EGFEM1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aggressive behavior (GO:0002118)5.07999245
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.52984364
3epithelial cilium movement (GO:0003351)4.36653005
4axoneme assembly (GO:0035082)4.28754241
5cilium movement (GO:0003341)3.97530886
6intraciliary transport (GO:0042073)3.92712002
7protein polyglutamylation (GO:0018095)3.83419262
8inositol phosphate catabolic process (GO:0071545)3.69245575
9regulation of cilium movement (GO:0003352)3.68395704
10behavioral response to nicotine (GO:0035095)3.66411215
11photoreceptor cell maintenance (GO:0045494)3.65932011
12retinal cone cell development (GO:0046549)3.65332006
13seminiferous tubule development (GO:0072520)3.63434542
14pyrimidine nucleobase catabolic process (GO:0006208)3.63296569
15nonmotile primary cilium assembly (GO:0035058)3.63138664
16phosphorylated carbohydrate dephosphorylation (GO:0046838)3.56892358
17inositol phosphate dephosphorylation (GO:0046855)3.56892358
18cilium or flagellum-dependent cell motility (GO:0001539)3.56296021
19respiratory chain complex IV assembly (GO:0008535)3.44666210
20cellular ketone body metabolic process (GO:0046950)3.40011197
21cytochrome complex assembly (GO:0017004)3.39134589
22retinal ganglion cell axon guidance (GO:0031290)3.38781544
23parental behavior (GO:0060746)3.37005767
24protein complex biogenesis (GO:0070271)3.36366364
25protein localization to cilium (GO:0061512)3.33082130
26preassembly of GPI anchor in ER membrane (GO:0016254)3.30791144
27maternal behavior (GO:0042711)3.30368550
28nucleobase catabolic process (GO:0046113)3.30203655
29behavioral response to ethanol (GO:0048149)3.29190049
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19993733
31response to pheromone (GO:0019236)3.15336058
32cilium organization (GO:0044782)3.08466047
33presynaptic membrane organization (GO:0097090)3.04804719
34cilium morphogenesis (GO:0060271)3.04799875
35retinal rod cell development (GO:0046548)3.02808957
36kidney morphogenesis (GO:0060993)3.02671588
37ketone body metabolic process (GO:1902224)3.01222884
38mitochondrial respiratory chain complex assembly (GO:0033108)3.00232924
39cilium assembly (GO:0042384)2.96529876
40interkinetic nuclear migration (GO:0022027)2.94207000
41estrogen biosynthetic process (GO:0006703)2.86829265
42neuronal action potential (GO:0019228)2.84723890
43presynaptic membrane assembly (GO:0097105)2.84264158
44positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.82648610
45water-soluble vitamin biosynthetic process (GO:0042364)2.82391723
46GPI anchor metabolic process (GO:0006505)2.81107407
47axonemal dynein complex assembly (GO:0070286)2.78716898
48positive regulation of histone H3-K4 methylation (GO:0051571)2.78347355
49polyol catabolic process (GO:0046174)2.75600606
50dendritic spine morphogenesis (GO:0060997)2.72177831
51regulation of female receptivity (GO:0045924)2.71557421
52nephron epithelium morphogenesis (GO:0072088)2.69849023
53nephron tubule morphogenesis (GO:0072078)2.69849023
54neural tube formation (GO:0001841)2.67050689
55positive regulation of amino acid transport (GO:0051957)2.66407150
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66260902
57mitochondrial respiratory chain complex I assembly (GO:0032981)2.66260902
58NADH dehydrogenase complex assembly (GO:0010257)2.66260902
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64879879
60dentate gyrus development (GO:0021542)2.64072958
61brain morphogenesis (GO:0048854)2.63331790
62indolalkylamine metabolic process (GO:0006586)2.63303564
63fucose catabolic process (GO:0019317)2.62616312
64L-fucose metabolic process (GO:0042354)2.62616312
65L-fucose catabolic process (GO:0042355)2.62616312
66positive regulation of meiosis (GO:0045836)2.60774497
67branched-chain amino acid catabolic process (GO:0009083)2.59452765
68pancreas development (GO:0031016)2.55937490
69positive regulation of prostaglandin secretion (GO:0032308)2.53870829
70indole-containing compound catabolic process (GO:0042436)2.53029080
71indolalkylamine catabolic process (GO:0046218)2.53029080
72tryptophan catabolic process (GO:0006569)2.53029080
73positive regulation of amine transport (GO:0051954)2.52835869
74C-terminal protein lipidation (GO:0006501)2.52419572
75photoreceptor cell development (GO:0042461)2.52331627
76cell wall macromolecule catabolic process (GO:0016998)2.51665873
77L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51101428
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50731110
79glycerophospholipid catabolic process (GO:0046475)2.48819042
80S-adenosylmethionine metabolic process (GO:0046500)2.48157679
81regulation of neurotransmitter uptake (GO:0051580)2.45581034
82mannosylation (GO:0097502)2.45473327
83auditory receptor cell differentiation (GO:0042491)2.45221776
84regulation of glucokinase activity (GO:0033131)2.43764793
85regulation of hexokinase activity (GO:1903299)2.43764793
86platelet dense granule organization (GO:0060155)2.43527455
87cellular component assembly involved in morphogenesis (GO:0010927)2.40361395
88positive regulation of meiotic cell cycle (GO:0051446)2.39995101
89detection of light stimulus involved in sensory perception (GO:0050962)2.39165357
90detection of light stimulus involved in visual perception (GO:0050908)2.39165357
91nitric oxide mediated signal transduction (GO:0007263)2.38202699
92determination of left/right symmetry (GO:0007368)2.37871576
93response to nitrosative stress (GO:0051409)2.37180647
94positive regulation of organic acid transport (GO:0032892)2.37091315
95renal tubule morphogenesis (GO:0061333)2.34471497
96GPI anchor biosynthetic process (GO:0006506)2.33549672
97inner ear receptor stereocilium organization (GO:0060122)2.33416003
98signal peptide processing (GO:0006465)2.32238290
99axonal fasciculation (GO:0007413)2.31198183
100valine metabolic process (GO:0006573)2.30619551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.49901437
2ZNF274_21170338_ChIP-Seq_K562_Hela3.29698966
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.96744869
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79120585
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64360821
6VDR_22108803_ChIP-Seq_LS180_Human2.64136812
7FUS_26573619_Chip-Seq_HEK293_Human2.63403549
8IGF1R_20145208_ChIP-Seq_DFB_Human2.61585316
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61523840
10EZH2_22144423_ChIP-Seq_EOC_Human2.59541949
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48268873
12TAF15_26573619_Chip-Seq_HEK293_Human2.41884541
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27808200
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23787891
15EWS_26573619_Chip-Seq_HEK293_Human2.16423596
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10151700
17P300_19829295_ChIP-Seq_ESCs_Human2.07901286
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06054791
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.05089642
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.84553535
21SMAD4_21799915_ChIP-Seq_A2780_Human1.84429505
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82434016
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79940743
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.77078425
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.76169739
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74358986
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74066911
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72506644
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67249089
30RNF2_27304074_Chip-Seq_NSC_Mouse1.64223043
31BCAT_22108803_ChIP-Seq_LS180_Human1.63840602
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62892795
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61719668
34ER_23166858_ChIP-Seq_MCF-7_Human1.58454324
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56216112
36STAT3_23295773_ChIP-Seq_U87_Human1.54759265
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53967962
38REST_21632747_ChIP-Seq_MESCs_Mouse1.51949098
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49786677
40AR_25329375_ChIP-Seq_VCAP_Human1.48097833
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47674355
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46687952
43TP53_22573176_ChIP-Seq_HFKS_Human1.46599512
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.45494645
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42939600
46CBP_20019798_ChIP-Seq_JUKART_Human1.42403713
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42403713
48TCF4_23295773_ChIP-Seq_U87_Human1.41733046
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39833664
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39695972
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39124619
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37983821
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35814975
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35264509
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33025115
56TCF4_22108803_ChIP-Seq_LS180_Human1.32484801
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.31943319
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30482710
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.29946115
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.27275289
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.27005923
62SOX2_19829295_ChIP-Seq_ESCs_Human1.26992345
63NANOG_19829295_ChIP-Seq_ESCs_Human1.26992345
64RUNX2_22187159_ChIP-Seq_PCA_Human1.22256805
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21984170
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21081004
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21081004
68P53_22387025_ChIP-Seq_ESCs_Mouse1.20919210
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20754577
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20492061
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18495345
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17488384
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.17177357
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16159409
75IRF1_19129219_ChIP-ChIP_H3396_Human1.13235093
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11892473
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10964888
78MYC_18940864_ChIP-ChIP_HL60_Human1.09844018
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.09486121
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09244962
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.09133735
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09024771
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08969749
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.08969749
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08877887
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08572073
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.05122878
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04826761
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.04607515
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.03178042
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.02172732
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00858285
93P300_18555785_Chip-Seq_ESCs_Mouse0.99909670
94CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99731863
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99417381
96AR_20517297_ChIP-Seq_VCAP_Human0.99046204
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.96288127
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95614353
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.95380568
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95317888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.27191034
2MP0002837_dystrophic_cardiac_calcinosis2.94734834
3MP0006072_abnormal_retinal_apoptosis2.77473759
4MP0005645_abnormal_hypothalamus_physiol2.71107117
5MP0005646_abnormal_pituitary_gland2.53629157
6MP0003880_abnormal_central_pattern2.52463527
7MP0006292_abnormal_olfactory_placode2.46059565
8MP0005551_abnormal_eye_electrophysiolog2.45165110
9MP0008877_abnormal_DNA_methylation2.45110206
10MP0005379_endocrine/exocrine_gland_phen2.38858589
11MP0005253_abnormal_eye_physiology2.21702420
12MP0002102_abnormal_ear_morphology2.11511574
13MP0003122_maternal_imprinting2.04444174
14MP0000631_abnormal_neuroendocrine_gland2.02654642
15MP0004133_heterotaxia1.96327661
16MP0005084_abnormal_gallbladder_morpholo1.92689023
17MP0001984_abnormal_olfaction1.90831912
18MP0001968_abnormal_touch/_nociception1.90452659
19MP0002638_abnormal_pupillary_reflex1.88441202
20MP0006276_abnormal_autonomic_nervous1.83779747
21MP0002938_white_spotting1.79491943
22MP0003121_genomic_imprinting1.76688643
23MP0002822_catalepsy1.76481675
24MP0002163_abnormal_gland_morphology1.72507722
25MP0009046_muscle_twitch1.69783271
26MP0000372_irregular_coat_pigmentation1.64260048
27MP0001529_abnormal_vocalization1.63192028
28MP0004145_abnormal_muscle_electrophysio1.58588512
29MP0002928_abnormal_bile_duct1.56480963
30MP0003011_delayed_dark_adaptation1.56240015
31MP0005423_abnormal_somatic_nervous1.54860798
32MP0002909_abnormal_adrenal_gland1.53798098
33MP0002557_abnormal_social/conspecific_i1.52099244
34MP0002272_abnormal_nervous_system1.51765601
35MP0009745_abnormal_behavioral_response1.50990318
36MP0002572_abnormal_emotion/affect_behav1.48808515
37MP0004885_abnormal_endolymph1.46414015
38MP0001486_abnormal_startle_reflex1.44046332
39MP0004270_analgesia1.43655034
40MP0002736_abnormal_nociception_after1.43602211
41MP0001501_abnormal_sleep_pattern1.42372307
42MP0004142_abnormal_muscle_tone1.37189225
43MP0000383_abnormal_hair_follicle1.34125158
44MP0002735_abnormal_chemical_nociception1.32514349
45MP0002734_abnormal_mechanical_nocicepti1.31749715
46MP0000569_abnormal_digit_pigmentation1.31139197
47MP0001970_abnormal_pain_threshold1.23414940
48MP0008058_abnormal_DNA_repair1.23008109
49MP0005367_renal/urinary_system_phenotyp1.21277940
50MP0000516_abnormal_urinary_system1.21277940
51MP0002234_abnormal_pharynx_morphology1.21147517
52MP0000427_abnormal_hair_cycle1.20913574
53MP0005248_abnormal_Harderian_gland1.20844454
54MP0005195_abnormal_posterior_eye1.16500514
55MP0000778_abnormal_nervous_system1.16259061
56MP0004043_abnormal_pH_regulation1.13210152
57MP0002064_seizures1.11985854
58MP0001944_abnormal_pancreas_morphology1.10607451
59MP0002063_abnormal_learning/memory/cond1.07510755
60MP0005174_abnormal_tail_pigmentation1.07316276
61MP0002876_abnormal_thyroid_physiology1.06043130
62MP0005386_behavior/neurological_phenoty1.05711021
63MP0004924_abnormal_behavior1.05711021
64MP0003195_calcinosis1.03488293
65MP0008789_abnormal_olfactory_epithelium1.03293478
66MP0001188_hyperpigmentation1.03051690
67MP0002693_abnormal_pancreas_physiology1.01796579
68MP0002653_abnormal_ependyma_morphology1.01765446
69MP0002184_abnormal_innervation1.01548331
70MP0001905_abnormal_dopamine_level1.00418856
71MP0005220_abnormal_exocrine_pancreas0.99558755
72MP0002733_abnormal_thermal_nociception0.98898377
73MP0001986_abnormal_taste_sensitivity0.97837385
74MP0003635_abnormal_synaptic_transmissio0.96717119
75MP0008875_abnormal_xenobiotic_pharmacok0.96637644
76MP0008872_abnormal_physiological_respon0.96003184
77MP0010386_abnormal_urinary_bladder0.94532775
78MP0002067_abnormal_sensory_capabilities0.93278795
79MP0004742_abnormal_vestibular_system0.92841783
80MP0005391_vision/eye_phenotype0.92317009
81MP0004215_abnormal_myocardial_fiber0.91620455
82MP0000013_abnormal_adipose_tissue0.90494166
83MP0010678_abnormal_skin_adnexa0.90230344
84MP0003136_yellow_coat_color0.90229100
85MP0002752_abnormal_somatic_nervous0.88797379
86MP0003718_maternal_effect0.87342229
87MP0002229_neurodegeneration0.87122823
88MP0003633_abnormal_nervous_system0.86606173
89MP0002095_abnormal_skin_pigmentation0.86294084
90MP0002160_abnormal_reproductive_system0.84831842
91MP0001485_abnormal_pinna_reflex0.84478616
92MP0005499_abnormal_olfactory_system0.83922207
93MP0005394_taste/olfaction_phenotype0.83922207
94MP0005389_reproductive_system_phenotype0.83811864
95MP0000566_synostosis0.80853581
96MP0003137_abnormal_impulse_conducting0.80641152
97MP0002882_abnormal_neuron_morphology0.80062973
98MP0000647_abnormal_sebaceous_gland0.77562610
99MP0001324_abnormal_eye_pigmentation0.76847745
100MP0001963_abnormal_hearing_physiology0.76425681

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)4.00886778
2Pancreatic fibrosis (HP:0100732)3.72364874
3Molar tooth sign on MRI (HP:0002419)3.62307514
4Abnormality of midbrain morphology (HP:0002418)3.62307514
5Pancreatic cysts (HP:0001737)3.60980795
6True hermaphroditism (HP:0010459)3.47786998
7Nephronophthisis (HP:0000090)3.47245634
8Abnormal rod and cone electroretinograms (HP:0008323)3.44150319
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.33672691
10Gait imbalance (HP:0002141)3.28900055
11Absent/shortened dynein arms (HP:0200106)3.22012118
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.22012118
13Congenital primary aphakia (HP:0007707)3.20685271
14Abnormality of the renal medulla (HP:0100957)3.10492708
15Abnormal respiratory motile cilium morphology (HP:0005938)3.00204932
16Abnormal respiratory epithelium morphology (HP:0012253)3.00204932
17Nephrogenic diabetes insipidus (HP:0009806)2.96827340
18Type II lissencephaly (HP:0007260)2.95472704
19Intestinal atresia (HP:0011100)2.94230237
20Abnormal ciliary motility (HP:0012262)2.93868420
21Tubulointerstitial nephritis (HP:0001970)2.92766697
22Attenuation of retinal blood vessels (HP:0007843)2.89870104
23Abnormality of the renal cortex (HP:0011035)2.88444170
24Genital tract atresia (HP:0001827)2.86575764
25Congenital stationary night blindness (HP:0007642)2.79352799
26Vaginal atresia (HP:0000148)2.78999993
27Chronic hepatic failure (HP:0100626)2.75030159
28Decreased circulating renin level (HP:0003351)2.72783445
29Abolished electroretinogram (ERG) (HP:0000550)2.70241388
30Hemiparesis (HP:0001269)2.57917014
31Pendular nystagmus (HP:0012043)2.56380346
32Double outlet right ventricle (HP:0001719)2.50371070
33Congenital malformation of the right heart (HP:0011723)2.50371070
34Hypothermia (HP:0002045)2.45184197
35Methylmalonic acidemia (HP:0002912)2.43816732
36Abnormal respiratory motile cilium physiology (HP:0012261)2.43239231
37Acute necrotizing encephalopathy (HP:0006965)2.43144196
38Cystic liver disease (HP:0006706)2.42924897
39Renal cortical cysts (HP:0000803)2.42673562
40Bony spicule pigmentary retinopathy (HP:0007737)2.39399595
41Mitochondrial inheritance (HP:0001427)2.35958524
42Cerebellar dysplasia (HP:0007033)2.35397895
43Decreased central vision (HP:0007663)2.33985411
44Progressive macrocephaly (HP:0004481)2.29756756
45Hyperventilation (HP:0002883)2.25961504
46Lissencephaly (HP:0001339)2.25563598
47Hyperglycinemia (HP:0002154)2.25143458
48Febrile seizures (HP:0002373)2.21423586
49Polydipsia (HP:0001959)2.14206807
50Abnormal drinking behavior (HP:0030082)2.14206807
51Abnormality of vitamin B metabolism (HP:0004340)2.12512450
52Methylmalonic aciduria (HP:0012120)2.11707088
53Congenital hepatic fibrosis (HP:0002612)2.08541854
54Increased CSF lactate (HP:0002490)2.08525126
553-Methylglutaconic aciduria (HP:0003535)2.08401142
56Ketoacidosis (HP:0001993)2.07759885
57Poor coordination (HP:0002370)2.07752644
58Keratoconus (HP:0000563)2.05473567
59Increased corneal curvature (HP:0100692)2.05473567
60Tubular atrophy (HP:0000092)2.05303325
61Gaze-evoked nystagmus (HP:0000640)2.02838972
62Acute encephalopathy (HP:0006846)2.01735459
63Abnormal mitochondria in muscle tissue (HP:0008316)2.00909699
64Colon cancer (HP:0003003)2.00369974
65Hepatocellular necrosis (HP:0001404)1.99162282
66Postaxial hand polydactyly (HP:0001162)1.99076168
67Hyperkalemia (HP:0002153)1.97122905
68Anencephaly (HP:0002323)1.96927197
69Focal motor seizures (HP:0011153)1.94439795
70Lipid accumulation in hepatocytes (HP:0006561)1.91850878
71Oligodactyly (hands) (HP:0001180)1.91124562
72Ketosis (HP:0001946)1.90988335
73Bile duct proliferation (HP:0001408)1.90239785
74Abnormal biliary tract physiology (HP:0012439)1.90239785
75Aplasia/Hypoplasia of the tibia (HP:0005772)1.90157793
76Increased hepatocellular lipid droplets (HP:0006565)1.89029021
77Optic disc pallor (HP:0000543)1.87815013
78Tubulointerstitial abnormality (HP:0001969)1.87252292
79Progressive cerebellar ataxia (HP:0002073)1.87213464
80Polyphagia (HP:0002591)1.86914911
81Postaxial foot polydactyly (HP:0001830)1.86332768
82Hepatic necrosis (HP:0002605)1.85919709
83Hyperglycinuria (HP:0003108)1.85717896
84Abnormality of the labia minora (HP:0012880)1.85020161
85Neoplasm of the adrenal cortex (HP:0100641)1.83992803
86Retinitis pigmentosa (HP:0000510)1.82604088
87Concave nail (HP:0001598)1.82490507
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.80664837
89Agitation (HP:0000713)1.80627299
90Abdominal situs inversus (HP:0003363)1.80178098
91Abnormality of abdominal situs (HP:0011620)1.80178098
92Limb dystonia (HP:0002451)1.79361234
93Male pseudohermaphroditism (HP:0000037)1.78615346
94Sclerocornea (HP:0000647)1.77789764
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76038120
96Large for gestational age (HP:0001520)1.75086762
97Renal Fanconi syndrome (HP:0001994)1.74410605
98Optic nerve hypoplasia (HP:0000609)1.73766533
99Retinal dysplasia (HP:0007973)1.73203214
100Rhinitis (HP:0012384)1.70632460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.18321554
2MAP4K23.40254431
3WNK33.13340455
4CASK2.95031653
5MAP3K42.85509231
6PINK12.59239936
7ZAK2.45589913
8TAOK32.40846236
9NUAK12.39950412
10TNIK2.34485791
11BCKDK2.32996517
12BMPR1B2.07447870
13MAPK132.06404364
14GRK12.05049761
15ADRBK21.98914359
16MARK11.86254708
17INSRR1.85119122
18MAP2K71.85112633
19FGFR21.74090441
20PNCK1.63206479
21BRSK21.45237570
22DAPK21.41850128
23FLT31.36335349
24MKNK21.29849318
25TIE11.26049572
26MAP2K61.24633046
27WNK41.24126129
28CSNK1G21.22298871
29DYRK21.21865185
30ACVR1B1.17532413
31PHKG21.13398991
32PHKG11.13398991
33STK38L1.11110916
34TLK11.10427858
35OBSCN1.08756248
36CSNK1G11.07562799
37PAK31.02196877
38CSNK1G31.00756080
39PRKCG1.00054308
40PRKCE0.98137764
41NTRK30.96725057
42BCR0.95491861
43EPHA30.91288887
44VRK10.88679574
45EPHA40.87275672
46WEE10.87228201
47CSNK1A1L0.84841864
48VRK20.84432537
49MKNK10.81450128
50STK390.78183187
51UHMK10.74917288
52MAP2K40.72599838
53OXSR10.71466183
54ERBB30.70856226
55PLK20.69174934
56STK240.68126465
57NTRK20.67095403
58NLK0.62795206
59ADRBK10.61742850
60CAMK2A0.61250451
61TRIM280.59513572
62MAPK150.58249094
63PRKCQ0.57606274
64MAP3K70.57456817
65AKT30.57296666
66DYRK1A0.56754215
67CAMK10.56057992
68PRKACA0.55321348
69PKN10.54327647
70STK30.52950577
71CAMK2D0.51294767
72PLK30.49993366
73RPS6KA50.48803230
74DYRK30.48585873
75FER0.47861212
76CSNK1A10.45852575
77TNK20.45721085
78KIT0.44833141
79STK110.43501271
80CDK30.43495977
81TGFBR10.40913118
82GRK70.40667931
83TEC0.39701379
84MINK10.39478127
85PRKG10.38832975
86MST40.38122301
87PRKACB0.37905972
88PRKAA10.37591347
89ATM0.36864845
90SGK20.36217372
91PIK3CA0.35506160
92PRKCA0.34876643
93CSNK1D0.34771093
94TXK0.34645905
95PLK10.33888228
96CDK50.33516902
97PTK2B0.32288608
98PLK40.32067370
99TAF10.31315673
100MAPKAPK50.30660707

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.35770079
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.28756672
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.98718733
4Oxidative phosphorylation_Homo sapiens_hsa001902.58309647
5Butanoate metabolism_Homo sapiens_hsa006502.58116524
6Phototransduction_Homo sapiens_hsa047442.41871458
7Protein export_Homo sapiens_hsa030602.17352736
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16368468
9Propanoate metabolism_Homo sapiens_hsa006402.01484692
10Parkinsons disease_Homo sapiens_hsa050121.88416056
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84112554
12Nicotine addiction_Homo sapiens_hsa050331.83690831
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82972327
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80361515
15Selenocompound metabolism_Homo sapiens_hsa004501.78491332
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72436162
17Taste transduction_Homo sapiens_hsa047421.69689126
18Linoleic acid metabolism_Homo sapiens_hsa005911.68620413
19Peroxisome_Homo sapiens_hsa041461.57321137
20Tryptophan metabolism_Homo sapiens_hsa003801.56790242
21Insulin secretion_Homo sapiens_hsa049111.55462768
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50495718
23Circadian entrainment_Homo sapiens_hsa047131.49314925
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48152508
25Ether lipid metabolism_Homo sapiens_hsa005651.47677315
26Cardiac muscle contraction_Homo sapiens_hsa042601.45733669
27Nitrogen metabolism_Homo sapiens_hsa009101.41499946
28Huntingtons disease_Homo sapiens_hsa050161.33519369
29Collecting duct acid secretion_Homo sapiens_hsa049661.32330538
30Olfactory transduction_Homo sapiens_hsa047401.26431665
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21940797
32Alzheimers disease_Homo sapiens_hsa050101.21807734
33Regulation of autophagy_Homo sapiens_hsa041401.19316407
34Morphine addiction_Homo sapiens_hsa050321.18697676
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17536933
36Homologous recombination_Homo sapiens_hsa034401.13763633
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12568549
38Basal transcription factors_Homo sapiens_hsa030221.11966774
39Serotonergic synapse_Homo sapiens_hsa047261.10979868
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08913644
41Glutamatergic synapse_Homo sapiens_hsa047241.08073997
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.07600524
43Fanconi anemia pathway_Homo sapiens_hsa034601.05299193
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.00760601
45Sulfur metabolism_Homo sapiens_hsa009200.99049295
46Arachidonic acid metabolism_Homo sapiens_hsa005900.98855129
47Salivary secretion_Homo sapiens_hsa049700.98781640
48Dopaminergic synapse_Homo sapiens_hsa047280.98574833
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98420796
50GABAergic synapse_Homo sapiens_hsa047270.98264489
51Fatty acid elongation_Homo sapiens_hsa000620.97461439
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97418441
53ABC transporters_Homo sapiens_hsa020100.97098731
54Chemical carcinogenesis_Homo sapiens_hsa052040.96910462
55Type I diabetes mellitus_Homo sapiens_hsa049400.95437233
56RNA degradation_Homo sapiens_hsa030180.95133030
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91304790
58Retinol metabolism_Homo sapiens_hsa008300.90160617
59Renin secretion_Homo sapiens_hsa049240.89713755
60Long-term depression_Homo sapiens_hsa047300.88680754
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87803554
62beta-Alanine metabolism_Homo sapiens_hsa004100.87214441
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86757455
64Non-homologous end-joining_Homo sapiens_hsa034500.86664707
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84987357
66Steroid biosynthesis_Homo sapiens_hsa001000.80516648
67RNA polymerase_Homo sapiens_hsa030200.78079681
68Metabolic pathways_Homo sapiens_hsa011000.77170961
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76379492
70Purine metabolism_Homo sapiens_hsa002300.76315338
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73655335
72Amphetamine addiction_Homo sapiens_hsa050310.71561445
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70571241
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.69392837
75Cocaine addiction_Homo sapiens_hsa050300.68955754
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68117053
77Calcium signaling pathway_Homo sapiens_hsa040200.68064531
78Circadian rhythm_Homo sapiens_hsa047100.67804422
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64938560
80Glutathione metabolism_Homo sapiens_hsa004800.62269786
81Folate biosynthesis_Homo sapiens_hsa007900.56794964
82Ovarian steroidogenesis_Homo sapiens_hsa049130.53182688
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51496394
84Glycerolipid metabolism_Homo sapiens_hsa005610.51071578
85Basal cell carcinoma_Homo sapiens_hsa052170.49068361
86Oxytocin signaling pathway_Homo sapiens_hsa049210.48582455
87cAMP signaling pathway_Homo sapiens_hsa040240.44678497
88Fatty acid metabolism_Homo sapiens_hsa012120.40344582
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.38611089
90Caffeine metabolism_Homo sapiens_hsa002320.38463677
91Mineral absorption_Homo sapiens_hsa049780.38402050
92Synaptic vesicle cycle_Homo sapiens_hsa047210.38080057
93One carbon pool by folate_Homo sapiens_hsa006700.37828161
94Cholinergic synapse_Homo sapiens_hsa047250.37092355
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35166805
96Asthma_Homo sapiens_hsa053100.34379301
97Fatty acid degradation_Homo sapiens_hsa000710.34040599
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.31902040
99Hedgehog signaling pathway_Homo sapiens_hsa043400.31633343
100Histidine metabolism_Homo sapiens_hsa003400.29993070

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »