0002139_abnormal_hepatobiliary_system0.90578370
100MP0002877_abnormal_melanocyte_morpholog0.90481911
101MP0005023_abnormal_wound_healing0.89664068
102MP0005666_abnormal_adipose_tissue0.89459927
103MP0001614_abnormal_blood_vessel0.89062232
104MP0005310_abnormal_salivary_gland0.88945115
105MP0002060_abnormal_skin_morphology0.88416181
106MP0002006_tumorigenesis0.87494945
107MP0001853_heart_inflammation0.86901352
108MP0001790_abnormal_immune_system0.85873404
109MP0005387_immune_system_phenotype0.85873404
110MP0005025_abnormal_response_to0.85834589
111MP0000604_amyloidosis0.85267365
112MP0001542_abnormal_bone_strength0.84648747
113MP0005501_abnormal_skin_physiology0.84602357
114MP0000716_abnormal_immune_system0.84248755
115MP0001851_eye_inflammation0.84211189
116MP0005390_skeleton_phenotype0.83520369
117MP0008004_abnormal_stomach_pH0.83113946
118MP0001873_stomach_inflammation0.82965097
119MP0005000_abnormal_immune_tolerance0.82755027
120MP0001533_abnormal_skeleton_physiology0.81003167
121MP0005595_abnormal_vascular_smooth0.80487362
122MP0003045_fibrosis0.80163201
123MP0003984_embryonic_growth_retardation0.79161290
124MP0001348_abnormal_lacrimal_gland0.78845332
125MP0002088_abnormal_embryonic_growth/wei0.78701481
126MP0002452_abnormal_antigen_presenting0.78181810
127MP0001727_abnormal_embryo_implantation0.74830951
128MP0005409_darkened_coat_color0.74509346
129MP0003172_abnormal_lysosome_physiology0.73772319
130MP0003806_abnormal_nucleotide_metabolis0.73640370
131MP0005670_abnormal_white_adipose0.72874449
132MP0002429_abnormal_blood_cell0.72611449
133MP0004808_abnormal_hematopoietic_stem0.71271407
134MP0002405_respiratory_system_inflammati0.70736455
135MP0004145_abnormal_muscle_electrophysio0.66496567
136MP0002166_altered_tumor_susceptibility0.65968271
137MP0006054_spinal_hemorrhage0.65380411
138MP0001800_abnormal_humoral_immune0.63956496
139MP0002254_reproductive_system_inflammat0.63703748
140MP0005397_hematopoietic_system_phenotyp0.63036962
141MP0001545_abnormal_hematopoietic_system0.63036962
142MP0005076_abnormal_cell_differentiation0.61393631
143MP0002295_abnormal_pulmonary_circulatio0.60993307
144MP0002998_abnormal_bone_remodeling0.60529123
145MP0005375_adipose_tissue_phenotype0.60173206
146MP0000685_abnormal_immune_system0.59341117
147MP0010155_abnormal_intestine_physiology0.59273002

Predicted human phenotypes

RankGene SetZ-score
1Ventricular tachycardia (HP:0004756)6.29815382
2Sudden death (HP:0001699)6.21411246
3Muscle fiber splitting (HP:0003555)5.06917608
4Atrial fibrillation (HP:0005110)4.86595379
5Right ventricular cardiomyopathy (HP:0011663)4.84109417
6Exercise-induced muscle cramps (HP:0003710)4.60181416
7Primary atrial arrhythmia (HP:0001692)4.54972595
8Increased connective tissue (HP:0009025)4.47261749
9Lipoatrophy (HP:0100578)4.38679195
10Supraventricular arrhythmia (HP:0005115)4.37483137
11Supraventricular tachycardia (HP:0004755)4.36842442
12Hyporeflexia of lower limbs (HP:0002600)4.31669054
13Calf muscle hypertrophy (HP:0008981)4.10423086
14Asymmetric septal hypertrophy (HP:0001670)4.03038811
15Abnormality of the left ventricular outflow tract (HP:0011103)3.83212732
16Subaortic stenosis (HP:0001682)3.83212732
17Abnormality of the calf musculature (HP:0001430)3.79095654
18Hematochezia (HP:0002573)3.64648304
19EMG: myopathic abnormalities (HP:0003458)3.62807829
20Difficulty running (HP:0009046)3.58039680
21Syncope (HP:0001279)3.51922820
22Muscle hypertrophy of the lower extremities (HP:0008968)3.50913852
23Dilated cardiomyopathy (HP:0001644)3.50269563
24Exercise-induced myalgia (HP:0003738)3.16648967
25Premature rupture of membranes (HP:0001788)3.15830692
26Bundle branch block (HP:0011710)3.15509819
27Spontaneous hematomas (HP:0007420)3.10959064
28Difficulty climbing stairs (HP:0003551)3.08906975
29Ventricular arrhythmia (HP:0004308)3.08252661
30Myoglobinuria (HP:0002913)3.05676174
31Dysostosis multiplex (HP:0000943)3.02569363
32Palpitations (HP:0001962)3.01143159
33Polycythemia (HP:0001901)2.92120466
34Myocardial infarction (HP:0001658)2.86843030
35Cerebral aneurysm (HP:0004944)2.84179854
36Atrioventricular block (HP:0001678)2.82921777
37Distal lower limb muscle weakness (HP:0009053)2.77044251
38Abnormal atrioventricular conduction (HP:0005150)2.73129998
39Prolonged QT interval (HP:0001657)2.72931324
40Vertebral compression fractures (HP:0002953)2.71959831
41Heart block (HP:0012722)2.69311871
42Testicular atrophy (HP:0000029)2.69075575
43Protrusio acetabuli (HP:0003179)2.67099414
44Abnormality of the nasal mucosa (HP:0000433)2.65809050
45Loss of speech (HP:0002371)2.63868999
46Gastrointestinal stroma tumor (HP:0100723)2.58510887
47Increased cerebral lipofuscin (HP:0011813)2.55633865
48Eczematoid dermatitis (HP:0000976)2.54238571
49Recurrent abscess formation (HP:0002722)2.42226999
50Multiple enchondromatosis (HP:0005701)2.40641039
51Systemic lupus erythematosus (HP:0002725)2.38853185
52Abnormality of polysaccharide metabolism (HP:0011012)2.35573629
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35573629
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35573629
55Ventricular fibrillation (HP:0001663)2.34309738
56Thick nail (HP:0001805)2.34051705
57Increased variability in muscle fiber diameter (HP:0003557)2.32585859
58Abnormality of skeletal muscle fiber size (HP:0012084)2.31732329
59Rhabdomyolysis (HP:0003201)2.30693146
60Mucopolysacchariduria (HP:0008155)2.30419955
61Urinary glycosaminoglycan excretion (HP:0003541)2.30419955
62Tetraparesis (HP:0002273)2.29235438
63Axonal loss (HP:0003447)2.29157719
64Facial diplegia (HP:0001349)2.29107268
65Interstitial pulmonary disease (HP:0006530)2.27059191
66Myotonia (HP:0002486)2.26640077
67Mildly elevated creatine phosphokinase (HP:0008180)2.25994396
68Short nail (HP:0001799)2.25362807
69Nuclear cataract (HP:0100018)2.23161944
70Limb-girdle muscle atrophy (HP:0003797)2.21133906
71Esophageal varix (HP:0002040)2.16925033
72Pulmonary artery stenosis (HP:0004415)2.15617063
73Lymphangioma (HP:0100764)2.14267148
74IgA deficiency (HP:0002720)2.12839718
75Mediastinal lymphadenopathy (HP:0100721)2.11595738
76Aneurysm (HP:0002617)2.10581294
77Atrophic scars (HP:0001075)2.09145018
78Emphysema (HP:0002097)2.08847839
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.07987679
80Palmoplantar keratoderma (HP:0000982)2.07215554
81Amyloidosis (HP:0011034)2.05378795
82Distal lower limb amyotrophy (HP:0008944)2.03055081
83Arterial tortuosity (HP:0005116)2.02634559
84Cellulitis (HP:0100658)2.02418443
85Sudden cardiac death (HP:0001645)2.01650660
86Natal tooth (HP:0000695)2.01322767
87Cervical subluxation (HP:0003308)2.00036684
88Abnormality of the distal phalanges of the toes (HP:0010182)1.99597117
89Spinal rigidity (HP:0003306)1.98768575
90Generalized muscle weakness (HP:0003324)1.98523029
91Hemorrhage of the eye (HP:0011885)1.98068730
92Trismus (HP:0000211)1.97589079
93Areflexia of lower limbs (HP:0002522)1.97579856
94Osteolytic defects of the hand bones (HP:0009699)1.97571561
95Osteolytic defects of the phalanges of the hand (HP:0009771)1.97571561
96Scapular winging (HP:0003691)1.94104326
97Centrally nucleated skeletal muscle fibers (HP:0003687)1.93811524
98Onycholysis (HP:0001806)1.93032842
99Abnormal EKG (HP:0003115)1.91718043
100Reduced subcutaneous adipose tissue (HP:0003758)1.91305258
101Spondylolisthesis (HP:0003302)1.91212521
102Orchitis (HP:0100796)1.91167606
103Vascular tortuosity (HP:0004948)1.90640455
104Achilles tendon contracture (HP:0001771)1.89351804
105Type 1 muscle fiber predominance (HP:0003803)1.87635950
106Frequent falls (HP:0002359)1.87329926
107Bone pain (HP:0002653)1.87260644
108Pulmonary infiltrates (HP:0002113)1.86666221
109Thin bony cortex (HP:0002753)1.85533942
110Bone cyst (HP:0012062)1.84195037
111Mesangial abnormality (HP:0001966)1.84047418
112Visceral angiomatosis (HP:0100761)1.84043125
113EMG: neuropathic changes (HP:0003445)1.84038351
114Neck muscle weakness (HP:0000467)1.83470656
115Hypoplastic ischia (HP:0003175)1.83338509
116Bilateral sensorineural hearing impairment (HP:0008619)1.83241864
117Mucosal telangiectasiae (HP:0100579)1.83180397
118Glomerulonephritis (HP:0000099)1.82464061
119Upper motor neuron abnormality (HP:0002127)1.81396296
120Recurrent viral infections (HP:0004429)1.81266530
121Recurrent bacterial skin infections (HP:0005406)1.80817694
122Premature loss of primary teeth (HP:0006323)1.79564272
123Autoimmune thrombocytopenia (HP:0001973)1.78255768
124Polygenic inheritance (HP:0010982)1.78111532
125Broad metatarsal (HP:0001783)1.77633686
126Ridged nail (HP:0001807)1.77505925
127Colitis (HP:0002583)1.77436470
128Congestive heart failure (HP:0001635)1.77176119
129Broad face (HP:0000283)1.77143004
130Neurofibrillary tangles (HP:0002185)1.77003472
131Aortic aneurysm (HP:0004942)1.76720145
132Restrictive lung disease (HP:0002091)1.76252131
133Acrocyanosis (HP:0001063)1.76250864
134Hypertensive crisis (HP:0100735)1.76243465
135Neoplasm of head and neck (HP:0012288)1.76121551
136Esophageal neoplasm (HP:0100751)1.76121551
137Abnormality of glycolipid metabolism (HP:0010969)1.75726154
138Abnormality of liposaccharide metabolism (HP:0010968)1.75726154
139Abnormality of glycosphingolipid metabolism (HP:0004343)1.75726154
140Vasculitis (HP:0002633)1.75289856
141Hemangiomatosis (HP:0007461)1.74767394
142Left ventricular hypertrophy (HP:0001712)1.72876063
143Myositis (HP:0100614)1.72705701
144Dilatation of the ascending aorta (HP:0005111)1.71850904
145Conjunctival hamartoma (HP:0100780)1.71215078
146Conjunctival telangiectasia (HP:0000524)1.70919376
147Vacuolated lymphocytes (HP:0001922)1.70709296
148Ankle contracture (HP:0006466)1.69304056
149Rapidly progressive (HP:0003678)1.69198951
150Hepatosplenomegaly (HP:0001433)1.69197295
151Flat acetabular roof (HP:0003180)1.67623263
152Abnormality of the vasculature of the conjunctiva (HP:0008054)1.67471751
153Abnormality of macrophages (HP:0004311)1.66420765
154Generalized amyotrophy (HP:0003700)1.65199845
155Abnormality of the Achilles tendon (HP:0005109)1.64930293
156Hyperacusis (HP:0010780)1.64755476
157Neonatal death (HP:0003811)1.64725138
158Aortic dissection (HP:0002647)1.64277696
159Gowers sign (HP:0003391)1.64271471
160Xerostomia (HP:0000217)1.63156573
161Impaired platelet aggregation (HP:0003540)1.63136905
162Abnormal platelet function (HP:0011869)1.63136905
163Ragged-red muscle fibers (HP:0003200)1.62552764
164Joint stiffness (HP:0001387)1.62114791
165Abnormality of complement system (HP:0005339)1.61327957
166Malnutrition (HP:0004395)1.60400541
167Nephritis (HP:0000123)1.60135989
168Skin nodule (HP:0200036)1.59701424
169Apathy (HP:0000741)1.59109624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.44186425
2TIE14.05268595
3TGFBR23.88924156
4TRIB33.09758764
5ERN12.93526969
6PKN22.73984772
7PRPF4B2.71891355
8MYLK2.54001096
9DMPK2.51674483
10CDK122.16243902
11SMG12.10833366
12GRK72.07852917
13LMTK22.00253304
14KDR1.94690513
15STK101.80328564
16OBSCN1.78191016
17RIPK11.75874337
18MAP3K131.72331387
19MST1R1.69880999
20TESK11.66435535
21TAOK21.62431819
22ARAF1.53462402
23STK241.50727982
24EPHB11.50582612
25TYK21.45908084
26BLK1.44122107
27PHKG11.43564636
28PHKG21.43564636
29MAP2K31.42776104
30NEK91.36963342
31DDR21.35693057
32TBK11.34862049
33TESK21.33254107
34PAK41.31237444
35SIK11.30605717
36PDK41.30004691
37PDK31.30004691
38MAP3K31.28411972
39LRRK21.27324136
40CSF1R1.27050140
41TGFBR11.21802898
42TRPM71.19621766
43PDK21.18895482
44PTK21.16109498
45IRAK41.15369163
46KIT1.15263164
47MOS1.11812962
48CSK1.07117251
49FGFR31.04154559
50CDC42BPA1.04118548
51PRKD11.02687582
52ILK1.02263401
53MAPKAPK31.01121820
54PDGFRA0.99669243
55STK40.99246107
56LIMK10.98152377
57PRKG20.98049506
58PIK3CA0.97170495
59PTK60.93356902
60JAK10.92546986
61LATS20.91881976
62MATK0.90395943
63RIPK40.89718959
64GRK50.88977025
65ICK0.88484916
66MAP4K10.86607136
67CAMK1D0.83657839
68MAPK120.83276840
69MET0.81018276
70MAP3K10.79465598
71MAP3K80.78487005
72NME20.77421548
73MUSK0.74140490
74ZAP700.73857324
75MAP3K100.72318713
76NEK10.70954254
77ABL20.69618030
78GRK10.69396870
79MAP3K50.69324108
80FLT30.68943820
81JAK30.67563672
82RPS6KA20.67284406
83CAMK40.66676194
84WNK10.64890356
85SIK30.62920378
86MAP3K90.62701877
87FGR0.61648731
88MAPK70.60853825
89HCK0.60179099
90EPHB20.59191847
91PIM20.58838143
92FGFR40.58384736
93IKBKB0.58289916
94EPHA20.57994583
95PTK2B0.55714459
96MAP3K120.55235922
97SCYL20.53713889
98JAK20.52182368
99STK30.50847999
100PDPK10.49589182
101MARK30.49287881
102PDGFRB0.49168900
103ROCK10.48127308
104IRAK30.47935516
105BCKDK0.47850133
106PRKD20.47646953
107ITK0.47559086
108DAPK30.47332501
109GRK60.46920201
110LATS10.46839758
111PRKAA20.44924200
112CDK60.44846114
113MELK0.44610644
114TAOK10.43139779
115EEF2K0.42329819
116FES0.42108478
117MAPKAPK20.42073981
118ROCK20.41990105
119EPHA30.41947564
120ERBB40.41813405
121MAP3K70.41569199
122CHUK0.41421695
123CDK90.41142077
124MST40.40670970
125MAP3K140.40206218
126BTK0.39698627
127PAK30.39396707
128MTOR0.39331359
129BMX0.38982200
130IKBKE0.38861161
131MAPK110.38332420
132MAP3K110.38152993
133RPS6KA40.38121353
134FER0.36839941
135PAK20.35780920
136RPS6KA60.35668428
137RPS6KC10.34625885
138RPS6KL10.34625885
139IRAK10.34578870
140TEC0.34290017
141HIPK20.31433536
142LCK0.30382443

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.41541134
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.40404858
3Dilated cardiomyopathy_Homo sapiens_hsa054143.35841525
4Viral myocarditis_Homo sapiens_hsa054162.56163072
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.32844751
6Cardiac muscle contraction_Homo sapiens_hsa042602.15029757
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13232034
8Allograft rejection_Homo sapiens_hsa053302.11500374
9Leishmaniasis_Homo sapiens_hsa051401.91282070
10Autoimmune thyroid disease_Homo sapiens_hsa053201.81931557
11Graft-versus-host disease_Homo sapiens_hsa053321.79604801
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.77842905
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.76127218
14Focal adhesion_Homo sapiens_hsa045101.74204876
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73165900
16Asthma_Homo sapiens_hsa053101.67690857
17Rheumatoid arthritis_Homo sapiens_hsa053231.65442612
18Toxoplasmosis_Homo sapiens_hsa051451.64108535
19Osteoclast differentiation_Homo sapiens_hsa043801.62003041
20Other glycan degradation_Homo sapiens_hsa005111.61426208
21ECM-receptor interaction_Homo sapiens_hsa045121.61269378
22Adherens junction_Homo sapiens_hsa045201.56088498
23Lysosome_Homo sapiens_hsa041421.56005105
24Bladder cancer_Homo sapiens_hsa052191.52908864
25Staphylococcus aureus infection_Homo sapiens_hsa051501.46120810
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41069673
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39379421
28Amoebiasis_Homo sapiens_hsa051461.32113191
29Malaria_Homo sapiens_hsa051441.31625417
30Small cell lung cancer_Homo sapiens_hsa052221.30653356
31Pertussis_Homo sapiens_hsa051331.30534215
32HIF-1 signaling pathway_Homo sapiens_hsa040661.26741794
33Fatty acid degradation_Homo sapiens_hsa000711.25773627
34Platelet activation_Homo sapiens_hsa046111.20699906
35Salmonella infection_Homo sapiens_hsa051321.19256144
36Proteoglycans in cancer_Homo sapiens_hsa052051.17623437
37Prion diseases_Homo sapiens_hsa050201.17511769
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17366805
39B cell receptor signaling pathway_Homo sapiens_hsa046621.17297567
40Tuberculosis_Homo sapiens_hsa051521.16349425
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15212294
42Insulin resistance_Homo sapiens_hsa049311.15064024
43Legionellosis_Homo sapiens_hsa051341.14674073
44Type I diabetes mellitus_Homo sapiens_hsa049401.14168252
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.11317022
46Carbon metabolism_Homo sapiens_hsa012001.09771287
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09676340
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07055074
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05699079
50Apoptosis_Homo sapiens_hsa042101.04391972
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02573202
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.02506720
53Measles_Homo sapiens_hsa051621.02191464
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01143206
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99846728
56Influenza A_Homo sapiens_hsa051640.99296040
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98549594
58Antigen processing and presentation_Homo sapiens_hsa046120.92990214
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91493400
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88697711
61African trypanosomiasis_Homo sapiens_hsa051430.88527728
62Viral carcinogenesis_Homo sapiens_hsa052030.86396140
63Chronic myeloid leukemia_Homo sapiens_hsa052200.86021496
64Phagosome_Homo sapiens_hsa041450.85758670
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85579668
66Systemic lupus erythematosus_Homo sapiens_hsa053220.85166418
67Acute myeloid leukemia_Homo sapiens_hsa052210.83988344
68VEGF signaling pathway_Homo sapiens_hsa043700.82058024
69Galactose metabolism_Homo sapiens_hsa000520.81322258
70Pentose phosphate pathway_Homo sapiens_hsa000300.81285911
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.80883803
72Epstein-Barr virus infection_Homo sapiens_hsa051690.80790458
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80353095
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79323582
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79041069
76Propanoate metabolism_Homo sapiens_hsa006400.78846468
77Notch signaling pathway_Homo sapiens_hsa043300.78817934
78Shigellosis_Homo sapiens_hsa051310.76803997
79Pancreatic cancer_Homo sapiens_hsa052120.76622143
80Primary immunodeficiency_Homo sapiens_hsa053400.76179049
81Sulfur metabolism_Homo sapiens_hsa009200.75526395
82Renal cell carcinoma_Homo sapiens_hsa052110.74546216
83Parkinsons disease_Homo sapiens_hsa050120.74272497
84Herpes simplex infection_Homo sapiens_hsa051680.74103465
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73817703
86Tight junction_Homo sapiens_hsa045300.72227868
87Sphingolipid metabolism_Homo sapiens_hsa006000.71656123
88Vibrio cholerae infection_Homo sapiens_hsa051100.71006357
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69931416
90TNF signaling pathway_Homo sapiens_hsa046680.69720635
91Hematopoietic cell lineage_Homo sapiens_hsa046400.68727424
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68587153
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66538737
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65677714
95MicroRNAs in cancer_Homo sapiens_hsa052060.64455741
96T cell receptor signaling pathway_Homo sapiens_hsa046600.64316207
97mTOR signaling pathway_Homo sapiens_hsa041500.64243237
98Caffeine metabolism_Homo sapiens_hsa002320.64140459
99Dorso-ventral axis formation_Homo sapiens_hsa043200.63239564
100Fatty acid metabolism_Homo sapiens_hsa012120.62523555
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62016205
102Complement and coagulation cascades_Homo sapiens_hsa046100.60006077
103Pathways in cancer_Homo sapiens_hsa052000.58590070
104Insulin signaling pathway_Homo sapiens_hsa049100.57356005
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.57235391
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.56686458
107Chemokine signaling pathway_Homo sapiens_hsa040620.56436386
108Rap1 signaling pathway_Homo sapiens_hsa040150.56217113
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56058709
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55322298
111Prolactin signaling pathway_Homo sapiens_hsa049170.54873130
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.54731922
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53890323
114Hepatitis B_Homo sapiens_hsa051610.52903020
115Thyroid cancer_Homo sapiens_hsa052160.52895480
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52634681
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51872182
118AMPK signaling pathway_Homo sapiens_hsa041520.50946847
119* Endocytosis_Homo sapiens_hsa041440.50698895
120Fructose and mannose metabolism_Homo sapiens_hsa000510.50533798
121Hepatitis C_Homo sapiens_hsa051600.49915685
122Alzheimers disease_Homo sapiens_hsa050100.49352986
123Renin-angiotensin system_Homo sapiens_hsa046140.49090189
124HTLV-I infection_Homo sapiens_hsa051660.48201250
125PPAR signaling pathway_Homo sapiens_hsa033200.47736153
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.47021148
127Prostate cancer_Homo sapiens_hsa052150.46865717
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.46147163
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45802942
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45777568

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