EGFLAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)9.03107886
2muscle filament sliding (GO:0030049)9.03107886
3regulation of rhodopsin mediated signaling pathway (GO:0022400)8.97732106
4rhodopsin mediated signaling pathway (GO:0016056)8.70866446
5photoreceptor cell maintenance (GO:0045494)8.10163555
6actin-mediated cell contraction (GO:0070252)7.63880357
7retinal cone cell development (GO:0046549)7.53715114
8photoreceptor cell development (GO:0042461)7.51581365
9eye photoreceptor cell development (GO:0042462)7.00196979
10retinal rod cell development (GO:0046548)6.93456591
11sarcoplasmic reticulum calcium ion transport (GO:0070296)6.65980544
12photoreceptor cell differentiation (GO:0046530)6.17057715
13eye photoreceptor cell differentiation (GO:0001754)6.17057715
14skeletal muscle contraction (GO:0003009)6.13917667
15phototransduction (GO:0007602)6.11856032
16regulation of relaxation of muscle (GO:1901077)5.97837539
17phototransduction, visible light (GO:0007603)5.82516299
18detection of light stimulus (GO:0009583)5.76860488
19sarcomere organization (GO:0045214)5.63078221
20visual perception (GO:0007601)5.56534825
21actin filament-based movement (GO:0030048)5.55779376
22detection of visible light (GO:0009584)5.53568001
23detection of light stimulus involved in visual perception (GO:0050908)5.50904089
24detection of light stimulus involved in sensory perception (GO:0050962)5.50904089
25sensory perception of light stimulus (GO:0050953)5.49541072
26GMP metabolic process (GO:0046037)5.25694025
27response to muscle activity (GO:0014850)5.14274207
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.14167162
29gonadal mesoderm development (GO:0007506)5.12084945
30striated muscle contraction (GO:0006941)4.97537054
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.80879188
32response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.64787174
33retina development in camera-type eye (GO:0060041)4.62249479
34glycogen catabolic process (GO:0005980)4.56691958
35actomyosin structure organization (GO:0031032)4.40358764
36regulation of cell communication by electrical coupling (GO:0010649)4.30447802
37muscle contraction (GO:0006936)4.29679769
38skeletal muscle fiber development (GO:0048741)4.28284558
39glucan catabolic process (GO:0009251)4.23135120
40creatine metabolic process (GO:0006600)4.22909470
41protein-chromophore linkage (GO:0018298)4.21838930
42detection of external stimulus (GO:0009581)4.18352117
43positive regulation of guanylate cyclase activity (GO:0031284)4.17193603
44regulation of actin filament-based movement (GO:1903115)4.15546947
45cardiac muscle contraction (GO:0060048)4.09732741
46myotube cell development (GO:0014904)4.06771962
47detection of abiotic stimulus (GO:0009582)4.04112954
48skeletal muscle tissue development (GO:0007519)4.03940706
49response to inactivity (GO:0014854)4.02048118
50plasma membrane repair (GO:0001778)3.95805934
51cellular polysaccharide catabolic process (GO:0044247)3.86487679
52cellular response to light stimulus (GO:0071482)3.85782962
53muscle system process (GO:0003012)3.83333718
54appendage development (GO:0048736)3.75172386
55limb development (GO:0060173)3.75172386
56negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.74016186
57muscle cell cellular homeostasis (GO:0046716)3.71469085
58regulation of guanylate cyclase activity (GO:0031282)3.70100015
59cardiac muscle hypertrophy (GO:0003300)3.68606379
60carnitine shuttle (GO:0006853)3.65830159
61skeletal muscle adaptation (GO:0043501)3.60453273
62polysaccharide catabolic process (GO:0000272)3.60014263
63muscle tissue morphogenesis (GO:0060415)3.57255847
64regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.57013738
65muscle cell fate commitment (GO:0042693)3.56107334
66regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.54892802
67muscle fiber development (GO:0048747)3.54045873
68fibroblast migration (GO:0010761)3.53328559
69striated muscle hypertrophy (GO:0014897)3.52672446
70metanephric mesenchyme development (GO:0072075)3.49108850
71cardiac muscle tissue morphogenesis (GO:0055008)3.47658927
72regulation of cGMP metabolic process (GO:0030823)3.46261813
73glycogen biosynthetic process (GO:0005978)3.43136086
74glucan biosynthetic process (GO:0009250)3.43136086
75skeletal muscle tissue regeneration (GO:0043403)3.41315791
76lymph vessel development (GO:0001945)3.35462161
77cardiac muscle cell development (GO:0055013)3.33413795
78heart contraction (GO:0060047)3.31633499
79heart process (GO:0003015)3.31633499
80NADH metabolic process (GO:0006734)3.28746953
81response to dexamethasone (GO:0071548)3.24239379
82muscle structure development (GO:0061061)3.21762289
83muscle organ development (GO:0007517)3.21494721
84estrogen biosynthetic process (GO:0006703)3.21381591
85striated muscle adaptation (GO:0014888)3.20049159
86regulation of striated muscle contraction (GO:0006942)3.18835305
87kidney mesenchyme development (GO:0072074)3.17159365
88positive regulation of gastrulation (GO:2000543)3.16346332
89muscle organ morphogenesis (GO:0048644)3.15822179
90glycogen metabolic process (GO:0005977)3.14196514
91striated muscle cell development (GO:0055002)3.13956568
92notochord development (GO:0030903)3.13526138
93fatty acid transmembrane transport (GO:1902001)3.11188333
94regulation of clathrin-mediated endocytosis (GO:2000369)3.10765577
95cardiac cell development (GO:0055006)3.10145123
96regulation of sequestering of triglyceride (GO:0010889)3.09900552
97muscle hypertrophy (GO:0014896)3.07973518
98cellular glucan metabolic process (GO:0006073)3.05945106
99glucan metabolic process (GO:0044042)3.05945106
100adult heart development (GO:0007512)3.03703652
101cardiac myofibril assembly (GO:0055003)2.99406207
102response to epinephrine (GO:0071871)2.97627793
103response to activity (GO:0014823)2.97003237
104positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.96132320
105positive regulation of hormone biosynthetic process (GO:0046886)2.95183502
106fusion of sperm to egg plasma membrane (GO:0007342)2.95122657
107striated muscle tissue development (GO:0014706)2.94878441
108cell migration involved in heart development (GO:0060973)2.94543266
109regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.94281532
110negative regulation of protein localization to cell surface (GO:2000009)2.93710219
111positive regulation of odontogenesis (GO:0042482)2.91966778
112carnitine transmembrane transport (GO:1902603)2.91839380
113nonmotile primary cilium assembly (GO:0035058)2.87928525
114positive regulation of cGMP metabolic process (GO:0030825)2.86065003
115muscle cell development (GO:0055001)2.82912863
116endocardial cushion morphogenesis (GO:0003203)2.82343900
117tricarboxylic acid cycle (GO:0006099)2.81972001
118positive regulation of cGMP biosynthetic process (GO:0030828)2.81657210
119positive regulation of catecholamine secretion (GO:0033605)2.81469724
120cardiac muscle hypertrophy in response to stress (GO:0014898)2.80247263
121muscle hypertrophy in response to stress (GO:0003299)2.80247263
122cardiac muscle adaptation (GO:0014887)2.80247263
123cilium or flagellum-dependent cell motility (GO:0001539)2.77924996
124muscle tissue development (GO:0060537)2.77637170
125paraxial mesoderm development (GO:0048339)2.76644987
126regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75773485
127regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.75717647
128myoblast fusion (GO:0007520)2.73676543
129receptor guanylyl cyclase signaling pathway (GO:0007168)2.73451348
130regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.71917948
131positive regulation of myotube differentiation (GO:0010831)2.71901688
132cellular response to epinephrine stimulus (GO:0071872)2.70008266
133amino-acid betaine transport (GO:0015838)2.69299297
134carnitine transport (GO:0015879)2.69299297
135regulation of myoblast differentiation (GO:0045661)2.68652423
136positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.68541189
137negative regulation of Rho protein signal transduction (GO:0035024)2.68016625
138retina layer formation (GO:0010842)2.66165563
139glomerulus development (GO:0032835)2.65468530
140embryonic foregut morphogenesis (GO:0048617)2.65452415
141cGMP-mediated signaling (GO:0019934)2.65300663
142midgut development (GO:0007494)2.61813818
143regulation of cGMP biosynthetic process (GO:0030826)2.60407595
144negative regulation of receptor-mediated endocytosis (GO:0048261)2.59338287
145epithelial cell fate commitment (GO:0072148)2.56028739
146lipid particle organization (GO:0034389)2.55360936
147regulation of axon extension involved in axon guidance (GO:0048841)2.55270754
148sensory perception (GO:0007600)2.53251327
149cytoplasmic mRNA processing body assembly (GO:0033962)2.51997905
150endocardial cushion development (GO:0003197)2.49630067
151mesenchyme morphogenesis (GO:0072132)2.45544141
152myelination in peripheral nervous system (GO:0022011)2.45460866
153peripheral nervous system axon ensheathment (GO:0032292)2.45460866
154vascular endothelial growth factor signaling pathway (GO:0038084)2.45339031
155plasma membrane fusion (GO:0045026)2.44639903
156myofibril assembly (GO:0030239)2.44074022
157surfactant homeostasis (GO:0043129)2.42644966
158protein heterotrimerization (GO:0070208)2.42051940
159regulation of cardioblast differentiation (GO:0051890)2.39311671
160retina vasculature morphogenesis in camera-type eye (GO:0061299)2.38050129
161regulation of skeletal muscle contraction (GO:0014819)2.37398563
162sex determination (GO:0007530)2.36618887
163cellular response to radiation (GO:0071478)2.36600931
164glomerular filtration (GO:0003094)2.35235823
165Leydig cell differentiation (GO:0033327)2.34698544
166regulation of axon guidance (GO:1902667)2.33076923
167negative regulation of potassium ion transmembrane transport (GO:1901380)2.32616971
168potassium ion import (GO:0010107)2.31656140
169negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.30861380
170negative regulation of axon extension involved in axon guidance (GO:0048843)2.30460224
171lung vasculature development (GO:0060426)2.29372080
172neuron development (GO:0048666)2.26548224
173positive regulation of sodium ion transmembrane transport (GO:1902307)2.26354841
174positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.25742587
175axoneme assembly (GO:0035082)2.24465682
176camera-type eye morphogenesis (GO:0048593)2.23640016
177hippo signaling (GO:0035329)2.23198141
178peptidyl-tyrosine autophosphorylation (GO:0038083)2.23022895
179vasculature development (GO:0001944)2.21521653
180motile cilium assembly (GO:0044458)2.19605534
181regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.19379775
182regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.18596282
183piRNA metabolic process (GO:0034587)2.18529771
184aorta morphogenesis (GO:0035909)2.16798773
185renal filtration (GO:0097205)2.15597944
186neuron remodeling (GO:0016322)2.14980909
187blood vessel maturation (GO:0001955)2.13738131
188response to light stimulus (GO:0009416)2.13538091
189negative regulation of catenin import into nucleus (GO:0035414)2.13436132
190lymphangiogenesis (GO:0001946)2.12029293
191CDP-diacylglycerol biosynthetic process (GO:0016024)2.11348871
192coronary vasculature morphogenesis (GO:0060977)2.10019674
193regulation of vasculogenesis (GO:2001212)2.09209601
194cell morphogenesis involved in neuron differentiation (GO:0048667)2.09095938
195dorsal/ventral axis specification (GO:0009950)2.08787943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.23711688
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.31339026
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.29960415
4ZNF263_19887448_ChIP-Seq_K562_Human3.07519004
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89156280
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.86805858
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.77357098
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70421963
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.64520212
10EZH2_22144423_ChIP-Seq_EOC_Human2.55956397
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.36725075
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28927941
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.24063128
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.14500532
15MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.09465791
16* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93513794
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91982297
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91151458
19GATA1_22025678_ChIP-Seq_K562_Human1.86194812
20ISL1_27105846_Chip-Seq_CPCs_Mouse1.82860412
21* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74808157
22* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74808157
23DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.73970729
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.68132752
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66101012
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64582443
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.63221072
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62655367
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61215080
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59945243
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.59399495
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.58773834
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57734892
34CLOCK_20551151_ChIP-Seq_293T_Human1.57305120
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56682096
36DROSHA_22980978_ChIP-Seq_HELA_Human1.56492550
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.56467740
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.56467740
39NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.56389290
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.55931995
41CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.53516137
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.52313759
43* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49305991
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47492101
45KDM2B_26808549_Chip-Seq_K562_Human1.47163017
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46059617
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44939697
48* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43507623
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.41121297
50DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39726982
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38212047
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37852867
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37772175
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37615591
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.36679075
56PHF8_20622853_ChIP-Seq_HELA_Human1.36016653
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35847717
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.35188702
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.34051605
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33333913
61GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.32294453
62* RING1B_27294783_Chip-Seq_NPCs_Mouse1.31263133
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30911234
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29545926
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29389809
66ZNF274_21170338_ChIP-Seq_K562_Hela1.28885940
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28693816
68FUS_26573619_Chip-Seq_HEK293_Human1.28354812
69* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27451255
70BRD4_25478319_ChIP-Seq_HGPS_Human1.27090555
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26835411
72GATA4_21415370_ChIP-Seq_HL-1_Mouse1.26717840
73STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.26625503
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26107048
75ETV1_20927104_ChIP-Seq_GIST48_Human1.25569378
76NFYB_21822215_ChIP-Seq_K562_Human1.24814484
77HNFA_21074721_ChIP-Seq_CACO-2_Human1.24794827
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24373454
79IGF1R_20145208_ChIP-Seq_DFB_Human1.23265726
80BCAT_22108803_ChIP-Seq_LS180_Human1.22745757
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.22690908
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21642246
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21176553
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.19505143
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.18102944
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18020193
87* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17824818
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17760231
89AHR_22903824_ChIP-Seq_MCF-7_Human1.17335604
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17328915
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16982855
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16982855
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16948962
94VDR_22108803_ChIP-Seq_LS180_Human1.13862326
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12980360
96* SMAD3_21741376_ChIP-Seq_HESCs_Human1.12485300
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12293736
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12124083
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11118172
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09882527
101AR_19668381_ChIP-Seq_PC3_Human1.09812799
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09499544
103CTCF_27219007_Chip-Seq_Bcells_Human1.08518821
104RBPJ_21746931_ChIP-Seq_IB4_Human1.08516337
105AR_21909140_ChIP-Seq_LNCAP_Human1.08335310
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.07972734
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07565119
108* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06382613
109* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05366748
110CBX2_22325352_ChIP-Seq_293T-Rex_Human1.04311217
111TBL1_22424771_ChIP-Seq_293T_Human1.04215943
112* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03522046
113* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03418793
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03314109
115CBP_21632823_ChIP-Seq_H3396_Human1.03179110
116TP53_18474530_ChIP-ChIP_U2OS_Human1.03132765
117GBX2_23144817_ChIP-Seq_PC3_Human1.02049832
118WDR5_24793694_ChIP-Seq_LNCAP_Human1.01880742
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99967245
120* CJUN_26792858_Chip-Seq_BT549_Human0.99288323
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99048953
122* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98340039
123NFYA_21822215_ChIP-Seq_K562_Human0.96589292
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96326714
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95637065
126SOX9_26525672_Chip-Seq_HEART_Mouse0.95539878
127WT1_19549856_ChIP-ChIP_CCG9911_Human0.94458910
128HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94151863
129* KDM2B_26808549_Chip-Seq_JURKAT_Human0.93739081
130FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93204711
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93156081
132* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92938557
133FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92787458
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92496691
135* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92047414
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91564247
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91262756
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91032873
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91032873
140UBF1/2_26484160_Chip-Seq_HMECs_Human0.90996936
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90534178
142* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90513172
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89751455
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89602414
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.89098123
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.88986967
147RUNX1_27514584_Chip-Seq_MCF-7_Human0.88897635
148TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88170825
149CREB1_26743006_Chip-Seq_LNCaP_Human0.88101342
150P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87685993
151ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87593178
152SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87378825
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.87323374
154GF1B_26923725_Chip-Seq_HPCs_Mouse0.86501083
155* SMAD4_21799915_ChIP-Seq_A2780_Human0.86401607
156KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86391608
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86380246
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86232017
159SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86040323
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.85341844
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84191391

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation7.24505722
2* MP0005551_abnormal_eye_electrophysiolog6.52055668
3MP0006072_abnormal_retinal_apoptosis5.36665939
4* MP0005253_abnormal_eye_physiology4.71916093
5* MP0005195_abnormal_posterior_eye3.02905006
6MP0003950_abnormal_plasma_membrane2.65548297
7MP0002653_abnormal_ependyma_morphology2.61603215
8* MP0005391_vision/eye_phenotype2.58662507
9MP0001324_abnormal_eye_pigmentation2.57517175
10MP0004272_abnormal_basement_membrane2.56928577
11MP0002269_muscular_atrophy2.49729559
12MP0008438_abnormal_cutaneous_collagen2.38985640
13MP0000751_myopathy2.31376806
14MP0005670_abnormal_white_adipose2.26328888
15MP0005623_abnormal_meninges_morphology2.01860585
16MP0001879_abnormal_lymphatic_vessel1.89402864
17MP0005503_abnormal_tendon_morphology1.81335115
18MP0002090_abnormal_vision1.74399933
19MP0004084_abnormal_cardiac_muscle1.72157887
20MP0004145_abnormal_muscle_electrophysio1.67494770
21MP0010030_abnormal_orbit_morphology1.63381920
22MP0005275_abnormal_skin_tensile1.58034509
23MP0004036_abnormal_muscle_relaxation1.57079380
24MP0002127_abnormal_cardiovascular_syste1.56672522
25MP0004233_abnormal_muscle_weight1.54728994
26MP0002229_neurodegeneration1.53166596
27MP0005451_abnormal_body_composition1.50620903
28MP0005410_abnormal_fertilization1.49487951
29MP0001958_emphysema1.48142967
30* MP0002752_abnormal_somatic_nervous1.43197233
31MP0002108_abnormal_muscle_morphology1.42106000
32MP0002234_abnormal_pharynx_morphology1.40318825
33MP0002971_abnormal_brown_adipose1.39620835
34MP0010368_abnormal_lymphatic_system1.32993515
35MP0006036_abnormal_mitochondrial_physio1.31984812
36MP0005666_abnormal_adipose_tissue1.29260763
37MP0004484_altered_response_of1.27861602
38MP0009384_cardiac_valve_regurgitation1.24116653
39MP0004215_abnormal_myocardial_fiber1.23534239
40MP0002638_abnormal_pupillary_reflex1.21475362
41MP0005620_abnormal_muscle_contractility1.17358439
42MP0004885_abnormal_endolymph1.15931893
43MP0005187_abnormal_penis_morphology1.14309983
44MP0005248_abnormal_Harderian_gland1.11806457
45MP0000534_abnormal_ureter_morphology1.11670232
46MP0008995_early_reproductive_senescence1.11186575
47MP0000762_abnormal_tongue_morphology1.09644253
48MP0003705_abnormal_hypodermis_morpholog1.09480743
49MP0002822_catalepsy1.05132886
50MP0004087_abnormal_muscle_fiber1.04377692
51MP0001293_anophthalmia1.03454191
52MP0001502_abnormal_circadian_rhythm1.01652454
53MP0003942_abnormal_urinary_system1.01045312
54MP0002697_abnormal_eye_size0.99511048
55MP0002837_dystrophic_cardiac_calcinosis0.98815402
56MP0006138_congestive_heart_failure0.98501977
57MP0003385_abnormal_body_wall0.97535469
58MP0000767_abnormal_smooth_muscle0.97250042
59MP0003122_maternal_imprinting0.97195124
60MP0000749_muscle_degeneration0.96384750
61MP0005330_cardiomyopathy0.95460589
62* MP0002882_abnormal_neuron_morphology0.93301655
63MP0010630_abnormal_cardiac_muscle0.93009827
64MP0003115_abnormal_respiratory_system0.92654436
65MP0005083_abnormal_biliary_tract0.92628260
66MP0005266_abnormal_metabolism0.92090633
67MP0000733_abnormal_muscle_development0.91879147
68MP0000537_abnormal_urethra_morphology0.90443487
69MP0002282_abnormal_trachea_morphology0.89304516
70MP0003828_pulmonary_edema0.89068398
71MP0003045_fibrosis0.87315990
72MP0003646_muscle_fatigue0.86828494
73MP0003137_abnormal_impulse_conducting0.84756601
74MP0000003_abnormal_adipose_tissue0.84468732
75MP0005197_abnormal_uvea_morphology0.84345823
76MP0000428_abnormal_craniofacial_morphol0.83854522
77MP0005369_muscle_phenotype0.83789541
78MP0000750_abnormal_muscle_regeneration0.83428078
79MP0000462_abnormal_digestive_system0.83079994
80MP0000759_abnormal_skeletal_muscle0.82724743
81MP0002106_abnormal_muscle_physiology0.82605807
82MP0003935_abnormal_craniofacial_develop0.81305518
83MP0002972_abnormal_cardiac_muscle0.79522862
84MP0008789_abnormal_olfactory_epithelium0.78653590
85MP0004085_abnormal_heartbeat0.78050271
86MP0009780_abnormal_chondrocyte_physiolo0.76550987
87MP0001286_abnormal_eye_development0.76303756
88MP0003279_aneurysm0.76186825
89MP0000266_abnormal_heart_morphology0.75743129
90MP0003634_abnormal_glial_cell0.75676263
91MP0001346_abnormal_lacrimal_gland0.75598244
92MP0003119_abnormal_digestive_system0.75214945
93MP0003890_abnormal_embryonic-extraembry0.75156324
94MP0009250_abnormal_appendicular_skeleto0.74658363
95MP0004185_abnormal_adipocyte_glucose0.74654389
96MP0004130_abnormal_muscle_cell0.73634033
97MP0008775_abnormal_heart_ventricle0.72997094
98MP0002925_abnormal_cardiovascular_devel0.69861898
99MP0001614_abnormal_blood_vessel0.69624444
100MP0003698_abnormal_male_reproductive0.68575665
101MP0000747_muscle_weakness0.67544405
102MP0002938_white_spotting0.66678201
103MP0003221_abnormal_cardiomyocyte_apopto0.66677570
104MP0001544_abnormal_cardiovascular_syste0.66475837
105MP0005385_cardiovascular_system_phenoty0.66475837
106MP0004510_myositis0.66143804
107MP0002114_abnormal_axial_skeleton0.64938358
108MP0005394_taste/olfaction_phenotype0.64873569
109MP0005499_abnormal_olfactory_system0.64873569
110MP0001661_extended_life_span0.64024073
111MP0005375_adipose_tissue_phenotype0.63748714
112MP0003959_abnormal_lean_body0.63401428
113MP0000049_abnormal_middle_ear0.63044573
114MP0002092_abnormal_eye_morphology0.62985936
115MP0005595_abnormal_vascular_smooth0.62892594
116MP0003283_abnormal_digestive_organ0.62320743
117MP0001299_abnormal_eye_distance/0.62245949
118MP0002128_abnormal_blood_circulation0.62198624
119MP0000013_abnormal_adipose_tissue0.61818356
120MP0002896_abnormal_bone_mineralization0.61393568
121MP0003567_abnormal_fetal_cardiomyocyte0.61265822
122MP0002332_abnormal_exercise_endurance0.60913839
123MP0002168_other_aberrant_phenotype0.60359208
124MP0003566_abnormal_cell_adhesion0.58306658
125MP0009115_abnormal_fat_cell0.54838120
126MP0003755_abnormal_palate_morphology0.53375044
127MP0002932_abnormal_joint_morphology0.51144914
128MP0005165_increased_susceptibility_to0.50535525
129MP0000230_abnormal_systemic_arterial0.49337017
130MP0003879_abnormal_hair_cell0.48876982
131MP0005409_darkened_coat_color0.48429874
132MP0003136_yellow_coat_color0.47595533
133MP0005508_abnormal_skeleton_morphology0.47343887
134MP0002233_abnormal_nose_morphology0.46314538
135MP0002876_abnormal_thyroid_physiology0.44804406
136MP0009697_abnormal_copulation0.44754890
137MP0005647_abnormal_sex_gland0.43804336
138MP0003941_abnormal_skin_development0.43462577
139MP0003984_embryonic_growth_retardation0.41728074
140MP0002088_abnormal_embryonic_growth/wei0.41532000

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)8.90221958
2Muscle fiber inclusion bodies (HP:0100299)8.68819284
3Nemaline bodies (HP:0003798)8.61272839
4Congenital stationary night blindness (HP:0007642)8.51081026
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.47575201
6Chorioretinal atrophy (HP:0000533)8.31137363
7Bony spicule pigmentary retinopathy (HP:0007737)8.05907206
8Abnormal rod and cone electroretinograms (HP:0008323)7.92239020
9Pigmentary retinal degeneration (HP:0001146)7.81063683
10Central scotoma (HP:0000603)7.55220512
11Abolished electroretinogram (ERG) (HP:0000550)7.16761499
12Pendular nystagmus (HP:0012043)7.09214732
13Scotoma (HP:0000575)6.69574564
14Dyschromatopsia (HP:0007641)6.53660631
15Posterior subcapsular cataract (HP:0007787)6.29710314
16Abnormality of macular pigmentation (HP:0008002)6.19229981
17Vitreoretinal degeneration (HP:0000655)5.54426761
18Distal arthrogryposis (HP:0005684)5.52495802
19Calcaneovalgus deformity (HP:0001848)4.88190650
20Decreased central vision (HP:0007663)4.82203241
21Increased corneal curvature (HP:0100692)4.66045803
22Keratoconus (HP:0000563)4.66045803
23Type II diabetes mellitus (HP:0005978)4.65400735
24Round ear (HP:0100830)4.60794016
25Attenuation of retinal blood vessels (HP:0007843)4.54752311
26Macular degeneration (HP:0000608)4.52976731
27EMG: myopathic abnormalities (HP:0003458)4.45970338
28Cone-rod dystrophy (HP:0000548)4.40776301
29Myopathic facies (HP:0002058)4.32992831
30Deformed tarsal bones (HP:0008119)4.30101083
31Rhabdomyolysis (HP:0003201)4.23255788
32Myoglobinuria (HP:0002913)4.19544296
33Subcapsular cataract (HP:0000523)4.16105293
34Photophobia (HP:0000613)3.99304781
35Neck muscle weakness (HP:0000467)3.95160661
36Rimmed vacuoles (HP:0003805)3.87642727
37Centrally nucleated skeletal muscle fibers (HP:0003687)3.84896266
38Severe visual impairment (HP:0001141)3.79906635
39Ulnar deviation of the wrist (HP:0003049)3.68463954
40Constricted visual fields (HP:0001133)3.61461755
41Abnormality of the left ventricular outflow tract (HP:0011103)3.52529086
42Subaortic stenosis (HP:0001682)3.52529086
43Absent phalangeal crease (HP:0006109)3.49720544
44Muscle stiffness (HP:0003552)3.16257610
45Myotonia (HP:0002486)3.15907231
46Choroideremia (HP:0001139)3.13835836
47Asymmetric septal hypertrophy (HP:0001670)3.10008746
48Malignant hyperthermia (HP:0002047)3.05178801
49Retinitis pigmentosa (HP:0000510)3.04787527
50Areflexia of lower limbs (HP:0002522)3.03258426
51Abnormal finger flexion creases (HP:0006143)2.93682313
52Abnormality of the calcaneus (HP:0008364)2.91509242
53Lipoatrophy (HP:0100578)2.87816908
54Progressive visual loss (HP:0000529)2.85438566
55Distal lower limb muscle weakness (HP:0009053)2.85281550
56Bundle branch block (HP:0011710)2.75098776
57Scapular winging (HP:0003691)2.74515126
58Weak cry (HP:0001612)2.74055581
59Popliteal pterygium (HP:0009756)2.66382545
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.64241992
61Dilated cardiomyopathy (HP:0001644)2.63036489
62Ventricular tachycardia (HP:0004756)2.52428293
63Frequent falls (HP:0002359)2.52029423
64Gowers sign (HP:0003391)2.51971514
65Bulbar palsy (HP:0001283)2.42769943
66Abnormality of the neuromuscular junction (HP:0003398)2.41736397
67Fatigable weakness (HP:0003473)2.41736397
68Generalized muscle weakness (HP:0003324)2.40208296
69Fetal akinesia sequence (HP:0001989)2.35804758
70Abnormality of the shoulder girdle musculature (HP:0001435)2.30917990
71Type 1 muscle fiber predominance (HP:0003803)2.30616482
72Limb-girdle muscle atrophy (HP:0003797)2.27427106
73Polar cataract (HP:0010696)2.24258836
74Hip contracture (HP:0003273)2.24000219
75EMG: neuropathic changes (HP:0003445)2.19034572
76Wide nasal bridge (HP:0000431)2.14365696
77Ankle contracture (HP:0006466)2.13675888
78Progressive muscle weakness (HP:0003323)2.10587800
79Proximal amyotrophy (HP:0007126)2.02348951
80Heart block (HP:0012722)2.02296180
81Atrial fibrillation (HP:0005110)1.99293947
82Metatarsus adductus (HP:0001840)1.98446478
83Muscular dystrophy (HP:0003560)1.97011580
84Abnormal atrioventricular conduction (HP:0005150)1.96644840
85Congenital sensorineural hearing impairment (HP:0008527)1.90888048
86Aortic aneurysm (HP:0004942)1.90722878
87Retinal atrophy (HP:0001105)1.90663625
88Limited hip movement (HP:0008800)1.89996097
89Short palpebral fissure (HP:0012745)1.89930249
90Severe Myopia (HP:0011003)1.89901175
91Long clavicles (HP:0000890)1.88517198
92Broad metatarsal (HP:0001783)1.87959076
93Distal lower limb amyotrophy (HP:0008944)1.87686518
94Bell-shaped thorax (HP:0001591)1.87328040
95Type 2 muscle fiber atrophy (HP:0003554)1.85540227
96Respiratory insufficiency due to muscle weakness (HP:0002747)1.84347467
97Difficulty climbing stairs (HP:0003551)1.83621775
98Limb-girdle muscle weakness (HP:0003325)1.82473987
99Atrioventricular block (HP:0001678)1.82224355
100Abnormality of the foot musculature (HP:0001436)1.78035457
101Midline defect of the nose (HP:0004122)1.76718474
102Bladder diverticulum (HP:0000015)1.74045107
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73140862
104Right ventricular cardiomyopathy (HP:0011663)1.72453126
105Primary atrial arrhythmia (HP:0001692)1.71704543
106Supraventricular arrhythmia (HP:0005115)1.68397404
107Increased variability in muscle fiber diameter (HP:0003557)1.67609416
108Exercise-induced muscle cramps (HP:0003710)1.67485829
109Hypoventilation (HP:0002791)1.67406644
110Supraventricular tachycardia (HP:0004755)1.67332771
111Foot dorsiflexor weakness (HP:0009027)1.66781472
112Waddling gait (HP:0002515)1.66494643
113Difficulty running (HP:0009046)1.66189845
114Cerebral aneurysm (HP:0004944)1.65068552
115Ragged-red muscle fibers (HP:0003200)1.64617899
116Male infertility (HP:0003251)1.64110655
117Amniotic constriction ring (HP:0009775)1.63844048
118Abnormality of placental membranes (HP:0011409)1.63844048
119Muscle fiber atrophy (HP:0100295)1.62769309
120Hyperkalemia (HP:0002153)1.59350017
121Spinal rigidity (HP:0003306)1.59312603
122Pulmonary artery stenosis (HP:0004415)1.58976945
123Aortic dissection (HP:0002647)1.58892507
124Abnormality of dentin (HP:0010299)1.58164471
125Ventricular arrhythmia (HP:0004308)1.57088194
126Optic disc pallor (HP:0000543)1.54366812
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.54329198
128Absent/shortened dynein arms (HP:0200106)1.54329198
129Interstitial pulmonary disease (HP:0006530)1.53114493
130Follicular hyperkeratosis (HP:0007502)1.51628664
131Congenital primary aphakia (HP:0007707)1.51482508
132Gait imbalance (HP:0002141)1.50936745
133Exercise-induced myalgia (HP:0003738)1.49457775
134Protrusio acetabuli (HP:0003179)1.46898922
135Muscle hypertrophy of the lower extremities (HP:0008968)1.45991220
136Renal duplication (HP:0000075)1.45787944
137Calf muscle hypertrophy (HP:0008981)1.45627113
138Increased connective tissue (HP:0009025)1.44792380
139Abnormality of the calf musculature (HP:0001430)1.42232602
140Renovascular hypertension (HP:0100817)1.40109640
141Medial flaring of the eyebrow (HP:0010747)1.39948608
142Hyporeflexia of lower limbs (HP:0002600)1.38516704
143Lymphangioma (HP:0100764)1.38241137
144Short 4th metacarpal (HP:0010044)1.37288428
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.37288428
146Muscle fiber splitting (HP:0003555)1.36555969
147Abnormality of skeletal muscle fiber size (HP:0012084)1.35083403
148Sclerocornea (HP:0000647)1.34066304
149Anophthalmia (HP:0000528)1.33565714
150Vaginal atresia (HP:0000148)1.33512952
151Mildly elevated creatine phosphokinase (HP:0008180)1.31467788
152Rectal prolapse (HP:0002035)1.31284830
153Retinal detachment (HP:0000541)1.31121874
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.29958536
155Cystic liver disease (HP:0006706)1.29584459
156Genital tract atresia (HP:0001827)1.28848493
157Hypoplastic ischia (HP:0003175)1.24758499
158Prolonged QT interval (HP:0001657)1.24397934
159Nephrogenic diabetes insipidus (HP:0009806)1.24162607
160Infertility (HP:0000789)1.22228350
161Aplasia/Hypoplasia of the lens (HP:0008063)1.21132642
162Hematochezia (HP:0002573)1.17982088
163Abnormality of the parathyroid morphology (HP:0011766)1.17533057
164Joint laxity (HP:0001388)1.17052243
165Abnormality of the 4th metacarpal (HP:0010012)1.16566864
166Male pseudohermaphroditism (HP:0000037)1.15293155
167Abnormal respiratory motile cilium physiology (HP:0012261)1.15288106
168Chronic bronchitis (HP:0004469)1.14671265
169Left ventricular hypertrophy (HP:0001712)1.14572043
170Abnormality of the ischium (HP:0003174)1.14518006
171Elfin facies (HP:0004428)1.14352716
172Slender build (HP:0001533)1.13003615
173Insomnia (HP:0100785)1.12570059
174Sudden death (HP:0001699)1.12472027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK14.68328876
2ICK2.95394167
3MUSK2.92048189
4IRAK22.82522581
5LATS12.77152518
6MYLK2.59151630
7TTN2.38172483
8TIE12.38144178
9PIK3CG2.35742701
10MAP3K102.34681561
11PRKD32.33461074
12PDK32.14321714
13PDK42.14321714
14PDGFRA2.07860481
15CAMK1G2.06180604
16EPHB21.94149910
17STK391.93515172
18WNK41.84496926
19TYRO31.83920992
20NEK11.69798211
21PINK11.61798425
22PHKG21.60179127
23PHKG11.60179127
24TRIB31.59324275
25EEF2K1.58424654
26PTK2B1.57113461
27CAMK1D1.51849301
28TRPM71.46923266
29MST1R1.44910296
30RIPK11.42946880
31WNK11.41051924
32PDK21.40187740
33MAPKAPK31.38133819
34DMPK1.34779626
35OBSCN1.30523532
36FGFR21.24395048
37PDGFRB1.21290915
38MAP3K71.20323004
39PIK3CA1.17916115
40CCNB11.16331942
41CDK121.13878297
42LMTK21.13864480
43SGK2231.12907420
44SGK4941.12907420
45TGFBR21.10468775
46EPHB11.08382222
47ERBB21.07884999
48DYRK1B1.04157190
49PNCK1.02575552
50MOS1.01214091
51SIK11.00567386
52KDR1.00058305
53NME10.97817263
54PAK20.95218979
55PKN20.94365625
56MAPK150.90822189
57DDR20.89939257
58FER0.89189702
59AKT20.88500996
60PTK60.88476530
61ROCK10.88411281
62TESK10.86577828
63PRKD10.86334359
64PRKCH0.83637963
65STK30.81733740
66PAK30.80461465
67NEK90.80457492
68ADRBK10.78847154
69STK380.78206587
70RET0.78149109
71ERBB30.76689247
72NUAK10.75752286
73PBK0.74518089
74GSK3A0.71004934
75BRD40.67886902
76MAPK120.66729378
77CAMK2G0.66557729
78MET0.66480030
79PRKD20.65616772
80BRSK20.65520377
81BMPR1B0.64376812
82EIF2AK30.63130065
83MTOR0.63114183
84MARK30.63014152
85MAP2K30.61816187
86LIMK10.61622092
87STK38L0.61367658
88TGFBR10.60893205
89PRKAA20.60877197
90MAP2K10.60054305
91CDK90.59898074
92CDC42BPA0.59680227
93PAK60.58520333
94MAP3K40.57970466
95RPS6KB20.57812773
96MAPK70.57496465
97FGFR10.56344811
98PTK20.55584262
99PRKAA10.55542362
100PLK40.54174909
101EPHA30.53111291
102CSNK1D0.52574269
103WEE10.51240332
104INSRR0.49211749
105AKT30.49047407
106PAK40.46099990
107LATS20.45113251
108NEK20.45081116
109OXSR10.44211155
110PKN10.43821494
111ERBB40.43296327
112PRKG10.43199349
113MAPK110.42000141
114MAPK40.41042032
115TLK10.40465090
116ZAK0.40425769
117UHMK10.39913008
118STK160.39607033
119SGK30.39052736
120HIPK20.38876280
121NEK60.38604826
122ILK0.37581338
123PRKACB0.36968966
124CAMK40.36424943
125RPS6KA30.36096542
126RAF10.35699632
127CDK80.35207361
128PDPK10.34134242
129MARK20.33755383
130ROCK20.33738541
131ABL20.33474854
132ARAF0.32715513
133SGK20.32475718
134CAMK2D0.32072723
135GSK3B0.31580324
136AURKB0.30520064
137DYRK1A0.29613609
138MKNK10.29469476
139SRC0.29052425
140WNK30.28297972
141MAPKAPK50.28191792
142IRAK10.28061213
143DAPK30.25410314
144CAMK2A0.25137037
145FRK0.24197129
146RPS6KB10.23393314
147MAP2K40.22985768
148PRKACA0.22622907
149CAMK10.21610334
150NLK0.21521515
151RPS6KA50.21322624
152KSR20.20229147
153MAPK100.19242582
154PAK10.19183023

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002202.39479188
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32320163
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32276308
4Phototransduction_Homo sapiens_hsa0474411.4656085
5Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.99917344
6ECM-receptor interaction_Homo sapiens_hsa045121.85294684
7Carbon metabolism_Homo sapiens_hsa012001.76156049
8Arginine and proline metabolism_Homo sapiens_hsa003301.62771270
9Phenylalanine metabolism_Homo sapiens_hsa003601.60178515
10Dilated cardiomyopathy_Homo sapiens_hsa054141.54582737
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49082207
12Nitrogen metabolism_Homo sapiens_hsa009101.48201988
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41061767
14Biosynthesis of amino acids_Homo sapiens_hsa012301.40434383
15Focal adhesion_Homo sapiens_hsa045101.40297065
16Protein digestion and absorption_Homo sapiens_hsa049741.39772828
17Folate biosynthesis_Homo sapiens_hsa007901.39204196
18cGMP-PKG signaling pathway_Homo sapiens_hsa040221.29576652
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27305819
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26591810
21Pentose phosphate pathway_Homo sapiens_hsa000301.24814778
22Hedgehog signaling pathway_Homo sapiens_hsa043401.24185542
23Axon guidance_Homo sapiens_hsa043601.17617887
24Cardiac muscle contraction_Homo sapiens_hsa042601.13518514
25Tight junction_Homo sapiens_hsa045301.11162700
26Hippo signaling pathway_Homo sapiens_hsa043901.07599813
27Basal cell carcinoma_Homo sapiens_hsa052171.07114758
28Adherens junction_Homo sapiens_hsa045201.06925300
29Cholinergic synapse_Homo sapiens_hsa047251.05780447
30Olfactory transduction_Homo sapiens_hsa047401.04694516
31Fructose and mannose metabolism_Homo sapiens_hsa000511.04619672
32Renin secretion_Homo sapiens_hsa049241.01019287
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97480989
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95966270
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94787161
36Circadian entrainment_Homo sapiens_hsa047130.93980247
37Glucagon signaling pathway_Homo sapiens_hsa049220.93670677
38Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90758524
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90599307
40Circadian rhythm_Homo sapiens_hsa047100.89891059
41Fatty acid biosynthesis_Homo sapiens_hsa000610.89885013
42Renal cell carcinoma_Homo sapiens_hsa052110.89119955
43GABAergic synapse_Homo sapiens_hsa047270.87701120
44Oxytocin signaling pathway_Homo sapiens_hsa049210.86966746
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.86888562
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85681195
47Ovarian steroidogenesis_Homo sapiens_hsa049130.85476371
48beta-Alanine metabolism_Homo sapiens_hsa004100.85128309
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84849012
50Synaptic vesicle cycle_Homo sapiens_hsa047210.82921005
51Notch signaling pathway_Homo sapiens_hsa043300.82698842
52Fatty acid metabolism_Homo sapiens_hsa012120.82619961
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.81458552
54cAMP signaling pathway_Homo sapiens_hsa040240.81125703
55Dorso-ventral axis formation_Homo sapiens_hsa043200.80030500
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78018955
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77799576
58TGF-beta signaling pathway_Homo sapiens_hsa043500.77367800
59Small cell lung cancer_Homo sapiens_hsa052220.76590900
60Viral myocarditis_Homo sapiens_hsa054160.75725260
61Dopaminergic synapse_Homo sapiens_hsa047280.74622225
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73443350
63Wnt signaling pathway_Homo sapiens_hsa043100.73072224
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72930057
65Lysine degradation_Homo sapiens_hsa003100.72767373
66Proteoglycans in cancer_Homo sapiens_hsa052050.71375173
67Purine metabolism_Homo sapiens_hsa002300.71049764
68Fatty acid elongation_Homo sapiens_hsa000620.70649003
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70532453
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.70431347
71Pyruvate metabolism_Homo sapiens_hsa006200.70246685
72Insulin resistance_Homo sapiens_hsa049310.70197401
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69962944
74Glutamatergic synapse_Homo sapiens_hsa047240.69493963
75AMPK signaling pathway_Homo sapiens_hsa041520.69096687
76Insulin secretion_Homo sapiens_hsa049110.68940425
77Tyrosine metabolism_Homo sapiens_hsa003500.68010684
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67954353
79Amoebiasis_Homo sapiens_hsa051460.66851416
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66514857
81Alzheimers disease_Homo sapiens_hsa050100.65611432
82Starch and sucrose metabolism_Homo sapiens_hsa005000.65282014
83Propanoate metabolism_Homo sapiens_hsa006400.64481103
84Gastric acid secretion_Homo sapiens_hsa049710.63019143
85Parkinsons disease_Homo sapiens_hsa050120.61865717
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.61405566
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60860250
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60432790
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58785361
90Morphine addiction_Homo sapiens_hsa050320.57391503
91Pathways in cancer_Homo sapiens_hsa052000.57049545
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56845178
93Ras signaling pathway_Homo sapiens_hsa040140.56792361
94Endometrial cancer_Homo sapiens_hsa052130.56225511
95Butanoate metabolism_Homo sapiens_hsa006500.56026903
96Sulfur relay system_Homo sapiens_hsa041220.55962391
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55781204
98mTOR signaling pathway_Homo sapiens_hsa041500.55678277
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.54675689
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.54425952
101Prostate cancer_Homo sapiens_hsa052150.54018571
102Melanogenesis_Homo sapiens_hsa049160.53657218
103Fatty acid degradation_Homo sapiens_hsa000710.53153044
104Estrogen signaling pathway_Homo sapiens_hsa049150.52701778
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52467147
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52031466
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50383325
108VEGF signaling pathway_Homo sapiens_hsa043700.50147205
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49459419
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48578300
111Retinol metabolism_Homo sapiens_hsa008300.48388831
112Thyroid cancer_Homo sapiens_hsa052160.48324835
113Tryptophan metabolism_Homo sapiens_hsa003800.48026801
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47485417
115Glioma_Homo sapiens_hsa052140.47098584
116HIF-1 signaling pathway_Homo sapiens_hsa040660.46481319
117Thyroid hormone synthesis_Homo sapiens_hsa049180.45862493
118PPAR signaling pathway_Homo sapiens_hsa033200.45230559
119Histidine metabolism_Homo sapiens_hsa003400.45137044
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44682464
121Serotonergic synapse_Homo sapiens_hsa047260.44344383
122Glycerolipid metabolism_Homo sapiens_hsa005610.43649118
123Galactose metabolism_Homo sapiens_hsa000520.43345148
124Type II diabetes mellitus_Homo sapiens_hsa049300.43035527
125FoxO signaling pathway_Homo sapiens_hsa040680.42976518
126Choline metabolism in cancer_Homo sapiens_hsa052310.41543726
127Selenocompound metabolism_Homo sapiens_hsa004500.40705321
128Glutathione metabolism_Homo sapiens_hsa004800.39966865
129Gap junction_Homo sapiens_hsa045400.39535144
130Pancreatic secretion_Homo sapiens_hsa049720.39345749
131Oocyte meiosis_Homo sapiens_hsa041140.38225368
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38212802
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37947222
134Calcium signaling pathway_Homo sapiens_hsa040200.37743487
135Insulin signaling pathway_Homo sapiens_hsa049100.37498071
136Salivary secretion_Homo sapiens_hsa049700.36904697
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36842210
138Endocytosis_Homo sapiens_hsa041440.36746260
139Alcoholism_Homo sapiens_hsa050340.36535255
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32529923
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29681086
142Nucleotide excision repair_Homo sapiens_hsa034200.28503542
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26394231

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