EGFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1coronary vasculature morphogenesis (GO:0060977)7.37587381
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.21182815
3L-phenylalanine catabolic process (GO:0006559)7.21182815
4positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003607.14139221
5regulation of endothelial cell chemotaxis (GO:2001026)6.89568932
6L-phenylalanine metabolic process (GO:0006558)6.84255085
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.84255085
8surfactant homeostasis (GO:0043129)6.83942968
9aromatic amino acid family catabolic process (GO:0009074)6.64606035
10endothelial cell chemotaxis (GO:0035767)6.57197880
11venous blood vessel morphogenesis (GO:0048845)6.53926880
12positive regulation of p38MAPK cascade (GO:1900745)6.48236777
13indole-containing compound catabolic process (GO:0042436)6.25932838
14indolalkylamine catabolic process (GO:0046218)6.25932838
15tryptophan catabolic process (GO:0006569)6.25932838
16hemidesmosome assembly (GO:0031581)6.25594402
17regulation of protein activation cascade (GO:2000257)6.07240412
18complement activation, alternative pathway (GO:0006957)6.05334267
19bile acid biosynthetic process (GO:0006699)6.02600538
20kynurenine metabolic process (GO:0070189)6.01059117
21tryptophan metabolic process (GO:0006568)5.86398691
22regulation of complement activation (GO:0030449)5.75773560
23urea metabolic process (GO:0019627)5.71272822
24urea cycle (GO:0000050)5.71272822
25glyoxylate metabolic process (GO:0046487)5.58638738
26regulation of axon extension involved in axon guidance (GO:0048841)5.54956568
27negative regulation of fibrinolysis (GO:0051918)5.54259854
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.51360173
29regulation of fibrinolysis (GO:0051917)5.48560149
30alpha-linolenic acid metabolic process (GO:0036109)5.45682303
31chemical homeostasis within a tissue (GO:0048875)5.40932462
32peptidyl-glutamic acid carboxylation (GO:0017187)5.38184201
33protein carboxylation (GO:0018214)5.38184201
34lung vasculature development (GO:0060426)5.30740225
35nitrogen cycle metabolic process (GO:0071941)5.21101289
36cysteine metabolic process (GO:0006534)5.16060370
37sulfur amino acid catabolic process (GO:0000098)5.11524318
38glucosamine-containing compound catabolic process (GO:1901072)5.10070836
39homocysteine metabolic process (GO:0050667)5.01664135
40bile acid metabolic process (GO:0008206)4.98116137
41regulation of p38MAPK cascade (GO:1900744)4.92768149
42high-density lipoprotein particle remodeling (GO:0034375)4.91622176
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88017334
44positive regulation of vascular permeability (GO:0043117)4.87877985
45vascular endothelial growth factor signaling pathway (GO:0038084)4.82380086
46dermatan sulfate biosynthetic process (GO:0030208)4.77144904
47aromatic amino acid family metabolic process (GO:0009072)4.76365148
48serine family amino acid catabolic process (GO:0009071)4.75877670
49regulation of axon guidance (GO:1902667)4.70160536
50cell adhesion mediated by integrin (GO:0033627)4.66414419
51positive regulation of protein kinase C signaling (GO:0090037)4.65095880
52dermatan sulfate metabolic process (GO:0030205)4.62205301
53astrocyte differentiation (GO:0048708)4.61085013
54coenzyme catabolic process (GO:0009109)4.60781954
55regulation of triglyceride catabolic process (GO:0010896)4.57843586
56positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)4.54546042
57tyrosine metabolic process (GO:0006570)4.53353291
58reverse cholesterol transport (GO:0043691)4.44819986
59alpha-amino acid catabolic process (GO:1901606)4.43543264
60lysine metabolic process (GO:0006553)4.43256682
61lysine catabolic process (GO:0006554)4.43256682
62triglyceride homeostasis (GO:0070328)4.40382329
63acylglycerol homeostasis (GO:0055090)4.40382329
64indolalkylamine metabolic process (GO:0006586)4.39108621
65plasma lipoprotein particle remodeling (GO:0034369)4.34581566
66protein-lipid complex remodeling (GO:0034368)4.34581566
67macromolecular complex remodeling (GO:0034367)4.34581566
68amine catabolic process (GO:0009310)4.31044599
69cellular biogenic amine catabolic process (GO:0042402)4.31044599
70bile acid and bile salt transport (GO:0015721)4.28788292
71amino-acid betaine metabolic process (GO:0006577)4.28125732
72cytolysis (GO:0019835)4.25417627
73fibrinolysis (GO:0042730)4.21966694
74cellular glucuronidation (GO:0052695)4.20477376
75cellular modified amino acid catabolic process (GO:0042219)4.19164553
76glutamate metabolic process (GO:0006536)4.16049212
77imidazole-containing compound metabolic process (GO:0052803)4.14648130
78desmosome organization (GO:0002934)4.13865014
79regulation of cholesterol esterification (GO:0010872)4.13798898
80complement activation, classical pathway (GO:0006958)4.11303440
81phospholipid efflux (GO:0033700)4.08409493
82cellular amino acid catabolic process (GO:0009063)4.07112967
83negative regulation of protein activation cascade (GO:2000258)4.05210303
84complement activation (GO:0006956)4.02784517
85ethanol oxidation (GO:0006069)3.99337715
86dicarboxylic acid biosynthetic process (GO:0043650)3.99094232
87glycine metabolic process (GO:0006544)3.98777462
88regulation of bile acid biosynthetic process (GO:0070857)3.97890481
89plasma lipoprotein particle clearance (GO:0034381)3.95523146
90benzene-containing compound metabolic process (GO:0042537)3.94166114
91astrocyte development (GO:0014002)3.93914347
92camera-type eye morphogenesis (GO:0048593)3.93881010
93protein activation cascade (GO:0072376)3.91434071
94serine family amino acid metabolic process (GO:0009069)3.88753922
95negative regulation of cholesterol transport (GO:0032375)3.88618863
96negative regulation of sterol transport (GO:0032372)3.88618863
97positive regulation of axon extension (GO:0045773)3.86763316
98cholesterol efflux (GO:0033344)3.84511104
99cellular ketone body metabolic process (GO:0046950)3.84153183
100cell migration involved in sprouting angiogenesis (GO:0002042)3.83515413
101regulation of cholesterol homeostasis (GO:2000188)3.80276657
102arginine metabolic process (GO:0006525)3.78374021
103acetyl-CoA metabolic process (GO:0006084)3.76534446
104chondroitin sulfate catabolic process (GO:0030207)3.73728263
105regulation of plasminogen activation (GO:0010755)3.72518159
106glucuronate metabolic process (GO:0019585)3.71510522
107uronic acid metabolic process (GO:0006063)3.71510522
108regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.71001030
109blood coagulation, intrinsic pathway (GO:0007597)3.68666777
110phospholipid homeostasis (GO:0055091)3.68311718
111cell-substrate junction assembly (GO:0007044)3.67462052
112plasma lipoprotein particle assembly (GO:0034377)3.66600333
113cofactor catabolic process (GO:0051187)3.66393548
114very-low-density lipoprotein particle assembly (GO:0034379)3.65671444
115low-density lipoprotein particle remodeling (GO:0034374)3.64613767
116serine family amino acid biosynthetic process (GO:0009070)3.62563586
117positive regulation of fatty acid beta-oxidation (GO:0032000)3.61065460
118opsonization (GO:0008228)3.58978848
119negative regulation of lipase activity (GO:0060192)3.57037694
120regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.55665671
121positive regulation of lipid catabolic process (GO:0050996)3.54136192
122cholesterol homeostasis (GO:0042632)3.53017772
123induction of positive chemotaxis (GO:0050930)3.52952433
124aldehyde catabolic process (GO:0046185)3.52596974
125positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.51475133
126epoxygenase P450 pathway (GO:0019373)3.51436207
127acute-phase response (GO:0006953)3.51238903
128positive regulation of blood vessel endothelial cell migration (GO:0043536)3.50692819
129organic acid catabolic process (GO:0016054)3.49027519
130carboxylic acid catabolic process (GO:0046395)3.49027519
131regulation of mitotic spindle organization (GO:0060236)3.47636375
132sterol homeostasis (GO:0055092)3.47580716
133response to nitrosative stress (GO:0051409)3.41178939
134positive regulation of histone deacetylation (GO:0031065)3.40805520
135lipoprotein metabolic process (GO:0042157)3.37632583
136drug catabolic process (GO:0042737)3.37323162
137insulin-like growth factor receptor signaling pathway (GO:0048009)3.36081877
138positive regulation of neuroblast proliferation (GO:0002052)3.35811241
139mammary gland alveolus development (GO:0060749)3.33746936
140cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.31166174
141dopaminergic neuron differentiation (GO:0071542)3.28916089
142vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.24305995
143postsynaptic membrane organization (GO:0001941)3.19579483
144positive regulation of adherens junction organization (GO:1903393)3.18286640
145Notch signaling involved in heart development (GO:0061314)3.17831520
146chondroitin sulfate biosynthetic process (GO:0030206)3.15599802
147negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11882473
148regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.09710571
149regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.07753269
150regulation of transforming growth factor beta2 production (GO:0032909)3.05634724
151positive regulation of cell junction assembly (GO:1901890)3.04768227
152positive regulation of focal adhesion assembly (GO:0051894)3.04768227
153positive regulation of positive chemotaxis (GO:0050927)2.97636052
154T-helper 1 type immune response (GO:0042088)2.96923053
155retina vasculature morphogenesis in camera-type eye (GO:0061299)2.95580138
156skin morphogenesis (GO:0043589)2.94999619
157endocardial cushion morphogenesis (GO:0003203)2.94324663
158semaphorin-plexin signaling pathway (GO:0071526)2.92677980
159maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90328080
160monocyte differentiation (GO:0030224)2.88629970
161activation of NF-kappaB-inducing kinase activity (GO:0007250)2.85548767
162negative regulation of bone resorption (GO:0045779)2.84258654
163regulation of neuroblast proliferation (GO:1902692)2.81994583
164regulation of positive chemotaxis (GO:0050926)2.81014744
165hyperosmotic salinity response (GO:0042538)2.80234585
166positive regulation of CREB transcription factor activity (GO:0032793)2.79580070
167sprouting angiogenesis (GO:0002040)2.79162422
168positive regulation of mesonephros development (GO:0061213)2.78876584
169amino sugar catabolic process (GO:0046348)2.74291901
170positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.73887614
171regulation of protein kinase C signaling (GO:0090036)2.73850478
172negative regulation of chondrocyte differentiation (GO:0032331)2.71183620
173protein retention in ER lumen (GO:0006621)2.67692113
174blood vessel endothelial cell migration (GO:0043534)2.65778118
175mesodermal cell differentiation (GO:0048333)2.64250853
176heart valve formation (GO:0003188)2.63526108
177protein localization to endosome (GO:0036010)2.62394251
178platelet-derived growth factor receptor signaling pathway (GO:0048008)2.62259568
179cell-substrate adherens junction assembly (GO:0007045)2.59776625
180focal adhesion assembly (GO:0048041)2.59776625
181positive regulation of protein autophosphorylation (GO:0031954)2.56575164
182neuron projection regeneration (GO:0031102)2.52891977
183regulation of extracellular matrix organization (GO:1903053)2.52126775
184regulation of mesonephros development (GO:0061217)2.52017112
185positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.50580999
186membrane assembly (GO:0071709)2.47290174
187dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47047338
188positive regulation of osteoblast proliferation (GO:0033690)2.44619599
189positive regulation of astrocyte differentiation (GO:0048711)2.43812296
190negative regulation of bone remodeling (GO:0046851)2.43380317
191negative regulation of fatty acid transport (GO:2000192)2.41854199
192adherens junction assembly (GO:0034333)2.41689983
193mesenchyme morphogenesis (GO:0072132)2.41633459
194planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41554056
195one-carbon compound transport (GO:0019755)2.41395132
196regulation of glucose import in response to insulin stimulus (GO:2001273)2.40297584
197keratinocyte proliferation (GO:0043616)2.38708907
198negative regulation of tissue remodeling (GO:0034104)2.37916552
199atrioventricular valve morphogenesis (GO:0003181)2.37771465
200hypotonic response (GO:0006971)2.36782248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.46897817
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.46644947
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.37123923
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.94461356
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.05976946
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.73445032
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.19452814
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.11540798
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99471771
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.18545039
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.85726924
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76241874
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43219694
14* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24150533
15* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.13792045
16* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.13792045
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.08896717
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.03230330
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6969732
20* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85764890
21CLOCK_20551151_ChIP-Seq_293T_Human1.82921369
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82663430
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81964330
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75049888
25* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72862200
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71374349
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.69111123
28* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.66654866
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64521894
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64261425
31AR_21909140_ChIP-Seq_LNCAP_Human1.63362466
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.60243890
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59099844
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57436170
35NFIB_24661679_ChIP-Seq_LUNG_Mouse1.56396704
36ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55108162
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51914345
38JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51137510
39HTT_18923047_ChIP-ChIP_STHdh_Human1.49924399
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47884613
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.47440086
42ATF3_27146783_Chip-Seq_COLON_Human1.46133865
43* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44952142
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.43850607
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.43850607
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37910986
47* BRD4_25478319_ChIP-Seq_HGPS_Human1.37883777
48UBF1/2_26484160_Chip-Seq_HMECs_Human1.35124732
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34845215
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34704200
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.34536585
52GATA1_22025678_ChIP-Seq_K562_Human1.33337447
53* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30344069
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26713530
55* TP53_23651856_ChIP-Seq_MEFs_Mouse1.26668651
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26586267
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25126787
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24815006
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23478938
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22505926
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17947705
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17865478
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17865478
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.17277740
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.14608227
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13577612
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12219753
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12111346
69KDM2B_26808549_Chip-Seq_K562_Human1.10101512
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09104952
71NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08062297
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07765580
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07765580
74* AHR_22903824_ChIP-Seq_MCF-7_Human1.07408783
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.07253882
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07095431
77* ARNT_22903824_ChIP-Seq_MCF-7_Human1.06801469
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.06154618
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05189576
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05052684
81LXR_22292898_ChIP-Seq_THP-1_Human1.04915376
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02153529
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01790044
84RACK7_27058665_Chip-Seq_MCF-7_Human0.99833929
85SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99653148
86* KLF5_25053715_ChIP-Seq_YYC3_Human0.97289461
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95955021
88TP53_22127205_ChIP-Seq_IMR90_Human0.95699144
89YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94456164
90RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94199881
91* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94186370
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93908157
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.91958630
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91756832
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.91284636
96GATA4_25053715_ChIP-Seq_YYC3_Human0.90950183
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90904912
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.90668000
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90247857
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88354682
101* TP63_22573176_ChIP-Seq_HFKS_Human0.88205125
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87251251
103* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86357218
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85034823
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.84982221
106* EED_16625203_ChIP-ChIP_MESCs_Mouse0.83113805
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83111907
108* RNF2_27304074_Chip-Seq_ESCs_Mouse0.82380614
109* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82356602
110RUNX1_27514584_Chip-Seq_MCF-7_Human0.82158706
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82118642
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82105856
113* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81394248
114BCAT_22108803_ChIP-Seq_LS180_Human0.80941075
115AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80830522
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80468722
117* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74988943
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.74468119
119* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71383520
120* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.69961546
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68546699
122* SOX2_20726797_ChIP-Seq_SW620_Human0.67854100
123TAF15_26573619_Chip-Seq_HEK293_Human0.67663384
124* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.66480376
125* CJUN_26792858_Chip-Seq_BT549_Human0.65505980
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.63401016
127TP53_18474530_ChIP-ChIP_U2OS_Human0.62751579
128* TP63_23658742_ChIP-Seq_EP156T_Human0.61904304
129* CDX2_20551321_ChIP-Seq_CACO-2_Human0.60612840
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60500633
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.60278926
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.58333861
133KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57350302
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57068877
135PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.56886364
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.56203588
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55901934
138* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54026623
139CBP_21632823_ChIP-Seq_H3396_Human0.52838433
140ZNF263_19887448_ChIP-Seq_K562_Human0.51814905
141* CDX2_22108803_ChIP-Seq_LS180_Human0.51511037
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51508705
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.50832708
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.50593434
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.50247276
146SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.50078097
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.49343371
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.49254306
149* AR_20517297_ChIP-Seq_VCAP_Human0.47349571
150* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.46720127
151TP53_16413492_ChIP-PET_HCT116_Human0.45755003
152RARA_24833708_ChIP-Seq_LIVER_Mouse0.45628286
153CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.45181117
154STAT1_17558387_ChIP-Seq_HELA_Human0.45000593
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.44677056
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.44633663
157SUZ12_27294783_Chip-Seq_NPCs_Mouse0.44606925
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44603492
159* CEBPB_22108803_ChIP-Seq_LS180_Human0.44587217
160MYC_19915707_ChIP-ChIP_AK7_Human0.43572855
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.43513519
162GATA6_25053715_ChIP-Seq_YYC3_Human0.43246825
163* CRX_20693478_ChIP-Seq_RETINA_Mouse0.43063431
164* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.43051712
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.42480316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.83615667
2MP0005360_urolithiasis7.35043139
3MP0005085_abnormal_gallbladder_physiolo6.40871077
4MP0005365_abnormal_bile_salt6.00239639
5MP0008875_abnormal_xenobiotic_pharmacok4.53439408
6MP0003252_abnormal_bile_duct4.22748887
7MP0003806_abnormal_nucleotide_metabolis3.64076097
8MP0010329_abnormal_lipoprotein_level3.39523762
9MP0000678_abnormal_parathyroid_gland2.98833427
10MP0005083_abnormal_biliary_tract2.97199417
11MP0003566_abnormal_cell_adhesion2.77213588
12MP0004084_abnormal_cardiac_muscle2.67479946
13MP0003195_calcinosis2.61751082
14MP0009840_abnormal_foam_cell2.59525789
15MP0001666_abnormal_nutrient_absorption2.54550153
16* MP0005332_abnormal_amino_acid2.49569671
17MP0001879_abnormal_lymphatic_vessel2.49480562
18MP0004233_abnormal_muscle_weight2.49282971
19MP0001849_ear_inflammation2.29699061
20MP0003950_abnormal_plasma_membrane2.29366545
21* MP0000762_abnormal_tongue_morphology2.19436989
22MP0005257_abnormal_intraocular_pressure2.16680476
23MP0002877_abnormal_melanocyte_morpholog2.15348559
24MP0003191_abnormal_cellular_cholesterol2.14019306
25MP0002254_reproductive_system_inflammat2.10398674
26MP0004019_abnormal_vitamin_homeostasis2.09396602
27MP0002138_abnormal_hepatobiliary_system2.01664262
28* MP0000609_abnormal_liver_physiology2.01605068
29MP0003705_abnormal_hypodermis_morpholog2.01197115
30MP0003868_abnormal_feces_composition2.00213692
31MP0002118_abnormal_lipid_homeostasis1.98956521
32MP0009780_abnormal_chondrocyte_physiolo1.95065114
33* MP0000467_abnormal_esophagus_morphology1.78691128
34* MP0003091_abnormal_cell_migration1.75519252
35MP0004858_abnormal_nervous_system1.75329063
36MP0001958_emphysema1.68658345
37MP0005319_abnormal_enzyme/_coenzyme1.66364530
38MP0005409_darkened_coat_color1.65663550
39MP0003941_abnormal_skin_development1.62737774
40MP0003011_delayed_dark_adaptation1.61791669
41MP0002896_abnormal_bone_mineralization1.60134251
42MP0004036_abnormal_muscle_relaxation1.55448181
43MP0000747_muscle_weakness1.54418889
44MP0003634_abnormal_glial_cell1.46044807
45MP0003123_paternal_imprinting1.45753917
46MP0005076_abnormal_cell_differentiation1.45660044
47MP0010352_gastrointestinal_tract_polyps1.44793588
48MP0001348_abnormal_lacrimal_gland1.43531547
49MP0005647_abnormal_sex_gland1.35672936
50MP0002234_abnormal_pharynx_morphology1.34876177
51MP0009697_abnormal_copulation1.33351933
52MP0005584_abnormal_enzyme/coenzyme_acti1.32685048
53MP0001764_abnormal_homeostasis1.30277519
54* MP0008775_abnormal_heart_ventricle1.29130706
55MP0004782_abnormal_surfactant_physiolog1.26121591
56MP0000534_abnormal_ureter_morphology1.20974641
57MP0010368_abnormal_lymphatic_system1.19588537
58MP0008438_abnormal_cutaneous_collagen1.19053861
59MP0000751_myopathy1.18692500
60MP0002269_muscular_atrophy1.16653586
61MP0005451_abnormal_body_composition1.15596721
62MP0000733_abnormal_muscle_development1.14565134
63MP0005623_abnormal_meninges_morphology1.13858501
64* MP0000383_abnormal_hair_follicle1.13630765
65MP0005275_abnormal_skin_tensile1.11884937
66MP0009643_abnormal_urine_homeostasis1.10664069
67* MP0010678_abnormal_skin_adnexa1.07386238
68MP0000537_abnormal_urethra_morphology1.06481583
69MP0009053_abnormal_anal_canal1.06327131
70* MP0000598_abnormal_liver_morphology1.06227869
71MP0009764_decreased_sensitivity_to1.05293056
72* MP0003755_abnormal_palate_morphology1.04574330
73MP0005670_abnormal_white_adipose1.02969121
74MP0002796_impaired_skin_barrier1.02907336
75MP0001915_intracranial_hemorrhage1.01679739
76MP0001853_heart_inflammation1.00945585
77MP0003279_aneurysm0.99464898
78* MP0010771_integument_phenotype0.98947673
79* MP0000432_abnormal_head_morphology0.98619692
80MP0003186_abnormal_redox_activity0.97901718
81MP0001299_abnormal_eye_distance/0.97484572
82MP0004185_abnormal_adipocyte_glucose0.96508659
83MP0001984_abnormal_olfaction0.95495388
84MP0004381_abnormal_hair_follicle0.94740751
85* MP0003115_abnormal_respiratory_system0.94566269
86MP0005084_abnormal_gallbladder_morpholo0.93562997
87* MP0009763_increased_sensitivity_to0.90489016
88MP0000749_muscle_degeneration0.90065026
89MP0000003_abnormal_adipose_tissue0.89204131
90MP0001502_abnormal_circadian_rhythm0.88792010
91* MP0003935_abnormal_craniofacial_develop0.87874707
92MP0003937_abnormal_limbs/digits/tail_de0.87106876
93MP0000604_amyloidosis0.84744090
94MP0005375_adipose_tissue_phenotype0.84436941
95MP0000428_abnormal_craniofacial_morphol0.84341797
96* MP0002060_abnormal_skin_morphology0.83671633
97MP0005408_hypopigmentation0.81895007
98MP0010234_abnormal_vibrissa_follicle0.81545117
99MP0002876_abnormal_thyroid_physiology0.80622266
100MP0003656_abnormal_erythrocyte_physiolo0.79465577
101MP0000627_abnormal_mammary_gland0.78769452
102MP0005636_abnormal_mineral_homeostasis0.77314613
103MP0000767_abnormal_smooth_muscle0.77272523
104MP0002971_abnormal_brown_adipose0.76104972
105MP0002928_abnormal_bile_duct0.75607402
106MP0004087_abnormal_muscle_fiber0.75398218
107MP0003385_abnormal_body_wall0.74598306
108MP0002089_abnormal_postnatal_growth/wei0.73150645
109MP0001661_extended_life_span0.73044345
110* MP0009642_abnormal_blood_homeostasis0.73035940
111MP0004130_abnormal_muscle_cell0.72898730
112MP0010030_abnormal_orbit_morphology0.71848845
113MP0002909_abnormal_adrenal_gland0.71777055
114* MP0002116_abnormal_craniofacial_bone0.71683920
115MP0000778_abnormal_nervous_system0.71238231
116* MP0001340_abnormal_eyelid_morphology0.71115672
117MP0009250_abnormal_appendicular_skeleto0.70652896
118* MP0005220_abnormal_exocrine_pancreas0.70011424
119MP0000566_synostosis0.69651783
120MP0003283_abnormal_digestive_organ0.69283437
121MP0004947_skin_inflammation0.68727354
122* MP0008469_abnormal_protein_level0.68697705
123MP0000920_abnormal_myelination0.68436336
124* MP0001177_atelectasis0.68250982
125MP0003453_abnormal_keratinocyte_physiol0.66667749
126MP0005376_homeostasis/metabolism_phenot0.66314580
127MP0005334_abnormal_fat_pad0.66268479
128MP0009765_abnormal_xenobiotic_induced0.66033491
129* MP0005197_abnormal_uvea_morphology0.66027796
130MP0003959_abnormal_lean_body0.64297472
131MP0003690_abnormal_glial_cell0.64282250
132MP0002078_abnormal_glucose_homeostasis0.63288402
133MP0005248_abnormal_Harderian_gland0.62355776
134MP0000647_abnormal_sebaceous_gland0.59014374
135MP0001243_abnormal_dermal_layer0.58868473
136* MP0000579_abnormal_nail_morphology0.58466137
137MP0005666_abnormal_adipose_tissue0.58383164
138MP0005395_other_phenotype0.58020861
139MP0002168_other_aberrant_phenotype0.56678503
140MP0005535_abnormal_body_temperature0.51627693
141MP0002295_abnormal_pulmonary_circulatio0.51311347
142MP0001756_abnormal_urination0.51269860
143* MP0009384_cardiac_valve_regurgitation0.49883392
144MP0005023_abnormal_wound_healing0.49833176
145MP0000639_abnormal_adrenal_gland0.49056986
146MP0005503_abnormal_tendon_morphology0.45744248
147MP0002136_abnormal_kidney_physiology0.44667448
148MP0005501_abnormal_skin_physiology0.44368476
149MP0005448_abnormal_energy_balance0.43975790
150MP0003300_gastrointestinal_ulcer0.42950670
151MP0002249_abnormal_larynx_morphology0.42328692
152MP0003329_amyloid_beta_deposits0.42147098
153MP0005266_abnormal_metabolism0.41920951
154MP0005166_decreased_susceptibility_to0.41611689
155MP0000538_abnormal_urinary_bladder0.41479889
156* MP0000427_abnormal_hair_cycle0.40474353
157MP0005164_abnormal_response_to0.40368729
158* MP0000377_abnormal_hair_follicle0.39720988
159MP0003724_increased_susceptibility_to0.39035624
160MP0004883_abnormal_blood_vessel0.38973388
161MP0003638_abnormal_response/metabolism_0.37974793
162MP0002282_abnormal_trachea_morphology0.37606078
163MP0005595_abnormal_vascular_smooth0.37460851
164MP0009115_abnormal_fat_cell0.37433654
165* MP0001216_abnormal_epidermal_layer0.37238749
166MP0004264_abnormal_extraembryonic_tissu0.36523806
167MP0004272_abnormal_basement_membrane0.35391872
168MP0003075_altered_response_to0.33416320
169MP0003953_abnormal_hormone_level0.31133061
170* MP0002098_abnormal_vibrissa_morphology0.30605519

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.70806247
2Deep venous thrombosis (HP:0002625)7.38611268
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.88625444
4Complement deficiency (HP:0004431)6.68738672
5Prolonged partial thromboplastin time (HP:0003645)6.65689740
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.60852661
7Xanthomatosis (HP:0000991)6.35502866
8Hypobetalipoproteinemia (HP:0003563)6.01013275
9Hyperlipoproteinemia (HP:0010980)5.19801398
10Epidermoid cyst (HP:0200040)4.98639122
11Abnormality of complement system (HP:0005339)4.89898583
12Hyperacusis (HP:0010780)4.80650807
13Hypolipoproteinemia (HP:0010981)4.75738092
14Abnormality of the common coagulation pathway (HP:0010990)4.74711574
15Joint hemorrhage (HP:0005261)4.70133815
16Hypoalphalipoproteinemia (HP:0003233)4.38902859
17Fat malabsorption (HP:0002630)4.35682923
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.31173485
19Hyperammonemia (HP:0001987)4.27619268
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.22706242
21Hyperglycinemia (HP:0002154)4.21978716
22Atrophic scars (HP:0001075)4.10183453
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.05545273
24Abnormality of methionine metabolism (HP:0010901)3.99594388
25Ketosis (HP:0001946)3.97016543
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.93769499
27Abnormality of the intrinsic pathway (HP:0010989)3.92694335
28Neurofibrillary tangles (HP:0002185)3.91893093
29Conjugated hyperbilirubinemia (HP:0002908)3.88992733
30Elfin facies (HP:0004428)3.86034415
31Abnormality of glycine metabolism (HP:0010895)3.68881260
32Abnormality of serine family amino acid metabolism (HP:0010894)3.68881260
33Insomnia (HP:0100785)3.67091574
34Hyperglycinuria (HP:0003108)3.66738201
35Hypoglycemic coma (HP:0001325)3.55847396
36Cerebral inclusion bodies (HP:0100314)3.50280435
37Abnormality of pyrimidine metabolism (HP:0004353)3.48727874
38Overriding aorta (HP:0002623)3.48399981
39Myocardial infarction (HP:0001658)3.47874433
40Milia (HP:0001056)3.47715032
41Spontaneous abortion (HP:0005268)3.44155564
42Hypercholesterolemia (HP:0003124)3.39389081
43Bladder diverticulum (HP:0000015)3.33380468
44Renovascular hypertension (HP:0100817)3.26916554
45Shallow orbits (HP:0000586)3.26666612
46Steatorrhea (HP:0002570)3.24595972
47Protrusio acetabuli (HP:0003179)3.23819518
48Abnormality of the diencephalon (HP:0010662)3.17486194
49Renal duplication (HP:0000075)3.15684875
50Flat cornea (HP:0007720)3.13810697
51Split foot (HP:0001839)3.11795606
52Skin nodule (HP:0200036)3.10125788
53Obstructive sleep apnea (HP:0002870)3.08468825
54Systemic lupus erythematosus (HP:0002725)3.06470922
55Hepatocellular carcinoma (HP:0001402)3.05812400
56Selective tooth agenesis (HP:0001592)3.03957188
57Premature rupture of membranes (HP:0001788)3.00537204
58Natal tooth (HP:0000695)2.96983002
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.96317880
60Arterial tortuosity (HP:0005116)2.94312058
61Onycholysis (HP:0001806)2.94221140
62Hyperbilirubinemia (HP:0002904)2.91355790
63Fragile skin (HP:0001030)2.91347447
64Abnormality of fatty-acid metabolism (HP:0004359)2.88121324
65Abnormality of nucleobase metabolism (HP:0010932)2.86118734
66Hypochromic microcytic anemia (HP:0004840)2.85458006
67Fragile nails (HP:0001808)2.84870491
68Abnormality of serum amino acid levels (HP:0003112)2.84798737
69Spinal rigidity (HP:0003306)2.84436723
70Ketoacidosis (HP:0001993)2.80537689
71Vertebral compression fractures (HP:0002953)2.79882547
72Recurrent gram-negative bacterial infections (HP:0005420)2.74708887
73Mitral stenosis (HP:0001718)2.73936356
74Thick nail (HP:0001805)2.73915440
75Vascular tortuosity (HP:0004948)2.70222763
76Advanced eruption of teeth (HP:0006288)2.67870885
77Delayed CNS myelination (HP:0002188)2.67393798
78Vascular calcification (HP:0004934)2.64812495
79Acanthocytosis (HP:0001927)2.60326663
80Cardiovascular calcification (HP:0011915)2.58320455
81Short nail (HP:0001799)2.57931790
82Vertebral arch anomaly (HP:0008438)2.55779011
83Abnormality of purine metabolism (HP:0004352)2.54814164
84Spastic diplegia (HP:0001264)2.53487421
85Ankyloglossia (HP:0010296)2.53081011
86Cervical subluxation (HP:0003308)2.50676278
87Nail dystrophy (HP:0008404)2.49026772
88Broad face (HP:0000283)2.48465465
89Amyloidosis (HP:0011034)2.46371053
90Plantar hyperkeratosis (HP:0007556)2.46299220
91Arnold-Chiari malformation (HP:0002308)2.45330758
92Abnormality of nail color (HP:0100643)2.44812332
93Ankle contracture (HP:0006466)2.43026062
94Bowel diverticulosis (HP:0005222)2.39690786
95Hypoglycemic seizures (HP:0002173)2.38231674
96Esophageal varix (HP:0002040)2.37829078
97Osteolytic defects of the phalanges of the hand (HP:0009771)2.36809542
98Osteolytic defects of the hand bones (HP:0009699)2.36809542
99Missing ribs (HP:0000921)2.35049488
100Gingival bleeding (HP:0000225)2.34969328
101Metabolic acidosis (HP:0001942)2.34353519
102Gout (HP:0001997)2.33884826
103Neonatal onset (HP:0003623)2.30668937
104Abnormal gallbladder morphology (HP:0012437)2.25782472
105Mitral regurgitation (HP:0001653)2.25083802
106Enlarged kidneys (HP:0000105)2.24568920
107Glomerulonephritis (HP:0000099)2.24493487
108Lethargy (HP:0001254)2.20711302
109Cholelithiasis (HP:0001081)2.18799205
110Cerebral aneurysm (HP:0004944)2.18751095
111Megalocornea (HP:0000485)2.18525533
112Nuclear cataract (HP:0100018)2.13915484
113Sensorimotor neuropathy (HP:0007141)2.13718168
114Abnormality of oral frenula (HP:0000190)2.13323173
115Hemorrhage of the eye (HP:0011885)2.07304167
116Overgrowth (HP:0001548)2.07126641
117Irritability (HP:0000737)2.05617693
118Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05515846
119Dicarboxylic aciduria (HP:0003215)2.05515846
120Malnutrition (HP:0004395)2.05080968
121Rickets (HP:0002748)2.04143678
122Urethral obstruction (HP:0000796)2.04089424
123Aplasia cutis congenita (HP:0001057)2.03058521
124Alopecia of scalp (HP:0002293)2.02360177
125Hypophosphatemic rickets (HP:0004912)2.02355354
126Thrombophlebitis (HP:0004418)2.02095087
127Cholecystitis (HP:0001082)2.01906345
128Abnormal gallbladder physiology (HP:0012438)2.01906345
129Menorrhagia (HP:0000132)2.01084930
130Laryngomalacia (HP:0001601)2.00941635
131Hallux valgus (HP:0001822)1.99925919
132Hyperglycemia (HP:0003074)1.98503808
133Wormian bones (HP:0002645)1.96858146
134Pancreatitis (HP:0001733)1.96615144
135Aplasia involving bones of the extremities (HP:0009825)1.96452604
136Aplasia involving bones of the upper limbs (HP:0009823)1.96452604
137Aplasia of the phalanges of the hand (HP:0009802)1.96452604
138Hydroxyprolinuria (HP:0003080)1.95486699
139Abnormality of proline metabolism (HP:0010907)1.95486699
140Abnormality of the axillary hair (HP:0100134)1.93483592
141Abnormality of secondary sexual hair (HP:0009888)1.93483592
142Back pain (HP:0003418)1.92209259
143Axonal loss (HP:0003447)1.91887174
144Patellar dislocation (HP:0002999)1.91814120
145Deviation of the hallux (HP:0010051)1.91100094
146Cerebral edema (HP:0002181)1.90472735
147Abnormal cartilage morphology (HP:0002763)1.88838134
148Abnormality of the gallbladder (HP:0005264)1.87782185
149Hyperinsulinemic hypoglycemia (HP:0000825)1.87650777
150Pterygium (HP:0001059)1.87355613
151Aortic aneurysm (HP:0004942)1.87056926
152Opisthotonus (HP:0002179)1.85620647
153Nephritis (HP:0000123)1.84375038
154Precocious puberty (HP:0000826)1.84316670
155Aortic dissection (HP:0002647)1.83126389
156Increased nuchal translucency (HP:0010880)1.82527146
157Brushfield spots (HP:0001088)1.82310095
158Abnormal enzyme/coenzyme activity (HP:0012379)1.82112364
159Late onset (HP:0003584)1.81490083
160Peritonitis (HP:0002586)1.79204749
161Renal cortical cysts (HP:0000803)1.78963640
162Follicular hyperkeratosis (HP:0007502)1.78789107
163Ulnar bowing (HP:0003031)1.77512029
164Bronchomalacia (HP:0002780)1.76812223
165Neonatal short-limb short stature (HP:0008921)1.76127502
166Biconcave vertebral bodies (HP:0004586)1.74789134
167Turricephaly (HP:0000262)1.74578465
168Increased variability in muscle fiber diameter (HP:0003557)1.71734616
169Vomiting (HP:0002013)1.70879775
170Elevated hepatic transaminases (HP:0002910)1.70263094
171Hypoplasia of dental enamel (HP:0006297)1.70080999
172Limb-girdle muscle weakness (HP:0003325)1.69818608
173Vertebral hypoplasia (HP:0008417)1.68854420
174Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.68854420
175Hypercalcemia (HP:0003072)1.67904952
176Abnormality of iron homeostasis (HP:0011031)1.67206091
177Hypoplasia of the iris (HP:0007676)1.66815710
178Ridged nail (HP:0001807)1.66690135
179Tibial bowing (HP:0002982)1.66679981
180Abnormality of transition element cation homeostasis (HP:0011030)1.66404609
181Poikilocytosis (HP:0004447)1.66251032
182Distal lower limb amyotrophy (HP:0008944)1.66117076
183Abnormal biliary tract physiology (HP:0012439)1.65865928
184Aneurysm (HP:0002617)1.64037207
185Increased connective tissue (HP:0009025)1.63070238
186Renal tubular acidosis (HP:0001947)1.62658263
187Palmoplantar hyperkeratosis (HP:0000972)1.61408535
188Oligodontia (HP:0000677)1.60743215
189Abnormality of the gastric mucosa (HP:0004295)1.59873026
190Open mouth (HP:0000194)1.59167259
191Broad metatarsal (HP:0001783)1.59010907
192Neonatal death (HP:0003811)1.57334657
193Long toe (HP:0010511)1.57316261
194Hypoplastic toenails (HP:0001800)1.56357075
195Difficulty climbing stairs (HP:0003551)1.54504685
196Right ventricular cardiomyopathy (HP:0011663)1.54281566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.90011317
2SIK14.75187491
3FGFR44.41644505
4ERN14.36678989
5LATS13.62836607
6NTRK13.40858252
7INSRR3.25167882
8MST1R2.64825697
9TAOK32.59152555
10FRK2.32306538
11FGFR22.24640722
12MOS2.13111172
13EPHA31.98155615
14TTN1.90376839
15SMG11.88616827
16NEK91.83447842
17MAP2K41.80422701
18STK38L1.78383008
19PTK61.71068079
20PIK3CG1.68832215
21PNCK1.65156830
22TRIB31.63805725
23ICK1.57997323
24LMTK21.45143162
25ROCK21.44045081
26MET1.42873512
27PHKG11.41329945
28PHKG21.41329945
29MAP3K71.40658781
30EPHB11.35436752
31MARK11.32307140
32PAK61.28768633
33TYK21.26995859
34PRKAA21.26089978
35JAK11.25374972
36EPHA21.22637146
37FGFR31.19340836
38ABL21.17465122
39NEK61.16174688
40PDGFRA1.14152308
41TRPM71.13207894
42LIMK11.12373548
43STK381.10888064
44NTRK31.10335044
45* ERBB41.09361067
46CAMK1D1.07329470
47EPHB21.06115618
48EEF2K1.04791246
49PTK21.04494005
50PIK3CA1.03800854
51NTRK21.03299491
52MAPK151.01645644
53RIPK11.00740776
54ROCK10.99457280
55TYRO30.98915120
56FER0.98860912
57MAP3K140.95032012
58MAP3K30.94637009
59DAPK20.94369202
60CDK60.90954253
61PKN20.90495094
62LATS20.90060270
63KSR10.89734083
64CDK120.88747571
65PAK40.86775429
66DYRK1B0.86000762
67GSK3A0.85426541
68FLT30.84356885
69DDR20.82717539
70STK30.80820603
71NUAK10.80414411
72PAK30.78746999
73PRKCZ0.77352403
74PRKD30.77081015
75TGFBR20.76850635
76SGK30.76615381
77* MAPK110.74464347
78MAPK40.72947475
79SGK20.72599412
80PRKAA10.69454015
81KSR20.68568177
82SCYL20.68553596
83BMX0.67444241
84MAPK70.66842249
85IRAK10.65253451
86IGF1R0.63864847
87PRKACG0.63662092
88CDK80.63020230
89CAMK2D0.62487573
90MTOR0.62087642
91TTK0.61736681
92MAP2K10.59369847
93PRKD20.59242830
94IRAK30.59095001
95MAPK120.58979818
96* JAK20.56519245
97FGFR10.56214666
98MAP3K100.55867839
99MAP3K60.54099981
100TBK10.52959566
101CAMK1G0.52219047
102TESK10.51644545
103SGK4940.51627869
104SGK2230.51627869
105CSNK1G10.51389957
106CAMK2B0.51371332
107* ERBB20.51218274
108ERBB30.51065332
109GRK10.47935100
110MAP3K20.47330685
111AKT30.47106749
112ARAF0.47047370
113MAPK100.45619036
114MAPKAPK20.45276376
115RET0.45098651
116CHUK0.44410907
117CSK0.40873732
118NLK0.40151634
119* SRC0.39900720
120CDC42BPA0.39738084
121MAP3K130.39493596
122BRSK10.39023089
123PDGFRB0.38090560
124TAOK20.37956263
125ILK0.37695086
126PRKCQ0.37527670
127* PKN10.37354366
128GRK60.36465096
129PINK10.36023874
130PAK20.35470771
131MYLK0.35326733
132MAP3K80.35056523
133KDR0.33964767
134MELK0.33802893
135EPHA40.33753541
136IKBKE0.33105667
137RPS6KA20.32843876
138MAP2K30.32723674
139MAP3K10.32471421
140AKT20.32342737
141IRAK20.30798808
142PBK0.30534540
143MAP3K50.29466351
144PRKCI0.29288533
145PRKCH0.29154778
146CSF1R0.28694815
147LRRK20.28633149
148PDPK10.27236960
149PRKD10.26750233
150CSNK1A1L0.26713773
151CAMK40.26676116
152* CAMK2G0.26063042
153EIF2AK10.24252936
154PRKDC0.23972248

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.79894897
2Nitrogen metabolism_Homo sapiens_hsa009103.86950419
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27084316
4Complement and coagulation cascades_Homo sapiens_hsa046103.09122395
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.06939231
6Arginine biosynthesis_Homo sapiens_hsa002203.06306932
7Tryptophan metabolism_Homo sapiens_hsa003802.69555050
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55776428
9Fatty acid degradation_Homo sapiens_hsa000712.47159649
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46545764
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44977015
12* Focal adhesion_Homo sapiens_hsa045102.43760503
13Notch signaling pathway_Homo sapiens_hsa043302.40022989
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26950337
15Renal cell carcinoma_Homo sapiens_hsa052112.19627387
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18480342
17Peroxisome_Homo sapiens_hsa041462.07556515
18Butanoate metabolism_Homo sapiens_hsa006502.07240833
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06048998
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04540101
21PPAR signaling pathway_Homo sapiens_hsa033201.97702955
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.95044160
23Histidine metabolism_Homo sapiens_hsa003401.88815749
24Chemical carcinogenesis_Homo sapiens_hsa052041.86676294
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85281445
26Fatty acid metabolism_Homo sapiens_hsa012121.84346032
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82382377
28Propanoate metabolism_Homo sapiens_hsa006401.81140802
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.80854092
30Caffeine metabolism_Homo sapiens_hsa002321.79227316
31Staphylococcus aureus infection_Homo sapiens_hsa051501.79171442
32Vibrio cholerae infection_Homo sapiens_hsa051101.79092458
33* Pancreatic cancer_Homo sapiens_hsa052121.78752404
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71743770
35Retinol metabolism_Homo sapiens_hsa008301.71725048
36Small cell lung cancer_Homo sapiens_hsa052221.70152297
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69034116
38* Proteoglycans in cancer_Homo sapiens_hsa052051.67912538
39* MicroRNAs in cancer_Homo sapiens_hsa052061.66402263
40mTOR signaling pathway_Homo sapiens_hsa041501.65704586
41beta-Alanine metabolism_Homo sapiens_hsa004101.65628392
42Phenylalanine metabolism_Homo sapiens_hsa003601.63663563
43VEGF signaling pathway_Homo sapiens_hsa043701.62591564
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57937889
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56066095
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55354999
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.53660931
48Selenocompound metabolism_Homo sapiens_hsa004501.52671451
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.52665582
50* Adherens junction_Homo sapiens_hsa045201.52448378
51Tyrosine metabolism_Homo sapiens_hsa003501.51854813
52Bile secretion_Homo sapiens_hsa049761.51413766
53Chronic myeloid leukemia_Homo sapiens_hsa052201.49454446
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40036758
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36372303
56Sulfur metabolism_Homo sapiens_hsa009201.34686439
57* Central carbon metabolism in cancer_Homo sapiens_hsa052301.34230203
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33507484
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32613747
60* Glioma_Homo sapiens_hsa052141.32586761
61Steroid biosynthesis_Homo sapiens_hsa001001.32190660
62Starch and sucrose metabolism_Homo sapiens_hsa005001.29081124
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28428731
64Fatty acid elongation_Homo sapiens_hsa000621.26613983
65Dilated cardiomyopathy_Homo sapiens_hsa054141.26048397
66ABC transporters_Homo sapiens_hsa020101.22625569
67Pyruvate metabolism_Homo sapiens_hsa006201.18274750
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.15540732
69Maturity onset diabetes of the young_Homo sapiens_hsa049501.10891297
70* ErbB signaling pathway_Homo sapiens_hsa040121.10576752
71Fat digestion and absorption_Homo sapiens_hsa049751.10332107
72* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10180988
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09228187
74* Estrogen signaling pathway_Homo sapiens_hsa049151.06549616
75* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06062966
76* Endometrial cancer_Homo sapiens_hsa052131.05901285
77Vitamin B6 metabolism_Homo sapiens_hsa007501.05711951
78Biosynthesis of amino acids_Homo sapiens_hsa012301.03968093
79Folate biosynthesis_Homo sapiens_hsa007901.03392212
80* Dorso-ventral axis formation_Homo sapiens_hsa043201.02785515
81* Phospholipase D signaling pathway_Homo sapiens_hsa040720.99035876
82Hippo signaling pathway_Homo sapiens_hsa043900.98890575
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.97227065
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96491361
85Carbon metabolism_Homo sapiens_hsa012000.95688378
86* Pathways in cancer_Homo sapiens_hsa052000.94064776
87Vitamin digestion and absorption_Homo sapiens_hsa049770.93217152
88* Choline metabolism in cancer_Homo sapiens_hsa052310.92969250
89Axon guidance_Homo sapiens_hsa043600.90385595
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89722919
91* Non-small cell lung cancer_Homo sapiens_hsa052230.88993330
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.88852300
93Arginine and proline metabolism_Homo sapiens_hsa003300.88165735
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87633320
95Lysine degradation_Homo sapiens_hsa003100.86858871
96Thyroid cancer_Homo sapiens_hsa052160.85425591
97Fatty acid biosynthesis_Homo sapiens_hsa000610.84057074
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83179923
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79845836
100Tight junction_Homo sapiens_hsa045300.79509499
101Sulfur relay system_Homo sapiens_hsa041220.79460709
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78890042
103* Rap1 signaling pathway_Homo sapiens_hsa040150.77320786
104* HIF-1 signaling pathway_Homo sapiens_hsa040660.71738097
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69847413
106Inositol phosphate metabolism_Homo sapiens_hsa005620.69193613
107TGF-beta signaling pathway_Homo sapiens_hsa043500.68035337
108Prion diseases_Homo sapiens_hsa050200.66670542
109Hedgehog signaling pathway_Homo sapiens_hsa043400.66449747
110Gastric acid secretion_Homo sapiens_hsa049710.65950484
111* Melanoma_Homo sapiens_hsa052180.64961170
112One carbon pool by folate_Homo sapiens_hsa006700.63588302
113Glutathione metabolism_Homo sapiens_hsa004800.63381308
114Glycerolipid metabolism_Homo sapiens_hsa005610.60787410
115Other glycan degradation_Homo sapiens_hsa005110.60388252
116* Ras signaling pathway_Homo sapiens_hsa040140.59856089
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.59662873
118Prolactin signaling pathway_Homo sapiens_hsa049170.57945419
119Melanogenesis_Homo sapiens_hsa049160.57080022
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56648118
121Glutamatergic synapse_Homo sapiens_hsa047240.53413880
122Sphingolipid metabolism_Homo sapiens_hsa006000.53185289
123* Endocytosis_Homo sapiens_hsa041440.51878044
124Pancreatic secretion_Homo sapiens_hsa049720.49276167
125* Gap junction_Homo sapiens_hsa045400.49237287
126* Prostate cancer_Homo sapiens_hsa052150.45892659
127* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44710800
128Colorectal cancer_Homo sapiens_hsa052100.43971798
129* GnRH signaling pathway_Homo sapiens_hsa049120.42476382
130Pentose phosphate pathway_Homo sapiens_hsa000300.41679425
131Long-term depression_Homo sapiens_hsa047300.39873727
132Metabolic pathways_Homo sapiens_hsa011000.39225116
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38594719
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.38477364
135Mineral absorption_Homo sapiens_hsa049780.37531438
136Insulin resistance_Homo sapiens_hsa049310.32464463
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.32156810
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29656540
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22455745
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21314888
141Linoleic acid metabolism_Homo sapiens_hsa005910.16286964
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15856288
143Glucagon signaling pathway_Homo sapiens_hsa049220.15348896
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.13131342
145Galactose metabolism_Homo sapiens_hsa000520.12934293
146Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12349866
147Fructose and mannose metabolism_Homo sapiens_hsa000510.10888628
148AMPK signaling pathway_Homo sapiens_hsa041520.09280339
149Ovarian steroidogenesis_Homo sapiens_hsa049130.07356815
150Amoebiasis_Homo sapiens_hsa051460.03568060
151ECM-receptor interaction_Homo sapiens_hsa045120.00853786
152* Bladder cancer_Homo sapiens_hsa05219-0.1700462
153Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1642282
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1590943
155Circadian rhythm_Homo sapiens_hsa04710-0.1576982
156Malaria_Homo sapiens_hsa05144-0.1566453
157Renin-angiotensin system_Homo sapiens_hsa04614-0.1546403
158Basal cell carcinoma_Homo sapiens_hsa05217-0.1503209
159* Hepatitis C_Homo sapiens_hsa05160-0.1383687
160African trypanosomiasis_Homo sapiens_hsa05143-0.1292004
161Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1243528
162Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1200263
163Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1139462
164Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1092330
165Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0892195
166Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0854726
167Insulin signaling pathway_Homo sapiens_hsa04910-0.0575109
168Protein digestion and absorption_Homo sapiens_hsa04974-0.0403419

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