EFNB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.98374555
2central nervous system myelination (GO:0022010)7.98374555
3striatum development (GO:0021756)5.44479325
4adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.33065188
5peristalsis (GO:0030432)5.16619312
6cell proliferation in forebrain (GO:0021846)5.09191766
7phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.95683676
8regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.93944652
9regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.93944652
10lens fiber cell development (GO:0070307)4.82979691
11positive regulation of synapse assembly (GO:0051965)4.68073681
12myelination (GO:0042552)4.65536793
13axon ensheathment (GO:0008366)4.64942471
14ensheathment of neurons (GO:0007272)4.64942471
15dopamine transport (GO:0015872)4.48628132
16pyrimidine nucleobase catabolic process (GO:0006208)4.48462154
17neuron projection extension involved in neuron projection guidance (GO:1902284)4.46550125
18axon extension involved in axon guidance (GO:0048846)4.46550125
19behavioral response to cocaine (GO:0048148)4.39999244
20establishment of mitochondrion localization (GO:0051654)4.35535127
21synaptic vesicle maturation (GO:0016188)4.30822956
22neuronal stem cell maintenance (GO:0097150)4.19174279
23neuron cell-cell adhesion (GO:0007158)4.16865056
24prepulse inhibition (GO:0060134)4.12208423
25fatty acid elongation (GO:0030497)4.10757891
26dendritic spine morphogenesis (GO:0060997)4.07397277
27neuron fate determination (GO:0048664)4.03696437
28long-chain fatty acid biosynthetic process (GO:0042759)3.99199528
29negative regulation of axon guidance (GO:1902668)3.93085613
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.91194004
31negative regulation of protein localization to cell surface (GO:2000009)3.90157523
32maternal behavior (GO:0042711)3.87696356
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.83675667
34retinal ganglion cell axon guidance (GO:0031290)3.82665975
35regulation of neurotransmitter uptake (GO:0051580)3.79373285
36neuronal ion channel clustering (GO:0045161)3.76022325
37negative regulation of oligodendrocyte differentiation (GO:0048715)3.72535951
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.72275986
39presynaptic membrane organization (GO:0097090)3.70042336
40synaptic transmission, dopaminergic (GO:0001963)3.68916407
41layer formation in cerebral cortex (GO:0021819)3.60099910
42nucleobase catabolic process (GO:0046113)3.57000105
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56938347
44regulation of synapse assembly (GO:0051963)3.56746210
45locomotory exploration behavior (GO:0035641)3.55130544
46transmission of nerve impulse (GO:0019226)3.52941835
47negative regulation of neurotransmitter transport (GO:0051589)3.52302646
48cochlea development (GO:0090102)3.50946585
49peptidyl-tyrosine autophosphorylation (GO:0038083)3.50264571
50neuronal action potential propagation (GO:0019227)3.49547542
51axonal fasciculation (GO:0007413)3.49341856
52* neuron recognition (GO:0008038)3.47069648
53postsynaptic membrane organization (GO:0001941)3.46545504
54regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.45554231
55catecholamine transport (GO:0051937)3.45389753
56neuronal action potential (GO:0019228)3.45136632
57myelin maintenance (GO:0043217)3.44856652
58protein localization to synapse (GO:0035418)3.44020574
59vocalization behavior (GO:0071625)3.41906789
60negative regulation of neurotransmitter secretion (GO:0046929)3.41424992
61presynaptic membrane assembly (GO:0097105)3.41287961
62ionotropic glutamate receptor signaling pathway (GO:0035235)3.40064002
63L-amino acid import (GO:0043092)3.38633836
64synaptic vesicle exocytosis (GO:0016079)3.38382360
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.37714557
66parental behavior (GO:0060746)3.34594585
67establishment of nucleus localization (GO:0040023)3.34567968
68phasic smooth muscle contraction (GO:0014821)3.33857750
69behavioral defense response (GO:0002209)3.28991593
70behavioral fear response (GO:0001662)3.28991593
71regulation of synaptic vesicle exocytosis (GO:2000300)3.28858840
72dendrite morphogenesis (GO:0048813)3.27571030
73negative regulation of axonogenesis (GO:0050771)3.27470435
74behavioral response to nicotine (GO:0035095)3.25997325
75glycine transport (GO:0015816)3.25922385
76regulation of neuronal synaptic plasticity (GO:0048168)3.25496886
77cerebral cortex radially oriented cell migration (GO:0021799)3.24208055
78regulation of synaptic transmission, dopaminergic (GO:0032225)3.22539845
79oligodendrocyte differentiation (GO:0048709)3.21312204
80dentate gyrus development (GO:0021542)3.18806026
81regulation of synapse structural plasticity (GO:0051823)3.17643839
82apical protein localization (GO:0045176)3.17357612
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15630658
84glutamate secretion (GO:0014047)3.14807341
85* adult walking behavior (GO:0007628)3.14534354
86positive regulation of potassium ion transport (GO:0043268)3.14303714
87regulation of axon guidance (GO:1902667)3.13811282
88gamma-aminobutyric acid transport (GO:0015812)3.10215079
89cell differentiation in hindbrain (GO:0021533)3.09349131
90somatic stem cell division (GO:0048103)3.09183763
91axonemal dynein complex assembly (GO:0070286)3.08149346
92establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.06651501
93mitochondrion transport along microtubule (GO:0047497)3.06651501
94synapse assembly (GO:0007416)3.05783447
95regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05460236
96regulation of dendritic spine morphogenesis (GO:0061001)3.04892631
97dopamine receptor signaling pathway (GO:0007212)3.04465578
98regulation of collateral sprouting (GO:0048670)3.04287013
99spinal cord development (GO:0021510)3.02572458
100lateral sprouting from an epithelium (GO:0060601)3.02358602
101regulation of glutamate receptor signaling pathway (GO:1900449)3.01831678
102stem cell development (GO:0048864)3.01679648
103sex differentiation (GO:0007548)3.01639165
104epithelial cell differentiation involved in kidney development (GO:0035850)3.00796391
105establishment of planar polarity (GO:0001736)2.98212265
106establishment of tissue polarity (GO:0007164)2.98212265
107epithelial cilium movement (GO:0003351)2.95412342
108axon extension (GO:0048675)2.94962285
109negative regulation of axon extension (GO:0030517)2.94902950
110synaptic transmission, glutamatergic (GO:0035249)2.94728093
111glutamate receptor signaling pathway (GO:0007215)2.94515568
112substantia nigra development (GO:0021762)2.93930382
113glomerulus development (GO:0032835)2.92862549
114nerve growth factor signaling pathway (GO:0038180)2.92829910
115fear response (GO:0042596)2.89511130
116membrane tubulation (GO:0097320)2.88744409
117nephron tubule morphogenesis (GO:0072078)2.87150447
118nephron epithelium morphogenesis (GO:0072088)2.87150447
119neuron-neuron synaptic transmission (GO:0007270)2.86043352
120neural precursor cell proliferation (GO:0061351)2.85722138
121cell migration in hindbrain (GO:0021535)2.85179338
122regulation of dopamine metabolic process (GO:0042053)2.85103007
123regulation of catecholamine metabolic process (GO:0042069)2.85103007
124substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.84248936
125substrate-independent telencephalic tangential migration (GO:0021826)2.84248936
126asymmetric protein localization (GO:0008105)2.83211695
127auditory behavior (GO:0031223)2.83051478
128response to amphetamine (GO:0001975)2.83000446
129negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82672049
130creatine metabolic process (GO:0006600)2.81938660
131exploration behavior (GO:0035640)2.81708651
132cilium movement (GO:0003341)2.81610897
133positive regulation of gastrulation (GO:2000543)2.81558393
134regulation of timing of cell differentiation (GO:0048505)2.81405273
135regulation of synapse organization (GO:0050807)2.81178818
136G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.80022558
137regulation of synaptic vesicle transport (GO:1902803)2.79852651
138response to methylmercury (GO:0051597)2.79367921
139multicellular organismal signaling (GO:0035637)2.79347743
140astrocyte development (GO:0014002)2.78258268
141cerebellar granule cell differentiation (GO:0021707)2.77367401
142negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.76609573
143positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.76323847
144regulation of dendritic spine development (GO:0060998)2.76181485
145positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75592022
146neuron remodeling (GO:0016322)2.75422281
147negative regulation of cAMP-mediated signaling (GO:0043951)2.75382680
148cellular response to catecholamine stimulus (GO:0071870)2.75057628
149cellular response to monoamine stimulus (GO:0071868)2.75057628
150long-term memory (GO:0007616)2.73982838
151mechanosensory behavior (GO:0007638)2.72763326
152dendritic spine organization (GO:0097061)2.72209941
153sequestering of actin monomers (GO:0042989)2.71549356
154eye photoreceptor cell differentiation (GO:0001754)2.70362728
155photoreceptor cell differentiation (GO:0046530)2.70362728
156organelle transport along microtubule (GO:0072384)2.69880080
157positive regulation of membrane potential (GO:0045838)2.68241881
158positive regulation of dendritic spine development (GO:0060999)2.68046932
159radial glial cell differentiation (GO:0060019)2.67174255
160cellular response to epinephrine stimulus (GO:0071872)2.66840661
161peripheral nervous system axon ensheathment (GO:0032292)2.66022020
162myelination in peripheral nervous system (GO:0022011)2.66022020
163glycerophospholipid catabolic process (GO:0046475)2.65096361
164regulation of voltage-gated calcium channel activity (GO:1901385)2.65060024
165neuromuscular process controlling balance (GO:0050885)2.64279382
166regulation of excitatory postsynaptic membrane potential (GO:0060079)2.63574028
167central nervous system projection neuron axonogenesis (GO:0021952)2.62855840
168mating behavior (GO:0007617)2.62018388
169negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56296495
170positive regulation of action potential (GO:0045760)2.54873335
171potassium ion import (GO:0010107)2.53948478
172positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53493042
173amino acid import (GO:0043090)2.53324869
174membrane hyperpolarization (GO:0060081)2.53236903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.69141970
2GBX2_23144817_ChIP-Seq_PC3_Human3.13824857
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97405509
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96896524
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92466605
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.71062967
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70437873
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70437873
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48324704
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48057897
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46804311
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43137807
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38950154
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.38805164
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38366778
16DROSHA_22980978_ChIP-Seq_HELA_Human2.35051703
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34228683
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.31585968
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.27815839
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.18863451
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09969215
22AR_21572438_ChIP-Seq_LNCaP_Human2.09330200
23* REST_21632747_ChIP-Seq_MESCs_Mouse2.08580102
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03815500
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88160654
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87176404
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86663006
28* REST_18959480_ChIP-ChIP_MESCs_Mouse1.81042019
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74744008
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.71216676
31TAF15_26573619_Chip-Seq_HEK293_Human1.69281707
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65640523
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61319492
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60804366
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55524043
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.52240518
37* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51727744
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50169848
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.48499050
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45856686
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45210720
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43615916
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42609033
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.38642337
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37791333
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37580156
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.34736405
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34103489
49* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33403605
50KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31156608
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29285986
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28485275
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27488902
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23340127
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23340127
56RING1B_27294783_Chip-Seq_NPCs_Mouse1.23231777
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23060103
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21204148
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20717515
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19069395
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.18824319
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18627691
63SMAD4_21799915_ChIP-Seq_A2780_Human1.18220640
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15261088
65* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14846828
66ER_23166858_ChIP-Seq_MCF-7_Human1.14599659
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13485682
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12738554
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.12588409
70ZNF274_21170338_ChIP-Seq_K562_Hela1.12273784
71P300_19829295_ChIP-Seq_ESCs_Human1.11986436
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11526844
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11109175
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08885289
75STAT3_23295773_ChIP-Seq_U87_Human1.07590335
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06227692
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05752053
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04877765
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.04850412
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04509489
81RNF2_27304074_Chip-Seq_NSC_Mouse1.04359069
82* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02712926
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02434942
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01841056
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01170372
86ARNT_22903824_ChIP-Seq_MCF-7_Human0.99840765
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99483906
88* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98538827
89ISL1_27105846_Chip-Seq_CPCs_Mouse0.97826215
90AHR_22903824_ChIP-Seq_MCF-7_Human0.97013270
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96055382
92CTCF_27219007_Chip-Seq_Bcells_Human0.95195480
93KDM2B_26808549_Chip-Seq_K562_Human0.94856071
94TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94424170
95VDR_22108803_ChIP-Seq_LS180_Human0.94352747
96AR_19668381_ChIP-Seq_PC3_Human0.93989246
97FUS_26573619_Chip-Seq_HEK293_Human0.93664368
98TCF4_23295773_ChIP-Seq_U87_Human0.93403554
99TP63_17297297_ChIP-ChIP_HaCaT_Human0.93370712
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93202990
101TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93097246
102GATA1_26923725_Chip-Seq_HPCs_Mouse0.92775203
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.92731870
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92605564
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92261975
106ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91804843
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.90198195
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89558688
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89108499
110JUN_21703547_ChIP-Seq_K562_Human0.88904478
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87987077
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87876394
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86990716
114STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85638488
115* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84716489
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84644280
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84311813
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83621300
119YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83455693
120AR_25329375_ChIP-Seq_VCAP_Human0.82620625
121RUNX2_22187159_ChIP-Seq_PCA_Human0.82388769
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82143956
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.80739318
124IGF1R_20145208_ChIP-Seq_DFB_Human0.80305607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.90945955
2MP0004270_analgesia3.75938403
3MP0000920_abnormal_myelination3.33426292
4* MP0003635_abnormal_synaptic_transmissio3.19463403
5MP0002653_abnormal_ependyma_morphology3.17479721
6* MP0003880_abnormal_central_pattern3.13340225
7MP0005423_abnormal_somatic_nervous2.90051839
8MP0002064_seizures2.81674838
9MP0009745_abnormal_behavioral_response2.73183971
10MP0001486_abnormal_startle_reflex2.69009180
11MP0002272_abnormal_nervous_system2.61837860
12MP0002063_abnormal_learning/memory/cond2.60260220
13MP0003329_amyloid_beta_deposits2.52714296
14* MP0000778_abnormal_nervous_system2.49565681
15MP0001529_abnormal_vocalization2.49543267
16MP0003283_abnormal_digestive_organ2.46550511
17MP0004885_abnormal_endolymph2.36849411
18MP0010030_abnormal_orbit_morphology2.36521576
19MP0009046_muscle_twitch2.31218560
20MP0002734_abnormal_mechanical_nocicepti2.23519522
21MP0002822_catalepsy2.20395266
22MP0002572_abnormal_emotion/affect_behav2.19235634
23MP0009379_abnormal_foot_pigmentation2.03563803
24MP0003690_abnormal_glial_cell1.98885033
25MP0002102_abnormal_ear_morphology1.88846115
26MP0001905_abnormal_dopamine_level1.84573532
27MP0003634_abnormal_glial_cell1.84090245
28MP0001440_abnormal_grooming_behavior1.82893999
29MP0004742_abnormal_vestibular_system1.82528457
30MP0002249_abnormal_larynx_morphology1.81190960
31MP0004142_abnormal_muscle_tone1.80403017
32MP0001970_abnormal_pain_threshold1.72212247
33MP0001968_abnormal_touch/_nociception1.72072867
34* MP0000955_abnormal_spinal_cord1.71865729
35MP0008569_lethality_at_weaning1.69979913
36MP0000566_synostosis1.69518530
37MP0004924_abnormal_behavior1.68838142
38MP0005386_behavior/neurological_phenoty1.68838142
39MP0002733_abnormal_thermal_nociception1.67684953
40MP0003121_genomic_imprinting1.64521718
41MP0003950_abnormal_plasma_membrane1.63943220
42MP0000751_myopathy1.62320566
43MP0002234_abnormal_pharynx_morphology1.60351044
44* MP0002882_abnormal_neuron_morphology1.59890705
45MP0001293_anophthalmia1.56527975
46MP0002067_abnormal_sensory_capabilities1.55465781
47MP0006292_abnormal_olfactory_placode1.55083017
48MP0001485_abnormal_pinna_reflex1.54520867
49MP0000534_abnormal_ureter_morphology1.52667600
50MP0002928_abnormal_bile_duct1.51966657
51MP0005409_darkened_coat_color1.51774196
52MP0003011_delayed_dark_adaptation1.50743293
53* MP0002066_abnormal_motor_capabilities/c1.48275545
54MP0002229_neurodegeneration1.47913154
55MP0002638_abnormal_pupillary_reflex1.47655176
56MP0005171_absent_coat_pigmentation1.47331836
57MP0004811_abnormal_neuron_physiology1.45909822
58MP0003137_abnormal_impulse_conducting1.44382986
59MP0002735_abnormal_chemical_nociception1.43324260
60MP0000049_abnormal_middle_ear1.42199773
61MP0009780_abnormal_chondrocyte_physiolo1.36813671
62MP0003942_abnormal_urinary_system1.33559696
63MP0003632_abnormal_nervous_system1.33061252
64MP0002557_abnormal_social/conspecific_i1.32935545
65MP0003631_nervous_system_phenotype1.31481853
66MP0002282_abnormal_trachea_morphology1.31364515
67* MP0002184_abnormal_innervation1.31064318
68MP0003633_abnormal_nervous_system1.30761855
69MP0005248_abnormal_Harderian_gland1.28102420
70MP0002751_abnormal_autonomic_nervous1.27935183
71MP0003879_abnormal_hair_cell1.27629607
72MP0001501_abnormal_sleep_pattern1.25178542
73MP0004145_abnormal_muscle_electrophysio1.24978826
74MP0002837_dystrophic_cardiac_calcinosis1.24191792
75MP0005084_abnormal_gallbladder_morpholo1.23989139
76MP0003787_abnormal_imprinting1.23774865
77MP0005645_abnormal_hypothalamus_physiol1.22160303
78MP0001286_abnormal_eye_development1.20954816
79MP0002152_abnormal_brain_morphology1.20175557
80MP0006276_abnormal_autonomic_nervous1.19046369
81MP0000747_muscle_weakness1.18500050
82MP0002736_abnormal_nociception_after1.17381539
83MP0003119_abnormal_digestive_system1.17125311
84MP0005394_taste/olfaction_phenotype1.16411569
85MP0005499_abnormal_olfactory_system1.16411569
86MP0003122_maternal_imprinting1.15741943
87MP0005646_abnormal_pituitary_gland1.15003833
88MP0003136_yellow_coat_color1.15003448
89MP0001188_hyperpigmentation1.14594943
90MP0009250_abnormal_appendicular_skeleto1.14501308
91MP0002233_abnormal_nose_morphology1.14093941
92MP0008789_abnormal_olfactory_epithelium1.12744986
93MP0004085_abnormal_heartbeat1.09350933
94MP0009053_abnormal_anal_canal1.09176570
95MP0005623_abnormal_meninges_morphology1.08894206
96MP0002752_abnormal_somatic_nervous1.08343322
97MP0000604_amyloidosis1.07447131
98MP0004043_abnormal_pH_regulation1.07284602
99MP0005551_abnormal_eye_electrophysiolog1.06964781
100MP0004036_abnormal_muscle_relaxation1.05986132
101MP0009384_cardiac_valve_regurgitation1.04028309
102MP0003890_abnormal_embryonic-extraembry1.03973251
103MP0001299_abnormal_eye_distance/1.03883094
104MP0001502_abnormal_circadian_rhythm1.01596872
105MP0002938_white_spotting1.00872434
106MP0004215_abnormal_myocardial_fiber1.00772368
107MP0001963_abnormal_hearing_physiology0.98553262
108MP0002116_abnormal_craniofacial_bone0.97832811
109MP0005410_abnormal_fertilization0.94866954
110MP0002932_abnormal_joint_morphology0.94224182
111MP0004858_abnormal_nervous_system0.91441362
112MP0000462_abnormal_digestive_system0.90559831
113MP0000613_abnormal_salivary_gland0.89502633
114MP0003755_abnormal_palate_morphology0.88023967
115MP0000569_abnormal_digit_pigmentation0.86595595
116MP0001984_abnormal_olfaction0.86354769
117MP0000749_muscle_degeneration0.86158551
118MP0000631_abnormal_neuroendocrine_gland0.85956514
119MP0001177_atelectasis0.84485627
120MP0001324_abnormal_eye_pigmentation0.84035362
121MP0004084_abnormal_cardiac_muscle0.82207125
122MP0003937_abnormal_limbs/digits/tail_de0.81405063
123MP0002081_perinatal_lethality0.80569270
124MP0000013_abnormal_adipose_tissue0.80266531
125MP0002277_abnormal_respiratory_mucosa0.78669735
126MP0003938_abnormal_ear_development0.78228460
127MP0002909_abnormal_adrenal_gland0.78122634
128* MP0003861_abnormal_nervous_system0.75854469
129MP0005330_cardiomyopathy0.75762847
130MP0002069_abnormal_eating/drinking_beha0.75405759
131MP0005620_abnormal_muscle_contractility0.74486905
132MP0000026_abnormal_inner_ear0.72566390
133MP0001346_abnormal_lacrimal_gland0.71422232
134MP0010678_abnormal_skin_adnexa0.71065910
135MP0002972_abnormal_cardiac_muscle0.70700340
136MP0001348_abnormal_lacrimal_gland0.69663056
137MP0004133_heterotaxia0.68647813
138MP0000537_abnormal_urethra_morphology0.67409001
139MP0004134_abnormal_chest_morphology0.65022747
140MP0004484_altered_response_of0.64719263
141MP0005195_abnormal_posterior_eye0.64109095
142MP0001943_abnormal_respiration0.62460036
143MP0006072_abnormal_retinal_apoptosis0.61613947
144MP0000003_abnormal_adipose_tissue0.61096876

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)5.84778333
2Hypoplastic pelvis (HP:0008839)5.63055954
3Myokymia (HP:0002411)5.43181423
4Neurofibrillary tangles (HP:0002185)5.40331599
5Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.02750847
6Fibular aplasia (HP:0002990)5.00904252
7Humeroradial synostosis (HP:0003041)4.99952376
8Synostosis involving the elbow (HP:0003938)4.99952376
9Degeneration of the lateral corticospinal tracts (HP:0002314)4.90835548
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.90835548
11Supranuclear gaze palsy (HP:0000605)4.59666889
12Abnormality of the corticospinal tract (HP:0002492)4.44155192
13Cerebral inclusion bodies (HP:0100314)4.31973134
14Oligodactyly (HP:0012165)4.27491976
15Ankle clonus (HP:0011448)4.13739042
16Focal motor seizures (HP:0011153)3.88869915
17Peripheral hypomyelination (HP:0007182)3.74977015
18Spastic gait (HP:0002064)3.63457948
19Dysmetria (HP:0001310)3.44351898
20Termporal pattern (HP:0011008)3.43563609
21Insidious onset (HP:0003587)3.43563609
22Aplasia/hypoplasia of the uterus (HP:0008684)3.41934605
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.35247531
24Adactyly (HP:0009776)3.32790957
25Cerebral hypomyelination (HP:0006808)3.30810875
26Anophthalmia (HP:0000528)3.27645069
27Abnormal ciliary motility (HP:0012262)3.25198261
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.22760194
29Focal seizures (HP:0007359)3.20271543
30Onion bulb formation (HP:0003383)3.17983983
31Intention tremor (HP:0002080)3.15451494
32Symphalangism affecting the phalanges of the hand (HP:0009773)3.09027623
33Abnormality of the pubic bones (HP:0003172)3.03890437
34Sensory axonal neuropathy (HP:0003390)2.99252914
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.98178867
36Absent/shortened dynein arms (HP:0200106)2.98178867
37Broad ribs (HP:0000885)2.95377656
38Abnormal respiratory motile cilium physiology (HP:0012261)2.93276303
39Radial bowing (HP:0002986)2.91344267
40Megalencephaly (HP:0001355)2.91335075
41Septo-optic dysplasia (HP:0100842)2.90540928
42Action tremor (HP:0002345)2.88843924
43Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.84619483
44Pheochromocytoma (HP:0002666)2.81027879
45Limb dystonia (HP:0002451)2.80837840
46Scanning speech (HP:0002168)2.80363342
47Urinary urgency (HP:0000012)2.79821359
48Alacrima (HP:0000522)2.79043610
49Broad-based gait (HP:0002136)2.78862238
50Abdominal situs inversus (HP:0003363)2.77618820
51Abnormality of abdominal situs (HP:0011620)2.77618820
52Hemivertebrae (HP:0002937)2.76017996
53Epileptic encephalopathy (HP:0200134)2.74515876
54Pancreatic fibrosis (HP:0100732)2.72838216
55Hypoplastic nipples (HP:0002557)2.71400745
56Abnormal respiratory motile cilium morphology (HP:0005938)2.68814443
57Abnormal respiratory epithelium morphology (HP:0012253)2.68814443
58Barrel-shaped chest (HP:0001552)2.65481404
59Lower limb muscle weakness (HP:0007340)2.64398164
60Mutism (HP:0002300)2.64167438
61True hermaphroditism (HP:0010459)2.63106779
62Akinesia (HP:0002304)2.62752884
63Rib fusion (HP:0000902)2.60660755
64Polyphagia (HP:0002591)2.59149580
65Aplasia/Hypoplasia of the fibula (HP:0006492)2.58447653
66Visual hallucinations (HP:0002367)2.50951660
67Abnormal auditory evoked potentials (HP:0006958)2.50174449
68Gait imbalance (HP:0002141)2.49372777
69Abnormal finger flexion creases (HP:0006143)2.45825058
70Parakeratosis (HP:0001036)2.45466049
71Urinary bladder sphincter dysfunction (HP:0002839)2.43284273
72Anxiety (HP:0000739)2.40127759
73Abnormality of midbrain morphology (HP:0002418)2.40087844
74Molar tooth sign on MRI (HP:0002419)2.40087844
75Hypoplastic iliac wings (HP:0002866)2.38354306
76Pancreatic cysts (HP:0001737)2.37544154
77Torticollis (HP:0000473)2.36773054
78Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.35917422
79Progressive cerebellar ataxia (HP:0002073)2.34535080
80Cystic liver disease (HP:0006706)2.34427481
81Neuroendocrine neoplasm (HP:0100634)2.33640049
82Retinal dysplasia (HP:0007973)2.30027441
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.29688427
84Esophageal atresia (HP:0002032)2.28990975
85Medial flaring of the eyebrow (HP:0010747)2.28367067
86Sleep apnea (HP:0010535)2.28247898
87Thickened helices (HP:0000391)2.27397403
88Dysdiadochokinesis (HP:0002075)2.27168674
89Nephronophthisis (HP:0000090)2.27090208
90Sclerocornea (HP:0000647)2.26903613
91Meningocele (HP:0002435)2.26740289
92Leukodystrophy (HP:0002415)2.26604734
93Postaxial hand polydactyly (HP:0001162)2.26370268
94Slow saccadic eye movements (HP:0000514)2.26015771
95Maternal diabetes (HP:0009800)2.25587001
96Aplasia involving bones of the upper limbs (HP:0009823)2.25438797
97Aplasia of the phalanges of the hand (HP:0009802)2.25438797
98Aplasia involving bones of the extremities (HP:0009825)2.25438797
99Atonic seizures (HP:0010819)2.25056320
100Specific learning disability (HP:0001328)2.24675886
101Aplasia/Hypoplasia of the ulna (HP:0006495)2.23025139
102Clonus (HP:0002169)2.22438975
103Progressive inability to walk (HP:0002505)2.20062918
104Depression (HP:0000716)2.18977502
105Abnormal eating behavior (HP:0100738)2.18396341
106Decreased lacrimation (HP:0000633)2.16714698
107Skull defect (HP:0001362)2.16390203
108Rhinitis (HP:0012384)2.15101271
109Lissencephaly (HP:0001339)2.14797755
110Prolonged QT interval (HP:0001657)2.14551825
111Abnormal pancreas size (HP:0012094)2.12619574
112CNS hypomyelination (HP:0003429)2.11608871
113Postural instability (HP:0002172)2.11014834
114Poor eye contact (HP:0000817)2.10970617
115Impaired vibration sensation in the lower limbs (HP:0002166)2.10967811
116Sudden death (HP:0001699)2.10922424
117Bowing of the arm (HP:0006488)2.10726343
118Bowed forearm bones (HP:0003956)2.10726343
119Muscle fiber splitting (HP:0003555)2.09923322
120Foot dorsiflexor weakness (HP:0009027)2.08483337
121Poor speech (HP:0002465)2.07199682
122Hyperventilation (HP:0002883)2.06969678
123Morphological abnormality of the pyramidal tract (HP:0002062)2.06388133
124Anteriorly placed anus (HP:0001545)2.05733400
125Synostosis involving bones of the lower limbs (HP:0009138)2.05296788
126Synostosis involving bones of the feet (HP:0009140)2.05296788
127Tarsal synostosis (HP:0008368)2.04219813
128Spastic tetraparesis (HP:0001285)2.03725185
129Congenital stationary night blindness (HP:0007642)2.03641263
130Patellar aplasia (HP:0006443)2.03572699
131Short foot (HP:0001773)2.03333195
132Abnormality of the foot musculature (HP:0001436)2.02989024
133Focal dystonia (HP:0004373)2.02011911
134Excessive salivation (HP:0003781)2.01964586
135Drooling (HP:0002307)2.01964586
136Muscle hypertrophy of the lower extremities (HP:0008968)2.01786525
137Truncal ataxia (HP:0002078)2.01684362
138Absent septum pellucidum (HP:0001331)2.01020614
139Congenital primary aphakia (HP:0007707)2.01004635
140Bowel incontinence (HP:0002607)2.00142477
141Dialeptic seizures (HP:0011146)1.97856113
142Neuronal loss in central nervous system (HP:0002529)1.97853122
143Ulnar deviation of finger (HP:0009465)1.97667904
144Pachygyria (HP:0001302)1.96870705
145Annular pancreas (HP:0001734)1.95232290
146Split foot (HP:0001839)1.94907847
147Spastic tetraplegia (HP:0002510)1.94646554
148Generalized tonic-clonic seizures (HP:0002069)1.94090751
149Craniofacial dystonia (HP:0012179)1.93079447
150Increased circulating renin level (HP:0000848)1.92773204
151Hemiparesis (HP:0001269)1.92603960
152Nephrogenic diabetes insipidus (HP:0009806)1.92514524
153Choreoathetosis (HP:0001266)1.91259921
154Hammertoe (HP:0001765)1.91014380
155Genital tract atresia (HP:0001827)1.90528865
156Generalized myoclonic seizures (HP:0002123)1.90526538
157Clumsiness (HP:0002312)1.90485642
158Renal dysplasia (HP:0000110)1.89838898
159Abnormal number of incisors (HP:0011064)1.89782339
160Aplasia/Hypoplasia of the patella (HP:0006498)1.89241216
161Abnormal social behavior (HP:0012433)1.88901073
162Impaired social interactions (HP:0000735)1.88901073
163Gaze-evoked nystagmus (HP:0000640)1.87222286
164Anencephaly (HP:0002323)1.87017073
165Abnormality of the diencephalon (HP:0010662)1.86338145
166Rapidly progressive (HP:0003678)1.83860927
167Hyporeflexia of lower limbs (HP:0002600)1.83493254
168Optic nerve hypoplasia (HP:0000609)1.83187058
169Absence seizures (HP:0002121)1.82425535
170Exercise-induced myalgia (HP:0003738)1.81783406
171Agitation (HP:0000713)1.81339510
172Overriding aorta (HP:0002623)1.81270672
173Vaginal atresia (HP:0000148)1.81258843
174Aplasia involving forearm bones (HP:0009822)1.81001932
175Absent forearm bone (HP:0003953)1.81001932
176Scrotal hypoplasia (HP:0000046)1.80871659
177Abnormality of the renal medulla (HP:0100957)1.80853070
178Cerebral hemorrhage (HP:0001342)1.80851383
179Abnormal large intestine physiology (HP:0012700)1.80531962
180Abnormal EKG (HP:0003115)1.80004039
181Ventricular fibrillation (HP:0001663)1.79232238
182Decreased motor nerve conduction velocity (HP:0003431)1.79002233
183Genetic anticipation (HP:0003743)1.78049262
184Epileptiform EEG discharges (HP:0011182)1.77971686
185Difficulty running (HP:0009046)1.77376600
186Hypoplasia of the radius (HP:0002984)1.74240973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.01984672
2MARK13.81551400
3OXSR12.95312291
4EPHA42.88025382
5MAPK152.86597197
6PKN12.33268471
7MAP3K92.26361525
8EPHB22.24718859
9UHMK12.14843132
10NTRK32.14435806
11PAK62.13974799
12BCR2.04765764
13CDK192.04568486
14NTRK11.99359516
15PHKG21.95094452
16PHKG11.95094452
17NTRK21.89070728
18FGFR21.80171760
19LIMK11.77843328
20PRPF4B1.75073249
21TNIK1.71138151
22WNK41.69980441
23BMPR1B1.69377827
24MINK11.65689536
25ICK1.62228685
26WNK31.59898095
27EPHB11.54307594
28KSR21.53511512
29PNCK1.50743643
30CAMK2B1.45594776
31PRKD31.43474803
32CDK51.40631730
33WNK11.40316220
34TYRO31.39813007
35CSNK1G31.35897306
36DYRK1B1.35533248
37CSNK1G21.33742289
38ROCK21.31929192
39MAPKAPK51.31592384
40SGK2231.29410049
41SGK4941.29410049
42CSNK1A1L1.28827799
43MAP3K41.28675044
44DYRK21.27828084
45KSR11.27357810
46PAK31.26847524
47CASK1.23191883
48CAMK2D1.19649092
49MAPK131.17059263
50NEK61.16432032
51STK38L1.15804905
52CDK141.09530489
53MARK21.07975869
54CAMK2A1.05921455
55CDK151.02897066
56CDK181.02654303
57DAPK21.01163065
58EPHA31.01032141
59SIK10.96302730
60DMPK0.95651697
61MET0.95329104
62CSNK1G10.95099567
63CDK11A0.90678002
64TESK20.90193031
65LATS20.89626379
66CAMK2G0.88129079
67MAP2K70.87823359
68TGFBR10.87265124
69ERBB20.81009063
70MAP3K100.80718648
71FGR0.80701824
72ARAF0.80677187
73PRKD10.79060595
74DYRK30.78753738
75SGK20.78652920
76PRKCH0.77551434
77STK110.77177845
78PRKCE0.73194551
79PINK10.72217074
80LMTK20.69843911
81CAMKK10.69291259
82ADRBK20.68681457
83PDPK10.67646740
84FYN0.66955907
85CLK10.64736585
86MUSK0.63581457
87PLK20.63280078
88ERBB30.62859132
89PRKCG0.62552538
90MAP3K20.62154515
91FES0.60669685
92DAPK30.58956376
93DYRK1A0.58757639
94CAMK1D0.58110844
95IRAK20.57763818
96GRK50.56792635
97MAP3K130.56452104
98RIPK10.55572381
99PBK0.55231869
100AURKA0.54492475
101MAP2K40.52728467
102PRKCZ0.50429003
103GRK10.50104826
104LATS10.49797669
105ALK0.49794977
106ADRBK10.48804524
107CAMK10.48755608
108GRK70.48030931
109AKT30.47605673
110SGK10.47379613
111PRKCQ0.46481074
112WEE10.45846539
113SIK20.45140539
114ROCK10.45100284
115PRKACA0.45052247
116CAMK1G0.45017726
117PRKG10.43767740
118RET0.43426232
119CSNK1D0.43292819
120DDR20.42698787
121PDK10.41951037
122PASK0.41366178
123RPS6KA20.41317964
124MAPK100.40476962
125TSSK60.39694998
126MAP3K70.39691815
127PTK2B0.39464224
128CAMKK20.38606654
129CDC42BPA0.38372385
130ILK0.38235466
131PRKACB0.38213297
132CSNK1E0.37695072
133INSRR0.37427484
134CAMK40.35725997
135RPS6KA30.35444426
136BRD40.35238398
137CDK80.34550938
138PRKCB0.30749417
139SGK30.30061585
140PRKAA10.29551436
141MAP3K110.29525076
142NME10.28942726

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.07194152
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.86658737
3GABAergic synapse_Homo sapiens_hsa047272.51568053
4Nicotine addiction_Homo sapiens_hsa050332.47139334
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36850564
6Glutamatergic synapse_Homo sapiens_hsa047242.32508148
7Morphine addiction_Homo sapiens_hsa050322.19699793
8Circadian entrainment_Homo sapiens_hsa047132.18173533
9* Axon guidance_Homo sapiens_hsa043602.14073651
10Synaptic vesicle cycle_Homo sapiens_hsa047212.13651319
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12438017
12Fatty acid elongation_Homo sapiens_hsa000622.05712239
13Olfactory transduction_Homo sapiens_hsa047401.95016309
14Steroid biosynthesis_Homo sapiens_hsa001001.79939561
15Dopaminergic synapse_Homo sapiens_hsa047281.77009091
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.74051920
17Cocaine addiction_Homo sapiens_hsa050301.72375498
18Long-term potentiation_Homo sapiens_hsa047201.69502397
19Cardiac muscle contraction_Homo sapiens_hsa042601.66442088
20Hippo signaling pathway_Homo sapiens_hsa043901.66163910
21Amphetamine addiction_Homo sapiens_hsa050311.65439728
22Serotonergic synapse_Homo sapiens_hsa047261.64598144
23Salivary secretion_Homo sapiens_hsa049701.62044296
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60527900
25Cholinergic synapse_Homo sapiens_hsa047251.60069358
26Nitrogen metabolism_Homo sapiens_hsa009101.57852240
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.56827104
28Gastric acid secretion_Homo sapiens_hsa049711.56136501
29Ether lipid metabolism_Homo sapiens_hsa005651.55727838
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55402505
31Long-term depression_Homo sapiens_hsa047301.52291209
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50812169
33Ribosome_Homo sapiens_hsa030101.44259337
34Gap junction_Homo sapiens_hsa045401.36165501
35Renin secretion_Homo sapiens_hsa049241.32297032
36Insulin secretion_Homo sapiens_hsa049111.28960265
37Oxidative phosphorylation_Homo sapiens_hsa001901.26205499
38Oxytocin signaling pathway_Homo sapiens_hsa049211.24369386
39Notch signaling pathway_Homo sapiens_hsa043301.23790390
40Renal cell carcinoma_Homo sapiens_hsa052111.21031101
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20318722
42Taste transduction_Homo sapiens_hsa047421.20035948
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17667970
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17232706
45Butanoate metabolism_Homo sapiens_hsa006501.15919841
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15219656
47Alzheimers disease_Homo sapiens_hsa050101.14801285
48Parkinsons disease_Homo sapiens_hsa050121.13751623
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13253853
50Calcium signaling pathway_Homo sapiens_hsa040201.12348202
51cAMP signaling pathway_Homo sapiens_hsa040241.09042287
52Dilated cardiomyopathy_Homo sapiens_hsa054141.08898367
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08792933
54ErbB signaling pathway_Homo sapiens_hsa040121.05927010
55Collecting duct acid secretion_Homo sapiens_hsa049661.03931901
56Protein export_Homo sapiens_hsa030601.01853278
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.01152109
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.99076438
59Dorso-ventral axis formation_Homo sapiens_hsa043200.96829642
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95766214
61GnRH signaling pathway_Homo sapiens_hsa049120.95598975
62Vibrio cholerae infection_Homo sapiens_hsa051100.94420046
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94213569
64Melanogenesis_Homo sapiens_hsa049160.91846407
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89362467
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88091497
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.87264379
68Ras signaling pathway_Homo sapiens_hsa040140.85224974
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82071885
70Tight junction_Homo sapiens_hsa045300.81656008
71Endocytosis_Homo sapiens_hsa041440.79918218
72Estrogen signaling pathway_Homo sapiens_hsa049150.79275244
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78647533
74Phototransduction_Homo sapiens_hsa047440.77817264
75Vitamin B6 metabolism_Homo sapiens_hsa007500.76937642
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76855722
77Type II diabetes mellitus_Homo sapiens_hsa049300.72717390
78Choline metabolism in cancer_Homo sapiens_hsa052310.70207085
79Pancreatic secretion_Homo sapiens_hsa049720.69665998
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67772348
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67621236
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67129094
83Sphingolipid metabolism_Homo sapiens_hsa006000.66624352
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66554898
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66061031
86MAPK signaling pathway_Homo sapiens_hsa040100.62779325
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62264691
88Glioma_Homo sapiens_hsa052140.61900781
89Ovarian steroidogenesis_Homo sapiens_hsa049130.60114543
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58198686
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58112385
92Hedgehog signaling pathway_Homo sapiens_hsa043400.57286800
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56251608
94Alcoholism_Homo sapiens_hsa050340.54804569
95Prion diseases_Homo sapiens_hsa050200.54560092
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54091080
97Bile secretion_Homo sapiens_hsa049760.53444023
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53432850
99Huntingtons disease_Homo sapiens_hsa050160.52893187
100Wnt signaling pathway_Homo sapiens_hsa043100.52273036
101Rap1 signaling pathway_Homo sapiens_hsa040150.50309425
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48192770
103Pathways in cancer_Homo sapiens_hsa052000.47474719
104Oocyte meiosis_Homo sapiens_hsa041140.46588999
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45424509
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44403011
107VEGF signaling pathway_Homo sapiens_hsa043700.44056941
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.42574319
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40318848
110TGF-beta signaling pathway_Homo sapiens_hsa043500.39627251
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38770923
112Sulfur metabolism_Homo sapiens_hsa009200.38613788
113Linoleic acid metabolism_Homo sapiens_hsa005910.37937433
114Thyroid hormone synthesis_Homo sapiens_hsa049180.36877801
115Tryptophan metabolism_Homo sapiens_hsa003800.36481816
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36251575
117Propanoate metabolism_Homo sapiens_hsa006400.33449662
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32076195
119Chemokine signaling pathway_Homo sapiens_hsa040620.30659982
120AMPK signaling pathway_Homo sapiens_hsa041520.29343375
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28845604
122Protein digestion and absorption_Homo sapiens_hsa049740.28760594
123Fatty acid metabolism_Homo sapiens_hsa012120.27310440
124Inositol phosphate metabolism_Homo sapiens_hsa005620.27124971
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25118443
126Glycerolipid metabolism_Homo sapiens_hsa005610.23267367

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