EFNB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)5.16121551
2Notch signaling involved in heart development (GO:0061314)4.97398606
3ventricular trabecula myocardium morphogenesis (GO:0003222)4.51876013
4heart valve formation (GO:0003188)4.11642781
5desmosome organization (GO:0002934)4.11421518
6hippo signaling (GO:0035329)3.75669825
7heart trabecula morphogenesis (GO:0061384)3.73418405
8dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.71415685
9cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.66893099
10neuron projection extension involved in neuron projection guidance (GO:1902284)3.62421476
11axon extension involved in axon guidance (GO:0048846)3.62421476
12gap junction assembly (GO:0016264)3.58580014
13endothelial cell differentiation (GO:0045446)3.48299346
14planar cell polarity pathway involved in neural tube closure (GO:0090179)3.48012000
15hemidesmosome assembly (GO:0031581)3.37606797
16chondrocyte proliferation (GO:0035988)3.35282408
17negative regulation of axon extension involved in axon guidance (GO:0048843)3.31467298
18negative regulation of cell fate specification (GO:0009996)3.26359910
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.24939753
20apical protein localization (GO:0045176)3.22856377
21negative regulation of catenin import into nucleus (GO:0035414)3.22038190
22neuron recognition (GO:0008038)3.20206713
23vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.18542802
24paraxial mesoderm development (GO:0048339)3.17007951
25regulation of axon extension involved in axon guidance (GO:0048841)3.15764769
26G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.15529392
27morphogenesis of an epithelial sheet (GO:0002011)3.15514862
28endothelial tube morphogenesis (GO:0061154)3.12193433
29morphogenesis of an endothelium (GO:0003159)3.12193433
30lymphangiogenesis (GO:0001946)3.11098198
31layer formation in cerebral cortex (GO:0021819)3.10016091
32regulation of cardioblast differentiation (GO:0051890)3.07580326
33trabecula morphogenesis (GO:0061383)3.06722354
34plasma membrane repair (GO:0001778)3.04838064
35* cell migration involved in sprouting angiogenesis (GO:0002042)3.03671326
36lateral sprouting from an epithelium (GO:0060601)3.03366071
37regulation of transforming growth factor beta2 production (GO:0032909)2.98884830
38negative regulation of chondrocyte differentiation (GO:0032331)2.97967302
39* lymph vessel development (GO:0001945)2.90609364
40artery development (GO:0060840)2.87966233
41regulation of axon guidance (GO:1902667)2.87757278
42peptidyl-tyrosine autophosphorylation (GO:0038083)2.87687402
43keratinocyte proliferation (GO:0043616)2.86316128
44negative regulation of axon guidance (GO:1902668)2.85327988
45coronary vasculature morphogenesis (GO:0060977)2.84653262
46endothelial cell morphogenesis (GO:0001886)2.81132424
47mesodermal cell differentiation (GO:0048333)2.80726385
48polarized epithelial cell differentiation (GO:0030859)2.80593617
49regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.80255635
50embryonic foregut morphogenesis (GO:0048617)2.78533603
51blood vessel maturation (GO:0001955)2.77213307
52notochord development (GO:0030903)2.76481611
53lung-associated mesenchyme development (GO:0060484)2.74731598
54surfactant homeostasis (GO:0043129)2.73554916
55establishment of planar polarity (GO:0001736)2.72855431
56establishment of tissue polarity (GO:0007164)2.72855431
57cytoskeletal anchoring at plasma membrane (GO:0007016)2.72164970
58wound healing, spreading of epidermal cells (GO:0035313)2.71032354
59regulation of cell fate specification (GO:0042659)2.70805127
60cell surface receptor signaling pathway involved in heart development (GO:0061311)2.70525048
61cell adhesion mediated by integrin (GO:0033627)2.70270720
62sprouting angiogenesis (GO:0002040)2.69816574
63neural crest cell development (GO:0014032)2.69498284
64semaphorin-plexin signaling pathway (GO:0071526)2.68340064
65asymmetric protein localization (GO:0008105)2.66441810
66glial cell proliferation (GO:0014009)2.65452038
67lens morphogenesis in camera-type eye (GO:0002089)2.65091417
68regulation of heart morphogenesis (GO:2000826)2.64811603
69camera-type eye morphogenesis (GO:0048593)2.64497874
70axon extension (GO:0048675)2.63739057
71regulation of catenin import into nucleus (GO:0035412)2.63686928
72non-canonical Wnt signaling pathway (GO:0035567)2.61237514
73outer ear morphogenesis (GO:0042473)2.58617883
74regulation of vasculogenesis (GO:2001212)2.58252275
75convergent extension (GO:0060026)2.57740497
76* ephrin receptor signaling pathway (GO:0048013)2.56561789
77negative regulation of activin receptor signaling pathway (GO:0032926)2.54578951
78axonal fasciculation (GO:0007413)2.54301665
79Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54007523
80presynaptic membrane assembly (GO:0097105)2.51548426
81sequestering of extracellular ligand from receptor (GO:0035581)2.50697347
82craniofacial suture morphogenesis (GO:0097094)2.49908864
83neuron remodeling (GO:0016322)2.49368702
84gastrulation with mouth forming second (GO:0001702)2.48510413
85bundle of His cell to Purkinje myocyte communication (GO:0086069)2.48108116
86endothelial cell chemotaxis (GO:0035767)2.48053330
87endocardial cushion morphogenesis (GO:0003203)2.47989010
88regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.47185626
89ganglion development (GO:0061548)2.46891144
90neuronal stem cell maintenance (GO:0097150)2.45934631
91chemical homeostasis within a tissue (GO:0048875)2.45412628
92atrial cardiac muscle cell action potential (GO:0086014)2.45301978
93embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44926984
94regulation of glomerular filtration (GO:0003093)2.44842591
95anatomical structure arrangement (GO:0048532)2.44842513
96cardiac epithelial to mesenchymal transition (GO:0060317)2.44782473
97establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.44380104
98neuron projection extension (GO:1990138)2.44276670
99mesenchyme morphogenesis (GO:0072132)2.44171060
100regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.44086092
101regulation of establishment of planar polarity (GO:0090175)2.44050697
102heart valve morphogenesis (GO:0003179)2.42509622
103establishment of nucleus localization (GO:0040023)2.42506546
104substrate-dependent cell migration (GO:0006929)2.42145790
105mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.41495023
106endodermal cell differentiation (GO:0035987)2.41457591
107positive regulation of mesenchymal cell proliferation (GO:0002053)2.41306222
108negative regulation of cartilage development (GO:0061037)2.40749114
109cell-substrate junction assembly (GO:0007044)2.40718741
110cerebral cortex cell migration (GO:0021795)2.40609942
111vascular endothelial growth factor signaling pathway (GO:0038084)2.40337011
112respiratory tube development (GO:0030323)2.38911821
113vasculogenesis (GO:0001570)2.38874881
114* negative regulation of keratinocyte proliferation (GO:0010839)2.38021256
115negative regulation of cell fate commitment (GO:0010454)2.37609756
116regulation of mesenchymal cell proliferation (GO:0010464)2.36872457
117cartilage morphogenesis (GO:0060536)2.36538183
118renal filtration (GO:0097205)2.36435546
119cochlea morphogenesis (GO:0090103)2.35441543
120regulation of hippo signaling (GO:0035330)2.35343869
121cell migration in hindbrain (GO:0021535)2.34644535
122body morphogenesis (GO:0010171)2.34362426
123metanephric mesenchyme development (GO:0072075)2.34042554
124mesenchymal cell development (GO:0014031)2.33472573
125positive regulation of neuroblast proliferation (GO:0002052)2.32887553
126wound healing, spreading of cells (GO:0044319)2.32809635
127negative regulation of embryonic development (GO:0045992)2.32586330
128embryonic body morphogenesis (GO:0010172)2.32490590
129glomerular basement membrane development (GO:0032836)2.32359350
130cardiac muscle cell proliferation (GO:0060038)2.30897115
131patterning of blood vessels (GO:0001569)2.30490727
132regulation of tight junction assembly (GO:2000810)2.30417168
133embryonic heart tube development (GO:0035050)2.30293603
134bone trabecula formation (GO:0060346)2.30164504
135adherens junction organization (GO:0034332)2.29685974
136cerebral cortex radially oriented cell migration (GO:0021799)2.29599926
137limb bud formation (GO:0060174)2.29386964
138insulin-like growth factor receptor signaling pathway (GO:0048009)2.28495472
139organ formation (GO:0048645)2.28142847
140basement membrane organization (GO:0071711)2.27412940
141collagen fibril organization (GO:0030199)2.27337325
142dorsal/ventral axis specification (GO:0009950)2.25313246
143epithelial to mesenchymal transition (GO:0001837)2.25303768
144epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.23220646
145retina vasculature morphogenesis in camera-type eye (GO:0061299)2.22780948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.02156968
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.20726822
3* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52782911
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18108819
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18108819
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.11595289
7* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10504999
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07617540
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05105230
10* EED_16625203_ChIP-ChIP_MESCs_Mouse2.04190783
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99556251
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98566312
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91997037
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91578854
15* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90486417
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89926300
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.88986909
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.88595019
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86847559
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79005320
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.77892073
22* RNF2_27304074_Chip-Seq_ESCs_Mouse1.76199148
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.75642910
24* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74570730
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74248986
26* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73674273
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71803887
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70503314
29TP53_16413492_ChIP-PET_HCT116_Human1.68227704
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66265215
31AR_21572438_ChIP-Seq_LNCaP_Human1.65933570
32TP53_18474530_ChIP-ChIP_U2OS_Human1.65340807
33AHR_22903824_ChIP-Seq_MCF-7_Human1.63784770
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.63581697
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62295627
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61752390
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.58617291
38* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58535716
39EZH2_22144423_ChIP-Seq_EOC_Human1.58423363
40* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56993217
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56489897
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54875398
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.52002828
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50516549
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.50265938
46* EZH2_27294783_Chip-Seq_ESCs_Mouse1.50065572
47CJUN_26792858_Chip-Seq_BT549_Human1.49808709
48* ISL1_27105846_Chip-Seq_CPCs_Mouse1.48684093
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.44699343
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.44677546
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.43934289
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41635725
53* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40121832
54* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38089660
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33424196
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33424196
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.32644512
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.30524070
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28992022
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28435996
61BRD4_25478319_ChIP-Seq_HGPS_Human1.27110713
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25429180
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25317385
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24986686
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.23968103
66* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23937506
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23362823
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22776555
69* AR_21909140_ChIP-Seq_LNCAP_Human1.22232333
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22103589
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22093091
72* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21064583
73KDM2B_26808549_Chip-Seq_K562_Human1.19121897
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18615577
75* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18541095
76* CBX2_27304074_Chip-Seq_ESCs_Mouse1.18277594
77* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17578738
78* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17531857
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.17076074
80* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17068964
81CLOCK_20551151_ChIP-Seq_293T_Human1.15437020
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15110375
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14376504
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14101290
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.13600749
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13180240
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13027522
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.12672743
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12352326
90TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11883634
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11521828
92POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11466279
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11156862
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10922306
95RXR_22108803_ChIP-Seq_LS180_Human1.10483383
96* RNF2_27304074_Chip-Seq_NSC_Mouse1.09764281
97GBX2_23144817_ChIP-Seq_PC3_Human1.09491919
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.09054532
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08236888
100* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07487446
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06924542
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06845773
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06638087
104DROSHA_22980978_ChIP-Seq_HELA_Human1.06454523
105CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05869118
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.05067742
107* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03968374
108SOX2_20726797_ChIP-Seq_SW620_Human1.03561446
109* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03272128
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02657083
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02132874
112* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00803501
113* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00803501
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00677018
115* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99289009
116SMAD3_21741376_ChIP-Seq_EPCs_Human0.98785732
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97572596
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.96613524
119* KLF5_25053715_ChIP-Seq_YYC3_Human0.95715970
120BCAT_22108803_ChIP-Seq_LS180_Human0.95640691
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94773411
122SMAD4_21799915_ChIP-Seq_A2780_Human0.92354135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.09804123
2MP0003941_abnormal_skin_development2.99734530
3MP0010234_abnormal_vibrissa_follicle2.91948903
4MP0010030_abnormal_orbit_morphology2.78372538
5* MP0000537_abnormal_urethra_morphology2.70021880
6MP0005623_abnormal_meninges_morphology2.59039741
7MP0003385_abnormal_body_wall2.36334829
8MP0005409_darkened_coat_color2.31169547
9MP0005275_abnormal_skin_tensile2.13073440
10MP0008789_abnormal_olfactory_epithelium2.05834365
11* MP0003705_abnormal_hypodermis_morpholog2.03451449
12* MP0009053_abnormal_anal_canal2.00432285
13MP0009250_abnormal_appendicular_skeleto1.97154882
14MP0003755_abnormal_palate_morphology1.90232586
15MP0000049_abnormal_middle_ear1.84372394
16MP0002233_abnormal_nose_morphology1.79635607
17* MP0010368_abnormal_lymphatic_system1.78124486
18MP0002234_abnormal_pharynx_morphology1.78093327
19MP0005248_abnormal_Harderian_gland1.77609339
20MP0009780_abnormal_chondrocyte_physiolo1.73684718
21MP0002249_abnormal_larynx_morphology1.73077967
22MP0010352_gastrointestinal_tract_polyps1.72768933
23MP0002098_abnormal_vibrissa_morphology1.71850407
24MP0000534_abnormal_ureter_morphology1.71361914
25MP0000762_abnormal_tongue_morphology1.70548110
26MP0005394_taste/olfaction_phenotype1.69883128
27MP0005499_abnormal_olfactory_system1.69883128
28MP0005257_abnormal_intraocular_pressure1.68534040
29MP0006292_abnormal_olfactory_placode1.66920500
30MP0010678_abnormal_skin_adnexa1.66815874
31* MP0001879_abnormal_lymphatic_vessel1.66423831
32MP0001346_abnormal_lacrimal_gland1.65531062
33MP0000579_abnormal_nail_morphology1.65008429
34MP0003937_abnormal_limbs/digits/tail_de1.63789902
35MP0002796_impaired_skin_barrier1.63478403
36MP0008438_abnormal_cutaneous_collagen1.62108542
37MP0000566_synostosis1.61910859
38MP0003942_abnormal_urinary_system1.59412696
39MP0009384_cardiac_valve_regurgitation1.56411708
40* MP0003935_abnormal_craniofacial_develop1.56083152
41MP0002282_abnormal_trachea_morphology1.52733319
42* MP0005367_renal/urinary_system_phenotyp1.52530940
43* MP0000516_abnormal_urinary_system1.52530940
44MP0000383_abnormal_hair_follicle1.50750652
45MP0003566_abnormal_cell_adhesion1.48536763
46MP0003115_abnormal_respiratory_system1.48028474
47MP0001849_ear_inflammation1.46389874
48MP0000428_abnormal_craniofacial_morphol1.43548978
49MP0001299_abnormal_eye_distance/1.43213865
50MP0005076_abnormal_cell_differentiation1.39008379
51MP0005503_abnormal_tendon_morphology1.36838082
52* MP0003119_abnormal_digestive_system1.31936023
53* MP0000778_abnormal_nervous_system1.28494277
54MP0002932_abnormal_joint_morphology1.27825120
55MP0005508_abnormal_skeleton_morphology1.26649799
56MP0000647_abnormal_sebaceous_gland1.24662234
57MP0002896_abnormal_bone_mineralization1.24087179
58MP0002254_reproductive_system_inflammat1.23745950
59MP0004858_abnormal_nervous_system1.23347813
60MP0002116_abnormal_craniofacial_bone1.23074261
61MP0003283_abnormal_digestive_organ1.22676079
62MP0003091_abnormal_cell_migration1.22302356
63MP0000767_abnormal_smooth_muscle1.20994451
64MP0003122_maternal_imprinting1.20318584
65MP0000432_abnormal_head_morphology1.19420652
66MP0000733_abnormal_muscle_development1.18852180
67MP0006054_spinal_hemorrhage1.18010770
68MP0004859_abnormal_synaptic_plasticity1.17999146
69MP0002060_abnormal_skin_morphology1.17824102
70MP0002697_abnormal_eye_size1.16588422
71MP0006138_congestive_heart_failure1.16376006
72* MP0005187_abnormal_penis_morphology1.14689780
73MP0000467_abnormal_esophagus_morphology1.09680621
74MP0004270_analgesia1.08942129
75MP0003567_abnormal_fetal_cardiomyocyte1.08122374
76MP0001340_abnormal_eyelid_morphology1.07858395
77* MP0002925_abnormal_cardiovascular_devel1.07420481
78MP0002177_abnormal_outer_ear1.05270400
79MP0003279_aneurysm1.03249467
80MP0005197_abnormal_uvea_morphology1.03087886
81MP0001958_emphysema1.02195849
82MP0001286_abnormal_eye_development1.01858028
83MP0000163_abnormal_cartilage_morphology0.99999032
84MP0003828_pulmonary_edema0.98884217
85MP0005595_abnormal_vascular_smooth0.97757594
86MP0000678_abnormal_parathyroid_gland0.96000456
87* MP0002085_abnormal_embryonic_tissue0.94552914
88MP0000427_abnormal_hair_cycle0.94525848
89MP0002109_abnormal_limb_morphology0.93858075
90* MP0000377_abnormal_hair_follicle0.92693214
91MP0003938_abnormal_ear_development0.91280907
92MP0000462_abnormal_digestive_system0.91178868
93* MP0001614_abnormal_blood_vessel0.91115156
94MP0001177_atelectasis0.89675240
95MP0003890_abnormal_embryonic-extraembry0.89495233
96* MP0001216_abnormal_epidermal_layer0.89158270
97MP0002009_preneoplasia0.88154485
98MP0003453_abnormal_keratinocyte_physiol0.87447820
99MP0002938_white_spotting0.86280000
100* MP0003861_abnormal_nervous_system0.85052052
101MP0001915_intracranial_hemorrhage0.84575713
102* MP0002084_abnormal_developmental_patter0.84100990
103MP0001784_abnormal_fluid_regulation0.84100376
104* MP0002081_perinatal_lethality0.84014744
105MP0002092_abnormal_eye_morphology0.83822265
106MP0002295_abnormal_pulmonary_circulatio0.82602373
107MP0002115_abnormal_skeleton_extremities0.79777302
108MP0002111_abnormal_tail_morphology0.79649716
109* MP0002152_abnormal_brain_morphology0.79189883
110* MP0005501_abnormal_skin_physiology0.78776607
111MP0001293_anophthalmia0.78698370
112MP0003943_abnormal_hepatobiliary_system0.77970838
113* MP0003984_embryonic_growth_retardation0.77282682
114* MP0010771_integument_phenotype0.77128077
115MP0002089_abnormal_postnatal_growth/wei0.76893888
116MP0004197_abnormal_fetal_growth/weight/0.76729170
117MP0004484_altered_response_of0.76529178
118* MP0002128_abnormal_blood_circulation0.75592204
119MP0005193_abnormal_anterior_eye0.75433010
120* MP0002086_abnormal_extraembryonic_tissu0.74899336
121* MP0002088_abnormal_embryonic_growth/wei0.73912972
122* MP0005380_embryogenesis_phenotype0.72936055
123* MP0001672_abnormal_embryogenesis/_devel0.72936055
124MP0002114_abnormal_axial_skeleton0.69112044

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)4.04365124
2Short 4th metacarpal (HP:0010044)3.33557503
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.33557503
4Protrusio acetabuli (HP:0003179)2.87550605
5Atrophic scars (HP:0001075)2.66138143
6Abnormality of the ischium (HP:0003174)2.62907301
7Asymmetry of the thorax (HP:0001555)2.59672248
8Vertebral arch anomaly (HP:0008438)2.58295377
9Right ventricular cardiomyopathy (HP:0011663)2.55029185
10Abnormality of the 4th metacarpal (HP:0010012)2.51600345
11Absent eyebrow (HP:0002223)2.48873002
12Cutaneous finger syndactyly (HP:0010554)2.47827391
13Bronchomalacia (HP:0002780)2.47192073
14Ulnar bowing (HP:0003031)2.44825846
15Vitreoretinal degeneration (HP:0000655)2.42559426
16Coronal craniosynostosis (HP:0004440)2.41574552
17Abnormality of the nasal septum (HP:0000419)2.39889614
18Premature rupture of membranes (HP:0001788)2.39336723
19Abnormality of the lower motor neuron (HP:0002366)2.38759348
20High anterior hairline (HP:0009890)2.24998198
21Broad metatarsal (HP:0001783)2.21522974
22Natal tooth (HP:0000695)2.18246459
23Hypoplasia of the iris (HP:0007676)2.14020869
24Fragile nails (HP:0001808)2.13993103
25Overgrowth (HP:0001548)2.13219856
26Milia (HP:0001056)2.12952335
27Rectal prolapse (HP:0002035)2.12127468
28Cutaneous syndactyly (HP:0012725)2.09089367
29Abnormality of the aortic arch (HP:0012303)2.08805137
30Capillary hemangiomas (HP:0005306)2.08243973
31Abnormality of the phalanges of the hallux (HP:0010057)2.07740253
32Vertebral clefting (HP:0008428)2.06756856
33Vertebral hypoplasia (HP:0008417)2.05562637
34Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.05562637
35Morphological abnormality of the middle ear (HP:0008609)2.05560423
36Advanced eruption of teeth (HP:0006288)2.05471938
37Trigonocephaly (HP:0000243)2.04871950
38Wide anterior fontanel (HP:0000260)2.03493479
39Down-sloping shoulders (HP:0200021)2.03252746
40Turricephaly (HP:0000262)2.00442878
41Midline defect of the nose (HP:0004122)1.99964142
42Ankyloglossia (HP:0010296)1.99305662
43Lymphangioma (HP:0100764)1.99101362
44Buphthalmos (HP:0000557)1.99070257
45Wrist flexion contracture (HP:0001239)1.98521158
46Vascular tortuosity (HP:0004948)1.97884819
47Cerebral aneurysm (HP:0004944)1.95016814
48Onycholysis (HP:0001806)1.93798057
49Subacute progressive viral hepatitis (HP:0006572)1.93674950
50Aqueductal stenosis (HP:0002410)1.93549010
51Arterial tortuosity (HP:0005116)1.91377079
52Hypoplastic labia majora (HP:0000059)1.91374093
53Neonatal short-limb short stature (HP:0008921)1.90509311
54Exotropia (HP:0000577)1.89578967
55Abnormality of dentin (HP:0010299)1.89149715
56Abnormality of the distal phalanx of the thumb (HP:0009617)1.88520817
57Thin ribs (HP:0000883)1.87921931
58Hepatoblastoma (HP:0002884)1.85543312
59Fragile skin (HP:0001030)1.83575031
60Bladder diverticulum (HP:0000015)1.83418079
61Broad thumb (HP:0011304)1.83129118
62Woolly hair (HP:0002224)1.81580028
63Pterygium (HP:0001059)1.81481533
64Deviation of the hallux (HP:0010051)1.81379519
65Aortic aneurysm (HP:0004942)1.80296869
66Tibial bowing (HP:0002982)1.79944300
67Obstructive sleep apnea (HP:0002870)1.79369828
68Hypoplastic ischia (HP:0003175)1.78738342
69Lip pit (HP:0100267)1.78286500
70Mitral valve prolapse (HP:0001634)1.77713306
71Split foot (HP:0001839)1.76864032
72Short hallux (HP:0010109)1.75929055
73Oligodontia (HP:0000677)1.75762710
74Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75489432
75Esophageal atresia (HP:0002032)1.75321149
76Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75187297
77Short 1st metacarpal (HP:0010034)1.75187297
78Abnormality of the labia majora (HP:0012881)1.74334485
79Curly hair (HP:0002212)1.74308969
80Hypotrichosis (HP:0001006)1.74135420
81Aortic dissection (HP:0002647)1.73980058
82Dilatation of the ascending aorta (HP:0005111)1.73890694
83Partial duplication of the phalanx of hand (HP:0009999)1.73087293
84Aplasia involving bones of the extremities (HP:0009825)1.72328655
85Aplasia involving bones of the upper limbs (HP:0009823)1.72328655
86Aplasia of the phalanges of the hand (HP:0009802)1.72328655
87Preaxial foot polydactyly (HP:0001841)1.71929196
88Arnold-Chiari malformation (HP:0002308)1.71298751
89Germ cell neoplasia (HP:0100728)1.70591903
90Renal duplication (HP:0000075)1.70361243
91Broad toe (HP:0001837)1.69987987
92Thick nail (HP:0001805)1.69052431
93Hip contracture (HP:0003273)1.68787998
94Microglossia (HP:0000171)1.67754726
95Partial duplication of thumb phalanx (HP:0009944)1.67491105
96Hallux valgus (HP:0001822)1.67291542
97Facial hemangioma (HP:0000329)1.67108633
98Abnormal vertebral ossification (HP:0100569)1.66943800
99Hematochezia (HP:0002573)1.66809848
100Abnormality of the diencephalon (HP:0010662)1.66438509
101Long clavicles (HP:0000890)1.66427622
102Lower limb amyotrophy (HP:0007210)1.66191808
103Abnormality of the 2nd finger (HP:0004100)1.65105239
104Tracheomalacia (HP:0002779)1.64075113
105Broad face (HP:0000283)1.63976990
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.63215259
107Limited hip movement (HP:0008800)1.63161194
108Missing ribs (HP:0000921)1.63106707
109Hydroureter (HP:0000072)1.63033482
110Aplasia cutis congenita (HP:0001057)1.62112528
111Spinal cord lesions (HP:0100561)1.60797621
112Syringomyelia (HP:0003396)1.60797621
113Broad phalanx (HP:0006009)1.60203023
114Spinal rigidity (HP:0003306)1.59264778
115Ankle contracture (HP:0006466)1.58524677
116Skull defect (HP:0001362)1.58325815
117Absent eyelashes (HP:0000561)1.58272024
118Camptodactyly of toe (HP:0001836)1.58229517
119Soft skin (HP:0000977)1.57728109
120Aplasia/Hypoplasia of the clavicles (HP:0006710)1.57591784
121Scapular winging (HP:0003691)1.57186944
122Broad hallux (HP:0010055)1.56460877
123Broad finger (HP:0001500)1.56242892
124Abnormality of oral frenula (HP:0000190)1.55678220
125Bowing of the arm (HP:0006488)1.55622322
126Bowed forearm bones (HP:0003956)1.55622322
127Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.55112725
128Thin bony cortex (HP:0002753)1.54918622
129Laryngomalacia (HP:0001601)1.54881846
130Increased connective tissue (HP:0009025)1.54275530
131Renal hypoplasia (HP:0000089)1.54088822
132Short nail (HP:0001799)1.53883783
133Aplasia/Hypoplasia of the hallux (HP:0008362)1.53782472
134Renal dysplasia (HP:0000110)1.53361008
135Short metatarsal (HP:0010743)1.52810453
136Genu recurvatum (HP:0002816)1.52792350
137Broad long bones (HP:0005622)1.50472387
138Congenital malformation of the right heart (HP:0011723)1.50376229
139Double outlet right ventricle (HP:0001719)1.50376229
140Abnormality of the 1st metacarpal (HP:0010009)1.50349928
141Tarsal synostosis (HP:0008368)1.50045476
142Broad phalanges of the hand (HP:0009768)1.49992340
143Shawl scrotum (HP:0000049)1.49712288
144Hyperacusis (HP:0010780)1.48859883
145Megalencephaly (HP:0001355)1.46878217
146Elfin facies (HP:0004428)1.46210158
14711 pairs of ribs (HP:0000878)1.45952798
148Plantar hyperkeratosis (HP:0007556)1.45335329
149Abnormality of the antihelix (HP:0009738)1.44511518
150Wormian bones (HP:0002645)1.43186309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.08574558
2LATS23.37862748
3* EPHB22.79028659
4MARK12.74883248
5ERBB32.71747084
6CASK2.55198651
7TIE12.52268708
8PNCK2.46896970
9DDR22.29460907
10FER2.13643843
11EPHA41.95303822
12EPHA21.93283730
13MAP3K101.90885944
14RIPK11.90493609
15FRK1.89885474
16DMPK1.86642231
17TNIK1.82081596
18PDGFRA1.81858576
19PRKD31.68081502
20TTN1.67279645
21FGFR21.65183489
22MST1R1.58651762
23STK38L1.48256771
24MAP3K91.48058825
25TAOK11.46267830
26KSR11.45245106
27PTK21.44447325
28MAPK151.42495745
29PLK21.42410301
30CDK121.39720305
31TGFBR11.38573641
32BCR1.37170038
33CAMK1G1.34895176
34MAP3K21.29224140
35PTK61.28121723
36MKNK21.23046211
37NUAK11.21692902
38FGFR11.18989384
39STK31.18656798
40WEE11.16121582
41MOS1.13725081
42PAK31.11840651
43PTK2B1.09477169
44ROCK11.08855102
45AKT31.08001006
46MINK11.03744580
47BRD41.03535161
48SIK11.00840320
49INSRR1.00426683
50ARAF0.94586772
51NTRK30.94373533
52MET0.93142014
53TRIB30.90392178
54LMTK20.89987203
55PDGFRB0.86646546
56PAK20.86404212
57MAP3K30.86021832
58DAPK20.85175666
59EPHA30.84695414
60PAK40.83926915
61BRSK20.82204450
62CAMK1D0.80725322
63BMX0.78421434
64KDR0.76680788
65MAP3K40.76441191
66EEF2K0.74896641
67ERBB20.74417327
68STK390.73752885
69PAK60.73730051
70TYRO30.72674625
71LIMK10.72098785
72RET0.71903601
73PKN20.71491781
74STK380.70650483
75TGFBR20.69824259
76MAP2K10.69028733
77YES10.68336460
78FGFR30.68074920
79KSR20.66603965
80TESK10.65994265
81BMPR1B0.65292500
82NEK90.65266193
83MKNK10.65030159
84MTOR0.64497413
85TRIM280.63572224
86TRPM70.62357012
87PRKCE0.61888650
88CDK60.60998082
89LRRK20.59275200
90TAF10.58540940
91STK110.57327985
92MAPK130.53940618
93CSNK1A1L0.53234097
94PLK30.53221144
95NTRK20.52888617
96NTRK10.52877078
97PRKD10.52040368
98SGK4940.51790848
99SGK2230.51790848
100RPS6KA20.51659127
101ERBB40.50604532
102TSSK60.49736633
103RPS6KA40.49398036
104CDK50.47621008
105CDK30.45968804
106CAMKK10.45879052
107CDK150.45671979
108ICK0.45407238
109MST40.45365329
110PRKCH0.45254756
111SGK20.44700760
112ROCK20.44551218
113CSNK1G10.44247132
114STK240.43691098
115PIK3CA0.43358169
116DYRK20.42917966
117SGK30.41275578
118ILK0.40959095
119CSNK1G20.40932564
120CDK140.39548062
121DYRK1A0.39310206
122SGK10.38960196
123CDK11A0.38502744
124MARK20.38218358
125GSK3A0.36849800
126CDK180.36762604
127SRC0.36142376
128CDK80.35972980
129NEK20.35321042
130PRKCZ0.33877936
131PRKD20.29327546
132SMG10.28401331
133PHKG10.27324311
134PHKG20.27324311

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.44292483
2Hippo signaling pathway_Homo sapiens_hsa043902.40073910
3Adherens junction_Homo sapiens_hsa045202.31145962
4* Axon guidance_Homo sapiens_hsa043602.15421560
5ECM-receptor interaction_Homo sapiens_hsa045122.12213481
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.93319692
7Focal adhesion_Homo sapiens_hsa045101.84568934
8TGF-beta signaling pathway_Homo sapiens_hsa043501.82454667
9Hedgehog signaling pathway_Homo sapiens_hsa043401.79436618
10Proteoglycans in cancer_Homo sapiens_hsa052051.79078447
11Melanogenesis_Homo sapiens_hsa049161.76945318
12Tight junction_Homo sapiens_hsa045301.69755476
13Wnt signaling pathway_Homo sapiens_hsa043101.64085484
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.62181888
15Dilated cardiomyopathy_Homo sapiens_hsa054141.59193224
16Endometrial cancer_Homo sapiens_hsa052131.54485861
17MicroRNAs in cancer_Homo sapiens_hsa052061.49006465
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.47771556
19Small cell lung cancer_Homo sapiens_hsa052221.43254301
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36948126
21Rap1 signaling pathway_Homo sapiens_hsa040151.36474461
22Bladder cancer_Homo sapiens_hsa052191.34009631
23Gap junction_Homo sapiens_hsa045401.32323705
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32037151
25Glioma_Homo sapiens_hsa052141.30911802
26Dorso-ventral axis formation_Homo sapiens_hsa043201.27254627
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26962921
28Amoebiasis_Homo sapiens_hsa051461.24303445
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23128946
30Long-term potentiation_Homo sapiens_hsa047201.21739889
31Colorectal cancer_Homo sapiens_hsa052101.20677715
32Prion diseases_Homo sapiens_hsa050201.20344658
33Thyroid cancer_Homo sapiens_hsa052161.20036156
34GnRH signaling pathway_Homo sapiens_hsa049121.16662825
35Renin secretion_Homo sapiens_hsa049241.15911983
36Estrogen signaling pathway_Homo sapiens_hsa049151.14615272
37Renal cell carcinoma_Homo sapiens_hsa052111.13513496
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13483099
39Oxytocin signaling pathway_Homo sapiens_hsa049211.13042496
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12399342
41Circadian entrainment_Homo sapiens_hsa047131.11570165
42Pathways in cancer_Homo sapiens_hsa052001.11489060
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09850594
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09557905
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07472318
46ErbB signaling pathway_Homo sapiens_hsa040121.06806981
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05262727
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04938559
49Prostate cancer_Homo sapiens_hsa052151.04804647
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.04727518
51Gastric acid secretion_Homo sapiens_hsa049711.03691211
52Dopaminergic synapse_Homo sapiens_hsa047281.03241810
53Melanoma_Homo sapiens_hsa052181.02894605
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01518791
55Amphetamine addiction_Homo sapiens_hsa050311.00918270
56Viral myocarditis_Homo sapiens_hsa054160.98999949
57Chronic myeloid leukemia_Homo sapiens_hsa052200.98191542
58Cholinergic synapse_Homo sapiens_hsa047250.97092180
59VEGF signaling pathway_Homo sapiens_hsa043700.96798676
60Protein digestion and absorption_Homo sapiens_hsa049740.96392299
61Steroid biosynthesis_Homo sapiens_hsa001000.95945768
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91992800
63Salivary secretion_Homo sapiens_hsa049700.91788019
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.91208554
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91079503
66Cocaine addiction_Homo sapiens_hsa050300.91047803
67Ras signaling pathway_Homo sapiens_hsa040140.90923116
68Pancreatic cancer_Homo sapiens_hsa052120.90647129
69Olfactory transduction_Homo sapiens_hsa047400.90563923
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89890036
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89735150
72Notch signaling pathway_Homo sapiens_hsa043300.85927337
73cAMP signaling pathway_Homo sapiens_hsa040240.85387988
74Long-term depression_Homo sapiens_hsa047300.83950733
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.81708467
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.80587215
77Glutamatergic synapse_Homo sapiens_hsa047240.80478349
78Cell cycle_Homo sapiens_hsa041100.80266210
79MAPK signaling pathway_Homo sapiens_hsa040100.79742175
80HTLV-I infection_Homo sapiens_hsa051660.79057267
81mTOR signaling pathway_Homo sapiens_hsa041500.78341127
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76122802
83Platelet activation_Homo sapiens_hsa046110.75748095
84Oocyte meiosis_Homo sapiens_hsa041140.74740112
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73683834
86FoxO signaling pathway_Homo sapiens_hsa040680.72362666
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72010351
88Nicotine addiction_Homo sapiens_hsa050330.71744498
89Non-small cell lung cancer_Homo sapiens_hsa052230.71507019
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69969120
91Serotonergic synapse_Homo sapiens_hsa047260.68613139
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66266226
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65865453
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65567600
95Morphine addiction_Homo sapiens_hsa050320.64531625
96Salmonella infection_Homo sapiens_hsa051320.63785253
97Lysine degradation_Homo sapiens_hsa003100.63016691
98Endocytosis_Homo sapiens_hsa041440.62931915
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62116876
100Insulin signaling pathway_Homo sapiens_hsa049100.62090343
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.61486909
102Choline metabolism in cancer_Homo sapiens_hsa052310.61275029
103Toxoplasmosis_Homo sapiens_hsa051450.60746904
104p53 signaling pathway_Homo sapiens_hsa041150.60138550
105GABAergic synapse_Homo sapiens_hsa047270.59660345
106Thyroid hormone synthesis_Homo sapiens_hsa049180.59210512
107Prolactin signaling pathway_Homo sapiens_hsa049170.59185820
108Mineral absorption_Homo sapiens_hsa049780.58792976
109TNF signaling pathway_Homo sapiens_hsa046680.58596731
110AMPK signaling pathway_Homo sapiens_hsa041520.58465001
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.58286938
112HIF-1 signaling pathway_Homo sapiens_hsa040660.53724830
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48741810
114Circadian rhythm_Homo sapiens_hsa047100.45404370
115Bile secretion_Homo sapiens_hsa049760.44612149
116Glucagon signaling pathway_Homo sapiens_hsa049220.43785244
117mRNA surveillance pathway_Homo sapiens_hsa030150.43168696
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42962399

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