EGF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.17583704
2drug transmembrane transport (GO:0006855)9.16671863
3urate metabolic process (GO:0046415)9.03616494
4actin filament depolymerization (GO:0030042)8.27735841
5lysine metabolic process (GO:0006553)8.16755326
6lysine catabolic process (GO:0006554)8.16755326
7drug transport (GO:0015893)7.73868534
8organic cation transport (GO:0015695)7.56986284
9phosphate ion transport (GO:0006817)7.14679327
10collecting duct development (GO:0072044)7.04586877
11excretion (GO:0007588)6.74252373
12cardiovascular system development (GO:0072358)6.74023021
13valine metabolic process (GO:0006573)6.58436777
14response to mercury ion (GO:0046689)6.31952771
15quaternary ammonium group transport (GO:0015697)6.28007060
16renal absorption (GO:0070293)6.26609685
17phosphate ion transmembrane transport (GO:0035435)5.93705403
18branched-chain amino acid metabolic process (GO:0009081)5.82722539
19metanephric nephron tubule development (GO:0072234)5.74209424
20metanephric tubule development (GO:0072170)5.74209424
21response to water (GO:0009415)5.70196443
22tricarboxylic acid metabolic process (GO:0072350)5.65198675
23cysteine metabolic process (GO:0006534)5.64430914
24short-chain fatty acid metabolic process (GO:0046459)5.53147895
252-oxoglutarate metabolic process (GO:0006103)5.41270398
26aspartate family amino acid catabolic process (GO:0009068)5.39469293
27metanephric nephron epithelium development (GO:0072243)5.26782235
28toxin transport (GO:1901998)5.20230285
29glyoxylate metabolic process (GO:0046487)5.15721121
30cell volume homeostasis (GO:0006884)5.08076749
31response to lead ion (GO:0010288)5.06830837
32homocysteine metabolic process (GO:0050667)5.04705250
33response to thyroid hormone (GO:0097066)5.00651461
34muscle filament sliding (GO:0030049)4.98389852
35actin-myosin filament sliding (GO:0033275)4.98389852
36metanephric epithelium development (GO:0072207)4.97410545
37branched-chain amino acid catabolic process (GO:0009083)4.96486909
38response to magnesium ion (GO:0032026)4.95503449
39drug catabolic process (GO:0042737)4.85665322
40cellular modified amino acid catabolic process (GO:0042219)4.84471136
41sarcoplasmic reticulum calcium ion transport (GO:0070296)4.72464682
42polyol transport (GO:0015791)4.71452854
43vitamin D metabolic process (GO:0042359)4.70364437
44glycoside metabolic process (GO:0016137)4.67425680
45amino-acid betaine transport (GO:0015838)4.64709472
46carnitine transport (GO:0015879)4.64709472
47proline metabolic process (GO:0006560)4.62772686
48nonribosomal peptide biosynthetic process (GO:0019184)4.55380046
49mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.47747990
50inositol metabolic process (GO:0006020)4.46682280
51exogenous drug catabolic process (GO:0042738)4.45282986
52modified amino acid transport (GO:0072337)4.38089978
53trivalent inorganic anion homeostasis (GO:0072506)4.28336523
54phosphate ion homeostasis (GO:0055062)4.28336523
55actin-mediated cell contraction (GO:0070252)4.26950822
56peptide catabolic process (GO:0043171)4.26390838
57regulation of skeletal muscle contraction (GO:0014819)4.24369978
58tryptophan catabolic process (GO:0006569)4.24187776
59indole-containing compound catabolic process (GO:0042436)4.24187776
60indolalkylamine catabolic process (GO:0046218)4.24187776
61nephron tubule development (GO:0072080)4.22736014
62aromatic amino acid family catabolic process (GO:0009074)4.10854612
63tryptophan metabolic process (GO:0006568)4.10324885
64fatty acid beta-oxidation (GO:0006635)4.07199464
65glutathione biosynthetic process (GO:0006750)4.05385254
66regulation of potassium ion transmembrane transporter activity (GO:1901016)4.04564885
67fructose metabolic process (GO:0006000)3.99247341
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.97958886
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.96388061
70L-phenylalanine metabolic process (GO:0006558)3.96388061
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.91654191
72L-phenylalanine catabolic process (GO:0006559)3.91654191
73nephron tubule formation (GO:0072079)3.91371315
74biotin metabolic process (GO:0006768)3.90996632
75acetyl-CoA metabolic process (GO:0006084)3.90106303
76negative regulation of protein localization to cell surface (GO:2000009)3.89831161
77serine family amino acid catabolic process (GO:0009071)3.86656784
78fatty acid oxidation (GO:0019395)3.86140013
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.84224879
80creatine metabolic process (GO:0006600)3.84139316
81amino-acid betaine metabolic process (GO:0006577)3.81241607
82lipid oxidation (GO:0034440)3.78657706
83hyperosmotic response (GO:0006972)3.75961444
84renal tubule development (GO:0061326)3.74467620
85response to phenylpropanoid (GO:0080184)3.72068151
86oxaloacetate metabolic process (GO:0006107)3.69559242
87response to copper ion (GO:0046688)3.67529713
88regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.67201300
89blood coagulation, intrinsic pathway (GO:0007597)3.65797320
90serine family amino acid metabolic process (GO:0009069)3.65654235
91NADH metabolic process (GO:0006734)3.59958151
92sulfur compound transport (GO:0072348)3.55938850
93glutamate metabolic process (GO:0006536)3.54646099
94cellular amino acid catabolic process (GO:0009063)3.53607599
95pyrimidine ribonucleoside catabolic process (GO:0046133)3.53604371
96sulfur amino acid catabolic process (GO:0000098)3.50423031
97vitamin transport (GO:0051180)3.49997989
98cellular ketone body metabolic process (GO:0046950)3.49803085
99kynurenine metabolic process (GO:0070189)3.49601078
100carnitine metabolic process (GO:0009437)3.49590377
101negative regulation of metanephros development (GO:0072217)3.48671652
102nephron epithelium development (GO:0072009)3.47786969
103bone remodeling (GO:0046849)3.45171730
104succinate metabolic process (GO:0006105)3.43886049
105beta-amyloid metabolic process (GO:0050435)3.43645616
106oligosaccharide catabolic process (GO:0009313)3.40354634
107regulation of relaxation of muscle (GO:1901077)3.40161183
108vitamin transmembrane transport (GO:0035461)3.35226580
109fatty acid catabolic process (GO:0009062)3.33807729
110thrombin receptor signaling pathway (GO:0070493)3.31579741
111peptide biosynthetic process (GO:0043043)3.30660788
112skeletal muscle contraction (GO:0003009)3.29897918
113regulation of apoptotic process involved in morphogenesis (GO:1902337)3.29543540
114alpha-amino acid catabolic process (GO:1901606)3.28577467
115sodium-independent organic anion transport (GO:0043252)3.27641671
116sodium ion transport (GO:0006814)3.27371851
117transepithelial transport (GO:0070633)3.26158232
118water transport (GO:0006833)3.24685577
119nephron epithelium morphogenesis (GO:0072088)3.23105392
120nephron tubule morphogenesis (GO:0072078)3.23105392
121actin filament-based movement (GO:0030048)3.21833630
122positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.21438126
123myofibril assembly (GO:0030239)3.21341803
124response to growth hormone (GO:0060416)3.21310055
125response to parathyroid hormone (GO:0071107)3.18976073
126sarcomere organization (GO:0045214)3.18883753
127cobalamin metabolic process (GO:0009235)3.18745791
128surfactant homeostasis (GO:0043129)3.17118120
129indole-containing compound metabolic process (GO:0042430)3.16340370
130organic acid catabolic process (GO:0016054)3.16156670
131carboxylic acid catabolic process (GO:0046395)3.16156670
132regulation of potassium ion transmembrane transport (GO:1901379)3.15860465
133cellular response to ammonium ion (GO:0071242)3.14849941
134response to vitamin A (GO:0033189)3.14618046
135regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.12295642
136fucose metabolic process (GO:0006004)3.09932682
137monocarboxylic acid catabolic process (GO:0072329)3.08582016
138calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.07994027
139L-methionine salvage (GO:0071267)3.07925856
140L-methionine biosynthetic process (GO:0071265)3.07925856
141amino acid salvage (GO:0043102)3.07925856
142dicarboxylic acid metabolic process (GO:0043648)3.06825740
143protein depolymerization (GO:0051261)3.06820862
144regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.00906622
145renal system process (GO:0003014)2.98662213
146relaxation of muscle (GO:0090075)2.98234771
147protein neddylation (GO:0045116)2.95502432
148skeletal muscle tissue regeneration (GO:0043403)2.92039288
149pattern specification involved in kidney development (GO:0061004)2.88932136
150regulation of anion transport (GO:0044070)2.86031950
151striated muscle contraction (GO:0006941)2.86007799
152negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.84756975
153positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.84274675
154fluid transport (GO:0042044)2.83856240
155regulation of integrin-mediated signaling pathway (GO:2001044)2.79533638
156regulation of lipoprotein metabolic process (GO:0050746)2.77714100
157regulation of fever generation (GO:0031620)2.75580401
158regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.74437185
159cellular carbohydrate catabolic process (GO:0044275)2.73736997
160response to salt stress (GO:0009651)2.72982189
161regulation of stem cell maintenance (GO:2000036)2.72284307
162relaxation of cardiac muscle (GO:0055119)2.72131519
163response to muscle activity (GO:0014850)2.71806682
164regulation of sulfur metabolic process (GO:0042762)2.69057786
165carnitine shuttle (GO:0006853)2.67711051
166urogenital system development (GO:0001655)2.65373419
167chloride transmembrane transport (GO:1902476)2.62006216
168response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.61064166
169glycogen catabolic process (GO:0005980)2.58725670
170regulation of platelet aggregation (GO:0090330)2.55319237
171S-adenosylmethionine metabolic process (GO:0046500)2.54772334
172glomerular visceral epithelial cell development (GO:0072015)2.54204111
173positive regulation of heat generation (GO:0031652)2.51362612
174neuronal action potential propagation (GO:0019227)2.50003852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.06997842
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.92711827
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.89872085
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.39363016
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.21159645
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.18339158
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.80713672
8EZH2_22144423_ChIP-Seq_EOC_Human2.78787023
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.55515407
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52314192
11GBX2_23144817_ChIP-Seq_PC3_Human2.51175289
12SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.50466556
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.34844871
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31194809
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.26488974
16SOX2_27498859_Chip-Seq_STOMACH_Mouse2.26208659
17CLOCK_20551151_ChIP-Seq_293T_Human2.18449991
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17523706
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08340288
20GATA4_25053715_ChIP-Seq_YYC3_Human2.04925999
21HTT_18923047_ChIP-ChIP_STHdh_Human2.04694283
22AR_21909140_ChIP-Seq_LNCAP_Human2.02086630
23VDR_22108803_ChIP-Seq_LS180_Human2.01251977
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99982528
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.94536619
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.92805958
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.91310627
28AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.89078920
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80266787
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.77800184
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.76726943
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.74965727
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73920369
34TAF15_26573619_Chip-Seq_HEK293_Human1.73073353
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72562383
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70923146
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67948181
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.67879259
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.64602534
40GATA6_25053715_ChIP-Seq_YYC3_Human1.64585225
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60571790
42SOX2_20726797_ChIP-Seq_SW620_Human1.60256026
43SMAD4_21799915_ChIP-Seq_A2780_Human1.57729965
44* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57144563
45FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.55486614
46TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55404095
47GATA1_19941827_ChIP-Seq_MEL86_Mouse1.54228909
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.51810625
49GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51782792
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49019670
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.48583498
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.48126088
53RXR_22108803_ChIP-Seq_LS180_Human1.46316859
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45322360
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43313262
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42284754
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.38348019
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37905719
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37590467
60AHR_22903824_ChIP-Seq_MCF-7_Human1.36893998
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34990971
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.34153937
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.33703206
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32754289
65GATA1_19941826_ChIP-Seq_K562_Human1.32339119
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.32008407
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31337145
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31019892
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.30961580
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.30961580
71SMAD3_21741376_ChIP-Seq_HESCs_Human1.30718775
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30242705
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.29804283
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29591816
75GATA1_22025678_ChIP-Seq_K562_Human1.28827453
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26386539
77* E2F1_18555785_Chip-Seq_ESCs_Mouse1.25768867
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.24901664
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.23329888
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22932872
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.22653516
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.22619235
83MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.21748051
84CDX2_22108803_ChIP-Seq_LS180_Human1.19721322
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16290650
86* P53_22387025_ChIP-Seq_ESCs_Mouse1.15986944
87SALL4_22934838_ChIP-ChIP_CD34+_Human1.15017186
88* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14916283
89TBL1_22424771_ChIP-Seq_293T_Human1.14873874
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13512330
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12275812
92PHF8_20622853_ChIP-Seq_HELA_Human1.12178524
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.12174280
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11791383
95LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09591425
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08639085
97ELK4_26923725_Chip-Seq_MESODERM_Mouse1.08612079
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08609866
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08430015
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08269663
101CBP_21632823_ChIP-Seq_H3396_Human1.07400831
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07278185
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06129999
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06113425
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05770211
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05477320
107RACK7_27058665_Chip-Seq_MCF-7_Human1.05347165
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04908699
109GF1_26923725_Chip-Seq_HPCs_Mouse1.03653428
110CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03394702
111NFYA_21822215_ChIP-Seq_K562_Human1.03119918
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02833113
113GF1B_26923725_Chip-Seq_HPCs_Mouse1.02373219
114ZFX_18555785_Chip-Seq_ESCs_Mouse1.02366603
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02365393
116RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01869974
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01734314
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01734314
119HNFA_21074721_ChIP-Seq_CACO-2_Human1.01625839
120GATA3_24758297_ChIP-Seq_MCF-7_Human1.00535663
121PU1_27457419_Chip-Seq_LIVER_Mouse0.99943394
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.99741041
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99406073
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98587920
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.98535409
126TP63_23658742_ChIP-Seq_EP156T_Human0.97985915
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.97845033
128FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97542223
129NFYB_21822215_ChIP-Seq_K562_Human0.97339336
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.96475170
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.95806464
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93777397
133SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93544872
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93080984
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93024530
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92585257
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92146067
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90090299
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89536693
140LXR_22292898_ChIP-Seq_THP-1_Human0.89012339
141EGR1_19032775_ChIP-ChIP_M12_Human0.88974311
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87967863
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.86882164
144CREB1_26743006_Chip-Seq_LNCaP_Human0.86717563
145CJUN_26792858_Chip-Seq_BT549_Human0.86703433
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85384895
147CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83887183
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83160809
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82619450
150Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81579125
151* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81450255
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80908566
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80738750
154GATA2_19941826_ChIP-Seq_K562_Human0.80075525
155ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78896253
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.77406000
157GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74342805
158SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72632515
159BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72024838
160NANOG_19829295_ChIP-Seq_ESCs_Human0.71145412
161SOX2_19829295_ChIP-Seq_ESCs_Human0.71145412
162MTF2_20144788_ChIP-Seq_MESCs_Mouse0.71072100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation8.01108004
2MP0005360_urolithiasis6.00706499
3MP0005332_abnormal_amino_acid4.70102141
4MP0001765_abnormal_ion_homeostasis4.38108585
5MP0003195_calcinosis4.37960268
6MP0009643_abnormal_urine_homeostasis4.09893848
7MP0004019_abnormal_vitamin_homeostasis4.02624753
8MP0001756_abnormal_urination3.99146383
9MP0002139_abnormal_hepatobiliary_system3.54630529
10MP0005636_abnormal_mineral_homeostasis3.36177508
11MP0002136_abnormal_kidney_physiology3.18369596
12MP0002138_abnormal_hepatobiliary_system3.17034376
13MP0005464_abnormal_platelet_physiology2.37249850
14MP0003300_gastrointestinal_ulcer2.35161208
15MP0004036_abnormal_muscle_relaxation2.33929079
16MP0008004_abnormal_stomach_pH2.29764078
17MP0004084_abnormal_cardiac_muscle2.27350890
18MP0005377_hearing/vestibular/ear_phenot2.27344472
19MP0003878_abnormal_ear_physiology2.27344472
20MP0001958_emphysema2.22765013
21MP0003252_abnormal_bile_duct2.16719443
22MP0005365_abnormal_bile_salt2.11278114
23MP0008875_abnormal_xenobiotic_pharmacok2.09363601
24MP0004145_abnormal_muscle_electrophysio2.05498537
25MP0000749_muscle_degeneration2.01566901
26MP0008961_abnormal_basal_metabolism1.97749318
27MP0000538_abnormal_urinary_bladder1.93294666
28MP0005058_abnormal_lysosome_morphology1.88336411
29MP0010234_abnormal_vibrissa_follicle1.79858976
30MP0000751_myopathy1.79612180
31MP0000230_abnormal_systemic_arterial1.62975281
32MP0005310_abnormal_salivary_gland1.61722479
33MP0004885_abnormal_endolymph1.61450417
34MP0002876_abnormal_thyroid_physiology1.60558491
35MP0004130_abnormal_muscle_cell1.60196636
36MP0003186_abnormal_redox_activity1.57740315
37MP0004215_abnormal_myocardial_fiber1.57643930
38MP0005451_abnormal_body_composition1.53548043
39MP0010386_abnormal_urinary_bladder1.50995537
40MP0004510_myositis1.49041665
41MP0001666_abnormal_nutrient_absorption1.42823826
42MP0005620_abnormal_muscle_contractility1.42440684
43MP0005085_abnormal_gallbladder_physiolo1.40325686
44MP0002135_abnormal_kidney_morphology1.36174229
45MP0002106_abnormal_muscle_physiology1.31778235
46MP0005220_abnormal_exocrine_pancreas1.31548028
47MP0004264_abnormal_extraembryonic_tissu1.31447509
48MP0005319_abnormal_enzyme/_coenzyme1.29494428
49MP0005584_abnormal_enzyme/coenzyme_acti1.29464684
50MP0004087_abnormal_muscle_fiber1.25346300
51MP0002972_abnormal_cardiac_muscle1.24252827
52MP0002168_other_aberrant_phenotype1.23863495
53MP0005369_muscle_phenotype1.11081286
54MP0002928_abnormal_bile_duct1.10847187
55MP0005647_abnormal_sex_gland1.10699148
56MP0003879_abnormal_hair_cell1.10461492
57MP0009764_decreased_sensitivity_to1.08639771
58MP0008775_abnormal_heart_ventricle1.07034917
59MP0002896_abnormal_bone_mineralization1.05538992
60MP0005084_abnormal_gallbladder_morpholo1.04594393
61MP0001764_abnormal_homeostasis1.01780063
62MP0004147_increased_porphyrin_level1.00172575
63MP0002166_altered_tumor_susceptibility0.99705279
64MP0003283_abnormal_digestive_organ0.99396810
65MP0006036_abnormal_mitochondrial_physio0.97780928
66MP0005666_abnormal_adipose_tissue0.97749882
67MP0005535_abnormal_body_temperature0.97078290
68MP0008872_abnormal_physiological_respon0.96030760
69MP0002269_muscular_atrophy0.92107090
70MP0003959_abnormal_lean_body0.91627882
71MP0005330_cardiomyopathy0.90799565
72MP0000759_abnormal_skeletal_muscle0.90734520
73MP0003638_abnormal_response/metabolism_0.90694462
74MP0009672_abnormal_birth_weight0.88024141
75MP0005670_abnormal_white_adipose0.87380498
76MP0002332_abnormal_exercise_endurance0.87346651
77MP0005083_abnormal_biliary_tract0.84564606
78MP0000465_gastrointestinal_hemorrhage0.84330172
79MP0005385_cardiovascular_system_phenoty0.79583168
80MP0001544_abnormal_cardiovascular_syste0.79583168
81MP0006138_congestive_heart_failure0.77910779
82MP0001661_extended_life_span0.77425973
83MP0000534_abnormal_ureter_morphology0.76953701
84MP0002118_abnormal_lipid_homeostasis0.74932388
85MP0009642_abnormal_blood_homeostasis0.72444938
86MP0000747_muscle_weakness0.71917857
87MP0002127_abnormal_cardiovascular_syste0.67827917
88MP0002971_abnormal_brown_adipose0.67777878
89MP0009780_abnormal_chondrocyte_physiolo0.66497186
90MP0003646_muscle_fatigue0.66096997
91MP0010630_abnormal_cardiac_muscle0.65913291
92MP0003566_abnormal_cell_adhesion0.65767387
93MP0003137_abnormal_impulse_conducting0.63497922
94MP0005395_other_phenotype0.63395902
95MP0001879_abnormal_lymphatic_vessel0.61335343
96MP0001664_abnormal_digestion0.60631880
97MP0002089_abnormal_postnatal_growth/wei0.59175343
98MP0002108_abnormal_muscle_morphology0.58695526
99MP0004272_abnormal_basement_membrane0.58468456
100MP0001873_stomach_inflammation0.57332230
101MP0002006_tumorigenesis0.56903425
102MP0005165_increased_susceptibility_to0.55754436
103MP0003828_pulmonary_edema0.55646215
104MP0000750_abnormal_muscle_regeneration0.54743609
105MP0002295_abnormal_pulmonary_circulatio0.54563545
106MP0004085_abnormal_heartbeat0.54457408
107MP0000537_abnormal_urethra_morphology0.53718850
108MP0003136_yellow_coat_color0.53612704
109MP0002078_abnormal_glucose_homeostasis0.53048209
110MP0000371_diluted_coat_color0.51793981
111MP0001944_abnormal_pancreas_morphology0.51203583
112MP0003315_abnormal_perineum_morphology0.50838245
113MP0003795_abnormal_bone_structure0.50297668
114MP0008469_abnormal_protein_level0.50288637
115MP0003191_abnormal_cellular_cholesterol0.50211651
116MP0000609_abnormal_liver_physiology0.49740099
117MP0001270_distended_abdomen0.49431604
118MP0003806_abnormal_nucleotide_metabolis0.49423379
119MP0000013_abnormal_adipose_tissue0.48812639
120MP0002796_impaired_skin_barrier0.48452374
121MP0004233_abnormal_muscle_weight0.48048254
122MP0002098_abnormal_vibrissa_morphology0.47989021
123MP0009765_abnormal_xenobiotic_induced0.47632582
124MP0004484_altered_response_of0.47457094
125MP0010368_abnormal_lymphatic_system0.46984910
126MP0001663_abnormal_digestive_system0.46556250
127MP0003172_abnormal_lysosome_physiology0.46423790
128MP0002069_abnormal_eating/drinking_beha0.46372933
129MP0002115_abnormal_skeleton_extremities0.46021899
130MP0003183_abnormal_peptide_metabolism0.45876202
131MP0001191_abnormal_skin_condition0.45664055
132MP0003953_abnormal_hormone_level0.45272391
133MP0005166_decreased_susceptibility_to0.45227001
134MP0009703_decreased_birth_body0.44808149
135MP0002128_abnormal_blood_circulation0.44721267
136MP0005375_adipose_tissue_phenotype0.44217129
137MP0010329_abnormal_lipoprotein_level0.43810869
138MP0005408_hypopigmentation0.43542700
139MP0003724_increased_susceptibility_to0.42055512
140MP0003011_delayed_dark_adaptation0.40374588
141MP0003045_fibrosis0.40114399
142MP0002998_abnormal_bone_remodeling0.39418234
143MP0000163_abnormal_cartilage_morphology0.38513224
144MP0003656_abnormal_erythrocyte_physiolo0.37770122
145MP0001784_abnormal_fluid_regulation0.37438456
146MP0000598_abnormal_liver_morphology0.36598320
147MP0006054_spinal_hemorrhage0.36547725
148MP0005381_digestive/alimentary_phenotyp0.35847153
149MP0001845_abnormal_inflammatory_respons0.35407946

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)9.11905920
2Hypokalemic alkalosis (HP:0001949)8.48986586
3Metabolic alkalosis (HP:0200114)8.17027387
4Hyperactive renin-angiotensin system (HP:0000841)7.66375751
5Abnormality of chloride homeostasis (HP:0011422)7.22864109
6Polyuria (HP:0000103)7.22162861
7Abnormal urine output (HP:0012590)6.95077185
8* Hypomagnesemia (HP:0002917)6.87061395
9Abnormality of renal excretion (HP:0011036)6.49051955
10Gout (HP:0001997)6.26097491
11Polydipsia (HP:0001959)6.09218029
12Abnormal drinking behavior (HP:0030082)6.09218029
13Tetany (HP:0001281)5.88280457
14* Abnormality of magnesium homeostasis (HP:0004921)5.70981336
15Abnormality of renin-angiotensin system (HP:0000847)5.41251713
16Renal salt wasting (HP:0000127)5.38749044
17Hyperaldosteronism (HP:0000859)5.38619930
18Alkalosis (HP:0001948)5.13867660
19Proximal tubulopathy (HP:0000114)4.75089477
20Hyperglycinuria (HP:0003108)4.70105465
21Increased purine levels (HP:0004368)4.51094583
22Hyperuricemia (HP:0002149)4.51094583
23Hypokalemia (HP:0002900)4.48379529
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09218796
25Abnormality of purine metabolism (HP:0004352)3.89278672
26Abnormality of serine family amino acid metabolism (HP:0010894)3.76615012
27Abnormality of glycine metabolism (HP:0010895)3.76615012
28Abnormality of potassium homeostasis (HP:0011042)3.73588405
29Hypercalciuria (HP:0002150)3.67955516
30Nemaline bodies (HP:0003798)3.60119177
31Generalized aminoaciduria (HP:0002909)3.50833214
32Muscle fiber inclusion bodies (HP:0100299)3.50746118
33Ketoacidosis (HP:0001993)3.49239814
34Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.43025374
35Renal tubular acidosis (HP:0001947)3.12369357
36Hydroxyprolinuria (HP:0003080)3.01272775
37Abnormality of proline metabolism (HP:0010907)3.01272775
38Abnormality of fatty-acid metabolism (HP:0004359)2.99343861
39Ketosis (HP:0001946)2.93746232
40Abnormality of urine glucose concentration (HP:0011016)2.89379712
41Glycosuria (HP:0003076)2.89379712
42Abnormality of sodium homeostasis (HP:0010931)2.78666912
43Vacuolated lymphocytes (HP:0001922)2.74905414
44Nephrocalcinosis (HP:0000121)2.74904071
45Potter facies (HP:0002009)2.72841252
46Facial shape deformation (HP:0011334)2.72841252
47Hyponatremia (HP:0002902)2.71934910
48Abnormality of nucleobase metabolism (HP:0010932)2.70655719
49Large eyes (HP:0001090)2.66465568
50Hyperglycinemia (HP:0002154)2.59218411
51Impaired platelet aggregation (HP:0003540)2.58753580
52Abnormal platelet function (HP:0011869)2.58753580
53Dehydration (HP:0001944)2.57913082
54Exercise-induced myalgia (HP:0003738)2.55608981
55Widely patent fontanelles and sutures (HP:0004492)2.51810002
56Adrenal overactivity (HP:0002717)2.43506741
57Vascular calcification (HP:0004934)2.39672278
58Hyperphosphaturia (HP:0003109)2.39072437
59Exercise-induced muscle cramps (HP:0003710)2.38016174
60Abnormal urine phosphate concentration (HP:0012599)2.34527823
61Delayed epiphyseal ossification (HP:0002663)2.32500941
62Type 1 muscle fiber predominance (HP:0003803)2.32487893
63Chondrocalcinosis (HP:0000934)2.30550703
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26011196
65Hypophosphatemia (HP:0002148)2.25967477
66Nephrolithiasis (HP:0000787)2.23002431
67Tubular atrophy (HP:0000092)2.19556622
68Abnormality of Sharpey fibers (HP:0100685)2.18126624
69Glomerulosclerosis (HP:0000096)2.14156297
70Cardiovascular calcification (HP:0011915)2.12196868
71Abnormality of renal resorption (HP:0011038)2.11270795
72Increased mean platelet volume (HP:0011877)2.11242506
73Tubulointerstitial fibrosis (HP:0005576)2.05862622
74Rickets (HP:0002748)2.05588296
75Generalized muscle weakness (HP:0003324)2.04666220
76Metaphyseal cupping (HP:0003021)2.04272945
77Hypotension (HP:0002615)2.02010876
78Menorrhagia (HP:0000132)2.00679129
79Delayed CNS myelination (HP:0002188)2.00062101
80Prolonged bleeding time (HP:0003010)1.98443852
81Vomiting (HP:0002013)1.97895685
82Abnormality of sulfur amino acid metabolism (HP:0004339)1.95856563
83Metabolic acidosis (HP:0001942)1.95302130
84Hyperammonemia (HP:0001987)1.95055919
85Enlarged kidneys (HP:0000105)1.94009487
86Abnormal tarsal ossification (HP:0008369)1.92590197
87Abnormality of cochlea (HP:0000375)1.90722795
88Abnormal platelet volume (HP:0011876)1.90355303
89Renal tubular dysfunction (HP:0000124)1.81417327
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80824454
91Dicarboxylic aciduria (HP:0003215)1.80824454
92Decreased circulating renin level (HP:0003351)1.76539459
93Abnormal enzyme/coenzyme activity (HP:0012379)1.75159389
94Muscle hypertrophy of the lower extremities (HP:0008968)1.73907009
95Focal segmental glomerulosclerosis (HP:0000097)1.73003829
96Abnormality of alkaline phosphatase activity (HP:0004379)1.72646346
97Hyperkalemia (HP:0002153)1.72011898
98Malnutrition (HP:0004395)1.70068622
99Muscle fiber splitting (HP:0003555)1.69860634
100Lymphangioma (HP:0100764)1.69650179
101Petechiae (HP:0000967)1.69096744
102Abnormality of the costochondral junction (HP:0000919)1.68527104
103Bilateral sensorineural hearing impairment (HP:0008619)1.66765073
104Methylmalonic aciduria (HP:0012120)1.62127325
105Thin bony cortex (HP:0002753)1.61901663
106Tachypnea (HP:0002789)1.60317936
107Paralysis (HP:0003470)1.59433831
108Calf muscle hypertrophy (HP:0008981)1.58502714
109Myoglobinuria (HP:0002913)1.56915982
110Dysostosis multiplex (HP:0000943)1.56707683
111Lethargy (HP:0001254)1.56475237
112Confusion (HP:0001289)1.55465806
113Bicornuate uterus (HP:0000813)1.53947031
114Mucopolysacchariduria (HP:0008155)1.48473967
115Urinary glycosaminoglycan excretion (HP:0003541)1.48473967
116Rhabdomyolysis (HP:0003201)1.47685294
117Myopathic facies (HP:0002058)1.46415431
118Abnormality of the renal cortex (HP:0011035)1.46303626
119Distal arthrogryposis (HP:0005684)1.45009118
120Elevated alkaline phosphatase (HP:0003155)1.44316007
121EMG: myopathic abnormalities (HP:0003458)1.44124492
122Wide cranial sutures (HP:0010537)1.43764919
123Hyporeflexia of lower limbs (HP:0002600)1.41930992
124Tubulointerstitial abnormality (HP:0001969)1.39706355
125Purpura (HP:0000979)1.38631257
126Abnormality of the calf musculature (HP:0001430)1.34371708
127Rimmed vacuoles (HP:0003805)1.32509382
128Difficulty running (HP:0009046)1.32203767
129Neonatal onset (HP:0003623)1.30428722
130Premature birth (HP:0001622)1.28294521
131Nephrogenic diabetes insipidus (HP:0009806)1.26449259
132Neck muscle weakness (HP:0000467)1.22474425
133Abnormality of skeletal muscle fiber size (HP:0012084)1.20485813
134Paresthesia (HP:0003401)1.19633731
135Osteopenia (HP:0000938)1.19006271
136Epistaxis (HP:0000421)1.15778603
137Centrally nucleated skeletal muscle fibers (HP:0003687)1.13887686
138Abnormality of the renal medulla (HP:0100957)1.12919276
139Polyhydramnios (HP:0001561)1.11065284
140Metaphyseal dysplasia (HP:0100255)1.10937053
141Hip contracture (HP:0003273)1.10830898
142Thyroid-stimulating hormone excess (HP:0002925)1.10594610
143Distal lower limb muscle weakness (HP:0009053)1.06933801
144Frequent falls (HP:0002359)1.06558672
145Subaortic stenosis (HP:0001682)1.06125690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.47777795
2OXSR17.83780214
3WNK37.81234107
4STK395.46185947
5BCKDK2.89348018
6MST42.00987765
7STK38L1.85421947
8ERN11.65253097
9AKT31.64222056
10WNK11.63218019
11FRK1.59678875
12PDK21.55388462
13LATS11.53372799
14SGK2231.52494468
15SGK4941.52494468
16PDK31.40585136
17PDK41.40585136
18SGK21.14394467
19SGK31.02400656
20NEK10.98968632
21TAOK30.92058054
22INSRR0.89299552
23STK380.86887375
24TIE10.86192518
25LRRK20.82969774
26MST1R0.77729494
27MYLK0.76155137
28BMX0.74169954
29TGFBR20.70577891
30EIF2AK10.64673075
31PINK10.60651344
32SIK10.57354638
33PTK60.57198264
34PRKAA10.54719555
35MAP3K70.54394732
36SCYL20.54028000
37MAP3K20.49379937
38MAP3K30.48677614
39PTK2B0.48104362
40DMPK0.48059047
41EPHB10.46755841
42GSK3A0.44991520
43SGK10.43822061
44STK240.43419062
45EEF2K0.41983326
46PDPK10.41383189
47TEC0.40559334
48PIK3CG0.40264306
49MAPKAPK30.37810462
50RIPK40.37504874
51FER0.36184764
52PRKCI0.35979927
53TNIK0.35856943
54STK100.35275863
55TRIB30.35089081
56PRKD20.35066191
57BRSK20.34145846
58FGFR40.32080804
59PRKAA20.31357347
60MAP2K40.31208574
61NLK0.30681446
62PTK20.28270126
63PDGFRA0.26703305
64PDK10.26462775
65ZAP700.25722565
66PNCK0.25674944
67PAK40.24722276
68BTK0.24669312
69NEK90.24339721
70TRIM280.23734984
71TTN0.23627278
72ERBB30.23617989
73NUAK10.23050519
74LMTK20.20959613
75MAP2K30.20489035
76JAK20.20212175
77MET0.19978538
78MUSK0.19918155
79ABL20.18632309
80PLK20.18281353
81ACVR1B0.18049535
82NEK60.17350536
83MAP3K140.17276856
84PRKG10.17031810
85GRK50.16622733
86TRPM70.16097763
87PRKACA0.16025092
88STK30.16003143
89FGR0.15563057
90MAPK110.15184324
91NME10.14344898
92RET0.13572241
93NTRK10.13235980
94PAK30.13053691
95PRKCZ0.12625298
96IRAK30.12611275
97CSF1R0.12590938
98TNK20.11756474
99BMPR1B0.11434869
100TGFBR10.11225715
101CAMK2G0.11175115
102AKT20.10910939
103ILK0.10745008
104ROCK10.10637869
105DYRK1B0.10598051
106MAP2K10.10139026
107EPHA30.09588075
108JAK10.09526163
109MAP2K20.09260603
110ARAF0.09171081
111MAP3K50.08884389
112MAPK120.08662913
113CCNB10.07625885
114HCK0.07443711
115IRAK10.07172214
116PRKCH0.07109764
117MARK30.06714839
118MTOR0.06306152
119EPHA20.05951245
120PKN10.05878720
121STK110.05848232
122YES10.05840605
123RIPK10.05561303
124PKN20.05338259
125SYK0.05250692
126PRKCA0.05072090
127PRKCQ0.04950867
128MAP3K120.04914262
129PAK10.04362109
130JAK30.04295172
131PRKCD0.04118937
132OBSCN0.04020441
133PIK3CA0.04009812
134MOS0.03566582
135PRKD10.03513248
136PRKCB0.03427401
137EPHB20.03167991
138CSNK1A10.03130505
139PRKACG0.03102376
140KSR20.03084169
141CAMK2D0.03036523
142KSR10.02522414
143EIF2AK30.02421771
144ADRBK20.01407803
145PHKG20.01098918
146PHKG10.01098918
147TAOK10.00943755
148RAF10.00841425
149ADRBK10.00809913
150MAP3K40.00623248

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.52511592
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.50300249
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.47330157
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.15365526
5Butanoate metabolism_Homo sapiens_hsa006503.08821345
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.00070149
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.92011000
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91093838
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63049321
10Collecting duct acid secretion_Homo sapiens_hsa049662.60395157
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.44961538
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37871428
13Fatty acid degradation_Homo sapiens_hsa000712.37751611
14Sulfur metabolism_Homo sapiens_hsa009202.36801965
15Platelet activation_Homo sapiens_hsa046112.28466610
16Pyruvate metabolism_Homo sapiens_hsa006202.23692394
17Peroxisome_Homo sapiens_hsa041462.20855022
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.17111129
19Vitamin digestion and absorption_Homo sapiens_hsa049772.08838961
20Tryptophan metabolism_Homo sapiens_hsa003802.04095663
21Protein digestion and absorption_Homo sapiens_hsa049741.91396778
22beta-Alanine metabolism_Homo sapiens_hsa004101.82816344
23Dilated cardiomyopathy_Homo sapiens_hsa054141.77215678
24Other glycan degradation_Homo sapiens_hsa005111.74826160
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.70620198
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70277944
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67640555
28Fatty acid metabolism_Homo sapiens_hsa012121.64682367
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61581375
30Bile secretion_Homo sapiens_hsa049761.59344220
31Carbon metabolism_Homo sapiens_hsa012001.56166600
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55936463
33Renin-angiotensin system_Homo sapiens_hsa046141.52239199
34Circadian rhythm_Homo sapiens_hsa047101.51034275
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48956178
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48948671
37Arginine and proline metabolism_Homo sapiens_hsa003301.44436279
38Lysine degradation_Homo sapiens_hsa003101.44317011
39Mineral absorption_Homo sapiens_hsa049781.33046879
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24878811
41Glutathione metabolism_Homo sapiens_hsa004801.24664559
42Arginine biosynthesis_Homo sapiens_hsa002201.19510295
43PPAR signaling pathway_Homo sapiens_hsa033201.14819910
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14747719
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10026878
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.08869603
47Fructose and mannose metabolism_Homo sapiens_hsa000511.06757025
48Starch and sucrose metabolism_Homo sapiens_hsa005001.02809646
49Selenocompound metabolism_Homo sapiens_hsa004501.02480565
50Insulin signaling pathway_Homo sapiens_hsa049101.02071054
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00409656
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96195672
53Cardiac muscle contraction_Homo sapiens_hsa042600.96063791
54Glycerolipid metabolism_Homo sapiens_hsa005610.95558150
55Biosynthesis of amino acids_Homo sapiens_hsa012300.93049877
56Folate biosynthesis_Homo sapiens_hsa007900.91153897
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87923906
58Vibrio cholerae infection_Homo sapiens_hsa051100.86955449
59Lysosome_Homo sapiens_hsa041420.85527182
60Thyroid hormone synthesis_Homo sapiens_hsa049180.83160931
61Adherens junction_Homo sapiens_hsa045200.83145951
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82495497
63Thyroid cancer_Homo sapiens_hsa052160.79534595
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76512383
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74641900
66Calcium signaling pathway_Homo sapiens_hsa040200.71023498
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.70201333
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.68615282
69Gastric acid secretion_Homo sapiens_hsa049710.67073842
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66687496
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66172878
72* Focal adhesion_Homo sapiens_hsa045100.65560004
73Histidine metabolism_Homo sapiens_hsa003400.65020043
74* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63025564
75ABC transporters_Homo sapiens_hsa020100.60937318
76Oxidative phosphorylation_Homo sapiens_hsa001900.60127586
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.59153850
78Nitrogen metabolism_Homo sapiens_hsa009100.58819674
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57714377
80Retinol metabolism_Homo sapiens_hsa008300.55289472
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.55256029
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53647941
83Metabolic pathways_Homo sapiens_hsa011000.52393643
84Phenylalanine metabolism_Homo sapiens_hsa003600.49176696
85Oxytocin signaling pathway_Homo sapiens_hsa049210.48427579
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47376875
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47289829
88Fatty acid elongation_Homo sapiens_hsa000620.45960737
89Pancreatic secretion_Homo sapiens_hsa049720.45102184
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43705803
91* Gap junction_Homo sapiens_hsa045400.43218920
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42966451
93* FoxO signaling pathway_Homo sapiens_hsa040680.42853189
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42778665
95N-Glycan biosynthesis_Homo sapiens_hsa005100.39814307
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37763687
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35961091
98Insulin resistance_Homo sapiens_hsa049310.35534546
99Inositol phosphate metabolism_Homo sapiens_hsa005620.34385202
100Serotonergic synapse_Homo sapiens_hsa047260.30134942
101Pentose phosphate pathway_Homo sapiens_hsa000300.29643706
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29622633
103Renin secretion_Homo sapiens_hsa049240.29374417
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29181961
105Protein export_Homo sapiens_hsa030600.28671531
106Sphingolipid metabolism_Homo sapiens_hsa006000.28385566
107Sulfur relay system_Homo sapiens_hsa041220.27755696
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27521119
109Synaptic vesicle cycle_Homo sapiens_hsa047210.27152680
110Arachidonic acid metabolism_Homo sapiens_hsa005900.26375892
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.25987237
112ECM-receptor interaction_Homo sapiens_hsa045120.25434427
113Chemical carcinogenesis_Homo sapiens_hsa052040.23858757
114Tight junction_Homo sapiens_hsa045300.23289037
115AMPK signaling pathway_Homo sapiens_hsa041520.19778130
116Galactose metabolism_Homo sapiens_hsa000520.16576734
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.15534820
118Rheumatoid arthritis_Homo sapiens_hsa053230.14656667
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14286032
120Regulation of autophagy_Homo sapiens_hsa041400.14024813
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.11578072
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11431104
123Small cell lung cancer_Homo sapiens_hsa052220.08548912
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06526993
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06006072
126Amoebiasis_Homo sapiens_hsa051460.05930530
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.05460347
128Glucagon signaling pathway_Homo sapiens_hsa049220.05042587
129* Choline metabolism in cancer_Homo sapiens_hsa052310.03198361
130Alzheimers disease_Homo sapiens_hsa050100.03152416
131Parkinsons disease_Homo sapiens_hsa050120.03043934

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