EFNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)5.04781908
2glomerular visceral epithelial cell development (GO:0072015)4.98414442
3planar cell polarity pathway involved in neural tube closure (GO:0090179)4.90399413
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.64844816
5glomerular epithelial cell development (GO:0072310)4.50650805
6cell-substrate junction assembly (GO:0007044)4.24863069
7lateral sprouting from an epithelium (GO:0060601)4.22911697
8chondrocyte proliferation (GO:0035988)4.11774393
9desmosome organization (GO:0002934)3.93965756
10glomerulus development (GO:0032835)3.87426271
11epithelial cell-cell adhesion (GO:0090136)3.86405710
12dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.78846105
13keratinocyte proliferation (GO:0043616)3.73009734
14hemidesmosome assembly (GO:0031581)3.69718860
15axon extension involved in axon guidance (GO:0048846)3.67513155
16neuron projection extension involved in neuron projection guidance (GO:1902284)3.67513155
17protein heterotrimerization (GO:0070208)3.55566233
18atrioventricular valve morphogenesis (GO:0003181)3.50564399
19bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44001018
20establishment of skin barrier (GO:0061436)3.39835140
21positive regulation of chondrocyte differentiation (GO:0032332)3.37197618
22regulation of transforming growth factor beta2 production (GO:0032909)3.31782769
23lymph vessel development (GO:0001945)3.27971074
24cell migration involved in sprouting angiogenesis (GO:0002042)3.27916846
25negative regulation of keratinocyte proliferation (GO:0010839)3.27806433
26paraxial mesoderm development (GO:0048339)3.25980350
27positive regulation of cartilage development (GO:0061036)3.25743125
28hippo signaling (GO:0035329)3.24033660
29lens morphogenesis in camera-type eye (GO:0002089)3.22949093
30vascular endothelial growth factor signaling pathway (GO:0038084)3.19343811
31regulation of water loss via skin (GO:0033561)3.17591555
32G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.16924368
33convergent extension (GO:0060026)3.16135332
34embryonic foregut morphogenesis (GO:0048617)3.14344606
35endocardial cushion morphogenesis (GO:0003203)3.13360369
36Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.13168634
37negative regulation of cell fate specification (GO:0009996)3.11042307
38negative regulation of catenin import into nucleus (GO:0035414)3.09683090
39polarized epithelial cell differentiation (GO:0030859)3.09511839
40establishment of planar polarity (GO:0001736)3.09465977
41establishment of tissue polarity (GO:0007164)3.09465977
42coronary vasculature morphogenesis (GO:0060977)3.08519952
43mesenchyme morphogenesis (GO:0072132)3.07215968
44regulation of establishment of planar polarity (GO:0090175)3.05319348
45somite development (GO:0061053)3.04579418
46regulation of keratinocyte proliferation (GO:0010837)3.04565783
47gap junction assembly (GO:0016264)3.04344265
48respiratory tube development (GO:0030323)3.03899968
49renal filtration (GO:0097205)3.01208069
50axon extension (GO:0048675)3.00044355
51regulation of hair follicle development (GO:0051797)2.99261697
52basement membrane organization (GO:0071711)2.97673044
53skin morphogenesis (GO:0043589)2.97491513
54establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.97435080
55cell migration involved in heart development (GO:0060973)2.93600276
56midgut development (GO:0007494)2.92373075
57non-canonical Wnt signaling pathway (GO:0035567)2.91298144
58negative regulation of chondrocyte differentiation (GO:0032331)2.89100513
59cell surface receptor signaling pathway involved in heart development (GO:0061311)2.88196323
60blood vessel endothelial cell migration (GO:0043534)2.88167159
61negative regulation of axon extension involved in axon guidance (GO:0048843)2.86129801
62regulation of cardioblast differentiation (GO:0051890)2.84951544
63positive regulation of BMP signaling pathway (GO:0030513)2.84585553
64cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.83793432
65calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.83185849
66negative regulation of axon guidance (GO:1902668)2.82937304
67intermediate filament organization (GO:0045109)2.81812406
68negative regulation of epidermis development (GO:0045683)2.80724481
69collagen fibril organization (GO:0030199)2.79256318
70regulation of chondrocyte differentiation (GO:0032330)2.77662449
71positive regulation of epithelial to mesenchymal transition (GO:0010718)2.77507421
72glial cell migration (GO:0008347)2.77384267
73semaphorin-plexin signaling pathway (GO:0071526)2.76104803
74bone trabecula formation (GO:0060346)2.74900282
75embryonic retina morphogenesis in camera-type eye (GO:0060059)2.74829867
76positive regulation of mesenchymal cell proliferation (GO:0002053)2.74573202
77epidermis development (GO:0008544)2.72641880
78regulation of cartilage development (GO:0061035)2.70696984
79mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.69409891
80regulation of p38MAPK cascade (GO:1900744)2.69290013
81renal system development (GO:0072001)2.68791251
82regulation of heart morphogenesis (GO:2000826)2.68522550
83dorsal/ventral axis specification (GO:0009950)2.68234326
84proximal/distal pattern formation (GO:0009954)2.67971769
85outer ear morphogenesis (GO:0042473)2.67252129
86branching involved in salivary gland morphogenesis (GO:0060445)2.65331233
87regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.65303140
88endothelial cell morphogenesis (GO:0001886)2.64555980
89epithelial cell differentiation involved in prostate gland development (GO:0060742)2.64490086
90negative regulation of cartilage development (GO:0061037)2.63749393
91endothelial cell chemotaxis (GO:0035767)2.63577308
92patterning of blood vessels (GO:0001569)2.63484202
93pattern specification involved in kidney development (GO:0061004)2.63116174
94cochlea morphogenesis (GO:0090103)2.63009602
95regulation of hippo signaling (GO:0035330)2.62626951
96neuron projection extension (GO:1990138)2.62422633
97regulation of axon guidance (GO:1902667)2.61938948
98cardiac muscle cell proliferation (GO:0060038)2.61513912
99regulation of axon extension involved in axon guidance (GO:0048841)2.61054665
100lung vasculature development (GO:0060426)2.60913222
101protein retention in ER lumen (GO:0006621)2.60905029
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60418219
103* ephrin receptor signaling pathway (GO:0048013)2.60395727
104collecting duct development (GO:0072044)2.60209188
105wound healing, spreading of epidermal cells (GO:0035313)2.59680153
106mesodermal cell differentiation (GO:0048333)2.58546864
107limb bud formation (GO:0060174)2.57794278
108regulation of endothelial cell chemotaxis (GO:2001026)2.56946707
109glomerular filtration (GO:0003094)2.54590134
110retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54401070
111surfactant homeostasis (GO:0043129)2.53797449
112skin development (GO:0043588)2.53535381
113regulation of mesenchymal cell proliferation (GO:0010464)2.52850595
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52839974
115post-anal tail morphogenesis (GO:0036342)2.52295027
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.52270676
117ectoderm development (GO:0007398)2.52229008
118cell adhesion mediated by integrin (GO:0033627)2.51210014
119lymphangiogenesis (GO:0001946)2.50696771
120embryonic viscerocranium morphogenesis (GO:0048703)2.50531157
121cell proliferation involved in metanephros development (GO:0072203)2.49928548
122endocardial cushion development (GO:0003197)2.49616353
123keratinization (GO:0031424)2.49148083
124anatomical structure regression (GO:0060033)2.48920659
125negative regulation of cell fate commitment (GO:0010454)2.48777713
126regulation of cell fate specification (GO:0042659)2.47946054
127lung-associated mesenchyme development (GO:0060484)2.47844795
128artery development (GO:0060840)2.47477020
129ganglion development (GO:0061548)2.47342302
130eye morphogenesis (GO:0048592)2.47297560
131positive regulation of p38MAPK cascade (GO:1900745)2.47031650
132endodermal cell differentiation (GO:0035987)2.46219610
133L-serine transport (GO:0015825)2.45383704
134camera-type eye morphogenesis (GO:0048593)2.45119107
135cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.44615746
136adherens junction organization (GO:0034332)2.44347604
137keratinocyte differentiation (GO:0030216)2.42634084
138cell junction assembly (GO:0034329)2.40371667
139extracellular matrix disassembly (GO:0022617)2.37797227
140collagen metabolic process (GO:0032963)2.35604061
141collagen catabolic process (GO:0030574)2.35276855
142asymmetric protein localization (GO:0008105)2.35164305
143multicellular organismal water homeostasis (GO:0050891)2.35040544
144neural tube development (GO:0021915)2.34399861
145negative regulation of stem cell proliferation (GO:2000647)2.32435443
146multicellular organismal macromolecule metabolic process (GO:0044259)2.32195427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.24157165
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.80833461
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.49495494
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.05284150
5CLOCK_20551151_ChIP-Seq_293T_Human2.74517944
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59044236
7EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.37423884
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33186030
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32248373
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.12439402
11ZFP281_18757296_ChIP-ChIP_E14_Mouse1.97747306
12ESR1_21235772_ChIP-Seq_MCF-7_Human1.95389712
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95214910
14TP53_20018659_ChIP-ChIP_R1E_Mouse1.93210498
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.91699151
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.90445015
17CDX2_20551321_ChIP-Seq_CACO-2_Human1.85826912
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84547075
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82224073
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80382296
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79092510
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77809712
23LXR_22292898_ChIP-Seq_THP-1_Human1.77257504
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.73219029
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.73082015
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71078712
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71078712
28RACK7_27058665_Chip-Seq_MCF-7_Human1.69711987
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69467643
30ZNF263_19887448_ChIP-Seq_K562_Human1.63355182
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63013700
32* KDM2B_26808549_Chip-Seq_K562_Human1.59976386
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56739847
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.53685016
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53674838
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53452576
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53153864
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52097135
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51989387
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50574305
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48532588
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47546650
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.46763622
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46279874
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45757017
46EZH2_22144423_ChIP-Seq_EOC_Human1.43794868
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43318232
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42684234
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39692902
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39662850
51TP53_22127205_ChIP-Seq_IMR90_Human1.37412601
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36735791
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36668161
54KDM2B_26808549_Chip-Seq_DND41_Human1.36663079
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36136185
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33471236
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.32165776
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31945976
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30000518
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.29988456
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.29447359
62SOX2_20726797_ChIP-Seq_SW620_Human1.28945614
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.28841860
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28208123
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27655587
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.26937073
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24675080
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24512119
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.22727596
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22301706
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21522833
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20203474
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20086459
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.19794587
75CREB1_26743006_Chip-Seq_LNCaP_Human1.18872377
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18426732
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.18032201
78* RING1B_27294783_Chip-Seq_NPCs_Mouse1.17848396
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.17792445
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16766853
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16766853
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16277432
83ATF3_27146783_Chip-Seq_COLON_Human1.14660733
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.14617034
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.12957359
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12950293
87SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12510695
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.11438595
89* TP63_22573176_ChIP-Seq_HFKS_Human1.11177351
90CTCF_27219007_Chip-Seq_Bcells_Human1.11163463
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10422556
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.10291307
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.10291307
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09426843
95* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08704675
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08582993
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07976016
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07767422
99LXR_22158963_ChIP-Seq_LIVER_Mouse1.06947019
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06758878
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06017211
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05745739
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03799343
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03026233
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01732462
106UBF1/2_26484160_Chip-Seq_HMECs_Human1.01628611
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01446270
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00637079
109KLF5_25053715_ChIP-Seq_YYC3_Human0.99626621
110* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99007907
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98863388
112ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98698354
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.98524251
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98264710
115* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97486132
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.95784194
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94749945
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94141000
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92318053
120TET1_21490601_ChIP-Seq_MESCs_Mouse0.92037162
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91868980
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89853599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.02066770
2MP0003705_abnormal_hypodermis_morpholog3.76842981
3MP0004272_abnormal_basement_membrane3.48918742
4MP0003283_abnormal_digestive_organ3.45959250
5MP0000537_abnormal_urethra_morphology3.38311368
6MP0009053_abnormal_anal_canal3.36241385
7MP0010030_abnormal_orbit_morphology3.31543814
8MP0005275_abnormal_skin_tensile3.08600886
9MP0008438_abnormal_cutaneous_collagen2.89992142
10MP0010368_abnormal_lymphatic_system2.37093171
11MP0002234_abnormal_pharynx_morphology2.26818044
12MP0003315_abnormal_perineum_morphology2.10039894
13MP0003566_abnormal_cell_adhesion2.05986572
14MP0000462_abnormal_digestive_system2.05026169
15MP0005503_abnormal_tendon_morphology2.02822186
16MP0006054_spinal_hemorrhage2.00270960
17MP0009379_abnormal_foot_pigmentation1.99871536
18MP0006292_abnormal_olfactory_placode1.97708282
19MP0005499_abnormal_olfactory_system1.97416000
20MP0005394_taste/olfaction_phenotype1.97416000
21MP0004858_abnormal_nervous_system1.94263034
22MP0005623_abnormal_meninges_morphology1.90083735
23MP0003942_abnormal_urinary_system1.87213735
24MP0000566_synostosis1.83299120
25MP0000534_abnormal_ureter_morphology1.81879320
26* MP0003385_abnormal_body_wall1.77489093
27MP0002249_abnormal_larynx_morphology1.76571053
28MP0009384_cardiac_valve_regurgitation1.72188013
29MP0010678_abnormal_skin_adnexa1.67448314
30MP0000762_abnormal_tongue_morphology1.65414671
31MP0000579_abnormal_nail_morphology1.63307619
32MP0005409_darkened_coat_color1.62471924
33MP0002932_abnormal_joint_morphology1.62062560
34MP0001879_abnormal_lymphatic_vessel1.57098950
35MP0009250_abnormal_appendicular_skeleto1.54492581
36MP0003115_abnormal_respiratory_system1.52476287
37MP0002796_impaired_skin_barrier1.52398178
38MP0001958_emphysema1.45290996
39MP0005187_abnormal_penis_morphology1.44773792
40MP0003279_aneurysm1.42530135
41MP0002233_abnormal_nose_morphology1.41069636
42* MP0002098_abnormal_vibrissa_morphology1.40730823
43MP0003941_abnormal_skin_development1.38530399
44MP0000383_abnormal_hair_follicle1.36503837
45MP0005248_abnormal_Harderian_gland1.36411500
46* MP0002282_abnormal_trachea_morphology1.36396529
47MP0000428_abnormal_craniofacial_morphol1.35793538
48* MP0005508_abnormal_skeleton_morphology1.34553780
49* MP0003755_abnormal_palate_morphology1.31928007
50MP0002896_abnormal_bone_mineralization1.30666075
51* MP0000049_abnormal_middle_ear1.29552317
52MP0003122_maternal_imprinting1.29341684
53MP0003937_abnormal_limbs/digits/tail_de1.28282114
54* MP0000778_abnormal_nervous_system1.27203966
55MP0003119_abnormal_digestive_system1.27150827
56MP0004185_abnormal_adipocyte_glucose1.24934237
57MP0001299_abnormal_eye_distance/1.22741788
58MP0000467_abnormal_esophagus_morphology1.22658408
59MP0002060_abnormal_skin_morphology1.22337789
60MP0005076_abnormal_cell_differentiation1.21314097
61MP0001849_ear_inflammation1.18363742
62* MP0003935_abnormal_craniofacial_develop1.17983693
63MP0004264_abnormal_extraembryonic_tissu1.16551833
64* MP0000163_abnormal_cartilage_morphology1.16084800
65MP0002653_abnormal_ependyma_morphology1.13641224
66MP0010771_integument_phenotype1.13001117
67MP0000767_abnormal_smooth_muscle1.12127858
68MP0000678_abnormal_parathyroid_gland1.10778749
69MP0000647_abnormal_sebaceous_gland1.10264795
70MP0005367_renal/urinary_system_phenotyp1.09855414
71MP0000516_abnormal_urinary_system1.09855414
72* MP0002116_abnormal_craniofacial_bone1.07060414
73MP0000377_abnormal_hair_follicle1.06308157
74MP0002697_abnormal_eye_size1.01909059
75MP0003091_abnormal_cell_migration0.99927066
76MP0004084_abnormal_cardiac_muscle0.99420730
77MP0005670_abnormal_white_adipose0.98253806
78MP0001293_anophthalmia0.98162834
79MP0005501_abnormal_skin_physiology0.98143202
80MP0002111_abnormal_tail_morphology0.97860895
81MP0000733_abnormal_muscle_development0.95853508
82MP0005167_abnormal_blood-brain_barrier0.93959348
83MP0005023_abnormal_wound_healing0.92747436
84MP0002092_abnormal_eye_morphology0.91916840
85MP0003938_abnormal_ear_development0.91128502
86MP0000432_abnormal_head_morphology0.90218276
87* MP0002115_abnormal_skeleton_extremities0.90051490
88MP0005257_abnormal_intraocular_pressure0.89831589
89MP0003123_paternal_imprinting0.89269366
90MP0010352_gastrointestinal_tract_polyps0.87476551
91MP0002089_abnormal_postnatal_growth/wei0.86282212
92MP0005197_abnormal_uvea_morphology0.86155603
93MP0006138_congestive_heart_failure0.84108473
94MP0002177_abnormal_outer_ear0.82628385
95MP0005360_urolithiasis0.81753838
96MP0004782_abnormal_surfactant_physiolog0.80931292
97MP0001216_abnormal_epidermal_layer0.80547366
98MP0005666_abnormal_adipose_tissue0.80107587
99MP0000538_abnormal_urinary_bladder0.80068402
100MP0002925_abnormal_cardiovascular_devel0.79715645
101MP0000026_abnormal_inner_ear0.78782215
102* MP0002109_abnormal_limb_morphology0.78593646
103MP0000751_myopathy0.78572558
104MP0000013_abnormal_adipose_tissue0.77656825
105MP0002295_abnormal_pulmonary_circulatio0.77541497
106* MP0001286_abnormal_eye_development0.77281760
107MP0002938_white_spotting0.77112204
108MP0008789_abnormal_olfactory_epithelium0.75933538
109MP0009931_abnormal_skin_appearance0.75647130
110MP0003252_abnormal_bile_duct0.75530546
111* MP0002113_abnormal_skeleton_development0.75312865
112MP0003878_abnormal_ear_physiology0.75306164
113MP0005377_hearing/vestibular/ear_phenot0.75306164
114MP0001270_distended_abdomen0.75299119
115MP0004134_abnormal_chest_morphology0.74157370
116MP0003453_abnormal_keratinocyte_physiol0.73538268
117MP0003861_abnormal_nervous_system0.73519072
118MP0001614_abnormal_blood_vessel0.72782210
119MP0008961_abnormal_basal_metabolism0.72392711
120MP0002128_abnormal_blood_circulation0.71884979
121MP0000477_abnormal_intestine_morphology0.70568631
122MP0005375_adipose_tissue_phenotype0.70240428
123MP0001666_abnormal_nutrient_absorption0.68625323
124* MP0001340_abnormal_eyelid_morphology0.68607851
125MP0003329_amyloid_beta_deposits0.66039688
126MP0005193_abnormal_anterior_eye0.65700785
127MP0002108_abnormal_muscle_morphology0.65599588
128* MP0002114_abnormal_axial_skeleton0.62290024

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)4.60952909
2Plantar hyperkeratosis (HP:0007556)4.37410850
3Abnormality of nail color (HP:0100643)4.27504880
4Onycholysis (HP:0001806)4.17084263
5Protrusio acetabuli (HP:0003179)4.08877927
6Shallow orbits (HP:0000586)3.99019264
7Thick nail (HP:0001805)3.91494784
8Alopecia of scalp (HP:0002293)3.88394488
9Premature rupture of membranes (HP:0001788)3.70045327
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.64498241
11Short 4th metacarpal (HP:0010044)3.64498241
12Atrophic scars (HP:0001075)3.47622609
13Abnormality of the distal phalanx of the thumb (HP:0009617)3.38451795
14Right ventricular cardiomyopathy (HP:0011663)3.35586394
15Broad metatarsal (HP:0001783)3.14759988
16Mesangial abnormality (HP:0001966)3.11423103
17Palmoplantar hyperkeratosis (HP:0000972)3.05170693
18Abnormality of the 4th metacarpal (HP:0010012)3.01693932
19Lymphangioma (HP:0100764)2.99536194
20Palmar hyperkeratosis (HP:0010765)2.90019025
21Cerebral aneurysm (HP:0004944)2.89672333
22Visceral angiomatosis (HP:0100761)2.87314414
23Ankle contracture (HP:0006466)2.87113165
24Nail dystrophy (HP:0008404)2.83146516
25Flat acetabular roof (HP:0003180)2.78541876
26Aortic dissection (HP:0002647)2.70909749
27Pili torti (HP:0003777)2.66477445
28Fragile skin (HP:0001030)2.65874224
29Abnormality of the 1st metacarpal (HP:0010009)2.64863072
30Bladder diverticulum (HP:0000015)2.63337157
31Short phalanx of the thumb (HP:0009660)2.62673950
32* Pterygium (HP:0001059)2.62639675
33Hemangiomatosis (HP:0007461)2.58645799
34Focal segmental glomerulosclerosis (HP:0000097)2.53733812
35Cervical subluxation (HP:0003308)2.53317653
36Cupped ribs (HP:0000887)2.49895649
37Renal duplication (HP:0000075)2.45345215
38Bronchomalacia (HP:0002780)2.44445174
39Selective tooth agenesis (HP:0001592)2.44156353
40Hip contracture (HP:0003273)2.41560788
41Aortic aneurysm (HP:0004942)2.39392191
42Increased connective tissue (HP:0009025)2.35480861
43Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.33434395
44Abnormal ossification of hand bones (HP:0005921)2.30381386
45Abnormality of the middle phalanges of the toes (HP:0010183)2.28370217
46Short hallux (HP:0010109)2.28338295
47Symphalangism affecting the phalanges of the hand (HP:0009773)2.27754560
48Arterial tortuosity (HP:0005116)2.27185634
49Milia (HP:0001056)2.26055709
50Abnormality of the 2nd finger (HP:0004100)2.24045975
51Hypoplasia of dental enamel (HP:0006297)2.21659598
52Wide anterior fontanel (HP:0000260)2.20406915
53Mitral valve prolapse (HP:0001634)2.17626033
54Hepatoblastoma (HP:0002884)2.17135357
55Short nail (HP:0001799)2.16807596
56Abnormal vertebral ossification (HP:0100569)2.16726083
57Aplasia cutis congenita (HP:0001057)2.15739086
58Vascular tortuosity (HP:0004948)2.14095873
59Mildly elevated creatine phosphokinase (HP:0008180)2.13989335
60Advanced eruption of teeth (HP:0006288)2.13474706
61Posterior subcapsular cataract (HP:0007787)2.13253327
62Abnormality of carpal bone ossification (HP:0006257)2.11428509
63Germ cell neoplasia (HP:0100728)2.10605372
64Thin bony cortex (HP:0002753)2.10552071
65Abnormal blistering of the skin (HP:0008066)2.09393647
66Abnormal hair laboratory examination (HP:0003328)2.09017342
67Deviation of the hallux (HP:0010051)2.08899298
68Neonatal death (HP:0003811)2.08441916
69Absent eyelashes (HP:0000561)2.07276286
70Rectal prolapse (HP:0002035)2.04658263
71Esophageal atresia (HP:0002032)2.03411981
72Breech presentation (HP:0001623)2.03270188
73* Ridged nail (HP:0001807)2.03237843
74Type 1 muscle fiber predominance (HP:0003803)2.02519470
75Aplasia/Hypoplasia of the hallux (HP:0008362)2.02461074
76Blue sclerae (HP:0000592)2.02374850
77Sparse scalp hair (HP:0002209)2.02113557
78Aplasia involving bones of the upper limbs (HP:0009823)2.01508298
79Aplasia of the phalanges of the hand (HP:0009802)2.01508298
80Aplasia involving bones of the extremities (HP:0009825)2.01508298
81Abnormal hand bone ossification (HP:0010660)2.01362354
82Anonychia (HP:0001798)2.00173898
83Laryngomalacia (HP:0001601)2.00001661
84Hallux valgus (HP:0001822)1.99566868
85Soft skin (HP:0000977)1.99395707
86Abnormality of the calcaneus (HP:0008364)1.99323862
87Hyperextensible skin (HP:0000974)1.98847607
88Peritonitis (HP:0002586)1.97286030
89Abnormality of the phalanges of the hallux (HP:0010057)1.96963673
90Vertebral hypoplasia (HP:0008417)1.96531694
91Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.96531694
92Camptodactyly of toe (HP:0001836)1.95139768
93Vertebral clefting (HP:0008428)1.93010959
94Follicular hyperkeratosis (HP:0007502)1.92934069
95* Woolly hair (HP:0002224)1.92843959
96Glomerulosclerosis (HP:0000096)1.92109182
97Genu recurvatum (HP:0002816)1.91398690
98Partial duplication of thumb phalanx (HP:0009944)1.90955962
99Aneurysm (HP:0002617)1.90778056
100Spinal cord compression (HP:0002176)1.89411753
101Spinal rigidity (HP:0003306)1.88448889
102Absent phalangeal crease (HP:0006109)1.88140937
103Limited hip movement (HP:0008800)1.83931142
104Ankyloglossia (HP:0010296)1.83817350
105Turricephaly (HP:0000262)1.83806486
106Cutaneous finger syndactyly (HP:0010554)1.83213052
10711 pairs of ribs (HP:0000878)1.82731984
108Abnormal cartilage morphology (HP:0002763)1.82156165
109Split foot (HP:0001839)1.81535971
110Hyperacusis (HP:0010780)1.81507388
111Short middle phalanx of finger (HP:0005819)1.80580684
112* Fragile nails (HP:0001808)1.80529629
113Large earlobe (HP:0009748)1.80510756
114Abnormality of the aortic arch (HP:0012303)1.79780378
115Partial duplication of the phalanx of hand (HP:0009999)1.79628867
116Ventricular tachycardia (HP:0004756)1.79492908
117Concave nail (HP:0001598)1.78949861
118Renal dysplasia (HP:0000110)1.78790778
119Back pain (HP:0003418)1.77820254
120Wide cranial sutures (HP:0010537)1.75875213
121Vitreoretinal degeneration (HP:0000655)1.75237825
122Cutaneous syndactyly (HP:0012725)1.74755871
123Acanthosis nigricans (HP:0000956)1.73678638
124Tibial bowing (HP:0002982)1.73409186
125Renovascular hypertension (HP:0100817)1.71917775
126Increased variability in muscle fiber diameter (HP:0003557)1.71882600
127Dilatation of the ascending aorta (HP:0005111)1.71516236
128Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.71137743
129Trigonocephaly (HP:0000243)1.70592287
130Thin ribs (HP:0000883)1.70075519
131Ulnar bowing (HP:0003031)1.68964561
132Metaphyseal cupping (HP:0003021)1.68893435
133Hypodontia (HP:0000668)1.67381880
134Natal tooth (HP:0000695)1.66881968
135Overgrowth (HP:0001548)1.66805224
136Abnormality of dentin (HP:0010299)1.66678122
137Subcapsular cataract (HP:0000523)1.66631794
138Hypotrichosis (HP:0001006)1.66100779
139Broad face (HP:0000283)1.65699460
140Hypoalbuminemia (HP:0003073)1.65603884
141Abnormal albumin level (HP:0012116)1.65603884
142Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65471017
143Neoplasm of the heart (HP:0100544)1.65451133
144Knee flexion contracture (HP:0006380)1.65196473
145Deep venous thrombosis (HP:0002625)1.64832109
146Flattened epiphyses (HP:0003071)1.64610738
147Mitral regurgitation (HP:0001653)1.64418933
148Hypoplastic labia majora (HP:0000059)1.63748267
149Abdominal distention (HP:0003270)1.63348725
150Broad thumb (HP:0011304)1.61566279
151Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.61235743
152Oligodontia (HP:0000677)1.60517551
153Abnormality of the proximal phalanges of the hand (HP:0009834)1.57685127
154* Coronal craniosynostosis (HP:0004440)1.55204433
155Distal lower limb amyotrophy (HP:0008944)1.53409245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.69958523
2* EPHB24.21832939
3TRIB34.14541779
4MAP3K103.24135493
5RIPK12.60715654
6WNK32.49692720
7LMTK22.46626587
8PTK62.46345565
9PDGFRA2.46226009
10TIE12.33418011
11LATS12.30274258
12PKN22.16127211
13ERN12.12763005
14TTN2.07738152
15FER2.07367722
16DDR22.00644201
17PAK41.97263991
18ICK1.86617046
19SIK11.78427352
20LATS21.73982950
21TGFBR21.64475403
22MYLK1.57664796
23EEF2K1.55919507
24ARAF1.52995497
25ILK1.45949848
26ERBB21.41377287
27MAP2K21.38218482
28EPHA41.38149353
29KDR1.31489956
30EPHA31.30684496
31TGFBR11.30671384
32PTK21.28606633
33FGFR21.28223325
34SMG11.21253268
35CDK191.19158061
36PAK21.18670048
37MST1R1.16863249
38TAOK11.16131172
39PIM21.13224150
40LRRK21.13175839
41DMPK1.11380525
42FGFR41.10344989
43MTOR1.06683670
44FGFR11.06030169
45ROCK10.99692518
46PRKD30.95633257
47MET0.95122462
48MAP3K60.92908590
49CASK0.92720344
50EPHA20.92249263
51IRAK30.91224458
52STK240.88113945
53RPS6KL10.87953861
54RPS6KC10.87953861
55TYRO30.86438461
56DYRK1B0.82735686
57PIK3CA0.81731195
58MARK10.81430812
59FLT30.81167783
60TESK10.80194474
61CDK90.79354777
62KSR10.78058724
63RPS6KA40.77643465
64MAP3K90.76501456
65TLK10.76239095
66BRAF0.74548861
67MAP2K10.74111055
68DYRK30.72746899
69WNK40.69943417
70CDK60.69612224
71GSK3A0.69481210
72RPS6KA60.68473510
73PAK30.67642085
74PRKD10.66717537
75PRKG20.66132412
76PDGFRB0.65041918
77PHKG20.62843293
78PHKG10.62843293
79MOS0.61671723
80MAPK150.59734296
81PRKD20.58806732
82BMX0.57661007
83IRAK20.56982920
84MARK20.56733284
85MAP3K70.55966707
86CDK120.49953607
87CDK80.49841040
88CDC42BPA0.47658447
89AKT20.47651708
90MAPK70.47564784
91RPS6KB20.47311644
92STK390.47206962
93EPHB10.46010841
94PRKCI0.45048766
95PTK2B0.44484799
96CDK70.43759851
97LIMK10.40174249
98DYRK20.39386527
99KSR20.39384952
100RET0.38949545
101* SRC0.38938245
102MAP3K20.38541108
103NEK90.38303594
104ERBB30.38037925
105FGFR30.37673542
106SGK2230.37389774
107SGK4940.37389774
108BCR0.37367981
109DAPK30.35996145
110RPS6KA10.35976426
111STK30.35959829
112ROCK20.35843406
113FRK0.35663126
114MELK0.34478473
115CAMK1G0.34366416
116STK38L0.33023841
117NTRK20.33015989
118MAPK90.32110576
119MAP3K80.32109066
120MAPK110.31481475
121CAMK1D0.29391512
122MAP3K30.29094930
123ABL20.27578594
124PRPF4B0.27304269
125NTRK10.27274319
126RPS6KA20.26853417
127PRKCZ0.26477514
128MAPKAPK30.26435287
129CDK11A0.25195644
130STK100.25067585
131CDK150.25007909
132CDK30.22901222
133CDK180.22890440

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.21330507
2ECM-receptor interaction_Homo sapiens_hsa045123.04134431
3Hedgehog signaling pathway_Homo sapiens_hsa043402.69367553
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.45136944
5Hippo signaling pathway_Homo sapiens_hsa043902.27913299
6Protein digestion and absorption_Homo sapiens_hsa049742.22582051
7Focal adhesion_Homo sapiens_hsa045102.16947335
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01970229
9Adherens junction_Homo sapiens_hsa045201.98679449
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.86551436
11Proteoglycans in cancer_Homo sapiens_hsa052051.86340271
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.84234039
13Renin-angiotensin system_Homo sapiens_hsa046141.80805805
14Bladder cancer_Homo sapiens_hsa052191.80439797
15Small cell lung cancer_Homo sapiens_hsa052221.76879275
16Notch signaling pathway_Homo sapiens_hsa043301.75990692
17* Axon guidance_Homo sapiens_hsa043601.73856921
18Steroid biosynthesis_Homo sapiens_hsa001001.71269357
19Fat digestion and absorption_Homo sapiens_hsa049751.66582593
20Tight junction_Homo sapiens_hsa045301.63010211
21Sulfur metabolism_Homo sapiens_hsa009201.60487922
22TGF-beta signaling pathway_Homo sapiens_hsa043501.55502516
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54271194
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51649747
25Amoebiasis_Homo sapiens_hsa051461.50573281
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47854617
27Fatty acid degradation_Homo sapiens_hsa000711.42278934
28Chronic myeloid leukemia_Homo sapiens_hsa052201.37664075
29PPAR signaling pathway_Homo sapiens_hsa033201.34931481
30Endometrial cancer_Homo sapiens_hsa052131.31136974
31Lysine degradation_Homo sapiens_hsa003101.30779842
32Dilated cardiomyopathy_Homo sapiens_hsa054141.30378449
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27410564
34MicroRNAs in cancer_Homo sapiens_hsa052061.25279007
35Mineral absorption_Homo sapiens_hsa049781.23458229
36Melanogenesis_Homo sapiens_hsa049161.22217027
37Bile secretion_Homo sapiens_hsa049761.21274023
38Wnt signaling pathway_Homo sapiens_hsa043101.20753372
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19939567
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18370303
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.12046189
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10130262
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09708884
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07892341
45Sulfur relay system_Homo sapiens_hsa041221.07348521
46Pathways in cancer_Homo sapiens_hsa052001.05730100
47Galactose metabolism_Homo sapiens_hsa000521.05311216
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04324886
49Fatty acid metabolism_Homo sapiens_hsa012121.02696658
50Fructose and mannose metabolism_Homo sapiens_hsa000511.01832214
51Glycerolipid metabolism_Homo sapiens_hsa005611.01103629
52Prion diseases_Homo sapiens_hsa050201.00597088
53PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97870061
54Tryptophan metabolism_Homo sapiens_hsa003800.89689791
55Rap1 signaling pathway_Homo sapiens_hsa040150.87366567
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85829799
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85640430
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85557499
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.83234963
60Insulin resistance_Homo sapiens_hsa049310.81622827
61Dorso-ventral axis formation_Homo sapiens_hsa043200.81560741
62Pancreatic cancer_Homo sapiens_hsa052120.80926902
63Biosynthesis of amino acids_Homo sapiens_hsa012300.80531663
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.79959728
65Viral myocarditis_Homo sapiens_hsa054160.79473818
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79217809
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78999146
68VEGF signaling pathway_Homo sapiens_hsa043700.77439986
69Phenylalanine metabolism_Homo sapiens_hsa003600.77257463
70Thyroid cancer_Homo sapiens_hsa052160.75830249
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74307872
72Butanoate metabolism_Homo sapiens_hsa006500.73786855
73AMPK signaling pathway_Homo sapiens_hsa041520.73711605
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72535543
75Ovarian steroidogenesis_Homo sapiens_hsa049130.72449131
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71170734
77Gap junction_Homo sapiens_hsa045400.70611621
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69476735
79Colorectal cancer_Homo sapiens_hsa052100.68988411
80Prostate cancer_Homo sapiens_hsa052150.68011782
81Insulin signaling pathway_Homo sapiens_hsa049100.67179705
82Renal cell carcinoma_Homo sapiens_hsa052110.66343029
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65244458
84Arginine biosynthesis_Homo sapiens_hsa002200.64739715
85Melanoma_Homo sapiens_hsa052180.64007888
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63466230
87Complement and coagulation cascades_Homo sapiens_hsa046100.63070035
88Glioma_Homo sapiens_hsa052140.62856371
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.62849160
90Arginine and proline metabolism_Homo sapiens_hsa003300.62063450
91Fatty acid biosynthesis_Homo sapiens_hsa000610.61852075
92Estrogen signaling pathway_Homo sapiens_hsa049150.61574094
93HTLV-I infection_Homo sapiens_hsa051660.60599025
94Fatty acid elongation_Homo sapiens_hsa000620.56605557
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55531024
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54422259
97Starch and sucrose metabolism_Homo sapiens_hsa005000.53544808
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53033761
99Toxoplasmosis_Homo sapiens_hsa051450.52944470
100Non-small cell lung cancer_Homo sapiens_hsa052230.51687403
101mTOR signaling pathway_Homo sapiens_hsa041500.51655229
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.51571472
103Thyroid hormone synthesis_Homo sapiens_hsa049180.51304548
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48841426
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48198454
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47422343
107Propanoate metabolism_Homo sapiens_hsa006400.47398511
108Chemical carcinogenesis_Homo sapiens_hsa052040.47296722
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.46809658
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45622613
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.45538325
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44900935
113Carbon metabolism_Homo sapiens_hsa012000.44642627
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44508837
115Caffeine metabolism_Homo sapiens_hsa002320.44268965
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43782732
117Platelet activation_Homo sapiens_hsa046110.43674345
118Vitamin digestion and absorption_Homo sapiens_hsa049770.41557968
119Glucagon signaling pathway_Homo sapiens_hsa049220.41513101
120Pentose phosphate pathway_Homo sapiens_hsa000300.41022235
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40705305
122Ether lipid metabolism_Homo sapiens_hsa005650.39692344
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39195439
124Histidine metabolism_Homo sapiens_hsa003400.38721430
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38505675
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38374540
127Acute myeloid leukemia_Homo sapiens_hsa052210.37800192
128p53 signaling pathway_Homo sapiens_hsa041150.37732306
129ErbB signaling pathway_Homo sapiens_hsa040120.37730996
130Retinol metabolism_Homo sapiens_hsa008300.36390287
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35891131
132Endocytosis_Homo sapiens_hsa041440.35226529

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